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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:RAPGEF6-USP33

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RAPGEF6-USP33
FusionPDB ID: 72267
FusionGDB2.0 ID: 72267
HgeneTgene
Gene symbol

RAPGEF6

USP33

Gene ID

51735

23032

Gene nameRap guanine nucleotide exchange factor 6ubiquitin specific peptidase 33
SynonymsKIA001LB|PDZ-GEF2|PDZGEF2|RA-GEF-2|RAGEF2VDU1
Cytomap

5q31.1

1p31.1

Type of geneprotein-codingprotein-coding
Descriptionrap guanine nucleotide exchange factor 6PDZ domain containing guanine nucleotide exchange factor (GEF) 2PDZ domain-containing guanine nucleotide exchange factor 2PDZ domain-containing guanine nucleotide exchange factor IRap guanine nucleotide exchangeubiquitin carboxyl-terminal hydrolase 33VHL-interacting deubiquitinating enzyme 1deubiquitinating enzyme 33pVHL-interacting deubiquitinating enzyme 1ubiquitin thioesterase 33ubiquitin thiolesterase 33ubiquitin-specific-processing protease 33
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000296859, ENST00000307984, 
ENST00000308008, ENST00000507093, 
ENST00000509018, ENST00000510071, 
ENST00000503398, ENST00000512052, 
ENST00000528150, ENST00000357428, 
ENST00000370792, ENST00000370793, 
ENST00000370794, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 10 X 6=60013 X 11 X 8=1144
# samples 1016
** MAII scorelog2(10/600*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1144*10)=-2.83794324189103
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RAPGEF6 [Title/Abstract] AND USP33 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RAPGEF6(130897670)-USP33(78205103), # samples:1
Anticipated loss of major functional domain due to fusion event.RAPGEF6-USP33 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RAPGEF6-USP33 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RAPGEF6-USP33 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RAPGEF6-USP33 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUSP33

GO:0009267

cellular response to starvation

24056301

TgeneUSP33

GO:0016579

protein deubiquitination

11739384|19363159|19424180|23486064

TgeneUSP33

GO:0070536

protein K63-linked deubiquitination

19363159

TgeneUSP33

GO:0071108

protein K48-linked deubiquitination

19363159


check buttonFusion gene breakpoints across RAPGEF6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across USP33 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADC370352RAPGEF6chr5

130897670

-USP33chr1

78205103

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000509018RAPGEF6chr5130897670-ENST00000370794USP33chr178205103-44255571823094970
ENST00000509018RAPGEF6chr5130897670-ENST00000357428USP33chr178205103-44215571823094970
ENST00000509018RAPGEF6chr5130897670-ENST00000370793USP33chr178205103-44215571823094970
ENST00000509018RAPGEF6chr5130897670-ENST00000370792USP33chr178205103-28365571822752856
ENST00000307984RAPGEF6chr5130897670-ENST00000370794USP33chr178205103-44255571823094970
ENST00000307984RAPGEF6chr5130897670-ENST00000357428USP33chr178205103-44215571823094970
ENST00000307984RAPGEF6chr5130897670-ENST00000370793USP33chr178205103-44215571823094970
ENST00000307984RAPGEF6chr5130897670-ENST00000370792USP33chr178205103-28365571822752856
ENST00000507093RAPGEF6chr5130897670-ENST00000370794USP33chr178205103-44015331583070970
ENST00000507093RAPGEF6chr5130897670-ENST00000357428USP33chr178205103-43975331583070970
ENST00000507093RAPGEF6chr5130897670-ENST00000370793USP33chr178205103-43975331583070970
ENST00000507093RAPGEF6chr5130897670-ENST00000370792USP33chr178205103-28125331582728856
ENST00000296859RAPGEF6chr5130897670-ENST00000370794USP33chr178205103-4300432572969970
ENST00000296859RAPGEF6chr5130897670-ENST00000357428USP33chr178205103-4296432572969970
ENST00000296859RAPGEF6chr5130897670-ENST00000370793USP33chr178205103-4296432572969970
ENST00000296859RAPGEF6chr5130897670-ENST00000370792USP33chr178205103-2711432572627856
ENST00000308008RAPGEF6chr5130897670-ENST00000370794USP33chr178205103-421935102888962
ENST00000308008RAPGEF6chr5130897670-ENST00000357428USP33chr178205103-421535102888962
ENST00000308008RAPGEF6chr5130897670-ENST00000370793USP33chr178205103-421535102888962
ENST00000308008RAPGEF6chr5130897670-ENST00000370792USP33chr178205103-263035102546848
ENST00000510071RAPGEF6chr5130897670-ENST00000370794USP33chr178205103-44205521773089970
ENST00000510071RAPGEF6chr5130897670-ENST00000357428USP33chr178205103-44165521773089970
ENST00000510071RAPGEF6chr5130897670-ENST00000370793USP33chr178205103-44165521773089970
ENST00000510071RAPGEF6chr5130897670-ENST00000370792USP33chr178205103-28315521772747856

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000509018ENST00000370794RAPGEF6chr5130897670-USP33chr178205103-0.0001348730.99986506
ENST00000509018ENST00000357428RAPGEF6chr5130897670-USP33chr178205103-0.0001378780.9998621
ENST00000509018ENST00000370793RAPGEF6chr5130897670-USP33chr178205103-0.0001378780.9998621
ENST00000509018ENST00000370792RAPGEF6chr5130897670-USP33chr178205103-0.0007527710.9992473
ENST00000307984ENST00000370794RAPGEF6chr5130897670-USP33chr178205103-0.0001348730.99986506
ENST00000307984ENST00000357428RAPGEF6chr5130897670-USP33chr178205103-0.0001378780.9998621
ENST00000307984ENST00000370793RAPGEF6chr5130897670-USP33chr178205103-0.0001378780.9998621
ENST00000307984ENST00000370792RAPGEF6chr5130897670-USP33chr178205103-0.0007527710.9992473
ENST00000507093ENST00000370794RAPGEF6chr5130897670-USP33chr178205103-0.0001342990.99986565
ENST00000507093ENST00000357428RAPGEF6chr5130897670-USP33chr178205103-0.0001371510.9998628
ENST00000507093ENST00000370793RAPGEF6chr5130897670-USP33chr178205103-0.0001371510.9998628
ENST00000507093ENST00000370792RAPGEF6chr5130897670-USP33chr178205103-0.00073060.9992694
ENST00000296859ENST00000370794RAPGEF6chr5130897670-USP33chr178205103-0.0001438670.9998561
ENST00000296859ENST00000357428RAPGEF6chr5130897670-USP33chr178205103-0.0001467210.99985325
ENST00000296859ENST00000370793RAPGEF6chr5130897670-USP33chr178205103-0.0001467210.99985325
ENST00000296859ENST00000370792RAPGEF6chr5130897670-USP33chr178205103-0.0008370040.99916303
ENST00000308008ENST00000370794RAPGEF6chr5130897670-USP33chr178205103-0.0001517920.9998481
ENST00000308008ENST00000357428RAPGEF6chr5130897670-USP33chr178205103-0.0001552410.9998448
ENST00000308008ENST00000370793RAPGEF6chr5130897670-USP33chr178205103-0.0001552410.9998448
ENST00000308008ENST00000370792RAPGEF6chr5130897670-USP33chr178205103-0.0009363690.9990637
ENST00000510071ENST00000370794RAPGEF6chr5130897670-USP33chr178205103-0.0001385980.99986136
ENST00000510071ENST00000357428RAPGEF6chr5130897670-USP33chr178205103-0.0001415340.9998585
ENST00000510071ENST00000370793RAPGEF6chr5130897670-USP33chr178205103-0.0001415340.9998585
ENST00000510071ENST00000370792RAPGEF6chr5130897670-USP33chr178205103-0.0007749820.999225

