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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PTPRS-ANGPTL4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PTPRS-ANGPTL4
FusionPDB ID: 70529
FusionGDB2.0 ID: 70529
HgeneTgene
Gene symbol

PTPRS

ANGPTL4

Gene ID

5802

51129

Gene nameprotein tyrosine phosphatase receptor type Sangiopoietin like 4
SynonymsPTPSIGMA|R-PTP-S|R-PTP-sigmaARP4|FIAF|HARP|HFARP|NL2|PGAR|TGQTL|UNQ171|pp1158
Cytomap

19p13.3

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase Sprotein tyrosine phosphatase PTPsigmareceptor-type tyrosine-protein phosphatase sigmaangiopoietin-related protein 4PPARG angiopoietin related proteinfasting-induced adipose factorhepatic angiopoietin-related proteinhepatic fibrinogen/angiopoietin-related proteinperoxisome proliferator-activated receptor (PPAR) gamma induced angiopoie
Modification date2020032220200322
UniProtAcc.

Q9BY76

Ensembl transtripts involved in fusion geneENST idsENST00000262963, ENST00000348075, 
ENST00000353284, ENST00000357368, 
ENST00000372412, ENST00000587303, 
ENST00000588012, ENST00000590509, 
ENST00000592099, ENST00000588552, 
ENST00000301455, ENST00000393962, 
ENST00000541807, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score20 X 19 X 8=30404 X 4 X 3=48
# samples 236
** MAII scorelog2(23/3040*10)=-3.72436555738657
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PTPRS [Title/Abstract] AND ANGPTL4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PTPRS(5286061)-ANGPTL4(8429090), # samples:2
PTPRS(5286061)-ANGPTL4(8430838), # samples:2
Anticipated loss of major functional domain due to fusion event.PTPRS-ANGPTL4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPRS-ANGPTL4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPRS-ANGPTL4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPRS-ANGPTL4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPRS-ANGPTL4 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PTPRS-ANGPTL4 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PTPRS-ANGPTL4 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPRS

GO:0006470

protein dephosphorylation

8524829

HgenePTPRS

GO:0099560

synaptic membrane adhesion

23345436

TgeneANGPTL4

GO:0043066

negative regulation of apoptotic process

10698685

TgeneANGPTL4

GO:0043335

protein unfolding

29899144

TgeneANGPTL4

GO:0051005

negative regulation of lipoprotein lipase activity

19542565|29899144


check buttonFusion gene breakpoints across PTPRS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANGPTL4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-FX-A3NK-01APTPRSchr19

5286061

-ANGPTL4chr19

8429090

+
ChimerDB4SARCTCGA-FX-A3NK-01APTPRSchr19

5286061

-ANGPTL4chr19

8430838

+
ChimerDB4SARCTCGA-FX-A3NKPTPRSchr19

5286060

-ANGPTL4chr19

8430837

+
ChimerDB4SARCTCGA-QC-AA9N-01APTPRSchr19

5286061

-ANGPTL4chr19

8429090

+
ChimerDB4SARCTCGA-QC-AA9N-01APTPRSchr19

5286061

-ANGPTL4chr19

8430838

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000587303PTPRSchr195286060-ENST00000301455ANGPTL4chr198430837+15811911191093324
ENST00000588012PTPRSchr195286060-ENST00000301455ANGPTL4chr198430837+1504114421016324
ENST00000592099PTPRSchr195286060-ENST00000301455ANGPTL4chr198430837+1504114421016324
ENST00000590509PTPRSchr195286060-ENST00000301455ANGPTL4chr198430837+17293392671241324
ENST00000587303PTPRSchr195286061-ENST00000301455ANGPTL4chr198430838+15811911191093324
ENST00000588012PTPRSchr195286061-ENST00000301455ANGPTL4chr198430838+1504114421016324
ENST00000592099PTPRSchr195286061-ENST00000301455ANGPTL4chr198430838+1504114421016324
ENST00000590509PTPRSchr195286061-ENST00000301455ANGPTL4chr198430838+17293392671241324

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000587303ENST00000301455PTPRSchr195286060-ANGPTL4chr198430837+0.0379689370.96203107
ENST00000588012ENST00000301455PTPRSchr195286060-ANGPTL4chr198430837+0.0404598560.9595401
ENST00000592099ENST00000301455PTPRSchr195286060-ANGPTL4chr198430837+0.0404598560.9595401
ENST00000590509ENST00000301455PTPRSchr195286060-ANGPTL4chr198430837+0.0467168880.9532831
ENST00000587303ENST00000301455PTPRSchr195286061-ANGPTL4chr198430838+0.0379689370.96203107
ENST00000588012ENST00000301455PTPRSchr195286061-ANGPTL4chr198430838+0.0404598560.9595401
ENST00000592099ENST00000301455PTPRSchr195286061-ANGPTL4chr198430838+0.0404598560.9595401
ENST00000590509ENST00000301455PTPRSchr195286061-ANGPTL4chr198430838+0.0467168880.9532831

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>70529_70529_1_PTPRS-ANGPTL4_PTPRS_chr19_5286060_ENST00000587303_ANGPTL4_chr19_8430837_ENST00000301455_length(amino acids)=324AA_BP=24
MAWCLWLVPWASLWSCSLEAVQQKTQLKAQNSRIQQLFHKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPV
DPAHNVSRLHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRPWEAYKAGFGDPHGEFWLGLEKV
HSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAYSLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFG

--------------------------------------------------------------

>70529_70529_2_PTPRS-ANGPTL4_PTPRS_chr19_5286060_ENST00000588012_ANGPTL4_chr19_8430837_ENST00000301455_length(amino acids)=324AA_BP=24
MAWCLWLVPWASLWSCSLEAVQQKTQLKAQNSRIQQLFHKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPV
DPAHNVSRLHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRPWEAYKAGFGDPHGEFWLGLEKV
HSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAYSLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFG

--------------------------------------------------------------

>70529_70529_3_PTPRS-ANGPTL4_PTPRS_chr19_5286060_ENST00000590509_ANGPTL4_chr19_8430837_ENST00000301455_length(amino acids)=324AA_BP=24
MAWCLWLVPWASLWSCSLEAVQQKTQLKAQNSRIQQLFHKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPV
DPAHNVSRLHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRPWEAYKAGFGDPHGEFWLGLEKV
HSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAYSLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFG

--------------------------------------------------------------

>70529_70529_4_PTPRS-ANGPTL4_PTPRS_chr19_5286060_ENST00000592099_ANGPTL4_chr19_8430837_ENST00000301455_length(amino acids)=324AA_BP=24
MAWCLWLVPWASLWSCSLEAVQQKTQLKAQNSRIQQLFHKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPV
DPAHNVSRLHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRPWEAYKAGFGDPHGEFWLGLEKV
HSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAYSLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFG

--------------------------------------------------------------

>70529_70529_5_PTPRS-ANGPTL4_PTPRS_chr19_5286061_ENST00000587303_ANGPTL4_chr19_8430838_ENST00000301455_length(amino acids)=324AA_BP=24
MAWCLWLVPWASLWSCSLEAVQQKTQLKAQNSRIQQLFHKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPV
DPAHNVSRLHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRPWEAYKAGFGDPHGEFWLGLEKV
HSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAYSLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFG

--------------------------------------------------------------

>70529_70529_6_PTPRS-ANGPTL4_PTPRS_chr19_5286061_ENST00000588012_ANGPTL4_chr19_8430838_ENST00000301455_length(amino acids)=324AA_BP=24
MAWCLWLVPWASLWSCSLEAVQQKTQLKAQNSRIQQLFHKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPV
DPAHNVSRLHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRPWEAYKAGFGDPHGEFWLGLEKV
HSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAYSLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFG

--------------------------------------------------------------

>70529_70529_7_PTPRS-ANGPTL4_PTPRS_chr19_5286061_ENST00000590509_ANGPTL4_chr19_8430838_ENST00000301455_length(amino acids)=324AA_BP=24
MAWCLWLVPWASLWSCSLEAVQQKTQLKAQNSRIQQLFHKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPV
DPAHNVSRLHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRPWEAYKAGFGDPHGEFWLGLEKV
HSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAYSLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFG

--------------------------------------------------------------

>70529_70529_8_PTPRS-ANGPTL4_PTPRS_chr19_5286061_ENST00000592099_ANGPTL4_chr19_8430838_ENST00000301455_length(amino acids)=324AA_BP=24
MAWCLWLVPWASLWSCSLEAVQQKTQLKAQNSRIQQLFHKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPV
DPAHNVSRLHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRPWEAYKAGFGDPHGEFWLGLEKV
HSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAYSLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:5286061/chr19:8429090)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ANGPTL4

Q9BY76

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism (PubMed:19270337, PubMed:21398697, PubMed:27929370, PubMed:29899144). May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (PubMed:14583458, PubMed:17068295). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (PubMed:17068295). Depending on context, may modulate tumor-related angiogenesis (By similarity). {ECO:0000250|UniProtKB:Q9Z1P8, ECO:0000269|PubMed:14583458, ECO:0000269|PubMed:17068295, ECO:0000269|PubMed:19270337, ECO:0000269|PubMed:21398697, ECO:0000269|PubMed:27929370, ECO:0000269|PubMed:29899144, ECO:0000305|PubMed:29899519}.; FUNCTION: [ANGPTL4 N-terminal chain]: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism (PubMed:19270337, PubMed:21398697, PubMed:27929370, PubMed:29899144). Has higher activity in LPL inactivation than the uncleaved protein (PubMed:19270337, PubMed:21398697). {ECO:0000269|PubMed:19270337, ECO:0000269|PubMed:21398697, ECO:0000269|PubMed:27929370, ECO:0000269|PubMed:29899144}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANGPTL4chr19:5286060chr19:8430837ENST0000030145507179_401106.0407.0DomainFibrinogen C-terminal
TgeneANGPTL4chr19:5286060chr19:8430837ENST0000039396206179_401106.0369.0DomainFibrinogen C-terminal
TgeneANGPTL4chr19:5286061chr19:8430838ENST0000030145507179_401106.0407.0DomainFibrinogen C-terminal
TgeneANGPTL4chr19:5286061chr19:8430838ENST0000039396206179_401106.0369.0DomainFibrinogen C-terminal

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRSchr19:5286060chr19:8430837ENST00000348075-233641_64430.3333333333333321911.0Compositional biasNote=Poly-Pro
HgenePTPRSchr19:5286060chr19:8430837ENST00000353284-229641_64430.3333333333333321502.0Compositional biasNote=Poly-Pro
HgenePTPRSchr19:5286060chr19:8430837ENST00000357368-238641_64430.3333333333333321949.0Compositional biasNote=Poly-Pro
HgenePTPRSchr19:5286060chr19:8430837ENST00000587303-137641_64430.3333333333333321949.0Compositional biasNote=Poly-Pro
HgenePTPRSchr19:5286060chr19:8430837ENST00000588012-132641_64430.3333333333333321911.0Compositional biasNote=Poly-Pro
HgenePTPRSchr19:5286060chr19:8430837ENST00000592099-128641_64430.3333333333333321502.0Compositional biasNote=Poly-Pro
HgenePTPRSchr19:5286061chr19:8430838ENST00000348075-233641_64430.3333333333333321911.0Compositional biasNote=Poly-Pro
HgenePTPRSchr19:5286061chr19:8430838ENST00000353284-229641_64430.3333333333333321502.0Compositional biasNote=Poly-Pro
HgenePTPRSchr19:5286061chr19:8430838ENST00000357368-238641_64430.3333333333333321949.0Compositional biasNote=Poly-Pro
HgenePTPRSchr19:5286061chr19:8430838ENST00000587303-137641_64430.3333333333333321949.0Compositional biasNote=Poly-Pro
HgenePTPRSchr19:5286061chr19:8430838ENST00000588012-132641_64430.3333333333333321911.0Compositional biasNote=Poly-Pro
HgenePTPRSchr19:5286061chr19:8430838ENST00000592099-128641_64430.3333333333333321502.0Compositional biasNote=Poly-Pro
HgenePTPRSchr19:5286060chr19:8430837ENST00000348075-2331036_112030.3333333333333321911.0DomainFibronectin type-III 8
HgenePTPRSchr19:5286060chr19:8430837ENST00000348075-233135_23330.3333333333333321911.0DomainNote=Ig-like C2-type 2
HgenePTPRSchr19:5286060chr19:8430837ENST00000348075-2331393_164830.3333333333333321911.0DomainTyrosine-protein phosphatase 1
HgenePTPRSchr19:5286060chr19:8430837ENST00000348075-2331680_193930.3333333333333321911.0DomainTyrosine-protein phosphatase 2
HgenePTPRSchr19:5286060chr19:8430837ENST00000348075-233245_32730.3333333333333321911.0DomainNote=Ig-like C2-type 3
HgenePTPRSchr19:5286060chr19:8430837ENST00000348075-233334_42430.3333333333333321911.0DomainFibronectin type-III 1
HgenePTPRSchr19:5286060chr19:8430837ENST00000348075-23333_12330.3333333333333321911.0DomainNote=Ig-like C2-type 1
HgenePTPRSchr19:5286060chr19:8430837ENST00000348075-233429_52330.3333333333333321911.0DomainFibronectin type-III 2
HgenePTPRSchr19:5286060chr19:8430837ENST00000348075-233527_61630.3333333333333321911.0DomainFibronectin type-III 3
HgenePTPRSchr19:5286060chr19:8430837ENST00000348075-233621_71830.3333333333333321911.0DomainFibronectin type-III 4
HgenePTPRSchr19:5286060chr19:8430837ENST00000348075-233723_83130.3333333333333321911.0DomainFibronectin type-III 5
HgenePTPRSchr19:5286060chr19:8430837ENST00000348075-233832_93030.3333333333333321911.0DomainFibronectin type-III 6
HgenePTPRSchr19:5286060chr19:8430837ENST00000348075-233931_103330.3333333333333321911.0DomainFibronectin type-III 7
HgenePTPRSchr19:5286060chr19:8430837ENST00000353284-2291036_112030.3333333333333321502.0DomainFibronectin type-III 8
HgenePTPRSchr19:5286060chr19:8430837ENST00000353284-229135_23330.3333333333333321502.0DomainNote=Ig-like C2-type 2
HgenePTPRSchr19:5286060chr19:8430837ENST00000353284-2291393_164830.3333333333333321502.0DomainTyrosine-protein phosphatase 1
HgenePTPRSchr19:5286060chr19:8430837ENST00000353284-2291680_193930.3333333333333321502.0DomainTyrosine-protein phosphatase 2
HgenePTPRSchr19:5286060chr19:8430837ENST00000353284-229245_32730.3333333333333321502.0DomainNote=Ig-like C2-type 3
HgenePTPRSchr19:5286060chr19:8430837ENST00000353284-229334_42430.3333333333333321502.0DomainFibronectin type-III 1
HgenePTPRSchr19:5286060chr19:8430837ENST00000353284-22933_12330.3333333333333321502.0DomainNote=Ig-like C2-type 1
HgenePTPRSchr19:5286060chr19:8430837ENST00000353284-229429_52330.3333333333333321502.0DomainFibronectin type-III 2
HgenePTPRSchr19:5286060chr19:8430837ENST00000353284-229527_61630.3333333333333321502.0DomainFibronectin type-III 3
HgenePTPRSchr19:5286060chr19:8430837ENST00000353284-229621_71830.3333333333333321502.0DomainFibronectin type-III 4
HgenePTPRSchr19:5286060chr19:8430837ENST00000353284-229723_83130.3333333333333321502.0DomainFibronectin type-III 5
HgenePTPRSchr19:5286060chr19:8430837ENST00000353284-229832_93030.3333333333333321502.0DomainFibronectin type-III 6
HgenePTPRSchr19:5286060chr19:8430837ENST00000353284-229931_103330.3333333333333321502.0DomainFibronectin type-III 7
HgenePTPRSchr19:5286060chr19:8430837ENST00000357368-2381036_112030.3333333333333321949.0DomainFibronectin type-III 8
HgenePTPRSchr19:5286060chr19:8430837ENST00000357368-238135_23330.3333333333333321949.0DomainNote=Ig-like C2-type 2
HgenePTPRSchr19:5286060chr19:8430837ENST00000357368-2381393_164830.3333333333333321949.0DomainTyrosine-protein phosphatase 1
HgenePTPRSchr19:5286060chr19:8430837ENST00000357368-2381680_193930.3333333333333321949.0DomainTyrosine-protein phosphatase 2
HgenePTPRSchr19:5286060chr19:8430837ENST00000357368-238245_32730.3333333333333321949.0DomainNote=Ig-like C2-type 3
HgenePTPRSchr19:5286060chr19:8430837ENST00000357368-238334_42430.3333333333333321949.0DomainFibronectin type-III 1
HgenePTPRSchr19:5286060chr19:8430837ENST00000357368-23833_12330.3333333333333321949.0DomainNote=Ig-like C2-type 1
HgenePTPRSchr19:5286060chr19:8430837ENST00000357368-238429_52330.3333333333333321949.0DomainFibronectin type-III 2
HgenePTPRSchr19:5286060chr19:8430837ENST00000357368-238527_61630.3333333333333321949.0DomainFibronectin type-III 3
HgenePTPRSchr19:5286060chr19:8430837ENST00000357368-238621_71830.3333333333333321949.0DomainFibronectin type-III 4
HgenePTPRSchr19:5286060chr19:8430837ENST00000357368-238723_83130.3333333333333321949.0DomainFibronectin type-III 5
HgenePTPRSchr19:5286060chr19:8430837ENST00000357368-238832_93030.3333333333333321949.0DomainFibronectin type-III 6
HgenePTPRSchr19:5286060chr19:8430837ENST00000357368-238931_103330.3333333333333321949.0DomainFibronectin type-III 7
HgenePTPRSchr19:5286060chr19:8430837ENST00000587303-1371036_112030.3333333333333321949.0DomainFibronectin type-III 8
HgenePTPRSchr19:5286060chr19:8430837ENST00000587303-137135_23330.3333333333333321949.0DomainNote=Ig-like C2-type 2
HgenePTPRSchr19:5286060chr19:8430837ENST00000587303-1371393_164830.3333333333333321949.0DomainTyrosine-protein phosphatase 1
HgenePTPRSchr19:5286060chr19:8430837ENST00000587303-1371680_193930.3333333333333321949.0DomainTyrosine-protein phosphatase 2
HgenePTPRSchr19:5286060chr19:8430837ENST00000587303-137245_32730.3333333333333321949.0DomainNote=Ig-like C2-type 3
HgenePTPRSchr19:5286060chr19:8430837ENST00000587303-137334_42430.3333333333333321949.0DomainFibronectin type-III 1
HgenePTPRSchr19:5286060chr19:8430837ENST00000587303-13733_12330.3333333333333321949.0DomainNote=Ig-like C2-type 1
HgenePTPRSchr19:5286060chr19:8430837ENST00000587303-137429_52330.3333333333333321949.0DomainFibronectin type-III 2
HgenePTPRSchr19:5286060chr19:8430837ENST00000587303-137527_61630.3333333333333321949.0DomainFibronectin type-III 3
HgenePTPRSchr19:5286060chr19:8430837ENST00000587303-137621_71830.3333333333333321949.0DomainFibronectin type-III 4
HgenePTPRSchr19:5286060chr19:8430837ENST00000587303-137723_83130.3333333333333321949.0DomainFibronectin type-III 5
HgenePTPRSchr19:5286060chr19:8430837ENST00000587303-137832_93030.3333333333333321949.0DomainFibronectin type-III 6
HgenePTPRSchr19:5286060chr19:8430837ENST00000587303-137931_103330.3333333333333321949.0DomainFibronectin type-III 7
HgenePTPRSchr19:5286060chr19:8430837ENST00000588012-1321036_112030.3333333333333321911.0DomainFibronectin type-III 8
HgenePTPRSchr19:5286060chr19:8430837ENST00000588012-132135_23330.3333333333333321911.0DomainNote=Ig-like C2-type 2
HgenePTPRSchr19:5286060chr19:8430837ENST00000588012-1321393_164830.3333333333333321911.0DomainTyrosine-protein phosphatase 1
HgenePTPRSchr19:5286060chr19:8430837ENST00000588012-1321680_193930.3333333333333321911.0DomainTyrosine-protein phosphatase 2
HgenePTPRSchr19:5286060chr19:8430837ENST00000588012-132245_32730.3333333333333321911.0DomainNote=Ig-like C2-type 3
HgenePTPRSchr19:5286060chr19:8430837ENST00000588012-132334_42430.3333333333333321911.0DomainFibronectin type-III 1
HgenePTPRSchr19:5286060chr19:8430837ENST00000588012-13233_12330.3333333333333321911.0DomainNote=Ig-like C2-type 1
HgenePTPRSchr19:5286060chr19:8430837ENST00000588012-132429_52330.3333333333333321911.0DomainFibronectin type-III 2
HgenePTPRSchr19:5286060chr19:8430837ENST00000588012-132527_61630.3333333333333321911.0DomainFibronectin type-III 3
HgenePTPRSchr19:5286060chr19:8430837ENST00000588012-132621_71830.3333333333333321911.0DomainFibronectin type-III 4
HgenePTPRSchr19:5286060chr19:8430837ENST00000588012-132723_83130.3333333333333321911.0DomainFibronectin type-III 5
HgenePTPRSchr19:5286060chr19:8430837ENST00000588012-132832_93030.3333333333333321911.0DomainFibronectin type-III 6
HgenePTPRSchr19:5286060chr19:8430837ENST00000588012-132931_103330.3333333333333321911.0DomainFibronectin type-III 7
HgenePTPRSchr19:5286060chr19:8430837ENST00000592099-1281036_112030.3333333333333321502.0DomainFibronectin type-III 8
HgenePTPRSchr19:5286060chr19:8430837ENST00000592099-128135_23330.3333333333333321502.0DomainNote=Ig-like C2-type 2
HgenePTPRSchr19:5286060chr19:8430837ENST00000592099-1281393_164830.3333333333333321502.0DomainTyrosine-protein phosphatase 1
HgenePTPRSchr19:5286060chr19:8430837ENST00000592099-1281680_193930.3333333333333321502.0DomainTyrosine-protein phosphatase 2
HgenePTPRSchr19:5286060chr19:8430837ENST00000592099-128245_32730.3333333333333321502.0DomainNote=Ig-like C2-type 3
HgenePTPRSchr19:5286060chr19:8430837ENST00000592099-128334_42430.3333333333333321502.0DomainFibronectin type-III 1
HgenePTPRSchr19:5286060chr19:8430837ENST00000592099-12833_12330.3333333333333321502.0DomainNote=Ig-like C2-type 1
HgenePTPRSchr19:5286060chr19:8430837ENST00000592099-128429_52330.3333333333333321502.0DomainFibronectin type-III 2
HgenePTPRSchr19:5286060chr19:8430837ENST00000592099-128527_61630.3333333333333321502.0DomainFibronectin type-III 3
HgenePTPRSchr19:5286060chr19:8430837ENST00000592099-128621_71830.3333333333333321502.0DomainFibronectin type-III 4
HgenePTPRSchr19:5286060chr19:8430837ENST00000592099-128723_83130.3333333333333321502.0DomainFibronectin type-III 5
HgenePTPRSchr19:5286060chr19:8430837ENST00000592099-128832_93030.3333333333333321502.0DomainFibronectin type-III 6
HgenePTPRSchr19:5286060chr19:8430837ENST00000592099-128931_103330.3333333333333321502.0DomainFibronectin type-III 7
HgenePTPRSchr19:5286061chr19:8430838ENST00000348075-2331036_112030.3333333333333321911.0DomainFibronectin type-III 8
HgenePTPRSchr19:5286061chr19:8430838ENST00000348075-233135_23330.3333333333333321911.0DomainNote=Ig-like C2-type 2
HgenePTPRSchr19:5286061chr19:8430838ENST00000348075-2331393_164830.3333333333333321911.0DomainTyrosine-protein phosphatase 1
HgenePTPRSchr19:5286061chr19:8430838ENST00000348075-2331680_193930.3333333333333321911.0DomainTyrosine-protein phosphatase 2
HgenePTPRSchr19:5286061chr19:8430838ENST00000348075-233245_32730.3333333333333321911.0DomainNote=Ig-like C2-type 3
HgenePTPRSchr19:5286061chr19:8430838ENST00000348075-233334_42430.3333333333333321911.0DomainFibronectin type-III 1
HgenePTPRSchr19:5286061chr19:8430838ENST00000348075-23333_12330.3333333333333321911.0DomainNote=Ig-like C2-type 1
HgenePTPRSchr19:5286061chr19:8430838ENST00000348075-233429_52330.3333333333333321911.0DomainFibronectin type-III 2
HgenePTPRSchr19:5286061chr19:8430838ENST00000348075-233527_61630.3333333333333321911.0DomainFibronectin type-III 3
HgenePTPRSchr19:5286061chr19:8430838ENST00000348075-233621_71830.3333333333333321911.0DomainFibronectin type-III 4
HgenePTPRSchr19:5286061chr19:8430838ENST00000348075-233723_83130.3333333333333321911.0DomainFibronectin type-III 5
HgenePTPRSchr19:5286061chr19:8430838ENST00000348075-233832_93030.3333333333333321911.0DomainFibronectin type-III 6
HgenePTPRSchr19:5286061chr19:8430838ENST00000348075-233931_103330.3333333333333321911.0DomainFibronectin type-III 7
HgenePTPRSchr19:5286061chr19:8430838ENST00000353284-2291036_112030.3333333333333321502.0DomainFibronectin type-III 8
HgenePTPRSchr19:5286061chr19:8430838ENST00000353284-229135_23330.3333333333333321502.0DomainNote=Ig-like C2-type 2
HgenePTPRSchr19:5286061chr19:8430838ENST00000353284-2291393_164830.3333333333333321502.0DomainTyrosine-protein phosphatase 1
HgenePTPRSchr19:5286061chr19:8430838ENST00000353284-2291680_193930.3333333333333321502.0DomainTyrosine-protein phosphatase 2
HgenePTPRSchr19:5286061chr19:8430838ENST00000353284-229245_32730.3333333333333321502.0DomainNote=Ig-like C2-type 3
HgenePTPRSchr19:5286061chr19:8430838ENST00000353284-229334_42430.3333333333333321502.0DomainFibronectin type-III 1
HgenePTPRSchr19:5286061chr19:8430838ENST00000353284-22933_12330.3333333333333321502.0DomainNote=Ig-like C2-type 1
HgenePTPRSchr19:5286061chr19:8430838ENST00000353284-229429_52330.3333333333333321502.0DomainFibronectin type-III 2
HgenePTPRSchr19:5286061chr19:8430838ENST00000353284-229527_61630.3333333333333321502.0DomainFibronectin type-III 3
HgenePTPRSchr19:5286061chr19:8430838ENST00000353284-229621_71830.3333333333333321502.0DomainFibronectin type-III 4
HgenePTPRSchr19:5286061chr19:8430838ENST00000353284-229723_83130.3333333333333321502.0DomainFibronectin type-III 5
HgenePTPRSchr19:5286061chr19:8430838ENST00000353284-229832_93030.3333333333333321502.0DomainFibronectin type-III 6
HgenePTPRSchr19:5286061chr19:8430838ENST00000353284-229931_103330.3333333333333321502.0DomainFibronectin type-III 7
HgenePTPRSchr19:5286061chr19:8430838ENST00000357368-2381036_112030.3333333333333321949.0DomainFibronectin type-III 8
HgenePTPRSchr19:5286061chr19:8430838ENST00000357368-238135_23330.3333333333333321949.0DomainNote=Ig-like C2-type 2
HgenePTPRSchr19:5286061chr19:8430838ENST00000357368-2381393_164830.3333333333333321949.0DomainTyrosine-protein phosphatase 1
HgenePTPRSchr19:5286061chr19:8430838ENST00000357368-2381680_193930.3333333333333321949.0DomainTyrosine-protein phosphatase 2
HgenePTPRSchr19:5286061chr19:8430838ENST00000357368-238245_32730.3333333333333321949.0DomainNote=Ig-like C2-type 3
HgenePTPRSchr19:5286061chr19:8430838ENST00000357368-238334_42430.3333333333333321949.0DomainFibronectin type-III 1
HgenePTPRSchr19:5286061chr19:8430838ENST00000357368-23833_12330.3333333333333321949.0DomainNote=Ig-like C2-type 1
HgenePTPRSchr19:5286061chr19:8430838ENST00000357368-238429_52330.3333333333333321949.0DomainFibronectin type-III 2
HgenePTPRSchr19:5286061chr19:8430838ENST00000357368-238527_61630.3333333333333321949.0DomainFibronectin type-III 3
HgenePTPRSchr19:5286061chr19:8430838ENST00000357368-238621_71830.3333333333333321949.0DomainFibronectin type-III 4
HgenePTPRSchr19:5286061chr19:8430838ENST00000357368-238723_83130.3333333333333321949.0DomainFibronectin type-III 5
HgenePTPRSchr19:5286061chr19:8430838ENST00000357368-238832_93030.3333333333333321949.0DomainFibronectin type-III 6
HgenePTPRSchr19:5286061chr19:8430838ENST00000357368-238931_103330.3333333333333321949.0DomainFibronectin type-III 7
HgenePTPRSchr19:5286061chr19:8430838ENST00000587303-1371036_112030.3333333333333321949.0DomainFibronectin type-III 8
HgenePTPRSchr19:5286061chr19:8430838ENST00000587303-137135_23330.3333333333333321949.0DomainNote=Ig-like C2-type 2
HgenePTPRSchr19:5286061chr19:8430838ENST00000587303-1371393_164830.3333333333333321949.0DomainTyrosine-protein phosphatase 1
HgenePTPRSchr19:5286061chr19:8430838ENST00000587303-1371680_193930.3333333333333321949.0DomainTyrosine-protein phosphatase 2
HgenePTPRSchr19:5286061chr19:8430838ENST00000587303-137245_32730.3333333333333321949.0DomainNote=Ig-like C2-type 3
HgenePTPRSchr19:5286061chr19:8430838ENST00000587303-137334_42430.3333333333333321949.0DomainFibronectin type-III 1
HgenePTPRSchr19:5286061chr19:8430838ENST00000587303-13733_12330.3333333333333321949.0DomainNote=Ig-like C2-type 1
HgenePTPRSchr19:5286061chr19:8430838ENST00000587303-137429_52330.3333333333333321949.0DomainFibronectin type-III 2
HgenePTPRSchr19:5286061chr19:8430838ENST00000587303-137527_61630.3333333333333321949.0DomainFibronectin type-III 3
HgenePTPRSchr19:5286061chr19:8430838ENST00000587303-137621_71830.3333333333333321949.0DomainFibronectin type-III 4
HgenePTPRSchr19:5286061chr19:8430838ENST00000587303-137723_83130.3333333333333321949.0DomainFibronectin type-III 5
HgenePTPRSchr19:5286061chr19:8430838ENST00000587303-137832_93030.3333333333333321949.0DomainFibronectin type-III 6
HgenePTPRSchr19:5286061chr19:8430838ENST00000587303-137931_103330.3333333333333321949.0DomainFibronectin type-III 7
HgenePTPRSchr19:5286061chr19:8430838ENST00000588012-1321036_112030.3333333333333321911.0DomainFibronectin type-III 8
HgenePTPRSchr19:5286061chr19:8430838ENST00000588012-132135_23330.3333333333333321911.0DomainNote=Ig-like C2-type 2
HgenePTPRSchr19:5286061chr19:8430838ENST00000588012-1321393_164830.3333333333333321911.0DomainTyrosine-protein phosphatase 1
HgenePTPRSchr19:5286061chr19:8430838ENST00000588012-1321680_193930.3333333333333321911.0DomainTyrosine-protein phosphatase 2
HgenePTPRSchr19:5286061chr19:8430838ENST00000588012-132245_32730.3333333333333321911.0DomainNote=Ig-like C2-type 3
HgenePTPRSchr19:5286061chr19:8430838ENST00000588012-132334_42430.3333333333333321911.0DomainFibronectin type-III 1
HgenePTPRSchr19:5286061chr19:8430838ENST00000588012-13233_12330.3333333333333321911.0DomainNote=Ig-like C2-type 1
HgenePTPRSchr19:5286061chr19:8430838ENST00000588012-132429_52330.3333333333333321911.0DomainFibronectin type-III 2
HgenePTPRSchr19:5286061chr19:8430838ENST00000588012-132527_61630.3333333333333321911.0DomainFibronectin type-III 3
HgenePTPRSchr19:5286061chr19:8430838ENST00000588012-132621_71830.3333333333333321911.0DomainFibronectin type-III 4
HgenePTPRSchr19:5286061chr19:8430838ENST00000588012-132723_83130.3333333333333321911.0DomainFibronectin type-III 5
HgenePTPRSchr19:5286061chr19:8430838ENST00000588012-132832_93030.3333333333333321911.0DomainFibronectin type-III 6
HgenePTPRSchr19:5286061chr19:8430838ENST00000588012-132931_103330.3333333333333321911.0DomainFibronectin type-III 7
HgenePTPRSchr19:5286061chr19:8430838ENST00000592099-1281036_112030.3333333333333321502.0DomainFibronectin type-III 8
HgenePTPRSchr19:5286061chr19:8430838ENST00000592099-128135_23330.3333333333333321502.0DomainNote=Ig-like C2-type 2
HgenePTPRSchr19:5286061chr19:8430838ENST00000592099-1281393_164830.3333333333333321502.0DomainTyrosine-protein phosphatase 1
HgenePTPRSchr19:5286061chr19:8430838ENST00000592099-1281680_193930.3333333333333321502.0DomainTyrosine-protein phosphatase 2
HgenePTPRSchr19:5286061chr19:8430838ENST00000592099-128245_32730.3333333333333321502.0DomainNote=Ig-like C2-type 3
HgenePTPRSchr19:5286061chr19:8430838ENST00000592099-128334_42430.3333333333333321502.0DomainFibronectin type-III 1
HgenePTPRSchr19:5286061chr19:8430838ENST00000592099-12833_12330.3333333333333321502.0DomainNote=Ig-like C2-type 1
HgenePTPRSchr19:5286061chr19:8430838ENST00000592099-128429_52330.3333333333333321502.0DomainFibronectin type-III 2
HgenePTPRSchr19:5286061chr19:8430838ENST00000592099-128527_61630.3333333333333321502.0DomainFibronectin type-III 3
HgenePTPRSchr19:5286061chr19:8430838ENST00000592099-128621_71830.3333333333333321502.0DomainFibronectin type-III 4
HgenePTPRSchr19:5286061chr19:8430838ENST00000592099-128723_83130.3333333333333321502.0DomainFibronectin type-III 5
HgenePTPRSchr19:5286061chr19:8430838ENST00000592099-128832_93030.3333333333333321502.0DomainFibronectin type-III 6
HgenePTPRSchr19:5286061chr19:8430838ENST00000592099-128931_103330.3333333333333321502.0DomainFibronectin type-III 7
HgenePTPRSchr19:5286060chr19:8430837ENST00000348075-2331589_159530.3333333333333321911.0RegionSubstrate binding
HgenePTPRSchr19:5286060chr19:8430837ENST00000348075-23368_7230.3333333333333321911.0RegionImportant for binding to glycosaminoglycan chains
HgenePTPRSchr19:5286060chr19:8430837ENST00000353284-2291589_159530.3333333333333321502.0RegionSubstrate binding
HgenePTPRSchr19:5286060chr19:8430837ENST00000353284-22968_7230.3333333333333321502.0RegionImportant for binding to glycosaminoglycan chains
HgenePTPRSchr19:5286060chr19:8430837ENST00000357368-2381589_159530.3333333333333321949.0RegionSubstrate binding
HgenePTPRSchr19:5286060chr19:8430837ENST00000357368-23868_7230.3333333333333321949.0RegionImportant for binding to glycosaminoglycan chains
HgenePTPRSchr19:5286060chr19:8430837ENST00000587303-1371589_159530.3333333333333321949.0RegionSubstrate binding
HgenePTPRSchr19:5286060chr19:8430837ENST00000587303-13768_7230.3333333333333321949.0RegionImportant for binding to glycosaminoglycan chains
HgenePTPRSchr19:5286060chr19:8430837ENST00000588012-1321589_159530.3333333333333321911.0RegionSubstrate binding
HgenePTPRSchr19:5286060chr19:8430837ENST00000588012-13268_7230.3333333333333321911.0RegionImportant for binding to glycosaminoglycan chains
HgenePTPRSchr19:5286060chr19:8430837ENST00000592099-1281589_159530.3333333333333321502.0RegionSubstrate binding
HgenePTPRSchr19:5286060chr19:8430837ENST00000592099-12868_7230.3333333333333321502.0RegionImportant for binding to glycosaminoglycan chains
HgenePTPRSchr19:5286061chr19:8430838ENST00000348075-2331589_159530.3333333333333321911.0RegionSubstrate binding
HgenePTPRSchr19:5286061chr19:8430838ENST00000348075-23368_7230.3333333333333321911.0RegionImportant for binding to glycosaminoglycan chains
HgenePTPRSchr19:5286061chr19:8430838ENST00000353284-2291589_159530.3333333333333321502.0RegionSubstrate binding
HgenePTPRSchr19:5286061chr19:8430838ENST00000353284-22968_7230.3333333333333321502.0RegionImportant for binding to glycosaminoglycan chains
HgenePTPRSchr19:5286061chr19:8430838ENST00000357368-2381589_159530.3333333333333321949.0RegionSubstrate binding
HgenePTPRSchr19:5286061chr19:8430838ENST00000357368-23868_7230.3333333333333321949.0RegionImportant for binding to glycosaminoglycan chains
HgenePTPRSchr19:5286061chr19:8430838ENST00000587303-1371589_159530.3333333333333321949.0RegionSubstrate binding
HgenePTPRSchr19:5286061chr19:8430838ENST00000587303-13768_7230.3333333333333321949.0RegionImportant for binding to glycosaminoglycan chains
HgenePTPRSchr19:5286061chr19:8430838ENST00000588012-1321589_159530.3333333333333321911.0RegionSubstrate binding
HgenePTPRSchr19:5286061chr19:8430838ENST00000588012-13268_7230.3333333333333321911.0RegionImportant for binding to glycosaminoglycan chains
HgenePTPRSchr19:5286061chr19:8430838ENST00000592099-1281589_159530.3333333333333321502.0RegionSubstrate binding
HgenePTPRSchr19:5286061chr19:8430838ENST00000592099-12868_7230.3333333333333321502.0RegionImportant for binding to glycosaminoglycan chains
HgenePTPRSchr19:5286060chr19:8430837ENST00000348075-2331304_194830.3333333333333321911.0Topological domainCytoplasmic
HgenePTPRSchr19:5286060chr19:8430837ENST00000348075-23330_128230.3333333333333321911.0Topological domainExtracellular
HgenePTPRSchr19:5286060chr19:8430837ENST00000353284-2291304_194830.3333333333333321502.0Topological domainCytoplasmic
HgenePTPRSchr19:5286060chr19:8430837ENST00000353284-22930_128230.3333333333333321502.0Topological domainExtracellular
HgenePTPRSchr19:5286060chr19:8430837ENST00000357368-2381304_194830.3333333333333321949.0Topological domainCytoplasmic
HgenePTPRSchr19:5286060chr19:8430837ENST00000357368-23830_128230.3333333333333321949.0Topological domainExtracellular
HgenePTPRSchr19:5286060chr19:8430837ENST00000587303-1371304_194830.3333333333333321949.0Topological domainCytoplasmic
HgenePTPRSchr19:5286060chr19:8430837ENST00000587303-13730_128230.3333333333333321949.0Topological domainExtracellular
HgenePTPRSchr19:5286060chr19:8430837ENST00000588012-1321304_194830.3333333333333321911.0Topological domainCytoplasmic
HgenePTPRSchr19:5286060chr19:8430837ENST00000588012-13230_128230.3333333333333321911.0Topological domainExtracellular
HgenePTPRSchr19:5286060chr19:8430837ENST00000592099-1281304_194830.3333333333333321502.0Topological domainCytoplasmic
HgenePTPRSchr19:5286060chr19:8430837ENST00000592099-12830_128230.3333333333333321502.0Topological domainExtracellular
HgenePTPRSchr19:5286061chr19:8430838ENST00000348075-2331304_194830.3333333333333321911.0Topological domainCytoplasmic
HgenePTPRSchr19:5286061chr19:8430838ENST00000348075-23330_128230.3333333333333321911.0Topological domainExtracellular
HgenePTPRSchr19:5286061chr19:8430838ENST00000353284-2291304_194830.3333333333333321502.0Topological domainCytoplasmic
HgenePTPRSchr19:5286061chr19:8430838ENST00000353284-22930_128230.3333333333333321502.0Topological domainExtracellular
HgenePTPRSchr19:5286061chr19:8430838ENST00000357368-2381304_194830.3333333333333321949.0Topological domainCytoplasmic
HgenePTPRSchr19:5286061chr19:8430838ENST00000357368-23830_128230.3333333333333321949.0Topological domainExtracellular
HgenePTPRSchr19:5286061chr19:8430838ENST00000587303-1371304_194830.3333333333333321949.0Topological domainCytoplasmic
HgenePTPRSchr19:5286061chr19:8430838ENST00000587303-13730_128230.3333333333333321949.0Topological domainExtracellular
HgenePTPRSchr19:5286061chr19:8430838ENST00000588012-1321304_194830.3333333333333321911.0Topological domainCytoplasmic
HgenePTPRSchr19:5286061chr19:8430838ENST00000588012-13230_128230.3333333333333321911.0Topological domainExtracellular
HgenePTPRSchr19:5286061chr19:8430838ENST00000592099-1281304_194830.3333333333333321502.0Topological domainCytoplasmic
HgenePTPRSchr19:5286061chr19:8430838ENST00000592099-12830_128230.3333333333333321502.0Topological domainExtracellular
HgenePTPRSchr19:5286060chr19:8430837ENST00000348075-2331283_130330.3333333333333321911.0TransmembraneHelical
HgenePTPRSchr19:5286060chr19:8430837ENST00000353284-2291283_130330.3333333333333321502.0TransmembraneHelical
HgenePTPRSchr19:5286060chr19:8430837ENST00000357368-2381283_130330.3333333333333321949.0TransmembraneHelical
HgenePTPRSchr19:5286060chr19:8430837ENST00000587303-1371283_130330.3333333333333321949.0TransmembraneHelical
HgenePTPRSchr19:5286060chr19:8430837ENST00000588012-1321283_130330.3333333333333321911.0TransmembraneHelical
HgenePTPRSchr19:5286060chr19:8430837ENST00000592099-1281283_130330.3333333333333321502.0TransmembraneHelical
HgenePTPRSchr19:5286061chr19:8430838ENST00000348075-2331283_130330.3333333333333321911.0TransmembraneHelical
HgenePTPRSchr19:5286061chr19:8430838ENST00000353284-2291283_130330.3333333333333321502.0TransmembraneHelical
HgenePTPRSchr19:5286061chr19:8430838ENST00000357368-2381283_130330.3333333333333321949.0TransmembraneHelical
HgenePTPRSchr19:5286061chr19:8430838ENST00000587303-1371283_130330.3333333333333321949.0TransmembraneHelical
HgenePTPRSchr19:5286061chr19:8430838ENST00000588012-1321283_130330.3333333333333321911.0TransmembraneHelical
HgenePTPRSchr19:5286061chr19:8430838ENST00000592099-1281283_130330.3333333333333321502.0TransmembraneHelical
TgeneANGPTL4chr19:5286060chr19:8430837ENST0000030145507100_143106.0407.0Coiled coilOntology_term=ECO:0000255
TgeneANGPTL4chr19:5286060chr19:8430837ENST0000039396206100_143106.0369.0Coiled coilOntology_term=ECO:0000255
TgeneANGPTL4chr19:5286061chr19:8430838ENST0000030145507100_143106.0407.0Coiled coilOntology_term=ECO:0000255
TgeneANGPTL4chr19:5286061chr19:8430838ENST0000039396206100_143106.0369.0Coiled coilOntology_term=ECO:0000255


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>600_PTPRS_5286061_ANGPTL4_8430838_ranked_0.pdbPTPRS52860615286061ENST00000301455ANGPTL4chr198430838+
MAWCLWLVPWASLWSCSLEAVQQKTQLKAQNSRIQQLFHKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPV
DPAHNVSRLHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRPWEAYKAGFGDPHGEFWLGLEKV
HSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAYSLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFG
324


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
PTPRS_pLDDT.png
all structure
all structure
ANGPTL4_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PTPRS
ANGPTL4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PTPRS-ANGPTL4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PTPRS-ANGPTL4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource