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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:RAB21-DNM3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RAB21-DNM3
FusionPDB ID: 71222
FusionGDB2.0 ID: 71222
HgeneTgene
Gene symbol

RAB21

DNM3

Gene ID

23011

26052

Gene nameRAB21, member RAS oncogene familydynamin 3
Synonyms-Dyna III
Cytomap

12q21.1

1q24.3

Type of geneprotein-codingprotein-coding
Descriptionras-related protein Rab-21GTP-binding protein RAB21dynamin-3T-dynamindynamin family memberdynamin, testicular
Modification date2020031320200313
UniProtAcc.

Q9UQ16

Ensembl transtripts involved in fusion geneENST idsENST00000261263, ENST00000355305, 
ENST00000358155, ENST00000367731, 
ENST00000367733, ENST00000520906, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 6 X 6=46819 X 17 X 5=1615
# samples 1221
** MAII scorelog2(12/468*10)=-1.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/1615*10)=-2.94307293191516
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RAB21 [Title/Abstract] AND DNM3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RAB21(72149068)-DNM3(172050972), # samples:3
Anticipated loss of major functional domain due to fusion event.RAB21-DNM3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RAB21-DNM3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RAB21-DNM3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RAB21-DNM3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAB21

GO:0008089

anterograde axonal transport

22705394

HgeneRAB21

GO:0017157

regulation of exocytosis

22705394


check buttonFusion gene breakpoints across RAB21 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DNM3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-AATS-01ARAB21chr12

72149068

+DNM3chr1

172050972

+
ChimerDB4SARCTCGA-SG-A6Z7-01ARAB21chr12

72149068

-DNM3chr1

172050972

+
ChimerDB4SARCTCGA-SG-A6Z7-01ARAB21chr12

72149068

+DNM3chr1

172050972

+
ChimerDB4SARCTCGA-SG-A6Z7RAB21chr12

72149068

+DNM3chr1

172050971

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261263RAB21chr1272149068+ENST00000358155DNM3chr1172050972+64604152561584442
ENST00000261263RAB21chr1272149068+ENST00000367733DNM3chr1172050972+11564154141138
ENST00000261263RAB21chr1272149068+ENST00000355305DNM3chr1172050972+21164152561602448
ENST00000261263RAB21chr1272149068+ENST00000367731DNM3chr1172050972+64494152561572438
ENST00000261263RAB21chr1272149068+ENST00000520906DNM3chr1172050972+3319415256912218
ENST00000261263RAB21chr1272149068+ENST00000358155DNM3chr1172050971+64604152561584442
ENST00000261263RAB21chr1272149068+ENST00000367733DNM3chr1172050971+11564154141138
ENST00000261263RAB21chr1272149068+ENST00000355305DNM3chr1172050971+21164152561602448
ENST00000261263RAB21chr1272149068+ENST00000367731DNM3chr1172050971+64494152561572438
ENST00000261263RAB21chr1272149068+ENST00000520906DNM3chr1172050971+3319415256912218

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261263ENST00000358155RAB21chr1272149068+DNM3chr1172050972+8.33E-050.9999167
ENST00000261263ENST00000367733RAB21chr1272149068+DNM3chr1172050972+0.0084177250.99158233
ENST00000261263ENST00000355305RAB21chr1272149068+DNM3chr1172050972+0.0018837870.99811625
ENST00000261263ENST00000367731RAB21chr1272149068+DNM3chr1172050972+8.05E-050.9999194
ENST00000261263ENST00000520906RAB21chr1272149068+DNM3chr1172050972+0.0002937640.9997062
ENST00000261263ENST00000358155RAB21chr1272149068+DNM3chr1172050971+8.33E-050.9999167
ENST00000261263ENST00000367733RAB21chr1272149068+DNM3chr1172050971+0.0084177250.99158233
ENST00000261263ENST00000355305RAB21chr1272149068+DNM3chr1172050971+0.0018837870.99811625
ENST00000261263ENST00000367731RAB21chr1272149068+DNM3chr1172050971+8.05E-050.9999194
ENST00000261263ENST00000520906RAB21chr1272149068+DNM3chr1172050971+0.0002937640.9997062

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>71222_71222_1_RAB21-DNM3_RAB21_chr12_72149068_ENST00000261263_DNM3_chr1_172050971_ENST00000355305_length(amino acids)=448AA_BP=51
MAAAGGGGGGAAAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHKKTT
VGNQGTNLPPSRQIVIRKGWLTISNIGIMKGGSKGYWFVLTAESLSWYKDDEEKEKKYMLPLDNLKVRDVEKSFMSSKHIFALFNTEQRN
VYKDYRFLELACDSQEDVDSWKASLLRAGVYPDKSVAENDENGQAENFSMDPQLERQVETIRNLVDSYMSIINKCIRDLIPKTIMHLMIN
NVKDFINSELLAQLYSSEDQNTLMEESAEQAQRRDEMLRMYQALKEALGIIGDISTATVSTPAPPPVDDSWIQHSRRSPPPSPTTQRRPT

--------------------------------------------------------------

>71222_71222_2_RAB21-DNM3_RAB21_chr12_72149068_ENST00000261263_DNM3_chr1_172050971_ENST00000358155_length(amino acids)=442AA_BP=51
MAAAGGGGGGAAAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHKKTT
VGNQVIRKGWLTISNIGIMKGGSKGYWFVLTAESLSWYKDDEEKEKKYMLPLDNLKVRDVEKSFMSSKHIFALFNTEQRNVYKDYRFLEL
ACDSQEDVDSWKASLLRAGVYPDKSVGNNKAENDENGQAENFSMDPQLERQVETIRNLVDSYMSIINKCIRDLIPKTIMHLMINNVKDFI
NSELLAQLYSSEDQNTLMEESAEQAQRRDEMLRMYQALKEALGIIGDISTATVSTPAPPPVDDSWIQHSRRSPPPSPTTQRRPTLSAPLA

--------------------------------------------------------------

>71222_71222_3_RAB21-DNM3_RAB21_chr12_72149068_ENST00000261263_DNM3_chr1_172050971_ENST00000367731_length(amino acids)=438AA_BP=51
MAAAGGGGGGAAAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHKKTT
VGNQVIRKGWLTISNIGIMKGGSKGYWFVLTAESLSWYKDDEEKEKKYMLPLDNLKVRDVEKSFMSSKHIFALFNTEQRNVYKDYRFLEL
ACDSQEDVDSWKASLLRAGVYPDKSVAENDENGQAENFSMDPQLERQVETIRNLVDSYMSIINKCIRDLIPKTIMHLMINNVKDFINSEL
LAQLYSSEDQNTLMEESAEQAQRRDEMLRMYQALKEALGIIGDISTATVSTPAPPPVDDSWIQHSRRSPPPSPTTQRRPTLSAPLARPTS

--------------------------------------------------------------

>71222_71222_4_RAB21-DNM3_RAB21_chr12_72149068_ENST00000261263_DNM3_chr1_172050971_ENST00000367733_length(amino acids)=138AA_BP=
MQSGDVLVVKLVLAVAQHQRRLPHAAFPQQHHLERVGSARRRRPAAAAAGRSHPVASRPPEPECRAALPTAAAAPSQPRPAQPPPPRPRR

--------------------------------------------------------------

>71222_71222_5_RAB21-DNM3_RAB21_chr12_72149068_ENST00000261263_DNM3_chr1_172050971_ENST00000520906_length(amino acids)=218AA_BP=51
MAAAGGGGGGAAAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHKKTT
VGNQVIRKGWLTISNIGIMKGGSKGYWFVLTAESLSWYKDDEEKEKKYMLPLDNLKVRDVEKSFMSSKHIFALFNTEQRNVYKDYRFLEL

--------------------------------------------------------------

>71222_71222_6_RAB21-DNM3_RAB21_chr12_72149068_ENST00000261263_DNM3_chr1_172050972_ENST00000355305_length(amino acids)=448AA_BP=51
MAAAGGGGGGAAAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHKKTT
VGNQGTNLPPSRQIVIRKGWLTISNIGIMKGGSKGYWFVLTAESLSWYKDDEEKEKKYMLPLDNLKVRDVEKSFMSSKHIFALFNTEQRN
VYKDYRFLELACDSQEDVDSWKASLLRAGVYPDKSVAENDENGQAENFSMDPQLERQVETIRNLVDSYMSIINKCIRDLIPKTIMHLMIN
NVKDFINSELLAQLYSSEDQNTLMEESAEQAQRRDEMLRMYQALKEALGIIGDISTATVSTPAPPPVDDSWIQHSRRSPPPSPTTQRRPT

--------------------------------------------------------------

>71222_71222_7_RAB21-DNM3_RAB21_chr12_72149068_ENST00000261263_DNM3_chr1_172050972_ENST00000358155_length(amino acids)=442AA_BP=51
MAAAGGGGGGAAAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHKKTT
VGNQVIRKGWLTISNIGIMKGGSKGYWFVLTAESLSWYKDDEEKEKKYMLPLDNLKVRDVEKSFMSSKHIFALFNTEQRNVYKDYRFLEL
ACDSQEDVDSWKASLLRAGVYPDKSVGNNKAENDENGQAENFSMDPQLERQVETIRNLVDSYMSIINKCIRDLIPKTIMHLMINNVKDFI
NSELLAQLYSSEDQNTLMEESAEQAQRRDEMLRMYQALKEALGIIGDISTATVSTPAPPPVDDSWIQHSRRSPPPSPTTQRRPTLSAPLA

--------------------------------------------------------------

>71222_71222_8_RAB21-DNM3_RAB21_chr12_72149068_ENST00000261263_DNM3_chr1_172050972_ENST00000367731_length(amino acids)=438AA_BP=51
MAAAGGGGGGAAAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHKKTT
VGNQVIRKGWLTISNIGIMKGGSKGYWFVLTAESLSWYKDDEEKEKKYMLPLDNLKVRDVEKSFMSSKHIFALFNTEQRNVYKDYRFLEL
ACDSQEDVDSWKASLLRAGVYPDKSVAENDENGQAENFSMDPQLERQVETIRNLVDSYMSIINKCIRDLIPKTIMHLMINNVKDFINSEL
LAQLYSSEDQNTLMEESAEQAQRRDEMLRMYQALKEALGIIGDISTATVSTPAPPPVDDSWIQHSRRSPPPSPTTQRRPTLSAPLARPTS

--------------------------------------------------------------

>71222_71222_9_RAB21-DNM3_RAB21_chr12_72149068_ENST00000261263_DNM3_chr1_172050972_ENST00000367733_length(amino acids)=138AA_BP=
MQSGDVLVVKLVLAVAQHQRRLPHAAFPQQHHLERVGSARRRRPAAAAAGRSHPVASRPPEPECRAALPTAAAAPSQPRPAQPPPPRPRR

--------------------------------------------------------------

>71222_71222_10_RAB21-DNM3_RAB21_chr12_72149068_ENST00000261263_DNM3_chr1_172050972_ENST00000520906_length(amino acids)=218AA_BP=51
MAAAGGGGGGAAAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHKKTT
VGNQVIRKGWLTISNIGIMKGGSKGYWFVLTAESLSWYKDDEEKEKKYMLPLDNLKVRDVEKSFMSSKHIFALFNTEQRNVYKDYRFLEL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:72149068/chr1:172050972)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DNM3

Q9UQ16

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAB21chr12:72149068chr1:172050971ENST00000261263+1748_5653.0226.0MotifEffector region
HgeneRAB21chr12:72149068chr1:172050972ENST00000261263+1748_5653.0226.0MotifEffector region
HgeneRAB21chr12:72149068chr1:172050971ENST00000261263+1726_3453.0226.0Nucleotide bindingNote=GTP
HgeneRAB21chr12:72149068chr1:172050972ENST00000261263+1726_3453.0226.0Nucleotide bindingNote=GTP
TgeneDNM3chr12:72149068chr1:172050971ENST000003553051021515_621474.0870.0DomainPH
TgeneDNM3chr12:72149068chr1:172050971ENST000003553051021659_750474.0870.0DomainGED
TgeneDNM3chr12:72149068chr1:172050971ENST000003581551021515_621474.0864.0DomainPH
TgeneDNM3chr12:72149068chr1:172050971ENST000003581551021659_750474.0864.0DomainGED
TgeneDNM3chr12:72149068chr1:172050971ENST000003677311020515_621474.0860.0DomainPH
TgeneDNM3chr12:72149068chr1:172050971ENST000003677311020659_750474.0860.0DomainGED
TgeneDNM3chr12:72149068chr1:172050972ENST000003553051021515_621474.0870.0DomainPH
TgeneDNM3chr12:72149068chr1:172050972ENST000003553051021659_750474.0870.0DomainGED
TgeneDNM3chr12:72149068chr1:172050972ENST000003581551021515_621474.0864.0DomainPH
TgeneDNM3chr12:72149068chr1:172050972ENST000003581551021659_750474.0864.0DomainGED
TgeneDNM3chr12:72149068chr1:172050972ENST000003677311020515_621474.0860.0DomainPH
TgeneDNM3chr12:72149068chr1:172050972ENST000003677311020659_750474.0860.0DomainGED

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAB21chr12:72149068chr1:172050971ENST00000261263+17132_13553.0226.0Nucleotide bindingNote=GTP
HgeneRAB21chr12:72149068chr1:172050971ENST00000261263+17162_16453.0226.0Nucleotide bindingNote=GTP
HgeneRAB21chr12:72149068chr1:172050971ENST00000261263+1774_7853.0226.0Nucleotide bindingGTP
HgeneRAB21chr12:72149068chr1:172050972ENST00000261263+17132_13553.0226.0Nucleotide bindingNote=GTP
HgeneRAB21chr12:72149068chr1:172050972ENST00000261263+17162_16453.0226.0Nucleotide bindingNote=GTP
HgeneRAB21chr12:72149068chr1:172050972ENST00000261263+1774_7853.0226.0Nucleotide bindingGTP
TgeneDNM3chr12:72149068chr1:172050971ENST00000355305102128_294474.0870.0DomainDynamin-type G
TgeneDNM3chr12:72149068chr1:172050971ENST00000358155102128_294474.0864.0DomainDynamin-type G
TgeneDNM3chr12:72149068chr1:172050971ENST00000367731102028_294474.0860.0DomainDynamin-type G
TgeneDNM3chr12:72149068chr1:172050972ENST00000355305102128_294474.0870.0DomainDynamin-type G
TgeneDNM3chr12:72149068chr1:172050972ENST00000358155102128_294474.0864.0DomainDynamin-type G
TgeneDNM3chr12:72149068chr1:172050972ENST00000367731102028_294474.0860.0DomainDynamin-type G
TgeneDNM3chr12:72149068chr1:172050971ENST000003553051021205_211474.0870.0Nucleotide bindingGTP
TgeneDNM3chr12:72149068chr1:172050971ENST000003553051021236_239474.0870.0Nucleotide bindingGTP
TgeneDNM3chr12:72149068chr1:172050971ENST00000355305102138_46474.0870.0Nucleotide bindingGTP
TgeneDNM3chr12:72149068chr1:172050971ENST000003581551021205_211474.0864.0Nucleotide bindingGTP
TgeneDNM3chr12:72149068chr1:172050971ENST000003581551021236_239474.0864.0Nucleotide bindingGTP
TgeneDNM3chr12:72149068chr1:172050971ENST00000358155102138_46474.0864.0Nucleotide bindingGTP
TgeneDNM3chr12:72149068chr1:172050971ENST000003677311020205_211474.0860.0Nucleotide bindingGTP
TgeneDNM3chr12:72149068chr1:172050971ENST000003677311020236_239474.0860.0Nucleotide bindingGTP
TgeneDNM3chr12:72149068chr1:172050971ENST00000367731102038_46474.0860.0Nucleotide bindingGTP
TgeneDNM3chr12:72149068chr1:172050972ENST000003553051021205_211474.0870.0Nucleotide bindingGTP
TgeneDNM3chr12:72149068chr1:172050972ENST000003553051021236_239474.0870.0Nucleotide bindingGTP
TgeneDNM3chr12:72149068chr1:172050972ENST00000355305102138_46474.0870.0Nucleotide bindingGTP
TgeneDNM3chr12:72149068chr1:172050972ENST000003581551021205_211474.0864.0Nucleotide bindingGTP
TgeneDNM3chr12:72149068chr1:172050972ENST000003581551021236_239474.0864.0Nucleotide bindingGTP
TgeneDNM3chr12:72149068chr1:172050972ENST00000358155102138_46474.0864.0Nucleotide bindingGTP
TgeneDNM3chr12:72149068chr1:172050972ENST000003677311020205_211474.0860.0Nucleotide bindingGTP
TgeneDNM3chr12:72149068chr1:172050972ENST000003677311020236_239474.0860.0Nucleotide bindingGTP
TgeneDNM3chr12:72149068chr1:172050972ENST00000367731102038_46474.0860.0Nucleotide bindingGTP
TgeneDNM3chr12:72149068chr1:172050971ENST000003553051021136_139474.0870.0RegionG3 motif
TgeneDNM3chr12:72149068chr1:172050971ENST000003553051021205_208474.0870.0RegionG4 motif
TgeneDNM3chr12:72149068chr1:172050971ENST000003553051021235_238474.0870.0RegionG5 motif
TgeneDNM3chr12:72149068chr1:172050971ENST00000355305102138_45474.0870.0RegionG1 motif
TgeneDNM3chr12:72149068chr1:172050971ENST00000355305102164_66474.0870.0RegionG2 motif
TgeneDNM3chr12:72149068chr1:172050971ENST000003581551021136_139474.0864.0RegionG3 motif
TgeneDNM3chr12:72149068chr1:172050971ENST000003581551021205_208474.0864.0RegionG4 motif
TgeneDNM3chr12:72149068chr1:172050971ENST000003581551021235_238474.0864.0RegionG5 motif
TgeneDNM3chr12:72149068chr1:172050971ENST00000358155102138_45474.0864.0RegionG1 motif
TgeneDNM3chr12:72149068chr1:172050971ENST00000358155102164_66474.0864.0RegionG2 motif
TgeneDNM3chr12:72149068chr1:172050971ENST000003677311020136_139474.0860.0RegionG3 motif
TgeneDNM3chr12:72149068chr1:172050971ENST000003677311020205_208474.0860.0RegionG4 motif
TgeneDNM3chr12:72149068chr1:172050971ENST000003677311020235_238474.0860.0RegionG5 motif
TgeneDNM3chr12:72149068chr1:172050971ENST00000367731102038_45474.0860.0RegionG1 motif
TgeneDNM3chr12:72149068chr1:172050971ENST00000367731102064_66474.0860.0RegionG2 motif
TgeneDNM3chr12:72149068chr1:172050972ENST000003553051021136_139474.0870.0RegionG3 motif
TgeneDNM3chr12:72149068chr1:172050972ENST000003553051021205_208474.0870.0RegionG4 motif
TgeneDNM3chr12:72149068chr1:172050972ENST000003553051021235_238474.0870.0RegionG5 motif
TgeneDNM3chr12:72149068chr1:172050972ENST00000355305102138_45474.0870.0RegionG1 motif
TgeneDNM3chr12:72149068chr1:172050972ENST00000355305102164_66474.0870.0RegionG2 motif
TgeneDNM3chr12:72149068chr1:172050972ENST000003581551021136_139474.0864.0RegionG3 motif
TgeneDNM3chr12:72149068chr1:172050972ENST000003581551021205_208474.0864.0RegionG4 motif
TgeneDNM3chr12:72149068chr1:172050972ENST000003581551021235_238474.0864.0RegionG5 motif
TgeneDNM3chr12:72149068chr1:172050972ENST00000358155102138_45474.0864.0RegionG1 motif
TgeneDNM3chr12:72149068chr1:172050972ENST00000358155102164_66474.0864.0RegionG2 motif
TgeneDNM3chr12:72149068chr1:172050972ENST000003677311020136_139474.0860.0RegionG3 motif
TgeneDNM3chr12:72149068chr1:172050972ENST000003677311020205_208474.0860.0RegionG4 motif
TgeneDNM3chr12:72149068chr1:172050972ENST000003677311020235_238474.0860.0RegionG5 motif
TgeneDNM3chr12:72149068chr1:172050972ENST00000367731102038_45474.0860.0RegionG1 motif
TgeneDNM3chr12:72149068chr1:172050972ENST00000367731102064_66474.0860.0RegionG2 motif


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>937_RAB21_72149068_DNM3_172050972_937_RAB21_72149068_DNM3_172050972_ranked_0.pdbRAB217214906872149068ENST00000520906DNM3chr1172050972+
MAAAGGGGGGAAAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHKKTT
VGNQGTNLPPSRQIVIRKGWLTISNIGIMKGGSKGYWFVLTAESLSWYKDDEEKEKKYMLPLDNLKVRDVEKSFMSSKHIFALFNTEQRN
VYKDYRFLELACDSQEDVDSWKASLLRAGVYPDKSVAENDENGQAENFSMDPQLERQVETIRNLVDSYMSIINKCIRDLIPKTIMHLMIN
NVKDFINSELLAQLYSSEDQNTLMEESAEQAQRRDEMLRMYQALKEALGIIGDISTATVSTPAPPPVDDSWIQHSRRSPPPSPTTQRRPT
448


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
RAB21_pLDDT.png
all structure
all structure
DNM3_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RAB21
DNM3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to RAB21-DNM3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RAB21-DNM3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource