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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PTPN12-RSBN1L

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PTPN12-RSBN1L
FusionPDB ID: 70201
FusionGDB2.0 ID: 70201
HgeneTgene
Gene symbol

PTPN12

RSBN1L

Gene ID

5782

222194

Gene nameprotein tyrosine phosphatase non-receptor type 12round spermatid basic protein 1 like
SynonymsPTP-PEST|PTPG1-
Cytomap

7q11.23

7q11.23

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein phosphatase non-receptor type 12protein-tyrosine phosphatase G1lysine-specific demethylase RSBN1Lround spermatid basic protein 1-like protein
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000248594, ENST00000415482, 
ENST00000435495, 		ENST00000445288, 
ENST00000334955, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score22 X 21 X 16=73926 X 9 X 9=486
# samples 4417
** MAII scorelog2(44/7392*10)=-4.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/486*10)=-1.51542156746808
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PTPN12 [Title/Abstract] AND RSBN1L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PTPN12(77166962)-RSBN1L(77365727), # samples:6
RSBN1L(77398120)-PTPN12(77214860), # samples:3
Anticipated loss of major functional domain due to fusion event.PTPN12-RSBN1L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPN12-RSBN1L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPN12-RSBN1L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPN12-RSBN1L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPN12-RSBN1L seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PTPN12-RSBN1L seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
PTPN12-RSBN1L seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
RSBN1L-PTPN12 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RSBN1L-PTPN12 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
RSBN1L-PTPN12 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPN12

GO:0006470

protein dephosphorylation

27134172

HgenePTPN12

GO:0035335

peptidyl-tyrosine dephosphorylation

27134172


check buttonFusion gene breakpoints across PTPN12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RSBN1L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AC-A2BK-01APTPN12chr7

77166962

+RSBN1Lchr7

77365727

+
ChimerDB4COADTCGA-AM-5821-01APTPN12chr7

77247882

+RSBN1Lchr7

77365727

+
ChimerDB4COADTCGA-AM-5821PTPN12chr7

77247882

+RSBN1Lchr7

77365726

+
ChimerDB4ESCATCGA-2H-A9GHPTPN12chr7

77256992

+RSBN1Lchr7

77365726

+
ChimerDB4ESCATCGA-V5-A7RBPTPN12chr7

77166962

+RSBN1Lchr7

77365727

+
ChimerDB4LUADTCGA-91-6836-01APTPN12chr7

77166962

+RSBN1Lchr7

77365727

+
ChimerDB4LUADTCGA-91-6836PTPN12chr7

77166962

+RSBN1Lchr7

77365726

+
ChimerDB4MESOTCGA-TS-A7PB-01APTPN12chr7

77166962

+RSBN1Lchr7

77365727

+
ChimerDB4OVTCGA-04-1530-01APTPN12chr7

77256992

+RSBN1Lchr7

77365727

+
ChimerDB4OVTCGA-25-1625-01APTPN12chr7

77256992

+RSBN1Lchr7

77378741

+
ChimerDB4OVTCGA-25-1625PTPN12chr7

77256992

+RSBN1Lchr7

77378740

+
ChimerDB4OVTCGA-30-1718-01APTPN12chr7

77166962

+RSBN1Lchr7

77365727

+
ChimerDB4OVTCGA-61-1733PTPN12chr7

77212967

+RSBN1Lchr7

77365726

+
ChimerDB4STADTCGA-BR-8382PTPN12chr7

77200503

+RSBN1Lchr7

77365726

+
ChimerDB4STADTCGA-BR-8382PTPN12chr7

77230123

+RSBN1Lchr7

77365726

+
ChimerDB4STADTCGA-HU-A4H2PTPN12chr7

77230123

+RSBN1Lchr7

77365726

+
ChimerDB4STADTCGA-VQ-A94O-01APTPN12chr7

77166962

+RSBN1Lchr7

77365727

+
ChimerDB4STADTCGA-VQ-A94OPTPN12chr7

77166962

+RSBN1Lchr7

77365726

+
ChimerDB4UCSTCGA-NA-A4QWPTPN12chr7

77166962

+RSBN1Lchr7

77378740

+
ChimerDB4UCSTCGA-NA-A4QWPTPN12chr7

77166962

+RSBN1Lchr7

77378741

+
ChimerDB4UCSTCGA-NA-A4QWPTPN12chr7

77166962

+RSBN1Lchr7

77394812

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000248594PTPN12chr777256992+ENST00000334955RSBN1Lchr777365726+80772268242221406
ENST00000415482PTPN12chr777256992+ENST00000334955RSBN1Lchr777365726+777819698439231279
ENST00000435495PTPN12chr777256992+ENST00000334955RSBN1Lchr777365726+764818395037931247
ENST00000248594PTPN12chr777256992+ENST00000334955RSBN1Lchr777378740+79602268241051367
ENST00000415482PTPN12chr777256992+ENST00000334955RSBN1Lchr777378740+766119698438061240
ENST00000435495PTPN12chr777256992+ENST00000334955RSBN1Lchr777378740+753118395036761208
ENST00000248594PTPN12chr777200503+ENST00000334955RSBN1Lchr777365726+628948022434810
ENST00000248594PTPN12chr777256992+ENST00000334955RSBN1Lchr777378741+79602268241051367
ENST00000415482PTPN12chr777256992+ENST00000334955RSBN1Lchr777378741+766119698438061240
ENST00000435495PTPN12chr777256992+ENST00000334955RSBN1Lchr777378741+753118395036761208
ENST00000248594PTPN12chr777256992+ENST00000334955RSBN1Lchr777365727+80772268242221406
ENST00000415482PTPN12chr777256992+ENST00000334955RSBN1Lchr777365727+777819698439231279
ENST00000435495PTPN12chr777256992+ENST00000334955RSBN1Lchr777365727+764818395037931247
ENST00000248594PTPN12chr777166962+ENST00000334955RSBN1Lchr777394812+542237121567521
ENST00000248594PTPN12chr777166962+ENST00000445288RSBN1Lchr777394812+208237121567521

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000248594ENST00000334955PTPN12chr777256992+RSBN1Lchr777365726+0.0001346630.9998653
ENST00000415482ENST00000334955PTPN12chr777256992+RSBN1Lchr777365726+0.0001461750.99985385
ENST00000435495ENST00000334955PTPN12chr777256992+RSBN1Lchr777365726+0.0001295030.99987054
ENST00000248594ENST00000334955PTPN12chr777256992+RSBN1Lchr777378740+8.94E-050.9999106
ENST00000415482ENST00000334955PTPN12chr777256992+RSBN1Lchr777378740+9.81E-050.9999019
ENST00000435495ENST00000334955PTPN12chr777256992+RSBN1Lchr777378740+8.73E-050.99991274
ENST00000248594ENST00000334955PTPN12chr777200503+RSBN1Lchr777365726+8.55E-050.9999145
ENST00000248594ENST00000334955PTPN12chr777256992+RSBN1Lchr777378741+8.94E-050.9999106
ENST00000415482ENST00000334955PTPN12chr777256992+RSBN1Lchr777378741+9.81E-050.9999019
ENST00000435495ENST00000334955PTPN12chr777256992+RSBN1Lchr777378741+8.73E-050.99991274
ENST00000248594ENST00000334955PTPN12chr777256992+RSBN1Lchr777365727+0.0001346630.9998653
ENST00000415482ENST00000334955PTPN12chr777256992+RSBN1Lchr777365727+0.0001461750.99985385
ENST00000435495ENST00000334955PTPN12chr777256992+RSBN1Lchr777365727+0.0001295030.99987054
ENST00000248594ENST00000334955PTPN12chr777166962+RSBN1Lchr777394812+0.0001463110.9998536
ENST00000248594ENST00000445288PTPN12chr777166962+RSBN1Lchr777394812+0.0003627130.99963725

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>70201_70201_1_PTPN12-RSBN1L_PTPN12_chr7_77166962_ENST00000248594_RSBN1L_chr7_77394812_ENST00000334955_length(amino acids)=521AA_BP=0
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMVKRTYSHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSL
KLQSRKDSDDGPIMWVRPGEQMIPVADMPKSPFKRKRTTNEIKNLQYLPRTSEPREMLFEDRTRAHADHIGQGFERQTTAAVGVLKAVHC
GEWPDQPRITKDVICFHAEDFLEVVQRMQLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCSLA
WHIRLKLYHSEEDTSQNTATHETGTSSDSTSSVLGPHTDNMICAVSKASLDSVFSDKLHSKYELQQIKHEPIASVRIKEEPVNVNIPEKT

--------------------------------------------------------------

>70201_70201_2_PTPN12-RSBN1L_PTPN12_chr7_77166962_ENST00000248594_RSBN1L_chr7_77394812_ENST00000445288_length(amino acids)=521AA_BP=0
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMVKRTYSHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSL
KLQSRKDSDDGPIMWVRPGEQMIPVADMPKSPFKRKRTTNEIKNLQYLPRTSEPREMLFEDRTRAHADHIGQGFERQTTAAVGVLKAVHC
GEWPDQPRITKDVICFHAEDFLEVVQRMQLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCSLA
WHIRLKLYHSEEDTSQNTATHETGTSSDSTSSVLGPHTDNMICAVSKASLDSVFSDKLHSKYELQQIKHEPIASVRIKEEPVNVNIPEKT

--------------------------------------------------------------

>70201_70201_3_PTPN12-RSBN1L_PTPN12_chr7_77200503_ENST00000248594_RSBN1L_chr7_77365726_ENST00000334955_length(amino acids)=810AA_BP=0
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPYKIKDKIKERDKEKEREKKKH
KVMNEIKKENGEVKILLKSGKEKPKTNIEDLQIKKVKKKKKKKHKENEKRKRPKMYSKSIQTICSGLLTDVEDQAAKGILNDNIKDYVGK
NLDTKNYDSKIPENSEFPFVSLKEPRVQNNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSENENSA
AFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTYSHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDM
LEESPFLKCTLPWGTLSSLKLQSRKDSDDGPIMWVRPGEQMIPVADMPKSPFKRKRTTNEIKNLQYLPRTSEPREMLFEDRTRAHADHIG
QGFERQTTAAVGVLKAVHCGEWPDQPRITKDVICFHAEDFLEVVQRMQLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYF
IPRNVVHQFKTVSAVCSLAWHIRLKLYHSEEDTSQNTATHETGTSSDSTSSVLGPHTDNMICAVSKASLDSVFSDKLHSKYELQQIKHEP
IASVRIKEEPVNVNIPEKTTALNNMDGKNVKAKLDHVQFAEFKIDMDSKFENSNKDLKEELCPGNLSLVDTRQHSSAHSNQDKKDDDILC

--------------------------------------------------------------

>70201_70201_4_PTPN12-RSBN1L_PTPN12_chr7_77256992_ENST00000248594_RSBN1L_chr7_77365726_ENST00000334955_length(amino acids)=1406AA_BP=0
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYIN
ANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLL
EFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMR
TQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPH
PVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGPKSF
DGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHG
PENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNISTASAT
VSAATSTESISTRKVLPMSIARHNIAGTTHSGAEKDKIKDKIKERDKEKEREKKKHKVMNEIKKENGEVKILLKSGKEKPKTNIEDLQIK
KVKKKKKKKHKENEKRKRPKMYSKSIQTICSGLLTDVEDQAAKGILNDNIKDYVGKNLDTKNYDSKIPENSEFPFVSLKEPRVQNNLKRL
DTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSENENSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKME
ILGKKDIETTTMSNFHAQVKRTYSHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDSDDGPIMW
VRPGEQMIPVADMPKSPFKRKRTTNEIKNLQYLPRTSEPREMLFEDRTRAHADHIGQGFERQTTAAVGVLKAVHCGEWPDQPRITKDVIC
FHAEDFLEVVQRMQLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCSLAWHIRLKLYHSEEDTS
QNTATHETGTSSDSTSSVLGPHTDNMICAVSKASLDSVFSDKLHSKYELQQIKHEPIASVRIKEEPVNVNIPEKTTALNNMDGKNVKAKL

--------------------------------------------------------------

>70201_70201_5_PTPN12-RSBN1L_PTPN12_chr7_77256992_ENST00000248594_RSBN1L_chr7_77365727_ENST00000334955_length(amino acids)=1406AA_BP=0
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYIN
ANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLL
EFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMR
TQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPH
PVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGPKSF
DGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHG
PENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNISTASAT
VSAATSTESISTRKVLPMSIARHNIAGTTHSGAEKDKIKDKIKERDKEKEREKKKHKVMNEIKKENGEVKILLKSGKEKPKTNIEDLQIK
KVKKKKKKKHKENEKRKRPKMYSKSIQTICSGLLTDVEDQAAKGILNDNIKDYVGKNLDTKNYDSKIPENSEFPFVSLKEPRVQNNLKRL
DTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSENENSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKME
ILGKKDIETTTMSNFHAQVKRTYSHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDSDDGPIMW
VRPGEQMIPVADMPKSPFKRKRTTNEIKNLQYLPRTSEPREMLFEDRTRAHADHIGQGFERQTTAAVGVLKAVHCGEWPDQPRITKDVIC
FHAEDFLEVVQRMQLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCSLAWHIRLKLYHSEEDTS
QNTATHETGTSSDSTSSVLGPHTDNMICAVSKASLDSVFSDKLHSKYELQQIKHEPIASVRIKEEPVNVNIPEKTTALNNMDGKNVKAKL

--------------------------------------------------------------

>70201_70201_6_PTPN12-RSBN1L_PTPN12_chr7_77256992_ENST00000248594_RSBN1L_chr7_77378740_ENST00000334955_length(amino acids)=1367AA_BP=0
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYIN
ANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLL
EFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMR
TQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPH
PVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGPKSF
DGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHG
PENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNISTASAT
VSAATSTESISTRKVLPMSIARHNIAGTTHSGAEKGGKEKPKTNIEDLQIKKVKKKKKKKHKENEKRKRPKMYSKSIQTICSGLLTDVED
QAAKGILNDNIKDYVGKNLDTKNYDSKIPENSEFPFVSLKEPRVQNNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMER
FAEEFVGLVFSENENSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTYSHGTYRAGPMRQISLV
GAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDSDDGPIMWVRPGEQMIPVADMPKSPFKRKRTTNEIKNLQYLPRTSEP
REMLFEDRTRAHADHIGQGFERQTTAAVGVLKAVHCGEWPDQPRITKDVICFHAEDFLEVVQRMQLDLHEPPLSQCVQWVDDAKLNQLRR
EGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCSLAWHIRLKLYHSEEDTSQNTATHETGTSSDSTSSVLGPHTDNMICAVSKASLDSVF
SDKLHSKYELQQIKHEPIASVRIKEEPVNVNIPEKTTALNNMDGKNVKAKLDHVQFAEFKIDMDSKFENSNKDLKEELCPGNLSLVDTRQ

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>70201_70201_7_PTPN12-RSBN1L_PTPN12_chr7_77256992_ENST00000248594_RSBN1L_chr7_77378741_ENST00000334955_length(amino acids)=1367AA_BP=0
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYIN
ANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLL
EFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMR
TQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPH
PVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGPKSF
DGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHG
PENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNISTASAT
VSAATSTESISTRKVLPMSIARHNIAGTTHSGAEKGGKEKPKTNIEDLQIKKVKKKKKKKHKENEKRKRPKMYSKSIQTICSGLLTDVED
QAAKGILNDNIKDYVGKNLDTKNYDSKIPENSEFPFVSLKEPRVQNNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMER
FAEEFVGLVFSENENSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTYSHGTYRAGPMRQISLV
GAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDSDDGPIMWVRPGEQMIPVADMPKSPFKRKRTTNEIKNLQYLPRTSEP
REMLFEDRTRAHADHIGQGFERQTTAAVGVLKAVHCGEWPDQPRITKDVICFHAEDFLEVVQRMQLDLHEPPLSQCVQWVDDAKLNQLRR
EGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCSLAWHIRLKLYHSEEDTSQNTATHETGTSSDSTSSVLGPHTDNMICAVSKASLDSVF
SDKLHSKYELQQIKHEPIASVRIKEEPVNVNIPEKTTALNNMDGKNVKAKLDHVQFAEFKIDMDSKFENSNKDLKEELCPGNLSLVDTRQ

--------------------------------------------------------------

>70201_70201_8_PTPN12-RSBN1L_PTPN12_chr7_77256992_ENST00000415482_RSBN1L_chr7_77365726_ENST00000334955_length(amino acids)=1279AA_BP=1
MSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVV
IIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMR
KYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQ
KIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVS
SEQHSADLNRNYSKSTELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNV
GDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVE
TPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNISTASATVSAATSTESISTRKVLPMSIARHNIAGTTHSGAEKDK
IKDKIKERDKEKEREKKKHKVMNEIKKENGEVKILLKSGKEKPKTNIEDLQIKKVKKKKKKKHKENEKRKRPKMYSKSIQTICSGLLTDV
EDQAAKGILNDNIKDYVGKNLDTKNYDSKIPENSEFPFVSLKEPRVQNNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEM
ERFAEEFVGLVFSENENSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTYSHGTYRAGPMRQIS
LVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDSDDGPIMWVRPGEQMIPVADMPKSPFKRKRTTNEIKNLQYLPRTS
EPREMLFEDRTRAHADHIGQGFERQTTAAVGVLKAVHCGEWPDQPRITKDVICFHAEDFLEVVQRMQLDLHEPPLSQCVQWVDDAKLNQL
RREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCSLAWHIRLKLYHSEEDTSQNTATHETGTSSDSTSSVLGPHTDNMICAVSKASLDS
VFSDKLHSKYELQQIKHEPIASVRIKEEPVNVNIPEKTTALNNMDGKNVKAKLDHVQFAEFKIDMDSKFENSNKDLKEELCPGNLSLVDT

--------------------------------------------------------------

>70201_70201_9_PTPN12-RSBN1L_PTPN12_chr7_77256992_ENST00000415482_RSBN1L_chr7_77365727_ENST00000334955_length(amino acids)=1279AA_BP=1
MSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVV
IIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMR
KYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQ
KIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVS
SEQHSADLNRNYSKSTELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNV
GDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVE
TPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNISTASATVSAATSTESISTRKVLPMSIARHNIAGTTHSGAEKDK
IKDKIKERDKEKEREKKKHKVMNEIKKENGEVKILLKSGKEKPKTNIEDLQIKKVKKKKKKKHKENEKRKRPKMYSKSIQTICSGLLTDV
EDQAAKGILNDNIKDYVGKNLDTKNYDSKIPENSEFPFVSLKEPRVQNNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEM
ERFAEEFVGLVFSENENSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTYSHGTYRAGPMRQIS
LVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDSDDGPIMWVRPGEQMIPVADMPKSPFKRKRTTNEIKNLQYLPRTS
EPREMLFEDRTRAHADHIGQGFERQTTAAVGVLKAVHCGEWPDQPRITKDVICFHAEDFLEVVQRMQLDLHEPPLSQCVQWVDDAKLNQL
RREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCSLAWHIRLKLYHSEEDTSQNTATHETGTSSDSTSSVLGPHTDNMICAVSKASLDS
VFSDKLHSKYELQQIKHEPIASVRIKEEPVNVNIPEKTTALNNMDGKNVKAKLDHVQFAEFKIDMDSKFENSNKDLKEELCPGNLSLVDT

--------------------------------------------------------------

>70201_70201_10_PTPN12-RSBN1L_PTPN12_chr7_77256992_ENST00000415482_RSBN1L_chr7_77378740_ENST00000334955_length(amino acids)=1240AA_BP=1
MSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVV
IIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMR
KYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQ
KIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVS
SEQHSADLNRNYSKSTELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNV
GDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVE
TPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNISTASATVSAATSTESISTRKVLPMSIARHNIAGTTHSGAEKGG
KEKPKTNIEDLQIKKVKKKKKKKHKENEKRKRPKMYSKSIQTICSGLLTDVEDQAAKGILNDNIKDYVGKNLDTKNYDSKIPENSEFPFV
SLKEPRVQNNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSENENSAAFYVMGIVHGAATYLPDFLD
YFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTYSHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLK
LQSRKDSDDGPIMWVRPGEQMIPVADMPKSPFKRKRTTNEIKNLQYLPRTSEPREMLFEDRTRAHADHIGQGFERQTTAAVGVLKAVHCG
EWPDQPRITKDVICFHAEDFLEVVQRMQLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCSLAW
HIRLKLYHSEEDTSQNTATHETGTSSDSTSSVLGPHTDNMICAVSKASLDSVFSDKLHSKYELQQIKHEPIASVRIKEEPVNVNIPEKTT

--------------------------------------------------------------

>70201_70201_11_PTPN12-RSBN1L_PTPN12_chr7_77256992_ENST00000415482_RSBN1L_chr7_77378741_ENST00000334955_length(amino acids)=1240AA_BP=1
MSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVV
IIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMR
KYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQ
KIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVS
SEQHSADLNRNYSKSTELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNV
GDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVE
TPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNISTASATVSAATSTESISTRKVLPMSIARHNIAGTTHSGAEKGG
KEKPKTNIEDLQIKKVKKKKKKKHKENEKRKRPKMYSKSIQTICSGLLTDVEDQAAKGILNDNIKDYVGKNLDTKNYDSKIPENSEFPFV
SLKEPRVQNNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSENENSAAFYVMGIVHGAATYLPDFLD
YFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTYSHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLK
LQSRKDSDDGPIMWVRPGEQMIPVADMPKSPFKRKRTTNEIKNLQYLPRTSEPREMLFEDRTRAHADHIGQGFERQTTAAVGVLKAVHCG
EWPDQPRITKDVICFHAEDFLEVVQRMQLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCSLAW
HIRLKLYHSEEDTSQNTATHETGTSSDSTSSVLGPHTDNMICAVSKASLDSVFSDKLHSKYELQQIKHEPIASVRIKEEPVNVNIPEKTT

--------------------------------------------------------------

>70201_70201_12_PTPN12-RSBN1L_PTPN12_chr7_77256992_ENST00000435495_RSBN1L_chr7_77365726_ENST00000334955_length(amino acids)=1247AA_BP=1
MSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKIIVMACREFEMGRKKCERYWPLYGEDPITFAP
FKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWN
LLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPR
TRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNESTIEQIDKK
LERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDT
PPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSD
ERNSDGAVTQNKTNISTASATVSAATSTESISTRKVLPMSIARHNIAGTTHSGAEKDKIKDKIKERDKEKEREKKKHKVMNEIKKENGEV
KILLKSGKEKPKTNIEDLQIKKVKKKKKKKHKENEKRKRPKMYSKSIQTICSGLLTDVEDQAAKGILNDNIKDYVGKNLDTKNYDSKIPE
NSEFPFVSLKEPRVQNNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSENENSAAFYVMGIVHGAAT
YLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTYSHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPW
GTLSSLKLQSRKDSDDGPIMWVRPGEQMIPVADMPKSPFKRKRTTNEIKNLQYLPRTSEPREMLFEDRTRAHADHIGQGFERQTTAAVGV
LKAVHCGEWPDQPRITKDVICFHAEDFLEVVQRMQLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVS
AVCSLAWHIRLKLYHSEEDTSQNTATHETGTSSDSTSSVLGPHTDNMICAVSKASLDSVFSDKLHSKYELQQIKHEPIASVRIKEEPVNV

--------------------------------------------------------------

>70201_70201_13_PTPN12-RSBN1L_PTPN12_chr7_77256992_ENST00000435495_RSBN1L_chr7_77365727_ENST00000334955_length(amino acids)=1247AA_BP=1
MSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKIIVMACREFEMGRKKCERYWPLYGEDPITFAP
FKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWN
LLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPR
TRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNESTIEQIDKK
LERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDT
PPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSD
ERNSDGAVTQNKTNISTASATVSAATSTESISTRKVLPMSIARHNIAGTTHSGAEKDKIKDKIKERDKEKEREKKKHKVMNEIKKENGEV
KILLKSGKEKPKTNIEDLQIKKVKKKKKKKHKENEKRKRPKMYSKSIQTICSGLLTDVEDQAAKGILNDNIKDYVGKNLDTKNYDSKIPE
NSEFPFVSLKEPRVQNNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSENENSAAFYVMGIVHGAAT
YLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTYSHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPW
GTLSSLKLQSRKDSDDGPIMWVRPGEQMIPVADMPKSPFKRKRTTNEIKNLQYLPRTSEPREMLFEDRTRAHADHIGQGFERQTTAAVGV
LKAVHCGEWPDQPRITKDVICFHAEDFLEVVQRMQLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVS
AVCSLAWHIRLKLYHSEEDTSQNTATHETGTSSDSTSSVLGPHTDNMICAVSKASLDSVFSDKLHSKYELQQIKHEPIASVRIKEEPVNV

--------------------------------------------------------------

>70201_70201_14_PTPN12-RSBN1L_PTPN12_chr7_77256992_ENST00000435495_RSBN1L_chr7_77378740_ENST00000334955_length(amino acids)=1208AA_BP=1
MSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKIIVMACREFEMGRKKCERYWPLYGEDPITFAP
FKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWN
LLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPR
TRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNESTIEQIDKK
LERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDT
PPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSD
ERNSDGAVTQNKTNISTASATVSAATSTESISTRKVLPMSIARHNIAGTTHSGAEKGGKEKPKTNIEDLQIKKVKKKKKKKHKENEKRKR
PKMYSKSIQTICSGLLTDVEDQAAKGILNDNIKDYVGKNLDTKNYDSKIPENSEFPFVSLKEPRVQNNLKRLDTLEFKQLIHIEHQPNGG
ASVIHAYSNELSHLSPMEMERFAEEFVGLVFSENENSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQ
VKRTYSHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDSDDGPIMWVRPGEQMIPVADMPKSPF
KRKRTTNEIKNLQYLPRTSEPREMLFEDRTRAHADHIGQGFERQTTAAVGVLKAVHCGEWPDQPRITKDVICFHAEDFLEVVQRMQLDLH
EPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCSLAWHIRLKLYHSEEDTSQNTATHETGTSSDSTSSV
LGPHTDNMICAVSKASLDSVFSDKLHSKYELQQIKHEPIASVRIKEEPVNVNIPEKTTALNNMDGKNVKAKLDHVQFAEFKIDMDSKFEN

--------------------------------------------------------------

>70201_70201_15_PTPN12-RSBN1L_PTPN12_chr7_77256992_ENST00000435495_RSBN1L_chr7_77378741_ENST00000334955_length(amino acids)=1208AA_BP=1
MSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKIIVMACREFEMGRKKCERYWPLYGEDPITFAP
FKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWN
LLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPR
TRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNESTIEQIDKK
LERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDT
PPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSD
ERNSDGAVTQNKTNISTASATVSAATSTESISTRKVLPMSIARHNIAGTTHSGAEKGGKEKPKTNIEDLQIKKVKKKKKKKHKENEKRKR
PKMYSKSIQTICSGLLTDVEDQAAKGILNDNIKDYVGKNLDTKNYDSKIPENSEFPFVSLKEPRVQNNLKRLDTLEFKQLIHIEHQPNGG
ASVIHAYSNELSHLSPMEMERFAEEFVGLVFSENENSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQ
VKRTYSHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDSDDGPIMWVRPGEQMIPVADMPKSPF
KRKRTTNEIKNLQYLPRTSEPREMLFEDRTRAHADHIGQGFERQTTAAVGVLKAVHCGEWPDQPRITKDVICFHAEDFLEVVQRMQLDLH
EPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCSLAWHIRLKLYHSEEDTSQNTATHETGTSSDSTSSV
LGPHTDNMICAVSKASLDSVFSDKLHSKYELQQIKHEPIASVRIKEEPVNVNIPEKTTALNNMDGKNVKAKLDHVQFAEFKIDMDSKFEN

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:77166962/chr7:77365727)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPN12chr7:77256992chr7:77365726ENST00000248594+131828_293665.3333333333334781.0DomainTyrosine-protein phosphatase
HgenePTPN12chr7:77256992chr7:77365726ENST00000435495+121728_293535.3333333333334651.0DomainTyrosine-protein phosphatase
HgenePTPN12chr7:77256992chr7:77365727ENST00000248594+131828_293665.3333333333334781.0DomainTyrosine-protein phosphatase
HgenePTPN12chr7:77256992chr7:77365727ENST00000435495+121728_293535.3333333333334651.0DomainTyrosine-protein phosphatase
HgenePTPN12chr7:77256992chr7:77378740ENST00000248594+131828_293665.3333333333334781.0DomainTyrosine-protein phosphatase
HgenePTPN12chr7:77256992chr7:77378740ENST00000435495+121728_293535.3333333333334651.0DomainTyrosine-protein phosphatase
HgenePTPN12chr7:77256992chr7:77378741ENST00000248594+131828_293665.3333333333334781.0DomainTyrosine-protein phosphatase
HgenePTPN12chr7:77256992chr7:77378741ENST00000435495+121728_293535.3333333333334651.0DomainTyrosine-protein phosphatase
HgenePTPN12chr7:77200503chr7:77365726ENST00000248594+21863_6769.33333333333333781.0RegionSubstrate binding
HgenePTPN12chr7:77256992chr7:77365726ENST00000248594+1318231_237665.3333333333334781.0RegionSubstrate binding
HgenePTPN12chr7:77256992chr7:77365726ENST00000248594+131863_67665.3333333333334781.0RegionSubstrate binding
HgenePTPN12chr7:77256992chr7:77365726ENST00000435495+1217231_237535.3333333333334651.0RegionSubstrate binding
HgenePTPN12chr7:77256992chr7:77365726ENST00000435495+121763_67535.3333333333334651.0RegionSubstrate binding
HgenePTPN12chr7:77256992chr7:77365727ENST00000248594+1318231_237665.3333333333334781.0RegionSubstrate binding
HgenePTPN12chr7:77256992chr7:77365727ENST00000248594+131863_67665.3333333333334781.0RegionSubstrate binding
HgenePTPN12chr7:77256992chr7:77365727ENST00000435495+1217231_237535.3333333333334651.0RegionSubstrate binding
HgenePTPN12chr7:77256992chr7:77365727ENST00000435495+121763_67535.3333333333334651.0RegionSubstrate binding
HgenePTPN12chr7:77256992chr7:77378740ENST00000248594+1318231_237665.3333333333334781.0RegionSubstrate binding
HgenePTPN12chr7:77256992chr7:77378740ENST00000248594+131863_67665.3333333333334781.0RegionSubstrate binding
HgenePTPN12chr7:77256992chr7:77378740ENST00000435495+1217231_237535.3333333333334651.0RegionSubstrate binding
HgenePTPN12chr7:77256992chr7:77378740ENST00000435495+121763_67535.3333333333334651.0RegionSubstrate binding
HgenePTPN12chr7:77256992chr7:77378741ENST00000248594+1318231_237665.3333333333334781.0RegionSubstrate binding
HgenePTPN12chr7:77256992chr7:77378741ENST00000248594+131863_67665.3333333333334781.0RegionSubstrate binding
HgenePTPN12chr7:77256992chr7:77378741ENST00000435495+1217231_237535.3333333333334651.0RegionSubstrate binding
HgenePTPN12chr7:77256992chr7:77378741ENST00000435495+121763_67535.3333333333334651.0RegionSubstrate binding
TgeneRSBN1Lchr7:77166962chr7:77394812ENST0000044528828197_274178.0577.0Compositional biasNote=Lys-rich
TgeneRSBN1Lchr7:77200503chr7:77365726ENST0000033495508197_274195.33333333333334847.0Compositional biasNote=Lys-rich
TgeneRSBN1Lchr7:77200503chr7:77365726ENST000004452880812_150577.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77200503chr7:77365726ENST0000044528808146_1550577.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77200503chr7:77365726ENST0000044528808197_2740577.0Compositional biasNote=Lys-rich
TgeneRSBN1Lchr7:77200503chr7:77365726ENST000004452880876_1210577.0Compositional biasNote=Ser-rich
TgeneRSBN1Lchr7:77256992chr7:77365726ENST0000033495508197_274195.33333333333334847.0Compositional biasNote=Lys-rich
TgeneRSBN1Lchr7:77256992chr7:77365726ENST000004452880812_150577.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77256992chr7:77365726ENST0000044528808146_1550577.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77256992chr7:77365726ENST0000044528808197_2740577.0Compositional biasNote=Lys-rich
TgeneRSBN1Lchr7:77256992chr7:77365726ENST000004452880876_1210577.0Compositional biasNote=Ser-rich
TgeneRSBN1Lchr7:77256992chr7:77365727ENST0000033495508197_274195.33333333333334847.0Compositional biasNote=Lys-rich
TgeneRSBN1Lchr7:77256992chr7:77365727ENST000004452880812_150577.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77256992chr7:77365727ENST0000044528808146_1550577.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77256992chr7:77365727ENST0000044528808197_2740577.0Compositional biasNote=Lys-rich
TgeneRSBN1Lchr7:77256992chr7:77365727ENST000004452880876_1210577.0Compositional biasNote=Ser-rich
TgeneRSBN1Lchr7:77256992chr7:77378740ENST000004452881812_150577.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77256992chr7:77378740ENST0000044528818146_1550577.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77256992chr7:77378740ENST0000044528818197_2740577.0Compositional biasNote=Lys-rich
TgeneRSBN1Lchr7:77256992chr7:77378740ENST000004452881876_1210577.0Compositional biasNote=Ser-rich
TgeneRSBN1Lchr7:77256992chr7:77378741ENST000004452881812_150577.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77256992chr7:77378741ENST0000044528818146_1550577.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77256992chr7:77378741ENST0000044528818197_2740577.0Compositional biasNote=Lys-rich
TgeneRSBN1Lchr7:77256992chr7:77378741ENST000004452881876_1210577.0Compositional biasNote=Ser-rich

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPN12chr7:77166962chr7:77394812ENST00000248594+11828_29333.0781.0DomainTyrosine-protein phosphatase
HgenePTPN12chr7:77166962chr7:77394812ENST00000435495+11728_2930651.0DomainTyrosine-protein phosphatase
HgenePTPN12chr7:77200503chr7:77365726ENST00000248594+21828_29369.33333333333333781.0DomainTyrosine-protein phosphatase
HgenePTPN12chr7:77200503chr7:77365726ENST00000435495+21728_2930651.0DomainTyrosine-protein phosphatase
HgenePTPN12chr7:77166962chr7:77394812ENST00000248594+118231_23733.0781.0RegionSubstrate binding
HgenePTPN12chr7:77166962chr7:77394812ENST00000248594+11863_6733.0781.0RegionSubstrate binding
HgenePTPN12chr7:77166962chr7:77394812ENST00000435495+117231_2370651.0RegionSubstrate binding
HgenePTPN12chr7:77166962chr7:77394812ENST00000435495+11763_670651.0RegionSubstrate binding
HgenePTPN12chr7:77200503chr7:77365726ENST00000248594+218231_23769.33333333333333781.0RegionSubstrate binding
HgenePTPN12chr7:77200503chr7:77365726ENST00000435495+217231_2370651.0RegionSubstrate binding
HgenePTPN12chr7:77200503chr7:77365726ENST00000435495+21763_670651.0RegionSubstrate binding
TgeneRSBN1Lchr7:77166962chr7:77394812ENST000003349552812_15448.0847.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77166962chr7:77394812ENST0000033495528146_155448.0847.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77166962chr7:77394812ENST0000033495528197_274448.0847.0Compositional biasNote=Lys-rich
TgeneRSBN1Lchr7:77166962chr7:77394812ENST000003349552876_121448.0847.0Compositional biasNote=Ser-rich
TgeneRSBN1Lchr7:77166962chr7:77394812ENST000004452882812_15178.0577.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77166962chr7:77394812ENST0000044528828146_155178.0577.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77166962chr7:77394812ENST000004452882876_121178.0577.0Compositional biasNote=Ser-rich
TgeneRSBN1Lchr7:77200503chr7:77365726ENST000003349550812_15195.33333333333334847.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77200503chr7:77365726ENST0000033495508146_155195.33333333333334847.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77200503chr7:77365726ENST000003349550876_121195.33333333333334847.0Compositional biasNote=Ser-rich
TgeneRSBN1Lchr7:77256992chr7:77365726ENST000003349550812_15195.33333333333334847.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77256992chr7:77365726ENST0000033495508146_155195.33333333333334847.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77256992chr7:77365726ENST000003349550876_121195.33333333333334847.0Compositional biasNote=Ser-rich
TgeneRSBN1Lchr7:77256992chr7:77365727ENST000003349550812_15195.33333333333334847.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77256992chr7:77365727ENST0000033495508146_155195.33333333333334847.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77256992chr7:77365727ENST000003349550876_121195.33333333333334847.0Compositional biasNote=Ser-rich
TgeneRSBN1Lchr7:77256992chr7:77378740ENST000003349551812_15234.33333333333334847.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77256992chr7:77378740ENST0000033495518146_155234.33333333333334847.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77256992chr7:77378740ENST0000033495518197_274234.33333333333334847.0Compositional biasNote=Lys-rich
TgeneRSBN1Lchr7:77256992chr7:77378740ENST000003349551876_121234.33333333333334847.0Compositional biasNote=Ser-rich
TgeneRSBN1Lchr7:77256992chr7:77378741ENST000003349551812_15234.33333333333334847.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77256992chr7:77378741ENST0000033495518146_155234.33333333333334847.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr7:77256992chr7:77378741ENST0000033495518197_274234.33333333333334847.0Compositional biasNote=Lys-rich
TgeneRSBN1Lchr7:77256992chr7:77378741ENST000003349551876_121234.33333333333334847.0Compositional biasNote=Ser-rich


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PTPN12
RSBN1L


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePTPN12chr7:77166962chr7:77394812ENST00000248594+118345_43833.0781.0TGFB1I1
HgenePTPN12chr7:77166962chr7:77394812ENST00000435495+117345_4380651.0TGFB1I1
HgenePTPN12chr7:77200503chr7:77365726ENST00000248594+218345_43869.33333333333333781.0TGFB1I1
HgenePTPN12chr7:77200503chr7:77365726ENST00000435495+217345_4380651.0TGFB1I1


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Related Drugs to PTPN12-RSBN1L


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PTPN12-RSBN1L


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource