UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:ASXL2-DTNB

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ASXL2-DTNB
FusionPDB ID: 7305
FusionGDB2.0 ID: 7305
HgeneTgene
Gene symbol

ASXL2

DTNB

Gene ID

55252

1838

Gene nameASXL transcriptional regulator 2dystrobrevin beta
SynonymsASXH2|SHAPNS-
Cytomap

2p23.3

2p23.3

Type of geneprotein-codingprotein-coding
Descriptionputative Polycomb group protein ASXL2additional sex combs like 2, transcriptional regulatoradditional sex combs-like protein 2polycomb group protein ASXH2dystrobrevin betaDTN-Bbeta-dystrobrevin
Modification date2020031320200327
UniProtAcc

Q76L83

Q96EV8

Ensembl transtripts involved in fusion geneENST idsENST00000336112, ENST00000435504, 
ENST00000272341, ENST00000497092, 
ENST00000404843, 		ENST00000472690, 
ENST00000545439, ENST00000288642, 
ENST00000404103, ENST00000405222, 
ENST00000406818, ENST00000407038, 
ENST00000407186, ENST00000407661, 
ENST00000496972, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 11 X 10=198014 X 13 X 9=1638
# samples 2415
** MAII scorelog2(24/1980*10)=-3.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1638*10)=-3.44890095114513
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ASXL2 [Title/Abstract] AND DTNB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DTNB(25818955)-ASXL2(25991737), # samples:3
ASXL2(26022254)-DTNB(25819109), # samples:1
Anticipated loss of major functional domain due to fusion event.ASXL2-DTNB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASXL2-DTNB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASXL2-DTNB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ASXL2-DTNB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DTNB-ASXL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DTNB-ASXL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ASXL2-DTNB seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ASXL2-DTNB seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ASXL2-DTNB seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ASXL2-DTNB seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
DTNB-ASXL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DTNB-ASXL2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
DTNB-ASXL2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
DTNB-ASXL2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneASXL2

GO:0035360

positive regulation of peroxisome proliferator activated receptor signaling pathway

21047783

HgeneASXL2

GO:0045600

positive regulation of fat cell differentiation

21047783

HgeneASXL2

GO:0045944

positive regulation of transcription by RNA polymerase II

21047783


check buttonFusion gene breakpoints across ASXL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DTNB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-QK-A8Z9ASXL2chr2

26022254

-DTNBchr2

25819109

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000435504ASXL2chr226022254-ENST00000496972DTNBchr225819109-24436971532057634
ENST00000435504ASXL2chr226022254-ENST00000405222DTNBchr225819109-22726971531931592
ENST00000435504ASXL2chr226022254-ENST00000407661DTNBchr225819109-24196971532078641
ENST00000435504ASXL2chr226022254-ENST00000406818DTNBchr225819109-24736971532132659
ENST00000435504ASXL2chr226022254-ENST00000407038DTNBchr225819109-22936971531952599
ENST00000435504ASXL2chr226022254-ENST00000404103DTNBchr225819109-23836971532042629
ENST00000435504ASXL2chr226022254-ENST00000407186DTNBchr225819109-23476971532021622
ENST00000435504ASXL2chr226022254-ENST00000288642DTNBchr225819109-23646971532042629

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000435504ENST00000496972ASXL2chr226022254-DTNBchr225819109-0.044473520.9555265
ENST00000435504ENST00000405222ASXL2chr226022254-DTNBchr225819109-0.0431925770.95680743
ENST00000435504ENST00000407661ASXL2chr226022254-DTNBchr225819109-0.0416368770.9583631
ENST00000435504ENST00000406818ASXL2chr226022254-DTNBchr225819109-0.037415240.9625848
ENST00000435504ENST00000407038ASXL2chr226022254-DTNBchr225819109-0.0402284530.9597716
ENST00000435504ENST00000404103ASXL2chr226022254-DTNBchr225819109-0.0375687780.9624312
ENST00000435504ENST00000407186ASXL2chr226022254-DTNBchr225819109-0.0402270670.9597729
ENST00000435504ENST00000288642ASXL2chr226022254-DTNBchr225819109-0.0352789760.964721

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>7305_7305_1_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000288642_length(amino acids)=629AA_BP=1
MLGCPPGLTSLFSHLSRHRGKSSAGQSRQGGRPEPGHGSLPVSSRPDMREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGL
KEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKR
KDVFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFEGPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADPPPQCLVWLPLMHRLAHVENVF
HPVECSYCRCESMMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPL
DLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGN
VTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMV

--------------------------------------------------------------

>7305_7305_2_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000404103_length(amino acids)=629AA_BP=1
MLGCPPGLTSLFSHLSRHRGKSSAGQSRQGGRPEPGHGSLPVSSRPDMREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGL
KEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKR
KDVFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFEGPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADPPPQCLVWLPLMHRLAHVENVF
HPVECSYCRCESMMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPL
DLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGN
VTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMV

--------------------------------------------------------------

>7305_7305_3_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000405222_length(amino acids)=592AA_BP=1
MLGCPPGLTSLFSHLSRHRGKSSAGQSRQGGRPEPGHGSLPVSSRPDMREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGL
KEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKR
KDVFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFEGPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADPPPQCLVWLPLMHRLAHVENVF
HPVECSYCRCESMMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPL
DLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKSVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNR
EILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKAQATGSPHTSPTHGGGRPMP

--------------------------------------------------------------

>7305_7305_4_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000406818_length(amino acids)=659AA_BP=1
MLGCPPGLTSLFSHLSRHRGKSSAGQSRQGGRPEPGHGSLPVSSRPDMREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGL
KEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKR
KDVFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFEGPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADPPPQCLVWLPLMHRLAHVENVF
HPVECSYCRCESMMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPL
DLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGN
VTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMV
QLEELMKLLKEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHCPQDSLSGVGGDVQEAFAQGTRRNLRNDLLVAADSITNT

--------------------------------------------------------------

>7305_7305_5_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000407038_length(amino acids)=599AA_BP=1
MLGCPPGLTSLFSHLSRHRGKSSAGQSRQGGRPEPGHGSLPVSSRPDMREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGL
KEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKR
KDVFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFEGPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADPPPQCLVWLPLMHRLAHVENVF
HPVECSYCRCESMMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPL
DLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKSVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNR
EILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEEEQKQAAQATGSPHTSPTH

--------------------------------------------------------------

>7305_7305_6_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000407186_length(amino acids)=622AA_BP=1
MLGCPPGLTSLFSHLSRHRGKSSAGQSRQGGRPEPGHGSLPVSSRPDMREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGL
KEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKR
KDVFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFEGPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADPPPQCLVWLPLMHRLAHVENVF
HPVECSYCRCESMMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPL
DLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKSVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNR
EILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKAQATGSPHTSPTHGGGRPMP

--------------------------------------------------------------

>7305_7305_7_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000407661_length(amino acids)=641AA_BP=1
MLGCPPGLTSLFSHLSRHRGKSSAGQSRQGGRPEPGHGSLPVSSRPDMREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGL
KEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKR
KDVFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFEGPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADPPPQCLVWLPLMHRLAHVENVF
HPVECSYCRCESMMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPL
DLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGN
VTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMV
QLEELMKLLKEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHCPQDSLSGVGGDVQEAFAQGTRRNLRNDLLVAADSITNT

--------------------------------------------------------------

>7305_7305_8_ASXL2-DTNB_ASXL2_chr2_26022254_ENST00000435504_DTNB_chr2_25819109_ENST00000496972_length(amino acids)=634AA_BP=1
MLGCPPGLTSLFSHLSRHRGKSSAGQSRQGGRPEPGHGSLPVSSRPDMREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGL
KEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKR
KDVFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFEGPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADPPPQCLVWLPLMHRLAHVENVF
HPVECSYCRCESMMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPL
DLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGN
VTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMV
QLEELMKLLKAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHCPQDSLSGVGGDVQEAFAQGTRRNLRNDLLVAADSITNTMSSLVKE

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:25818955/chr2:25991737)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASXL2

Q76L83

DTNB

Q96EV8

FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. {ECO:0000250, ECO:0000269|PubMed:21047783}.FUNCTION: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway. {ECO:0000269|PubMed:15345706, ECO:0000269|PubMed:16837549, ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:17989303, ECO:0000269|PubMed:19094965, ECO:0000269|PubMed:20180862, ECO:0000269|PubMed:20921223}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASXL2chr2:26022254chr2:25819109ENST00000435504-51311_86134.333333333333341436.0DomainHTH HARE-type
TgeneDTNBchr2:26022254chr2:25819109ENST00000404103420428_529149.33333333333334607.3333333333334Coiled coilOntology_term=ECO:0000255
TgeneDTNBchr2:26022254chr2:25819109ENST00000405222418428_529149.33333333333334570.3333333333334Coiled coilOntology_term=ECO:0000255
TgeneDTNBchr2:26022254chr2:25819109ENST00000406818421428_529149.33333333333334637.3333333333334Coiled coilOntology_term=ECO:0000255
TgeneDTNBchr2:26022254chr2:25819109ENST00000407038419428_529149.33333333333334577.3333333333334Coiled coilOntology_term=ECO:0000255
TgeneDTNBchr2:26022254chr2:25819109ENST00000407661420428_529149.33333333333334619.3333333333334Coiled coilOntology_term=ECO:0000255
TgeneDTNBchr2:26022254chr2:25819109ENST00000496972318428_52992.33333333333333581.3333333333334Coiled coilOntology_term=ECO:0000255
TgeneDTNBchr2:26022254chr2:25819109ENST00000404103420399_448149.33333333333334607.3333333333334RegionNote=Syntrophin-binding region
TgeneDTNBchr2:26022254chr2:25819109ENST00000405222418399_448149.33333333333334570.3333333333334RegionNote=Syntrophin-binding region
TgeneDTNBchr2:26022254chr2:25819109ENST00000406818421399_448149.33333333333334637.3333333333334RegionNote=Syntrophin-binding region
TgeneDTNBchr2:26022254chr2:25819109ENST00000407038419399_448149.33333333333334577.3333333333334RegionNote=Syntrophin-binding region
TgeneDTNBchr2:26022254chr2:25819109ENST00000407661420399_448149.33333333333334619.3333333333334RegionNote=Syntrophin-binding region
TgeneDTNBchr2:26022254chr2:25819109ENST00000496972318399_44892.33333333333333581.3333333333334RegionNote=Syntrophin-binding region
TgeneDTNBchr2:26022254chr2:25819109ENST00000404103420237_284149.33333333333334607.3333333333334Zinc fingerZZ-type
TgeneDTNBchr2:26022254chr2:25819109ENST00000405222418237_284149.33333333333334570.3333333333334Zinc fingerZZ-type
TgeneDTNBchr2:26022254chr2:25819109ENST00000406818421237_284149.33333333333334637.3333333333334Zinc fingerZZ-type
TgeneDTNBchr2:26022254chr2:25819109ENST00000407038419237_284149.33333333333334577.3333333333334Zinc fingerZZ-type
TgeneDTNBchr2:26022254chr2:25819109ENST00000407661420237_284149.33333333333334619.3333333333334Zinc fingerZZ-type
TgeneDTNBchr2:26022254chr2:25819109ENST00000496972318237_28492.33333333333333581.3333333333334Zinc fingerZZ-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASXL2chr2:26022254chr2:25819109ENST00000272341-4131173_11760919.0Compositional biasNote=Poly-Ser
HgeneASXL2chr2:26022254chr2:25819109ENST00000272341-413303_3070919.0Compositional biasNote=Poly-Leu
HgeneASXL2chr2:26022254chr2:25819109ENST00000272341-413654_6840919.0Compositional biasNote=Ala-rich
HgeneASXL2chr2:26022254chr2:25819109ENST00000272341-413687_7390919.0Compositional biasNote=Gly-rich
HgeneASXL2chr2:26022254chr2:25819109ENST00000272341-41395_2350919.0Compositional biasNote=Ser-rich
HgeneASXL2chr2:26022254chr2:25819109ENST00000404843-1101173_11760919.0Compositional biasNote=Poly-Ser
HgeneASXL2chr2:26022254chr2:25819109ENST00000404843-110303_3070919.0Compositional biasNote=Poly-Leu
HgeneASXL2chr2:26022254chr2:25819109ENST00000404843-110654_6840919.0Compositional biasNote=Ala-rich
HgeneASXL2chr2:26022254chr2:25819109ENST00000404843-110687_7390919.0Compositional biasNote=Gly-rich
HgeneASXL2chr2:26022254chr2:25819109ENST00000404843-11095_2350919.0Compositional biasNote=Ser-rich
HgeneASXL2chr2:26022254chr2:25819109ENST00000435504-5131173_1176134.333333333333341436.0Compositional biasNote=Poly-Ser
HgeneASXL2chr2:26022254chr2:25819109ENST00000435504-513303_307134.333333333333341436.0Compositional biasNote=Poly-Leu
HgeneASXL2chr2:26022254chr2:25819109ENST00000435504-513654_684134.333333333333341436.0Compositional biasNote=Ala-rich
HgeneASXL2chr2:26022254chr2:25819109ENST00000435504-513687_739134.333333333333341436.0Compositional biasNote=Gly-rich
HgeneASXL2chr2:26022254chr2:25819109ENST00000435504-51395_235134.333333333333341436.0Compositional biasNote=Ser-rich
HgeneASXL2chr2:26022254chr2:25819109ENST00000272341-41311_860919.0DomainHTH HARE-type
HgeneASXL2chr2:26022254chr2:25819109ENST00000272341-413274_3830919.0DomainDEUBAD
HgeneASXL2chr2:26022254chr2:25819109ENST00000404843-11011_860919.0DomainHTH HARE-type
HgeneASXL2chr2:26022254chr2:25819109ENST00000404843-110274_3830919.0DomainDEUBAD
HgeneASXL2chr2:26022254chr2:25819109ENST00000435504-513274_383134.333333333333341436.0DomainDEUBAD
HgeneASXL2chr2:26022254chr2:25819109ENST00000272341-413174_1780919.0MotifNuclear localization signal
HgeneASXL2chr2:26022254chr2:25819109ENST00000272341-413887_8910919.0MotifNote=LXXLL motif 2
HgeneASXL2chr2:26022254chr2:25819109ENST00000404843-110174_1780919.0MotifNuclear localization signal
HgeneASXL2chr2:26022254chr2:25819109ENST00000404843-110887_8910919.0MotifNote=LXXLL motif 2
HgeneASXL2chr2:26022254chr2:25819109ENST00000435504-513174_178134.333333333333341436.0MotifNuclear localization signal
HgeneASXL2chr2:26022254chr2:25819109ENST00000435504-513887_891134.333333333333341436.0MotifNote=LXXLL motif 2
HgeneASXL2chr2:26022254chr2:25819109ENST00000272341-4131397_14340919.0Zinc fingerNote=PHD-type%3B atypical
HgeneASXL2chr2:26022254chr2:25819109ENST00000404843-1101397_14340919.0Zinc fingerNote=PHD-type%3B atypical
HgeneASXL2chr2:26022254chr2:25819109ENST00000435504-5131397_1434134.333333333333341436.0Zinc fingerNote=PHD-type%3B atypical


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ASXL2all structure
DTNB


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to ASXL2-DTNB


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to ASXL2-DTNB


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneASXL2C0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneASXL2C0005695Bladder Neoplasm1CTD_human
HgeneASXL2C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneASXL2C0026998Acute Myeloid Leukemia, M11CTD_human
HgeneASXL2C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
HgeneASXL2C4310672SHASHI-PENA SYNDROME1GENOMICS_ENGLAND