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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:RAD51B-HMGA2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: RAD51B-HMGA2
	FusionPDB ID: 71745
	FusionGDB2.0 ID: 71745
		Hgene	Tgene
	Gene symbol	RAD51B	HMGA2
	Gene ID	5890	8091
	Gene name	RAD51 paralog B	high mobility group AT-hook 2
	Synonyms	R51H2\|RAD51L1\|REC2	BABL\|HMGI-C\|HMGIC\|LIPO\|STQTL9
	Cytomap	14q24.1	12q14.3
	Type of gene	protein-coding	protein-coding
	Description	DNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair protein	high mobility group protein HMGI-CHMGA2/KRT121P fusionhigh-mobility group (nonhistone chromosomal) protein isoform I-C
	Modification date	20200313	20200329
	UniProtAcc	O15315	P52926
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000469165, ENST00000390683, ENST00000471583, ENST00000487270, ENST00000487861, ENST00000488612,	ENST00000354636, ENST00000393577, ENST00000393578, ENST00000403681, ENST00000425208, ENST00000536545, ENST00000541363,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	22 X 15 X 11=3630	16 X 12 X 5=960
	# samples	22	15
	** MAII score	log2(22/3630*10)=-4.04439411935845 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/960*10)=-2.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: RAD51B [Title/Abstract] AND HMGA2 [Title/Abstract] AND fusion [Title/Abstract] Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas (pmid: 9892177)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	HMGA2(66232351)-RAD51B(68758600), # samples:3
Anticipated loss of major functional domain due to fusion event.	HMGA2-RAD51B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HMGA2-RAD51B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HMGA2-RAD51B seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. HMGA2-RAD51B seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. HMGA2-RAD51B seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. HMGA2-RAD51B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	HMGA2	GO:0000122	negative regulation of transcription by RNA polymerase II	14627817
Tgene	HMGA2	GO:0002062	chondrocyte differentiation	21484705
Tgene	HMGA2	GO:0006284	base-excision repair	19465398
Tgene	HMGA2	GO:0007095	mitotic G2 DNA damage checkpoint	16061642
Tgene	HMGA2	GO:0010564	regulation of cell cycle process	14645522
Tgene	HMGA2	GO:0010628	positive regulation of gene expression	18832382
Tgene	HMGA2	GO:0031052	chromosome breakage	19549901
Tgene	HMGA2	GO:0031507	heterochromatin assembly	16901784
Tgene	HMGA2	GO:0035978	histone H2A-S139 phosphorylation	16061642
Tgene	HMGA2	GO:0035986	senescence-associated heterochromatin focus assembly	16901784
Tgene	HMGA2	GO:0035988	chondrocyte proliferation	21484705
Tgene	HMGA2	GO:0042769	DNA damage response, detection of DNA damage	19465398
Tgene	HMGA2	GO:0043065	positive regulation of apoptotic process	16061642
Tgene	HMGA2	GO:0043066	negative regulation of apoptotic process	19465398
Tgene	HMGA2	GO:0043392	negative regulation of DNA binding	14645522
Tgene	HMGA2	GO:0043922	negative regulation by host of viral transcription	17005673
Tgene	HMGA2	GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	17005673
Tgene	HMGA2	GO:0045892	negative regulation of transcription, DNA-templated	18832382
Tgene	HMGA2	GO:0045893	positive regulation of transcription, DNA-templated	15225648\|15755872\|17005673\|17324944\|17426251
Tgene	HMGA2	GO:0045944	positive regulation of transcription by RNA polymerase II	14645522\|18832382
Tgene	HMGA2	GO:0071158	positive regulation of cell cycle arrest	16061642
Tgene	HMGA2	GO:0071902	positive regulation of protein serine/threonine kinase activity	19549901
Tgene	HMGA2	GO:0090402	oncogene-induced cell senescence	16901784
Tgene	HMGA2	GO:2000648	positive regulation of stem cell proliferation	21484705
Tgene	HMGA2	GO:2000679	positive regulation of transcription regulatory region DNA binding	18832382
Tgene	HMGA2	GO:2000685	positive regulation of cellular response to X-ray	16061642
Tgene	HMGA2	GO:2001022	positive regulation of response to DNA damage stimulus	16061642\|19465398
Tgene	HMGA2	GO:2001033	negative regulation of double-strand break repair via nonhomologous end joining	19549901
Tgene	HMGA2	GO:2001038	regulation of cellular response to drug	16061642

Fusion gene breakpoints across RAD51B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HMGA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB3	.	.	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+
ChimerKB4	.	.	RAD51B	chr14	68353737	+	HMGA2	chr12	68353737	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000487861	RAD51B	chr14	68353921	+	ENST00000403681	HMGA2	chr12	66221780	+	4055	833	29	1051	340
ENST00000487861	RAD51B	chr14	68353921	+	ENST00000541363	HMGA2	chr12	66221780	+	8443	833	29	1021	330
ENST00000487861	RAD51B	chr14	68353921	+	ENST00000393577	HMGA2	chr12	66221780	+	1185	833	29	1078	349
ENST00000487861	RAD51B	chr14	68353921	+	ENST00000393578	HMGA2	chr12	66221780	+	1309	833	29	994	321
ENST00000487861	RAD51B	chr14	68353921	+	ENST00000425208	HMGA2	chr12	66221780	+	1355	833	29	1000	323
ENST00000487861	RAD51B	chr14	68353921	+	ENST00000536545	HMGA2	chr12	66221780	+	1699	833	29	1165	378
ENST00000487861	RAD51B	chr14	68353921	+	ENST00000354636	HMGA2	chr12	66221780	+	1440	833	29	1042	337
ENST00000471583	RAD51B	chr14	68353921	+	ENST00000403681	HMGA2	chr12	66221780	+	4026	804	0	1022	340
ENST00000471583	RAD51B	chr14	68353921	+	ENST00000541363	HMGA2	chr12	66221780	+	8414	804	0	992	330
ENST00000471583	RAD51B	chr14	68353921	+	ENST00000393577	HMGA2	chr12	66221780	+	1156	804	0	1049	349
ENST00000471583	RAD51B	chr14	68353921	+	ENST00000393578	HMGA2	chr12	66221780	+	1280	804	0	965	321
ENST00000471583	RAD51B	chr14	68353921	+	ENST00000425208	HMGA2	chr12	66221780	+	1326	804	0	971	323
ENST00000471583	RAD51B	chr14	68353921	+	ENST00000536545	HMGA2	chr12	66221780	+	1670	804	0	1136	378
ENST00000471583	RAD51B	chr14	68353921	+	ENST00000354636	HMGA2	chr12	66221780	+	1411	804	0	1013	337
ENST00000487270	RAD51B	chr14	68353921	+	ENST00000403681	HMGA2	chr12	66221780	+	4026	804	0	1022	340
ENST00000487270	RAD51B	chr14	68353921	+	ENST00000541363	HMGA2	chr12	66221780	+	8414	804	0	992	330
ENST00000487270	RAD51B	chr14	68353921	+	ENST00000393577	HMGA2	chr12	66221780	+	1156	804	0	1049	349
ENST00000487270	RAD51B	chr14	68353921	+	ENST00000393578	HMGA2	chr12	66221780	+	1280	804	0	965	321
ENST00000487270	RAD51B	chr14	68353921	+	ENST00000425208	HMGA2	chr12	66221780	+	1326	804	0	971	323
ENST00000487270	RAD51B	chr14	68353921	+	ENST00000536545	HMGA2	chr12	66221780	+	1670	804	0	1136	378
ENST00000487270	RAD51B	chr14	68353921	+	ENST00000354636	HMGA2	chr12	66221780	+	1411	804	0	1013	337
ENST00000488612	RAD51B	chr14	68353921	+	ENST00000403681	HMGA2	chr12	66221780	+	4005	783	0	1001	333
ENST00000488612	RAD51B	chr14	68353921	+	ENST00000541363	HMGA2	chr12	66221780	+	8393	783	0	971	323
ENST00000488612	RAD51B	chr14	68353921	+	ENST00000393577	HMGA2	chr12	66221780	+	1135	783	0	1028	342
ENST00000488612	RAD51B	chr14	68353921	+	ENST00000393578	HMGA2	chr12	66221780	+	1259	783	0	944	314
ENST00000488612	RAD51B	chr14	68353921	+	ENST00000425208	HMGA2	chr12	66221780	+	1305	783	0	950	316
ENST00000488612	RAD51B	chr14	68353921	+	ENST00000536545	HMGA2	chr12	66221780	+	1649	783	0	1115	371
ENST00000488612	RAD51B	chr14	68353921	+	ENST00000354636	HMGA2	chr12	66221780	+	1390	783	0	992	330
ENST00000390683	RAD51B	chr14	68353921	+	ENST00000403681	HMGA2	chr12	66221780	+	3978	756	0	974	324
ENST00000390683	RAD51B	chr14	68353921	+	ENST00000541363	HMGA2	chr12	66221780	+	8366	756	0	944	314
ENST00000390683	RAD51B	chr14	68353921	+	ENST00000393577	HMGA2	chr12	66221780	+	1108	756	0	1001	333
ENST00000390683	RAD51B	chr14	68353921	+	ENST00000393578	HMGA2	chr12	66221780	+	1232	756	0	917	305
ENST00000390683	RAD51B	chr14	68353921	+	ENST00000425208	HMGA2	chr12	66221780	+	1278	756	0	923	307
ENST00000390683	RAD51B	chr14	68353921	+	ENST00000536545	HMGA2	chr12	66221780	+	1622	756	0	1088	362
ENST00000390683	RAD51B	chr14	68353921	+	ENST00000354636	HMGA2	chr12	66221780	+	1363	756	0	965	321

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>71745_71745_1_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000390683_HMGA2_chr12_66221780_ENST00000354636_length(amino acids)=321AA_BP=252
MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSAL
DEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLY
RELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEPTGEPSPKRPRGRPKGS

--------------------------------------------------------------

>71745_71745_2_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000390683_HMGA2_chr12_66221780_ENST00000393577_length(amino acids)=333AA_BP=252
MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSAL
DEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLY
RELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEPTGEPSPKRPRGRPKGS

--------------------------------------------------------------

>71745_71745_3_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000390683_HMGA2_chr12_66221780_ENST00000393578_length(amino acids)=305AA_BP=252
MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSAL
DEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLY
RELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEPTGEPSPKRPRGRPKGS

--------------------------------------------------------------

>71745_71745_4_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000390683_HMGA2_chr12_66221780_ENST00000403681_length(amino acids)=324AA_BP=252
MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSAL
DEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLY
RELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEPTGEPSPKRPRGRPKGS

--------------------------------------------------------------

>71745_71745_5_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000390683_HMGA2_chr12_66221780_ENST00000425208_length(amino acids)=307AA_BP=252
MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSAL
DEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLY
RELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEPTGEPSPKRPRGRPKGS

--------------------------------------------------------------

>71745_71745_6_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000390683_HMGA2_chr12_66221780_ENST00000536545_length(amino acids)=362AA_BP=252
MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSAL
DEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLY
RELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEPTGEPSPKRPRGRPKGS
KNKSPSKAAQKKAEATGEKRPRGRPRKWAGVQWYNLGSLQPPPPRFKQFSCLRLLSSWDYRHPPPHPANFCIFSRDRVSPCWPGWSRTPD

--------------------------------------------------------------

>71745_71745_7_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000390683_HMGA2_chr12_66221780_ENST00000541363_length(amino acids)=314AA_BP=252
MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSAL
DEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLY
RELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEPTGEPSPKRPRGRPKGS

--------------------------------------------------------------

>71745_71745_8_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000471583_HMGA2_chr12_66221780_ENST00000354636_length(amino acids)=337AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEP

--------------------------------------------------------------

>71745_71745_9_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000471583_HMGA2_chr12_66221780_ENST00000393577_length(amino acids)=349AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEP

--------------------------------------------------------------

>71745_71745_10_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000471583_HMGA2_chr12_66221780_ENST00000393578_length(amino acids)=321AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEP

--------------------------------------------------------------

>71745_71745_11_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000471583_HMGA2_chr12_66221780_ENST00000403681_length(amino acids)=340AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEP

--------------------------------------------------------------

>71745_71745_12_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000471583_HMGA2_chr12_66221780_ENST00000425208_length(amino acids)=323AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEP

--------------------------------------------------------------

>71745_71745_13_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000471583_HMGA2_chr12_66221780_ENST00000536545_length(amino acids)=378AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEP
TGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWAGVQWYNLGSLQPPPPRFKQFSCLRLLSSWDYRHPPPHPANFCIFS

--------------------------------------------------------------

>71745_71745_14_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000471583_HMGA2_chr12_66221780_ENST00000541363_length(amino acids)=330AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEP

--------------------------------------------------------------

>71745_71745_15_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000487270_HMGA2_chr12_66221780_ENST00000354636_length(amino acids)=337AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEP

--------------------------------------------------------------

>71745_71745_16_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000487270_HMGA2_chr12_66221780_ENST00000393577_length(amino acids)=349AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEP

--------------------------------------------------------------

>71745_71745_17_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000487270_HMGA2_chr12_66221780_ENST00000393578_length(amino acids)=321AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEP

--------------------------------------------------------------

>71745_71745_18_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000487270_HMGA2_chr12_66221780_ENST00000403681_length(amino acids)=340AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEP

--------------------------------------------------------------

>71745_71745_19_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000487270_HMGA2_chr12_66221780_ENST00000425208_length(amino acids)=323AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEP

--------------------------------------------------------------

>71745_71745_20_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000487270_HMGA2_chr12_66221780_ENST00000536545_length(amino acids)=378AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEP
TGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWAGVQWYNLGSLQPPPPRFKQFSCLRLLSSWDYRHPPPHPANFCIFS

--------------------------------------------------------------

>71745_71745_21_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000487270_HMGA2_chr12_66221780_ENST00000541363_length(amino acids)=330AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEP

--------------------------------------------------------------

>71745_71745_22_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000487861_HMGA2_chr12_66221780_ENST00000354636_length(amino acids)=337AA_BP=268
MCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEP

--------------------------------------------------------------

>71745_71745_23_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000487861_HMGA2_chr12_66221780_ENST00000393577_length(amino acids)=349AA_BP=268
MCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEP

--------------------------------------------------------------

>71745_71745_24_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000487861_HMGA2_chr12_66221780_ENST00000393578_length(amino acids)=321AA_BP=268
MCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEP

--------------------------------------------------------------

>71745_71745_25_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000487861_HMGA2_chr12_66221780_ENST00000403681_length(amino acids)=340AA_BP=268
MCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEP

--------------------------------------------------------------

>71745_71745_26_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000487861_HMGA2_chr12_66221780_ENST00000425208_length(amino acids)=323AA_BP=268
MCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEP

--------------------------------------------------------------

>71745_71745_27_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000487861_HMGA2_chr12_66221780_ENST00000536545_length(amino acids)=378AA_BP=268
MCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEP
TGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWAGVQWYNLGSLQPPPPRFKQFSCLRLLSSWDYRHPPPHPANFCIFS

--------------------------------------------------------------

>71745_71745_28_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000487861_HMGA2_chr12_66221780_ENST00000541363_length(amino acids)=330AA_BP=268
MCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEP

--------------------------------------------------------------

>71745_71745_29_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000488612_HMGA2_chr12_66221780_ENST00000354636_length(amino acids)=330AA_BP=261
LKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPA
FLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLL
LTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEPTGEPSPK

--------------------------------------------------------------

>71745_71745_30_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000488612_HMGA2_chr12_66221780_ENST00000393577_length(amino acids)=342AA_BP=261
LKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPA
FLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLL
LTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEPTGEPSPK

--------------------------------------------------------------

>71745_71745_31_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000488612_HMGA2_chr12_66221780_ENST00000393578_length(amino acids)=314AA_BP=261
LKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPA
FLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLL
LTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEPTGEPSPK

--------------------------------------------------------------

>71745_71745_32_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000488612_HMGA2_chr12_66221780_ENST00000403681_length(amino acids)=333AA_BP=261
LKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPA
FLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLL
LTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEPTGEPSPK

--------------------------------------------------------------

>71745_71745_33_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000488612_HMGA2_chr12_66221780_ENST00000425208_length(amino acids)=316AA_BP=261
LKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPA
FLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLL
LTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEPTGEPSPK

--------------------------------------------------------------

>71745_71745_34_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000488612_HMGA2_chr12_66221780_ENST00000536545_length(amino acids)=371AA_BP=261
LKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPA
FLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLL
LTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEPTGEPSPK
RPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWAGVQWYNLGSLQPPPPRFKQFSCLRLLSSWDYRHPPPHPANFCIFSRDRVSPC

--------------------------------------------------------------

>71745_71745_35_RAD51B-HMGA2_RAD51B_chr14_68353921_ENST00000488612_HMGA2_chr12_66221780_ENST00000541363_length(amino acids)=323AA_BP=261
LKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPA
FLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLL
LTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPEPTGEPSPK

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:66232351/chr12:68758600)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
RAD51B O15315	HMGA2 P52926
FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. {ECO:0000269\|PubMed:11751635, ECO:0000269\|PubMed:11751636, ECO:0000269\|PubMed:11842113, ECO:0000269\|PubMed:12441335, ECO:0000269\|PubMed:23108668, ECO:0000269\|PubMed:23149936}.	FUNCTION: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). {ECO:0000250\|UniProtKB:P52927, ECO:0000269\|PubMed:14645522, ECO:0000269\|PubMed:28796236}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (66) >>>66.pdbFusion protein BP residue: 252 CIF file (66) >>>66.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVH ELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSALDEALHGGVAC GSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAE RLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEII SKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFS IPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWEE	305
3D view using mol* of 66 (AA BP:252)


PDB file (67) >>>67.pdbFusion protein BP residue: 252 CIF file (67) >>>67.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVH ELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSALDEALHGGVAC GSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAE RLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEII SKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFS IPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWWL	307
3D view using mol* of 67 (AA BP:252)


PDB file (73) >>>73.pdbFusion protein BP residue: 261 CIF file (73) >>>73.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	LKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKV TGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSALD EALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYI DTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQR IESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASS LKYLAEEFSIPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRP	314
3D view using mol* of 73 (AA BP:261)


PDB file (74) >>>74.pdbFusion protein BP residue: 261 CIF file (74) >>>74.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVH ELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSALDEALHGGVAC GSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAE RLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEII SKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFS IPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQ	314
3D view using mol* of 74 (AA BP:261)


PDB file (76) >>>76.pdbFusion protein BP residue: 261 CIF file (76) >>>76.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	LKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKV TGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSALD EALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYI DTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQR IESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASS LKYLAEEFSIPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRP	316
3D view using mol* of 76 (AA BP:261)


PDB file (80) >>>80.pdbFusion protein BP residue: 268 CIF file (80) >>>80.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	MCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLS PLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLS TTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGL EGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELT CDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKF LAREASSLKYLAEEFSIPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAE	321
3D view using mol* of 80 (AA BP:268)


PDB file (81) >>>81.pdbFusion protein BP residue: 268 CIF file (81) >>>81.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLS PLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLS TTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGL EGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELT CDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKF LAREASSLKYLAEEFSIPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAE	321
3D view using mol* of 81 (AA BP:268)


PDB file (82) >>>82.pdbFusion protein BP residue: 268 CIF file (82) >>>82.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVH ELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSALDEALHGGVAC GSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAE RLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEII SKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFS IPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDN	321
3D view using mol* of 82 (AA BP:268)


PDB file (83) >>>83.pdbFusion protein BP residue: 261 CIF file (83) >>>83.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	MCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLS PLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLS TTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGL EGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELT CDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKF LAREASSLKYLAEEFSIPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAE	323
3D view using mol* of 83 (AA BP:261)


PDB file (84) >>>84.pdbFusion protein BP residue: 261 CIF file (84) >>>84.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLS PLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLS TTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGL EGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELT CDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKF LAREASSLKYLAEEFSIPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAE	323
3D view using mol* of 84 (AA BP:261)


PDB file (85) >>>85.pdbFusion protein BP residue: 261 CIF file (85) >>>85.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	LKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKV TGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSALD EALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYI DTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQR IESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASS LKYLAEEFSIPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRP	323
3D view using mol* of 85 (AA BP:261)


PDB file (87) >>>87.pdbFusion protein BP residue: 252 CIF file (87) >>>87.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVH ELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSALDEALHGGVAC GSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAE RLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEII SKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFS IPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQ	324
3D view using mol* of 87 (AA BP:252)


PDB file (90) >>>90.pdbFusion protein BP residue: 261 CIF file (90) >>>90.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	MCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLS PLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLS TTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGL EGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELT CDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKF LAREASSLKYLAEEFSIPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAE	330
3D view using mol* of 90 (AA BP:261)


PDB file (91) >>>91.pdbFusion protein BP residue: 261 CIF file (91) >>>91.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLS PLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLS TTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGL EGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELT CDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKF LAREASSLKYLAEEFSIPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAE	330
3D view using mol* of 91 (AA BP:261)


PDB file (92) >>>92.pdbFusion protein BP residue: 261 CIF file (92) >>>92.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	LKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKV TGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSALD EALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYI DTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQR IESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASS LKYLAEEFSIPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRP	330
3D view using mol* of 92 (AA BP:261)


PDB file (95) >>>95.pdbFusion protein BP residue: 261 CIF file (95) >>>95.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	LKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKV TGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSALD EALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYI DTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQR IESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASS LKYLAEEFSIPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRP	333
3D view using mol* of 95 (AA BP:261)


PDB file (96) >>>96.pdbFusion protein BP residue: 261 CIF file (96) >>>96.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVH ELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSALDEALHGGVAC GSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAE RLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEII SKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFS IPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQ	333
3D view using mol* of 96 (AA BP:261)


PDB file (97) >>>97.pdbFusion protein BP residue: 268 CIF file (97) >>>97.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	MCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLS PLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLS TTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGL EGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELT CDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKF LAREASSLKYLAEEFSIPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAE	337
3D view using mol* of 97 (AA BP:268)


PDB file (98) >>>98.pdbFusion protein BP residue: 268 CIF file (98) >>>98.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLS PLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLS TTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGL EGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELT CDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKF LAREASSLKYLAEEFSIPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAE	337
3D view using mol* of 98 (AA BP:268)


PDB file (100) >>>100.pdbFusion protein BP residue: 268 CIF file (100) >>>100.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	MCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLS PLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLS TTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGL EGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELT CDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKF LAREASSLKYLAEEFSIPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAE	340
3D view using mol* of 100 (AA BP:268)


PDB file (101) >>>101.pdbFusion protein BP residue: 268 CIF file (101) >>>101.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLS PLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLS TTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGL EGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELT CDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKF LAREASSLKYLAEEFSIPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAE	340
3D view using mol* of 101 (AA BP:268)


PDB file (104) >>>104.pdbFusion protein BP residue: 261 CIF file (104) >>>104.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	LKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKV TGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSALD EALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYI DTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQR IESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASS LKYLAEEFSIPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRP	342
3D view using mol* of 104 (AA BP:261)


PDB file (109) >>>109.pdbFusion protein BP residue: 268 CIF file (109) >>>109.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	MCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLS PLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLS TTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGL EGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELT CDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKF LAREASSLKYLAEEFSIPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAE	349
3D view using mol* of 109 (AA BP:268)


PDB file (110) >>>110.pdbFusion protein BP residue: 268 CIF file (110) >>>110.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLS PLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLS TTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGL EGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELT CDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKF LAREASSLKYLAEEFSIPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAE	349
3D view using mol* of 110 (AA BP:268)


PDB file (113) >>>113.pdbFusion protein BP residue: 252 CIF file (113) >>>113.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVH ELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSALDEALHGGVAC GSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAE RLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEII SKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFS IPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWAG VQWYNLGSLQPPPPRFKQFSCLRLLSSWDYRHPPPHPANFCIFSRDRVSP	362
3D view using mol* of 113 (AA BP:252)


PDB file (125) >>>125.pdbFusion protein BP residue: 261 CIF file (125) >>>125.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	LKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKV TGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSALD EALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYI DTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQR IESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASS LKYLAEEFSIPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRP RGRPRKWAGVQWYNLGSLQPPPPRFKQFSCLRLLSSWDYRHPPPHPANFC	371
3D view using mol* of 125 (AA BP:261)


PDB file (136) >>>136.pdbFusion protein BP residue: 268 CIF file (136) >>>136.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	MCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLS PLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLS TTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGL EGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELT CDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKF LAREASSLKYLAEEFSIPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAE ATGEKRPRGRPRKWAGVQWYNLGSLQPPPPRFKQFSCLRLLSSWDYRHPP	378
3D view using mol* of 136 (AA BP:268)


PDB file (137) >>>137.pdbFusion protein BP residue: 268 CIF file (137) >>>137.cif	RAD51B	chr14	68353921	+	HMGA2	chr12	66221780	+	LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLS PLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLS TTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGL EGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELT CDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKF LAREASSLKYLAEEFSIPEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAE ATGEKRPRGRPRKWAGVQWYNLGSLQPPPPRFKQFSCLRLLSSWDYRHPP	378
3D view using mol* of 137 (AA BP:268)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

RAD51B_pLDDT.png

HMGA2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

RAD51B_HMGA2_66_PAE.png (AA BP:252)

RAD51B_HMGA2_66_pLDDT.png (AA BP:252)

RAD51B_HMGA2_66_pLDDT_and_active_sites.png (AA BP:252)

RAD51B_HMGA2_66_violinplot.png (AA BP:252)

RAD51B_HMGA2_67_PAE.png (AA BP:252)

RAD51B_HMGA2_67_pLDDT.png (AA BP:252)

RAD51B_HMGA2_67_pLDDT_and_active_sites.png (AA BP:252)

RAD51B_HMGA2_67_violinplot.png (AA BP:252)

RAD51B_HMGA2_73_PAE.png (AA BP:261)

RAD51B_HMGA2_73_pLDDT.png (AA BP:261)

RAD51B_HMGA2_73_pLDDT_and_active_sites.png (AA BP:261)

RAD51B_HMGA2_73_violinplot.png (AA BP:261)

RAD51B_HMGA2_74_PAE.png (AA BP:261)

RAD51B_HMGA2_74_pLDDT.png (AA BP:261)

RAD51B_HMGA2_74_pLDDT_and_active_sites.png (AA BP:261)

RAD51B_HMGA2_74_violinplot.png (AA BP:261)

RAD51B_HMGA2_76_PAE.png (AA BP:261)

RAD51B_HMGA2_76_pLDDT.png (AA BP:261)

RAD51B_HMGA2_76_pLDDT_and_active_sites.png (AA BP:261)

RAD51B_HMGA2_76_violinplot.png (AA BP:261)

RAD51B_HMGA2_80_PAE.png (AA BP:268)

RAD51B_HMGA2_80_pLDDT.png (AA BP:268)

RAD51B_HMGA2_80_pLDDT_and_active_sites.png (AA BP:268)

RAD51B_HMGA2_80_violinplot.png (AA BP:268)

RAD51B_HMGA2_81_PAE.png (AA BP:268)

RAD51B_HMGA2_81_pLDDT.png (AA BP:268)

RAD51B_HMGA2_81_pLDDT_and_active_sites.png (AA BP:268)

RAD51B_HMGA2_81_violinplot.png (AA BP:268)

RAD51B_HMGA2_82_PAE.png (AA BP:268)

RAD51B_HMGA2_82_pLDDT.png (AA BP:268)

RAD51B_HMGA2_82_pLDDT_and_active_sites.png (AA BP:268)

RAD51B_HMGA2_82_violinplot.png (AA BP:268)

RAD51B_HMGA2_83_PAE.png (AA BP:261)

RAD51B_HMGA2_83_pLDDT.png (AA BP:261)

RAD51B_HMGA2_83_pLDDT_and_active_sites.png (AA BP:261)

RAD51B_HMGA2_83_violinplot.png (AA BP:261)

RAD51B_HMGA2_84_PAE.png (AA BP:261)

RAD51B_HMGA2_84_pLDDT.png (AA BP:261)

RAD51B_HMGA2_84_pLDDT_and_active_sites.png (AA BP:261)

RAD51B_HMGA2_84_violinplot.png (AA BP:261)

RAD51B_HMGA2_85_PAE.png (AA BP:261)

RAD51B_HMGA2_85_pLDDT.png (AA BP:261)

RAD51B_HMGA2_85_pLDDT_and_active_sites.png (AA BP:261)

RAD51B_HMGA2_85_violinplot.png (AA BP:261)

RAD51B_HMGA2_87_PAE.png (AA BP:252)

RAD51B_HMGA2_87_pLDDT.png (AA BP:252)

RAD51B_HMGA2_87_pLDDT_and_active_sites.png (AA BP:252)

RAD51B_HMGA2_87_violinplot.png (AA BP:252)

RAD51B_HMGA2_90_PAE.png (AA BP:261)

RAD51B_HMGA2_90_pLDDT.png (AA BP:261)

RAD51B_HMGA2_90_pLDDT_and_active_sites.png (AA BP:261)

RAD51B_HMGA2_90_violinplot.png (AA BP:261)

RAD51B_HMGA2_91_PAE.png (AA BP:261)

RAD51B_HMGA2_91_pLDDT.png (AA BP:261)

RAD51B_HMGA2_91_pLDDT_and_active_sites.png (AA BP:261)

RAD51B_HMGA2_91_violinplot.png (AA BP:261)

RAD51B_HMGA2_92_PAE.png (AA BP:261)

RAD51B_HMGA2_92_pLDDT.png (AA BP:261)

RAD51B_HMGA2_92_pLDDT_and_active_sites.png (AA BP:261)

RAD51B_HMGA2_92_violinplot.png (AA BP:261)

RAD51B_HMGA2_95_PAE.png (AA BP:261)

RAD51B_HMGA2_95_pLDDT.png (AA BP:261)

RAD51B_HMGA2_95_pLDDT_and_active_sites.png (AA BP:261)

RAD51B_HMGA2_95_violinplot.png (AA BP:261)

RAD51B_HMGA2_96_PAE.png (AA BP:261)

RAD51B_HMGA2_96_pLDDT.png (AA BP:261)

RAD51B_HMGA2_96_pLDDT_and_active_sites.png (AA BP:261)

RAD51B_HMGA2_96_violinplot.png (AA BP:261)

RAD51B_HMGA2_97_PAE.png (AA BP:268)

RAD51B_HMGA2_97_pLDDT.png (AA BP:268)

RAD51B_HMGA2_97_pLDDT_and_active_sites.png (AA BP:268)

RAD51B_HMGA2_97_violinplot.png (AA BP:268)

RAD51B_HMGA2_98_PAE.png (AA BP:268)

RAD51B_HMGA2_98_pLDDT.png (AA BP:268)

RAD51B_HMGA2_98_pLDDT_and_active_sites.png (AA BP:268)

RAD51B_HMGA2_98_violinplot.png (AA BP:268)

RAD51B_HMGA2_100_PAE.png (AA BP:268)

RAD51B_HMGA2_100_pLDDT.png (AA BP:268)

RAD51B_HMGA2_100_pLDDT_and_active_sites.png (AA BP:268)

RAD51B_HMGA2_100_violinplot.png (AA BP:268)

RAD51B_HMGA2_101_PAE.png (AA BP:268)

RAD51B_HMGA2_101_pLDDT.png (AA BP:268)

RAD51B_HMGA2_104_PAE.png (AA BP:261)

RAD51B_HMGA2_104_pLDDT.png (AA BP:261)

RAD51B_HMGA2_104_pLDDT_and_active_sites.png (AA BP:261)

RAD51B_HMGA2_104_violinplot.png (AA BP:261)

RAD51B_HMGA2_109_PAE.png (AA BP:268)

RAD51B_HMGA2_109_pLDDT.png (AA BP:268)

RAD51B_HMGA2_109_pLDDT_and_active_sites.png (AA BP:268)

RAD51B_HMGA2_109_violinplot.png (AA BP:268)

RAD51B_HMGA2_110_PAE.png (AA BP:268)

RAD51B_HMGA2_110_pLDDT.png (AA BP:268)

RAD51B_HMGA2_110_pLDDT_and_active_sites.png (AA BP:268)

RAD51B_HMGA2_110_violinplot.png (AA BP:268)

RAD51B_HMGA2_113_PAE.png (AA BP:252)

RAD51B_HMGA2_113_pLDDT.png (AA BP:252)

RAD51B_HMGA2_113_pLDDT_and_active_sites.png (AA BP:252)

RAD51B_HMGA2_113_violinplot.png (AA BP:252)

RAD51B_HMGA2_125_PAE.png (AA BP:261)

RAD51B_HMGA2_125_pLDDT.png (AA BP:261)

RAD51B_HMGA2_125_pLDDT_and_active_sites.png (AA BP:261)

RAD51B_HMGA2_125_violinplot.png (AA BP:261)

RAD51B_HMGA2_136_PAE.png (AA BP:268)

RAD51B_HMGA2_136_pLDDT.png (AA BP:268)

RAD51B_HMGA2_136_pLDDT_and_active_sites.png (AA BP:268)

RAD51B_HMGA2_136_violinplot.png (AA BP:268)

RAD51B_HMGA2_137_PAE.png (AA BP:268)

RAD51B_HMGA2_137_pLDDT.png (AA BP:268)

RAD51B_HMGA2_137_pLDDT_and_active_sites.png (AA BP:268)

RAD51B_HMGA2_137_violinplot.png (AA BP:268)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

RAD51B_HMGA2_66.png

RAD51B_HMGA2_67.png

RAD51B_HMGA2_73.png

RAD51B_HMGA2_76.png

RAD51B_HMGA2_80.png

RAD51B_HMGA2_81.png

RAD51B_HMGA2_82.png

RAD51B_HMGA2_83.png

RAD51B_HMGA2_84.png

RAD51B_HMGA2_85.png

RAD51B_HMGA2_87.png

RAD51B_HMGA2_90.png

RAD51B_HMGA2_91.png

RAD51B_HMGA2_92.png

RAD51B_HMGA2_95.png

RAD51B_HMGA2_96.png

RAD51B_HMGA2_100.png

RAD51B_HMGA2_101.png

RAD51B_HMGA2_104.png

RAD51B_HMGA2_109.png

RAD51B_HMGA2_110.png

RAD51B_HMGA2_125.png

RAD51B_HMGA2_136.png

RAD51B_HMGA2_137.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
66	1.043	135	1.09	440.069	0.631	0.702	0.869	0.445	0.831	0.535	1.684	Chain A: 79,80,81,99,100,101,134,199,200,203,204,2 05,206,207,245,246,249,250,251,252,253,304,305
67	0.985	237	1.017	866.761	0.641	0.656	0.82	0.502	0.971	0.517	1.009	Chain A: 1,2,3,4,5,7,8,25,26,58,59,60,61,62,63,65, 70,73,74,77,78,79,80,81,100,101,189,192,193,196,19 7,199,200,203,205,237,240,241,243,244,245,247,248, 249,250,251,252,253,254,255,303,304,305,306,307
73	1.063	370	1.102	816.683	0.519	0.741	0.891	0.745	0.865	0.86	1.433	Chain A: 9,10,13,17,67,68,69,70,71,72,82,83,86,87, 88,89,90,92,107,108,109,110,111,112,113,115,126,12 7,130,143,208,209,212,213,214,215,216,217,218,251, 252,253,254,255,256,257,258,259,260,261,262,263,26 4,265,314
74	1.059	488	1.085	1013.565	0.422	0.762	0.976	0.968	0.958	1.011	0.948	Chain A: 8,70,73,74,77,79,80,81,83,94,98,99,100,10 1,102,103,104,105,106,107,108,109,110,111,112,113, 114,115,116,117,118,121,134,144,199,200,203,204,20 5,206,207,208,209,210,211,212,213,214,217,238,239, 242,245,246,247,248,249,250,251,252,253,254
76	0.996	259	0.981	840.693	0.583	0.692	0.919	0.284	1.147	0.247	1.204	Chain A: 7,8,10,13,17,67,68,69,70,71,72,74,79,82,8 3,85,86,87,88,89,90,109,110,138,143,144,205,209,21 4,252,253,256,257,258,259,260,261,262,263,264,301, 302,303,304,305,306,308
80	1.016	230	1.015	676.396	0.516	0.722	0.969	0.486	1.099	0.442	1.949	Chain A: 14,15,17,20,24,74,75,77,78,79,81,86,89,90 ,93,95,96,97,116,117,150,215,216,219,220,221,223,2 58,259,260,261,262,263,264,265,266,267,268,269,320 ,321
81	1	242	0.999	838.978	0.577	0.699	0.902	0.242	1.105	0.219	1.944	Chain A: 14,15,16,17,20,24,74,75,77,78,79,81,86,89 ,90,93,95,96,97,116,117,145,150,151,215,216,219,22 0,221,259,260,263,264,265,266,267,268,269,270,312, 313,314,315,316,317
82	1.064	485	1.098	1043.749	0.435	0.754	0.961	1.016	0.903	1.125	1.237	Chain A: 1,4,8,58,59,61,62,63,70,73,74,77,78,79,80 ,81,83,90,94,98,99,100,101,102,103,104,105,106,107 ,114,117,118,121,134,199,200,203,204,205,206,207,2 08,209,210,211,212,213,242,245,246,247,248,249,250 ,251,252,253
83	0.957	78	0.975	267.883	0.562	0.712	0.932	0.748	0.868	0.862	1.143	Chain A: 19,21,22,23,24,29,32,33,35,36,40,41,42,44 ,208,209,211,212,213,216,253,257,260,261
84	0.988	95	0.941	196.882	0.451	0.707	1.041	1.047	1.226	0.854	0.686	Chain A: 228,229,232,233,236,237,238,240,241,242,2 43,244,247,251,310,311,312,313,314
85	1.044	443	1.063	839.321	0.45	0.755	0.991	0.835	1.013	0.825	1.014	Chain A: 17,79,82,83,86,87,88,89,90,92,99,103,107, 108,109,110,111,112,113,114,115,116,119,120,121,12 2,123,124,125,126,127,130,143,153,208,209,212,213, 214,215,216,217,218,219,220,221,222,226,247,248,25 1,254,255,257,258,259,260,261,262
87	1.052	513	1.076	1146.306	0.436	0.757	0.985	0.943	0.975	0.967	1.019	Chain A: 1,4,8,58,59,60,61,62,63,70,73,74,77,79,80 ,81,83,94,98,99,100,101,102,103,104,105,106,107,11 0,111,112,113,114,115,117,118,121,134,144,195,196, 199,200,203,204,205,206,207,208,209,210,211,212,21 3,217,235,238,239,242,244,245,246,247,248,249,250, 251,252,253,254
90	1.033444	553	1.053003	1264.984	0.443102	0.740943	0.969887	0.878103	1.017065	0.86337	0.999476	Chain A: 14,15,16,17,20,24,74,75,77,78,79,81,86,89 ,90,93,95,96,97,99,106,110,114,115,116,117,118,119 ,120,121,122,123,124,126,127,128,129,130,131,132,1 33,134,137,150,151,160,215,216,219,220,221,222,223 ,224,225,226,227,228,229,233,251,254,255,258,259,2 60,261,262,263,264,265,266,267,268,269,270
91	1.044	535	1.064	1262.926	0.43	0.754	0.981	0.904	1.009	0.895	1.013	Chain A: 14,16,17,20,24,74,75,77,78,79,81,86,89,90 ,93,95,96,97,99,101,106,110,114,115,116,117,118,11 9,120,121,122,123,126,127,128,129,130,131,132,133, 134,137,150,160,162,215,216,219,220,221,222,223,22 4,225,226,227,228,229,230,233,254,255,258,260,261, 262,263,264,265,266,267,268,269,270
92	1.06	461	1.093	894.887	0.452	0.749	0.977	1.082	0.909	1.191	0.96	Chain A: 83,86,87,88,89,90,92,99,103,107,108,109,1 10,111,112,113,114,115,116,119,120,121,122,123,124 ,125,126,127,130,138,143,144,153,208,209,212,213,2 14,215,216,217,218,219,220,221,222,244,247,248,251 ,254,255,258,259,260,261,262,264
95	1.034	541	1.05	1301.685	0.451	0.747	0.959	0.81	1.036	0.782	1.054	Chain A: 7,9,10,13,17,67,68,70,71,72,74,79,82,83,8 6,88,89,90,92,107,108,109,110,111,112,113,114,115, 116,117,119,120,121,122,123,124,125,126,127,130,14 3,152,153,204,208,212,213,214,215,216,217,218,219, 220,221,222,223,226,247,248,251,253,254,255,256,25 7,258,259,260,261,262,263
96	0.969	144	0.996	421.204	0.652	0.642	0.864	0.224	1.009	0.222	1.343	Chain A: 8,74,77,78,79,80,81,200,203,205,248,249,2 50,251,252,253,314,315,316,317,318,319,320,321,322
97	1.035	559	1.053	1275.617	0.447	0.746	0.967	0.772	1.025	0.753	1.055	Chain A: 14,15,16,17,20,74,75,77,78,79,81,86,89,90 ,93,94,95,96,97,99,114,115,116,117,118,119,120,121 ,122,123,126,127,128,129,130,131,132,133,134,137,1 45,150,160,215,216,219,220,221,222,223,224,225,226 ,227,228,229,233,254,255,258,260,261,262,263,264,2 65,266,267,268,269,270
98	1.045	517	1.071	1231.37	0.469	0.743	0.949	0.872	0.965	0.904	1.073	Chain A: 14,17,20,24,74,75,77,78,79,86,89,90,93,95 ,96,97,99,114,115,116,117,118,119,120,121,122,123, 126,127,128,129,130,131,133,134,137,150,160,215,21 6,219,220,221,222,223,224,225,226,227,228,229,233, 254,255,258,260,261,262,263,264,265,266,267,268,26 9,270
100	1.067	429	1.099	897.974	0.441	0.761	0.985	1.135	0.912	1.244	0.863	Chain A: 24,86,89,90,93,94,95,96,97,99,106,110,114 ,115,116,117,118,119,120,121,122,126,127,128,129,1 30,131,133,134,137,145,150,160,162,215,216,219,220 ,221,222,223,224,225,226,227,228,229,233,251,254,2 55,258,261,262,264,265,266,267,268,269
104	0.983	188	1.013	576.583	0.647	0.657	0.827	0.239	0.987	0.242	1.573	Chain A: 7,8,10,13,67,70,71,72,79,82,83,86,87,88,8 9,90,109,110,209,252,253,256,257,258,259,260,261,2 62,321,322,323,324,325,326,327,328,329,330,331
109	0.99	146	1.016	588.245	0.686	0.672	0.857	0.252	1.005	0.25	1.87	Chain A: 14,15,17,20,24,74,77,78,79,90,93,94,95,96 ,97,116,117,260,263,264,265,266,267,268,269,331,33 2,333,334,335,336,337,338
110	0.997	97	1.044	311.101	0.668	0.65	0.853	0.608	0.833	0.73	0.659	Chain A: 13,14,15,16,17,18,19,21,22,23,24,29,32,33 ,35,36,40,41,42,44,208,209,212,213,216,253,256,257 ,259,260,261
113	0.982	310	1.008	1029.343	0.626	0.662	0.875	0.433	1.011	0.428	1.171	Chain A: 1,2,3,4,8,28,58,59,61,62,63,64,65,70,73,7 4,76,77,78,79,80,81,99,100,101,102,129,134,189,192 ,193,194,195,196,197,200,205,237,240,241,243,244,2 45,247,248,249,250,251,252,253,254,255,328,329,330 ,331,332,333,334,335,336,337,338,339
125	1.003	110	1.036	361.865	0.575	0.678	0.899	0.988	0.954	1.036	0.89	Chain A: 1,2,3,6,7,8,9,11,12,14,35,37,40,41,42,43, 44,62,63,66,201,202,205,249,250,253,254
136	1.056	128	1.101	418.803	0.524	0.724	0.926	0.905	0.84	1.077	1.079	Chain A: 19,20,21,22,23,24,32,35,36,40,41,42,208,2 09,211,212,213,216,256,257,260,261,264,265,267,268 ,269,348,349,350,351,352,353
137	1.009	200	1.02	571.095	0.51	0.712	0.967	0.468	1.063	0.44	0.935	Chain A: 14,15,16,17,20,24,25,71,74,75,76,77,78,79 ,81,82,83,86,259,260,263,264,267,340,341,342,343,3 44,345,346,347,348,349,350

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB

ZINC ID

DrugBank ID

Drug name

Docking score

Glide gscore

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Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID

DrugBank ID

Drug name

Drug type

SMILES

Drug group

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID

mol_MW

dipole

SASA

FOSA

FISA

PISA

WPSA

volume

donorHB

accptHB

Human Oral Absorption

Percent Human Oral Absorption

Rule Of Five

Rule Of Three

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Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID

Smile

Surface Accessibility

Toxicity

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
HMGA2	RELA, NFKB1, PIAS3, RB1, PRMT6, NPM1, SMAD1, SMAD5, SMAD9, PRKCA, HDGF, PTBP1, APEX1, SYNCRIP, XRCC6, PSIP1, PA2G4, PCBP2, E4F1, OBSL1, HIST1H3A, CREB1, NFATC1, PCGF1, POU5F1, DLST, EZH2, SUZ12, MYC, TP53, MDM2, CSK, VRK1, HIST1H1B, PRKAG2, DUX4, DUX4L9, SYDE1, ARHGAP21, ARHGAP39, Plekhg5, ZNF263, MAFB, KAT2B, HIST1H2BG, LMNB1, NDUFAF7, CSNK2A1, LIG3, SUPT16H, VRK3, SP2, C1QBP, PARP2, TOP3A, CSNK2A2, XPC, RANBP17, PARP1, SUPV3L1, HIST2H2AC, HIST2H3PS2, KPNA4, USP7,
RAD51B	RAD51, RAD51C, RAD51D, XRCC2, SWSAP1, FAM9B, DKKL1, ARL4C, MUC20, ADAMTS4, HELQ, HNRNPL, SPDL1, BRCA1, TPT1, ABL1, MEOX2, RPAIN, ANAPC5, BAGE2, C15orf39, PRPF6, C5orf34, N4BP2L2, BANP, ANKHD1-EIF4EBP3, KLRC2, DSCC1, SATB2, ZNHIT6, PMS1, NUF2, APAF1, PRKACB, MAPRE2, CD300LB, PRKACG, TBC1D2B, MTR,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
RAD51B
HMGA2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to RAD51B-HMGA2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to RAD51B-HMGA2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	RAD51B	C0006142	Malignant neoplasm of breast	1	CTD_human
Hgene	RAD51B	C0013146	Drug abuse	1	CTD_human
Hgene	RAD51B	C0013170	Drug habituation	1	CTD_human
Hgene	RAD51B	C0013222	Drug Use Disorders	1	CTD_human
Hgene	RAD51B	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
Hgene	RAD51B	C0038580	Substance Dependence	1	CTD_human
Hgene	RAD51B	C0038586	Substance Use Disorders	1	CTD_human
Hgene	RAD51B	C0236969	Substance-Related Disorders	1	CTD_human
Hgene	RAD51B	C0238033	Carcinoma of Male Breast	1	CTD_human
Hgene	RAD51B	C0242788	Breast Neoplasms, Male	1	CTD_human
Hgene	RAD51B	C0678222	Breast Carcinoma	1	CTD_human
Hgene	RAD51B	C0740858	Substance abuse problem	1	CTD_human
Hgene	RAD51B	C1257931	Mammary Neoplasms, Human	1	CTD_human
Hgene	RAD51B	C1458155	Mammary Neoplasms	1	CTD_human
Hgene	RAD51B	C1510472	Drug Dependence	1	CTD_human
Hgene	RAD51B	C4316881	Prescription Drug Abuse	1	CTD_human
Hgene	RAD51B	C4704874	Mammary Carcinoma, Human	1	CTD_human
Tgene	HMGA2	C1519176	Salivary Gland Pleomorphic Adenoma	2	ORPHANET
Tgene	HMGA2	C0005612	Birth Weight	1	CTD_human
Tgene	HMGA2	C0006826	Malignant Neoplasms	1	CTD_human
Tgene	HMGA2	C0027626	Neoplasm Invasiveness	1	CTD_human
Tgene	HMGA2	C0027651	Neoplasms	1	CTD_human
Tgene	HMGA2	C0086692	Benign Neoplasm	1	CTD_human
Tgene	HMGA2	C0175693	Russell-Silver syndrome	1	GENOMICS_ENGLAND
Tgene	HMGA2	C0473935	Radiolabeled somatostatin analog study	1	GENOMICS_ENGLAND
Tgene	HMGA2	C0796160	MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE	1	GENOMICS_ENGLAND
Tgene	HMGA2	C1096309	Myolipoma	1	GENOMICS_ENGLAND
Tgene	HMGA2	C4305140	12q14 microdeletion syndrome	1	ORPHANET