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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:RABEP1-ZMYND15

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: RABEP1-ZMYND15
	FusionPDB ID: 71530
	FusionGDB2.0 ID: 71530
		Hgene	Tgene
	Gene symbol	RABEP1	ZMYND15
	Gene ID	9135	84225
	Gene name	rabaptin, RAB GTPase binding effector protein 1	zinc finger MYND-type containing 15
	Synonyms	RAB5EP\|RABPT5	SPGF14
	Cytomap	17p13.2	17p13.2
	Type of gene	protein-coding	protein-coding
	Description	rab GTPase-binding effector protein 1neurocrescinrabaptin-4rabaptin-5rabaptin-5alpharenal carcinoma antigen NY-REN-17	zinc finger MYND domain-containing protein 15
	Modification date	20200313	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000262477, ENST00000341923, ENST00000408982, ENST00000537505, ENST00000546142, ENST00000570487,	ENST00000269289, ENST00000433935, ENST00000573751, ENST00000592813,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	14 X 10 X 8=1120	2 X 2 X 2=8
	# samples	17	2
	** MAII score	log2(17/1120*10)=-2.71989208080726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context (manual curation of fusion genes in FusionPDB)	PubMed: RABEP1 [Title/Abstract] AND ZMYND15 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	RABEP1(5185815)-ZMYND15(4646598), # samples:2
Anticipated loss of major functional domain due to fusion event.	RABEP1-ZMYND15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RABEP1-ZMYND15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RABEP1-ZMYND15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RABEP1-ZMYND15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across RABEP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ZMYND15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-VQ-A8PE-01A	RABEP1	chr17	5185815	+	ZMYND15	chr17	4646598	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000408982	RABEP1	chr17	5185815	+	ENST00000433935	ZMYND15	chr17	4646598	+	1468	258	155	1342	395
ENST00000408982	RABEP1	chr17	5185815	+	ENST00000592813	ZMYND15	chr17	4646598	+	1349	258	155	1225	356
ENST00000408982	RABEP1	chr17	5185815	+	ENST00000269289	ZMYND15	chr17	4646598	+	1346	258	155	1225	356
ENST00000408982	RABEP1	chr17	5185815	+	ENST00000573751	ZMYND15	chr17	4646598	+	1493	258	155	1366	403
ENST00000262477	RABEP1	chr17	5185815	+	ENST00000433935	ZMYND15	chr17	4646598	+	1468	258	155	1342	395
ENST00000262477	RABEP1	chr17	5185815	+	ENST00000592813	ZMYND15	chr17	4646598	+	1349	258	155	1225	356
ENST00000262477	RABEP1	chr17	5185815	+	ENST00000269289	ZMYND15	chr17	4646598	+	1346	258	155	1225	356
ENST00000262477	RABEP1	chr17	5185815	+	ENST00000573751	ZMYND15	chr17	4646598	+	1493	258	155	1366	403
ENST00000537505	RABEP1	chr17	5185815	+	ENST00000433935	ZMYND15	chr17	4646598	+	1457	247	144	1331	395
ENST00000537505	RABEP1	chr17	5185815	+	ENST00000592813	ZMYND15	chr17	4646598	+	1338	247	144	1214	356
ENST00000537505	RABEP1	chr17	5185815	+	ENST00000269289	ZMYND15	chr17	4646598	+	1335	247	144	1214	356
ENST00000537505	RABEP1	chr17	5185815	+	ENST00000573751	ZMYND15	chr17	4646598	+	1482	247	144	1355	403
ENST00000546142	RABEP1	chr17	5185815	+	ENST00000433935	ZMYND15	chr17	4646598	+	1431	221	118	1305	395
ENST00000546142	RABEP1	chr17	5185815	+	ENST00000592813	ZMYND15	chr17	4646598	+	1312	221	118	1188	356
ENST00000546142	RABEP1	chr17	5185815	+	ENST00000269289	ZMYND15	chr17	4646598	+	1309	221	118	1188	356
ENST00000546142	RABEP1	chr17	5185815	+	ENST00000573751	ZMYND15	chr17	4646598	+	1456	221	118	1329	403
ENST00000341923	RABEP1	chr17	5185815	+	ENST00000433935	ZMYND15	chr17	4646598	+	1244	34	0	1118	372
ENST00000341923	RABEP1	chr17	5185815	+	ENST00000592813	ZMYND15	chr17	4646598	+	1125	34	0	1001	333
ENST00000341923	RABEP1	chr17	5185815	+	ENST00000269289	ZMYND15	chr17	4646598	+	1122	34	0	1001	333
ENST00000341923	RABEP1	chr17	5185815	+	ENST00000573751	ZMYND15	chr17	4646598	+	1269	34	0	1142	380

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000408982	ENST00000433935	RABEP1	chr17	5185815	+	ZMYND15	chr17	4646598	+	0.163533	0.836467
ENST00000408982	ENST00000592813	RABEP1	chr17	5185815	+	ZMYND15	chr17	4646598	+	0.2276887	0.77231133
ENST00000408982	ENST00000269289	RABEP1	chr17	5185815	+	ZMYND15	chr17	4646598	+	0.22861032	0.77138966
ENST00000408982	ENST00000573751	RABEP1	chr17	5185815	+	ZMYND15	chr17	4646598	+	0.17495121	0.8250488
ENST00000262477	ENST00000433935	RABEP1	chr17	5185815	+	ZMYND15	chr17	4646598	+	0.163533	0.836467
ENST00000262477	ENST00000592813	RABEP1	chr17	5185815	+	ZMYND15	chr17	4646598	+	0.2276887	0.77231133
ENST00000262477	ENST00000269289	RABEP1	chr17	5185815	+	ZMYND15	chr17	4646598	+	0.22861032	0.77138966
ENST00000262477	ENST00000573751	RABEP1	chr17	5185815	+	ZMYND15	chr17	4646598	+	0.17495121	0.8250488
ENST00000537505	ENST00000433935	RABEP1	chr17	5185815	+	ZMYND15	chr17	4646598	+	0.1640172	0.83598286
ENST00000537505	ENST00000592813	RABEP1	chr17	5185815	+	ZMYND15	chr17	4646598	+	0.22877733	0.77122265
ENST00000537505	ENST00000269289	RABEP1	chr17	5185815	+	ZMYND15	chr17	4646598	+	0.22890335	0.77109665
ENST00000537505	ENST00000573751	RABEP1	chr17	5185815	+	ZMYND15	chr17	4646598	+	0.17479068	0.8252094
ENST00000546142	ENST00000433935	RABEP1	chr17	5185815	+	ZMYND15	chr17	4646598	+	0.1689061	0.8310939
ENST00000546142	ENST00000592813	RABEP1	chr17	5185815	+	ZMYND15	chr17	4646598	+	0.24136773	0.75863224
ENST00000546142	ENST00000269289	RABEP1	chr17	5185815	+	ZMYND15	chr17	4646598	+	0.24160825	0.7583918
ENST00000546142	ENST00000573751	RABEP1	chr17	5185815	+	ZMYND15	chr17	4646598	+	0.18145734	0.8185426
ENST00000341923	ENST00000433935	RABEP1	chr17	5185815	+	ZMYND15	chr17	4646598	+	0.194872	0.80512804
ENST00000341923	ENST00000592813	RABEP1	chr17	5185815	+	ZMYND15	chr17	4646598	+	0.2821879	0.71781206
ENST00000341923	ENST00000269289	RABEP1	chr17	5185815	+	ZMYND15	chr17	4646598	+	0.28310412	0.7168959
ENST00000341923	ENST00000573751	RABEP1	chr17	5185815	+	ZMYND15	chr17	4646598	+	0.21415399	0.785846

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>71530_71530_1_RABEP1-ZMYND15_RABEP1_chr17_5185815_ENST00000262477_ZMYND15_chr17_4646598_ENST00000269289_length(amino acids)=356AA_BP=34
MSPREPRTPLPRPSPLPEAGRLVMAQPGPASQPDEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGFSRHPRGNTPSLSLLRGGDPYQ
LLQGDGTALMPPVPPHPPRGVFVPELNIQNKQSLKIHVVEAGKEFDLVMVFWELLVLLPHVALELQFVGDGLPPESDEQHFTLQRDSLEV
SVRPGSGISARPSSGTKEKGGRRDLQIKVSARPYHLFQGPKPDLVIGFNSGFALKDTWLRSLPRLQSLRVPAFFTESSEYSCVMDGQTMA

--------------------------------------------------------------

>71530_71530_2_RABEP1-ZMYND15_RABEP1_chr17_5185815_ENST00000262477_ZMYND15_chr17_4646598_ENST00000433935_length(amino acids)=395AA_BP=34
MSPREPRTPLPRPSPLPEAGRLVMAQPGPASQPDEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGFSRHPRGNTPSLSLLRGGDPYQ
LLQGDGTALMPPVPPHPPRGVFGSWQDYYTWRGLSLDSPIAVLLTYPLTVYYVITHLVPQSFPELNIQNKQSLKIHVVEAGKEFDLVMVF
WELLVLLPHVALELQFVGDGLPPESDEQHFTLQRDSLEVSVRPGSGISARPSSGTKEKGGRRDLQIKVSARPYHLFQGPKPDLVIGFNSG
FALKDTWLRSLPRLQSLRVPAFFTESSEYSCVMDGQTMAVATGGGTSPPQPNPFRSPFRLRAADNCMSWYCNAFIFHLVYKPAQGSGARP

--------------------------------------------------------------

>71530_71530_3_RABEP1-ZMYND15_RABEP1_chr17_5185815_ENST00000262477_ZMYND15_chr17_4646598_ENST00000573751_length(amino acids)=403AA_BP=34
MSPREPRTPLPRPSPLPEAGRLVMAQPGPASQPDEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGFSRHPRGNTPSLSLLRGGDPYQ
LLQGDGTALMPPVPPHPPRGVFGSWQDYYTWRGLSLDSPIAVLLTYPLTVYYVITHLVPQSFPELNIQNKQSLKIHVVEAGKEFDLVMVF
WELLVLLPHVALELQFVGDGLPPESDEQHFTLQRDSLEVSVRPGSGISARPSSGTKEKGGRRDLQIKVSARPYHLFQGPKPDLVIASPSS
LSAGFNSGFALKDTWLRSLPRLQSLRVPAFFTESSEYSCVMDGQTMAVATGGGTSPPQPNPFRSPFRLRAADNCMSWYCNAFIFHLVYKP

--------------------------------------------------------------

>71530_71530_4_RABEP1-ZMYND15_RABEP1_chr17_5185815_ENST00000262477_ZMYND15_chr17_4646598_ENST00000592813_length(amino acids)=356AA_BP=34
MSPREPRTPLPRPSPLPEAGRLVMAQPGPASQPDEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGFSRHPRGNTPSLSLLRGGDPYQ
LLQGDGTALMPPVPPHPPRGVFVPELNIQNKQSLKIHVVEAGKEFDLVMVFWELLVLLPHVALELQFVGDGLPPESDEQHFTLQRDSLEV
SVRPGSGISARPSSGTKEKGGRRDLQIKVSARPYHLFQGPKPDLVIGFNSGFALKDTWLRSLPRLQSLRVPAFFTESSEYSCVMDGQTMA

--------------------------------------------------------------

>71530_71530_5_RABEP1-ZMYND15_RABEP1_chr17_5185815_ENST00000341923_ZMYND15_chr17_4646598_ENST00000269289_length(amino acids)=333AA_BP=11
MAQPGPASQPDEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGFSRHPRGNTPSLSLLRGGDPYQLLQGDGTALMPPVPPHPPRGVFV
PELNIQNKQSLKIHVVEAGKEFDLVMVFWELLVLLPHVALELQFVGDGLPPESDEQHFTLQRDSLEVSVRPGSGISARPSSGTKEKGGRR
DLQIKVSARPYHLFQGPKPDLVIGFNSGFALKDTWLRSLPRLQSLRVPAFFTESSEYSCVMDGQTMAVATGGGTSPPQPNPFRSPFRLRA

--------------------------------------------------------------

>71530_71530_6_RABEP1-ZMYND15_RABEP1_chr17_5185815_ENST00000341923_ZMYND15_chr17_4646598_ENST00000433935_length(amino acids)=372AA_BP=11
MAQPGPASQPDEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGFSRHPRGNTPSLSLLRGGDPYQLLQGDGTALMPPVPPHPPRGVFG
SWQDYYTWRGLSLDSPIAVLLTYPLTVYYVITHLVPQSFPELNIQNKQSLKIHVVEAGKEFDLVMVFWELLVLLPHVALELQFVGDGLPP
ESDEQHFTLQRDSLEVSVRPGSGISARPSSGTKEKGGRRDLQIKVSARPYHLFQGPKPDLVIGFNSGFALKDTWLRSLPRLQSLRVPAFF
TESSEYSCVMDGQTMAVATGGGTSPPQPNPFRSPFRLRAADNCMSWYCNAFIFHLVYKPAQGSGARPAPGPPPPSPTPSAPPAPTRRRRG

--------------------------------------------------------------

>71530_71530_7_RABEP1-ZMYND15_RABEP1_chr17_5185815_ENST00000341923_ZMYND15_chr17_4646598_ENST00000573751_length(amino acids)=380AA_BP=11
MAQPGPASQPDEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGFSRHPRGNTPSLSLLRGGDPYQLLQGDGTALMPPVPPHPPRGVFG
SWQDYYTWRGLSLDSPIAVLLTYPLTVYYVITHLVPQSFPELNIQNKQSLKIHVVEAGKEFDLVMVFWELLVLLPHVALELQFVGDGLPP
ESDEQHFTLQRDSLEVSVRPGSGISARPSSGTKEKGGRRDLQIKVSARPYHLFQGPKPDLVIASPSSLSAGFNSGFALKDTWLRSLPRLQ
SLRVPAFFTESSEYSCVMDGQTMAVATGGGTSPPQPNPFRSPFRLRAADNCMSWYCNAFIFHLVYKPAQGSGARPAPGPPPPSPTPSAPP

--------------------------------------------------------------

>71530_71530_8_RABEP1-ZMYND15_RABEP1_chr17_5185815_ENST00000341923_ZMYND15_chr17_4646598_ENST00000592813_length(amino acids)=333AA_BP=11
MAQPGPASQPDEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGFSRHPRGNTPSLSLLRGGDPYQLLQGDGTALMPPVPPHPPRGVFV
PELNIQNKQSLKIHVVEAGKEFDLVMVFWELLVLLPHVALELQFVGDGLPPESDEQHFTLQRDSLEVSVRPGSGISARPSSGTKEKGGRR
DLQIKVSARPYHLFQGPKPDLVIGFNSGFALKDTWLRSLPRLQSLRVPAFFTESSEYSCVMDGQTMAVATGGGTSPPQPNPFRSPFRLRA

--------------------------------------------------------------

>71530_71530_9_RABEP1-ZMYND15_RABEP1_chr17_5185815_ENST00000408982_ZMYND15_chr17_4646598_ENST00000269289_length(amino acids)=356AA_BP=34
MSPREPRTPLPRPSPLPEAGRLVMAQPGPASQPDEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGFSRHPRGNTPSLSLLRGGDPYQ
LLQGDGTALMPPVPPHPPRGVFVPELNIQNKQSLKIHVVEAGKEFDLVMVFWELLVLLPHVALELQFVGDGLPPESDEQHFTLQRDSLEV
SVRPGSGISARPSSGTKEKGGRRDLQIKVSARPYHLFQGPKPDLVIGFNSGFALKDTWLRSLPRLQSLRVPAFFTESSEYSCVMDGQTMA

--------------------------------------------------------------

>71530_71530_10_RABEP1-ZMYND15_RABEP1_chr17_5185815_ENST00000408982_ZMYND15_chr17_4646598_ENST00000433935_length(amino acids)=395AA_BP=34
MSPREPRTPLPRPSPLPEAGRLVMAQPGPASQPDEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGFSRHPRGNTPSLSLLRGGDPYQ
LLQGDGTALMPPVPPHPPRGVFGSWQDYYTWRGLSLDSPIAVLLTYPLTVYYVITHLVPQSFPELNIQNKQSLKIHVVEAGKEFDLVMVF
WELLVLLPHVALELQFVGDGLPPESDEQHFTLQRDSLEVSVRPGSGISARPSSGTKEKGGRRDLQIKVSARPYHLFQGPKPDLVIGFNSG
FALKDTWLRSLPRLQSLRVPAFFTESSEYSCVMDGQTMAVATGGGTSPPQPNPFRSPFRLRAADNCMSWYCNAFIFHLVYKPAQGSGARP

--------------------------------------------------------------

>71530_71530_11_RABEP1-ZMYND15_RABEP1_chr17_5185815_ENST00000408982_ZMYND15_chr17_4646598_ENST00000573751_length(amino acids)=403AA_BP=34
MSPREPRTPLPRPSPLPEAGRLVMAQPGPASQPDEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGFSRHPRGNTPSLSLLRGGDPYQ
LLQGDGTALMPPVPPHPPRGVFGSWQDYYTWRGLSLDSPIAVLLTYPLTVYYVITHLVPQSFPELNIQNKQSLKIHVVEAGKEFDLVMVF
WELLVLLPHVALELQFVGDGLPPESDEQHFTLQRDSLEVSVRPGSGISARPSSGTKEKGGRRDLQIKVSARPYHLFQGPKPDLVIASPSS
LSAGFNSGFALKDTWLRSLPRLQSLRVPAFFTESSEYSCVMDGQTMAVATGGGTSPPQPNPFRSPFRLRAADNCMSWYCNAFIFHLVYKP

--------------------------------------------------------------

>71530_71530_12_RABEP1-ZMYND15_RABEP1_chr17_5185815_ENST00000408982_ZMYND15_chr17_4646598_ENST00000592813_length(amino acids)=356AA_BP=34
MSPREPRTPLPRPSPLPEAGRLVMAQPGPASQPDEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGFSRHPRGNTPSLSLLRGGDPYQ
LLQGDGTALMPPVPPHPPRGVFVPELNIQNKQSLKIHVVEAGKEFDLVMVFWELLVLLPHVALELQFVGDGLPPESDEQHFTLQRDSLEV
SVRPGSGISARPSSGTKEKGGRRDLQIKVSARPYHLFQGPKPDLVIGFNSGFALKDTWLRSLPRLQSLRVPAFFTESSEYSCVMDGQTMA

--------------------------------------------------------------

>71530_71530_13_RABEP1-ZMYND15_RABEP1_chr17_5185815_ENST00000537505_ZMYND15_chr17_4646598_ENST00000269289_length(amino acids)=356AA_BP=34
MSPREPRTPLPRPSPLPEAGRLVMAQPGPASQPDEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGFSRHPRGNTPSLSLLRGGDPYQ
LLQGDGTALMPPVPPHPPRGVFVPELNIQNKQSLKIHVVEAGKEFDLVMVFWELLVLLPHVALELQFVGDGLPPESDEQHFTLQRDSLEV
SVRPGSGISARPSSGTKEKGGRRDLQIKVSARPYHLFQGPKPDLVIGFNSGFALKDTWLRSLPRLQSLRVPAFFTESSEYSCVMDGQTMA

--------------------------------------------------------------

>71530_71530_14_RABEP1-ZMYND15_RABEP1_chr17_5185815_ENST00000537505_ZMYND15_chr17_4646598_ENST00000433935_length(amino acids)=395AA_BP=34
MSPREPRTPLPRPSPLPEAGRLVMAQPGPASQPDEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGFSRHPRGNTPSLSLLRGGDPYQ
LLQGDGTALMPPVPPHPPRGVFGSWQDYYTWRGLSLDSPIAVLLTYPLTVYYVITHLVPQSFPELNIQNKQSLKIHVVEAGKEFDLVMVF
WELLVLLPHVALELQFVGDGLPPESDEQHFTLQRDSLEVSVRPGSGISARPSSGTKEKGGRRDLQIKVSARPYHLFQGPKPDLVIGFNSG
FALKDTWLRSLPRLQSLRVPAFFTESSEYSCVMDGQTMAVATGGGTSPPQPNPFRSPFRLRAADNCMSWYCNAFIFHLVYKPAQGSGARP

--------------------------------------------------------------

>71530_71530_15_RABEP1-ZMYND15_RABEP1_chr17_5185815_ENST00000537505_ZMYND15_chr17_4646598_ENST00000573751_length(amino acids)=403AA_BP=34
MSPREPRTPLPRPSPLPEAGRLVMAQPGPASQPDEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGFSRHPRGNTPSLSLLRGGDPYQ
LLQGDGTALMPPVPPHPPRGVFGSWQDYYTWRGLSLDSPIAVLLTYPLTVYYVITHLVPQSFPELNIQNKQSLKIHVVEAGKEFDLVMVF
WELLVLLPHVALELQFVGDGLPPESDEQHFTLQRDSLEVSVRPGSGISARPSSGTKEKGGRRDLQIKVSARPYHLFQGPKPDLVIASPSS
LSAGFNSGFALKDTWLRSLPRLQSLRVPAFFTESSEYSCVMDGQTMAVATGGGTSPPQPNPFRSPFRLRAADNCMSWYCNAFIFHLVYKP

--------------------------------------------------------------

>71530_71530_16_RABEP1-ZMYND15_RABEP1_chr17_5185815_ENST00000537505_ZMYND15_chr17_4646598_ENST00000592813_length(amino acids)=356AA_BP=34
MSPREPRTPLPRPSPLPEAGRLVMAQPGPASQPDEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGFSRHPRGNTPSLSLLRGGDPYQ
LLQGDGTALMPPVPPHPPRGVFVPELNIQNKQSLKIHVVEAGKEFDLVMVFWELLVLLPHVALELQFVGDGLPPESDEQHFTLQRDSLEV
SVRPGSGISARPSSGTKEKGGRRDLQIKVSARPYHLFQGPKPDLVIGFNSGFALKDTWLRSLPRLQSLRVPAFFTESSEYSCVMDGQTMA

--------------------------------------------------------------

>71530_71530_17_RABEP1-ZMYND15_RABEP1_chr17_5185815_ENST00000546142_ZMYND15_chr17_4646598_ENST00000269289_length(amino acids)=356AA_BP=34
MSPREPRTPLPRPSPLPEAGRLVMAQPGPASQPDEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGFSRHPRGNTPSLSLLRGGDPYQ
LLQGDGTALMPPVPPHPPRGVFVPELNIQNKQSLKIHVVEAGKEFDLVMVFWELLVLLPHVALELQFVGDGLPPESDEQHFTLQRDSLEV
SVRPGSGISARPSSGTKEKGGRRDLQIKVSARPYHLFQGPKPDLVIGFNSGFALKDTWLRSLPRLQSLRVPAFFTESSEYSCVMDGQTMA

--------------------------------------------------------------

>71530_71530_18_RABEP1-ZMYND15_RABEP1_chr17_5185815_ENST00000546142_ZMYND15_chr17_4646598_ENST00000433935_length(amino acids)=395AA_BP=34
MSPREPRTPLPRPSPLPEAGRLVMAQPGPASQPDEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGFSRHPRGNTPSLSLLRGGDPYQ
LLQGDGTALMPPVPPHPPRGVFGSWQDYYTWRGLSLDSPIAVLLTYPLTVYYVITHLVPQSFPELNIQNKQSLKIHVVEAGKEFDLVMVF
WELLVLLPHVALELQFVGDGLPPESDEQHFTLQRDSLEVSVRPGSGISARPSSGTKEKGGRRDLQIKVSARPYHLFQGPKPDLVIGFNSG
FALKDTWLRSLPRLQSLRVPAFFTESSEYSCVMDGQTMAVATGGGTSPPQPNPFRSPFRLRAADNCMSWYCNAFIFHLVYKPAQGSGARP

--------------------------------------------------------------

>71530_71530_19_RABEP1-ZMYND15_RABEP1_chr17_5185815_ENST00000546142_ZMYND15_chr17_4646598_ENST00000573751_length(amino acids)=403AA_BP=34
MSPREPRTPLPRPSPLPEAGRLVMAQPGPASQPDEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGFSRHPRGNTPSLSLLRGGDPYQ
LLQGDGTALMPPVPPHPPRGVFGSWQDYYTWRGLSLDSPIAVLLTYPLTVYYVITHLVPQSFPELNIQNKQSLKIHVVEAGKEFDLVMVF
WELLVLLPHVALELQFVGDGLPPESDEQHFTLQRDSLEVSVRPGSGISARPSSGTKEKGGRRDLQIKVSARPYHLFQGPKPDLVIASPSS
LSAGFNSGFALKDTWLRSLPRLQSLRVPAFFTESSEYSCVMDGQTMAVATGGGTSPPQPNPFRSPFRLRAADNCMSWYCNAFIFHLVYKP

--------------------------------------------------------------

>71530_71530_20_RABEP1-ZMYND15_RABEP1_chr17_5185815_ENST00000546142_ZMYND15_chr17_4646598_ENST00000592813_length(amino acids)=356AA_BP=34
MSPREPRTPLPRPSPLPEAGRLVMAQPGPASQPDEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGFSRHPRGNTPSLSLLRGGDPYQ
LLQGDGTALMPPVPPHPPRGVFVPELNIQNKQSLKIHVVEAGKEFDLVMVFWELLVLLPHVALELQFVGDGLPPESDEQHFTLQRDSLEV
SVRPGSGISARPSSGTKEKGGRRDLQIKVSARPYHLFQGPKPDLVIGFNSGFALKDTWLRSLPRLQSLRVPAFFTESSEYSCVMDGQTMA

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:5185815/chr17:4646598)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ZMYND15

chr17:5185815

chr17:4646598

ENST00000269289

707_724

381.3333333333333

704.0

Compositional bias

Note=Pro-rich

Tgene

ZMYND15

chr17:5185815

chr17:4646598

ENST00000433935

707_724

381.3333333333333

743.0

Compositional bias

Note=Pro-rich

Tgene

ZMYND15

chr17:5185815

chr17:4646598

ENST00000573751

707_724

381.3333333333333

751.0

Compositional bias

Note=Pro-rich

Tgene

ZMYND15

chr17:5185815

chr17:4646598

ENST00000592813

707_724

381.3333333333333

704.0

Compositional bias

Note=Pro-rich

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RABEP1

chr17:5185815

chr17:4646598

ENST00000262477

11_345

11.333333333333334

1503.6666666666667

Coiled coil

Ontology_term=ECO:0000255

Hgene

RABEP1

chr17:5185815

chr17:4646598

ENST00000262477

534_816

11.333333333333334

1503.6666666666667

Coiled coil

Ontology_term=ECO:0000255

Hgene

RABEP1

chr17:5185815

chr17:4646598

ENST00000341923

11_345

11.333333333333334

830.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RABEP1

chr17:5185815

chr17:4646598

ENST00000341923

534_816

11.333333333333334

830.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RABEP1

chr17:5185815

chr17:4646598

ENST00000408982

11_345

11.333333333333334

1470.6666666666667

Coiled coil

Ontology_term=ECO:0000255

Hgene

RABEP1

chr17:5185815

chr17:4646598

ENST00000408982

534_816

11.333333333333334

1470.6666666666667

Coiled coil

Ontology_term=ECO:0000255

Hgene

RABEP1

chr17:5185815

chr17:4646598

ENST00000546142

11_345

11.333333333333334

863.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RABEP1

chr17:5185815

chr17:4646598

ENST00000546142

534_816

11.333333333333334

863.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ZMYND15

chr17:5185815

chr17:4646598

ENST00000269289

110_186

381.3333333333333

704.0

Compositional bias

Note=Glu-rich

Tgene

ZMYND15

chr17:5185815

chr17:4646598

ENST00000433935

110_186

381.3333333333333

743.0

Compositional bias

Note=Glu-rich

Tgene

ZMYND15

chr17:5185815

chr17:4646598

ENST00000573751

110_186

381.3333333333333

751.0

Compositional bias

Note=Glu-rich

Tgene

ZMYND15

chr17:5185815

chr17:4646598

ENST00000592813

110_186

381.3333333333333

704.0

Compositional bias

Note=Glu-rich

Tgene

ZMYND15

chr17:5185815

chr17:4646598

ENST00000269289

313_359

381.3333333333333

704.0

Zinc finger

MYND-type

Tgene

ZMYND15

chr17:5185815

chr17:4646598

ENST00000433935

313_359

381.3333333333333

743.0

Zinc finger

MYND-type

Tgene

ZMYND15

chr17:5185815

chr17:4646598

ENST00000573751

313_359

381.3333333333333

751.0

Zinc finger

MYND-type

Tgene

ZMYND15

chr17:5185815

chr17:4646598

ENST00000592813

313_359

381.3333333333333

704.0

Zinc finger

MYND-type

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
RABEP1
ZMYND15

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	RABEP1	chr17:5185815	chr17:4646598	ENST00000262477	+	1	19	435_447	11.333333333333334	1503.6666666666667	AP1G1%2C AP1G2%2C GGA1%2C GGA2 and GGA3
Hgene	RABEP1	chr17:5185815	chr17:4646598	ENST00000341923	+	1	17	435_447	11.333333333333334	830.0	AP1G1%2C AP1G2%2C GGA1%2C GGA2 and GGA3
Hgene	RABEP1	chr17:5185815	chr17:4646598	ENST00000408982	+	1	18	435_447	11.333333333333334	1470.6666666666667	AP1G1%2C AP1G2%2C GGA1%2C GGA2 and GGA3
Hgene	RABEP1	chr17:5185815	chr17:4646598	ENST00000546142	+	1	18	435_447	11.333333333333334	863.0	AP1G1%2C AP1G2%2C GGA1%2C GGA2 and GGA3

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Related Drugs to RABEP1-ZMYND15

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to RABEP1-ZMYND15

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source