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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ASCC1-MICU1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ASCC1-MICU1
	FusionPDB ID: 7031
	FusionGDB2.0 ID: 7031
		Hgene	Tgene
	Gene symbol	ASCC1	MICU1
	Gene ID	51008	10367
	Gene name	activating signal cointegrator 1 complex subunit 1	mitochondrial calcium uptake 1
	Synonyms	ASC1p50\|CGI-18\|SMABF2\|p50	CALC\|CBARA1\|EFHA3\|MPXPS\|ara CALC
	Cytomap	10q22.1	10q22.1
	Type of gene	protein-coding	protein-coding
	Description	activating signal cointegrator 1 complex subunit 1ASC-1 complex subunit P50trip4 complex subunit p50	calcium uptake protein 1, mitochondrialatopy-related autoantigen CALCcalcium-binding atopy-related autoantigen 1
	Modification date	20200313	20200313
	UniProtAcc	Q8N9N2	Q9BPX6
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000317126, ENST00000317168, ENST00000342444, ENST00000394915, ENST00000394919, ENST00000545550, ENST00000492502,	ENST00000361114, ENST00000398761, ENST00000398763, ENST00000401998, ENST00000418483, ENST00000604025,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 11 X 6=528	22 X 15 X 11=3630
	# samples	15	30
	** MAII score	log2(15/528*10)=-1.81557542886257 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(30/3630*10)=-3.59693514238723 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ASCC1 [Title/Abstract] AND MICU1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ASCC1(73956569)-MICU1(74135630), # samples:6 MICU1(74385768)-ASCC1(73892939), # samples:1
Anticipated loss of major functional domain due to fusion event.	ASCC1-MICU1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ASCC1-MICU1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ASCC1-MICU1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ASCC1-MICU1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ASCC1-MICU1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ASCC1-MICU1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ASCC1	GO:0006355	regulation of transcription, DNA-templated	12077347
Tgene	MICU1	GO:0006851	mitochondrial calcium ion transmembrane transport	24560927
Tgene	MICU1	GO:0051260	protein homooligomerization	24514027
Tgene	MICU1	GO:0051561	positive regulation of mitochondrial calcium ion concentration	24560927
Tgene	MICU1	GO:0070509	calcium ion import	20693986

Fusion gene breakpoints across ASCC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MICU1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A7-A13D-01A	ASCC1	chr10	73956569	-	MICU1	chr10	74135630	-
ChimerDB4	BRCA	TCGA-A8-A07O-01A	ASCC1	chr10	73892815	-	MICU1	chr10	74135630	-
ChimerDB4	BRCA	TCGA-E9-A1RB-01A	ASCC1	chr10	73956569	-	MICU1	chr10	74167795	-
ChimerDB4	BRCA	TCGA-OL-A66I-01A	ASCC1	chr10	73956569	-	MICU1	chr10	74183129	-
ChimerDB4	CESC	TCGA-C5-A7UC-01A	ASCC1	chr10	73956569	-	MICU1	chr10	74135630	-
ChimerDB4	CESC	TCGA-C5-A7UC-01A	ASCC1	chr10	73956569	-	MICU1	chr10	74139341	-
ChimerDB4	HNSC	TCGA-CV-6953-01A	ASCC1	chr10	73956569	-	MICU1	chr10	74167795	-
ChimerDB4	STAD	TCGA-CG-4449-01A	ASCC1	chr10	73956569	-	MICU1	chr10	74135630	-
ChimerDB4	STAD	TCGA-HU-A4GH-01A	ASCC1	chr10	73956569	-	MICU1	chr10	74135630	-
ChimerDB4	STAD	TCGA-HU-A4GH	ASCC1	chr10	73956568	-	MICU1	chr10	74135630	-
ChimerDB4	UCS	TCGA-N5-A4RU-01A	ASCC1	chr10	73972945	-	MICU1	chr10	74183129	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000394919	ASCC1	chr10	73956569	-	ENST00000401998	MICU1	chr10	74135630	-	1783	677	1199	609	196
ENST00000394919	ASCC1	chr10	73956569	-	ENST00000361114	MICU1	chr10	74135630	-	1783	677	1199	609	196
ENST00000394919	ASCC1	chr10	73956569	-	ENST00000398761	MICU1	chr10	74135630	-	1783	677	1199	609	196
ENST00000394919	ASCC1	chr10	73956569	-	ENST00000418483	MICU1	chr10	74135630	-	1209	677	1199	609	196
ENST00000394919	ASCC1	chr10	73956569	-	ENST00000398763	MICU1	chr10	74135630	-	1012	677	104	679	191
ENST00000342444	ASCC1	chr10	73892815	-	ENST00000401998	MICU1	chr10	74135630	-	2163	1057	63	1307	414
ENST00000342444	ASCC1	chr10	73892815	-	ENST00000361114	MICU1	chr10	74135630	-	2163	1057	63	1307	414
ENST00000342444	ASCC1	chr10	73892815	-	ENST00000398761	MICU1	chr10	74135630	-	2163	1057	63	1307	414
ENST00000342444	ASCC1	chr10	73892815	-	ENST00000418483	MICU1	chr10	74135630	-	1589	1057	63	1307	414
ENST00000342444	ASCC1	chr10	73892815	-	ENST00000398763	MICU1	chr10	74135630	-	1392	1057	63	1307	414
ENST00000545550	ASCC1	chr10	73892815	-	ENST00000401998	MICU1	chr10	74135630	-	2324	1218	278	1468	396
ENST00000545550	ASCC1	chr10	73892815	-	ENST00000361114	MICU1	chr10	74135630	-	2324	1218	278	1468	396
ENST00000545550	ASCC1	chr10	73892815	-	ENST00000398761	MICU1	chr10	74135630	-	2324	1218	278	1468	396
ENST00000545550	ASCC1	chr10	73892815	-	ENST00000418483	MICU1	chr10	74135630	-	1750	1218	278	1468	396
ENST00000545550	ASCC1	chr10	73892815	-	ENST00000398763	MICU1	chr10	74135630	-	1553	1218	278	1468	396
ENST00000317126	ASCC1	chr10	73892815	-	ENST00000401998	MICU1	chr10	74135630	-	2324	1218	278	1468	396
ENST00000317126	ASCC1	chr10	73892815	-	ENST00000361114	MICU1	chr10	74135630	-	2324	1218	278	1468	396
ENST00000317126	ASCC1	chr10	73892815	-	ENST00000398761	MICU1	chr10	74135630	-	2324	1218	278	1468	396
ENST00000317126	ASCC1	chr10	73892815	-	ENST00000418483	MICU1	chr10	74135630	-	1750	1218	278	1468	396
ENST00000317126	ASCC1	chr10	73892815	-	ENST00000398763	MICU1	chr10	74135630	-	1553	1218	278	1468	396
ENST00000342444	ASCC1	chr10	73956569	-	ENST00000401998	MICU1	chr10	74167795	-	1890	675	63	1034	323
ENST00000342444	ASCC1	chr10	73956569	-	ENST00000361114	MICU1	chr10	74167795	-	1890	675	63	1034	323
ENST00000342444	ASCC1	chr10	73956569	-	ENST00000398761	MICU1	chr10	74167795	-	1890	675	63	1034	323
ENST00000342444	ASCC1	chr10	73956569	-	ENST00000418483	MICU1	chr10	74167795	-	1316	675	63	1034	323
ENST00000342444	ASCC1	chr10	73956569	-	ENST00000398763	MICU1	chr10	74167795	-	1119	675	63	1034	323
ENST00000545550	ASCC1	chr10	73956569	-	ENST00000401998	MICU1	chr10	74167795	-	2051	836	278	1195	305
ENST00000545550	ASCC1	chr10	73956569	-	ENST00000361114	MICU1	chr10	74167795	-	2051	836	278	1195	305
ENST00000545550	ASCC1	chr10	73956569	-	ENST00000398761	MICU1	chr10	74167795	-	2051	836	278	1195	305
ENST00000545550	ASCC1	chr10	73956569	-	ENST00000418483	MICU1	chr10	74167795	-	1477	836	278	1195	305
ENST00000545550	ASCC1	chr10	73956569	-	ENST00000398763	MICU1	chr10	74167795	-	1280	836	278	1195	305
ENST00000317126	ASCC1	chr10	73956569	-	ENST00000401998	MICU1	chr10	74167795	-	2051	836	278	1195	305
ENST00000317126	ASCC1	chr10	73956569	-	ENST00000361114	MICU1	chr10	74167795	-	2051	836	278	1195	305
ENST00000317126	ASCC1	chr10	73956569	-	ENST00000398761	MICU1	chr10	74167795	-	2051	836	278	1195	305
ENST00000317126	ASCC1	chr10	73956569	-	ENST00000418483	MICU1	chr10	74167795	-	1477	836	278	1195	305
ENST00000317126	ASCC1	chr10	73956569	-	ENST00000398763	MICU1	chr10	74167795	-	1280	836	278	1195	305
ENST00000342444	ASCC1	chr10	73956569	-	ENST00000401998	MICU1	chr10	74183129	-	2028	675	63	1172	369
ENST00000342444	ASCC1	chr10	73956569	-	ENST00000361114	MICU1	chr10	74183129	-	2028	675	63	1172	369
ENST00000342444	ASCC1	chr10	73956569	-	ENST00000398761	MICU1	chr10	74183129	-	2028	675	63	1172	369
ENST00000342444	ASCC1	chr10	73956569	-	ENST00000418483	MICU1	chr10	74183129	-	1454	675	63	1172	369
ENST00000342444	ASCC1	chr10	73956569	-	ENST00000398763	MICU1	chr10	74183129	-	1257	675	63	1172	369
ENST00000545550	ASCC1	chr10	73956569	-	ENST00000401998	MICU1	chr10	74183129	-	2189	836	278	1333	351
ENST00000545550	ASCC1	chr10	73956569	-	ENST00000361114	MICU1	chr10	74183129	-	2189	836	278	1333	351
ENST00000545550	ASCC1	chr10	73956569	-	ENST00000398761	MICU1	chr10	74183129	-	2189	836	278	1333	351
ENST00000545550	ASCC1	chr10	73956569	-	ENST00000418483	MICU1	chr10	74183129	-	1615	836	278	1333	351
ENST00000545550	ASCC1	chr10	73956569	-	ENST00000398763	MICU1	chr10	74183129	-	1418	836	278	1333	351
ENST00000317126	ASCC1	chr10	73956569	-	ENST00000401998	MICU1	chr10	74183129	-	2189	836	278	1333	351
ENST00000317126	ASCC1	chr10	73956569	-	ENST00000361114	MICU1	chr10	74183129	-	2189	836	278	1333	351
ENST00000317126	ASCC1	chr10	73956569	-	ENST00000398761	MICU1	chr10	74183129	-	2189	836	278	1333	351
ENST00000317126	ASCC1	chr10	73956569	-	ENST00000418483	MICU1	chr10	74183129	-	1615	836	278	1333	351
ENST00000317126	ASCC1	chr10	73956569	-	ENST00000398763	MICU1	chr10	74183129	-	1418	836	278	1333	351
ENST00000342444	ASCC1	chr10	73972945	-	ENST00000401998	MICU1	chr10	74183129	-	1567	214	133	711	192
ENST00000342444	ASCC1	chr10	73972945	-	ENST00000361114	MICU1	chr10	74183129	-	1567	214	133	711	192
ENST00000342444	ASCC1	chr10	73972945	-	ENST00000398761	MICU1	chr10	74183129	-	1567	214	133	711	192
ENST00000342444	ASCC1	chr10	73972945	-	ENST00000418483	MICU1	chr10	74183129	-	993	214	133	711	192
ENST00000342444	ASCC1	chr10	73972945	-	ENST00000398763	MICU1	chr10	74183129	-	796	214	133	711	192
ENST00000317168	ASCC1	chr10	73972945	-	ENST00000401998	MICU1	chr10	74183129	-	1580	227	146	724	192
ENST00000317168	ASCC1	chr10	73972945	-	ENST00000361114	MICU1	chr10	74183129	-	1580	227	146	724	192
ENST00000317168	ASCC1	chr10	73972945	-	ENST00000398761	MICU1	chr10	74183129	-	1580	227	146	724	192
ENST00000317168	ASCC1	chr10	73972945	-	ENST00000418483	MICU1	chr10	74183129	-	1006	227	146	724	192
ENST00000317168	ASCC1	chr10	73972945	-	ENST00000398763	MICU1	chr10	74183129	-	809	227	146	724	192
ENST00000394915	ASCC1	chr10	73972945	-	ENST00000401998	MICU1	chr10	74183129	-	1573	220	139	717	192
ENST00000394915	ASCC1	chr10	73972945	-	ENST00000361114	MICU1	chr10	74183129	-	1573	220	139	717	192
ENST00000394915	ASCC1	chr10	73972945	-	ENST00000398761	MICU1	chr10	74183129	-	1573	220	139	717	192
ENST00000394915	ASCC1	chr10	73972945	-	ENST00000418483	MICU1	chr10	74183129	-	999	220	139	717	192
ENST00000394915	ASCC1	chr10	73972945	-	ENST00000398763	MICU1	chr10	74183129	-	802	220	139	717	192
ENST00000394919	ASCC1	chr10	73956568	-	ENST00000401998	MICU1	chr10	74135630	-	1783	677	1199	609	196
ENST00000394919	ASCC1	chr10	73956568	-	ENST00000361114	MICU1	chr10	74135630	-	1783	677	1199	609	196
ENST00000394919	ASCC1	chr10	73956568	-	ENST00000398761	MICU1	chr10	74135630	-	1783	677	1199	609	196
ENST00000394919	ASCC1	chr10	73956568	-	ENST00000418483	MICU1	chr10	74135630	-	1209	677	1199	609	196
ENST00000394919	ASCC1	chr10	73956568	-	ENST00000398763	MICU1	chr10	74135630	-	1012	677	104	679	191

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000394919	ENST00000401998	ASCC1	chr10	73956569	-	MICU1	chr10	74135630	-	0.003601794	0.9963982
ENST00000394919	ENST00000361114	ASCC1	chr10	73956569	-	MICU1	chr10	74135630	-	0.003601794	0.9963982
ENST00000394919	ENST00000398761	ASCC1	chr10	73956569	-	MICU1	chr10	74135630	-	0.003601794	0.9963982
ENST00000394919	ENST00000418483	ASCC1	chr10	73956569	-	MICU1	chr10	74135630	-	0.003879896	0.9961201
ENST00000394919	ENST00000398763	ASCC1	chr10	73956569	-	MICU1	chr10	74135630	-	0.004903544	0.9950964
ENST00000342444	ENST00000401998	ASCC1	chr10	73892815	-	MICU1	chr10	74135630	-	0.002488642	0.9975114
ENST00000342444	ENST00000361114	ASCC1	chr10	73892815	-	MICU1	chr10	74135630	-	0.002488642	0.9975114
ENST00000342444	ENST00000398761	ASCC1	chr10	73892815	-	MICU1	chr10	74135630	-	0.002488642	0.9975114
ENST00000342444	ENST00000418483	ASCC1	chr10	73892815	-	MICU1	chr10	74135630	-	0.002475049	0.9975249
ENST00000342444	ENST00000398763	ASCC1	chr10	73892815	-	MICU1	chr10	74135630	-	0.003112053	0.996888
ENST00000545550	ENST00000401998	ASCC1	chr10	73892815	-	MICU1	chr10	74135630	-	0.001518025	0.99848205
ENST00000545550	ENST00000361114	ASCC1	chr10	73892815	-	MICU1	chr10	74135630	-	0.001518025	0.99848205
ENST00000545550	ENST00000398761	ASCC1	chr10	73892815	-	MICU1	chr10	74135630	-	0.001518025	0.99848205
ENST00000545550	ENST00000418483	ASCC1	chr10	73892815	-	MICU1	chr10	74135630	-	0.001681097	0.99831885
ENST00000545550	ENST00000398763	ASCC1	chr10	73892815	-	MICU1	chr10	74135630	-	0.002180921	0.99781907
ENST00000317126	ENST00000401998	ASCC1	chr10	73892815	-	MICU1	chr10	74135630	-	0.001518025	0.99848205
ENST00000317126	ENST00000361114	ASCC1	chr10	73892815	-	MICU1	chr10	74135630	-	0.001518025	0.99848205
ENST00000317126	ENST00000398761	ASCC1	chr10	73892815	-	MICU1	chr10	74135630	-	0.001518025	0.99848205
ENST00000317126	ENST00000418483	ASCC1	chr10	73892815	-	MICU1	chr10	74135630	-	0.001681097	0.99831885
ENST00000317126	ENST00000398763	ASCC1	chr10	73892815	-	MICU1	chr10	74135630	-	0.002180921	0.99781907
ENST00000342444	ENST00000401998	ASCC1	chr10	73956569	-	MICU1	chr10	74167795	-	0.001870667	0.9981293
ENST00000342444	ENST00000361114	ASCC1	chr10	73956569	-	MICU1	chr10	74167795	-	0.001870667	0.9981293
ENST00000342444	ENST00000398761	ASCC1	chr10	73956569	-	MICU1	chr10	74167795	-	0.001870667	0.9981293
ENST00000342444	ENST00000418483	ASCC1	chr10	73956569	-	MICU1	chr10	74167795	-	0.001725627	0.9982743
ENST00000342444	ENST00000398763	ASCC1	chr10	73956569	-	MICU1	chr10	74167795	-	0.002294685	0.9977054
ENST00000545550	ENST00000401998	ASCC1	chr10	73956569	-	MICU1	chr10	74167795	-	0.001854597	0.99814546
ENST00000545550	ENST00000361114	ASCC1	chr10	73956569	-	MICU1	chr10	74167795	-	0.001854597	0.99814546
ENST00000545550	ENST00000398761	ASCC1	chr10	73956569	-	MICU1	chr10	74167795	-	0.001854597	0.99814546
ENST00000545550	ENST00000418483	ASCC1	chr10	73956569	-	MICU1	chr10	74167795	-	0.002054444	0.9979456
ENST00000545550	ENST00000398763	ASCC1	chr10	73956569	-	MICU1	chr10	74167795	-	0.002837652	0.9971623
ENST00000317126	ENST00000401998	ASCC1	chr10	73956569	-	MICU1	chr10	74167795	-	0.001854597	0.99814546
ENST00000317126	ENST00000361114	ASCC1	chr10	73956569	-	MICU1	chr10	74167795	-	0.001854597	0.99814546
ENST00000317126	ENST00000398761	ASCC1	chr10	73956569	-	MICU1	chr10	74167795	-	0.001854597	0.99814546
ENST00000317126	ENST00000418483	ASCC1	chr10	73956569	-	MICU1	chr10	74167795	-	0.002054444	0.9979456
ENST00000317126	ENST00000398763	ASCC1	chr10	73956569	-	MICU1	chr10	74167795	-	0.002837652	0.9971623
ENST00000342444	ENST00000401998	ASCC1	chr10	73956569	-	MICU1	chr10	74183129	-	0.001791276	0.99820876
ENST00000342444	ENST00000361114	ASCC1	chr10	73956569	-	MICU1	chr10	74183129	-	0.001791276	0.99820876
ENST00000342444	ENST00000398761	ASCC1	chr10	73956569	-	MICU1	chr10	74183129	-	0.001791276	0.99820876
ENST00000342444	ENST00000418483	ASCC1	chr10	73956569	-	MICU1	chr10	74183129	-	0.001740107	0.99825984
ENST00000342444	ENST00000398763	ASCC1	chr10	73956569	-	MICU1	chr10	74183129	-	0.002325651	0.9976744
ENST00000545550	ENST00000401998	ASCC1	chr10	73956569	-	MICU1	chr10	74183129	-	0.001879069	0.99812096
ENST00000545550	ENST00000361114	ASCC1	chr10	73956569	-	MICU1	chr10	74183129	-	0.001879069	0.99812096
ENST00000545550	ENST00000398761	ASCC1	chr10	73956569	-	MICU1	chr10	74183129	-	0.001879069	0.99812096
ENST00000545550	ENST00000418483	ASCC1	chr10	73956569	-	MICU1	chr10	74183129	-	0.0021348	0.99786526
ENST00000545550	ENST00000398763	ASCC1	chr10	73956569	-	MICU1	chr10	74183129	-	0.002772739	0.99722725
ENST00000317126	ENST00000401998	ASCC1	chr10	73956569	-	MICU1	chr10	74183129	-	0.001879069	0.99812096
ENST00000317126	ENST00000361114	ASCC1	chr10	73956569	-	MICU1	chr10	74183129	-	0.001879069	0.99812096
ENST00000317126	ENST00000398761	ASCC1	chr10	73956569	-	MICU1	chr10	74183129	-	0.001879069	0.99812096
ENST00000317126	ENST00000418483	ASCC1	chr10	73956569	-	MICU1	chr10	74183129	-	0.0021348	0.99786526
ENST00000317126	ENST00000398763	ASCC1	chr10	73956569	-	MICU1	chr10	74183129	-	0.002772739	0.99722725
ENST00000342444	ENST00000401998	ASCC1	chr10	73972945	-	MICU1	chr10	74183129	-	0.003358166	0.9966419
ENST00000342444	ENST00000361114	ASCC1	chr10	73972945	-	MICU1	chr10	74183129	-	0.003358166	0.9966419
ENST00000342444	ENST00000398761	ASCC1	chr10	73972945	-	MICU1	chr10	74183129	-	0.003358166	0.9966419
ENST00000342444	ENST00000418483	ASCC1	chr10	73972945	-	MICU1	chr10	74183129	-	0.003922198	0.99607784
ENST00000342444	ENST00000398763	ASCC1	chr10	73972945	-	MICU1	chr10	74183129	-	0.004853102	0.99514693
ENST00000317168	ENST00000401998	ASCC1	chr10	73972945	-	MICU1	chr10	74183129	-	0.004255587	0.9957444
ENST00000317168	ENST00000361114	ASCC1	chr10	73972945	-	MICU1	chr10	74183129	-	0.004255587	0.9957444
ENST00000317168	ENST00000398761	ASCC1	chr10	73972945	-	MICU1	chr10	74183129	-	0.004255587	0.9957444
ENST00000317168	ENST00000418483	ASCC1	chr10	73972945	-	MICU1	chr10	74183129	-	0.004688893	0.9953111
ENST00000317168	ENST00000398763	ASCC1	chr10	73972945	-	MICU1	chr10	74183129	-	0.005378842	0.99462116
ENST00000394915	ENST00000401998	ASCC1	chr10	73972945	-	MICU1	chr10	74183129	-	0.003340604	0.9966594
ENST00000394915	ENST00000361114	ASCC1	chr10	73972945	-	MICU1	chr10	74183129	-	0.003340604	0.9966594
ENST00000394915	ENST00000398761	ASCC1	chr10	73972945	-	MICU1	chr10	74183129	-	0.003340604	0.9966594
ENST00000394915	ENST00000418483	ASCC1	chr10	73972945	-	MICU1	chr10	74183129	-	0.003984607	0.99601537
ENST00000394915	ENST00000398763	ASCC1	chr10	73972945	-	MICU1	chr10	74183129	-	0.004991415	0.9950086
ENST00000394919	ENST00000401998	ASCC1	chr10	73956568	-	MICU1	chr10	74135630	-	0.003601794	0.9963982
ENST00000394919	ENST00000361114	ASCC1	chr10	73956568	-	MICU1	chr10	74135630	-	0.003601794	0.9963982
ENST00000394919	ENST00000398761	ASCC1	chr10	73956568	-	MICU1	chr10	74135630	-	0.003601794	0.9963982
ENST00000394919	ENST00000418483	ASCC1	chr10	73956568	-	MICU1	chr10	74135630	-	0.003879896	0.9961201
ENST00000394919	ENST00000398763	ASCC1	chr10	73956568	-	MICU1	chr10	74135630	-	0.004903544	0.9950964

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>7031_7031_1_ASCC1-MICU1_ASCC1_chr10_73892815_ENST00000317126_MICU1_chr10_74135630_ENST00000361114_length(amino acids)=396AA_BP=313
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYMNDDPGMVDVLYAKVHMKDGS
NRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQR

--------------------------------------------------------------

>7031_7031_2_ASCC1-MICU1_ASCC1_chr10_73892815_ENST00000317126_MICU1_chr10_74135630_ENST00000398761_length(amino acids)=396AA_BP=313
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYMNDDPGMVDVLYAKVHMKDGS
NRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQR

--------------------------------------------------------------

>7031_7031_3_ASCC1-MICU1_ASCC1_chr10_73892815_ENST00000317126_MICU1_chr10_74135630_ENST00000398763_length(amino acids)=396AA_BP=313
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYMNDDPGMVDVLYAKVHMKDGS
NRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQR

--------------------------------------------------------------

>7031_7031_4_ASCC1-MICU1_ASCC1_chr10_73892815_ENST00000317126_MICU1_chr10_74135630_ENST00000401998_length(amino acids)=396AA_BP=313
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYMNDDPGMVDVLYAKVHMKDGS
NRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQR

--------------------------------------------------------------

>7031_7031_5_ASCC1-MICU1_ASCC1_chr10_73892815_ENST00000317126_MICU1_chr10_74135630_ENST00000418483_length(amino acids)=396AA_BP=313
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYMNDDPGMVDVLYAKVHMKDGS
NRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQR

--------------------------------------------------------------

>7031_7031_6_ASCC1-MICU1_ASCC1_chr10_73892815_ENST00000342444_MICU1_chr10_74135630_ENST00000361114_length(amino acids)=414AA_BP=331
MQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPSLLYNLIHLNT
SNDCGFQKITLDCQNIYTWKSRHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAF
FLNEVEVQEGFLRFQEEVLAKCSMDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYMND
DPGMVDVLYAKVHMKDGSNRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNVTMQQVARTVAKVELSDHVCDVVFALFDC

--------------------------------------------------------------

>7031_7031_7_ASCC1-MICU1_ASCC1_chr10_73892815_ENST00000342444_MICU1_chr10_74135630_ENST00000398761_length(amino acids)=414AA_BP=331
MQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPSLLYNLIHLNT
SNDCGFQKITLDCQNIYTWKSRHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAF
FLNEVEVQEGFLRFQEEVLAKCSMDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYMND
DPGMVDVLYAKVHMKDGSNRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNVTMQQVARTVAKVELSDHVCDVVFALFDC

--------------------------------------------------------------

>7031_7031_8_ASCC1-MICU1_ASCC1_chr10_73892815_ENST00000342444_MICU1_chr10_74135630_ENST00000398763_length(amino acids)=414AA_BP=331
MQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPSLLYNLIHLNT
SNDCGFQKITLDCQNIYTWKSRHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAF
FLNEVEVQEGFLRFQEEVLAKCSMDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYMND
DPGMVDVLYAKVHMKDGSNRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNVTMQQVARTVAKVELSDHVCDVVFALFDC

--------------------------------------------------------------

>7031_7031_9_ASCC1-MICU1_ASCC1_chr10_73892815_ENST00000342444_MICU1_chr10_74135630_ENST00000401998_length(amino acids)=414AA_BP=331
MQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPSLLYNLIHLNT
SNDCGFQKITLDCQNIYTWKSRHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAF
FLNEVEVQEGFLRFQEEVLAKCSMDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYMND
DPGMVDVLYAKVHMKDGSNRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNVTMQQVARTVAKVELSDHVCDVVFALFDC

--------------------------------------------------------------

>7031_7031_10_ASCC1-MICU1_ASCC1_chr10_73892815_ENST00000342444_MICU1_chr10_74135630_ENST00000418483_length(amino acids)=414AA_BP=331
MQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPSLLYNLIHLNT
SNDCGFQKITLDCQNIYTWKSRHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAF
FLNEVEVQEGFLRFQEEVLAKCSMDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYMND
DPGMVDVLYAKVHMKDGSNRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNVTMQQVARTVAKVELSDHVCDVVFALFDC

--------------------------------------------------------------

>7031_7031_11_ASCC1-MICU1_ASCC1_chr10_73892815_ENST00000545550_MICU1_chr10_74135630_ENST00000361114_length(amino acids)=396AA_BP=313
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYMNDDPGMVDVLYAKVHMKDGS
NRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQR

--------------------------------------------------------------

>7031_7031_12_ASCC1-MICU1_ASCC1_chr10_73892815_ENST00000545550_MICU1_chr10_74135630_ENST00000398761_length(amino acids)=396AA_BP=313
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYMNDDPGMVDVLYAKVHMKDGS
NRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQR

--------------------------------------------------------------

>7031_7031_13_ASCC1-MICU1_ASCC1_chr10_73892815_ENST00000545550_MICU1_chr10_74135630_ENST00000398763_length(amino acids)=396AA_BP=313
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYMNDDPGMVDVLYAKVHMKDGS
NRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQR

--------------------------------------------------------------

>7031_7031_14_ASCC1-MICU1_ASCC1_chr10_73892815_ENST00000545550_MICU1_chr10_74135630_ENST00000401998_length(amino acids)=396AA_BP=313
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYMNDDPGMVDVLYAKVHMKDGS
NRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQR

--------------------------------------------------------------

>7031_7031_15_ASCC1-MICU1_ASCC1_chr10_73892815_ENST00000545550_MICU1_chr10_74135630_ENST00000418483_length(amino acids)=396AA_BP=313
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYMNDDPGMVDVLYAKVHMKDGS
NRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQR

--------------------------------------------------------------

>7031_7031_16_ASCC1-MICU1_ASCC1_chr10_73956568_ENST00000394919_MICU1_chr10_74135630_ENST00000361114_length(amino acids)=196AA_BP=0
MGGAVEADKCLSFTDLFMFLRTYGDTHWAESEPSRTRGRGRVKRGNRQSPEVIPGGRGTTSRSSSTKGSAETLRRGSRVLGVEGSPLAVW
GYCLGKAKSQAVSCAHFHMACMRRVKPMSLGFSRPLISRCFMMETNSLLLSSPLPSQSKSANTTSHTWSESSTLATVLATCCMVTWSTSP

--------------------------------------------------------------

>7031_7031_17_ASCC1-MICU1_ASCC1_chr10_73956568_ENST00000394919_MICU1_chr10_74135630_ENST00000398761_length(amino acids)=196AA_BP=0
MGGAVEADKCLSFTDLFMFLRTYGDTHWAESEPSRTRGRGRVKRGNRQSPEVIPGGRGTTSRSSSTKGSAETLRRGSRVLGVEGSPLAVW
GYCLGKAKSQAVSCAHFHMACMRRVKPMSLGFSRPLISRCFMMETNSLLLSSPLPSQSKSANTTSHTWSESSTLATVLATCCMVTWSTSP

--------------------------------------------------------------

>7031_7031_18_ASCC1-MICU1_ASCC1_chr10_73956568_ENST00000394919_MICU1_chr10_74135630_ENST00000398763_length(amino acids)=191AA_BP=
MQKDTAFLFLSKPPRSRGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRST
LRAPSLLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLR

--------------------------------------------------------------

>7031_7031_19_ASCC1-MICU1_ASCC1_chr10_73956568_ENST00000394919_MICU1_chr10_74135630_ENST00000401998_length(amino acids)=196AA_BP=0
MGGAVEADKCLSFTDLFMFLRTYGDTHWAESEPSRTRGRGRVKRGNRQSPEVIPGGRGTTSRSSSTKGSAETLRRGSRVLGVEGSPLAVW
GYCLGKAKSQAVSCAHFHMACMRRVKPMSLGFSRPLISRCFMMETNSLLLSSPLPSQSKSANTTSHTWSESSTLATVLATCCMVTWSTSP

--------------------------------------------------------------

>7031_7031_20_ASCC1-MICU1_ASCC1_chr10_73956568_ENST00000394919_MICU1_chr10_74135630_ENST00000418483_length(amino acids)=196AA_BP=0
MGGAVEADKCLSFTDLFMFLRTYGDTHWAESEPSRTRGRGRVKRGNRQSPEVIPGGRGTTSRSSSTKGSAETLRRGSRVLGVEGSPLAVW
GYCLGKAKSQAVSCAHFHMACMRRVKPMSLGFSRPLISRCFMMETNSLLLSSPLPSQSKSANTTSHTWSESSTLATVLATCCMVTWSTSP

--------------------------------------------------------------

>7031_7031_21_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000317126_MICU1_chr10_74167795_ENST00000361114_length(amino acids)=305AA_BP=186
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRL

--------------------------------------------------------------

>7031_7031_22_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000317126_MICU1_chr10_74167795_ENST00000398761_length(amino acids)=305AA_BP=186
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRL

--------------------------------------------------------------

>7031_7031_23_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000317126_MICU1_chr10_74167795_ENST00000398763_length(amino acids)=305AA_BP=186
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRL

--------------------------------------------------------------

>7031_7031_24_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000317126_MICU1_chr10_74167795_ENST00000401998_length(amino acids)=305AA_BP=186
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRL

--------------------------------------------------------------

>7031_7031_25_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000317126_MICU1_chr10_74167795_ENST00000418483_length(amino acids)=305AA_BP=186
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRL

--------------------------------------------------------------

>7031_7031_26_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000317126_MICU1_chr10_74183129_ENST00000361114_length(amino acids)=351AA_BP=184
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVT

--------------------------------------------------------------

>7031_7031_27_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000317126_MICU1_chr10_74183129_ENST00000398761_length(amino acids)=351AA_BP=184
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVT

--------------------------------------------------------------

>7031_7031_28_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000317126_MICU1_chr10_74183129_ENST00000398763_length(amino acids)=351AA_BP=184
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVT

--------------------------------------------------------------

>7031_7031_29_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000317126_MICU1_chr10_74183129_ENST00000401998_length(amino acids)=351AA_BP=184
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVT

--------------------------------------------------------------

>7031_7031_30_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000317126_MICU1_chr10_74183129_ENST00000418483_length(amino acids)=351AA_BP=184
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVT

--------------------------------------------------------------

>7031_7031_31_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000342444_MICU1_chr10_74167795_ENST00000361114_length(amino acids)=323AA_BP=204
MQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPSLLYNLIHLNT
SNDCGFQKITLDCQNIYTWKSRHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAF
FLNEVEVQEGFLRFQEEVLAKCSMGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCD

--------------------------------------------------------------

>7031_7031_32_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000342444_MICU1_chr10_74167795_ENST00000398761_length(amino acids)=323AA_BP=204
MQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPSLLYNLIHLNT
SNDCGFQKITLDCQNIYTWKSRHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAF
FLNEVEVQEGFLRFQEEVLAKCSMGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCD

--------------------------------------------------------------

>7031_7031_33_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000342444_MICU1_chr10_74167795_ENST00000398763_length(amino acids)=323AA_BP=204
MQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPSLLYNLIHLNT
SNDCGFQKITLDCQNIYTWKSRHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAF
FLNEVEVQEGFLRFQEEVLAKCSMGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCD

--------------------------------------------------------------

>7031_7031_34_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000342444_MICU1_chr10_74167795_ENST00000401998_length(amino acids)=323AA_BP=204
MQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPSLLYNLIHLNT
SNDCGFQKITLDCQNIYTWKSRHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAF
FLNEVEVQEGFLRFQEEVLAKCSMGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCD

--------------------------------------------------------------

>7031_7031_35_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000342444_MICU1_chr10_74167795_ENST00000418483_length(amino acids)=323AA_BP=204
MQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPSLLYNLIHLNT
SNDCGFQKITLDCQNIYTWKSRHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAF
FLNEVEVQEGFLRFQEEVLAKCSMGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCD

--------------------------------------------------------------

>7031_7031_36_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000342444_MICU1_chr10_74183129_ENST00000361114_length(amino acids)=369AA_BP=202
MQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPSLLYNLIHLNT
SNDCGFQKITLDCQNIYTWKSRHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAF
FLNEVEVQEGFLRFQEEVLAKCSMFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDV
DTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCAQET

--------------------------------------------------------------

>7031_7031_37_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000342444_MICU1_chr10_74183129_ENST00000398761_length(amino acids)=369AA_BP=202
MQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPSLLYNLIHLNT
SNDCGFQKITLDCQNIYTWKSRHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAF
FLNEVEVQEGFLRFQEEVLAKCSMFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDV
DTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCAQET

--------------------------------------------------------------

>7031_7031_38_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000342444_MICU1_chr10_74183129_ENST00000398763_length(amino acids)=369AA_BP=202
MQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPSLLYNLIHLNT
SNDCGFQKITLDCQNIYTWKSRHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAF
FLNEVEVQEGFLRFQEEVLAKCSMFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDV
DTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCAQET

--------------------------------------------------------------

>7031_7031_39_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000342444_MICU1_chr10_74183129_ENST00000401998_length(amino acids)=369AA_BP=202
MQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPSLLYNLIHLNT
SNDCGFQKITLDCQNIYTWKSRHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAF
FLNEVEVQEGFLRFQEEVLAKCSMFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDV
DTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCAQET

--------------------------------------------------------------

>7031_7031_40_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000342444_MICU1_chr10_74183129_ENST00000418483_length(amino acids)=369AA_BP=202
MQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPSLLYNLIHLNT
SNDCGFQKITLDCQNIYTWKSRHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAF
FLNEVEVQEGFLRFQEEVLAKCSMFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDV
DTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCAQET

--------------------------------------------------------------

>7031_7031_41_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000394919_MICU1_chr10_74135630_ENST00000361114_length(amino acids)=196AA_BP=0
MGGAVEADKCLSFTDLFMFLRTYGDTHWAESEPSRTRGRGRVKRGNRQSPEVIPGGRGTTSRSSSTKGSAETLRRGSRVLGVEGSPLAVW
GYCLGKAKSQAVSCAHFHMACMRRVKPMSLGFSRPLISRCFMMETNSLLLSSPLPSQSKSANTTSHTWSESSTLATVLATCCMVTWSTSP

--------------------------------------------------------------

>7031_7031_42_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000394919_MICU1_chr10_74135630_ENST00000398761_length(amino acids)=196AA_BP=0
MGGAVEADKCLSFTDLFMFLRTYGDTHWAESEPSRTRGRGRVKRGNRQSPEVIPGGRGTTSRSSSTKGSAETLRRGSRVLGVEGSPLAVW
GYCLGKAKSQAVSCAHFHMACMRRVKPMSLGFSRPLISRCFMMETNSLLLSSPLPSQSKSANTTSHTWSESSTLATVLATCCMVTWSTSP

--------------------------------------------------------------

>7031_7031_43_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000394919_MICU1_chr10_74135630_ENST00000398763_length(amino acids)=191AA_BP=
MQKDTAFLFLSKPPRSRGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRST
LRAPSLLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLR

--------------------------------------------------------------

>7031_7031_44_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000394919_MICU1_chr10_74135630_ENST00000401998_length(amino acids)=196AA_BP=0
MGGAVEADKCLSFTDLFMFLRTYGDTHWAESEPSRTRGRGRVKRGNRQSPEVIPGGRGTTSRSSSTKGSAETLRRGSRVLGVEGSPLAVW
GYCLGKAKSQAVSCAHFHMACMRRVKPMSLGFSRPLISRCFMMETNSLLLSSPLPSQSKSANTTSHTWSESSTLATVLATCCMVTWSTSP

--------------------------------------------------------------

>7031_7031_45_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000394919_MICU1_chr10_74135630_ENST00000418483_length(amino acids)=196AA_BP=0
MGGAVEADKCLSFTDLFMFLRTYGDTHWAESEPSRTRGRGRVKRGNRQSPEVIPGGRGTTSRSSSTKGSAETLRRGSRVLGVEGSPLAVW
GYCLGKAKSQAVSCAHFHMACMRRVKPMSLGFSRPLISRCFMMETNSLLLSSPLPSQSKSANTTSHTWSESSTLATVLATCCMVTWSTSP

--------------------------------------------------------------

>7031_7031_46_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000545550_MICU1_chr10_74167795_ENST00000361114_length(amino acids)=305AA_BP=186
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRL

--------------------------------------------------------------

>7031_7031_47_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000545550_MICU1_chr10_74167795_ENST00000398761_length(amino acids)=305AA_BP=186
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRL

--------------------------------------------------------------

>7031_7031_48_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000545550_MICU1_chr10_74167795_ENST00000398763_length(amino acids)=305AA_BP=186
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRL

--------------------------------------------------------------

>7031_7031_49_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000545550_MICU1_chr10_74167795_ENST00000401998_length(amino acids)=305AA_BP=186
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRL

--------------------------------------------------------------

>7031_7031_50_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000545550_MICU1_chr10_74167795_ENST00000418483_length(amino acids)=305AA_BP=186
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRL

--------------------------------------------------------------

>7031_7031_51_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000545550_MICU1_chr10_74183129_ENST00000361114_length(amino acids)=351AA_BP=184
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVT

--------------------------------------------------------------

>7031_7031_52_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000545550_MICU1_chr10_74183129_ENST00000398761_length(amino acids)=351AA_BP=184
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVT

--------------------------------------------------------------

>7031_7031_53_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000545550_MICU1_chr10_74183129_ENST00000398763_length(amino acids)=351AA_BP=184
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVT

--------------------------------------------------------------

>7031_7031_54_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000545550_MICU1_chr10_74183129_ENST00000401998_length(amino acids)=351AA_BP=184
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVT

--------------------------------------------------------------

>7031_7031_55_ASCC1-MICU1_ASCC1_chr10_73956569_ENST00000545550_MICU1_chr10_74183129_ENST00000418483_length(amino acids)=351AA_BP=184
MMMKYPGTWPCQGIIGISFGESVMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPS
LLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEV
LAKCSMFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVT

--------------------------------------------------------------

>7031_7031_56_ASCC1-MICU1_ASCC1_chr10_73972945_ENST00000317168_MICU1_chr10_74183129_ENST00000361114_length(amino acids)=192AA_BP=27
MMAGITGRIQSKNRPINMKKMKRTSIKFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNI
NDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCA

--------------------------------------------------------------

>7031_7031_57_ASCC1-MICU1_ASCC1_chr10_73972945_ENST00000317168_MICU1_chr10_74183129_ENST00000398761_length(amino acids)=192AA_BP=27
MMAGITGRIQSKNRPINMKKMKRTSIKFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNI
NDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCA

--------------------------------------------------------------

>7031_7031_58_ASCC1-MICU1_ASCC1_chr10_73972945_ENST00000317168_MICU1_chr10_74183129_ENST00000398763_length(amino acids)=192AA_BP=27
MMAGITGRIQSKNRPINMKKMKRTSIKFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNI
NDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCA

--------------------------------------------------------------

>7031_7031_59_ASCC1-MICU1_ASCC1_chr10_73972945_ENST00000317168_MICU1_chr10_74183129_ENST00000401998_length(amino acids)=192AA_BP=27
MMAGITGRIQSKNRPINMKKMKRTSIKFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNI
NDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCA

--------------------------------------------------------------

>7031_7031_60_ASCC1-MICU1_ASCC1_chr10_73972945_ENST00000317168_MICU1_chr10_74183129_ENST00000418483_length(amino acids)=192AA_BP=27
MMAGITGRIQSKNRPINMKKMKRTSIKFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNI
NDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCA

--------------------------------------------------------------

>7031_7031_61_ASCC1-MICU1_ASCC1_chr10_73972945_ENST00000342444_MICU1_chr10_74183129_ENST00000361114_length(amino acids)=192AA_BP=27
MMAGITGRIQSKNRPINMKKMKRTSIKFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNI
NDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCA

--------------------------------------------------------------

>7031_7031_62_ASCC1-MICU1_ASCC1_chr10_73972945_ENST00000342444_MICU1_chr10_74183129_ENST00000398761_length(amino acids)=192AA_BP=27
MMAGITGRIQSKNRPINMKKMKRTSIKFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNI
NDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCA

--------------------------------------------------------------

>7031_7031_63_ASCC1-MICU1_ASCC1_chr10_73972945_ENST00000342444_MICU1_chr10_74183129_ENST00000398763_length(amino acids)=192AA_BP=27
MMAGITGRIQSKNRPINMKKMKRTSIKFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNI
NDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCA

--------------------------------------------------------------

>7031_7031_64_ASCC1-MICU1_ASCC1_chr10_73972945_ENST00000342444_MICU1_chr10_74183129_ENST00000401998_length(amino acids)=192AA_BP=27
MMAGITGRIQSKNRPINMKKMKRTSIKFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNI
NDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCA

--------------------------------------------------------------

>7031_7031_65_ASCC1-MICU1_ASCC1_chr10_73972945_ENST00000342444_MICU1_chr10_74183129_ENST00000418483_length(amino acids)=192AA_BP=27
MMAGITGRIQSKNRPINMKKMKRTSIKFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNI
NDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCA

--------------------------------------------------------------

>7031_7031_66_ASCC1-MICU1_ASCC1_chr10_73972945_ENST00000394915_MICU1_chr10_74183129_ENST00000361114_length(amino acids)=192AA_BP=27
MMAGITGRIQSKNRPINMKKMKRTSIKFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNI
NDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCA

--------------------------------------------------------------

>7031_7031_67_ASCC1-MICU1_ASCC1_chr10_73972945_ENST00000394915_MICU1_chr10_74183129_ENST00000398761_length(amino acids)=192AA_BP=27
MMAGITGRIQSKNRPINMKKMKRTSIKFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNI
NDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCA

--------------------------------------------------------------

>7031_7031_68_ASCC1-MICU1_ASCC1_chr10_73972945_ENST00000394915_MICU1_chr10_74183129_ENST00000398763_length(amino acids)=192AA_BP=27
MMAGITGRIQSKNRPINMKKMKRTSIKFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNI
NDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCA

--------------------------------------------------------------

>7031_7031_69_ASCC1-MICU1_ASCC1_chr10_73972945_ENST00000394915_MICU1_chr10_74183129_ENST00000401998_length(amino acids)=192AA_BP=27
MMAGITGRIQSKNRPINMKKMKRTSIKFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNI
NDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCA

--------------------------------------------------------------

>7031_7031_70_ASCC1-MICU1_ASCC1_chr10_73972945_ENST00000394915_MICU1_chr10_74183129_ENST00000418483_length(amino acids)=192AA_BP=27
MMAGITGRIQSKNRPINMKKMKRTSIKFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNI
NDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCA

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:73956569/chr10:74135630)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ASCC1 Q8N9N2	MICU1 Q9BPX6
FUNCTION: Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29997253). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction. {ECO:0000269\|PubMed:12077347, ECO:0000269\|PubMed:19074642, ECO:0000269\|PubMed:26924529, ECO:0000269\|PubMed:29997253}.	FUNCTION: Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733). {ECO:0000269\|PubMed:16002733, ECO:0000269\|PubMed:20693986, ECO:0000269\|PubMed:22904319, ECO:0000269\|PubMed:23101630, ECO:0000269\|PubMed:23747253, ECO:0000269\|PubMed:24313810, ECO:0000269\|PubMed:24332854, ECO:0000269\|PubMed:24503055, ECO:0000269\|PubMed:24560927, ECO:0000269\|PubMed:26341627, ECO:0000269\|PubMed:26903221, ECO:0000269\|PubMed:27099988}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ASCC1

chr10:73892815

chr10:74135630

ENST00000317126

86_148

290.3333333333333

358.0

Domain

Hgene

ASCC1

chr10:73892815

chr10:74135630

ENST00000317168

86_148

290.3333333333333

358.0

Domain

Hgene

ASCC1

chr10:73892815

chr10:74135630

ENST00000342444

86_148

318.3333333333333

666.0

Domain

Hgene

ASCC1

chr10:73892815

chr10:74135630

ENST00000394915

86_148

318.3333333333333

401.0

Domain

Hgene

ASCC1

chr10:73892815

chr10:74135630

ENST00000394919

86_148

290.3333333333333

358.0

Domain

Hgene

ASCC1

chr10:73956568

chr10:74135630

ENST00000317126

86_148

163.0

358.0

Domain

Hgene

ASCC1

chr10:73956568

chr10:74135630

ENST00000317168

86_148

163.0

358.0

Domain

Hgene

ASCC1

chr10:73956568

chr10:74135630

ENST00000342444

86_148

191.0

666.0

Domain

Hgene

ASCC1

chr10:73956568

chr10:74135630

ENST00000394915

86_148

191.0

401.0

Domain

Hgene

ASCC1

chr10:73956568

chr10:74135630

ENST00000394919

86_148

163.0

358.0

Domain

Hgene

ASCC1

chr10:73956569

chr10:74135630

ENST00000317126

86_148

163.0

358.0

Domain

Hgene

ASCC1

chr10:73956569

chr10:74135630

ENST00000317168

86_148

163.0

358.0

Domain

Hgene

ASCC1

chr10:73956569

chr10:74135630

ENST00000342444

86_148

191.0

666.0

Domain

Hgene

ASCC1

chr10:73956569

chr10:74135630

ENST00000394915

86_148

191.0

401.0

Domain

Hgene

ASCC1

chr10:73956569

chr10:74135630

ENST00000394919

86_148

163.0

358.0

Domain

Hgene

ASCC1

chr10:73956569

chr10:74167795

ENST00000317126

86_148

163.0

358.0

Domain

Hgene

ASCC1

chr10:73956569

chr10:74167795

ENST00000317168

86_148

163.0

358.0

Domain

Hgene

ASCC1

chr10:73956569

chr10:74167795

ENST00000342444

86_148

191.0

666.0

Domain

Hgene

ASCC1

chr10:73956569

chr10:74167795

ENST00000394915

86_148

191.0

401.0

Domain

Hgene

ASCC1

chr10:73956569

chr10:74167795

ENST00000394919

86_148

163.0

358.0

Domain

Hgene

ASCC1

chr10:73956569

chr10:74183129

ENST00000317126

86_148

163.0

358.0

Domain

Hgene

ASCC1

chr10:73956569

chr10:74183129

ENST00000317168

86_148

163.0

358.0

Domain

Hgene

ASCC1

chr10:73956569

chr10:74183129

ENST00000342444

86_148

191.0

666.0

Domain

Hgene

ASCC1

chr10:73956569

chr10:74183129

ENST00000394915

86_148

191.0

401.0

Domain

Hgene

ASCC1

chr10:73956569

chr10:74183129

ENST00000394919

86_148

163.0

358.0

Domain

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000361114

421_432

393.3333333333333

477.0

Calcium binding

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000398763

231_242

195.33333333333334

279.0

Calcium binding

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000398763

421_432

195.33333333333334

279.0

Calcium binding

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000418483

231_242

195.33333333333334

279.0

Calcium binding

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000418483

421_432

195.33333333333334

279.0

Calcium binding

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000361114

421_432

393.3333333333333

477.0

Calcium binding

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000398763

231_242

195.33333333333334

279.0

Calcium binding

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000398763

421_432

195.33333333333334

279.0

Calcium binding

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000418483

231_242

195.33333333333334

279.0

Calcium binding

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000418483

421_432

195.33333333333334

279.0

Calcium binding

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000361114

421_432

393.3333333333333

477.0

Calcium binding

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000398763

231_242

195.33333333333334

279.0

Calcium binding

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000398763

421_432

195.33333333333334

279.0

Calcium binding

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000418483

231_242

195.33333333333334

279.0

Calcium binding

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000418483

421_432

195.33333333333334

279.0

Calcium binding

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000361114

421_432

357.0

477.0

Calcium binding

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000398763

231_242

159.0

279.0

Calcium binding

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000398763

421_432

159.0

279.0

Calcium binding

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000418483

231_242

159.0

279.0

Calcium binding

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000418483

421_432

159.0

279.0

Calcium binding

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000361114

421_432

311.0

477.0

Calcium binding

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000398763

231_242

113.0

279.0

Calcium binding

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000398763

421_432

113.0

279.0

Calcium binding

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000418483

231_242

113.0

279.0

Calcium binding

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000418483

421_432

113.0

279.0

Calcium binding

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000361114

421_432

311.0

477.0

Calcium binding

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000398763

231_242

113.0

279.0

Calcium binding

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000398763

421_432

113.0

279.0

Calcium binding

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000418483

231_242

113.0

279.0

Calcium binding

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000418483

421_432

113.0

279.0

Calcium binding

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000361114

408_443

393.3333333333333

477.0

Domain

EF-hand 2

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000398763

218_253

195.33333333333334

279.0

Domain

EF-hand 1

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000398763

408_443

195.33333333333334

279.0

Domain

EF-hand 2

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000418483

218_253

195.33333333333334

279.0

Domain

EF-hand 1

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000418483

408_443

195.33333333333334

279.0

Domain

EF-hand 2

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000361114

408_443

393.3333333333333

477.0

Domain

EF-hand 2

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000398763

218_253

195.33333333333334

279.0

Domain

EF-hand 1

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000398763

408_443

195.33333333333334

279.0

Domain

EF-hand 2

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000418483

218_253

195.33333333333334

279.0

Domain

EF-hand 1

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000418483

408_443

195.33333333333334

279.0

Domain

EF-hand 2

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000361114

408_443

393.3333333333333

477.0

Domain

EF-hand 2

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000398763

218_253

195.33333333333334

279.0

Domain

EF-hand 1

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000398763

408_443

195.33333333333334

279.0

Domain

EF-hand 2

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000418483

218_253

195.33333333333334

279.0

Domain

EF-hand 1

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000418483

408_443

195.33333333333334

279.0

Domain

EF-hand 2

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000361114

408_443

357.0

477.0

Domain

EF-hand 2

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000398763

218_253

159.0

279.0

Domain

EF-hand 1

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000398763

408_443

159.0

279.0

Domain

EF-hand 2

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000418483

218_253

159.0

279.0

Domain

EF-hand 1

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000418483

408_443

159.0

279.0

Domain

EF-hand 2

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000361114

408_443

311.0

477.0

Domain

EF-hand 2

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000398763

218_253

113.0

279.0

Domain

EF-hand 1

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000398763

408_443

113.0

279.0

Domain

EF-hand 2

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000418483

218_253

113.0

279.0

Domain

EF-hand 1

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000418483

408_443

113.0

279.0

Domain

EF-hand 2

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000361114

408_443

311.0

477.0

Domain

EF-hand 2

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000398763

218_253

113.0

279.0

Domain

EF-hand 1

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000398763

408_443

113.0

279.0

Domain

EF-hand 2

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000418483

218_253

113.0

279.0

Domain

EF-hand 1

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000418483

408_443

113.0

279.0

Domain

EF-hand 2

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000361114

455_465

393.3333333333333

477.0

Region

C-helix region

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000398763

455_465

195.33333333333334

279.0

Region

C-helix region

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000418483

455_465

195.33333333333334

279.0

Region

C-helix region

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000361114

455_465

393.3333333333333

477.0

Region

C-helix region

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000398763

455_465

195.33333333333334

279.0

Region

C-helix region

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000418483

455_465

195.33333333333334

279.0

Region

C-helix region

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000361114

455_465

393.3333333333333

477.0

Region

C-helix region

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000398763

455_465

195.33333333333334

279.0

Region

C-helix region

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000418483

455_465

195.33333333333334

279.0

Region

C-helix region

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000361114

455_465

357.0

477.0

Region

C-helix region

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000398763

455_465

159.0

279.0

Region

C-helix region

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000418483

455_465

159.0

279.0

Region

C-helix region

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000361114

455_465

311.0

477.0

Region

C-helix region

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000398763

455_465

113.0

279.0

Region

C-helix region

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000418483

455_465

113.0

279.0

Region

C-helix region

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000361114

455_465

311.0

477.0

Region

C-helix region

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000398763

455_465

113.0

279.0

Region

C-helix region

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000418483

455_465

113.0

279.0

Region

C-helix region

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ASCC1

chr10:73972945

chr10:74183129

ENST00000317126

86_148

37.333333333333336

358.0

Domain

Hgene

ASCC1

chr10:73972945

chr10:74183129

ENST00000317168

86_148

37.333333333333336

358.0

Domain

Hgene

ASCC1

chr10:73972945

chr10:74183129

ENST00000342444

86_148

37.333333333333336

666.0

Domain

Hgene

ASCC1

chr10:73972945

chr10:74183129

ENST00000394915

86_148

37.333333333333336

401.0

Domain

Hgene

ASCC1

chr10:73972945

chr10:74183129

ENST00000394919

86_148

37.333333333333336

358.0

Domain

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000361114

231_242

393.3333333333333

477.0

Calcium binding

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000361114

231_242

393.3333333333333

477.0

Calcium binding

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000361114

231_242

393.3333333333333

477.0

Calcium binding

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000361114

231_242

357.0

477.0

Calcium binding

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000361114

231_242

311.0

477.0

Calcium binding

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000361114

231_242

311.0

477.0

Calcium binding

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000361114

218_253

393.3333333333333

477.0

Domain

EF-hand 1

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000361114

218_253

393.3333333333333

477.0

Domain

EF-hand 1

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000361114

218_253

393.3333333333333

477.0

Domain

EF-hand 1

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000361114

218_253

357.0

477.0

Domain

EF-hand 1

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000361114

218_253

311.0

477.0

Domain

EF-hand 1

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000361114

218_253

311.0

477.0

Domain

EF-hand 1

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000361114

99_110

393.3333333333333

477.0

Region

Polybasic region

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000398763

99_110

195.33333333333334

279.0

Region

Polybasic region

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000418483

99_110

195.33333333333334

279.0

Region

Polybasic region

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000361114

99_110

393.3333333333333

477.0

Region

Polybasic region

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000398763

99_110

195.33333333333334

279.0

Region

Polybasic region

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000418483

99_110

195.33333333333334

279.0

Region

Polybasic region

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000361114

99_110

393.3333333333333

477.0

Region

Polybasic region

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000398763

99_110

195.33333333333334

279.0

Region

Polybasic region

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000418483

99_110

195.33333333333334

279.0

Region

Polybasic region

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000361114

99_110

357.0

477.0

Region

Polybasic region

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000398763

99_110

159.0

279.0

Region

Polybasic region

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000418483

99_110

159.0

279.0

Region

Polybasic region

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000361114

99_110

311.0

477.0

Region

Polybasic region

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000398763

99_110

113.0

279.0

Region

Polybasic region

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000418483

99_110

113.0

279.0

Region

Polybasic region

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000361114

99_110

311.0

477.0

Region

Polybasic region

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000398763

99_110

113.0

279.0

Region

Polybasic region

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000418483

99_110

113.0

279.0

Region

Polybasic region

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000361114

53_476

393.3333333333333

477.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000398763

53_476

195.33333333333334

279.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000418483

53_476

195.33333333333334

279.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000361114

53_476

393.3333333333333

477.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000398763

53_476

195.33333333333334

279.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000418483

53_476

195.33333333333334

279.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000361114

53_476

393.3333333333333

477.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000398763

53_476

195.33333333333334

279.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000418483

53_476

195.33333333333334

279.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000361114

53_476

357.0

477.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000398763

53_476

159.0

279.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000418483

53_476

159.0

279.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000361114

53_476

311.0

477.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000398763

53_476

113.0

279.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000418483

53_476

113.0

279.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000361114

53_476

311.0

477.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000398763

53_476

113.0

279.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000418483

53_476

113.0

279.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000361114

34_52

393.3333333333333

477.0

Transmembrane

Helical

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000398763

34_52

195.33333333333334

279.0

Transmembrane

Helical

Tgene

MICU1

chr10:73892815

chr10:74135630

ENST00000418483

34_52

195.33333333333334

279.0

Transmembrane

Helical

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000361114

34_52

393.3333333333333

477.0

Transmembrane

Helical

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000398763

34_52

195.33333333333334

279.0

Transmembrane

Helical

Tgene

MICU1

chr10:73956568

chr10:74135630

ENST00000418483

34_52

195.33333333333334

279.0

Transmembrane

Helical

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000361114

34_52

393.3333333333333

477.0

Transmembrane

Helical

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000398763

34_52

195.33333333333334

279.0

Transmembrane

Helical

Tgene

MICU1

chr10:73956569

chr10:74135630

ENST00000418483

34_52

195.33333333333334

279.0

Transmembrane

Helical

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000361114

34_52

357.0

477.0

Transmembrane

Helical

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000398763

34_52

159.0

279.0

Transmembrane

Helical

Tgene

MICU1

chr10:73956569

chr10:74167795

ENST00000418483

34_52

159.0

279.0

Transmembrane

Helical

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000361114

34_52

311.0

477.0

Transmembrane

Helical

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000398763

34_52

113.0

279.0

Transmembrane

Helical

Tgene

MICU1

chr10:73956569

chr10:74183129

ENST00000418483

34_52

113.0

279.0

Transmembrane

Helical

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000361114

34_52

311.0

477.0

Transmembrane

Helical

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000398763

34_52

113.0

279.0

Transmembrane

Helical

Tgene

MICU1

chr10:73972945

chr10:74183129

ENST00000418483

34_52

113.0

279.0

Transmembrane

Helical

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>252_ASCC1_73956569_MICU1_74135630_ranked_0.pdb	ASCC1	73956568	73956569	ENST00000398763	MICU1	chr10	74135630	-	MGGAVEADKCLSFTDLFMFLRTYGDTHWAESEPSRTRGRGRVKRGNRQSPEVIPGGRGTTSRSSSTKGSAETLRRGSRVLGVEGSPLAVW GYCLGKAKSQAVSCAHFHMACMRRVKPMSLGFSRPLISRCFMMETNSLLLSSPLPSQSKSANTTSHTWSESSTLATVLATCCMVTWSTSP	196

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

ASCC1_pLDDT.png

MICU1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ASCC1
MICU1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to ASCC1-MICU1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ASCC1-MICU1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source