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>72267_72267_1_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000296859_USP33_chr1_78205103_ENST00000357428_length(amino acids)=970AA_BP=114
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI
PSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK
SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAEN
ENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLST
PQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGK
EDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKF
CKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQ
SVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDL
VLMLPQNIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGP

--------------------------------------------------------------

>72267_72267_2_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000296859_USP33_chr1_78205103_ENST00000370792_length(amino acids)=856AA_BP=114
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI
PSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK
SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAEN
ENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLST
PQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGK
EDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPE
ILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSES
TVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNI

--------------------------------------------------------------

>72267_72267_3_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000296859_USP33_chr1_78205103_ENST00000370793_length(amino acids)=970AA_BP=114
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI
PSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK
SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAEN
ENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLST
PQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGK
EDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKF
CKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQ
SVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDL
VLMLPQNIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGP

--------------------------------------------------------------

>72267_72267_4_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000296859_USP33_chr1_78205103_ENST00000370794_length(amino acids)=970AA_BP=114
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI
PSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK
SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAEN
ENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLST
PQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGK
EDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKF
CKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQ
SVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDL
VLMLPQNIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGP

--------------------------------------------------------------

>72267_72267_5_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000307984_USP33_chr1_78205103_ENST00000357428_length(amino acids)=970AA_BP=114
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI
PSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK
SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAEN
ENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLST
PQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGK
EDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKF
CKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQ
SVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDL
VLMLPQNIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGP

--------------------------------------------------------------

>72267_72267_6_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000307984_USP33_chr1_78205103_ENST00000370792_length(amino acids)=856AA_BP=114
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI
PSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK
SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAEN
ENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLST
PQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGK
EDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPE
ILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSES
TVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNI

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>72267_72267_7_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000307984_USP33_chr1_78205103_ENST00000370793_length(amino acids)=970AA_BP=114
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI
PSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK
SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAEN
ENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLST
PQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGK
EDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKF
CKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQ
SVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDL
VLMLPQNIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGP

--------------------------------------------------------------

>72267_72267_8_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000307984_USP33_chr1_78205103_ENST00000370794_length(amino acids)=970AA_BP=114
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI
PSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK
SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAEN
ENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLST
PQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGK
EDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKF
CKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQ
SVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDL
VLMLPQNIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGP

--------------------------------------------------------------

>72267_72267_9_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000308008_USP33_chr1_78205103_ENST00000357428_length(amino acids)=962AA_BP=106
MNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSVLVKGSMVL
PPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTTLKT
PLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVP
TTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAENENGSRCFS
EDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPSNE
GVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHS
SSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPE
ILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSES
TVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNI
WDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAV

--------------------------------------------------------------

>72267_72267_10_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000308008_USP33_chr1_78205103_ENST00000370792_length(amino acids)=848AA_BP=106
MNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSVLVKGSMVL
PPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTTLKT
PLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVP
TTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAENENGSRCFS
EDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPSNE
GVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHS
SSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKR
FRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAY
VLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSRY

--------------------------------------------------------------

>72267_72267_11_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000308008_USP33_chr1_78205103_ENST00000370793_length(amino acids)=962AA_BP=106
MNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSVLVKGSMVL
PPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTTLKT
PLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVP
TTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAENENGSRCFS
EDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPSNE
GVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHS
SSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPE
ILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSES
TVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNI
WDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAV

--------------------------------------------------------------

>72267_72267_12_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000308008_USP33_chr1_78205103_ENST00000370794_length(amino acids)=962AA_BP=106
MNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSVLVKGSMVL
PPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTTLKT
PLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVP
TTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAENENGSRCFS
EDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPSNE
GVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHS
SSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPE
ILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSES
TVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNI
WDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAV

--------------------------------------------------------------

>72267_72267_13_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000507093_USP33_chr1_78205103_ENST00000357428_length(amino acids)=970AA_BP=114
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI
PSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK
SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAEN
ENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLST
PQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGK
EDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKF
CKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQ
SVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDL
VLMLPQNIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGP

--------------------------------------------------------------

>72267_72267_14_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000507093_USP33_chr1_78205103_ENST00000370792_length(amino acids)=856AA_BP=114
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI
PSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK
SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAEN
ENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLST
PQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGK
EDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPE
ILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSES
TVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNI

--------------------------------------------------------------

>72267_72267_15_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000507093_USP33_chr1_78205103_ENST00000370793_length(amino acids)=970AA_BP=114
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI
PSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK
SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAEN
ENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLST
PQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGK
EDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKF
CKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQ
SVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDL
VLMLPQNIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGP

--------------------------------------------------------------

>72267_72267_16_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000507093_USP33_chr1_78205103_ENST00000370794_length(amino acids)=970AA_BP=114
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI
PSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK
SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAEN
ENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLST
PQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGK
EDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKF
CKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQ
SVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDL
VLMLPQNIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGP

--------------------------------------------------------------

>72267_72267_17_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000509018_USP33_chr1_78205103_ENST00000357428_length(amino acids)=970AA_BP=114
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI
PSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK
SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAEN
ENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLST
PQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGK
EDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKF
CKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQ
SVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDL
VLMLPQNIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGP

--------------------------------------------------------------

>72267_72267_18_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000509018_USP33_chr1_78205103_ENST00000370792_length(amino acids)=856AA_BP=114
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI
PSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK
SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAEN
ENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLST
PQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGK
EDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPE
ILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSES
TVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNI

--------------------------------------------------------------

>72267_72267_19_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000509018_USP33_chr1_78205103_ENST00000370793_length(amino acids)=970AA_BP=114
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI
PSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK
SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAEN
ENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLST
PQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGK
EDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKF
CKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQ
SVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDL
VLMLPQNIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGP

--------------------------------------------------------------

>72267_72267_20_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000509018_USP33_chr1_78205103_ENST00000370794_length(amino acids)=970AA_BP=114
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI
PSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK
SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAEN
ENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLST
PQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGK
EDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKF
CKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQ
SVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDL
VLMLPQNIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGP

--------------------------------------------------------------

>72267_72267_21_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000510071_USP33_chr1_78205103_ENST00000357428_length(amino acids)=970AA_BP=114
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI
PSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK
SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAEN
ENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLST
PQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGK
EDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKF
CKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQ
SVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDL
VLMLPQNIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGP

--------------------------------------------------------------

>72267_72267_22_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000510071_USP33_chr1_78205103_ENST00000370792_length(amino acids)=856AA_BP=114
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI
PSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK
SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAEN
ENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLST
PQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGK
EDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPE
ILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSES
TVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNI

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>72267_72267_23_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000510071_USP33_chr1_78205103_ENST00000370793_length(amino acids)=970AA_BP=114
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI
PSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK
SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAEN
ENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLST
PQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGK
EDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKF
CKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQ
SVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDL
VLMLPQNIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGP

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>72267_72267_24_RAPGEF6-USP33_RAPGEF6_chr5_130897670_ENST00000510071_USP33_chr1_78205103_ENST00000370794_length(amino acids)=970AA_BP=114
MRSTRAVAMNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSV
LVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKI
PSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK
SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAEN
ENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLST
PQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGK
EDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKF
CKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQ
SVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDL
VLMLPQNIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGP

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:130897670/chr1:78205103)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUSP33chr5:130897670chr1:78205103ENST00000357428324185_71597.0943.0DomainNote=USP
TgeneUSP33chr5:130897670chr1:78205103ENST00000357428324717_81097.0943.0DomainDUSP 1
TgeneUSP33chr5:130897670chr1:78205103ENST00000357428324818_92197.0943.0DomainDUSP 2
TgeneUSP33chr5:130897670chr1:78205103ENST00000370792422185_71597.0829.0DomainNote=USP
TgeneUSP33chr5:130897670chr1:78205103ENST00000370792422717_81097.0829.0DomainDUSP 1
TgeneUSP33chr5:130897670chr1:78205103ENST00000370792422818_92197.0829.0DomainDUSP 2
TgeneUSP33chr5:130897670chr1:78205103ENST00000370793425185_71597.0943.0DomainNote=USP
TgeneUSP33chr5:130897670chr1:78205103ENST00000370793425717_81097.0943.0DomainDUSP 1
TgeneUSP33chr5:130897670chr1:78205103ENST00000370793425818_92197.0943.0DomainDUSP 2
TgeneUSP33chr5:130897670chr1:78205103ENST00000370794324185_71566.0912.0DomainNote=USP
TgeneUSP33chr5:130897670chr1:78205103ENST00000370794324717_81066.0912.0DomainDUSP 1
TgeneUSP33chr5:130897670chr1:78205103ENST00000370794324818_92166.0912.0DomainDUSP 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000296859-5291229_1440117.01610.0Compositional biasNote=Ser-rich
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000307984-5291229_1440117.01510.0Compositional biasNote=Ser-rich
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000308008-5251229_1440117.01392.0Compositional biasNote=Ser-rich
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000507093-5281229_1440117.01505.0Compositional biasNote=Ser-rich
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000509018-5281229_1440117.01602.0Compositional biasNote=Ser-rich
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000510071-5181229_1440117.0828.0Compositional biasNote=Ser-rich
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000296859-529412_526117.01610.0DomainN-terminal Ras-GEF
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000296859-529530_615117.01610.0DomainPDZ
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000296859-529749_835117.01610.0DomainRas-associating
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000296859-529860_1088117.01610.0DomainRas-GEF
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000307984-529412_526117.01510.0DomainN-terminal Ras-GEF
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000307984-529530_615117.01510.0DomainPDZ
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000307984-529749_835117.01510.0DomainRas-associating
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000307984-529860_1088117.01510.0DomainRas-GEF
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000308008-525412_526117.01392.0DomainN-terminal Ras-GEF
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000308008-525530_615117.01392.0DomainPDZ
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000308008-525749_835117.01392.0DomainRas-associating
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000308008-525860_1088117.01392.0DomainRas-GEF
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000507093-528412_526117.01505.0DomainN-terminal Ras-GEF
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000507093-528530_615117.01505.0DomainPDZ
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000507093-528749_835117.01505.0DomainRas-associating
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000507093-528860_1088117.01505.0DomainRas-GEF
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000509018-528412_526117.01602.0DomainN-terminal Ras-GEF
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000509018-528530_615117.01602.0DomainPDZ
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000509018-528749_835117.01602.0DomainRas-associating
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000509018-528860_1088117.01602.0DomainRas-GEF
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000510071-518412_526117.0828.0DomainN-terminal Ras-GEF
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000510071-518530_615117.0828.0DomainPDZ
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000510071-518749_835117.0828.0DomainRas-associating
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000510071-518860_1088117.0828.0DomainRas-GEF
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000296859-529280_399117.01610.0Nucleotide bindingNote=cNMP
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000307984-529280_399117.01510.0Nucleotide bindingNote=cNMP
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000308008-525280_399117.01392.0Nucleotide bindingNote=cNMP
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000507093-528280_399117.01505.0Nucleotide bindingNote=cNMP
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000509018-528280_399117.01602.0Nucleotide bindingNote=cNMP
HgeneRAPGEF6chr5:130897670chr1:78205103ENST00000510071-518280_399117.0828.0Nucleotide bindingNote=cNMP
TgeneUSP33chr5:130897670chr1:78205103ENST0000035742832459_12397.0943.0Zinc fingerUBP-type
TgeneUSP33chr5:130897670chr1:78205103ENST0000037079242259_12397.0829.0Zinc fingerUBP-type
TgeneUSP33chr5:130897670chr1:78205103ENST0000037079342559_12397.0943.0Zinc fingerUBP-type
TgeneUSP33chr5:130897670chr1:78205103ENST0000037079432459_12366.0912.0Zinc fingerUBP-type


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RAPGEF6
USP33


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to RAPGEF6-USP33


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RAPGEF6-USP33


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource