UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:PTPRK-RSPO3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PTPRK-RSPO3
FusionPDB ID: 70459
FusionGDB2.0 ID: 70459
HgeneTgene
Gene symbol

PTPRK

RSPO3

Gene ID

5796

84870

Gene nameprotein tyrosine phosphatase receptor type KR-spondin 3
SynonymsR-PTP-kappaCRISTIN1|PWTSR|THSD2
Cytomap

6q22.33

6q22.33

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase kappadJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappaprotein-tyrosine phosphatase kappaprotein-tyrosine phosphaR-spondin-3R-spondin 3 homologprotein with TSP type-1 repeatroof plate-specific spondin-3thrombospondin type-1 domain-containing protein 2thrombospondin, type I, domain containing 2
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000368207, ENST00000368210, 
ENST00000368213, ENST00000368215, 
ENST00000368226, ENST00000368227, 
ENST00000525459, ENST00000532331, 
ENST00000524481, 		ENST00000485757, 
ENST00000356698, ENST00000368317, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score36 X 18 X 16=103684 X 3 X 5=60
# samples 489
** MAII scorelog2(48/10368*10)=-4.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/60*10)=0.584962500721156
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PTPRK [Title/Abstract] AND RSPO3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PTPRK(128841404)-RSPO3(127469793), # samples:15
Anticipated loss of major functional domain due to fusion event.PTPRK-RSPO3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPRK-RSPO3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPRK-RSPO3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPRK-RSPO3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPRK-RSPO3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PTPRK-RSPO3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PTPRK-RSPO3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PTPRK-RSPO3 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
PTPRK-RSPO3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
PTPRK-RSPO3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPRK

GO:0006470

protein dephosphorylation

16263724

HgenePTPRK

GO:0007165

signal transduction

16849327

HgenePTPRK

GO:0007179

transforming growth factor beta receptor signaling pathway

15899872

HgenePTPRK

GO:0008285

negative regulation of cell proliferation

15899872|18276111

HgenePTPRK

GO:0010839

negative regulation of keratinocyte proliferation

16263724

HgenePTPRK

GO:0030336

negative regulation of cell migration

18276111

HgenePTPRK

GO:0034394

protein localization to cell surface

18276111

HgenePTPRK

GO:0034614

cellular response to reactive oxygen species

16849327

HgenePTPRK

GO:0034644

cellular response to UV

16849327

HgenePTPRK

GO:0045786

negative regulation of cell cycle

15899872

HgenePTPRK

GO:0045892

negative regulation of transcription, DNA-templated

18276111

TgeneRSPO3

GO:0030177

positive regulation of Wnt signaling pathway

29769720


check buttonFusion gene breakpoints across PTPRK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RSPO3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-A6-2672-01APTPRKchr6

128841404

-RSPO3chr6

127469793

+
ChimerDB4COADTCGA-AA-3518-01APTPRKchr6

128841404

-RSPO3chr6

127469793

+
ChimerDB4COADTCGA-AA-3664-01APTPRKchr6

128841404

-RSPO3chr6

127469793

+
ChimerDB4COADTCGA-AA-3842-01APTPRKchr6

128841404

-RSPO3chr6

127469793

+
ChimerDB4COADTCGA-CA-5255-01APTPRKchr6

128841404

-RSPO3chr6

127469793

+
ChimerDB4COADTCGA-D5-6539-01APTPRKchr6

128841404

-RSPO3chr6

127469793

+
ChimerDB4COADTCGA-DM-A1HB-01APTPRKchr6

128505577

-RSPO3chr6

127469793

+
ChimerDB4COADTCGA-DM-A1HBPTPRKchr6

128505576

-RSPO3chr6

127469792

+
ChimerDB4COADTCGA-QG-A5YX-01APTPRKchr6

128841404

-RSPO3chr6

127469793

+
ChimerDB4ESCATCGA-JY-A938-01APTPRKchr6

128505577

-RSPO3chr6

127469793

+
ChimerDB4ESCATCGA-JY-A938PTPRKchr6

128505576

-RSPO3chr6

127469792

+
ChimerDB4ESCATCGA-JY-A938PTPRKchr6

128505577

-RSPO3chr6

127469793

+
ChimerDB4READTCGA-AF-6136-01APTPRKchr6

128841404

-RSPO3chr6

127469793

+
ChimerDB4READTCGA-AF-6136PTPRKchr6

128841404

-RSPO3chr6

127469793

+
ChimerDB4READTCGA-DT-5265-01APTPRKchr6

128841404

-RSPO3chr6

127469793

+
ChimerDB4READTCGA-DT-5265PTPRKchr6

128841404

-RSPO3chr6

127469793

+
ChimerDB4READTCGA-G5-6233-01APTPRKchr6

128505577

-RSPO3chr6

127469793

+
ChimerDB4READTCGA-G5-6233PTPRKchr6

128505576

-RSPO3chr6

127469792

+
ChimerDB4READTCGA-G5-6233PTPRKchr6

128505577

-RSPO3chr6

127469793

+
ChimerDB4STADTCGA-VQ-A92DPTPRKchr6

128385902

-RSPO3chr6

127469792

+
ChimerDB4STADTCGA-VQ-AA68-01APTPRKchr6

128841404

-RSPO3chr6

127469793

+
ChimerKB3..PTPRKchr6

128841403

-RSPO3chr6

127469792

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000368226PTPRKchr6128505576-ENST00000356698RSPO3chr6127469792+348914781092199696
ENST00000368226PTPRKchr6128505576-ENST00000368317RSPO3chr6127469792+251614781092259716
ENST00000368227PTPRKchr6128505576-ENST00000356698RSPO3chr6127469792+354015291602250696
ENST00000368227PTPRKchr6128505576-ENST00000368317RSPO3chr6127469792+256715291602310716
ENST00000532331PTPRKchr6128505576-ENST00000356698RSPO3chr6127469792+32911280912001636
ENST00000532331PTPRKchr6128505576-ENST00000368317RSPO3chr6127469792+23181280912061656
ENST00000368213PTPRKchr6128505576-ENST00000356698RSPO3chr6127469792+33981387182108696
ENST00000368213PTPRKchr6128505576-ENST00000368317RSPO3chr6127469792+24251387182168716
ENST00000368210PTPRKchr6128505576-ENST00000356698RSPO3chr6127469792+34311420512141696
ENST00000368210PTPRKchr6128505576-ENST00000368317RSPO3chr6127469792+24581420512201716
ENST00000368215PTPRKchr6128505576-ENST00000356698RSPO3chr6127469792+3173116201883627
ENST00000368215PTPRKchr6128505576-ENST00000368317RSPO3chr6127469792+2200116201943647
ENST00000368207PTPRKchr6128505576-ENST00000356698RSPO3chr6127469792+33981387182108696
ENST00000368207PTPRKchr6128505576-ENST00000368317RSPO3chr6127469792+24251387182168716
ENST00000368226PTPRKchr6128385902-ENST00000356698RSPO3chr6127469792+4521251010932311040
ENST00000368226PTPRKchr6128385902-ENST00000368317RSPO3chr6127469792+3548251010932911060
ENST00000368227PTPRKchr6128385902-ENST00000356698RSPO3chr6127469792+4572256116032821040
ENST00000368227PTPRKchr6128385902-ENST00000368317RSPO3chr6127469792+3599256116033421060
ENST00000532331PTPRKchr6128385902-ENST00000356698RSPO3chr6127469792+43232312913033980
ENST00000532331PTPRKchr6128385902-ENST00000368317RSPO3chr6127469792+335023129130931000
ENST00000368213PTPRKchr6128385902-ENST00000356698RSPO3chr6127469792+443024191831401040
ENST00000368213PTPRKchr6128385902-ENST00000368317RSPO3chr6127469792+345724191832001060
ENST00000368210PTPRKchr6128385902-ENST00000356698RSPO3chr6127469792+446324525131731040
ENST00000368210PTPRKchr6128385902-ENST00000368317RSPO3chr6127469792+349024525132331060
ENST00000368215PTPRKchr6128385902-ENST00000356698RSPO3chr6127469792+4205219402915971
ENST00000368215PTPRKchr6128385902-ENST00000368317RSPO3chr6127469792+3232219402975991
ENST00000368207PTPRKchr6128385902-ENST00000356698RSPO3chr6127469792+443024191831401040
ENST00000368207PTPRKchr6128385902-ENST00000368317RSPO3chr6127469792+345724191832001060
ENST00000368226PTPRKchr6128505577-ENST00000356698RSPO3chr6127469793+348914781092199696
ENST00000368226PTPRKchr6128505577-ENST00000368317RSPO3chr6127469793+251614781092259716
ENST00000368227PTPRKchr6128505577-ENST00000356698RSPO3chr6127469793+354015291602250696
ENST00000368227PTPRKchr6128505577-ENST00000368317RSPO3chr6127469793+256715291602310716
ENST00000532331PTPRKchr6128505577-ENST00000356698RSPO3chr6127469793+32911280912001636
ENST00000532331PTPRKchr6128505577-ENST00000368317RSPO3chr6127469793+23181280912061656
ENST00000368213PTPRKchr6128505577-ENST00000356698RSPO3chr6127469793+33981387182108696
ENST00000368213PTPRKchr6128505577-ENST00000368317RSPO3chr6127469793+24251387182168716
ENST00000368210PTPRKchr6128505577-ENST00000356698RSPO3chr6127469793+34311420512141696
ENST00000368210PTPRKchr6128505577-ENST00000368317RSPO3chr6127469793+24581420512201716
ENST00000368215PTPRKchr6128505577-ENST00000356698RSPO3chr6127469793+3173116201883627
ENST00000368215PTPRKchr6128505577-ENST00000368317RSPO3chr6127469793+2200116201943647
ENST00000368207PTPRKchr6128505577-ENST00000356698RSPO3chr6127469793+33981387182108696
ENST00000368207PTPRKchr6128505577-ENST00000368317RSPO3chr6127469793+24251387182168716

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368226ENST00000356698PTPRKchr6128505576-RSPO3chr6127469792+0.0006527330.99934727
ENST00000368226ENST00000368317PTPRKchr6128505576-RSPO3chr6127469792+0.00236290.99763715
ENST00000368227ENST00000356698PTPRKchr6128505576-RSPO3chr6127469792+0.0006921850.9993079
ENST00000368227ENST00000368317PTPRKchr6128505576-RSPO3chr6127469792+0.0025746960.9974253
ENST00000532331ENST00000356698PTPRKchr6128505576-RSPO3chr6127469792+0.00055020.9994498
ENST00000532331ENST00000368317PTPRKchr6128505576-RSPO3chr6127469792+0.0017436910.99825627
ENST00000368213ENST00000356698PTPRKchr6128505576-RSPO3chr6127469792+0.0006121280.99938786
ENST00000368213ENST00000368317PTPRKchr6128505576-RSPO3chr6127469792+0.0020275330.9979724
ENST00000368210ENST00000356698PTPRKchr6128505576-RSPO3chr6127469792+0.0006488550.9993511
ENST00000368210ENST00000368317PTPRKchr6128505576-RSPO3chr6127469792+0.0021310630.9978689
ENST00000368215ENST00000356698PTPRKchr6128505576-RSPO3chr6127469792+0.0004958150.9995042
ENST00000368215ENST00000368317PTPRKchr6128505576-RSPO3chr6127469792+0.0014677080.9985323
ENST00000368207ENST00000356698PTPRKchr6128505576-RSPO3chr6127469792+0.0006121280.99938786
ENST00000368207ENST00000368317PTPRKchr6128505576-RSPO3chr6127469792+0.0020275330.9979724
ENST00000368226ENST00000356698PTPRKchr6128385902-RSPO3chr6127469792+0.0002786490.99972135
ENST00000368226ENST00000368317PTPRKchr6128385902-RSPO3chr6127469792+0.0007019720.999298
ENST00000368227ENST00000356698PTPRKchr6128385902-RSPO3chr6127469792+0.000305180.9996948
ENST00000368227ENST00000368317PTPRKchr6128385902-RSPO3chr6127469792+0.0007843540.9992156
ENST00000532331ENST00000356698PTPRKchr6128385902-RSPO3chr6127469792+0.0002358650.99976414
ENST00000532331ENST00000368317PTPRKchr6128385902-RSPO3chr6127469792+0.0005120180.999488
ENST00000368213ENST00000356698PTPRKchr6128385902-RSPO3chr6127469792+0.0002577120.9997423
ENST00000368213ENST00000368317PTPRKchr6128385902-RSPO3chr6127469792+0.0006270050.999373
ENST00000368210ENST00000356698PTPRKchr6128385902-RSPO3chr6127469792+0.0002648740.99973506
ENST00000368210ENST00000368317PTPRKchr6128385902-RSPO3chr6127469792+0.0006637280.9993363
ENST00000368215ENST00000356698PTPRKchr6128385902-RSPO3chr6127469792+0.000221460.99977857
ENST00000368215ENST00000368317PTPRKchr6128385902-RSPO3chr6127469792+0.0004519330.999548
ENST00000368207ENST00000356698PTPRKchr6128385902-RSPO3chr6127469792+0.0002577120.9997423
ENST00000368207ENST00000368317PTPRKchr6128385902-RSPO3chr6127469792+0.0006270050.999373
ENST00000368226ENST00000356698PTPRKchr6128505577-RSPO3chr6127469793+0.0006527330.99934727
ENST00000368226ENST00000368317PTPRKchr6128505577-RSPO3chr6127469793+0.00236290.99763715
ENST00000368227ENST00000356698PTPRKchr6128505577-RSPO3chr6127469793+0.0006921850.9993079
ENST00000368227ENST00000368317PTPRKchr6128505577-RSPO3chr6127469793+0.0025746960.9974253
ENST00000532331ENST00000356698PTPRKchr6128505577-RSPO3chr6127469793+0.00055020.9994498
ENST00000532331ENST00000368317PTPRKchr6128505577-RSPO3chr6127469793+0.0017436910.99825627
ENST00000368213ENST00000356698PTPRKchr6128505577-RSPO3chr6127469793+0.0006121280.99938786
ENST00000368213ENST00000368317PTPRKchr6128505577-RSPO3chr6127469793+0.0020275330.9979724
ENST00000368210ENST00000356698PTPRKchr6128505577-RSPO3chr6127469793+0.0006488550.9993511
ENST00000368210ENST00000368317PTPRKchr6128505577-RSPO3chr6127469793+0.0021310630.9978689
ENST00000368215ENST00000356698PTPRKchr6128505577-RSPO3chr6127469793+0.0004958150.9995042
ENST00000368215ENST00000368317PTPRKchr6128505577-RSPO3chr6127469793+0.0014677080.9985323
ENST00000368207ENST00000356698PTPRKchr6128505577-RSPO3chr6127469793+0.0006121280.99938786
ENST00000368207ENST00000368317PTPRKchr6128505577-RSPO3chr6127469793+0.0020275330.9979724

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>70459_70459_1_PTPRK-RSPO3_PTPRK_chr6_128385902_ENST00000368207_RSPO3_chr6_127469792_ENST00000356698_length(amino acids)=1040AA_BP=800
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTN
PEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHL
HPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMEC
YQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKVHPNVSQGCQ
GGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEG
LEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKK

--------------------------------------------------------------

>70459_70459_2_PTPRK-RSPO3_PTPRK_chr6_128385902_ENST00000368207_RSPO3_chr6_127469792_ENST00000368317_length(amino acids)=1060AA_BP=800
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTN
PEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHL
HPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMEC
YQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKVHPNVSQGCQ
GGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEG
LEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKK

--------------------------------------------------------------

>70459_70459_3_PTPRK-RSPO3_PTPRK_chr6_128385902_ENST00000368210_RSPO3_chr6_127469792_ENST00000356698_length(amino acids)=1040AA_BP=800
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTN
PEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHL
HPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMEC
YQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKVHPNVSQGCQ
GGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEG
LEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKK

--------------------------------------------------------------

>70459_70459_4_PTPRK-RSPO3_PTPRK_chr6_128385902_ENST00000368210_RSPO3_chr6_127469792_ENST00000368317_length(amino acids)=1060AA_BP=800
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTN
PEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHL
HPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMEC
YQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKVHPNVSQGCQ
GGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEG
LEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKK

--------------------------------------------------------------

>70459_70459_5_PTPRK-RSPO3_PTPRK_chr6_128385902_ENST00000368213_RSPO3_chr6_127469792_ENST00000356698_length(amino acids)=1040AA_BP=800
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTN
PEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHL
HPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMEC
YQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKVHPNVSQGCQ
GGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEG
LEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKK

--------------------------------------------------------------

>70459_70459_6_PTPRK-RSPO3_PTPRK_chr6_128385902_ENST00000368213_RSPO3_chr6_127469792_ENST00000368317_length(amino acids)=1060AA_BP=800
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTN
PEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHL
HPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMEC
YQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKVHPNVSQGCQ
GGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEG
LEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKK

--------------------------------------------------------------

>70459_70459_7_PTPRK-RSPO3_PTPRK_chr6_128385902_ENST00000368215_RSPO3_chr6_127469792_ENST00000356698_length(amino acids)=971AA_BP=731
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEK
ARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI
AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRC
VTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYE
IRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAP
QHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPV
AGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAY
QIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKE
TKTQCVRIATKVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFC
TKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTV

--------------------------------------------------------------

>70459_70459_8_PTPRK-RSPO3_PTPRK_chr6_128385902_ENST00000368215_RSPO3_chr6_127469792_ENST00000368317_length(amino acids)=991AA_BP=731
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEK
ARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI
AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRC
VTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYE
IRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAP
QHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPV
AGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAY
QIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKE
TKTQCVRIATKVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFC
TKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTV
QRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLESSKEIPEQRENKQQQKKRKVQDKQKSGIEVTLAEGLTSVSQRTQPTPCRRRY

--------------------------------------------------------------

>70459_70459_9_PTPRK-RSPO3_PTPRK_chr6_128385902_ENST00000368226_RSPO3_chr6_127469792_ENST00000356698_length(amino acids)=1040AA_BP=800
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTN
PEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHL
HPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMEC
YQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKVHPNVSQGCQ
GGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEG
LEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKK

--------------------------------------------------------------

>70459_70459_10_PTPRK-RSPO3_PTPRK_chr6_128385902_ENST00000368226_RSPO3_chr6_127469792_ENST00000368317_length(amino acids)=1060AA_BP=800
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTN
PEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHL
HPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMEC
YQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKVHPNVSQGCQ
GGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEG
LEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKK

--------------------------------------------------------------

>70459_70459_11_PTPRK-RSPO3_PTPRK_chr6_128385902_ENST00000368227_RSPO3_chr6_127469792_ENST00000356698_length(amino acids)=1040AA_BP=800
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTN
PEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHL
HPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMEC
YQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKVHPNVSQGCQ
GGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEG
LEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKK

--------------------------------------------------------------

>70459_70459_12_PTPRK-RSPO3_PTPRK_chr6_128385902_ENST00000368227_RSPO3_chr6_127469792_ENST00000368317_length(amino acids)=1060AA_BP=800
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTN
PEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHL
HPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMEC
YQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKVHPNVSQGCQ
GGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEG
LEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKK

--------------------------------------------------------------

>70459_70459_13_PTPRK-RSPO3_PTPRK_chr6_128385902_ENST00000532331_RSPO3_chr6_127469792_ENST00000356698_length(amino acids)=980AA_BP=740
MLETSPKLGMDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVD
SSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAE
VSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVT
KTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLW
HLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKAD
CLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSI
RSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQ
AKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYF
QAMSSVEKETKTQCVRIATKVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADC
DTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPP

--------------------------------------------------------------

>70459_70459_14_PTPRK-RSPO3_PTPRK_chr6_128385902_ENST00000532331_RSPO3_chr6_127469792_ENST00000368317_length(amino acids)=1000AA_BP=740
MLETSPKLGMDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVD
SSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAE
VSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVT
KTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLW
HLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKAD
CLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSI
RSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQ
AKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYF
QAMSSVEKETKTQCVRIATKVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADC
DTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPP
TNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLESSKEIPEQRENKQQQKKRKVQDKQKSGIEVTLAEGLTSVSQRT

--------------------------------------------------------------

>70459_70459_15_PTPRK-RSPO3_PTPRK_chr6_128505576_ENST00000368207_RSPO3_chr6_127469792_ENST00000356698_length(amino acids)=696AA_BP=456
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKS
GFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKC

--------------------------------------------------------------

>70459_70459_16_PTPRK-RSPO3_PTPRK_chr6_128505576_ENST00000368207_RSPO3_chr6_127469792_ENST00000368317_length(amino acids)=716AA_BP=456
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKS
GFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKC

--------------------------------------------------------------

>70459_70459_17_PTPRK-RSPO3_PTPRK_chr6_128505576_ENST00000368210_RSPO3_chr6_127469792_ENST00000356698_length(amino acids)=696AA_BP=456
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKS
GFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKC

--------------------------------------------------------------

>70459_70459_18_PTPRK-RSPO3_PTPRK_chr6_128505576_ENST00000368210_RSPO3_chr6_127469792_ENST00000368317_length(amino acids)=716AA_BP=456
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKS
GFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKC

--------------------------------------------------------------

>70459_70459_19_PTPRK-RSPO3_PTPRK_chr6_128505576_ENST00000368213_RSPO3_chr6_127469792_ENST00000356698_length(amino acids)=696AA_BP=456
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKS
GFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKC

--------------------------------------------------------------

>70459_70459_20_PTPRK-RSPO3_PTPRK_chr6_128505576_ENST00000368213_RSPO3_chr6_127469792_ENST00000368317_length(amino acids)=716AA_BP=456
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKS
GFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKC

--------------------------------------------------------------

>70459_70459_21_PTPRK-RSPO3_PTPRK_chr6_128505576_ENST00000368215_RSPO3_chr6_127469792_ENST00000356698_length(amino acids)=627AA_BP=387
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEK
ARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI
AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRC
VTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYE
IRVLLTRPGEGGTGLPGPPLITRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKC
TKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSA

--------------------------------------------------------------

>70459_70459_22_PTPRK-RSPO3_PTPRK_chr6_128505576_ENST00000368215_RSPO3_chr6_127469792_ENST00000368317_length(amino acids)=647AA_BP=387
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEK
ARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI
AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRC
VTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYE
IRVLLTRPGEGGTGLPGPPLITRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKC
TKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSA
KGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLESSKEIPEQRENKQQQKKRKVQDKQKSGIEVTLAEGL

--------------------------------------------------------------

>70459_70459_23_PTPRK-RSPO3_PTPRK_chr6_128505576_ENST00000368226_RSPO3_chr6_127469792_ENST00000356698_length(amino acids)=696AA_BP=456
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKS
GFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKC

--------------------------------------------------------------

>70459_70459_24_PTPRK-RSPO3_PTPRK_chr6_128505576_ENST00000368226_RSPO3_chr6_127469792_ENST00000368317_length(amino acids)=716AA_BP=456
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKS
GFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKC

--------------------------------------------------------------

>70459_70459_25_PTPRK-RSPO3_PTPRK_chr6_128505576_ENST00000368227_RSPO3_chr6_127469792_ENST00000356698_length(amino acids)=696AA_BP=456
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKS
GFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKC

--------------------------------------------------------------

>70459_70459_26_PTPRK-RSPO3_PTPRK_chr6_128505576_ENST00000368227_RSPO3_chr6_127469792_ENST00000368317_length(amino acids)=716AA_BP=456
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKS
GFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKC

--------------------------------------------------------------

>70459_70459_27_PTPRK-RSPO3_PTPRK_chr6_128505576_ENST00000532331_RSPO3_chr6_127469792_ENST00000356698_length(amino acids)=636AA_BP=396
MLETSPKLGMDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVD
SSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAE
VSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVT
KTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLW
HLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYG
TRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRV
REIIQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLESSKEIPEQRENKQQQKKRKVQDKQKSV

--------------------------------------------------------------

>70459_70459_28_PTPRK-RSPO3_PTPRK_chr6_128505576_ENST00000532331_RSPO3_chr6_127469792_ENST00000368317_length(amino acids)=656AA_BP=396
MLETSPKLGMDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVD
SSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAE
VSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVT
KTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLW
HLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYG
TRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRV
REIIQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLESSKEIPEQRENKQQQKKRKVQDKQKSG

--------------------------------------------------------------

>70459_70459_29_PTPRK-RSPO3_PTPRK_chr6_128505577_ENST00000368207_RSPO3_chr6_127469793_ENST00000356698_length(amino acids)=696AA_BP=456
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKS
GFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKC

--------------------------------------------------------------

>70459_70459_30_PTPRK-RSPO3_PTPRK_chr6_128505577_ENST00000368207_RSPO3_chr6_127469793_ENST00000368317_length(amino acids)=716AA_BP=456
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKS
GFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKC

--------------------------------------------------------------

>70459_70459_31_PTPRK-RSPO3_PTPRK_chr6_128505577_ENST00000368210_RSPO3_chr6_127469793_ENST00000356698_length(amino acids)=696AA_BP=456
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKS
GFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKC

--------------------------------------------------------------

>70459_70459_32_PTPRK-RSPO3_PTPRK_chr6_128505577_ENST00000368210_RSPO3_chr6_127469793_ENST00000368317_length(amino acids)=716AA_BP=456
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKS
GFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKC

--------------------------------------------------------------

>70459_70459_33_PTPRK-RSPO3_PTPRK_chr6_128505577_ENST00000368213_RSPO3_chr6_127469793_ENST00000356698_length(amino acids)=696AA_BP=456
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKS
GFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKC

--------------------------------------------------------------

>70459_70459_34_PTPRK-RSPO3_PTPRK_chr6_128505577_ENST00000368213_RSPO3_chr6_127469793_ENST00000368317_length(amino acids)=716AA_BP=456
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKS
GFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKC

--------------------------------------------------------------

>70459_70459_35_PTPRK-RSPO3_PTPRK_chr6_128505577_ENST00000368215_RSPO3_chr6_127469793_ENST00000356698_length(amino acids)=627AA_BP=387
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEK
ARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI
AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRC
VTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYE
IRVLLTRPGEGGTGLPGPPLITRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKC
TKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSA

--------------------------------------------------------------

>70459_70459_36_PTPRK-RSPO3_PTPRK_chr6_128505577_ENST00000368215_RSPO3_chr6_127469793_ENST00000368317_length(amino acids)=647AA_BP=387
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEK
ARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI
AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRC
VTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYE
IRVLLTRPGEGGTGLPGPPLITRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKC
TKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSA
KGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLESSKEIPEQRENKQQQKKRKVQDKQKSGIEVTLAEGL

--------------------------------------------------------------

>70459_70459_37_PTPRK-RSPO3_PTPRK_chr6_128505577_ENST00000368226_RSPO3_chr6_127469793_ENST00000356698_length(amino acids)=696AA_BP=456
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKS
GFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKC

--------------------------------------------------------------

>70459_70459_38_PTPRK-RSPO3_PTPRK_chr6_128505577_ENST00000368226_RSPO3_chr6_127469793_ENST00000368317_length(amino acids)=716AA_BP=456
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKS
GFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKC

--------------------------------------------------------------

>70459_70459_39_PTPRK-RSPO3_PTPRK_chr6_128505577_ENST00000368227_RSPO3_chr6_127469793_ENST00000356698_length(amino acids)=696AA_BP=456
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKS
GFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKC

--------------------------------------------------------------

>70459_70459_40_PTPRK-RSPO3_PTPRK_chr6_128505577_ENST00000368227_RSPO3_chr6_127469793_ENST00000368317_length(amino acids)=716AA_BP=456
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI
TRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKS
GFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKC

--------------------------------------------------------------

>70459_70459_41_PTPRK-RSPO3_PTPRK_chr6_128505577_ENST00000532331_RSPO3_chr6_127469793_ENST00000356698_length(amino acids)=636AA_BP=396
MLETSPKLGMDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVD
SSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAE
VSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVT
KTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLW
HLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYG
TRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRV
REIIQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLESSKEIPEQRENKQQQKKRKVQDKQKSV

--------------------------------------------------------------

>70459_70459_42_PTPRK-RSPO3_PTPRK_chr6_128505577_ENST00000532331_RSPO3_chr6_127469793_ENST00000368317_length(amino acids)=656AA_BP=396
MLETSPKLGMDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVD
SSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAE
VSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVT
KTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLW
HLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAVHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYG
TRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRV
REIIQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLESSKEIPEQRENKQQQKKRKVQDKQKSG

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:128841404/chr6:127469793)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRKchr6:128385902chr6:127469792ENST00000368213-1331196_281731.33333333333341447.0DomainNote=Ig-like C2-type
HgenePTPRKchr6:128385902chr6:127469792ENST00000368213-1331294_389731.33333333333341447.0DomainFibronectin type-III 1
HgenePTPRKchr6:128385902chr6:127469792ENST00000368213-133131_194731.33333333333341447.0DomainMAM
HgenePTPRKchr6:128385902chr6:127469792ENST00000368213-1331392_488731.33333333333341447.0DomainFibronectin type-III 2
HgenePTPRKchr6:128385902chr6:127469792ENST00000368213-1331491_595731.33333333333341447.0DomainFibronectin type-III 3
HgenePTPRKchr6:128385902chr6:127469792ENST00000368213-1331597_680731.33333333333341447.0DomainFibronectin type-III 4
HgenePTPRKchr6:128385902chr6:127469792ENST00000368215-1330196_281731.33333333333341440.0DomainNote=Ig-like C2-type
HgenePTPRKchr6:128385902chr6:127469792ENST00000368215-1330294_389731.33333333333341440.0DomainFibronectin type-III 1
HgenePTPRKchr6:128385902chr6:127469792ENST00000368215-133031_194731.33333333333341440.0DomainMAM
HgenePTPRKchr6:128385902chr6:127469792ENST00000368215-1330392_488731.33333333333341440.0DomainFibronectin type-III 2
HgenePTPRKchr6:128385902chr6:127469792ENST00000368215-1330491_595731.33333333333341440.0DomainFibronectin type-III 3
HgenePTPRKchr6:128385902chr6:127469792ENST00000368215-1330597_680731.33333333333341440.0DomainFibronectin type-III 4
HgenePTPRKchr6:128385902chr6:127469792ENST00000368226-1330196_281731.33333333333341441.0DomainNote=Ig-like C2-type
HgenePTPRKchr6:128385902chr6:127469792ENST00000368226-1330294_389731.33333333333341441.0DomainFibronectin type-III 1
HgenePTPRKchr6:128385902chr6:127469792ENST00000368226-133031_194731.33333333333341441.0DomainMAM
HgenePTPRKchr6:128385902chr6:127469792ENST00000368226-1330392_488731.33333333333341441.0DomainFibronectin type-III 2
HgenePTPRKchr6:128385902chr6:127469792ENST00000368226-1330491_595731.33333333333341441.0DomainFibronectin type-III 3
HgenePTPRKchr6:128385902chr6:127469792ENST00000368226-1330597_680731.33333333333341441.0DomainFibronectin type-III 4
HgenePTPRKchr6:128505576chr6:127469792ENST00000368213-731196_281387.33333333333331447.0DomainNote=Ig-like C2-type
HgenePTPRKchr6:128505576chr6:127469792ENST00000368213-731294_389387.33333333333331447.0DomainFibronectin type-III 1
HgenePTPRKchr6:128505576chr6:127469792ENST00000368213-73131_194387.33333333333331447.0DomainMAM
HgenePTPRKchr6:128505576chr6:127469792ENST00000368215-730196_281387.33333333333331440.0DomainNote=Ig-like C2-type
HgenePTPRKchr6:128505576chr6:127469792ENST00000368215-730294_389387.33333333333331440.0DomainFibronectin type-III 1
HgenePTPRKchr6:128505576chr6:127469792ENST00000368215-73031_194387.33333333333331440.0DomainMAM
HgenePTPRKchr6:128505576chr6:127469792ENST00000368226-730196_281387.33333333333331441.0DomainNote=Ig-like C2-type
HgenePTPRKchr6:128505576chr6:127469792ENST00000368226-730294_389387.33333333333331441.0DomainFibronectin type-III 1
HgenePTPRKchr6:128505576chr6:127469792ENST00000368226-73031_194387.33333333333331441.0DomainMAM
HgenePTPRKchr6:128505577chr6:127469793ENST00000368213-731196_281387.33333333333331447.0DomainNote=Ig-like C2-type
HgenePTPRKchr6:128505577chr6:127469793ENST00000368213-731294_389387.33333333333331447.0DomainFibronectin type-III 1
HgenePTPRKchr6:128505577chr6:127469793ENST00000368213-73131_194387.33333333333331447.0DomainMAM
HgenePTPRKchr6:128505577chr6:127469793ENST00000368215-730196_281387.33333333333331440.0DomainNote=Ig-like C2-type
HgenePTPRKchr6:128505577chr6:127469793ENST00000368215-730294_389387.33333333333331440.0DomainFibronectin type-III 1
HgenePTPRKchr6:128505577chr6:127469793ENST00000368215-73031_194387.33333333333331440.0DomainMAM
HgenePTPRKchr6:128505577chr6:127469793ENST00000368226-730196_281387.33333333333331441.0DomainNote=Ig-like C2-type
HgenePTPRKchr6:128505577chr6:127469793ENST00000368226-730294_389387.33333333333331441.0DomainFibronectin type-III 1
HgenePTPRKchr6:128505577chr6:127469793ENST00000368226-73031_194387.33333333333331441.0DomainMAM
TgeneRSPO3chr6:128385902chr6:127469792ENST0000035669805147_20732.333333333333336273.0DomainTSP type-1
TgeneRSPO3chr6:128385902chr6:127469792ENST0000036831706147_20732.333333333333336293.0DomainTSP type-1
TgeneRSPO3chr6:128505576chr6:127469792ENST0000035669805147_20732.333333333333336273.0DomainTSP type-1
TgeneRSPO3chr6:128505576chr6:127469792ENST0000036831706147_20732.333333333333336293.0DomainTSP type-1
TgeneRSPO3chr6:128505577chr6:127469793ENST0000035669805147_20732.333333333333336273.0DomainTSP type-1
TgeneRSPO3chr6:128505577chr6:127469793ENST0000036831706147_20732.333333333333336293.0DomainTSP type-1
TgeneRSPO3chr6:128385902chr6:127469792ENST000003566980535_8632.333333333333336273.0RepeatNote=FU 1
TgeneRSPO3chr6:128385902chr6:127469792ENST000003566980592_13532.333333333333336273.0RepeatNote=FU 2
TgeneRSPO3chr6:128385902chr6:127469792ENST000003683170635_8632.333333333333336293.0RepeatNote=FU 1
TgeneRSPO3chr6:128385902chr6:127469792ENST000003683170692_13532.333333333333336293.0RepeatNote=FU 2
TgeneRSPO3chr6:128505576chr6:127469792ENST000003566980535_8632.333333333333336273.0RepeatNote=FU 1
TgeneRSPO3chr6:128505576chr6:127469792ENST000003566980592_13532.333333333333336273.0RepeatNote=FU 2
TgeneRSPO3chr6:128505576chr6:127469792ENST000003683170635_8632.333333333333336293.0RepeatNote=FU 1
TgeneRSPO3chr6:128505576chr6:127469792ENST000003683170692_13532.333333333333336293.0RepeatNote=FU 2
TgeneRSPO3chr6:128505577chr6:127469793ENST000003566980535_8632.333333333333336273.0RepeatNote=FU 1
TgeneRSPO3chr6:128505577chr6:127469793ENST000003566980592_13532.333333333333336273.0RepeatNote=FU 2
TgeneRSPO3chr6:128505577chr6:127469793ENST000003683170635_8632.333333333333336293.0RepeatNote=FU 1
TgeneRSPO3chr6:128505577chr6:127469793ENST000003683170692_13532.333333333333336293.0RepeatNote=FU 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRKchr6:128385902chr6:127469792ENST00000368213-13311173_1435731.33333333333341447.0DomainTyrosine-protein phosphatase 2
HgenePTPRKchr6:128385902chr6:127469792ENST00000368213-1331887_1141731.33333333333341447.0DomainTyrosine-protein phosphatase 1
HgenePTPRKchr6:128385902chr6:127469792ENST00000368215-13301173_1435731.33333333333341440.0DomainTyrosine-protein phosphatase 2
HgenePTPRKchr6:128385902chr6:127469792ENST00000368215-1330887_1141731.33333333333341440.0DomainTyrosine-protein phosphatase 1
HgenePTPRKchr6:128385902chr6:127469792ENST00000368226-13301173_1435731.33333333333341441.0DomainTyrosine-protein phosphatase 2
HgenePTPRKchr6:128385902chr6:127469792ENST00000368226-1330887_1141731.33333333333341441.0DomainTyrosine-protein phosphatase 1
HgenePTPRKchr6:128505576chr6:127469792ENST00000368213-7311173_1435387.33333333333331447.0DomainTyrosine-protein phosphatase 2
HgenePTPRKchr6:128505576chr6:127469792ENST00000368213-731392_488387.33333333333331447.0DomainFibronectin type-III 2
HgenePTPRKchr6:128505576chr6:127469792ENST00000368213-731491_595387.33333333333331447.0DomainFibronectin type-III 3
HgenePTPRKchr6:128505576chr6:127469792ENST00000368213-731597_680387.33333333333331447.0DomainFibronectin type-III 4
HgenePTPRKchr6:128505576chr6:127469792ENST00000368213-731887_1141387.33333333333331447.0DomainTyrosine-protein phosphatase 1
HgenePTPRKchr6:128505576chr6:127469792ENST00000368215-7301173_1435387.33333333333331440.0DomainTyrosine-protein phosphatase 2
HgenePTPRKchr6:128505576chr6:127469792ENST00000368215-730392_488387.33333333333331440.0DomainFibronectin type-III 2
HgenePTPRKchr6:128505576chr6:127469792ENST00000368215-730491_595387.33333333333331440.0DomainFibronectin type-III 3
HgenePTPRKchr6:128505576chr6:127469792ENST00000368215-730597_680387.33333333333331440.0DomainFibronectin type-III 4
HgenePTPRKchr6:128505576chr6:127469792ENST00000368215-730887_1141387.33333333333331440.0DomainTyrosine-protein phosphatase 1
HgenePTPRKchr6:128505576chr6:127469792ENST00000368226-7301173_1435387.33333333333331441.0DomainTyrosine-protein phosphatase 2
HgenePTPRKchr6:128505576chr6:127469792ENST00000368226-730392_488387.33333333333331441.0DomainFibronectin type-III 2
HgenePTPRKchr6:128505576chr6:127469792ENST00000368226-730491_595387.33333333333331441.0DomainFibronectin type-III 3
HgenePTPRKchr6:128505576chr6:127469792ENST00000368226-730597_680387.33333333333331441.0DomainFibronectin type-III 4
HgenePTPRKchr6:128505576chr6:127469792ENST00000368226-730887_1141387.33333333333331441.0DomainTyrosine-protein phosphatase 1
HgenePTPRKchr6:128505577chr6:127469793ENST00000368213-7311173_1435387.33333333333331447.0DomainTyrosine-protein phosphatase 2
HgenePTPRKchr6:128505577chr6:127469793ENST00000368213-731392_488387.33333333333331447.0DomainFibronectin type-III 2
HgenePTPRKchr6:128505577chr6:127469793ENST00000368213-731491_595387.33333333333331447.0DomainFibronectin type-III 3
HgenePTPRKchr6:128505577chr6:127469793ENST00000368213-731597_680387.33333333333331447.0DomainFibronectin type-III 4
HgenePTPRKchr6:128505577chr6:127469793ENST00000368213-731887_1141387.33333333333331447.0DomainTyrosine-protein phosphatase 1
HgenePTPRKchr6:128505577chr6:127469793ENST00000368215-7301173_1435387.33333333333331440.0DomainTyrosine-protein phosphatase 2
HgenePTPRKchr6:128505577chr6:127469793ENST00000368215-730392_488387.33333333333331440.0DomainFibronectin type-III 2
HgenePTPRKchr6:128505577chr6:127469793ENST00000368215-730491_595387.33333333333331440.0DomainFibronectin type-III 3
HgenePTPRKchr6:128505577chr6:127469793ENST00000368215-730597_680387.33333333333331440.0DomainFibronectin type-III 4
HgenePTPRKchr6:128505577chr6:127469793ENST00000368215-730887_1141387.33333333333331440.0DomainTyrosine-protein phosphatase 1
HgenePTPRKchr6:128505577chr6:127469793ENST00000368226-7301173_1435387.33333333333331441.0DomainTyrosine-protein phosphatase 2
HgenePTPRKchr6:128505577chr6:127469793ENST00000368226-730392_488387.33333333333331441.0DomainFibronectin type-III 2
HgenePTPRKchr6:128505577chr6:127469793ENST00000368226-730491_595387.33333333333331441.0DomainFibronectin type-III 3
HgenePTPRKchr6:128505577chr6:127469793ENST00000368226-730597_680387.33333333333331441.0DomainFibronectin type-III 4
HgenePTPRKchr6:128505577chr6:127469793ENST00000368226-730887_1141387.33333333333331441.0DomainTyrosine-protein phosphatase 1
HgenePTPRKchr6:128385902chr6:127469792ENST00000368213-13311082_1088731.33333333333341447.0RegionSubstrate binding
HgenePTPRKchr6:128385902chr6:127469792ENST00000368215-13301082_1088731.33333333333341440.0RegionSubstrate binding
HgenePTPRKchr6:128385902chr6:127469792ENST00000368226-13301082_1088731.33333333333341441.0RegionSubstrate binding
HgenePTPRKchr6:128505576chr6:127469792ENST00000368213-7311082_1088387.33333333333331447.0RegionSubstrate binding
HgenePTPRKchr6:128505576chr6:127469792ENST00000368215-7301082_1088387.33333333333331440.0RegionSubstrate binding
HgenePTPRKchr6:128505576chr6:127469792ENST00000368226-7301082_1088387.33333333333331441.0RegionSubstrate binding
HgenePTPRKchr6:128505577chr6:127469793ENST00000368213-7311082_1088387.33333333333331447.0RegionSubstrate binding
HgenePTPRKchr6:128505577chr6:127469793ENST00000368215-7301082_1088387.33333333333331440.0RegionSubstrate binding
HgenePTPRKchr6:128505577chr6:127469793ENST00000368226-7301082_1088387.33333333333331441.0RegionSubstrate binding
HgenePTPRKchr6:128385902chr6:127469792ENST00000368213-133127_752731.33333333333341447.0Topological domainExtracellular
HgenePTPRKchr6:128385902chr6:127469792ENST00000368213-1331775_1439731.33333333333341447.0Topological domainCytoplasmic
HgenePTPRKchr6:128385902chr6:127469792ENST00000368215-133027_752731.33333333333341440.0Topological domainExtracellular
HgenePTPRKchr6:128385902chr6:127469792ENST00000368215-1330775_1439731.33333333333341440.0Topological domainCytoplasmic
HgenePTPRKchr6:128385902chr6:127469792ENST00000368226-133027_752731.33333333333341441.0Topological domainExtracellular
HgenePTPRKchr6:128385902chr6:127469792ENST00000368226-1330775_1439731.33333333333341441.0Topological domainCytoplasmic
HgenePTPRKchr6:128505576chr6:127469792ENST00000368213-73127_752387.33333333333331447.0Topological domainExtracellular
HgenePTPRKchr6:128505576chr6:127469792ENST00000368213-731775_1439387.33333333333331447.0Topological domainCytoplasmic
HgenePTPRKchr6:128505576chr6:127469792ENST00000368215-73027_752387.33333333333331440.0Topological domainExtracellular
HgenePTPRKchr6:128505576chr6:127469792ENST00000368215-730775_1439387.33333333333331440.0Topological domainCytoplasmic
HgenePTPRKchr6:128505576chr6:127469792ENST00000368226-73027_752387.33333333333331441.0Topological domainExtracellular
HgenePTPRKchr6:128505576chr6:127469792ENST00000368226-730775_1439387.33333333333331441.0Topological domainCytoplasmic
HgenePTPRKchr6:128505577chr6:127469793ENST00000368213-73127_752387.33333333333331447.0Topological domainExtracellular
HgenePTPRKchr6:128505577chr6:127469793ENST00000368213-731775_1439387.33333333333331447.0Topological domainCytoplasmic
HgenePTPRKchr6:128505577chr6:127469793ENST00000368215-73027_752387.33333333333331440.0Topological domainExtracellular
HgenePTPRKchr6:128505577chr6:127469793ENST00000368215-730775_1439387.33333333333331440.0Topological domainCytoplasmic
HgenePTPRKchr6:128505577chr6:127469793ENST00000368226-73027_752387.33333333333331441.0Topological domainExtracellular
HgenePTPRKchr6:128505577chr6:127469793ENST00000368226-730775_1439387.33333333333331441.0Topological domainCytoplasmic
HgenePTPRKchr6:128385902chr6:127469792ENST00000368213-1331753_774731.33333333333341447.0TransmembraneHelical
HgenePTPRKchr6:128385902chr6:127469792ENST00000368215-1330753_774731.33333333333341440.0TransmembraneHelical
HgenePTPRKchr6:128385902chr6:127469792ENST00000368226-1330753_774731.33333333333341441.0TransmembraneHelical
HgenePTPRKchr6:128505576chr6:127469792ENST00000368213-731753_774387.33333333333331447.0TransmembraneHelical
HgenePTPRKchr6:128505576chr6:127469792ENST00000368215-730753_774387.33333333333331440.0TransmembraneHelical
HgenePTPRKchr6:128505576chr6:127469792ENST00000368226-730753_774387.33333333333331441.0TransmembraneHelical
HgenePTPRKchr6:128505577chr6:127469793ENST00000368213-731753_774387.33333333333331447.0TransmembraneHelical
HgenePTPRKchr6:128505577chr6:127469793ENST00000368215-730753_774387.33333333333331440.0TransmembraneHelical
HgenePTPRKchr6:128505577chr6:127469793ENST00000368226-730753_774387.33333333333331441.0TransmembraneHelical


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PTPRK
RSPO3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to PTPRK-RSPO3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to PTPRK-RSPO3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource