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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PTPRK-THEMIS

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PTPRK-THEMIS
FusionPDB ID: 70468
FusionGDB2.0 ID: 70468
HgeneTgene
Gene symbol

PTPRK

THEMIS

Gene ID

5796

387357

Gene nameprotein tyrosine phosphatase receptor type Kthymocyte selection associated
SynonymsR-PTP-kappaC6orf190|C6orf207|GASP|SPOT|TSEPA
Cytomap

6q22.33

6q22.33

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase kappadJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappaprotein-tyrosine phosphatase kappaprotein-tyrosine phosphaprotein THEMISGRB2-associated proteinsignaling phosphoprotein specific for T cellsthymocyte selection pathway associatedthymocyte-expressed molecule involved in selection
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000368207, ENST00000368210, 
ENST00000368213, ENST00000368215, 
ENST00000368226, ENST00000368227, 
ENST00000532331, ENST00000524481, 
ENST00000525459, 		ENST00000368248, 
ENST00000368250, ENST00000537166, 
ENST00000543064, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score36 X 18 X 16=103686 X 7 X 5=210
# samples 4810
** MAII scorelog2(48/10368*10)=-4.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/210*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PTPRK [Title/Abstract] AND THEMIS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PTPRK(128385903)-THEMIS(128176333), # samples:1
PTPRK(128841404)-THEMIS(128040968), # samples:1
PTPRK(128505577)-THEMIS(128031161), # samples:1
PTPRK(128385903)-THEMIS(128040968), # samples:1
PTPRK(128505576)-THEMIS(128031160), # samples:1
Anticipated loss of major functional domain due to fusion event.PTPRK-THEMIS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPRK-THEMIS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPRK-THEMIS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPRK-THEMIS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPRK-THEMIS seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PTPRK-THEMIS seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PTPRK-THEMIS seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PTPRK-THEMIS seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPRK

GO:0006470

protein dephosphorylation

16263724

HgenePTPRK

GO:0007165

signal transduction

16849327

HgenePTPRK

GO:0007179

transforming growth factor beta receptor signaling pathway

15899872

HgenePTPRK

GO:0008285

negative regulation of cell proliferation

15899872|18276111

HgenePTPRK

GO:0010839

negative regulation of keratinocyte proliferation

16263724

HgenePTPRK

GO:0030336

negative regulation of cell migration

18276111

HgenePTPRK

GO:0034394

protein localization to cell surface

18276111

HgenePTPRK

GO:0034614

cellular response to reactive oxygen species

16849327

HgenePTPRK

GO:0034644

cellular response to UV

16849327

HgenePTPRK

GO:0045786

negative regulation of cell cycle

15899872

HgenePTPRK

GO:0045892

negative regulation of transcription, DNA-templated

18276111


check buttonFusion gene breakpoints across PTPRK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across THEMIS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-CF-A1HS-01APTPRKchr6

128385903

-THEMISchr6

128176333

-
ChimerDB4BRCATCGA-AN-A0FW-01APTPRKchr6

128505576

-THEMISchr6

128031160

-
ChimerDB4BRCATCGA-AN-A0FW-01APTPRKchr6

128505577

-THEMISchr6

128031161

-
ChimerDB4BRCATCGA-E2-A105-01APTPRKchr6

128841404

-THEMISchr6

128040968

-
ChimerDB4PRADTCGA-M7-A721PTPRKchr6

128385903

-THEMISchr6

128040968

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000368226PTPRKchr6128841404-ENST00000368250THEMISchr6128040968-24974165570186
ENST00000368226PTPRKchr6128841404-ENST00000368248THEMISchr6128040968-23754164572152
ENST00000368226PTPRKchr6128841404-ENST00000543064THEMISchr6128040968-23754164572152
ENST00000368226PTPRKchr6128841404-ENST00000537166THEMISchr6128040968-23754164572152
ENST00000368227PTPRKchr6128841404-ENST00000368250THEMISchr6128040968-25484676080203
ENST00000368227PTPRKchr6128841404-ENST00000368248THEMISchr6128040968-24264675082169
ENST00000368227PTPRKchr6128841404-ENST00000543064THEMISchr6128040968-24264675082169
ENST00000368227PTPRKchr6128841404-ENST00000537166THEMISchr6128040968-24264675082169
ENST00000532331PTPRKchr6128841404-ENST00000368250THEMISchr6128040968-22992182385127
ENST00000532331PTPRKchr6128841404-ENST00000368248THEMISchr6128040968-21772182385127
ENST00000532331PTPRKchr6128841404-ENST00000543064THEMISchr6128040968-21772182385127
ENST00000532331PTPRKchr6128841404-ENST00000537166THEMISchr6128040968-21772182385127
ENST00000368213PTPRKchr6128841404-ENST00000368250THEMISchr6128040968-24063254662155
ENST00000368213PTPRKchr6128841404-ENST00000368248THEMISchr6128040968-2284325109492127
ENST00000368213PTPRKchr6128841404-ENST00000543064THEMISchr6128040968-2284325109492127
ENST00000368213PTPRKchr6128841404-ENST00000537166THEMISchr6128040968-2284325109492127
ENST00000368210PTPRKchr6128841404-ENST00000368250THEMISchr6128040968-24393584992166
ENST00000368210PTPRKchr6128841404-ENST00000368248THEMISchr6128040968-23173583991133
ENST00000368210PTPRKchr6128841404-ENST00000543064THEMISchr6128040968-23173583991133
ENST00000368210PTPRKchr6128841404-ENST00000537166THEMISchr6128040968-23173583991133
ENST00000368215PTPRKchr6128841404-ENST00000368250THEMISchr6128040968-21811001026785
ENST00000368215PTPRKchr6128841404-ENST00000368248THEMISchr6128040968-20591001026785
ENST00000368215PTPRKchr6128841404-ENST00000543064THEMISchr6128040968-20591001026785
ENST00000368215PTPRKchr6128841404-ENST00000537166THEMISchr6128040968-20591001026785
ENST00000368207PTPRKchr6128841404-ENST00000368250THEMISchr6128040968-24063254662155
ENST00000368207PTPRKchr6128841404-ENST00000368248THEMISchr6128040968-2284325109492127
ENST00000368207PTPRKchr6128841404-ENST00000543064THEMISchr6128040968-2284325109492127
ENST00000368207PTPRKchr6128841404-ENST00000537166THEMISchr6128040968-2284325109492127
ENST00000525459PTPRKchr6128841404-ENST00000368250THEMISchr6128040968-24103294700157
ENST00000525459PTPRKchr6128841404-ENST00000368248THEMISchr6128040968-2288329113496127
ENST00000525459PTPRKchr6128841404-ENST00000543064THEMISchr6128040968-2288329113496127
ENST00000525459PTPRKchr6128841404-ENST00000537166THEMISchr6128040968-2288329113496127
ENST00000368226PTPRKchr6128505577-ENST00000368250THEMISchr6128031161-342314781091509466
ENST00000368227PTPRKchr6128505577-ENST00000368250THEMISchr6128031161-347415291601560466
ENST00000532331PTPRKchr6128505577-ENST00000368250THEMISchr6128031161-32251280911311406
ENST00000368213PTPRKchr6128505577-ENST00000368250THEMISchr6128031161-33321387181418466
ENST00000368210PTPRKchr6128505577-ENST00000368250THEMISchr6128031161-33651420511451466
ENST00000368215PTPRKchr6128505577-ENST00000368250THEMISchr6128031161-3107116201193397
ENST00000368207PTPRKchr6128505577-ENST00000368250THEMISchr6128031161-33321387181418466
ENST00000368226PTPRKchr6128505576-ENST00000368250THEMISchr6128031160-342314781091509466
ENST00000368227PTPRKchr6128505576-ENST00000368250THEMISchr6128031160-347415291601560466
ENST00000532331PTPRKchr6128505576-ENST00000368250THEMISchr6128031160-32251280911311406
ENST00000368213PTPRKchr6128505576-ENST00000368250THEMISchr6128031160-33321387181418466
ENST00000368210PTPRKchr6128505576-ENST00000368250THEMISchr6128031160-33651420511451466
ENST00000368215PTPRKchr6128505576-ENST00000368250THEMISchr6128031160-3107116201193397
ENST00000368207PTPRKchr6128505576-ENST00000368250THEMISchr6128031160-33321387181418466

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368226ENST00000368250PTPRKchr6128841404-THEMISchr6128040968-0.676114860.32388514
ENST00000368226ENST00000368248PTPRKchr6128841404-THEMISchr6128040968-0.61756510.38243493
ENST00000368226ENST00000543064PTPRKchr6128841404-THEMISchr6128040968-0.61756510.38243493
ENST00000368226ENST00000537166PTPRKchr6128841404-THEMISchr6128040968-0.61756510.38243493
ENST00000368227ENST00000368250PTPRKchr6128841404-THEMISchr6128040968-0.89031190.10968808
ENST00000368227ENST00000368248PTPRKchr6128841404-THEMISchr6128040968-0.8927660.10723404
ENST00000368227ENST00000543064PTPRKchr6128841404-THEMISchr6128040968-0.8927660.10723404
ENST00000368227ENST00000537166PTPRKchr6128841404-THEMISchr6128040968-0.8927660.10723404
ENST00000532331ENST00000368250PTPRKchr6128841404-THEMISchr6128040968-0.912092450.08790753
ENST00000532331ENST00000368248PTPRKchr6128841404-THEMISchr6128040968-0.846101760.15389821
ENST00000532331ENST00000543064PTPRKchr6128841404-THEMISchr6128040968-0.846101760.15389821
ENST00000532331ENST00000537166PTPRKchr6128841404-THEMISchr6128040968-0.846101760.15389821
ENST00000368213ENST00000368250PTPRKchr6128841404-THEMISchr6128040968-0.831243930.16875602
ENST00000368213ENST00000368248PTPRKchr6128841404-THEMISchr6128040968-0.837787870.16221215
ENST00000368213ENST00000543064PTPRKchr6128841404-THEMISchr6128040968-0.837787870.16221215
ENST00000368213ENST00000537166PTPRKchr6128841404-THEMISchr6128040968-0.837787870.16221215
ENST00000368210ENST00000368250PTPRKchr6128841404-THEMISchr6128040968-0.7907460.20925398
ENST00000368210ENST00000368248PTPRKchr6128841404-THEMISchr6128040968-0.807176950.19282305
ENST00000368210ENST00000543064PTPRKchr6128841404-THEMISchr6128040968-0.807176950.19282305
ENST00000368210ENST00000537166PTPRKchr6128841404-THEMISchr6128040968-0.807176950.19282305
ENST00000368215ENST00000368250PTPRKchr6128841404-THEMISchr6128040968-0.72334890.27665105
ENST00000368215ENST00000368248PTPRKchr6128841404-THEMISchr6128040968-0.72941460.27058542
ENST00000368215ENST00000543064PTPRKchr6128841404-THEMISchr6128040968-0.72941460.27058542
ENST00000368215ENST00000537166PTPRKchr6128841404-THEMISchr6128040968-0.72941460.27058542
ENST00000368207ENST00000368250PTPRKchr6128841404-THEMISchr6128040968-0.831243930.16875602
ENST00000368207ENST00000368248PTPRKchr6128841404-THEMISchr6128040968-0.837787870.16221215
ENST00000368207ENST00000543064PTPRKchr6128841404-THEMISchr6128040968-0.837787870.16221215
ENST00000368207ENST00000537166PTPRKchr6128841404-THEMISchr6128040968-0.837787870.16221215
ENST00000525459ENST00000368250PTPRKchr6128841404-THEMISchr6128040968-0.570425750.42957428
ENST00000525459ENST00000368248PTPRKchr6128841404-THEMISchr6128040968-0.59800680.4019932
ENST00000525459ENST00000543064PTPRKchr6128841404-THEMISchr6128040968-0.59800680.4019932
ENST00000525459ENST00000537166PTPRKchr6128841404-THEMISchr6128040968-0.59800680.4019932
ENST00000368226ENST00000368250PTPRKchr6128505577-THEMISchr6128031161-0.0001466630.9998534
ENST00000368227ENST00000368250PTPRKchr6128505577-THEMISchr6128031161-0.0001481180.9998518
ENST00000532331ENST00000368250PTPRKchr6128505577-THEMISchr6128031161-0.000133240.9998667
ENST00000368213ENST00000368250PTPRKchr6128505577-THEMISchr6128031161-0.0001382940.9998617
ENST00000368210ENST00000368250PTPRKchr6128505577-THEMISchr6128031161-0.0001444740.9998555
ENST00000368215ENST00000368250PTPRKchr6128505577-THEMISchr6128031161-0.0001288930.99987113
ENST00000368207ENST00000368250PTPRKchr6128505577-THEMISchr6128031161-0.0001382940.9998617
ENST00000368226ENST00000368250PTPRKchr6128505576-THEMISchr6128031160-0.0001466630.9998534
ENST00000368227ENST00000368250PTPRKchr6128505576-THEMISchr6128031160-0.0001481180.9998518
ENST00000532331ENST00000368250PTPRKchr6128505576-THEMISchr6128031160-0.000133240.9998667
ENST00000368213ENST00000368250PTPRKchr6128505576-THEMISchr6128031160-0.0001382940.9998617
ENST00000368210ENST00000368250PTPRKchr6128505576-THEMISchr6128031160-0.0001444740.9998555
ENST00000368215ENST00000368250PTPRKchr6128505576-THEMISchr6128031160-0.0001288930.99987113
ENST00000368207ENST00000368250PTPRKchr6128505576-THEMISchr6128031160-0.0001382940.9998617

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>70468_70468_1_PTPRK-THEMIS_PTPRK_chr6_128505576_ENST00000368207_THEMIS_chr6_128031160_ENST00000368250_length(amino acids)=466AA_BP=
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI

--------------------------------------------------------------

>70468_70468_2_PTPRK-THEMIS_PTPRK_chr6_128505576_ENST00000368210_THEMIS_chr6_128031160_ENST00000368250_length(amino acids)=466AA_BP=
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI

--------------------------------------------------------------

>70468_70468_3_PTPRK-THEMIS_PTPRK_chr6_128505576_ENST00000368213_THEMIS_chr6_128031160_ENST00000368250_length(amino acids)=466AA_BP=
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI

--------------------------------------------------------------

>70468_70468_4_PTPRK-THEMIS_PTPRK_chr6_128505576_ENST00000368215_THEMIS_chr6_128031160_ENST00000368250_length(amino acids)=397AA_BP=
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEK
ARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI
AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRC
VTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYE

--------------------------------------------------------------

>70468_70468_5_PTPRK-THEMIS_PTPRK_chr6_128505576_ENST00000368226_THEMIS_chr6_128031160_ENST00000368250_length(amino acids)=466AA_BP=
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI

--------------------------------------------------------------

>70468_70468_6_PTPRK-THEMIS_PTPRK_chr6_128505576_ENST00000368227_THEMIS_chr6_128031160_ENST00000368250_length(amino acids)=466AA_BP=
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI

--------------------------------------------------------------

>70468_70468_7_PTPRK-THEMIS_PTPRK_chr6_128505576_ENST00000532331_THEMIS_chr6_128031160_ENST00000368250_length(amino acids)=406AA_BP=
MLETSPKLGMDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVD
SSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAE
VSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVT
KTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLW

--------------------------------------------------------------

>70468_70468_8_PTPRK-THEMIS_PTPRK_chr6_128505577_ENST00000368207_THEMIS_chr6_128031161_ENST00000368250_length(amino acids)=466AA_BP=
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI

--------------------------------------------------------------

>70468_70468_9_PTPRK-THEMIS_PTPRK_chr6_128505577_ENST00000368210_THEMIS_chr6_128031161_ENST00000368250_length(amino acids)=466AA_BP=
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI

--------------------------------------------------------------

>70468_70468_10_PTPRK-THEMIS_PTPRK_chr6_128505577_ENST00000368213_THEMIS_chr6_128031161_ENST00000368250_length(amino acids)=466AA_BP=
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI

--------------------------------------------------------------

>70468_70468_11_PTPRK-THEMIS_PTPRK_chr6_128505577_ENST00000368215_THEMIS_chr6_128031161_ENST00000368250_length(amino acids)=397AA_BP=
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEK
ARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYI
AIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRC
VTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYE

--------------------------------------------------------------

>70468_70468_12_PTPRK-THEMIS_PTPRK_chr6_128505577_ENST00000368226_THEMIS_chr6_128031161_ENST00000368250_length(amino acids)=466AA_BP=
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI

--------------------------------------------------------------

>70468_70468_13_PTPRK-THEMIS_PTPRK_chr6_128505577_ENST00000368227_THEMIS_chr6_128031161_ENST00000368250_length(amino acids)=466AA_BP=
MPPRPAGDAGDAFAPEVVWRPRRRKKGGRAAVLSPSSPREARPAPPSWISRRSPRQLFAKLLETSPKLGMDTTAAAALPAFVALLLLSPW
PLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYL
LYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRL
GDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREP
PRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI

--------------------------------------------------------------

>70468_70468_14_PTPRK-THEMIS_PTPRK_chr6_128505577_ENST00000532331_THEMIS_chr6_128031161_ENST00000368250_length(amino acids)=406AA_BP=
MLETSPKLGMDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVD
SSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAE
VSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVT
KTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLW

--------------------------------------------------------------

>70468_70468_15_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368207_THEMIS_chr6_128040968_ENST00000368248_length(amino acids)=127AA_BP=69
MSSHRPHPARPGPLLRRGFRGDPPGSSLQSCLKLLPNSAWIRLRRRRCLLLWRSCSSLLGLSWDRPKASSPQRHHVDITKKLHPNQAGLD

--------------------------------------------------------------

>70468_70468_16_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368207_THEMIS_chr6_128040968_ENST00000368250_length(amino acids)=155AA_BP=2
MFLLLLWPHGCSFLSLHPPNHSDYQSVLLNPGQLDLGEVSWLCLRDDAAENWPWADPRRGQGERSKSATKAGSAAAAVVSMPSLGEVSSS

--------------------------------------------------------------

>70468_70468_17_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368207_THEMIS_chr6_128040968_ENST00000537166_length(amino acids)=127AA_BP=69
MSSHRPHPARPGPLLRRGFRGDPPGSSLQSCLKLLPNSAWIRLRRRRCLLLWRSCSSLLGLSWDRPKASSPQRHHVDITKKLHPNQAGLD

--------------------------------------------------------------

>70468_70468_18_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368207_THEMIS_chr6_128040968_ENST00000543064_length(amino acids)=127AA_BP=69
MSSHRPHPARPGPLLRRGFRGDPPGSSLQSCLKLLPNSAWIRLRRRRCLLLWRSCSSLLGLSWDRPKASSPQRHHVDITKKLHPNQAGLD

--------------------------------------------------------------

>70468_70468_19_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368210_THEMIS_chr6_128040968_ENST00000368248_length(amino acids)=133AA_BP=
MIWVKFLGYVYVMTLRRTGLGPIPGEAKERGARAPQKQAAPPPQSYPCRVWEKFQAALQRAAGGIAAKSTTEERAGPRGVRTVRGQPPAR

--------------------------------------------------------------

>70468_70468_20_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368210_THEMIS_chr6_128040968_ENST00000368250_length(amino acids)=166AA_BP=2
MFLLLLWPHGCSFLSLHPPNHSDYQSVLLNPGQLDLGEVSWLCLRDDAAENWPWADPRRGQGERSKSATKAGSAAAAVVSMPSLGEVSSS

--------------------------------------------------------------

>70468_70468_21_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368210_THEMIS_chr6_128040968_ENST00000537166_length(amino acids)=133AA_BP=
MIWVKFLGYVYVMTLRRTGLGPIPGEAKERGARAPQKQAAPPPQSYPCRVWEKFQAALQRAAGGIAAKSTTEERAGPRGVRTVRGQPPAR

--------------------------------------------------------------

>70468_70468_22_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368210_THEMIS_chr6_128040968_ENST00000543064_length(amino acids)=133AA_BP=
MIWVKFLGYVYVMTLRRTGLGPIPGEAKERGARAPQKQAAPPPQSYPCRVWEKFQAALQRAAGGIAAKSTTEERAGPRGVRTVRGQPPAR

--------------------------------------------------------------

>70468_70468_23_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368213_THEMIS_chr6_128040968_ENST00000368248_length(amino acids)=127AA_BP=69
MSSHRPHPARPGPLLRRGFRGDPPGSSLQSCLKLLPNSAWIRLRRRRCLLLWRSCSSLLGLSWDRPKASSPQRHHVDITKKLHPNQAGLD

--------------------------------------------------------------

>70468_70468_24_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368213_THEMIS_chr6_128040968_ENST00000368250_length(amino acids)=155AA_BP=2
MFLLLLWPHGCSFLSLHPPNHSDYQSVLLNPGQLDLGEVSWLCLRDDAAENWPWADPRRGQGERSKSATKAGSAAAAVVSMPSLGEVSSS

--------------------------------------------------------------

>70468_70468_25_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368213_THEMIS_chr6_128040968_ENST00000537166_length(amino acids)=127AA_BP=69
MSSHRPHPARPGPLLRRGFRGDPPGSSLQSCLKLLPNSAWIRLRRRRCLLLWRSCSSLLGLSWDRPKASSPQRHHVDITKKLHPNQAGLD

--------------------------------------------------------------

>70468_70468_26_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368213_THEMIS_chr6_128040968_ENST00000543064_length(amino acids)=127AA_BP=69
MSSHRPHPARPGPLLRRGFRGDPPGSSLQSCLKLLPNSAWIRLRRRRCLLLWRSCSSLLGLSWDRPKASSPQRHHVDITKKLHPNQAGLD

--------------------------------------------------------------

>70468_70468_27_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368215_THEMIS_chr6_128040968_ENST00000368248_length(amino acids)=85AA_BP=27

--------------------------------------------------------------

>70468_70468_28_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368215_THEMIS_chr6_128040968_ENST00000368250_length(amino acids)=85AA_BP=27

--------------------------------------------------------------

>70468_70468_29_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368215_THEMIS_chr6_128040968_ENST00000537166_length(amino acids)=85AA_BP=27

--------------------------------------------------------------

>70468_70468_30_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368215_THEMIS_chr6_128040968_ENST00000543064_length(amino acids)=85AA_BP=27

--------------------------------------------------------------

>70468_70468_31_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368226_THEMIS_chr6_128040968_ENST00000368248_length(amino acids)=152AA_BP=
MIWVKFLGYVYVMTLRRTGLGPIPGEAKERGARAPQKQAAPPPQSYPCRVWEKFQAALQRAAGGIAAKSTTEERAGPRGVRTVRGQPPAR

--------------------------------------------------------------

>70468_70468_32_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368226_THEMIS_chr6_128040968_ENST00000368250_length(amino acids)=186AA_BP=2
MFLLLLWPHGCSFLSLHPPNHSDYQSVLLNPGQLDLGEVSWLCLRDDAAENWPWADPRRGQGERSKSATKAGSAAAAVVSMPSLGEVSSS
FAKSCRGDRREIHDGGAGRASRGEDGERTAARPPFFLLRGRQTTSGAKASPASPAGRGGSSPCSAEAAPVSQELLCSGRDGGGAGGDVAP

--------------------------------------------------------------

>70468_70468_33_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368226_THEMIS_chr6_128040968_ENST00000537166_length(amino acids)=152AA_BP=
MIWVKFLGYVYVMTLRRTGLGPIPGEAKERGARAPQKQAAPPPQSYPCRVWEKFQAALQRAAGGIAAKSTTEERAGPRGVRTVRGQPPAR

--------------------------------------------------------------

>70468_70468_34_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368226_THEMIS_chr6_128040968_ENST00000543064_length(amino acids)=152AA_BP=
MIWVKFLGYVYVMTLRRTGLGPIPGEAKERGARAPQKQAAPPPQSYPCRVWEKFQAALQRAAGGIAAKSTTEERAGPRGVRTVRGQPPAR

--------------------------------------------------------------

>70468_70468_35_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368227_THEMIS_chr6_128040968_ENST00000368248_length(amino acids)=169AA_BP=
MIWVKFLGYVYVMTLRRTGLGPIPGEAKERGARAPQKQAAPPPQSYPCRVWEKFQAALQRAAGGIAAKSTTEERAGPRGVRTVRGQPPAR

--------------------------------------------------------------

>70468_70468_36_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368227_THEMIS_chr6_128040968_ENST00000368250_length(amino acids)=203AA_BP=2
MFLLLLWPHGCSFLSLHPPNHSDYQSVLLNPGQLDLGEVSWLCLRDDAAENWPWADPRRGQGERSKSATKAGSAAAAVVSMPSLGEVSSS
FAKSCRGDRREIHDGGAGRASRGEDGERTAARPPFFLLRGRQTTSGAKASPASPAGRGGSSPCSAEAAPVSQELLCSGRDGGGAGGDVAP

--------------------------------------------------------------

>70468_70468_37_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368227_THEMIS_chr6_128040968_ENST00000537166_length(amino acids)=169AA_BP=
MIWVKFLGYVYVMTLRRTGLGPIPGEAKERGARAPQKQAAPPPQSYPCRVWEKFQAALQRAAGGIAAKSTTEERAGPRGVRTVRGQPPAR

--------------------------------------------------------------

>70468_70468_38_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000368227_THEMIS_chr6_128040968_ENST00000543064_length(amino acids)=169AA_BP=
MIWVKFLGYVYVMTLRRTGLGPIPGEAKERGARAPQKQAAPPPQSYPCRVWEKFQAALQRAAGGIAAKSTTEERAGPRGVRTVRGQPPAR

--------------------------------------------------------------

>70468_70468_39_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000525459_THEMIS_chr6_128040968_ENST00000368248_length(amino acids)=127AA_BP=69
MSSHRPHPARPGPLLRRGFRGDPPGSSLQSCLKLLPNSAWIRLRRRRCLLLWRSCSSLLGLSWDRPKASSPQRHHVDITKKLHPNQAGLD

--------------------------------------------------------------

>70468_70468_40_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000525459_THEMIS_chr6_128040968_ENST00000368250_length(amino acids)=157AA_BP=2
MFLLLLWPHGCSFLSLHPPNHSDYQSVLLNPGQLDLGEVSWLCLRDDAAENWPWADPRRGQGERSKSATKAGSAAAAVVSMPSLGEVSSS

--------------------------------------------------------------

>70468_70468_41_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000525459_THEMIS_chr6_128040968_ENST00000537166_length(amino acids)=127AA_BP=69
MSSHRPHPARPGPLLRRGFRGDPPGSSLQSCLKLLPNSAWIRLRRRRCLLLWRSCSSLLGLSWDRPKASSPQRHHVDITKKLHPNQAGLD

--------------------------------------------------------------

>70468_70468_42_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000525459_THEMIS_chr6_128040968_ENST00000543064_length(amino acids)=127AA_BP=69
MSSHRPHPARPGPLLRRGFRGDPPGSSLQSCLKLLPNSAWIRLRRRRCLLLWRSCSSLLGLSWDRPKASSPQRHHVDITKKLHPNQAGLD

--------------------------------------------------------------

>70468_70468_43_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000532331_THEMIS_chr6_128040968_ENST00000368248_length(amino acids)=127AA_BP=69
LSSHRPHPARPGPLLRRGFRGDPPGSSLQSCLKLLPNSAWIRLRRRRCLLLWRSCSSLLGLSWDRPKASSPQRHHVDITKKLHPNQAGLD

--------------------------------------------------------------

>70468_70468_44_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000532331_THEMIS_chr6_128040968_ENST00000368250_length(amino acids)=127AA_BP=69
LSSHRPHPARPGPLLRRGFRGDPPGSSLQSCLKLLPNSAWIRLRRRRCLLLWRSCSSLLGLSWDRPKASSPQRHHVDITKKLHPNQAGLD

--------------------------------------------------------------

>70468_70468_45_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000532331_THEMIS_chr6_128040968_ENST00000537166_length(amino acids)=127AA_BP=69
LSSHRPHPARPGPLLRRGFRGDPPGSSLQSCLKLLPNSAWIRLRRRRCLLLWRSCSSLLGLSWDRPKASSPQRHHVDITKKLHPNQAGLD

--------------------------------------------------------------

>70468_70468_46_PTPRK-THEMIS_PTPRK_chr6_128841404_ENST00000532331_THEMIS_chr6_128040968_ENST00000543064_length(amino acids)=127AA_BP=69
LSSHRPHPARPGPLLRRGFRGDPPGSSLQSCLKLLPNSAWIRLRRRRCLLLWRSCSSLLGLSWDRPKASSPQRHHVDITKKLHPNQAGLD

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:128385903/chr6:128176333)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRKchr6:128505576chr6:128031160ENST00000368213-731196_281387.33333333333331447.0DomainNote=Ig-like C2-type
HgenePTPRKchr6:128505576chr6:128031160ENST00000368213-731294_389387.33333333333331447.0DomainFibronectin type-III 1
HgenePTPRKchr6:128505576chr6:128031160ENST00000368213-73131_194387.33333333333331447.0DomainMAM
HgenePTPRKchr6:128505576chr6:128031160ENST00000368215-730196_281387.33333333333331440.0DomainNote=Ig-like C2-type
HgenePTPRKchr6:128505576chr6:128031160ENST00000368215-730294_389387.33333333333331440.0DomainFibronectin type-III 1
HgenePTPRKchr6:128505576chr6:128031160ENST00000368215-73031_194387.33333333333331440.0DomainMAM
HgenePTPRKchr6:128505576chr6:128031160ENST00000368226-730196_281387.33333333333331441.0DomainNote=Ig-like C2-type
HgenePTPRKchr6:128505576chr6:128031160ENST00000368226-730294_389387.33333333333331441.0DomainFibronectin type-III 1
HgenePTPRKchr6:128505576chr6:128031160ENST00000368226-73031_194387.33333333333331441.0DomainMAM
HgenePTPRKchr6:128505577chr6:128031161ENST00000368213-731196_281387.33333333333331447.0DomainNote=Ig-like C2-type
HgenePTPRKchr6:128505577chr6:128031161ENST00000368213-731294_389387.33333333333331447.0DomainFibronectin type-III 1
HgenePTPRKchr6:128505577chr6:128031161ENST00000368213-73131_194387.33333333333331447.0DomainMAM
HgenePTPRKchr6:128505577chr6:128031161ENST00000368215-730196_281387.33333333333331440.0DomainNote=Ig-like C2-type
HgenePTPRKchr6:128505577chr6:128031161ENST00000368215-730294_389387.33333333333331440.0DomainFibronectin type-III 1
HgenePTPRKchr6:128505577chr6:128031161ENST00000368215-73031_194387.33333333333331440.0DomainMAM
HgenePTPRKchr6:128505577chr6:128031161ENST00000368226-730196_281387.33333333333331441.0DomainNote=Ig-like C2-type
HgenePTPRKchr6:128505577chr6:128031161ENST00000368226-730294_389387.33333333333331441.0DomainFibronectin type-III 1
HgenePTPRKchr6:128505577chr6:128031161ENST00000368226-73031_194387.33333333333331441.0DomainMAM

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRKchr6:128505576chr6:128031160ENST00000368213-7311173_1435387.33333333333331447.0DomainTyrosine-protein phosphatase 2
HgenePTPRKchr6:128505576chr6:128031160ENST00000368213-731392_488387.33333333333331447.0DomainFibronectin type-III 2
HgenePTPRKchr6:128505576chr6:128031160ENST00000368213-731491_595387.33333333333331447.0DomainFibronectin type-III 3
HgenePTPRKchr6:128505576chr6:128031160ENST00000368213-731597_680387.33333333333331447.0DomainFibronectin type-III 4
HgenePTPRKchr6:128505576chr6:128031160ENST00000368213-731887_1141387.33333333333331447.0DomainTyrosine-protein phosphatase 1
HgenePTPRKchr6:128505576chr6:128031160ENST00000368215-7301173_1435387.33333333333331440.0DomainTyrosine-protein phosphatase 2
HgenePTPRKchr6:128505576chr6:128031160ENST00000368215-730392_488387.33333333333331440.0DomainFibronectin type-III 2
HgenePTPRKchr6:128505576chr6:128031160ENST00000368215-730491_595387.33333333333331440.0DomainFibronectin type-III 3
HgenePTPRKchr6:128505576chr6:128031160ENST00000368215-730597_680387.33333333333331440.0DomainFibronectin type-III 4
HgenePTPRKchr6:128505576chr6:128031160ENST00000368215-730887_1141387.33333333333331440.0DomainTyrosine-protein phosphatase 1
HgenePTPRKchr6:128505576chr6:128031160ENST00000368226-7301173_1435387.33333333333331441.0DomainTyrosine-protein phosphatase 2
HgenePTPRKchr6:128505576chr6:128031160ENST00000368226-730392_488387.33333333333331441.0DomainFibronectin type-III 2
HgenePTPRKchr6:128505576chr6:128031160ENST00000368226-730491_595387.33333333333331441.0DomainFibronectin type-III 3
HgenePTPRKchr6:128505576chr6:128031160ENST00000368226-730597_680387.33333333333331441.0DomainFibronectin type-III 4
HgenePTPRKchr6:128505576chr6:128031160ENST00000368226-730887_1141387.33333333333331441.0DomainTyrosine-protein phosphatase 1
HgenePTPRKchr6:128505577chr6:128031161ENST00000368213-7311173_1435387.33333333333331447.0DomainTyrosine-protein phosphatase 2
HgenePTPRKchr6:128505577chr6:128031161ENST00000368213-731392_488387.33333333333331447.0DomainFibronectin type-III 2
HgenePTPRKchr6:128505577chr6:128031161ENST00000368213-731491_595387.33333333333331447.0DomainFibronectin type-III 3
HgenePTPRKchr6:128505577chr6:128031161ENST00000368213-731597_680387.33333333333331447.0DomainFibronectin type-III 4
HgenePTPRKchr6:128505577chr6:128031161ENST00000368213-731887_1141387.33333333333331447.0DomainTyrosine-protein phosphatase 1
HgenePTPRKchr6:128505577chr6:128031161ENST00000368215-7301173_1435387.33333333333331440.0DomainTyrosine-protein phosphatase 2
HgenePTPRKchr6:128505577chr6:128031161ENST00000368215-730392_488387.33333333333331440.0DomainFibronectin type-III 2
HgenePTPRKchr6:128505577chr6:128031161ENST00000368215-730491_595387.33333333333331440.0DomainFibronectin type-III 3
HgenePTPRKchr6:128505577chr6:128031161ENST00000368215-730597_680387.33333333333331440.0DomainFibronectin type-III 4
HgenePTPRKchr6:128505577chr6:128031161ENST00000368215-730887_1141387.33333333333331440.0DomainTyrosine-protein phosphatase 1
HgenePTPRKchr6:128505577chr6:128031161ENST00000368226-7301173_1435387.33333333333331441.0DomainTyrosine-protein phosphatase 2
HgenePTPRKchr6:128505577chr6:128031161ENST00000368226-730392_488387.33333333333331441.0DomainFibronectin type-III 2
HgenePTPRKchr6:128505577chr6:128031161ENST00000368226-730491_595387.33333333333331441.0DomainFibronectin type-III 3
HgenePTPRKchr6:128505577chr6:128031161ENST00000368226-730597_680387.33333333333331441.0DomainFibronectin type-III 4
HgenePTPRKchr6:128505577chr6:128031161ENST00000368226-730887_1141387.33333333333331441.0DomainTyrosine-protein phosphatase 1
HgenePTPRKchr6:128841404chr6:128040968ENST00000368213-1311173_143533.3333333333333361447.0DomainTyrosine-protein phosphatase 2
HgenePTPRKchr6:128841404chr6:128040968ENST00000368213-131196_28133.3333333333333361447.0DomainNote=Ig-like C2-type
HgenePTPRKchr6:128841404chr6:128040968ENST00000368213-131294_38933.3333333333333361447.0DomainFibronectin type-III 1
HgenePTPRKchr6:128841404chr6:128040968ENST00000368213-13131_19433.3333333333333361447.0DomainMAM
HgenePTPRKchr6:128841404chr6:128040968ENST00000368213-131392_48833.3333333333333361447.0DomainFibronectin type-III 2
HgenePTPRKchr6:128841404chr6:128040968ENST00000368213-131491_59533.3333333333333361447.0DomainFibronectin type-III 3
HgenePTPRKchr6:128841404chr6:128040968ENST00000368213-131597_68033.3333333333333361447.0DomainFibronectin type-III 4
HgenePTPRKchr6:128841404chr6:128040968ENST00000368213-131887_114133.3333333333333361447.0DomainTyrosine-protein phosphatase 1
HgenePTPRKchr6:128841404chr6:128040968ENST00000368215-1301173_143533.3333333333333361440.0DomainTyrosine-protein phosphatase 2
HgenePTPRKchr6:128841404chr6:128040968ENST00000368215-130196_28133.3333333333333361440.0DomainNote=Ig-like C2-type
HgenePTPRKchr6:128841404chr6:128040968ENST00000368215-130294_38933.3333333333333361440.0DomainFibronectin type-III 1
HgenePTPRKchr6:128841404chr6:128040968ENST00000368215-13031_19433.3333333333333361440.0DomainMAM
HgenePTPRKchr6:128841404chr6:128040968ENST00000368215-130392_48833.3333333333333361440.0DomainFibronectin type-III 2
HgenePTPRKchr6:128841404chr6:128040968ENST00000368215-130491_59533.3333333333333361440.0DomainFibronectin type-III 3
HgenePTPRKchr6:128841404chr6:128040968ENST00000368215-130597_68033.3333333333333361440.0DomainFibronectin type-III 4
HgenePTPRKchr6:128841404chr6:128040968ENST00000368215-130887_114133.3333333333333361440.0DomainTyrosine-protein phosphatase 1
HgenePTPRKchr6:128841404chr6:128040968ENST00000368226-1301173_143533.3333333333333361441.0DomainTyrosine-protein phosphatase 2
HgenePTPRKchr6:128841404chr6:128040968ENST00000368226-130196_28133.3333333333333361441.0DomainNote=Ig-like C2-type
HgenePTPRKchr6:128841404chr6:128040968ENST00000368226-130294_38933.3333333333333361441.0DomainFibronectin type-III 1
HgenePTPRKchr6:128841404chr6:128040968ENST00000368226-13031_19433.3333333333333361441.0DomainMAM
HgenePTPRKchr6:128841404chr6:128040968ENST00000368226-130392_48833.3333333333333361441.0DomainFibronectin type-III 2
HgenePTPRKchr6:128841404chr6:128040968ENST00000368226-130491_59533.3333333333333361441.0DomainFibronectin type-III 3
HgenePTPRKchr6:128841404chr6:128040968ENST00000368226-130597_68033.3333333333333361441.0DomainFibronectin type-III 4
HgenePTPRKchr6:128841404chr6:128040968ENST00000368226-130887_114133.3333333333333361441.0DomainTyrosine-protein phosphatase 1
HgenePTPRKchr6:128505576chr6:128031160ENST00000368213-7311082_1088387.33333333333331447.0RegionSubstrate binding
HgenePTPRKchr6:128505576chr6:128031160ENST00000368215-7301082_1088387.33333333333331440.0RegionSubstrate binding
HgenePTPRKchr6:128505576chr6:128031160ENST00000368226-7301082_1088387.33333333333331441.0RegionSubstrate binding
HgenePTPRKchr6:128505577chr6:128031161ENST00000368213-7311082_1088387.33333333333331447.0RegionSubstrate binding
HgenePTPRKchr6:128505577chr6:128031161ENST00000368215-7301082_1088387.33333333333331440.0RegionSubstrate binding
HgenePTPRKchr6:128505577chr6:128031161ENST00000368226-7301082_1088387.33333333333331441.0RegionSubstrate binding
HgenePTPRKchr6:128841404chr6:128040968ENST00000368213-1311082_108833.3333333333333361447.0RegionSubstrate binding
HgenePTPRKchr6:128841404chr6:128040968ENST00000368215-1301082_108833.3333333333333361440.0RegionSubstrate binding
HgenePTPRKchr6:128841404chr6:128040968ENST00000368226-1301082_108833.3333333333333361441.0RegionSubstrate binding
HgenePTPRKchr6:128505576chr6:128031160ENST00000368213-73127_752387.33333333333331447.0Topological domainExtracellular
HgenePTPRKchr6:128505576chr6:128031160ENST00000368213-731775_1439387.33333333333331447.0Topological domainCytoplasmic
HgenePTPRKchr6:128505576chr6:128031160ENST00000368215-73027_752387.33333333333331440.0Topological domainExtracellular
HgenePTPRKchr6:128505576chr6:128031160ENST00000368215-730775_1439387.33333333333331440.0Topological domainCytoplasmic
HgenePTPRKchr6:128505576chr6:128031160ENST00000368226-73027_752387.33333333333331441.0Topological domainExtracellular
HgenePTPRKchr6:128505576chr6:128031160ENST00000368226-730775_1439387.33333333333331441.0Topological domainCytoplasmic
HgenePTPRKchr6:128505577chr6:128031161ENST00000368213-73127_752387.33333333333331447.0Topological domainExtracellular
HgenePTPRKchr6:128505577chr6:128031161ENST00000368213-731775_1439387.33333333333331447.0Topological domainCytoplasmic
HgenePTPRKchr6:128505577chr6:128031161ENST00000368215-73027_752387.33333333333331440.0Topological domainExtracellular
HgenePTPRKchr6:128505577chr6:128031161ENST00000368215-730775_1439387.33333333333331440.0Topological domainCytoplasmic
HgenePTPRKchr6:128505577chr6:128031161ENST00000368226-73027_752387.33333333333331441.0Topological domainExtracellular
HgenePTPRKchr6:128505577chr6:128031161ENST00000368226-730775_1439387.33333333333331441.0Topological domainCytoplasmic
HgenePTPRKchr6:128841404chr6:128040968ENST00000368213-13127_75233.3333333333333361447.0Topological domainExtracellular
HgenePTPRKchr6:128841404chr6:128040968ENST00000368213-131775_143933.3333333333333361447.0Topological domainCytoplasmic
HgenePTPRKchr6:128841404chr6:128040968ENST00000368215-13027_75233.3333333333333361440.0Topological domainExtracellular
HgenePTPRKchr6:128841404chr6:128040968ENST00000368215-130775_143933.3333333333333361440.0Topological domainCytoplasmic
HgenePTPRKchr6:128841404chr6:128040968ENST00000368226-13027_75233.3333333333333361441.0Topological domainExtracellular
HgenePTPRKchr6:128841404chr6:128040968ENST00000368226-130775_143933.3333333333333361441.0Topological domainCytoplasmic
HgenePTPRKchr6:128505576chr6:128031160ENST00000368213-731753_774387.33333333333331447.0TransmembraneHelical
HgenePTPRKchr6:128505576chr6:128031160ENST00000368215-730753_774387.33333333333331440.0TransmembraneHelical
HgenePTPRKchr6:128505576chr6:128031160ENST00000368226-730753_774387.33333333333331441.0TransmembraneHelical
HgenePTPRKchr6:128505577chr6:128031161ENST00000368213-731753_774387.33333333333331447.0TransmembraneHelical
HgenePTPRKchr6:128505577chr6:128031161ENST00000368215-730753_774387.33333333333331440.0TransmembraneHelical
HgenePTPRKchr6:128505577chr6:128031161ENST00000368226-730753_774387.33333333333331441.0TransmembraneHelical
HgenePTPRKchr6:128841404chr6:128040968ENST00000368213-131753_77433.3333333333333361447.0TransmembraneHelical
HgenePTPRKchr6:128841404chr6:128040968ENST00000368215-130753_77433.3333333333333361440.0TransmembraneHelical
HgenePTPRKchr6:128841404chr6:128040968ENST00000368226-130753_77433.3333333333333361441.0TransmembraneHelical
TgeneTHEMISchr6:128505576chr6:128031160ENST00000368248461_259631.3333333333334642.0RegionNote=CABIT 1
TgeneTHEMISchr6:128505576chr6:128031160ENST0000036824846260_518631.3333333333334642.0RegionNote=CABIT 2
TgeneTHEMISchr6:128505576chr6:128031160ENST00000537166461_259596.3333333333334607.0RegionNote=CABIT 1
TgeneTHEMISchr6:128505576chr6:128031160ENST0000053716646260_518596.3333333333334607.0RegionNote=CABIT 2
TgeneTHEMISchr6:128505577chr6:128031161ENST00000368248461_259631.3333333333334642.0RegionNote=CABIT 1
TgeneTHEMISchr6:128505577chr6:128031161ENST0000036824846260_518631.3333333333334642.0RegionNote=CABIT 2
TgeneTHEMISchr6:128505577chr6:128031161ENST00000537166461_259596.3333333333334607.0RegionNote=CABIT 1
TgeneTHEMISchr6:128505577chr6:128031161ENST0000053716646260_518596.3333333333334607.0RegionNote=CABIT 2
TgeneTHEMISchr6:128841404chr6:128040968ENST00000368248361_259586.0642.0RegionNote=CABIT 1
TgeneTHEMISchr6:128841404chr6:128040968ENST0000036824836260_518586.0642.0RegionNote=CABIT 2
TgeneTHEMISchr6:128841404chr6:128040968ENST00000537166361_259551.0607.0RegionNote=CABIT 1
TgeneTHEMISchr6:128841404chr6:128040968ENST0000053716636260_518551.0607.0RegionNote=CABIT 2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PTPRK
THEMIS


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PTPRK-THEMIS


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PTPRK-THEMIS


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource