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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PTPRK-SMNDC1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PTPRK-SMNDC1
	FusionPDB ID: 70463
	FusionGDB2.0 ID: 70463
		Hgene	Tgene
	Gene symbol	PTPRK	SMNDC1
	Gene ID	5796	10285
	Gene name	protein tyrosine phosphatase receptor type K	survival motor neuron domain containing 1
	Synonyms	R-PTP-kappa	SMNR\|SPF30\|TDRD16C
	Cytomap	6q22.33	10q25.2
	Type of gene	protein-coding	protein-coding
	Description	receptor-type tyrosine-protein phosphatase kappadJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappaprotein-tyrosine phosphatase kappaprotein-tyrosine phospha	survival of motor neuron-related-splicing factor 3030 kDa splicing factor SMNrpSMN-related proteinsplicing factor 30, survival of motor neuron-relatedsurvival motor neuron domain-containing protein 1tudor domain containing 16C
	Modification date	20200322	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000368207, ENST00000368210, ENST00000368213, ENST00000368215, ENST00000368226, ENST00000368227, ENST00000532331, ENST00000524481, ENST00000525459,	ENST00000471297, ENST00000369592, ENST00000369603,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	36 X 18 X 16=10368	4 X 5 X 2=40
	# samples	48	5
	** MAII score	log2(48/10368*10)=-4.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PTPRK [Title/Abstract] AND SMNDC1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PTPRK(128561180)-SMNDC1(112058548), # samples:3
Anticipated loss of major functional domain due to fusion event.	PTPRK-SMNDC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PTPRK-SMNDC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PTPRK-SMNDC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PTPRK-SMNDC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PTPRK	GO:0006470	protein dephosphorylation	16263724
Hgene	PTPRK	GO:0007165	signal transduction	16849327
Hgene	PTPRK	GO:0007179	transforming growth factor beta receptor signaling pathway	15899872
Hgene	PTPRK	GO:0008285	negative regulation of cell proliferation	15899872\|18276111
Hgene	PTPRK	GO:0010839	negative regulation of keratinocyte proliferation	16263724
Hgene	PTPRK	GO:0030336	negative regulation of cell migration	18276111
Hgene	PTPRK	GO:0034394	protein localization to cell surface	18276111
Hgene	PTPRK	GO:0034614	cellular response to reactive oxygen species	16849327
Hgene	PTPRK	GO:0034644	cellular response to UV	16849327
Hgene	PTPRK	GO:0045786	negative regulation of cell cycle	15899872
Hgene	PTPRK	GO:0045892	negative regulation of transcription, DNA-templated	18276111

Fusion gene breakpoints across PTPRK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SMNDC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	CHOL	TCGA-ZH-A8Y1-01A	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058547	-
ChimerDB4	CHOL	TCGA-ZH-A8Y1-01A	PTPRK	chr6	128561180	-	SMNDC1	chr10	112058548	-
ChimerDB4	CHOL	TCGA-ZH-A8Y1	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058548	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000368226	PTPRK	chr6	128561180	-	ENST00000369603	SMNDC1	chr10	112058548	-	5026	1009	109	1605	498
ENST00000368226	PTPRK	chr6	128561180	-	ENST00000369592	SMNDC1	chr10	112058548	-	1694	1009	109	1605	498
ENST00000368227	PTPRK	chr6	128561180	-	ENST00000369603	SMNDC1	chr10	112058548	-	5077	1060	160	1656	498
ENST00000368227	PTPRK	chr6	128561180	-	ENST00000369592	SMNDC1	chr10	112058548	-	1745	1060	160	1656	498
ENST00000532331	PTPRK	chr6	128561180	-	ENST00000369603	SMNDC1	chr10	112058548	-	4828	811	91	1407	438
ENST00000532331	PTPRK	chr6	128561180	-	ENST00000369592	SMNDC1	chr10	112058548	-	1496	811	91	1407	438
ENST00000368213	PTPRK	chr6	128561180	-	ENST00000369603	SMNDC1	chr10	112058548	-	4935	918	18	1514	498
ENST00000368213	PTPRK	chr6	128561180	-	ENST00000369592	SMNDC1	chr10	112058548	-	1603	918	18	1514	498
ENST00000368210	PTPRK	chr6	128561180	-	ENST00000369603	SMNDC1	chr10	112058548	-	4968	951	51	1547	498
ENST00000368210	PTPRK	chr6	128561180	-	ENST00000369592	SMNDC1	chr10	112058548	-	1636	951	51	1547	498
ENST00000368215	PTPRK	chr6	128561180	-	ENST00000369603	SMNDC1	chr10	112058548	-	4710	693	0	1289	429
ENST00000368215	PTPRK	chr6	128561180	-	ENST00000369592	SMNDC1	chr10	112058548	-	1378	693	0	1289	429
ENST00000368207	PTPRK	chr6	128561180	-	ENST00000369603	SMNDC1	chr10	112058548	-	4935	918	18	1514	498
ENST00000368207	PTPRK	chr6	128561180	-	ENST00000369592	SMNDC1	chr10	112058548	-	1603	918	18	1514	498
ENST00000368226	PTPRK	chr6	128561179	-	ENST00000369603	SMNDC1	chr10	112058548	-	5026	1009	109	1605	498
ENST00000368226	PTPRK	chr6	128561179	-	ENST00000369592	SMNDC1	chr10	112058548	-	1694	1009	109	1605	498
ENST00000368227	PTPRK	chr6	128561179	-	ENST00000369603	SMNDC1	chr10	112058548	-	5077	1060	160	1656	498
ENST00000368227	PTPRK	chr6	128561179	-	ENST00000369592	SMNDC1	chr10	112058548	-	1745	1060	160	1656	498
ENST00000532331	PTPRK	chr6	128561179	-	ENST00000369603	SMNDC1	chr10	112058548	-	4828	811	91	1407	438
ENST00000532331	PTPRK	chr6	128561179	-	ENST00000369592	SMNDC1	chr10	112058548	-	1496	811	91	1407	438
ENST00000368213	PTPRK	chr6	128561179	-	ENST00000369603	SMNDC1	chr10	112058548	-	4935	918	18	1514	498
ENST00000368213	PTPRK	chr6	128561179	-	ENST00000369592	SMNDC1	chr10	112058548	-	1603	918	18	1514	498
ENST00000368210	PTPRK	chr6	128561179	-	ENST00000369603	SMNDC1	chr10	112058548	-	4968	951	51	1547	498
ENST00000368210	PTPRK	chr6	128561179	-	ENST00000369592	SMNDC1	chr10	112058548	-	1636	951	51	1547	498
ENST00000368215	PTPRK	chr6	128561179	-	ENST00000369603	SMNDC1	chr10	112058548	-	4710	693	0	1289	429
ENST00000368215	PTPRK	chr6	128561179	-	ENST00000369592	SMNDC1	chr10	112058548	-	1378	693	0	1289	429
ENST00000368207	PTPRK	chr6	128561179	-	ENST00000369603	SMNDC1	chr10	112058548	-	4935	918	18	1514	498
ENST00000368207	PTPRK	chr6	128561179	-	ENST00000369592	SMNDC1	chr10	112058548	-	1603	918	18	1514	498
ENST00000368226	PTPRK	chr6	128561179	-	ENST00000369603	SMNDC1	chr10	112058547	-	5026	1009	109	1605	498
ENST00000368226	PTPRK	chr6	128561179	-	ENST00000369592	SMNDC1	chr10	112058547	-	1694	1009	109	1605	498
ENST00000368227	PTPRK	chr6	128561179	-	ENST00000369603	SMNDC1	chr10	112058547	-	5077	1060	160	1656	498
ENST00000368227	PTPRK	chr6	128561179	-	ENST00000369592	SMNDC1	chr10	112058547	-	1745	1060	160	1656	498
ENST00000532331	PTPRK	chr6	128561179	-	ENST00000369603	SMNDC1	chr10	112058547	-	4828	811	91	1407	438
ENST00000532331	PTPRK	chr6	128561179	-	ENST00000369592	SMNDC1	chr10	112058547	-	1496	811	91	1407	438
ENST00000368213	PTPRK	chr6	128561179	-	ENST00000369603	SMNDC1	chr10	112058547	-	4935	918	18	1514	498
ENST00000368213	PTPRK	chr6	128561179	-	ENST00000369592	SMNDC1	chr10	112058547	-	1603	918	18	1514	498
ENST00000368210	PTPRK	chr6	128561179	-	ENST00000369603	SMNDC1	chr10	112058547	-	4968	951	51	1547	498
ENST00000368210	PTPRK	chr6	128561179	-	ENST00000369592	SMNDC1	chr10	112058547	-	1636	951	51	1547	498
ENST00000368215	PTPRK	chr6	128561179	-	ENST00000369603	SMNDC1	chr10	112058547	-	4710	693	0	1289	429
ENST00000368215	PTPRK	chr6	128561179	-	ENST00000369592	SMNDC1	chr10	112058547	-	1378	693	0	1289	429
ENST00000368207	PTPRK	chr6	128561179	-	ENST00000369603	SMNDC1	chr10	112058547	-	4935	918	18	1514	498
ENST00000368207	PTPRK	chr6	128561179	-	ENST00000369592	SMNDC1	chr10	112058547	-	1603	918	18	1514	498

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000368226	ENST00000369603	PTPRK	chr6	128561180	-	SMNDC1	chr10	112058548	-	8.55E-05	0.9999145
ENST00000368226	ENST00000369592	PTPRK	chr6	128561180	-	SMNDC1	chr10	112058548	-	0.001153463	0.99884653
ENST00000368227	ENST00000369603	PTPRK	chr6	128561180	-	SMNDC1	chr10	112058548	-	8.85E-05	0.99991155
ENST00000368227	ENST00000369592	PTPRK	chr6	128561180	-	SMNDC1	chr10	112058548	-	0.001268524	0.99873143
ENST00000532331	ENST00000369603	PTPRK	chr6	128561180	-	SMNDC1	chr10	112058548	-	7.68E-05	0.9999232
ENST00000532331	ENST00000369592	PTPRK	chr6	128561180	-	SMNDC1	chr10	112058548	-	0.00087948	0.99912053
ENST00000368213	ENST00000369603	PTPRK	chr6	128561180	-	SMNDC1	chr10	112058548	-	8.10E-05	0.99991894
ENST00000368213	ENST00000369592	PTPRK	chr6	128561180	-	SMNDC1	chr10	112058548	-	0.000923823	0.9990761
ENST00000368210	ENST00000369603	PTPRK	chr6	128561180	-	SMNDC1	chr10	112058548	-	8.36E-05	0.9999163
ENST00000368210	ENST00000369592	PTPRK	chr6	128561180	-	SMNDC1	chr10	112058548	-	0.000976567	0.99902344
ENST00000368215	ENST00000369603	PTPRK	chr6	128561180	-	SMNDC1	chr10	112058548	-	7.08E-05	0.9999292
ENST00000368215	ENST00000369592	PTPRK	chr6	128561180	-	SMNDC1	chr10	112058548	-	0.000877168	0.9991228
ENST00000368207	ENST00000369603	PTPRK	chr6	128561180	-	SMNDC1	chr10	112058548	-	8.10E-05	0.99991894
ENST00000368207	ENST00000369592	PTPRK	chr6	128561180	-	SMNDC1	chr10	112058548	-	0.000923823	0.9990761
ENST00000368226	ENST00000369603	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058548	-	8.55E-05	0.9999145
ENST00000368226	ENST00000369592	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058548	-	0.001153463	0.99884653
ENST00000368227	ENST00000369603	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058548	-	8.85E-05	0.99991155
ENST00000368227	ENST00000369592	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058548	-	0.001268524	0.99873143
ENST00000532331	ENST00000369603	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058548	-	7.68E-05	0.9999232
ENST00000532331	ENST00000369592	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058548	-	0.00087948	0.99912053
ENST00000368213	ENST00000369603	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058548	-	8.10E-05	0.99991894
ENST00000368213	ENST00000369592	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058548	-	0.000923823	0.9990761
ENST00000368210	ENST00000369603	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058548	-	8.36E-05	0.9999163
ENST00000368210	ENST00000369592	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058548	-	0.000976567	0.99902344
ENST00000368215	ENST00000369603	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058548	-	7.08E-05	0.9999292
ENST00000368215	ENST00000369592	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058548	-	0.000877168	0.9991228
ENST00000368207	ENST00000369603	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058548	-	8.10E-05	0.99991894
ENST00000368207	ENST00000369592	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058548	-	0.000923823	0.9990761
ENST00000368226	ENST00000369603	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058547	-	8.55E-05	0.9999145
ENST00000368226	ENST00000369592	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058547	-	0.001153463	0.99884653
ENST00000368227	ENST00000369603	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058547	-	8.85E-05	0.99991155
ENST00000368227	ENST00000369592	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058547	-	0.001268524	0.99873143
ENST00000532331	ENST00000369603	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058547	-	7.68E-05	0.9999232
ENST00000532331	ENST00000369592	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058547	-	0.00087948	0.99912053
ENST00000368213	ENST00000369603	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058547	-	8.10E-05	0.99991894
ENST00000368213	ENST00000369592	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058547	-	0.000923823	0.9990761
ENST00000368210	ENST00000369603	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058547	-	8.36E-05	0.9999163
ENST00000368210	ENST00000369592	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058547	-	0.000976567	0.99902344
ENST00000368215	ENST00000369603	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058547	-	7.08E-05	0.9999292
ENST00000368215	ENST00000369592	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058547	-	0.000877168	0.9991228
ENST00000368207	ENST00000369603	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058547	-	8.10E-05	0.99991894
ENST00000368207	ENST00000369592	PTPRK	chr6	128561179	-	SMNDC1	chr10	112058547	-	0.000923823	0.9990761

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>70463_70463_1_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368207_SMNDC1_chr10_112058547_ENST00000369592_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_2_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368207_SMNDC1_chr10_112058547_ENST00000369603_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_3_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368207_SMNDC1_chr10_112058548_ENST00000369592_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_4_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368207_SMNDC1_chr10_112058548_ENST00000369603_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_5_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368210_SMNDC1_chr10_112058547_ENST00000369592_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_6_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368210_SMNDC1_chr10_112058547_ENST00000369603_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_7_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368210_SMNDC1_chr10_112058548_ENST00000369592_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_8_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368210_SMNDC1_chr10_112058548_ENST00000369603_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_9_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368213_SMNDC1_chr10_112058547_ENST00000369592_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_10_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368213_SMNDC1_chr10_112058547_ENST00000369603_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_11_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368213_SMNDC1_chr10_112058548_ENST00000369592_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_12_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368213_SMNDC1_chr10_112058548_ENST00000369603_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_13_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368215_SMNDC1_chr10_112058547_ENST00000369592_length(amino acids)=429AA_BP=231
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEK
ARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI
AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKC
MAVWSEDGQCYEAEIEEIDEENGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQ

--------------------------------------------------------------

>70463_70463_14_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368215_SMNDC1_chr10_112058547_ENST00000369603_length(amino acids)=429AA_BP=231
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEK
ARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI
AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKC
MAVWSEDGQCYEAEIEEIDEENGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQ

--------------------------------------------------------------

>70463_70463_15_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368215_SMNDC1_chr10_112058548_ENST00000369592_length(amino acids)=429AA_BP=231
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEK
ARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI
AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKC
MAVWSEDGQCYEAEIEEIDEENGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQ

--------------------------------------------------------------

>70463_70463_16_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368215_SMNDC1_chr10_112058548_ENST00000369603_length(amino acids)=429AA_BP=231
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEK
ARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI
AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKC
MAVWSEDGQCYEAEIEEIDEENGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQ

--------------------------------------------------------------

>70463_70463_17_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368226_SMNDC1_chr10_112058547_ENST00000369592_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_18_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368226_SMNDC1_chr10_112058547_ENST00000369603_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_19_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368226_SMNDC1_chr10_112058548_ENST00000369592_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_20_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368226_SMNDC1_chr10_112058548_ENST00000369603_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_21_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368227_SMNDC1_chr10_112058547_ENST00000369592_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_22_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368227_SMNDC1_chr10_112058547_ENST00000369603_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_23_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368227_SMNDC1_chr10_112058548_ENST00000369592_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_24_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000368227_SMNDC1_chr10_112058548_ENST00000369603_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_25_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000532331_SMNDC1_chr10_112058547_ENST00000369592_length(amino acids)=438AA_BP=240
MLETSPKLGMDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVD
SSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAE
VSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPT
HSWKVGDKCMAVWSEDGQCYEAEIEEIDEENGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKK

--------------------------------------------------------------

>70463_70463_26_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000532331_SMNDC1_chr10_112058547_ENST00000369603_length(amino acids)=438AA_BP=240
MLETSPKLGMDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVD
SSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAE
VSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPT
HSWKVGDKCMAVWSEDGQCYEAEIEEIDEENGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKK

--------------------------------------------------------------

>70463_70463_27_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000532331_SMNDC1_chr10_112058548_ENST00000369592_length(amino acids)=438AA_BP=240
MLETSPKLGMDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVD
SSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAE
VSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPT
HSWKVGDKCMAVWSEDGQCYEAEIEEIDEENGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKK

--------------------------------------------------------------

>70463_70463_28_PTPRK-SMNDC1_PTPRK_chr6_128561179_ENST00000532331_SMNDC1_chr10_112058548_ENST00000369603_length(amino acids)=438AA_BP=240
MLETSPKLGMDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVD
SSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAE
VSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPT
HSWKVGDKCMAVWSEDGQCYEAEIEEIDEENGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKK

--------------------------------------------------------------

>70463_70463_29_PTPRK-SMNDC1_PTPRK_chr6_128561180_ENST00000368207_SMNDC1_chr10_112058548_ENST00000369592_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_30_PTPRK-SMNDC1_PTPRK_chr6_128561180_ENST00000368207_SMNDC1_chr10_112058548_ENST00000369603_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_31_PTPRK-SMNDC1_PTPRK_chr6_128561180_ENST00000368210_SMNDC1_chr10_112058548_ENST00000369592_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_32_PTPRK-SMNDC1_PTPRK_chr6_128561180_ENST00000368210_SMNDC1_chr10_112058548_ENST00000369603_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_33_PTPRK-SMNDC1_PTPRK_chr6_128561180_ENST00000368213_SMNDC1_chr10_112058548_ENST00000369592_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_34_PTPRK-SMNDC1_PTPRK_chr6_128561180_ENST00000368213_SMNDC1_chr10_112058548_ENST00000369603_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_35_PTPRK-SMNDC1_PTPRK_chr6_128561180_ENST00000368215_SMNDC1_chr10_112058548_ENST00000369592_length(amino acids)=429AA_BP=231
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEK
ARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI
AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKC
MAVWSEDGQCYEAEIEEIDEENGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQ

--------------------------------------------------------------

>70463_70463_36_PTPRK-SMNDC1_PTPRK_chr6_128561180_ENST00000368215_SMNDC1_chr10_112058548_ENST00000369603_length(amino acids)=429AA_BP=231
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEK
ARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI
AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKC
MAVWSEDGQCYEAEIEEIDEENGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQ

--------------------------------------------------------------

>70463_70463_37_PTPRK-SMNDC1_PTPRK_chr6_128561180_ENST00000368226_SMNDC1_chr10_112058548_ENST00000369592_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_38_PTPRK-SMNDC1_PTPRK_chr6_128561180_ENST00000368226_SMNDC1_chr10_112058548_ENST00000369603_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_39_PTPRK-SMNDC1_PTPRK_chr6_128561180_ENST00000368227_SMNDC1_chr10_112058548_ENST00000369592_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_40_PTPRK-SMNDC1_PTPRK_chr6_128561180_ENST00000368227_SMNDC1_chr10_112058548_ENST00000369603_length(amino acids)=498AA_BP=300
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEE
NGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNK

--------------------------------------------------------------

>70463_70463_41_PTPRK-SMNDC1_PTPRK_chr6_128561180_ENST00000532331_SMNDC1_chr10_112058548_ENST00000369592_length(amino acids)=438AA_BP=240
MLETSPKLGMDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVD
SSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAE
VSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPT
HSWKVGDKCMAVWSEDGQCYEAEIEEIDEENGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKK

--------------------------------------------------------------

>70463_70463_42_PTPRK-SMNDC1_PTPRK_chr6_128561180_ENST00000532331_SMNDC1_chr10_112058548_ENST00000369603_length(amino acids)=438AA_BP=240
MLETSPKLGMDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVD
SSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAE
VSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQEVIELTKDLLSTQPSETLASSDSFASTQPT
HSWKVGDKCMAVWSEDGQCYEAEIEEIDEENGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKK

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:128561180/chr10:112058548)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368213

31_194

231.0

1447.0

Domain

MAM

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368215

31_194

231.0

1440.0

Domain

MAM

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368226

31_194

231.0

1441.0

Domain

MAM

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368213

31_194

231.0

1447.0

Domain

MAM

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368215

31_194

231.0

1440.0

Domain

MAM

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368226

31_194

231.0

1441.0

Domain

MAM

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368213

31_194

231.0

1447.0

Domain

MAM

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368215

31_194

231.0

1440.0

Domain

MAM

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368226

31_194

231.0

1441.0

Domain

MAM

Tgene

SMNDC1

chr6:128561179

chr10:112058547

ENST00000369592

72_132

40.0

239.0

Domain

Tudor

Tgene

SMNDC1

chr6:128561179

chr10:112058547

ENST00000369603

72_132

40.0

239.0

Domain

Tudor

Tgene

SMNDC1

chr6:128561179

chr10:112058548

ENST00000369592

72_132

40.0

239.0

Domain

Tudor

Tgene

SMNDC1

chr6:128561179

chr10:112058548

ENST00000369603

72_132

40.0

239.0

Domain

Tudor

Tgene

SMNDC1

chr6:128561180

chr10:112058548

ENST00000369592

72_132

40.0

239.0

Domain

Tudor

Tgene

SMNDC1

chr6:128561180

chr10:112058548

ENST00000369603

72_132

40.0

239.0

Domain

Tudor

Tgene

SMNDC1

chr6:128561179

chr10:112058547

ENST00000369592

142_160

40.0

239.0

Motif

Nuclear localization signal

Tgene

SMNDC1

chr6:128561179

chr10:112058547

ENST00000369603

142_160

40.0

239.0

Motif

Nuclear localization signal

Tgene

SMNDC1

chr6:128561179

chr10:112058548

ENST00000369592

142_160

40.0

239.0

Motif

Nuclear localization signal

Tgene

SMNDC1

chr6:128561179

chr10:112058548

ENST00000369603

142_160

40.0

239.0

Motif

Nuclear localization signal

Tgene

SMNDC1

chr6:128561180

chr10:112058548

ENST00000369592

142_160

40.0

239.0

Motif

Nuclear localization signal

Tgene

SMNDC1

chr6:128561180

chr10:112058548

ENST00000369603

142_160

40.0

239.0

Motif

Nuclear localization signal

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368213

1173_1435

231.0

1447.0

Domain

Tyrosine-protein phosphatase 2

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368213

196_281

231.0

1447.0

Domain

Note=Ig-like C2-type

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368213

294_389

231.0

1447.0

Domain

Fibronectin type-III 1

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368213

392_488

231.0

1447.0

Domain

Fibronectin type-III 2

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368213

491_595

231.0

1447.0

Domain

Fibronectin type-III 3

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368213

597_680

231.0

1447.0

Domain

Fibronectin type-III 4

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368213

887_1141

231.0

1447.0

Domain

Tyrosine-protein phosphatase 1

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368215

1173_1435

231.0

1440.0

Domain

Tyrosine-protein phosphatase 2

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368215

196_281

231.0

1440.0

Domain

Note=Ig-like C2-type

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368215

294_389

231.0

1440.0

Domain

Fibronectin type-III 1

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368215

392_488

231.0

1440.0

Domain

Fibronectin type-III 2

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368215

491_595

231.0

1440.0

Domain

Fibronectin type-III 3

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368215

597_680

231.0

1440.0

Domain

Fibronectin type-III 4

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368215

887_1141

231.0

1440.0

Domain

Tyrosine-protein phosphatase 1

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368226

1173_1435

231.0

1441.0

Domain

Tyrosine-protein phosphatase 2

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368226

196_281

231.0

1441.0

Domain

Note=Ig-like C2-type

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368226

294_389

231.0

1441.0

Domain

Fibronectin type-III 1

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368226

392_488

231.0

1441.0

Domain

Fibronectin type-III 2

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368226

491_595

231.0

1441.0

Domain

Fibronectin type-III 3

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368226

597_680

231.0

1441.0

Domain

Fibronectin type-III 4

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368226

887_1141

231.0

1441.0

Domain

Tyrosine-protein phosphatase 1

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368213

1173_1435

231.0

1447.0

Domain

Tyrosine-protein phosphatase 2

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368213

196_281

231.0

1447.0

Domain

Note=Ig-like C2-type

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368213

294_389

231.0

1447.0

Domain

Fibronectin type-III 1

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368213

392_488

231.0

1447.0

Domain

Fibronectin type-III 2

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368213

491_595

231.0

1447.0

Domain

Fibronectin type-III 3

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368213

597_680

231.0

1447.0

Domain

Fibronectin type-III 4

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368213

887_1141

231.0

1447.0

Domain

Tyrosine-protein phosphatase 1

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368215

1173_1435

231.0

1440.0

Domain

Tyrosine-protein phosphatase 2

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368215

196_281

231.0

1440.0

Domain

Note=Ig-like C2-type

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368215

294_389

231.0

1440.0

Domain

Fibronectin type-III 1

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368215

392_488

231.0

1440.0

Domain

Fibronectin type-III 2

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368215

491_595

231.0

1440.0

Domain

Fibronectin type-III 3

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368215

597_680

231.0

1440.0

Domain

Fibronectin type-III 4

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368215

887_1141

231.0

1440.0

Domain

Tyrosine-protein phosphatase 1

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368226

1173_1435

231.0

1441.0

Domain

Tyrosine-protein phosphatase 2

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368226

196_281

231.0

1441.0

Domain

Note=Ig-like C2-type

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368226

294_389

231.0

1441.0

Domain

Fibronectin type-III 1

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368226

392_488

231.0

1441.0

Domain

Fibronectin type-III 2

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368226

491_595

231.0

1441.0

Domain

Fibronectin type-III 3

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368226

597_680

231.0

1441.0

Domain

Fibronectin type-III 4

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368226

887_1141

231.0

1441.0

Domain

Tyrosine-protein phosphatase 1

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368213

1173_1435

231.0

1447.0

Domain

Tyrosine-protein phosphatase 2

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368213

196_281

231.0

1447.0

Domain

Note=Ig-like C2-type

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368213

294_389

231.0

1447.0

Domain

Fibronectin type-III 1

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368213

392_488

231.0

1447.0

Domain

Fibronectin type-III 2

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368213

491_595

231.0

1447.0

Domain

Fibronectin type-III 3

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368213

597_680

231.0

1447.0

Domain

Fibronectin type-III 4

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368213

887_1141

231.0

1447.0

Domain

Tyrosine-protein phosphatase 1

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368215

1173_1435

231.0

1440.0

Domain

Tyrosine-protein phosphatase 2

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368215

196_281

231.0

1440.0

Domain

Note=Ig-like C2-type

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368215

294_389

231.0

1440.0

Domain

Fibronectin type-III 1

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368215

392_488

231.0

1440.0

Domain

Fibronectin type-III 2

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368215

491_595

231.0

1440.0

Domain

Fibronectin type-III 3

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368215

597_680

231.0

1440.0

Domain

Fibronectin type-III 4

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368215

887_1141

231.0

1440.0

Domain

Tyrosine-protein phosphatase 1

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368226

1173_1435

231.0

1441.0

Domain

Tyrosine-protein phosphatase 2

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368226

196_281

231.0

1441.0

Domain

Note=Ig-like C2-type

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368226

294_389

231.0

1441.0

Domain

Fibronectin type-III 1

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368226

392_488

231.0

1441.0

Domain

Fibronectin type-III 2

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368226

491_595

231.0

1441.0

Domain

Fibronectin type-III 3

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368226

597_680

231.0

1441.0

Domain

Fibronectin type-III 4

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368226

887_1141

231.0

1441.0

Domain

Tyrosine-protein phosphatase 1

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368213

1082_1088

231.0

1447.0

Region

Substrate binding

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368215

1082_1088

231.0

1440.0

Region

Substrate binding

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368226

1082_1088

231.0

1441.0

Region

Substrate binding

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368213

1082_1088

231.0

1447.0

Region

Substrate binding

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368215

1082_1088

231.0

1440.0

Region

Substrate binding

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368226

1082_1088

231.0

1441.0

Region

Substrate binding

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368213

1082_1088

231.0

1447.0

Region

Substrate binding

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368215

1082_1088

231.0

1440.0

Region

Substrate binding

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368226

1082_1088

231.0

1441.0

Region

Substrate binding

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368213

27_752

231.0

1447.0

Topological domain

Extracellular

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368213

775_1439

231.0

1447.0

Topological domain

Cytoplasmic

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368215

27_752

231.0

1440.0

Topological domain

Extracellular

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368215

775_1439

231.0

1440.0

Topological domain

Cytoplasmic

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368226

27_752

231.0

1441.0

Topological domain

Extracellular

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368226

775_1439

231.0

1441.0

Topological domain

Cytoplasmic

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368213

27_752

231.0

1447.0

Topological domain

Extracellular

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368213

775_1439

231.0

1447.0

Topological domain

Cytoplasmic

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368215

27_752

231.0

1440.0

Topological domain

Extracellular

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368215

775_1439

231.0

1440.0

Topological domain

Cytoplasmic

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368226

27_752

231.0

1441.0

Topological domain

Extracellular

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368226

775_1439

231.0

1441.0

Topological domain

Cytoplasmic

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368213

27_752

231.0

1447.0

Topological domain

Extracellular

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368213

775_1439

231.0

1447.0

Topological domain

Cytoplasmic

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368215

27_752

231.0

1440.0

Topological domain

Extracellular

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368215

775_1439

231.0

1440.0

Topological domain

Cytoplasmic

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368226

27_752

231.0

1441.0

Topological domain

Extracellular

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368226

775_1439

231.0

1441.0

Topological domain

Cytoplasmic

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368213

753_774

231.0

1447.0

Transmembrane

Helical

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368215

753_774

231.0

1440.0

Transmembrane

Helical

Hgene

PTPRK

chr6:128561179

chr10:112058547

ENST00000368226

753_774

231.0

1441.0

Transmembrane

Helical

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368213

753_774

231.0

1447.0

Transmembrane

Helical

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368215

753_774

231.0

1440.0

Transmembrane

Helical

Hgene

PTPRK

chr6:128561179

chr10:112058548

ENST00000368226

753_774

231.0

1441.0

Transmembrane

Helical

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368213

753_774

231.0

1447.0

Transmembrane

Helical

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368215

753_774

231.0

1440.0

Transmembrane

Helical

Hgene

PTPRK

chr6:128561180

chr10:112058548

ENST00000368226

753_774

231.0

1441.0

Transmembrane

Helical

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PTPRK
SMNDC1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to PTPRK-SMNDC1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to PTPRK-SMNDC1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source