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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PTPRD-TRHDE

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PTPRD-TRHDE
FusionPDB ID: 70364
FusionGDB2.0 ID: 70364
HgeneTgene
Gene symbol

PTPRD

TRHDE

Gene ID

5789

29953

Gene nameprotein tyrosine phosphatase receptor type Dthyrotropin releasing hormone degrading enzyme
SynonymsHPTP|HPTPD|HPTPDELTA|PTPD|R-PTP-delta|RPTPDELTAPAP-II|PGPEP2|TRH-DE
Cytomap

9p24.1-p23

12q21.1

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase deltaprotein tyrosine phosphatase, receptor type, delta polypeptiderceptor-type tyrosine-protein phosphatase deltathyrotropin-releasing hormone-degrading ectoenzymeTRH-degrading ectoenzymeTRH-specific aminopeptidasepyroglutamyl aminopeptidase IIpyroglutamyl-peptidase IIthyroliberinase
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000355233, ENST00000356435, 
ENST00000358503, ENST00000360074, 
ENST00000381196, ENST00000397611, 
ENST00000397617, ENST00000537002, 
ENST00000397606, ENST00000463477, 
ENST00000471274, ENST00000486161, 
ENST00000540109, 		ENST00000549138, 
ENST00000261180, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score26 X 25 X 7=455019 X 12 X 7=1596
# samples 2821
** MAII scorelog2(28/4550*10)=-4.02236781302845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/1596*10)=-2.92599941855622
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PTPRD [Title/Abstract] AND TRHDE [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PTPRD(8857638)-TRHDE(72893278), # samples:1
PTPRD(8314247)-TRHDE(72666463), # samples:1
Anticipated loss of major functional domain due to fusion event.PTPRD-TRHDE seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPRD-TRHDE seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPRD-TRHDE seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPRD-TRHDE seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPRD

GO:0099545

trans-synaptic signaling by trans-synaptic complex

21926414

HgenePTPRD

GO:0099560

synaptic membrane adhesion

23345436

HgenePTPRD

GO:1905606

regulation of presynapse assembly

21926414


check buttonFusion gene breakpoints across PTPRD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TRHDE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-IF-A3RQ-01APTPRDchr9

8314247

-TRHDEchr12

72666463

+
ChimerDB4SARCTCGA-IF-A3RQ-01APTPRDchr9

8857638

-TRHDEchr12

72893278

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000381196PTPRDchr98314247-ENST00000261180TRHDEchr1272666463+15529991152662821918
ENST00000360074PTPRDchr98314247-ENST00000261180TRHDEchr1272666463+1504894308558021905
ENST00000537002PTPRDchr98314247-ENST00000261180TRHDEchr1272666463+1385782398546111508
ENST00000397617PTPRDchr98314247-ENST00000261180TRHDEchr1272666463+1386682488546201511
ENST00000358503PTPRDchr98314247-ENST00000261180TRHDEchr1272666463+1502194038557751896
ENST00000397611PTPRDchr98314247-ENST00000261180TRHDEchr1272666463+1385782398546111508
ENST00000355233PTPRDchr98314247-ENST00000261180TRHDEchr1272666463+1386982518546231512
ENST00000356435PTPRDchr98314247-ENST00000261180TRHDEchr1272666463+1509094728858441918

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000381196ENST00000261180PTPRDchr98314247-TRHDEchr1272666463+0.0002899670.99971
ENST00000360074ENST00000261180PTPRDchr98314247-TRHDEchr1272666463+0.0001771630.9998229
ENST00000537002ENST00000261180PTPRDchr98314247-TRHDEchr1272666463+4.37E-050.99995625
ENST00000397617ENST00000261180PTPRDchr98314247-TRHDEchr1272666463+7.52E-050.9999248
ENST00000358503ENST00000261180PTPRDchr98314247-TRHDEchr1272666463+0.0001765770.9998235
ENST00000397611ENST00000261180PTPRDchr98314247-TRHDEchr1272666463+4.37E-050.99995637
ENST00000355233ENST00000261180PTPRDchr98314247-TRHDEchr1272666463+6.83E-050.9999317
ENST00000356435ENST00000261180PTPRDchr98314247-TRHDEchr1272666463+0.0001782770.9998217

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>70364_70364_1_PTPRD-TRHDE_PTPRD_chr9_8314247_ENST00000355233_TRHDE_chr12_72666463_ENST00000261180_length(amino acids)=1512AA_BP=
MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI
QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR
IKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPM
PYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYY
IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEP
NGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILL
SWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVL
LSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMIT
VQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFT
NKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSSKPDRKRAESDSR
KSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVI
AYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLV
QVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAML
ERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSR
FISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMG
REKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI

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>70364_70364_2_PTPRD-TRHDE_PTPRD_chr9_8314247_ENST00000356435_TRHDE_chr12_72666463_ENST00000261180_length(amino acids)=1918AA_BP=
MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI
QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR
IKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPM
PYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYY
IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEP
NGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILL
SWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSST
SILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP
PRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYT
TKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFR
LSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGL
KPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVN
LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEM
ELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMD
LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELAD
HIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPE
TFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGV
PEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVT
CGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASF
IDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD
GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRP

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>70364_70364_3_PTPRD-TRHDE_PTPRD_chr9_8314247_ENST00000358503_TRHDE_chr12_72666463_ENST00000261180_length(amino acids)=1896AA_BP=
MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI
QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR
IKQLRSGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLT
PEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELY
KEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTM
DPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY
ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEK
QNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTS
VKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK
PRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEE
VPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYS
PSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQ
HRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREV
ELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLA
VVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDP
GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTK
LEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDA
GPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIE
TGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTE
DFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKS
GEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS

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>70364_70364_4_PTPRD-TRHDE_PTPRD_chr9_8314247_ENST00000360074_TRHDE_chr12_72666463_ENST00000261180_length(amino acids)=1905AA_BP=
MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI
QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR
IKQLRSGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLT
PEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELY
KEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTM
DPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY
ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEK
QNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTS
VKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLV
STTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEM
VKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAH
TSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTN
RGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKR
RSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGL
IWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKF
SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQR
SATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRR
VKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYA
YIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIAT
QGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTD
WPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY

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>70364_70364_5_PTPRD-TRHDE_PTPRD_chr9_8314247_ENST00000381196_TRHDE_chr12_72666463_ENST00000261180_length(amino acids)=1918AA_BP=
MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI
QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR
IKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPM
PYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYY
IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEP
NGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILL
SWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSST
SILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP
PRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYT
TKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFR
LSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGL
KPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVN
LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEM
ELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMD
LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELAD
HIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPE
TFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGV
PEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVT
CGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASF
IDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD
GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRP

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>70364_70364_6_PTPRD-TRHDE_PTPRD_chr9_8314247_ENST00000397611_TRHDE_chr12_72666463_ENST00000261180_length(amino acids)=1508AA_BP=
MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI
QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR
IKQLRSGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYV
KWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQ
HKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQ
IQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWT
PPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVLLSW
EIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQL
PEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQ
LQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSI
PNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDH
SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTL
LDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIK
HEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISA
NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKC
HQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC

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>70364_70364_7_PTPRD-TRHDE_PTPRD_chr9_8314247_ENST00000397617_TRHDE_chr12_72666463_ENST00000261180_length(amino acids)=1511AA_BP=
MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI
QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR
IKQLRSVSIGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAE
DLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSE
ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVY
YTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTI
ANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYN
SAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANE
NIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY
VFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHP
TDPVELRRLNFQTPGSDDSGYPGNLHSSSMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIA
YDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQ
VTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE
RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRF
ISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGR
EKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS

--------------------------------------------------------------

>70364_70364_8_PTPRD-TRHDE_PTPRD_chr9_8314247_ENST00000537002_TRHDE_chr12_72666463_ENST00000261180_length(amino acids)=1508AA_BP=
MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI
QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR
IKQLRSGRVFHTGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVNRKVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYV
KWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQ
HKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQ
IQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWT
PPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVLLSW
EIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQL
PEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQ
LQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKPYRKRAESDSRKSSI
PNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDH
SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTL
LDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIK
HEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISA
NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKC
HQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:8857638/chr12:72893278)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRDchr9:8314247chr12:72666463ENST00000355233-31311020_11062716.01507.0DomainFibronectin type-III 8
HgenePTPRDchr9:8314247chr12:72666463ENST00000355233-3131126_2242716.01507.0DomainNote=Ig-like C2-type 2
HgenePTPRDchr9:8314247chr12:72666463ENST00000355233-31311357_16122716.01507.0DomainTyrosine-protein phosphatase 1
HgenePTPRDchr9:8314247chr12:72666463ENST00000355233-31311644_19032716.01507.0DomainTyrosine-protein phosphatase 2
HgenePTPRDchr9:8314247chr12:72666463ENST00000355233-3131236_3182716.01507.0DomainNote=Ig-like C2-type 3
HgenePTPRDchr9:8314247chr12:72666463ENST00000355233-313124_1142716.01507.0DomainNote=Ig-like C2-type 1
HgenePTPRDchr9:8314247chr12:72666463ENST00000355233-3131325_4152716.01507.0DomainFibronectin type-III 1
HgenePTPRDchr9:8314247chr12:72666463ENST00000355233-3131420_5162716.01507.0DomainFibronectin type-III 2
HgenePTPRDchr9:8314247chr12:72666463ENST00000355233-3131518_6072716.01507.0DomainFibronectin type-III 3
HgenePTPRDchr9:8314247chr12:72666463ENST00000355233-3131612_7092716.01507.0DomainFibronectin type-III 4
HgenePTPRDchr9:8314247chr12:72666463ENST00000355233-3131714_8222716.01507.0DomainFibronectin type-III 5
HgenePTPRDchr9:8314247chr12:72666463ENST00000355233-3131823_9162716.01507.0DomainFibronectin type-III 6
HgenePTPRDchr9:8314247chr12:72666463ENST00000355233-3131921_10162716.01507.0DomainFibronectin type-III 7
HgenePTPRDchr9:8314247chr12:72666463ENST00000356435-35351020_11063122.01913.0DomainFibronectin type-III 8
HgenePTPRDchr9:8314247chr12:72666463ENST00000356435-3535126_2243122.01913.0DomainNote=Ig-like C2-type 2
HgenePTPRDchr9:8314247chr12:72666463ENST00000356435-35351357_16123122.01913.0DomainTyrosine-protein phosphatase 1
HgenePTPRDchr9:8314247chr12:72666463ENST00000356435-35351644_19033122.01913.0DomainTyrosine-protein phosphatase 2
HgenePTPRDchr9:8314247chr12:72666463ENST00000356435-3535236_3183122.01913.0DomainNote=Ig-like C2-type 3
HgenePTPRDchr9:8314247chr12:72666463ENST00000356435-353524_1143122.01913.0DomainNote=Ig-like C2-type 1
HgenePTPRDchr9:8314247chr12:72666463ENST00000356435-3535325_4153122.01913.0DomainFibronectin type-III 1
HgenePTPRDchr9:8314247chr12:72666463ENST00000356435-3535420_5163122.01913.0DomainFibronectin type-III 2
HgenePTPRDchr9:8314247chr12:72666463ENST00000356435-3535518_6073122.01913.0DomainFibronectin type-III 3
HgenePTPRDchr9:8314247chr12:72666463ENST00000356435-3535612_7093122.01913.0DomainFibronectin type-III 4
HgenePTPRDchr9:8314247chr12:72666463ENST00000356435-3535714_8223122.01913.0DomainFibronectin type-III 5
HgenePTPRDchr9:8314247chr12:72666463ENST00000356435-3535823_9163122.01913.0DomainFibronectin type-III 6
HgenePTPRDchr9:8314247chr12:72666463ENST00000356435-3535921_10163122.01913.0DomainFibronectin type-III 7
HgenePTPRDchr9:8314247chr12:72666463ENST00000381196-43431020_11063122.33333333333351913.0DomainFibronectin type-III 8
HgenePTPRDchr9:8314247chr12:72666463ENST00000381196-4343126_2243122.33333333333351913.0DomainNote=Ig-like C2-type 2
HgenePTPRDchr9:8314247chr12:72666463ENST00000381196-43431357_16123122.33333333333351913.0DomainTyrosine-protein phosphatase 1
HgenePTPRDchr9:8314247chr12:72666463ENST00000381196-43431644_19033122.33333333333351913.0DomainTyrosine-protein phosphatase 2
HgenePTPRDchr9:8314247chr12:72666463ENST00000381196-4343236_3183122.33333333333351913.0DomainNote=Ig-like C2-type 3
HgenePTPRDchr9:8314247chr12:72666463ENST00000381196-434324_1143122.33333333333351913.0DomainNote=Ig-like C2-type 1
HgenePTPRDchr9:8314247chr12:72666463ENST00000381196-4343325_4153122.33333333333351913.0DomainFibronectin type-III 1
HgenePTPRDchr9:8314247chr12:72666463ENST00000381196-4343420_5163122.33333333333351913.0DomainFibronectin type-III 2
HgenePTPRDchr9:8314247chr12:72666463ENST00000381196-4343518_6073122.33333333333351913.0DomainFibronectin type-III 3
HgenePTPRDchr9:8314247chr12:72666463ENST00000381196-4343612_7093122.33333333333351913.0DomainFibronectin type-III 4
HgenePTPRDchr9:8314247chr12:72666463ENST00000381196-4343714_8223122.33333333333351913.0DomainFibronectin type-III 5
HgenePTPRDchr9:8314247chr12:72666463ENST00000381196-4343823_9163122.33333333333351913.0DomainFibronectin type-III 6
HgenePTPRDchr9:8314247chr12:72666463ENST00000381196-4343921_10163122.33333333333351913.0DomainFibronectin type-III 7
HgenePTPRDchr9:8314247chr12:72666463ENST00000355233-31311553_15592716.01507.0RegionSubstrate binding
HgenePTPRDchr9:8314247chr12:72666463ENST00000356435-35351553_15593122.01913.0RegionSubstrate binding
HgenePTPRDchr9:8314247chr12:72666463ENST00000381196-43431553_15593122.33333333333351913.0RegionSubstrate binding
HgenePTPRDchr9:8314247chr12:72666463ENST00000355233-31311291_19122716.01507.0Topological domainCytoplasmic
HgenePTPRDchr9:8314247chr12:72666463ENST00000355233-313121_12652716.01507.0Topological domainExtracellular
HgenePTPRDchr9:8314247chr12:72666463ENST00000356435-35351291_19123122.01913.0Topological domainCytoplasmic
HgenePTPRDchr9:8314247chr12:72666463ENST00000356435-353521_12653122.01913.0Topological domainExtracellular
HgenePTPRDchr9:8314247chr12:72666463ENST00000381196-43431291_19123122.33333333333351913.0Topological domainCytoplasmic
HgenePTPRDchr9:8314247chr12:72666463ENST00000381196-434321_12653122.33333333333351913.0Topological domainExtracellular
HgenePTPRDchr9:8314247chr12:72666463ENST00000355233-31311266_12902716.01507.0TransmembraneHelical
HgenePTPRDchr9:8314247chr12:72666463ENST00000356435-35351266_12903122.01913.0TransmembraneHelical
HgenePTPRDchr9:8314247chr12:72666463ENST00000381196-43431266_12903122.33333333333351913.0TransmembraneHelical
TgeneTRHDEchr9:8314247chr12:72666463ENST00000261180-119404_408259.66666666666671025.0RegionSubstrate binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRDchr9:8314247chr12:72666463ENST00000397606-1291020_110601506.0DomainFibronectin type-III 8
HgenePTPRDchr9:8314247chr12:72666463ENST00000397606-129126_22401506.0DomainNote=Ig-like C2-type 2
HgenePTPRDchr9:8314247chr12:72666463ENST00000397606-1291357_161201506.0DomainTyrosine-protein phosphatase 1
HgenePTPRDchr9:8314247chr12:72666463ENST00000397606-1291644_190301506.0DomainTyrosine-protein phosphatase 2
HgenePTPRDchr9:8314247chr12:72666463ENST00000397606-129236_31801506.0DomainNote=Ig-like C2-type 3
HgenePTPRDchr9:8314247chr12:72666463ENST00000397606-12924_11401506.0DomainNote=Ig-like C2-type 1
HgenePTPRDchr9:8314247chr12:72666463ENST00000397606-129325_41501506.0DomainFibronectin type-III 1
HgenePTPRDchr9:8314247chr12:72666463ENST00000397606-129420_51601506.0DomainFibronectin type-III 2
HgenePTPRDchr9:8314247chr12:72666463ENST00000397606-129518_60701506.0DomainFibronectin type-III 3
HgenePTPRDchr9:8314247chr12:72666463ENST00000397606-129612_70901506.0DomainFibronectin type-III 4
HgenePTPRDchr9:8314247chr12:72666463ENST00000397606-129714_82201506.0DomainFibronectin type-III 5
HgenePTPRDchr9:8314247chr12:72666463ENST00000397606-129823_91601506.0DomainFibronectin type-III 6
HgenePTPRDchr9:8314247chr12:72666463ENST00000397606-129921_101601506.0DomainFibronectin type-III 7
HgenePTPRDchr9:8314247chr12:72666463ENST00000486161-1311020_110601506.0DomainFibronectin type-III 8
HgenePTPRDchr9:8314247chr12:72666463ENST00000486161-131126_22401506.0DomainNote=Ig-like C2-type 2
HgenePTPRDchr9:8314247chr12:72666463ENST00000486161-1311357_161201506.0DomainTyrosine-protein phosphatase 1
HgenePTPRDchr9:8314247chr12:72666463ENST00000486161-1311644_190301506.0DomainTyrosine-protein phosphatase 2
HgenePTPRDchr9:8314247chr12:72666463ENST00000486161-131236_31801506.0DomainNote=Ig-like C2-type 3
HgenePTPRDchr9:8314247chr12:72666463ENST00000486161-13124_11401506.0DomainNote=Ig-like C2-type 1
HgenePTPRDchr9:8314247chr12:72666463ENST00000486161-131325_41501506.0DomainFibronectin type-III 1
HgenePTPRDchr9:8314247chr12:72666463ENST00000486161-131420_51601506.0DomainFibronectin type-III 2
HgenePTPRDchr9:8314247chr12:72666463ENST00000486161-131518_60701506.0DomainFibronectin type-III 3
HgenePTPRDchr9:8314247chr12:72666463ENST00000486161-131612_70901506.0DomainFibronectin type-III 4
HgenePTPRDchr9:8314247chr12:72666463ENST00000486161-131714_82201506.0DomainFibronectin type-III 5
HgenePTPRDchr9:8314247chr12:72666463ENST00000486161-131823_91601506.0DomainFibronectin type-III 6
HgenePTPRDchr9:8314247chr12:72666463ENST00000486161-131921_101601506.0DomainFibronectin type-III 7
HgenePTPRDchr9:8314247chr12:72666463ENST00000540109-1361020_110601952.3333333333333DomainFibronectin type-III 8
HgenePTPRDchr9:8314247chr12:72666463ENST00000540109-136126_22401952.3333333333333DomainNote=Ig-like C2-type 2
HgenePTPRDchr9:8314247chr12:72666463ENST00000540109-1361357_161201952.3333333333333DomainTyrosine-protein phosphatase 1
HgenePTPRDchr9:8314247chr12:72666463ENST00000540109-1361644_190301952.3333333333333DomainTyrosine-protein phosphatase 2
HgenePTPRDchr9:8314247chr12:72666463ENST00000540109-136236_31801952.3333333333333DomainNote=Ig-like C2-type 3
HgenePTPRDchr9:8314247chr12:72666463ENST00000540109-13624_11401952.3333333333333DomainNote=Ig-like C2-type 1
HgenePTPRDchr9:8314247chr12:72666463ENST00000540109-136325_41501952.3333333333333DomainFibronectin type-III 1
HgenePTPRDchr9:8314247chr12:72666463ENST00000540109-136420_51601952.3333333333333DomainFibronectin type-III 2
HgenePTPRDchr9:8314247chr12:72666463ENST00000540109-136518_60701952.3333333333333DomainFibronectin type-III 3
HgenePTPRDchr9:8314247chr12:72666463ENST00000540109-136612_70901952.3333333333333DomainFibronectin type-III 4
HgenePTPRDchr9:8314247chr12:72666463ENST00000540109-136714_82201952.3333333333333DomainFibronectin type-III 5
HgenePTPRDchr9:8314247chr12:72666463ENST00000540109-136823_91601952.3333333333333DomainFibronectin type-III 6
HgenePTPRDchr9:8314247chr12:72666463ENST00000540109-136921_101601952.3333333333333DomainFibronectin type-III 7
HgenePTPRDchr9:8314247chr12:72666463ENST00000397606-1291553_155901506.0RegionSubstrate binding
HgenePTPRDchr9:8314247chr12:72666463ENST00000486161-1311553_155901506.0RegionSubstrate binding
HgenePTPRDchr9:8314247chr12:72666463ENST00000540109-1361553_155901952.3333333333333RegionSubstrate binding
HgenePTPRDchr9:8314247chr12:72666463ENST00000397606-1291291_191201506.0Topological domainCytoplasmic
HgenePTPRDchr9:8314247chr12:72666463ENST00000397606-12921_126501506.0Topological domainExtracellular
HgenePTPRDchr9:8314247chr12:72666463ENST00000486161-1311291_191201506.0Topological domainCytoplasmic
HgenePTPRDchr9:8314247chr12:72666463ENST00000486161-13121_126501506.0Topological domainExtracellular
HgenePTPRDchr9:8314247chr12:72666463ENST00000540109-1361291_191201952.3333333333333Topological domainCytoplasmic
HgenePTPRDchr9:8314247chr12:72666463ENST00000540109-13621_126501952.3333333333333Topological domainExtracellular
HgenePTPRDchr9:8314247chr12:72666463ENST00000397606-1291266_129001506.0TransmembraneHelical
HgenePTPRDchr9:8314247chr12:72666463ENST00000486161-1311266_129001506.0TransmembraneHelical
HgenePTPRDchr9:8314247chr12:72666463ENST00000540109-1361266_129001952.3333333333333TransmembraneHelical
TgeneTRHDEchr9:8314247chr12:72666463ENST00000261180-1191_40259.66666666666671025.0Topological domainCytoplasmic
TgeneTRHDEchr9:8314247chr12:72666463ENST00000261180-11962_1024259.66666666666671025.0Topological domainExtracellular
TgeneTRHDEchr9:8314247chr12:72666463ENST00000261180-11941_61259.66666666666671025.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PTPRD
TRHDE


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePTPRDchr9:8314247chr12:72666463ENST00000397606-129180_18901506.0IL1RAPL1
HgenePTPRDchr9:8314247chr12:72666463ENST00000486161-131180_18901506.0IL1RAPL1
HgenePTPRDchr9:8314247chr12:72666463ENST00000540109-136180_18901952.3333333333333IL1RAPL1


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Related Drugs to PTPRD-TRHDE


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PTPRD-TRHDE


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource