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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:RBMS2-NACA

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: RBMS2-NACA
	FusionPDB ID: 73026
	FusionGDB2.0 ID: 73026
		Hgene	Tgene
	Gene symbol	RBMS2	NACA
	Gene ID	5939	4666
	Gene name	RNA binding motif single stranded interacting protein 2	nascent polypeptide associated complex subunit alpha
	Synonyms	SCR3	HSD48\|NAC-alpha\|NACA1\|skNAC
	Cytomap	12q13.3	12q13.3
	Type of gene	protein-coding	protein-coding
	Description	RNA-binding motif, single-stranded-interacting protein 2suppressor of CDC2 with RNA-binding motif 3	nascent polypeptide-associated complex subunit alphaalpha-NAC, muscle-specific formnascent-polypeptide-associated complex alpha polypeptide
	Modification date	20200313	20200313
	UniProtAcc	.	Q9H009
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000262031, ENST00000542360, ENST00000550726, ENST00000549945, ENST00000552247,	ENST00000551793, ENST00000356769, ENST00000393891, ENST00000454682, ENST00000546392, ENST00000548563, ENST00000550952, ENST00000552540,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 7 X 6=336	15 X 16 X 4=960
	# samples	9	15
	** MAII score	log2(9/336*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/960*10)=-2.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: RBMS2 [Title/Abstract] AND NACA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	RBMS2(56980710)-NACA(57106974), # samples:1
Anticipated loss of major functional domain due to fusion event.	RBMS2-NACA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RBMS2-NACA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RBMS2-NACA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RBMS2-NACA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across RBMS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NACA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-BA-5152-01A	RBMS2	chr12	56980710	+	NACA	chr12	57106974	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000262031	RBMS2	chr12	56980710	+	ENST00000454682	NACA	chr12	57106974	-	1423	1046	95	1312	405
ENST00000262031	RBMS2	chr12	56980710	+	ENST00000550952	NACA	chr12	57106974	-	1418	1046	95	1312	405
ENST00000262031	RBMS2	chr12	56980710	+	ENST00000356769	NACA	chr12	57106974	-	1418	1046	95	1312	405
ENST00000262031	RBMS2	chr12	56980710	+	ENST00000552540	NACA	chr12	57106974	-	1416	1046	95	1312	405
ENST00000262031	RBMS2	chr12	56980710	+	ENST00000393891	NACA	chr12	57106974	-	1416	1046	95	1312	405
ENST00000262031	RBMS2	chr12	56980710	+	ENST00000548563	NACA	chr12	57106974	-	1411	1046	95	1312	405
ENST00000262031	RBMS2	chr12	56980710	+	ENST00000546392	NACA	chr12	57106974	-	1347	1046	95	1312	405
ENST00000550726	RBMS2	chr12	56980710	+	ENST00000454682	NACA	chr12	57106974	-	1186	809	65	1075	336
ENST00000550726	RBMS2	chr12	56980710	+	ENST00000550952	NACA	chr12	57106974	-	1181	809	65	1075	336
ENST00000550726	RBMS2	chr12	56980710	+	ENST00000356769	NACA	chr12	57106974	-	1181	809	65	1075	336
ENST00000550726	RBMS2	chr12	56980710	+	ENST00000552540	NACA	chr12	57106974	-	1179	809	65	1075	336
ENST00000550726	RBMS2	chr12	56980710	+	ENST00000393891	NACA	chr12	57106974	-	1179	809	65	1075	336
ENST00000550726	RBMS2	chr12	56980710	+	ENST00000548563	NACA	chr12	57106974	-	1174	809	65	1075	336
ENST00000550726	RBMS2	chr12	56980710	+	ENST00000546392	NACA	chr12	57106974	-	1110	809	65	1075	336
ENST00000542360	RBMS2	chr12	56980710	+	ENST00000454682	NACA	chr12	57106974	-	1126	749	65	1015	316
ENST00000542360	RBMS2	chr12	56980710	+	ENST00000550952	NACA	chr12	57106974	-	1121	749	65	1015	316
ENST00000542360	RBMS2	chr12	56980710	+	ENST00000356769	NACA	chr12	57106974	-	1121	749	65	1015	316
ENST00000542360	RBMS2	chr12	56980710	+	ENST00000552540	NACA	chr12	57106974	-	1119	749	65	1015	316
ENST00000542360	RBMS2	chr12	56980710	+	ENST00000393891	NACA	chr12	57106974	-	1119	749	65	1015	316
ENST00000542360	RBMS2	chr12	56980710	+	ENST00000548563	NACA	chr12	57106974	-	1114	749	65	1015	316
ENST00000542360	RBMS2	chr12	56980710	+	ENST00000546392	NACA	chr12	57106974	-	1050	749	65	1015	316

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000262031	ENST00000454682	RBMS2	chr12	56980710	+	NACA	chr12	57106974	-	0.003161345	0.9968387
ENST00000262031	ENST00000550952	RBMS2	chr12	56980710	+	NACA	chr12	57106974	-	0.003088031	0.9969119
ENST00000262031	ENST00000356769	RBMS2	chr12	56980710	+	NACA	chr12	57106974	-	0.003088031	0.9969119
ENST00000262031	ENST00000552540	RBMS2	chr12	56980710	+	NACA	chr12	57106974	-	0.003137831	0.9968622
ENST00000262031	ENST00000393891	RBMS2	chr12	56980710	+	NACA	chr12	57106974	-	0.003137831	0.9968622
ENST00000262031	ENST00000548563	RBMS2	chr12	56980710	+	NACA	chr12	57106974	-	0.003252128	0.99674785
ENST00000262031	ENST00000546392	RBMS2	chr12	56980710	+	NACA	chr12	57106974	-	0.00361768	0.99638236
ENST00000550726	ENST00000454682	RBMS2	chr12	56980710	+	NACA	chr12	57106974	-	0.001935871	0.9980641
ENST00000550726	ENST00000550952	RBMS2	chr12	56980710	+	NACA	chr12	57106974	-	0.001912669	0.99808735
ENST00000550726	ENST00000356769	RBMS2	chr12	56980710	+	NACA	chr12	57106974	-	0.001912669	0.99808735
ENST00000550726	ENST00000552540	RBMS2	chr12	56980710	+	NACA	chr12	57106974	-	0.001924287	0.9980757
ENST00000550726	ENST00000393891	RBMS2	chr12	56980710	+	NACA	chr12	57106974	-	0.001924287	0.9980757
ENST00000550726	ENST00000548563	RBMS2	chr12	56980710	+	NACA	chr12	57106974	-	0.002022624	0.99797744
ENST00000550726	ENST00000546392	RBMS2	chr12	56980710	+	NACA	chr12	57106974	-	0.002143831	0.9978562
ENST00000542360	ENST00000454682	RBMS2	chr12	56980710	+	NACA	chr12	57106974	-	0.002942334	0.9970577
ENST00000542360	ENST00000550952	RBMS2	chr12	56980710	+	NACA	chr12	57106974	-	0.002902977	0.997097
ENST00000542360	ENST00000356769	RBMS2	chr12	56980710	+	NACA	chr12	57106974	-	0.002902977	0.997097
ENST00000542360	ENST00000552540	RBMS2	chr12	56980710	+	NACA	chr12	57106974	-	0.003021063	0.996979
ENST00000542360	ENST00000393891	RBMS2	chr12	56980710	+	NACA	chr12	57106974	-	0.003021063	0.996979
ENST00000542360	ENST00000548563	RBMS2	chr12	56980710	+	NACA	chr12	57106974	-	0.003210604	0.9967894
ENST00000542360	ENST00000546392	RBMS2	chr12	56980710	+	NACA	chr12	57106974	-	0.003274551	0.99672544

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>73026_73026_1_RBMS2-NACA_RBMS2_chr12_56980710_ENST00000262031_NACA_chr12_57106974_ENST00000356769_length(amino acids)=405AA_BP=317
MLLSVTSRPGISTFGYNRNNKKPYVSLAQQMAPPSPSNSTPNSSSGSNGNDQLSKTNLYIRGLQPGTTDQDLVKLCQPYGKIVSTKAILD
KTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFGQVISTRILRDTSGTSRGVGFA
RMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNADMGVMALTYDPTTALQNGFYPAPYNITP
NRMLAQSALSPYLSSPVSSYQRVTQTSPLQVPNPSWMHHHSYLMQPSIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEEE

--------------------------------------------------------------

>73026_73026_2_RBMS2-NACA_RBMS2_chr12_56980710_ENST00000262031_NACA_chr12_57106974_ENST00000393891_length(amino acids)=405AA_BP=317
MLLSVTSRPGISTFGYNRNNKKPYVSLAQQMAPPSPSNSTPNSSSGSNGNDQLSKTNLYIRGLQPGTTDQDLVKLCQPYGKIVSTKAILD
KTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFGQVISTRILRDTSGTSRGVGFA
RMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNADMGVMALTYDPTTALQNGFYPAPYNITP
NRMLAQSALSPYLSSPVSSYQRVTQTSPLQVPNPSWMHHHSYLMQPSIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEEE

--------------------------------------------------------------

>73026_73026_3_RBMS2-NACA_RBMS2_chr12_56980710_ENST00000262031_NACA_chr12_57106974_ENST00000454682_length(amino acids)=405AA_BP=317
MLLSVTSRPGISTFGYNRNNKKPYVSLAQQMAPPSPSNSTPNSSSGSNGNDQLSKTNLYIRGLQPGTTDQDLVKLCQPYGKIVSTKAILD
KTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFGQVISTRILRDTSGTSRGVGFA
RMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNADMGVMALTYDPTTALQNGFYPAPYNITP
NRMLAQSALSPYLSSPVSSYQRVTQTSPLQVPNPSWMHHHSYLMQPSIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEEE

--------------------------------------------------------------

>73026_73026_4_RBMS2-NACA_RBMS2_chr12_56980710_ENST00000262031_NACA_chr12_57106974_ENST00000546392_length(amino acids)=405AA_BP=317
MLLSVTSRPGISTFGYNRNNKKPYVSLAQQMAPPSPSNSTPNSSSGSNGNDQLSKTNLYIRGLQPGTTDQDLVKLCQPYGKIVSTKAILD
KTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFGQVISTRILRDTSGTSRGVGFA
RMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNADMGVMALTYDPTTALQNGFYPAPYNITP
NRMLAQSALSPYLSSPVSSYQRVTQTSPLQVPNPSWMHHHSYLMQPSIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEEE

--------------------------------------------------------------

>73026_73026_5_RBMS2-NACA_RBMS2_chr12_56980710_ENST00000262031_NACA_chr12_57106974_ENST00000548563_length(amino acids)=405AA_BP=317
MLLSVTSRPGISTFGYNRNNKKPYVSLAQQMAPPSPSNSTPNSSSGSNGNDQLSKTNLYIRGLQPGTTDQDLVKLCQPYGKIVSTKAILD
KTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFGQVISTRILRDTSGTSRGVGFA
RMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNADMGVMALTYDPTTALQNGFYPAPYNITP
NRMLAQSALSPYLSSPVSSYQRVTQTSPLQVPNPSWMHHHSYLMQPSIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEEE

--------------------------------------------------------------

>73026_73026_6_RBMS2-NACA_RBMS2_chr12_56980710_ENST00000262031_NACA_chr12_57106974_ENST00000550952_length(amino acids)=405AA_BP=317
MLLSVTSRPGISTFGYNRNNKKPYVSLAQQMAPPSPSNSTPNSSSGSNGNDQLSKTNLYIRGLQPGTTDQDLVKLCQPYGKIVSTKAILD
KTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFGQVISTRILRDTSGTSRGVGFA
RMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNADMGVMALTYDPTTALQNGFYPAPYNITP
NRMLAQSALSPYLSSPVSSYQRVTQTSPLQVPNPSWMHHHSYLMQPSIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEEE

--------------------------------------------------------------

>73026_73026_7_RBMS2-NACA_RBMS2_chr12_56980710_ENST00000262031_NACA_chr12_57106974_ENST00000552540_length(amino acids)=405AA_BP=317
MLLSVTSRPGISTFGYNRNNKKPYVSLAQQMAPPSPSNSTPNSSSGSNGNDQLSKTNLYIRGLQPGTTDQDLVKLCQPYGKIVSTKAILD
KTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFGQVISTRILRDTSGTSRGVGFA
RMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNADMGVMALTYDPTTALQNGFYPAPYNITP
NRMLAQSALSPYLSSPVSSYQRVTQTSPLQVPNPSWMHHHSYLMQPSIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEEE

--------------------------------------------------------------

>73026_73026_8_RBMS2-NACA_RBMS2_chr12_56980710_ENST00000542360_NACA_chr12_57106974_ENST00000356769_length(amino acids)=316AA_BP=57
MATIETTRRYGKIVSTKAILDKTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKAGVQWRDLDSLQPLPPRFKRFSHLCLLSSWD
YRMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNADMGVMALTYDPTTALQNGFYPAPYNIT
PNRMLAQSALSPYLSSPVSSYQRVTQTSPLQVPNPSWMHHHSYLMQPSIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEE

--------------------------------------------------------------

>73026_73026_9_RBMS2-NACA_RBMS2_chr12_56980710_ENST00000542360_NACA_chr12_57106974_ENST00000393891_length(amino acids)=316AA_BP=57
MATIETTRRYGKIVSTKAILDKTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKAGVQWRDLDSLQPLPPRFKRFSHLCLLSSWD
YRMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNADMGVMALTYDPTTALQNGFYPAPYNIT
PNRMLAQSALSPYLSSPVSSYQRVTQTSPLQVPNPSWMHHHSYLMQPSIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEE

--------------------------------------------------------------

>73026_73026_10_RBMS2-NACA_RBMS2_chr12_56980710_ENST00000542360_NACA_chr12_57106974_ENST00000454682_length(amino acids)=316AA_BP=57
MATIETTRRYGKIVSTKAILDKTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKAGVQWRDLDSLQPLPPRFKRFSHLCLLSSWD
YRMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNADMGVMALTYDPTTALQNGFYPAPYNIT
PNRMLAQSALSPYLSSPVSSYQRVTQTSPLQVPNPSWMHHHSYLMQPSIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEE

--------------------------------------------------------------

>73026_73026_11_RBMS2-NACA_RBMS2_chr12_56980710_ENST00000542360_NACA_chr12_57106974_ENST00000546392_length(amino acids)=316AA_BP=57
MATIETTRRYGKIVSTKAILDKTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKAGVQWRDLDSLQPLPPRFKRFSHLCLLSSWD
YRMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNADMGVMALTYDPTTALQNGFYPAPYNIT
PNRMLAQSALSPYLSSPVSSYQRVTQTSPLQVPNPSWMHHHSYLMQPSIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEE

--------------------------------------------------------------

>73026_73026_12_RBMS2-NACA_RBMS2_chr12_56980710_ENST00000542360_NACA_chr12_57106974_ENST00000548563_length(amino acids)=316AA_BP=57
MATIETTRRYGKIVSTKAILDKTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKAGVQWRDLDSLQPLPPRFKRFSHLCLLSSWD
YRMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNADMGVMALTYDPTTALQNGFYPAPYNIT
PNRMLAQSALSPYLSSPVSSYQRVTQTSPLQVPNPSWMHHHSYLMQPSIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEE

--------------------------------------------------------------

>73026_73026_13_RBMS2-NACA_RBMS2_chr12_56980710_ENST00000542360_NACA_chr12_57106974_ENST00000550952_length(amino acids)=316AA_BP=57
MATIETTRRYGKIVSTKAILDKTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKAGVQWRDLDSLQPLPPRFKRFSHLCLLSSWD
YRMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNADMGVMALTYDPTTALQNGFYPAPYNIT
PNRMLAQSALSPYLSSPVSSYQRVTQTSPLQVPNPSWMHHHSYLMQPSIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEE

--------------------------------------------------------------

>73026_73026_14_RBMS2-NACA_RBMS2_chr12_56980710_ENST00000542360_NACA_chr12_57106974_ENST00000552540_length(amino acids)=316AA_BP=57
MATIETTRRYGKIVSTKAILDKTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKAGVQWRDLDSLQPLPPRFKRFSHLCLLSSWD
YRMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNADMGVMALTYDPTTALQNGFYPAPYNIT
PNRMLAQSALSPYLSSPVSSYQRVTQTSPLQVPNPSWMHHHSYLMQPSIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEE

--------------------------------------------------------------

>73026_73026_15_RBMS2-NACA_RBMS2_chr12_56980710_ENST00000550726_NACA_chr12_57106974_ENST00000356769_length(amino acids)=336AA_BP=248
MATIETTRRYGKIVSTKAILDKTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFG
QVISTRILRDTSGTSRGVGFARMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNADMGVMAL
TYDPTTALQNGFYPAPYNITPNRMLAQSALSPYLSSPVSSYQRVTQTSPLQVPNPSWMHHHSYLMQPSIEDLSQQAQLAAAEKFKVQGEA

--------------------------------------------------------------

>73026_73026_16_RBMS2-NACA_RBMS2_chr12_56980710_ENST00000550726_NACA_chr12_57106974_ENST00000393891_length(amino acids)=336AA_BP=248
MATIETTRRYGKIVSTKAILDKTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFG
QVISTRILRDTSGTSRGVGFARMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNADMGVMAL
TYDPTTALQNGFYPAPYNITPNRMLAQSALSPYLSSPVSSYQRVTQTSPLQVPNPSWMHHHSYLMQPSIEDLSQQAQLAAAEKFKVQGEA

--------------------------------------------------------------

>73026_73026_17_RBMS2-NACA_RBMS2_chr12_56980710_ENST00000550726_NACA_chr12_57106974_ENST00000454682_length(amino acids)=336AA_BP=248
MATIETTRRYGKIVSTKAILDKTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFG
QVISTRILRDTSGTSRGVGFARMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNADMGVMAL
TYDPTTALQNGFYPAPYNITPNRMLAQSALSPYLSSPVSSYQRVTQTSPLQVPNPSWMHHHSYLMQPSIEDLSQQAQLAAAEKFKVQGEA

--------------------------------------------------------------

>73026_73026_18_RBMS2-NACA_RBMS2_chr12_56980710_ENST00000550726_NACA_chr12_57106974_ENST00000546392_length(amino acids)=336AA_BP=248
MATIETTRRYGKIVSTKAILDKTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFG
QVISTRILRDTSGTSRGVGFARMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNADMGVMAL
TYDPTTALQNGFYPAPYNITPNRMLAQSALSPYLSSPVSSYQRVTQTSPLQVPNPSWMHHHSYLMQPSIEDLSQQAQLAAAEKFKVQGEA

--------------------------------------------------------------

>73026_73026_19_RBMS2-NACA_RBMS2_chr12_56980710_ENST00000550726_NACA_chr12_57106974_ENST00000548563_length(amino acids)=336AA_BP=248
MATIETTRRYGKIVSTKAILDKTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFG
QVISTRILRDTSGTSRGVGFARMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNADMGVMAL
TYDPTTALQNGFYPAPYNITPNRMLAQSALSPYLSSPVSSYQRVTQTSPLQVPNPSWMHHHSYLMQPSIEDLSQQAQLAAAEKFKVQGEA

--------------------------------------------------------------

>73026_73026_20_RBMS2-NACA_RBMS2_chr12_56980710_ENST00000550726_NACA_chr12_57106974_ENST00000550952_length(amino acids)=336AA_BP=248
MATIETTRRYGKIVSTKAILDKTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFG
QVISTRILRDTSGTSRGVGFARMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNADMGVMAL
TYDPTTALQNGFYPAPYNITPNRMLAQSALSPYLSSPVSSYQRVTQTSPLQVPNPSWMHHHSYLMQPSIEDLSQQAQLAAAEKFKVQGEA

--------------------------------------------------------------

>73026_73026_21_RBMS2-NACA_RBMS2_chr12_56980710_ENST00000550726_NACA_chr12_57106974_ENST00000552540_length(amino acids)=336AA_BP=248
MATIETTRRYGKIVSTKAILDKTTNKCKGYGFVDFDSPSAAQKAVTALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELEGMLKPFG
QVISTRILRDTSGTSRGVGFARMESTEKCEAIITHFNGKYIKTPPGVPAPSDPLLCKFADGGPKKRQNQGKFVQNGRAWPRNADMGVMAL
TYDPTTALQNGFYPAPYNITPNRMLAQSALSPYLSSPVSSYQRVTQTSPLQVPNPSWMHHHSYLMQPSIEDLSQQAQLAAAEKFKVQGEA

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:56980710/chr12:57106974)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NACA Q9H009
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RBMS2

chr12:56980710

chr12:57106974

ENST00000262031

135_220

317.0

961.6666666666666

Domain

RRM 2

Hgene

RBMS2

chr12:56980710

chr12:57106974

ENST00000262031

56_129

317.0

961.6666666666666

Domain

RRM 1

Tgene

NACA

chr12:56980710

chr12:57106974

ENST00000356769

176_213

127.0

216.0

Domain

Note=UBA

Tgene

NACA

chr12:56980710

chr12:57106974

ENST00000393891

176_213

127.0

216.0

Domain

Note=UBA

Tgene

NACA

chr12:56980710

chr12:57106974

ENST00000546392

176_213

127.0

216.0

Domain

Note=UBA

Tgene

NACA

chr12:56980710

chr12:57106974

ENST00000552540

176_213

127.0

216.0

Domain

Note=UBA

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NACA

chr12:56980710

chr12:57106974

ENST00000356769

70_135

127.0

216.0

Domain

NAC-A/B

Tgene

NACA

chr12:56980710

chr12:57106974

ENST00000393891

70_135

127.0

216.0

Domain

NAC-A/B

Tgene

NACA

chr12:56980710

chr12:57106974

ENST00000546392

70_135

127.0

216.0

Domain

NAC-A/B

Tgene

NACA

chr12:56980710

chr12:57106974

ENST00000552540

70_135

127.0

216.0

Domain

NAC-A/B

Tgene

NACA

chr12:56980710

chr12:57106974

ENST00000356769

69_80

127.0

216.0

Region

Required for DNA-binding

Tgene

NACA

chr12:56980710

chr12:57106974

ENST00000356769

93_108

127.0

216.0

Region

Note=RNA/DNA-binding

Tgene

NACA

chr12:56980710

chr12:57106974

ENST00000393891

69_80

127.0

216.0

Region

Required for DNA-binding

Tgene

NACA

chr12:56980710

chr12:57106974

ENST00000393891

93_108

127.0

216.0

Region

Note=RNA/DNA-binding

Tgene

NACA

chr12:56980710

chr12:57106974

ENST00000546392

69_80

127.0

216.0

Region

Required for DNA-binding

Tgene

NACA

chr12:56980710

chr12:57106974

ENST00000546392

93_108

127.0

216.0

Region

Note=RNA/DNA-binding

Tgene

NACA

chr12:56980710

chr12:57106974

ENST00000552540

69_80

127.0

216.0

Region

Required for DNA-binding

Tgene

NACA

chr12:56980710

chr12:57106974

ENST00000552540

93_108

127.0

216.0

Region

Note=RNA/DNA-binding

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
RBMS2
NACA

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to RBMS2-NACA

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to RBMS2-NACA

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source