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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PXMP2-DDB2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PXMP2-DDB2
	FusionPDB ID: 70900
	FusionGDB2.0 ID: 70900
		Hgene	Tgene
	Gene symbol	PXMP2	DDB2
	Gene ID	5827	1643
	Gene name	peroxisomal membrane protein 2	damage specific DNA binding protein 2
	Synonyms	MPV17L3\|PMP22	DDBB\|UV-DDB2\|XPE
	Cytomap	12q24.33	11p11.2
	Type of gene	protein-coding	protein-coding
	Description	peroxisomal membrane protein 222 kDa peroxisomal membrane proteinperoxisomal membrane protein 2, 22kDa	DNA damage-binding protein 2DDB p48 subunitUV-DDB 2UV-damaged DNA-binding protein 2damage-specific DNA binding protein 2, 48kDaxeroderma pigmentosum group E protein
	Modification date	20200313	20200327
	UniProtAcc	.	Q92466
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000317479, ENST00000428960, ENST00000539093, ENST00000545677, ENST00000543589,	ENST00000378601, ENST00000256996, ENST00000378600, ENST00000378603,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 4 X 5=160	12 X 6 X 7=504
	# samples	8	11
	** MAII score	log2(8/160*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/504*10)=-2.19592020997526 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PXMP2 [Title/Abstract] AND DDB2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PXMP2(133277955)-DDB2(47259387), # samples:2
Anticipated loss of major functional domain due to fusion event.	PXMP2-DDB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PXMP2-DDB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PXMP2-DDB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PXMP2-DDB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PXMP2-DDB2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. PXMP2-DDB2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. PXMP2-DDB2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	DDB2	GO:0000209	protein polyubiquitination	12732143
Tgene	DDB2	GO:0009411	response to UV	12732143
Tgene	DDB2	GO:0035518	histone H2A monoubiquitination	22334663
Tgene	DDB2	GO:0051865	protein autoubiquitination	12732143
Tgene	DDB2	GO:0070914	UV-damage excision repair	22334663

Fusion gene breakpoints across PXMP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DDB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	COAD	TCGA-AA-3850	PXMP2	chr12	133277955	+	DDB2	chr11	47259387	+
ChimerDB4	OV	TCGA-29-1697	PXMP2	chr12	133277955	+	DDB2	chr11	47259387	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000317479	PXMP2	chr12	133277955	+	ENST00000378600	DDB2	chr11	47259387	+	1212	584	20	844	274
ENST00000317479	PXMP2	chr12	133277955	+	ENST00000378603	DDB2	chr11	47259387	+	1212	584	20	844	274
ENST00000317479	PXMP2	chr12	133277955	+	ENST00000256996	DDB2	chr11	47259387	+	1212	584	20	844	274
ENST00000428960	PXMP2	chr12	133277955	+	ENST00000378600	DDB2	chr11	47259387	+	974	346	25	606	193
ENST00000428960	PXMP2	chr12	133277955	+	ENST00000378603	DDB2	chr11	47259387	+	974	346	25	606	193
ENST00000428960	PXMP2	chr12	133277955	+	ENST00000256996	DDB2	chr11	47259387	+	974	346	25	606	193

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000317479	ENST00000378600	PXMP2	chr12	133277955	+	DDB2	chr11	47259387	+	0.002865458	0.99713457
ENST00000317479	ENST00000378603	PXMP2	chr12	133277955	+	DDB2	chr11	47259387	+	0.002865458	0.99713457
ENST00000317479	ENST00000256996	PXMP2	chr12	133277955	+	DDB2	chr11	47259387	+	0.002865458	0.99713457
ENST00000428960	ENST00000378600	PXMP2	chr12	133277955	+	DDB2	chr11	47259387	+	0.010373712	0.9896263
ENST00000428960	ENST00000378603	PXMP2	chr12	133277955	+	DDB2	chr11	47259387	+	0.010373712	0.9896263
ENST00000428960	ENST00000256996	PXMP2	chr12	133277955	+	DDB2	chr11	47259387	+	0.010373712	0.9896263

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>70900_70900_1_PXMP2-DDB2_PXMP2_chr12_133277955_ENST00000317479_DDB2_chr11_47259387_ENST00000256996_length(amino acids)=274AA_BP=188
MRWGRCPRRHGAGEAMAPAASRLRAEAGLGALPRRALAQYLLFLRLYPVLTKAATSGILSALGNFLAQMIEKKRKKENSRSLDVGGPLRY
AVYGFFFTGPLSHFFYFFMEHWIPPEVPLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNWRVWTPLQFI
NINYVPLKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWSQEEA

--------------------------------------------------------------

>70900_70900_2_PXMP2-DDB2_PXMP2_chr12_133277955_ENST00000317479_DDB2_chr11_47259387_ENST00000378600_length(amino acids)=274AA_BP=188
MRWGRCPRRHGAGEAMAPAASRLRAEAGLGALPRRALAQYLLFLRLYPVLTKAATSGILSALGNFLAQMIEKKRKKENSRSLDVGGPLRY
AVYGFFFTGPLSHFFYFFMEHWIPPEVPLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNWRVWTPLQFI
NINYVPLKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWSQEEA

--------------------------------------------------------------

>70900_70900_3_PXMP2-DDB2_PXMP2_chr12_133277955_ENST00000317479_DDB2_chr11_47259387_ENST00000378603_length(amino acids)=274AA_BP=188
MRWGRCPRRHGAGEAMAPAASRLRAEAGLGALPRRALAQYLLFLRLYPVLTKAATSGILSALGNFLAQMIEKKRKKENSRSLDVGGPLRY
AVYGFFFTGPLSHFFYFFMEHWIPPEVPLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNWRVWTPLQFI
NINYVPLKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWSQEEA

--------------------------------------------------------------

>70900_70900_4_PXMP2-DDB2_PXMP2_chr12_133277955_ENST00000428960_DDB2_chr11_47259387_ENST00000256996_length(amino acids)=193AA_BP=107
MDVGGPLRYAVYGFFFTGPLSHFFYFFMEHWIPPEVPLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNW
RVWTPLQFININYVPLKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYH

--------------------------------------------------------------

>70900_70900_5_PXMP2-DDB2_PXMP2_chr12_133277955_ENST00000428960_DDB2_chr11_47259387_ENST00000378600_length(amino acids)=193AA_BP=107
MDVGGPLRYAVYGFFFTGPLSHFFYFFMEHWIPPEVPLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNW
RVWTPLQFININYVPLKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYH

--------------------------------------------------------------

>70900_70900_6_PXMP2-DDB2_PXMP2_chr12_133277955_ENST00000428960_DDB2_chr11_47259387_ENST00000378603_length(amino acids)=193AA_BP=107
MDVGGPLRYAVYGFFFTGPLSHFFYFFMEHWIPPEVPLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNW
RVWTPLQFININYVPLKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYH

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:133277955/chr11:47259387)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	DDB2 Q92466
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:9892649, PubMed:12732143, PubMed:15882621, PubMed:16473935, PubMed:18593899). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:16260596, PubMed:12944386, PubMed:14751237). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:16260596, PubMed:12944386). Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1) (PubMed:12732143, PubMed:15882621, PubMed:16473935, PubMed:18593899, PubMed:26572825). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (PubMed:16678110, PubMed:16473935). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (PubMed:16678110, PubMed:16473935). The DDB2-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (PubMed:15882621). The DDB2-CUL4-ROC1 complex also ubiquitinates KAT7/HBO1 in response to DNA damage, leading to its degradation: recognizes KAT7/HBO1 following phosphorylation by ATR (PubMed:26572825). {ECO:0000269\|PubMed:10882109, ECO:0000269\|PubMed:11278856, ECO:0000269\|PubMed:11705987, ECO:0000269\|PubMed:12732143, ECO:0000269\|PubMed:12944386, ECO:0000269\|PubMed:14751237, ECO:0000269\|PubMed:15882621, ECO:0000269\|PubMed:16260596, ECO:0000269\|PubMed:16473935, ECO:0000269\|PubMed:16678110, ECO:0000269\|PubMed:18593899, ECO:0000269\|PubMed:26572825, ECO:0000269\|PubMed:9892649}.; FUNCTION: [Isoform D1]: Inhibits UV-damaged DNA repair. {ECO:0000269\|PubMed:14751237}.; FUNCTION: [Isoform D2]: Inhibits UV-damaged DNA repair. {ECO:0000269\|PubMed:14751237}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PXMP2

chr12:133277955

chr11:47259387

ENST00000317479

136_173

173.0

196.0

Topological domain

Peroxisomal

Hgene

PXMP2

chr12:133277955

chr11:47259387

ENST00000317479

1_30

173.0

196.0

Topological domain

Cytoplasmic

Hgene

PXMP2

chr12:133277955

chr11:47259387

ENST00000317479

52_75

173.0

196.0

Topological domain

Peroxisomal

Hgene

PXMP2

chr12:133277955

chr11:47259387

ENST00000317479

97_114

173.0

196.0

Topological domain

Cytoplasmic

Hgene

PXMP2

chr12:133277955

chr11:47259387

ENST00000317479

115_135

173.0

196.0

Transmembrane

Helical

Hgene

PXMP2

chr12:133277955

chr11:47259387

ENST00000317479

31_51

173.0

196.0

Transmembrane

Helical

Hgene

PXMP2

chr12:133277955

chr11:47259387

ENST00000317479

76_96

173.0

196.0

Transmembrane

Helical

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378600

256_274

152.0

239.0

Motif

Note=DWD box

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378600

334_336

152.0

239.0

Region

Note=Photolesion recognition

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378601

334_336

281.6666666666667

237.33333333333334

Region

Note=Photolesion recognition

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378603

334_336

277.0

364.0

Region

Note=Photolesion recognition

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000256996

343_386

341.0

428.0

Repeat

WD 6

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000256996

396_420

341.0

428.0

Repeat

WD 7

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378600

159_194

152.0

239.0

Repeat

WD 2

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378600

203_238

152.0

239.0

Repeat

WD 3

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378600

244_287

152.0

239.0

Repeat

WD 4

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378600

290_329

152.0

239.0

Repeat

WD 5

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378600

343_386

152.0

239.0

Repeat

WD 6

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378600

396_420

152.0

239.0

Repeat

WD 7

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378601

290_329

281.6666666666667

237.33333333333334

Repeat

WD 5

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378601

343_386

281.6666666666667

237.33333333333334

Repeat

WD 6

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378601

396_420

281.6666666666667

237.33333333333334

Repeat

WD 7

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378603

290_329

277.0

364.0

Repeat

WD 5

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378603

343_386

277.0

364.0

Repeat

WD 6

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378603

396_420

277.0

364.0

Repeat

WD 7

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PXMP2

chr12:133277955

chr11:47259387

ENST00000317479

174_194

173.0

196.0

Transmembrane

Helical

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000256996

256_274

341.0

428.0

Motif

Note=DWD box

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378601

256_274

281.6666666666667

237.33333333333334

Motif

Note=DWD box

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378603

256_274

277.0

364.0

Motif

Note=DWD box

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000256996

334_336

341.0

428.0

Region

Note=Photolesion recognition

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000256996

116_151

341.0

428.0

Repeat

WD 1

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000256996

159_194

341.0

428.0

Repeat

WD 2

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000256996

203_238

341.0

428.0

Repeat

WD 3

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000256996

244_287

341.0

428.0

Repeat

WD 4

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000256996

290_329

341.0

428.0

Repeat

WD 5

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378600

116_151

152.0

239.0

Repeat

WD 1

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378601

116_151

281.6666666666667

237.33333333333334

Repeat

WD 1

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378601

159_194

281.6666666666667

237.33333333333334

Repeat

WD 2

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378601

203_238

281.6666666666667

237.33333333333334

Repeat

WD 3

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378601

244_287

281.6666666666667

237.33333333333334

Repeat

WD 4

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378603

116_151

277.0

364.0

Repeat

WD 1

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378603

159_194

277.0

364.0

Repeat

WD 2

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378603

203_238

277.0

364.0

Repeat

WD 3

Tgene

DDB2

chr12:133277955

chr11:47259387

ENST00000378603

244_287

277.0

364.0

Repeat

WD 4

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>474_PXMP2_133277955_DDB2_47259387_ranked_0.pdb	PXMP2	133277955	133277955	ENST00000256996	DDB2	chr11	47259387	+	MRWGRCPRRHGAGEAMAPAASRLRAEAGLGALPRRALAQYLLFLRLYPVLTKAATSGILSALGNFLAQMIEKKRKKENSRSLDVGGPLRY AVYGFFFTGPLSHFFYFFMEHWIPPEVPLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNWRVWTPLQFI NINYVPLKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWSQEEA	274

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

PXMP2_pLDDT.png

DDB2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PXMP2
DDB2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to PXMP2-DDB2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to PXMP2-DDB2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source