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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PTPRC-STAG1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PTPRC-STAG1
	FusionPDB ID: 70335
	FusionGDB2.0 ID: 70335
		Hgene	Tgene
	Gene symbol	PTPRC	STAG1
	Gene ID	5788	56937
	Gene name	protein tyrosine phosphatase receptor type C	prostate transmembrane protein, androgen induced 1
	Synonyms	B220\|CD45\|CD45R\|GP180\|L-CA\|LCA\|LY5\|T200	STAG1\|TMEPAI
	Cytomap	1q31.3-q32.1	20q13.31
	Type of gene	protein-coding	protein-coding
	Description	receptor-type tyrosine-protein phosphatase CCD45 antigenT200 glycoproteinT200 leukocyte common antigenprotein tyrosine phosphatase, receptor type, c polypeptide	protein TMEPAIsolid tumor-associated 1 proteintransmembrane, prostate androgen induced RNA
	Modification date	20200327	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000391970, ENST00000348564, ENST00000352140, ENST00000367364, ENST00000367376, ENST00000413409, ENST00000442510, ENST00000594404, ENST00000598951,	ENST00000236698, ENST00000383202, ENST00000434713, ENST00000480733, ENST00000536929,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 6 X 3=108	16 X 17 X 8=2176
	# samples	6	23
	** MAII score	log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(23/2176*10)=-3.24197279030596 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PTPRC [Title/Abstract] AND STAG1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PTPRC(198661502)-STAG1(136096594), # samples:2
Anticipated loss of major functional domain due to fusion event.	PTPRC-STAG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PTPRC-STAG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PTPRC-STAG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PTPRC-STAG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PTPRC-STAG1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. PTPRC-STAG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PTPRC-STAG1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PTPRC-STAG1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. PTPRC-STAG1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. PTPRC-STAG1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PTPRC	GO:0006469	negative regulation of protein kinase activity	9197241
Hgene	PTPRC	GO:0032677	regulation of interleukin-8 production	12100025
Hgene	PTPRC	GO:0050764	regulation of phagocytosis	12100025
Hgene	PTPRC	GO:0050852	T cell receptor signaling pathway	10358156
Hgene	PTPRC	GO:0061097	regulation of protein tyrosine kinase activity	12100025
Tgene	STAG1	GO:0010991	negative regulation of SMAD protein complex assembly	20129061
Tgene	STAG1	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	24627487
Tgene	STAG1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	24627487

Fusion gene breakpoints across PTPRC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across STAG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8284-01A	PTPRC	chr1	198661502	+	STAG1	chr3	136096594	-
ChimerDB4	STAD	TCGA-BR-8284	PTPRC	chr1	198661502	+	STAG1	chr3	136096594	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000598951	PTPRC	chr1	198661502	+	ENST00000383202	STAG1	chr3	136096594	-	4590	1071	1077	2570	497
ENST00000598951	PTPRC	chr1	198661502	+	ENST00000236698	STAG1	chr3	136096594	-	4478	1071	1077	2459	460
ENST00000598951	PTPRC	chr1	198661502	+	ENST00000434713	STAG1	chr3	136096594	-	3333	1071	1077	2468	463
ENST00000367364	PTPRC	chr1	198661502	+	ENST00000383202	STAG1	chr3	136096594	-	4509	990	996	2489	497
ENST00000367364	PTPRC	chr1	198661502	+	ENST00000236698	STAG1	chr3	136096594	-	4397	990	996	2378	460
ENST00000367364	PTPRC	chr1	198661502	+	ENST00000434713	STAG1	chr3	136096594	-	3252	990	996	2387	463

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000598951	ENST00000383202	PTPRC	chr1	198661502	+	STAG1	chr3	136096594	-	0.000116162	0.9998838
ENST00000598951	ENST00000236698	PTPRC	chr1	198661502	+	STAG1	chr3	136096594	-	0.000106047	0.9998939
ENST00000598951	ENST00000434713	PTPRC	chr1	198661502	+	STAG1	chr3	136096594	-	0.000130383	0.9998696
ENST00000367364	ENST00000383202	PTPRC	chr1	198661502	+	STAG1	chr3	136096594	-	0.000112789	0.9998872
ENST00000367364	ENST00000236698	PTPRC	chr1	198661502	+	STAG1	chr3	136096594	-	0.000103739	0.9998963
ENST00000367364	ENST00000434713	PTPRC	chr1	198661502	+	STAG1	chr3	136096594	-	0.000126793	0.99987316

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>70335_70335_1_PTPRC-STAG1_PTPRC_chr1_198661502_ENST00000367364_STAG1_chr3_136096594_ENST00000236698_length(amino acids)=460AA_BP=
MLVLRKTVKSFLAVCQQCLSNVNTPVKEQAFMLLCDLLMIFSHQLMTGGREGLQPLVFNPDTGLQSELLSFVMDHVFIDQDEENQSMEGD
EEDEANKIEALHKRRNLLAAFSKLIIYDIVDMHAAADIFKHYMKYYNDYGDIIKETLSKTRQIDKIQCAKTLILSLQQLFNELVQEQGPN
LDRTSAHVSGIKELARRFALTFGLDQIKTREAVATLHKDGIEFAFKYQNQKGQEYPPPNLAFLEVLSEFSSKLLRQDKKTVHSYLEKFLT
EQMMERREDVWLPLISYRNSLVTGGEDDRMSVNSGSSSSKTSSVRNKKGRPPLHKKRVEDESLDNTWLNRTDTMIQTPGPLPAPQLTSTV
LRENSRPMGDQIQEPESEHGSEPDFLHNRGLMEEDAEPIFEDVMMSSRSQLEDMNEEFEDTMVIDLPPSRNRRERAELRPDFFDSAAIIE

--------------------------------------------------------------

>70335_70335_2_PTPRC-STAG1_PTPRC_chr1_198661502_ENST00000367364_STAG1_chr3_136096594_ENST00000383202_length(amino acids)=497AA_BP=
MLVLRKTVKSFLAVCQQCLSNVNTPVKEQAFMLLCDLLMIFSHQLMTGGREGLQPLVFNPDTGLQSELLSFVMDHVFIDQDEENQSMEGD
EEDEANKIEALHKRRNLLAAFSKLIIYDIVDMHAAADIFKHYMKYYNDYGDIIKETLSKTRQIDKIQCAKTLILSLQQLFNELVQEQGPN
LDRTSAHVSGIKELARRFALTFGLDQIKTREAVATLHKDGIEFAFKYQNQKGQEYPPPNLAFLEVLSEFSSKLLRQDKKTVHSYLEKFLT
EQMMERREDVWLPLISYRNSLVTGGEDDRMSVNSGSSSSKTSSVRNKKGRPPLHKKRVEDESLDNTWLNRTDTMIQTPGPLPAPQLTSTV
LRENSRPMGDQIQEPESEHGSEPDFLHNPQMQISWLGQPKLEDLNRKDRTGMNYMKVRTGVRHAVRGLMEEDAEPIFEDVMMSSRSQLED

--------------------------------------------------------------

>70335_70335_3_PTPRC-STAG1_PTPRC_chr1_198661502_ENST00000367364_STAG1_chr3_136096594_ENST00000434713_length(amino acids)=463AA_BP=
MLVLRKTVKSFLAVCQQCLSNVNTPVKEQAFMLLCDLLMIFSHQLMTGGREGLQPLVFNPDTGLQSELLSFVMDHVFIDQDEENQSMEGD
EEDEANKIEALHKRRNLLAAFSKLIIYDIVDMHAAADIFKHYMKLFNELVQEQGPNLDRTSAHVSGIKELARRFALTFGLDQIKTREAVA
TLHKDGIEFAFKYQNQKGQEYPPPNLAFLEVLSEFSSKLLRQDKKTVHSYLEKFLTEQMMERREDVWLPLISYRNSLVTGGEDDRMSVNS
GSSSSKTSSVRNKKGRPPLHKKRVEDESLDNTWLNRTDTMIQTPGPLPAPQLTSTVLRENSRPMGDQIQEPESEHGSEPDFLHNPQMQIS
WLGQPKLEDLNRKDRTGMNYMKVRTGVRHAVRGLMEEDAEPIFEDVMMSSRSQLEDMNEEFEDTMVIDLPPSRNRRERAELRPDFFDSAA

--------------------------------------------------------------

>70335_70335_4_PTPRC-STAG1_PTPRC_chr1_198661502_ENST00000598951_STAG1_chr3_136096594_ENST00000236698_length(amino acids)=460AA_BP=
MLVLRKTVKSFLAVCQQCLSNVNTPVKEQAFMLLCDLLMIFSHQLMTGGREGLQPLVFNPDTGLQSELLSFVMDHVFIDQDEENQSMEGD
EEDEANKIEALHKRRNLLAAFSKLIIYDIVDMHAAADIFKHYMKYYNDYGDIIKETLSKTRQIDKIQCAKTLILSLQQLFNELVQEQGPN
LDRTSAHVSGIKELARRFALTFGLDQIKTREAVATLHKDGIEFAFKYQNQKGQEYPPPNLAFLEVLSEFSSKLLRQDKKTVHSYLEKFLT
EQMMERREDVWLPLISYRNSLVTGGEDDRMSVNSGSSSSKTSSVRNKKGRPPLHKKRVEDESLDNTWLNRTDTMIQTPGPLPAPQLTSTV
LRENSRPMGDQIQEPESEHGSEPDFLHNRGLMEEDAEPIFEDVMMSSRSQLEDMNEEFEDTMVIDLPPSRNRRERAELRPDFFDSAAIIE

--------------------------------------------------------------

>70335_70335_5_PTPRC-STAG1_PTPRC_chr1_198661502_ENST00000598951_STAG1_chr3_136096594_ENST00000383202_length(amino acids)=497AA_BP=
MLVLRKTVKSFLAVCQQCLSNVNTPVKEQAFMLLCDLLMIFSHQLMTGGREGLQPLVFNPDTGLQSELLSFVMDHVFIDQDEENQSMEGD
EEDEANKIEALHKRRNLLAAFSKLIIYDIVDMHAAADIFKHYMKYYNDYGDIIKETLSKTRQIDKIQCAKTLILSLQQLFNELVQEQGPN
LDRTSAHVSGIKELARRFALTFGLDQIKTREAVATLHKDGIEFAFKYQNQKGQEYPPPNLAFLEVLSEFSSKLLRQDKKTVHSYLEKFLT
EQMMERREDVWLPLISYRNSLVTGGEDDRMSVNSGSSSSKTSSVRNKKGRPPLHKKRVEDESLDNTWLNRTDTMIQTPGPLPAPQLTSTV
LRENSRPMGDQIQEPESEHGSEPDFLHNPQMQISWLGQPKLEDLNRKDRTGMNYMKVRTGVRHAVRGLMEEDAEPIFEDVMMSSRSQLED

--------------------------------------------------------------

>70335_70335_6_PTPRC-STAG1_PTPRC_chr1_198661502_ENST00000598951_STAG1_chr3_136096594_ENST00000434713_length(amino acids)=463AA_BP=
MLVLRKTVKSFLAVCQQCLSNVNTPVKEQAFMLLCDLLMIFSHQLMTGGREGLQPLVFNPDTGLQSELLSFVMDHVFIDQDEENQSMEGD
EEDEANKIEALHKRRNLLAAFSKLIIYDIVDMHAAADIFKHYMKLFNELVQEQGPNLDRTSAHVSGIKELARRFALTFGLDQIKTREAVA
TLHKDGIEFAFKYQNQKGQEYPPPNLAFLEVLSEFSSKLLRQDKKTVHSYLEKFLTEQMMERREDVWLPLISYRNSLVTGGEDDRMSVNS
GSSSSKTSSVRNKKGRPPLHKKRVEDESLDNTWLNRTDTMIQTPGPLPAPQLTSTVLRENSRPMGDQIQEPESEHGSEPDFLHNPQMQIS
WLGQPKLEDLNRKDRTGMNYMKVRTGVRHAVRGLMEEDAEPIFEDVMMSSRSQLEDMNEEFEDTMVIDLPPSRNRRERAELRPDFFDSAA

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:198661502/chr3:136096594)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

STAG1

chr1:198661502

chr3:136096594

ENST00000383202

1065_1070

759.0

1259.0

Compositional bias

Note=Poly-Ser

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PTPRC

chr1:198661502

chr3:136096594

ENST00000367376

391_483

31.333333333333332

1305.0

Domain

Fibronectin type-III 1

Hgene

PTPRC

chr1:198661502

chr3:136096594

ENST00000367376

484_576

31.333333333333332

1305.0

Domain

Fibronectin type-III 2

Hgene

PTPRC

chr1:198661502

chr3:136096594

ENST00000367376

653_912

31.333333333333332

1305.0

Domain

Tyrosine-protein phosphatase 1

Hgene

PTPRC

chr1:198661502

chr3:136096594

ENST00000367376

944_1228

31.333333333333332

1305.0

Domain

Tyrosine-protein phosphatase 2

Hgene

PTPRC

chr1:198661502

chr3:136096594

ENST00000594404

391_483

31.333333333333332

1144.0

Domain

Fibronectin type-III 1

Hgene

PTPRC

chr1:198661502

chr3:136096594

ENST00000594404

484_576

31.333333333333332

1144.0

Domain

Fibronectin type-III 2

Hgene

PTPRC

chr1:198661502

chr3:136096594

ENST00000594404

653_912

31.333333333333332

1144.0

Domain

Tyrosine-protein phosphatase 1

Hgene

PTPRC

chr1:198661502

chr3:136096594

ENST00000594404

944_1228

31.333333333333332

1144.0

Domain

Tyrosine-protein phosphatase 2

Hgene

PTPRC

chr1:198661502

chr3:136096594

ENST00000367376

853_859

31.333333333333332

1305.0

Region

Substrate binding

Hgene

PTPRC

chr1:198661502

chr3:136096594

ENST00000594404

853_859

31.333333333333332

1144.0

Region

Substrate binding

Hgene

PTPRC

chr1:198661502

chr3:136096594

ENST00000367376

26_577

31.333333333333332

1305.0

Topological domain

Extracellular

Hgene

PTPRC

chr1:198661502

chr3:136096594

ENST00000367376

599_1306

31.333333333333332

1305.0

Topological domain

Cytoplasmic

Hgene

PTPRC

chr1:198661502

chr3:136096594

ENST00000594404

26_577

31.333333333333332

1144.0

Topological domain

Extracellular

Hgene

PTPRC

chr1:198661502

chr3:136096594

ENST00000594404

599_1306

31.333333333333332

1144.0

Topological domain

Cytoplasmic

Hgene

PTPRC

chr1:198661502

chr3:136096594

ENST00000367376

578_598

31.333333333333332

1305.0

Transmembrane

Helical

Hgene

PTPRC

chr1:198661502

chr3:136096594

ENST00000594404

578_598

31.333333333333332

1144.0

Transmembrane

Helical

Tgene

STAG1

chr1:198661502

chr3:136096594

ENST00000383202

684_687

759.0

1259.0

Compositional bias

Note=Poly-Asp

Tgene

STAG1

chr1:198661502

chr3:136096594

ENST00000383202

296_381

759.0

1259.0

Domain

SCD

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1056_PTPRC_198661502_STAG1_136096594_1056_PTPRC_198661502_STAG1_136096594_ranked_0.pdb	PTPRC	198661502	198661502	ENST00000434713	STAG1	chr3	136096594	-	MLVLRKTVKSFLAVCQQCLSNVNTPVKEQAFMLLCDLLMIFSHQLMTGGREGLQPLVFNPDTGLQSELLSFVMDHVFIDQDEENQSMEGD EEDEANKIEALHKRRNLLAAFSKLIIYDIVDMHAAADIFKHYMKYYNDYGDIIKETLSKTRQIDKIQCAKTLILSLQQLFNELVQEQGPN LDRTSAHVSGIKELARRFALTFGLDQIKTREAVATLHKDGIEFAFKYQNQKGQEYPPPNLAFLEVLSEFSSKLLRQDKKTVHSYLEKFLT EQMMERREDVWLPLISYRNSLVTGGEDDRMSVNSGSSSSKTSSVRNKKGRPPLHKKRVEDESLDNTWLNRTDTMIQTPGPLPAPQLTSTV LRENSRPMGDQIQEPESEHGSEPDFLHNPQMQISWLGQPKLEDLNRKDRTGMNYMKVRTGVRHAVRGLMEEDAEPIFEDVMMSSRSQLED	497

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

PTPRC_pLDDT.png

STAG1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PTPRC
STAG1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to PTPRC-STAG1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to PTPRC-STAG1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source