UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:RASSF3-ITGA7

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RASSF3-ITGA7
FusionPDB ID: 72492
FusionGDB2.0 ID: 72492
HgeneTgene
Gene symbol

RASSF3

ITGA7

Gene ID

283349

3679

Gene nameRas association domain family member 3integrin subunit alpha 7
SynonymsRASSF5-
Cytomap

12q14.2

12q13.2

Type of geneprotein-codingprotein-coding
Descriptionras association domain-containing protein 3Ras association (RalGDS/AF-6) domain family 3Ras association (RalGDS/AF-6) domain family member 3integrin alpha-7integrin alpha 7 chain
Modification date2020032720200328
UniProtAcc.

Q13683

Ensembl transtripts involved in fusion geneENST idsENST00000540088, ENST00000336061, 
ENST00000542104, 		ENST00000257879, 
ENST00000257880, ENST00000347027, 
ENST00000394229, ENST00000394230, 
ENST00000452168, ENST00000553804, 
ENST00000555728, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 7 X 12=15125 X 3 X 5=75
# samples 185
** MAII scorelog2(18/1512*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RASSF3 [Title/Abstract] AND ITGA7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RASSF3(65004523)-ITGA7(56079072), # samples:3
Anticipated loss of major functional domain due to fusion event.RASSF3-ITGA7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RASSF3-ITGA7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RASSF3-ITGA7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RASSF3-ITGA7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RASSF3-ITGA7 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
RASSF3-ITGA7 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
RASSF3-ITGA7 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RASSF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ITGA7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-GN-A26D-06ARASSF3chr12

65004523

-ITGA7chr12

56079072

-
ChimerDB4SKCMTCGA-GN-A26D-06ARASSF3chr12

65004523

+ITGA7chr12

56079072

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000336061RASSF3chr1265004523+ENST00000553804ITGA7chr1256079072-8751546421214
ENST00000336061RASSF3chr1265004523+ENST00000347027ITGA7chr1256079072-8711546421214
ENST00000336061RASSF3chr1265004523+ENST00000452168ITGA7chr1256079072-8711546421214
ENST00000542104RASSF3chr1265004523+ENST00000553804ITGA7chr1256079072-9522317190240
ENST00000542104RASSF3chr1265004523+ENST00000347027ITGA7chr1256079072-9482317190240
ENST00000542104RASSF3chr1265004523+ENST00000452168ITGA7chr1256079072-9482317190240

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336061ENST00000553804RASSF3chr1265004523+ITGA7chr1256079072-0.099831680.9001683
ENST00000336061ENST00000347027RASSF3chr1265004523+ITGA7chr1256079072-0.1058051660.89419484
ENST00000336061ENST00000452168RASSF3chr1265004523+ITGA7chr1256079072-0.1058051660.89419484
ENST00000542104ENST00000553804RASSF3chr1265004523+ITGA7chr1256079072-0.179550630.82044935
ENST00000542104ENST00000347027RASSF3chr1265004523+ITGA7chr1256079072-0.180610220.8193898
ENST00000542104ENST00000452168RASSF3chr1265004523+ITGA7chr1256079072-0.180610220.8193898

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>72492_72492_1_RASSF3-ITGA7_RASSF3_chr12_65004523_ENST00000336061_ITGA7_chr12_56079072_ENST00000347027_length(amino acids)=214AA_BP=1
MHQDTPALLTLPHGPVPDLPTLISQHSKGKLGGRSSCGWERSVPLRKPILPNLDATPAAHSTLFIPRSHLWGRDGGQPQARLGHGNLGGA
WPWMPIGAQLGMPVSSQDGVCIRALPPGAAPVVPQDGARLLLLELLSVFPRNLHRMVLGHGGLGVLRPFEESHLLAGAGLALGRSPEEGG

--------------------------------------------------------------

>72492_72492_2_RASSF3-ITGA7_RASSF3_chr12_65004523_ENST00000336061_ITGA7_chr12_56079072_ENST00000452168_length(amino acids)=214AA_BP=1
MHQDTPALLTLPHGPVPDLPTLISQHSKGKLGGRSSCGWERSVPLRKPILPNLDATPAAHSTLFIPRSHLWGRDGGQPQARLGHGNLGGA
WPWMPIGAQLGMPVSSQDGVCIRALPPGAAPVVPQDGARLLLLELLSVFPRNLHRMVLGHGGLGVLRPFEESHLLAGAGLALGRSPEEGG

--------------------------------------------------------------

>72492_72492_3_RASSF3-ITGA7_RASSF3_chr12_65004523_ENST00000336061_ITGA7_chr12_56079072_ENST00000553804_length(amino acids)=214AA_BP=1
MHQDTPALLTLPHGPVPDLPTLISQHSKGKLGGRSSCGWERSVPLRKPILPNLDATPAAHSTLFIPRSHLWGRDGGQPQARLGHGNLGGA
WPWMPIGAQLGMPVSSQDGVCIRALPPGAAPVVPQDGARLLLLELLSVFPRNLHRMVLGHGGLGVLRPFEESHLLAGAGLALGRSPEEGG

--------------------------------------------------------------

>72492_72492_4_RASSF3-ITGA7_RASSF3_chr12_65004523_ENST00000542104_ITGA7_chr12_56079072_ENST00000347027_length(amino acids)=240AA_BP=1
MHQDTPALLTLPHGPVPDLPTLISQHSKGKLGGRSSCGWERSVPLRKPILPNLDATPAAHSTLFIPRSHLWGRDGGQPQARLGHGNLGGA
WPWMPIGAQLGMPVSSQDGVCIRALPPGAAPVVPQDGARLLLLELLSVFPRNLHRMVLGHGGLGVLRPFEESHLLAGAGLALGRSPEEGG

--------------------------------------------------------------

>72492_72492_5_RASSF3-ITGA7_RASSF3_chr12_65004523_ENST00000542104_ITGA7_chr12_56079072_ENST00000452168_length(amino acids)=240AA_BP=1
MHQDTPALLTLPHGPVPDLPTLISQHSKGKLGGRSSCGWERSVPLRKPILPNLDATPAAHSTLFIPRSHLWGRDGGQPQARLGHGNLGGA
WPWMPIGAQLGMPVSSQDGVCIRALPPGAAPVVPQDGARLLLLELLSVFPRNLHRMVLGHGGLGVLRPFEESHLLAGAGLALGRSPEEGG

--------------------------------------------------------------

>72492_72492_6_RASSF3-ITGA7_RASSF3_chr12_65004523_ENST00000542104_ITGA7_chr12_56079072_ENST00000553804_length(amino acids)=240AA_BP=1
MHQDTPALLTLPHGPVPDLPTLISQHSKGKLGGRSSCGWERSVPLRKPILPNLDATPAAHSTLFIPRSHLWGRDGGQPQARLGHGNLGGA
WPWMPIGAQLGMPVSSQDGVCIRALPPGAAPVVPQDGARLLLLELLSVFPRNLHRMVLGHGGLGVLRPFEESHLLAGAGLALGRSPEEGG

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:65004523/chr12:56079072)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ITGA7

Q13683

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. {ECO:0000250, ECO:0000269|PubMed:10694445, ECO:0000269|PubMed:17641293, ECO:0000269|PubMed:9307969}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneITGA7chr12:65004523chr12:56079072ENST0000025787923251107_11111061.01138.0MotifNote=GFFKR motif
TgeneITGA7chr12:65004523chr12:56079072ENST0000045216823251107_1111968.01045.0MotifNote=GFFKR motif
TgeneITGA7chr12:65004523chr12:56079072ENST0000055380423251107_11111065.01142.0MotifNote=GFFKR motif
TgeneITGA7chr12:65004523chr12:56079072ENST0000055572824261107_11111105.01182.0MotifNote=GFFKR motif
TgeneITGA7chr12:65004523chr12:56079072ENST0000025787923251157_11761061.01138.0RegionNote=3 X 4 AA repeats of D-X-H-P
TgeneITGA7chr12:65004523chr12:56079072ENST0000025788025271157_11761142.66666666666671163.0RegionNote=3 X 4 AA repeats of D-X-H-P
TgeneITGA7chr12:65004523chr12:56079072ENST0000045216823251157_1176968.01045.0RegionNote=3 X 4 AA repeats of D-X-H-P
TgeneITGA7chr12:65004523chr12:56079072ENST0000055380423251157_11761065.01142.0RegionNote=3 X 4 AA repeats of D-X-H-P
TgeneITGA7chr12:65004523chr12:56079072ENST0000055572824261157_11761105.01182.0RegionNote=3 X 4 AA repeats of D-X-H-P
TgeneITGA7chr12:65004523chr12:56079072ENST0000025787923251157_11601061.01138.0RepeatNote=1
TgeneITGA7chr12:65004523chr12:56079072ENST0000025787923251165_11681061.01138.0RepeatNote=2
TgeneITGA7chr12:65004523chr12:56079072ENST0000025787923251173_11761061.01138.0RepeatNote=3
TgeneITGA7chr12:65004523chr12:56079072ENST0000025788025271157_11601142.66666666666671163.0RepeatNote=1
TgeneITGA7chr12:65004523chr12:56079072ENST0000025788025271165_11681142.66666666666671163.0RepeatNote=2
TgeneITGA7chr12:65004523chr12:56079072ENST0000025788025271173_11761142.66666666666671163.0RepeatNote=3
TgeneITGA7chr12:65004523chr12:56079072ENST0000045216823251157_1160968.01045.0RepeatNote=1
TgeneITGA7chr12:65004523chr12:56079072ENST0000045216823251165_1168968.01045.0RepeatNote=2
TgeneITGA7chr12:65004523chr12:56079072ENST0000045216823251173_1176968.01045.0RepeatNote=3
TgeneITGA7chr12:65004523chr12:56079072ENST0000055380423251157_11601065.01142.0RepeatNote=1
TgeneITGA7chr12:65004523chr12:56079072ENST0000055380423251165_11681065.01142.0RepeatNote=2
TgeneITGA7chr12:65004523chr12:56079072ENST0000055380423251173_11761065.01142.0RepeatNote=3
TgeneITGA7chr12:65004523chr12:56079072ENST0000055572824261157_11601105.01182.0RepeatNote=1
TgeneITGA7chr12:65004523chr12:56079072ENST0000055572824261165_11681105.01182.0RepeatNote=2
TgeneITGA7chr12:65004523chr12:56079072ENST0000055572824261173_11761105.01182.0RepeatNote=3
TgeneITGA7chr12:65004523chr12:56079072ENST0000025787923251104_11811061.01138.0Topological domainCytoplasmic
TgeneITGA7chr12:65004523chr12:56079072ENST0000045216823251104_1181968.01045.0Topological domainCytoplasmic
TgeneITGA7chr12:65004523chr12:56079072ENST0000055380423251104_11811065.01142.0Topological domainCytoplasmic
TgeneITGA7chr12:65004523chr12:56079072ENST0000055572824261104_11811105.01182.0Topological domainCytoplasmic
TgeneITGA7chr12:65004523chr12:56079072ENST0000025787923251083_11031061.01138.0TransmembraneHelical
TgeneITGA7chr12:65004523chr12:56079072ENST0000045216823251083_1103968.01045.0TransmembraneHelical
TgeneITGA7chr12:65004523chr12:56079072ENST0000055380423251083_11031065.01142.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRASSF3chr12:65004523chr12:56079072ENST00000336061+26187_23437.0239.0DomainSARAH
HgeneRASSF3chr12:65004523chr12:56079072ENST00000336061+2679_18637.0239.0DomainRas-associating
HgeneRASSF3chr12:65004523chr12:56079072ENST00000542104+15187_23437.0239.0DomainSARAH
HgeneRASSF3chr12:65004523chr12:56079072ENST00000542104+1579_18637.0239.0DomainRas-associating
TgeneITGA7chr12:65004523chr12:56079072ENST000002578792325372_3801061.01138.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000002578792325434_4421061.01138.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000002578792325492_5001061.01138.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000002578802527372_3801142.66666666666671163.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000002578802527434_4421142.66666666666671163.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000002578802527492_5001142.66666666666671163.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000004521682325372_380968.01045.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000004521682325434_442968.01045.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000004521682325492_500968.01045.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000005538042325372_3801065.01142.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000005538042325434_4421065.01142.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000005538042325492_5001065.01142.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000005557282426372_3801105.01182.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000005557282426434_4421105.01182.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000005557282426492_5001105.01182.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:65004523chr12:56079072ENST000002578792325953_9581061.01138.0Compositional biasNote=Poly-Arg
TgeneITGA7chr12:65004523chr12:56079072ENST000002578802527953_9581142.66666666666671163.0Compositional biasNote=Poly-Arg
TgeneITGA7chr12:65004523chr12:56079072ENST000004521682325953_958968.01045.0Compositional biasNote=Poly-Arg
TgeneITGA7chr12:65004523chr12:56079072ENST000005538042325953_9581065.01142.0Compositional biasNote=Poly-Arg
TgeneITGA7chr12:65004523chr12:56079072ENST000005557282426953_9581105.01182.0Compositional biasNote=Poly-Arg
TgeneITGA7chr12:65004523chr12:56079072ENST0000025788025271107_11111142.66666666666671163.0MotifNote=GFFKR motif
TgeneITGA7chr12:65004523chr12:56079072ENST000002578792325110_1751061.01138.0RepeatFG-GAP 2
TgeneITGA7chr12:65004523chr12:56079072ENST000002578792325185_2381061.01138.0RepeatFG-GAP 3
TgeneITGA7chr12:65004523chr12:56079072ENST000002578792325292_3491061.01138.0RepeatFG-GAP 4
TgeneITGA7chr12:65004523chr12:56079072ENST000002578792325350_4111061.01138.0RepeatFG-GAP 5
TgeneITGA7chr12:65004523chr12:56079072ENST00000257879232535_1031061.01138.0RepeatFG-GAP 1
TgeneITGA7chr12:65004523chr12:56079072ENST000002578792325412_4671061.01138.0RepeatFG-GAP 6
TgeneITGA7chr12:65004523chr12:56079072ENST000002578792325471_5301061.01138.0RepeatFG-GAP 7
TgeneITGA7chr12:65004523chr12:56079072ENST000002578802527110_1751142.66666666666671163.0RepeatFG-GAP 2
TgeneITGA7chr12:65004523chr12:56079072ENST000002578802527185_2381142.66666666666671163.0RepeatFG-GAP 3
TgeneITGA7chr12:65004523chr12:56079072ENST000002578802527292_3491142.66666666666671163.0RepeatFG-GAP 4
TgeneITGA7chr12:65004523chr12:56079072ENST000002578802527350_4111142.66666666666671163.0RepeatFG-GAP 5
TgeneITGA7chr12:65004523chr12:56079072ENST00000257880252735_1031142.66666666666671163.0RepeatFG-GAP 1
TgeneITGA7chr12:65004523chr12:56079072ENST000002578802527412_4671142.66666666666671163.0RepeatFG-GAP 6
TgeneITGA7chr12:65004523chr12:56079072ENST000002578802527471_5301142.66666666666671163.0RepeatFG-GAP 7
TgeneITGA7chr12:65004523chr12:56079072ENST000004521682325110_175968.01045.0RepeatFG-GAP 2
TgeneITGA7chr12:65004523chr12:56079072ENST000004521682325185_238968.01045.0RepeatFG-GAP 3
TgeneITGA7chr12:65004523chr12:56079072ENST000004521682325292_349968.01045.0RepeatFG-GAP 4
TgeneITGA7chr12:65004523chr12:56079072ENST000004521682325350_411968.01045.0RepeatFG-GAP 5
TgeneITGA7chr12:65004523chr12:56079072ENST00000452168232535_103968.01045.0RepeatFG-GAP 1
TgeneITGA7chr12:65004523chr12:56079072ENST000004521682325412_467968.01045.0RepeatFG-GAP 6
TgeneITGA7chr12:65004523chr12:56079072ENST000004521682325471_530968.01045.0RepeatFG-GAP 7
TgeneITGA7chr12:65004523chr12:56079072ENST000005538042325110_1751065.01142.0RepeatFG-GAP 2
TgeneITGA7chr12:65004523chr12:56079072ENST000005538042325185_2381065.01142.0RepeatFG-GAP 3
TgeneITGA7chr12:65004523chr12:56079072ENST000005538042325292_3491065.01142.0RepeatFG-GAP 4
TgeneITGA7chr12:65004523chr12:56079072ENST000005538042325350_4111065.01142.0RepeatFG-GAP 5
TgeneITGA7chr12:65004523chr12:56079072ENST00000553804232535_1031065.01142.0RepeatFG-GAP 1
TgeneITGA7chr12:65004523chr12:56079072ENST000005538042325412_4671065.01142.0RepeatFG-GAP 6
TgeneITGA7chr12:65004523chr12:56079072ENST000005538042325471_5301065.01142.0RepeatFG-GAP 7
TgeneITGA7chr12:65004523chr12:56079072ENST000005557282426110_1751105.01182.0RepeatFG-GAP 2
TgeneITGA7chr12:65004523chr12:56079072ENST000005557282426185_2381105.01182.0RepeatFG-GAP 3
TgeneITGA7chr12:65004523chr12:56079072ENST000005557282426292_3491105.01182.0RepeatFG-GAP 4
TgeneITGA7chr12:65004523chr12:56079072ENST000005557282426350_4111105.01182.0RepeatFG-GAP 5
TgeneITGA7chr12:65004523chr12:56079072ENST00000555728242635_1031105.01182.0RepeatFG-GAP 1
TgeneITGA7chr12:65004523chr12:56079072ENST000005557282426412_4671105.01182.0RepeatFG-GAP 6
TgeneITGA7chr12:65004523chr12:56079072ENST000005557282426471_5301105.01182.0RepeatFG-GAP 7
TgeneITGA7chr12:65004523chr12:56079072ENST00000257879232534_10821061.01138.0Topological domainExtracellular
TgeneITGA7chr12:65004523chr12:56079072ENST0000025788025271104_11811142.66666666666671163.0Topological domainCytoplasmic
TgeneITGA7chr12:65004523chr12:56079072ENST00000257880252734_10821142.66666666666671163.0Topological domainExtracellular
TgeneITGA7chr12:65004523chr12:56079072ENST00000452168232534_1082968.01045.0Topological domainExtracellular
TgeneITGA7chr12:65004523chr12:56079072ENST00000553804232534_10821065.01142.0Topological domainExtracellular
TgeneITGA7chr12:65004523chr12:56079072ENST00000555728242634_10821105.01182.0Topological domainExtracellular
TgeneITGA7chr12:65004523chr12:56079072ENST0000025788025271083_11031142.66666666666671163.0TransmembraneHelical
TgeneITGA7chr12:65004523chr12:56079072ENST0000055572824261083_11031105.01182.0TransmembraneHelical


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RASSF3
ITGA7


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to RASSF3-ITGA7


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to RASSF3-ITGA7


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource