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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:RAB11FIP1-HTRA4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RAB11FIP1-HTRA4
FusionPDB ID: 71138
FusionGDB2.0 ID: 71138
HgeneTgene
Gene symbol

RAB11FIP1

HTRA4

Gene ID

80223

203100

Gene nameRAB11 family interacting protein 1HtrA serine peptidase 4
SynonymsNOEL1A|RCP|rab11-FIP1-
Cytomap

8p11.23

8p11.22

Type of geneprotein-codingprotein-coding
Descriptionrab11 family-interacting protein 1RAB11 coupling proteinRAB11 family interacting protein 1 (class I)Rab effector proteinRab-interacting recycling proteinserine protease HTRA4high-temperature requirement factor A4probable serine protease HTRA4
Modification date2020031320200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000523182, ENST00000522727, 
ENST00000287263, ENST00000330843, 
ENST00000524118, 		ENST00000302495, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 14 X 4=5605 X 7 X 5=175
# samples 127
** MAII scorelog2(12/560*10)=-2.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RAB11FIP1 [Title/Abstract] AND HTRA4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RAB11FIP1(37727938)-HTRA4(38836734), # samples:3
Anticipated loss of major functional domain due to fusion event.RAB11FIP1-HTRA4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RAB11FIP1-HTRA4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RAB11FIP1-HTRA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RAB11FIP1-HTRA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RAB11FIP1-HTRA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAB11FIP1

GO:0070164

negative regulation of adiponectin secretion

24040321

TgeneHTRA4

GO:0006508

proteolysis

18387192


check buttonFusion gene breakpoints across RAB11FIP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HTRA4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0EI-01ARAB11FIP1chr8

37727937

-HTRA4chr8

38836733

+
ChimerDB4BRCATCGA-BH-A0EI-01ARAB11FIP1chr8

37727937

-HTRA4chr8

38839171

+
ChimerDB4BRCATCGA-BH-A0EI-01ARAB11FIP1chr8

37727938

-HTRA4chr8

38836734

+
ChimerDB4BRCATCGA-BH-A0EI-01ARAB11FIP1chr8

37727938

-HTRA4chr8

38839172

+
ChimerDB4BRCATCGA-BH-A0EIRAB11FIP1chr8

37727937

-HTRA4chr8

38836733

+
ChimerDB4BRCATCGA-BH-A0EIRAB11FIP1chr8

37727937

-HTRA4chr8

38839171

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000287263RAB11FIP1chr837727938-ENST00000302495HTRA4chr838836734+27861757262221731
ENST00000330843RAB11FIP1chr837727938-ENST00000302495HTRA4chr838836734+467536461341101365
ENST00000287263RAB11FIP1chr837727937-ENST00000302495HTRA4chr838839171+27531757262188720
ENST00000330843RAB11FIP1chr837727937-ENST00000302495HTRA4chr838839171+464236461340771354
ENST00000287263RAB11FIP1chr837727937-ENST00000302495HTRA4chr838836733+27861757262221731
ENST00000330843RAB11FIP1chr837727937-ENST00000302495HTRA4chr838836733+467536461341101365
ENST00000287263RAB11FIP1chr837727938-ENST00000302495HTRA4chr838839172+27531757262188720
ENST00000330843RAB11FIP1chr837727938-ENST00000302495HTRA4chr838839172+464236461340771354

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000287263ENST00000302495RAB11FIP1chr837727938-HTRA4chr838836734+0.0016380570.9983619
ENST00000330843ENST00000302495RAB11FIP1chr837727938-HTRA4chr838836734+0.0007357690.9992642
ENST00000287263ENST00000302495RAB11FIP1chr837727937-HTRA4chr838839171+0.0016665280.9983335
ENST00000330843ENST00000302495RAB11FIP1chr837727937-HTRA4chr838839171+0.0015020960.99849796
ENST00000287263ENST00000302495RAB11FIP1chr837727937-HTRA4chr838836733+0.0016380570.9983619
ENST00000330843ENST00000302495RAB11FIP1chr837727937-HTRA4chr838836733+0.0007357690.9992642
ENST00000287263ENST00000302495RAB11FIP1chr837727938-HTRA4chr838839172+0.0016665280.9983335
ENST00000330843ENST00000302495RAB11FIP1chr837727938-HTRA4chr838839172+0.0015020960.99849796

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>71138_71138_1_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727937_ENST00000287263_HTRA4_chr8_38836733_ENST00000302495_length(amino acids)=731AA_BP=577
MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLSSGPAAAATLQL
TVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK
NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSAS
DVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTEN
LAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGS
EGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP
RLHPVKPMNAMATKVANCSLGTATIISENLNNEVMMKYGNSGGPLVNLDGDVIGVNSLRVTDGISFAIPSDRVRQFLAEYHEHQMKGKAF
SNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLRGKDN

--------------------------------------------------------------

>71138_71138_2_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727937_ENST00000287263_HTRA4_chr8_38839171_ENST00000302495_length(amino acids)=720AA_BP=577
MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLSSGPAAAATLQL
TVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK
NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSAS
DVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTEN
LAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGS
EGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP
RLHPVKPMNAMATKVANCSLGTATIISENLNNEVMMKDGDVIGVNSLRVTDGISFAIPSDRVRQFLAEYHEHQMKGKAFSNKKYLGLQML
SLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLRGKDNLLLTVIPETIN

--------------------------------------------------------------

>71138_71138_3_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727937_ENST00000330843_HTRA4_chr8_38836733_ENST00000302495_length(amino acids)=1365AA_BP=1211
MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLSSGPAAAATLQL
TVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK
NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSAS
DVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTEN
LAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGS
EGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP
RLEVSPEAQPTARLPSPTDSPSSLPPLPSSSGQASVPSELGHGADTQSSESPSVFSSLSSPIAAPISTSTPIESWPLVDRGQAKSEGPPL
LPKAELQTESLTPVPNSGSSALGSLFKQPSFPANKGTEDSLMGRTRETGTEKNTSSLELEESLPEQPETGRQEEELPRFPCKKQDYSPSS
GEAQEVPFALSLSSDGAVSPVGELAAGGDRDLESQAGSLVESKARDAAEEVAPPLPMGASVPSIDSMMRKLEEMGLNLRKDQKKTKKRVS
FSEQLFTEEAVAGAALLVEGHSSCPQELNPAWSVAGNASDGEPPESPHAEDSERESVTTPGPATCGAPASPADHLLLPSQEESFSEVPMS
EASSAKDTPLFRMEGEDALVTQYQSKASDHEGLLSDPLSDLQLVSDFKSPIMADLNLSLPSIPEVASDDERIDQVEDDGDQVEDDGETAK
SSTLDIGALSLGLVVPCPERGKGPSGEADRLVLGEGLCDFRLQAPQASVTAPSEQTTEFGIHKPHLGKSSSLDKQLPGPSGGEEEKPMGN
GSPSPPPGTSLDNPVPSPSPSEIFPVTHSFPSSAHSDTHHTSTAESQKKATAEGSAGRVENFGKRKPLLQAWVSPSETHPVSAQPGAGTG
SAKHRLHPVKPMNAMATKVANCSLGTATIISENLNNEVMMKYGNSGGPLVNLDGDVIGVNSLRVTDGISFAIPSDRVRQFLAEYHEHQMK
GKAFSNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLR

--------------------------------------------------------------

>71138_71138_4_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727937_ENST00000330843_HTRA4_chr8_38839171_ENST00000302495_length(amino acids)=1354AA_BP=1211
MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLSSGPAAAATLQL
TVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK
NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSAS
DVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTEN
LAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGS
EGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP
RLEVSPEAQPTARLPSPTDSPSSLPPLPSSSGQASVPSELGHGADTQSSESPSVFSSLSSPIAAPISTSTPIESWPLVDRGQAKSEGPPL
LPKAELQTESLTPVPNSGSSALGSLFKQPSFPANKGTEDSLMGRTRETGTEKNTSSLELEESLPEQPETGRQEEELPRFPCKKQDYSPSS
GEAQEVPFALSLSSDGAVSPVGELAAGGDRDLESQAGSLVESKARDAAEEVAPPLPMGASVPSIDSMMRKLEEMGLNLRKDQKKTKKRVS
FSEQLFTEEAVAGAALLVEGHSSCPQELNPAWSVAGNASDGEPPESPHAEDSERESVTTPGPATCGAPASPADHLLLPSQEESFSEVPMS
EASSAKDTPLFRMEGEDALVTQYQSKASDHEGLLSDPLSDLQLVSDFKSPIMADLNLSLPSIPEVASDDERIDQVEDDGDQVEDDGETAK
SSTLDIGALSLGLVVPCPERGKGPSGEADRLVLGEGLCDFRLQAPQASVTAPSEQTTEFGIHKPHLGKSSSLDKQLPGPSGGEEEKPMGN
GSPSPPPGTSLDNPVPSPSPSEIFPVTHSFPSSAHSDTHHTSTAESQKKATAEGSAGRVENFGKRKPLLQAWVSPSETHPVSAQPGAGTG
SAKHRLHPVKPMNAMATKVANCSLGTATIISENLNNEVMMKDGDVIGVNSLRVTDGISFAIPSDRVRQFLAEYHEHQMKGKAFSNKKYLG
LQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLRGKDNLLLTVIP

--------------------------------------------------------------

>71138_71138_5_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727938_ENST00000287263_HTRA4_chr8_38836734_ENST00000302495_length(amino acids)=731AA_BP=577
MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLSSGPAAAATLQL
TVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK
NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSAS
DVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTEN
LAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGS
EGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP
RLHPVKPMNAMATKVANCSLGTATIISENLNNEVMMKYGNSGGPLVNLDGDVIGVNSLRVTDGISFAIPSDRVRQFLAEYHEHQMKGKAF
SNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLRGKDN

--------------------------------------------------------------

>71138_71138_6_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727938_ENST00000287263_HTRA4_chr8_38839172_ENST00000302495_length(amino acids)=720AA_BP=577
MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLSSGPAAAATLQL
TVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK
NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSAS
DVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTEN
LAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGS
EGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP
RLHPVKPMNAMATKVANCSLGTATIISENLNNEVMMKDGDVIGVNSLRVTDGISFAIPSDRVRQFLAEYHEHQMKGKAFSNKKYLGLQML
SLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLRGKDNLLLTVIPETIN

--------------------------------------------------------------

>71138_71138_7_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727938_ENST00000330843_HTRA4_chr8_38836734_ENST00000302495_length(amino acids)=1365AA_BP=1211
MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLSSGPAAAATLQL
TVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK
NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSAS
DVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTEN
LAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGS
EGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP
RLEVSPEAQPTARLPSPTDSPSSLPPLPSSSGQASVPSELGHGADTQSSESPSVFSSLSSPIAAPISTSTPIESWPLVDRGQAKSEGPPL
LPKAELQTESLTPVPNSGSSALGSLFKQPSFPANKGTEDSLMGRTRETGTEKNTSSLELEESLPEQPETGRQEEELPRFPCKKQDYSPSS
GEAQEVPFALSLSSDGAVSPVGELAAGGDRDLESQAGSLVESKARDAAEEVAPPLPMGASVPSIDSMMRKLEEMGLNLRKDQKKTKKRVS
FSEQLFTEEAVAGAALLVEGHSSCPQELNPAWSVAGNASDGEPPESPHAEDSERESVTTPGPATCGAPASPADHLLLPSQEESFSEVPMS
EASSAKDTPLFRMEGEDALVTQYQSKASDHEGLLSDPLSDLQLVSDFKSPIMADLNLSLPSIPEVASDDERIDQVEDDGDQVEDDGETAK
SSTLDIGALSLGLVVPCPERGKGPSGEADRLVLGEGLCDFRLQAPQASVTAPSEQTTEFGIHKPHLGKSSSLDKQLPGPSGGEEEKPMGN
GSPSPPPGTSLDNPVPSPSPSEIFPVTHSFPSSAHSDTHHTSTAESQKKATAEGSAGRVENFGKRKPLLQAWVSPSETHPVSAQPGAGTG
SAKHRLHPVKPMNAMATKVANCSLGTATIISENLNNEVMMKYGNSGGPLVNLDGDVIGVNSLRVTDGISFAIPSDRVRQFLAEYHEHQMK
GKAFSNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLR

--------------------------------------------------------------

>71138_71138_8_RAB11FIP1-HTRA4_RAB11FIP1_chr8_37727938_ENST00000330843_HTRA4_chr8_38839172_ENST00000302495_length(amino acids)=1354AA_BP=1211
MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLSSGPAAAATLQL
TVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK
NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSAS
DVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTEN
LAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGS
EGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP
RLEVSPEAQPTARLPSPTDSPSSLPPLPSSSGQASVPSELGHGADTQSSESPSVFSSLSSPIAAPISTSTPIESWPLVDRGQAKSEGPPL
LPKAELQTESLTPVPNSGSSALGSLFKQPSFPANKGTEDSLMGRTRETGTEKNTSSLELEESLPEQPETGRQEEELPRFPCKKQDYSPSS
GEAQEVPFALSLSSDGAVSPVGELAAGGDRDLESQAGSLVESKARDAAEEVAPPLPMGASVPSIDSMMRKLEEMGLNLRKDQKKTKKRVS
FSEQLFTEEAVAGAALLVEGHSSCPQELNPAWSVAGNASDGEPPESPHAEDSERESVTTPGPATCGAPASPADHLLLPSQEESFSEVPMS
EASSAKDTPLFRMEGEDALVTQYQSKASDHEGLLSDPLSDLQLVSDFKSPIMADLNLSLPSIPEVASDDERIDQVEDDGDQVEDDGETAK
SSTLDIGALSLGLVVPCPERGKGPSGEADRLVLGEGLCDFRLQAPQASVTAPSEQTTEFGIHKPHLGKSSSLDKQLPGPSGGEEEKPMGN
GSPSPPPGTSLDNPVPSPSPSEIFPVTHSFPSSAHSDTHHTSTAESQKKATAEGSAGRVENFGKRKPLLQAWVSPSETHPVSAQPGAGTG
SAKHRLHPVKPMNAMATKVANCSLGTATIISENLNNEVMMKDGDVIGVNSLRVTDGISFAIPSDRVRQFLAEYHEHQMKGKAFSNKKYLG
LQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLRGKDNLLLTVIP

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:37727938/chr8:38836734)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000287263-45209_218577.0650.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000330843-56209_2181211.01284.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000330843-56556_6091211.01284.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000287263-45209_218577.0650.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000330843-56209_2181211.01284.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000330843-56556_6091211.01284.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000287263-45209_218577.0650.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000330843-56209_2181211.01284.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000330843-56556_6091211.01284.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000287263-45209_218577.0650.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000330843-56209_2181211.01284.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000330843-56556_6091211.01284.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000287263-451_126577.0650.0DomainC2
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000330843-561_1261211.01284.0DomainC2
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000287263-451_126577.0650.0DomainC2
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000330843-561_1261211.01284.0DomainC2
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000287263-451_126577.0650.0DomainC2
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000330843-561_1261211.01284.0DomainC2
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000287263-451_126577.0650.0DomainC2
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000330843-561_1261211.01284.0DomainC2
TgeneHTRA4chr8:37727937chr8:38836733ENST0000030249539383_474322.0477.0DomainPDZ
TgeneHTRA4chr8:37727937chr8:38839171ENST0000030249549383_474333.0477.0DomainPDZ
TgeneHTRA4chr8:37727938chr8:38836734ENST0000030249539383_474322.0477.0DomainPDZ
TgeneHTRA4chr8:37727938chr8:38839172ENST0000030249549383_474333.0477.0DomainPDZ

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000287263-45556_609577.0650.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000524118-13209_2180440.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000524118-13556_6090440.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000287263-45556_609577.0650.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000524118-13209_2180440.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000524118-13556_6090440.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000287263-45556_609577.0650.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000524118-13209_2180440.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000524118-13556_6090440.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000287263-45556_609577.0650.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000524118-13209_2180440.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000524118-13556_6090440.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000287263-451211_1273577.0650.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000330843-561211_12731211.01284.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000524118-131211_12730440.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727937chr8:38836733ENST00000524118-131_1260440.0DomainC2
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000287263-451211_1273577.0650.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000330843-561211_12731211.01284.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000524118-131211_12730440.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727937chr8:38839171ENST00000524118-131_1260440.0DomainC2
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000287263-451211_1273577.0650.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000330843-561211_12731211.01284.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000524118-131211_12730440.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727938chr8:38836734ENST00000524118-131_1260440.0DomainC2
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000287263-451211_1273577.0650.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000330843-561211_12731211.01284.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000524118-131211_12730440.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37727938chr8:38839172ENST00000524118-131_1260440.0DomainC2
TgeneHTRA4chr8:37727937chr8:38836733ENST000003024953936_99322.0477.0DomainIGFBP N-terminal
TgeneHTRA4chr8:37727937chr8:38836733ENST000003024953988_154322.0477.0DomainKazal-like
TgeneHTRA4chr8:37727937chr8:38839171ENST000003024954936_99333.0477.0DomainIGFBP N-terminal
TgeneHTRA4chr8:37727937chr8:38839171ENST000003024954988_154333.0477.0DomainKazal-like
TgeneHTRA4chr8:37727938chr8:38836734ENST000003024953936_99322.0477.0DomainIGFBP N-terminal
TgeneHTRA4chr8:37727938chr8:38836734ENST000003024953988_154322.0477.0DomainKazal-like
TgeneHTRA4chr8:37727938chr8:38839172ENST000003024954936_99333.0477.0DomainIGFBP N-terminal
TgeneHTRA4chr8:37727938chr8:38839172ENST000003024954988_154333.0477.0DomainKazal-like
TgeneHTRA4chr8:37727937chr8:38836733ENST0000030249539202_362322.0477.0RegionNote=Serine protease
TgeneHTRA4chr8:37727937chr8:38839171ENST0000030249549202_362333.0477.0RegionNote=Serine protease
TgeneHTRA4chr8:37727938chr8:38836734ENST0000030249539202_362322.0477.0RegionNote=Serine protease
TgeneHTRA4chr8:37727938chr8:38839172ENST0000030249549202_362333.0477.0RegionNote=Serine protease


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
RAB11FIP1_pLDDT.png
all structure
all structure
HTRA4_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RAB11FIP1
HTRA4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to RAB11FIP1-HTRA4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RAB11FIP1-HTRA4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource