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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:RAD51B-MARK3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: RAD51B-MARK3
	FusionPDB ID: 71750
	FusionGDB2.0 ID: 71750
		Hgene	Tgene
	Gene symbol	RAD51B	MARK3
	Gene ID	5890	4140
	Gene name	RAD51 paralog B	microtubule affinity regulating kinase 3
	Synonyms	R51H2\|RAD51L1\|REC2	CTAK1\|KP78\|PAR1A\|Par-1a\|VIPB
	Cytomap	14q24.1	14q32.32-q32.33
	Type of gene	protein-coding	protein-coding
	Description	DNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair protein	MAP/microtubule affinity-regulating kinase 3C-TAK1ELKL motif kinase 2EMK-2cdc25C-associated protein kinase 1protein kinase STK10ser/Thr protein kinase PAR-1serine/threonine-protein kinase p78
	Modification date	20200313	20200313
	UniProtAcc	O15315	P27448
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000469165, ENST00000390683, ENST00000471583, ENST00000487270, ENST00000487861, ENST00000488612,	ENST00000216288, ENST00000303622, ENST00000335102, ENST00000416682, ENST00000429436, ENST00000440884, ENST00000553942, ENST00000561071,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	22 X 15 X 11=3630	16 X 19 X 9=2736
	# samples	22	21
	** MAII score	log2(22/3630*10)=-4.04439411935845 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(21/2736*10)=-3.70360699721978 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: RAD51B [Title/Abstract] AND MARK3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	RAD51B(68353921)-MARK3(103946724), # samples:3
Anticipated loss of major functional domain due to fusion event.	RAD51B-MARK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RAD51B-MARK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RAD51B-MARK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RAD51B-MARK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	MARK3	GO:0018105	peptidyl-serine phosphorylation	9543386
Tgene	MARK3	GO:0032092	positive regulation of protein binding	9543386
Tgene	MARK3	GO:0035331	negative regulation of hippo signaling	28087714
Tgene	MARK3	GO:0036289	peptidyl-serine autophosphorylation	9543386

Fusion gene breakpoints across RAD51B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MARK3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-77-A5G6-01A	RAD51B	chr14	68353921	-	MARK3	chr14	103946724	+
ChimerDB4	LUSC	TCGA-77-A5G6-01A	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+
ChimerDB4	LUSC	TCGA-77-A5G6	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000487861	RAD51B	chr14	68353921	+	ENST00000440884	MARK3	chr14	103946724	+	1593	833	29	1567	512
ENST00000487861	RAD51B	chr14	68353921	+	ENST00000416682	MARK3	chr14	103946724	+	1674	833	29	1540	503
ENST00000487861	RAD51B	chr14	68353921	+	ENST00000429436	MARK3	chr14	103946724	+	2212	833	29	1612	527
ENST00000487861	RAD51B	chr14	68353921	+	ENST00000303622	MARK3	chr14	103946724	+	2145	833	29	1540	503
ENST00000487861	RAD51B	chr14	68353921	+	ENST00000216288	MARK3	chr14	103946724	+	2140	833	29	1540	503
ENST00000487861	RAD51B	chr14	68353921	+	ENST00000553942	MARK3	chr14	103946724	+	1604	833	29	1585	518
ENST00000487861	RAD51B	chr14	68353921	+	ENST00000335102	MARK3	chr14	103946724	+	1613	833	29	1612	528
ENST00000471583	RAD51B	chr14	68353921	+	ENST00000440884	MARK3	chr14	103946724	+	1564	804	0	1538	512
ENST00000471583	RAD51B	chr14	68353921	+	ENST00000416682	MARK3	chr14	103946724	+	1645	804	0	1511	503
ENST00000471583	RAD51B	chr14	68353921	+	ENST00000429436	MARK3	chr14	103946724	+	2183	804	0	1583	527
ENST00000471583	RAD51B	chr14	68353921	+	ENST00000303622	MARK3	chr14	103946724	+	2116	804	0	1511	503
ENST00000471583	RAD51B	chr14	68353921	+	ENST00000216288	MARK3	chr14	103946724	+	2111	804	0	1511	503
ENST00000471583	RAD51B	chr14	68353921	+	ENST00000553942	MARK3	chr14	103946724	+	1575	804	0	1556	518
ENST00000471583	RAD51B	chr14	68353921	+	ENST00000335102	MARK3	chr14	103946724	+	1584	804	0	1583	527
ENST00000487270	RAD51B	chr14	68353921	+	ENST00000440884	MARK3	chr14	103946724	+	1564	804	0	1538	512
ENST00000487270	RAD51B	chr14	68353921	+	ENST00000416682	MARK3	chr14	103946724	+	1645	804	0	1511	503
ENST00000487270	RAD51B	chr14	68353921	+	ENST00000429436	MARK3	chr14	103946724	+	2183	804	0	1583	527
ENST00000487270	RAD51B	chr14	68353921	+	ENST00000303622	MARK3	chr14	103946724	+	2116	804	0	1511	503
ENST00000487270	RAD51B	chr14	68353921	+	ENST00000216288	MARK3	chr14	103946724	+	2111	804	0	1511	503
ENST00000487270	RAD51B	chr14	68353921	+	ENST00000553942	MARK3	chr14	103946724	+	1575	804	0	1556	518
ENST00000487270	RAD51B	chr14	68353921	+	ENST00000335102	MARK3	chr14	103946724	+	1584	804	0	1583	527
ENST00000488612	RAD51B	chr14	68353921	+	ENST00000440884	MARK3	chr14	103946724	+	1543	783	0	1517	505
ENST00000488612	RAD51B	chr14	68353921	+	ENST00000416682	MARK3	chr14	103946724	+	1624	783	0	1490	496
ENST00000488612	RAD51B	chr14	68353921	+	ENST00000429436	MARK3	chr14	103946724	+	2162	783	0	1562	520
ENST00000488612	RAD51B	chr14	68353921	+	ENST00000303622	MARK3	chr14	103946724	+	2095	783	0	1490	496
ENST00000488612	RAD51B	chr14	68353921	+	ENST00000216288	MARK3	chr14	103946724	+	2090	783	0	1490	496
ENST00000488612	RAD51B	chr14	68353921	+	ENST00000553942	MARK3	chr14	103946724	+	1554	783	0	1535	511
ENST00000488612	RAD51B	chr14	68353921	+	ENST00000335102	MARK3	chr14	103946724	+	1563	783	0	1562	520
ENST00000390683	RAD51B	chr14	68353921	+	ENST00000440884	MARK3	chr14	103946724	+	1516	756	0	1490	496
ENST00000390683	RAD51B	chr14	68353921	+	ENST00000416682	MARK3	chr14	103946724	+	1597	756	0	1463	487
ENST00000390683	RAD51B	chr14	68353921	+	ENST00000429436	MARK3	chr14	103946724	+	2135	756	0	1535	511
ENST00000390683	RAD51B	chr14	68353921	+	ENST00000303622	MARK3	chr14	103946724	+	2068	756	0	1463	487
ENST00000390683	RAD51B	chr14	68353921	+	ENST00000216288	MARK3	chr14	103946724	+	2063	756	0	1463	487
ENST00000390683	RAD51B	chr14	68353921	+	ENST00000553942	MARK3	chr14	103946724	+	1527	756	0	1508	502
ENST00000390683	RAD51B	chr14	68353921	+	ENST00000335102	MARK3	chr14	103946724	+	1536	756	0	1535	511

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000487861	ENST00000440884	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.002465561	0.9975344
ENST00000487861	ENST00000416682	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.00249281	0.9975073
ENST00000487861	ENST00000429436	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.000863948	0.99913603
ENST00000487861	ENST00000303622	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.000894213	0.99910575
ENST00000487861	ENST00000216288	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.000923441	0.9990765
ENST00000487861	ENST00000553942	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.002505226	0.9974948
ENST00000487861	ENST00000335102	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.003170196	0.9968298
ENST00000471583	ENST00000440884	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.002439968	0.99756
ENST00000471583	ENST00000416682	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.002441349	0.9975586
ENST00000471583	ENST00000429436	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.000821018	0.99917895
ENST00000471583	ENST00000303622	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.000841805	0.99915814
ENST00000471583	ENST00000216288	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.000873656	0.9991264
ENST00000471583	ENST00000553942	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.002496806	0.9975032
ENST00000471583	ENST00000335102	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.003137175	0.9968629
ENST00000487270	ENST00000440884	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.002439968	0.99756
ENST00000487270	ENST00000416682	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.002441349	0.9975586
ENST00000487270	ENST00000429436	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.000821018	0.99917895
ENST00000487270	ENST00000303622	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.000841805	0.99915814
ENST00000487270	ENST00000216288	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.000873656	0.9991264
ENST00000487270	ENST00000553942	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.002496806	0.9975032
ENST00000487270	ENST00000335102	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.003137175	0.9968629
ENST00000488612	ENST00000440884	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.002931718	0.99706835
ENST00000488612	ENST00000416682	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.002917603	0.9970824
ENST00000488612	ENST00000429436	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.000965356	0.99903464
ENST00000488612	ENST00000303622	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.000983883	0.99901605
ENST00000488612	ENST00000216288	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.00103427	0.99896574
ENST00000488612	ENST00000553942	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.002989969	0.99701
ENST00000488612	ENST00000335102	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.003790966	0.996209
ENST00000390683	ENST00000440884	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.002705375	0.9972946
ENST00000390683	ENST00000416682	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.00266574	0.99733424
ENST00000390683	ENST00000429436	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.000864198	0.9991358
ENST00000390683	ENST00000303622	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.000878692	0.99912137
ENST00000390683	ENST00000216288	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.000915749	0.99908423
ENST00000390683	ENST00000553942	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.00279172	0.9972083
ENST00000390683	ENST00000335102	RAD51B	chr14	68353921	+	MARK3	chr14	103946724	+	0.003476229	0.9965238

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>71750_71750_1_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000390683_MARK3_chr14_103946724_ENST00000216288_length(amino acids)=487AA_BP=252
MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSAL
DEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLY
RELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSNTASGGMTRRNTYVCSE
RTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGST
NLFSKLTSKLTRSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEME

--------------------------------------------------------------

>71750_71750_2_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000390683_MARK3_chr14_103946724_ENST00000303622_length(amino acids)=487AA_BP=252
MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSAL
DEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLY
RELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSNTASGGMTRRNTYVCSE
RTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGST
NLFSKLTSKLTRSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEME

--------------------------------------------------------------

>71750_71750_3_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000390683_MARK3_chr14_103946724_ENST00000335102_length(amino acids)=511AA_BP=252
MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSAL
DEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLY
RELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSNTASGGMTRRNTYVCSE
RTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGST
NLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQ

--------------------------------------------------------------

>71750_71750_4_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000390683_MARK3_chr14_103946724_ENST00000416682_length(amino acids)=487AA_BP=252
MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSAL
DEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLY
RELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSNTASGGMTRRNTYVCSE
RTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGST
NLFSKLTSKLTRSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEME

--------------------------------------------------------------

>71750_71750_5_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000390683_MARK3_chr14_103946724_ENST00000429436_length(amino acids)=511AA_BP=252
MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSAL
DEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLY
RELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSNTASGGMTRRNTYVCSE
RTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGST
NLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQ

--------------------------------------------------------------

>71750_71750_6_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000390683_MARK3_chr14_103946724_ENST00000440884_length(amino acids)=496AA_BP=252
MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSAL
DEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLY
RELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSNTASGGMTRRNTYVCSE
RTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGST
NLFSKLTSKLTRRNMSFRFIKSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHA

--------------------------------------------------------------

>71750_71750_7_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000390683_MARK3_chr14_103946724_ENST00000553942_length(amino acids)=502AA_BP=252
MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSAL
DEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLY
RELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSNTASGGMTRRNTYVCSE
RTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGST
NLFSKLTSKLTRRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCV

--------------------------------------------------------------

>71750_71750_8_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000471583_MARK3_chr14_103946724_ENST00000216288_length(amino acids)=503AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSN
TASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSL
SHEATPLSQTRSRGSTNLFSKLTSKLTRSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFC

--------------------------------------------------------------

>71750_71750_9_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000471583_MARK3_chr14_103946724_ENST00000303622_length(amino acids)=503AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSN
TASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSL
SHEATPLSQTRSRGSTNLFSKLTSKLTRSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFC

--------------------------------------------------------------

>71750_71750_10_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000471583_MARK3_chr14_103946724_ENST00000335102_length(amino acids)=527AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSN
TASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSL
SHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMM

--------------------------------------------------------------

>71750_71750_11_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000471583_MARK3_chr14_103946724_ENST00000416682_length(amino acids)=503AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSN
TASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSL
SHEATPLSQTRSRGSTNLFSKLTSKLTRSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFC

--------------------------------------------------------------

>71750_71750_12_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000471583_MARK3_chr14_103946724_ENST00000429436_length(amino acids)=527AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSN
TASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSL
SHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMM

--------------------------------------------------------------

>71750_71750_13_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000471583_MARK3_chr14_103946724_ENST00000440884_length(amino acids)=512AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSN
TASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSL
SHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYE

--------------------------------------------------------------

>71750_71750_14_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000471583_MARK3_chr14_103946724_ENST00000553942_length(amino acids)=518AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSN
TASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSL
SHEATPLSQTRSRGSTNLFSKLTSKLTRRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDA

--------------------------------------------------------------

>71750_71750_15_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000487270_MARK3_chr14_103946724_ENST00000216288_length(amino acids)=503AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSN
TASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSL
SHEATPLSQTRSRGSTNLFSKLTSKLTRSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFC

--------------------------------------------------------------

>71750_71750_16_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000487270_MARK3_chr14_103946724_ENST00000303622_length(amino acids)=503AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSN
TASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSL
SHEATPLSQTRSRGSTNLFSKLTSKLTRSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFC

--------------------------------------------------------------

>71750_71750_17_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000487270_MARK3_chr14_103946724_ENST00000335102_length(amino acids)=527AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSN
TASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSL
SHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMM

--------------------------------------------------------------

>71750_71750_18_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000487270_MARK3_chr14_103946724_ENST00000416682_length(amino acids)=503AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSN
TASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSL
SHEATPLSQTRSRGSTNLFSKLTSKLTRSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFC

--------------------------------------------------------------

>71750_71750_19_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000487270_MARK3_chr14_103946724_ENST00000429436_length(amino acids)=527AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSN
TASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSL
SHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMM

--------------------------------------------------------------

>71750_71750_20_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000487270_MARK3_chr14_103946724_ENST00000440884_length(amino acids)=512AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSN
TASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSL
SHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYE

--------------------------------------------------------------

>71750_71750_21_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000487270_MARK3_chr14_103946724_ENST00000553942_length(amino acids)=518AA_BP=268
LCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSN
TASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSL
SHEATPLSQTRSRGSTNLFSKLTSKLTRRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDA

--------------------------------------------------------------

>71750_71750_22_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000487861_MARK3_chr14_103946724_ENST00000216288_length(amino acids)=503AA_BP=268
MCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSN
TASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSL
SHEATPLSQTRSRGSTNLFSKLTSKLTRSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFC

--------------------------------------------------------------

>71750_71750_23_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000487861_MARK3_chr14_103946724_ENST00000303622_length(amino acids)=503AA_BP=268
MCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSN
TASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSL
SHEATPLSQTRSRGSTNLFSKLTSKLTRSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFC

--------------------------------------------------------------

>71750_71750_24_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000487861_MARK3_chr14_103946724_ENST00000335102_length(amino acids)=528AA_BP=268
MCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSN
TASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSL
SHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMM

--------------------------------------------------------------

>71750_71750_25_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000487861_MARK3_chr14_103946724_ENST00000416682_length(amino acids)=503AA_BP=268
MCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSN
TASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSL
SHEATPLSQTRSRGSTNLFSKLTSKLTRSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFC

--------------------------------------------------------------

>71750_71750_26_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000487861_MARK3_chr14_103946724_ENST00000429436_length(amino acids)=527AA_BP=268
MCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSN
TASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSL
SHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMM

--------------------------------------------------------------

>71750_71750_27_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000487861_MARK3_chr14_103946724_ENST00000440884_length(amino acids)=512AA_BP=268
MCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSN
TASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSL
SHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYE

--------------------------------------------------------------

>71750_71750_28_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000487861_MARK3_chr14_103946724_ENST00000553942_length(amino acids)=518AA_BP=268
MCKGWGNLKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQR
SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYF
NTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSN
TASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSL
SHEATPLSQTRSRGSTNLFSKLTSKLTRRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDA

--------------------------------------------------------------

>71750_71750_29_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000488612_MARK3_chr14_103946724_ENST00000216288_length(amino acids)=496AA_BP=261
LKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPA
FLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLL
LTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSNTASGGMT
RRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPL
SQTRSRGSTNLFSKLTSKLTRSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHA

--------------------------------------------------------------

>71750_71750_30_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000488612_MARK3_chr14_103946724_ENST00000303622_length(amino acids)=496AA_BP=261
LKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPA
FLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLL
LTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSNTASGGMT
RRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPL
SQTRSRGSTNLFSKLTSKLTRSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHA

--------------------------------------------------------------

>71750_71750_31_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000488612_MARK3_chr14_103946724_ENST00000335102_length(amino acids)=520AA_BP=261
LKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPA
FLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLL
LTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSNTASGGMT
RRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPL
SQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVL

--------------------------------------------------------------

>71750_71750_32_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000488612_MARK3_chr14_103946724_ENST00000416682_length(amino acids)=496AA_BP=261
LKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPA
FLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLL
LTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSNTASGGMT
RRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPL
SQTRSRGSTNLFSKLTSKLTRSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHA

--------------------------------------------------------------

>71750_71750_33_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000488612_MARK3_chr14_103946724_ENST00000429436_length(amino acids)=520AA_BP=261
LKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPA
FLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLL
LTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSNTASGGMT
RRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPL
SQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVL

--------------------------------------------------------------

>71750_71750_34_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000488612_MARK3_chr14_103946724_ENST00000440884_length(amino acids)=505AA_BP=261
LKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPA
FLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLL
LTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSNTASGGMT
RRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPL
SQTRSRGSTNLFSKLTSKLTRRNMSFRFIKSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLL

--------------------------------------------------------------

>71750_71750_35_RAD51B-MARK3_RAD51B_chr14_68353921_ENST00000488612_MARK3_chr14_103946724_ENST00000553942_length(amino acids)=511AA_BP=261
LKVGCCRPGMGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPA
FLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLL
LTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPSNTASGGMT
RRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPL
SQTRSRGSTNLFSKLTSKLTRRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQ

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:68353921/chr14:103946724)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
RAD51B O15315	MARK3 P27448
FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. {ECO:0000269\|PubMed:11751635, ECO:0000269\|PubMed:11751636, ECO:0000269\|PubMed:11842113, ECO:0000269\|PubMed:12441335, ECO:0000269\|PubMed:23108668, ECO:0000269\|PubMed:23149936}.	FUNCTION: Serine/threonine-protein kinase (PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). {ECO:0000269\|PubMed:16980613, ECO:0000269\|PubMed:23666762, ECO:0000269\|PubMed:28087714}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RAD51B

chr14:68353921

chr14:103946724

ENST00000390683

108_115

252.0

367.0

Nucleotide binding

ATP

Hgene

RAD51B

chr14:68353921

chr14:103946724

ENST00000471583

108_115

252.0

351.0

Nucleotide binding

ATP

Hgene

RAD51B

chr14:68353921

chr14:103946724

ENST00000487270

108_115

252.0

385.0

Nucleotide binding

ATP

Hgene

RAD51B

chr14:68353921

chr14:103946724

ENST00000488612

108_115

252.0

495.6666666666667

Nucleotide binding

ATP

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000216288

704_753

478.0

714.0

Domain

KA1

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000303622

704_753

494.0

730.0

Domain

KA1

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000416682

704_753

517.0

753.0

Domain

KA1

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000429436

704_753

494.0

754.0

Domain

KA1

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000440884

704_753

415.0

660.0

Domain

KA1

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000553942

704_753

494.0

745.0

Domain

KA1

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000216288

326_365

478.0

714.0

Domain

UBA

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000216288

56_307

478.0

714.0

Domain

Protein kinase

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000303622

326_365

494.0

730.0

Domain

UBA

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000303622

56_307

494.0

730.0

Domain

Protein kinase

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000416682

326_365

517.0

753.0

Domain

UBA

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000416682

56_307

517.0

753.0

Domain

Protein kinase

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000429436

326_365

494.0

754.0

Domain

UBA

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000429436

56_307

494.0

754.0

Domain

Protein kinase

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000440884

326_365

415.0

660.0

Domain

UBA

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000440884

56_307

415.0

660.0

Domain

Protein kinase

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000553942

326_365

494.0

745.0

Domain

UBA

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000553942

56_307

494.0

745.0

Domain

Protein kinase

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000216288

62_70

478.0

714.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000303622

62_70

494.0

730.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000416682

62_70

517.0

753.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000429436

62_70

494.0

754.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000440884

62_70

415.0

660.0

Nucleotide binding

ATP

Tgene

MARK3

chr14:68353921

chr14:103946724

ENST00000553942

62_70

494.0

745.0

Nucleotide binding

ATP

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

AA seq

Len(AA seq)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

RAD51B_pLDDT.png

MARK3_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
RAD51B	RAD51, RAD51C, RAD51D, XRCC2, SWSAP1, FAM9B, DKKL1, ARL4C, MUC20, ADAMTS4, HELQ, HNRNPL, SPDL1, BRCA1, TPT1, ABL1, MEOX2, RPAIN, ANAPC5, BAGE2, C15orf39, PRPF6, C5orf34, N4BP2L2, BANP, ANKHD1-EIF4EBP3, KLRC2, DSCC1, SATB2, ZNHIT6, PMS1, NUF2, APAF1, PRKACB, MAPRE2, CD300LB, PRKACG, TBC1D2B, MTR,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
RAD51B
MARK3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to RAD51B-MARK3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to RAD51B-MARK3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	RAD51B	C0006142	Malignant neoplasm of breast	1	CTD_human
Hgene	RAD51B	C0013146	Drug abuse	1	CTD_human
Hgene	RAD51B	C0013170	Drug habituation	1	CTD_human
Hgene	RAD51B	C0013222	Drug Use Disorders	1	CTD_human
Hgene	RAD51B	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
Hgene	RAD51B	C0038580	Substance Dependence	1	CTD_human
Hgene	RAD51B	C0038586	Substance Use Disorders	1	CTD_human
Hgene	RAD51B	C0236969	Substance-Related Disorders	1	CTD_human
Hgene	RAD51B	C0238033	Carcinoma of Male Breast	1	CTD_human
Hgene	RAD51B	C0242788	Breast Neoplasms, Male	1	CTD_human
Hgene	RAD51B	C0678222	Breast Carcinoma	1	CTD_human
Hgene	RAD51B	C0740858	Substance abuse problem	1	CTD_human
Hgene	RAD51B	C1257931	Mammary Neoplasms, Human	1	CTD_human
Hgene	RAD51B	C1458155	Mammary Neoplasms	1	CTD_human
Hgene	RAD51B	C1510472	Drug Dependence	1	CTD_human
Hgene	RAD51B	C4316881	Prescription Drug Abuse	1	CTD_human
Hgene	RAD51B	C4704874	Mammary Carcinoma, Human	1	CTD_human