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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ATAD1-KCNMA1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ATAD1-KCNMA1
FusionPDB ID: 7329
FusionGDB2.0 ID: 7329
HgeneTgene
Gene symbol

ATAD1

KCNMA1

Gene ID

84896

3778

Gene nameATPase family AAA domain containing 1potassium calcium-activated channel subfamily M alpha 1
SynonymsAFDC1|FNP001|HKPX4|Msp1|THORASEBKTM|CADEDS|IEG16|KCa1.1|LIWAS|MaxiK|PNKD3|SAKCA|SLO|SLO-ALPHA|SLO1|bA205K10.1|hSlo|mSLO1
Cytomap

10q23.31

10q22.3

Type of geneprotein-codingprotein-coding
DescriptionATPase family AAA domain-containing protein 1calcium-activated potassium channel subunit alpha-1uncharacterized proteinBK channel alpha subunitBKCA alpha subunitbig potassium channel alpha subunitcalcium-activated potassium channel, subfamily M subunit alpha-1k(VCA)alphamaxi-K channel HSLOpo
Modification date2020031320200315
UniProtAcc

Q8NBU5

Q12791

Ensembl transtripts involved in fusion geneENST idsENST00000308448, ENST00000328142, 
ENST00000541004, ENST00000495903, 
ENST00000400215, 		ENST00000480683, 
ENST00000481070, ENST00000484507, 
ENST00000286627, ENST00000286628, 
ENST00000354353, ENST00000372440, 
ENST00000372443, ENST00000404771, 
ENST00000404857, ENST00000406533, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 8 X 7=61618 X 17 X 8=2448
# samples 1221
** MAII scorelog2(12/616*10)=-2.35989594508638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/2448*10)=-3.54314232502653
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ATAD1 [Title/Abstract] AND KCNMA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ATAD1(89574195)-KCNMA1(79011014), # samples:2
Anticipated loss of major functional domain due to fusion event.ATAD1-KCNMA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATAD1-KCNMA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATAD1-KCNMA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATAD1-KCNMA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATAD1-KCNMA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ATAD1-KCNMA1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKCNMA1

GO:0001666

response to hypoxia

15528406

TgeneKCNMA1

GO:0006813

potassium ion transport

7573516|7877450|11245614|12388065|17706472|18458941

TgeneKCNMA1

GO:0006970

response to osmotic stress

10840032|12388065

TgeneKCNMA1

GO:0030007

cellular potassium ion homeostasis

11245614

TgeneKCNMA1

GO:0034465

response to carbon monoxide

15528406

TgeneKCNMA1

GO:0042391

regulation of membrane potential

7877450|7993625

TgeneKCNMA1

GO:0045794

negative regulation of cell volume

12388065

TgeneKCNMA1

GO:0051592

response to calcium ion

12388065|18458941

TgeneKCNMA1

GO:0060073

micturition

11641143

TgeneKCNMA1

GO:0060083

smooth muscle contraction involved in micturition

11641143


check buttonFusion gene breakpoints across ATAD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KCNMA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0645-01AATAD1chr10

89574195

-KCNMA1chr10

79011014

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000328142ATAD1chr1089574195-ENST00000404771KCNMA1chr1079011014-391444525337711172
ENST00000328142ATAD1chr1089574195-ENST00000372440KCNMA1chr1079011014-371144525334381061
ENST00000328142ATAD1chr1089574195-ENST00000372443KCNMA1chr1079011014-379544525335221089
ENST00000328142ATAD1chr1089574195-ENST00000286628KCNMA1chr1079011014-600144525336151120
ENST00000328142ATAD1chr1089574195-ENST00000286627KCNMA1chr1079011014-582744525334411062
ENST00000328142ATAD1chr1089574195-ENST00000354353KCNMA1chr1079011014-362544525336241124
ENST00000328142ATAD1chr1089574195-ENST00000404857KCNMA1chr1079011014-356544525335641104
ENST00000328142ATAD1chr1089574195-ENST00000406533KCNMA1chr1079011014-362844525336271125

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000328142ENST00000404771ATAD1chr1089574195-KCNMA1chr1079011014-0.0005632450.9994367
ENST00000328142ENST00000372440ATAD1chr1089574195-KCNMA1chr1079011014-0.0006437420.9993562
ENST00000328142ENST00000372443ATAD1chr1089574195-KCNMA1chr1079011014-0.0004105910.9995894
ENST00000328142ENST00000286628ATAD1chr1089574195-KCNMA1chr1079011014-0.0004299910.99956995
ENST00000328142ENST00000286627ATAD1chr1089574195-KCNMA1chr1079011014-0.0002833970.9997166
ENST00000328142ENST00000354353ATAD1chr1089574195-KCNMA1chr1079011014-0.000709980.99929
ENST00000328142ENST00000404857ATAD1chr1089574195-KCNMA1chr1079011014-0.0004140630.9995859
ENST00000328142ENST00000406533ATAD1chr1089574195-KCNMA1chr1079011014-0.0004547080.9995453

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>7329_7329_1_ATAD1-KCNMA1_ATAD1_chr10_89574195_ENST00000328142_KCNMA1_chr10_79011014_ENST00000286627_length(amino acids)=1062AA_BP=63
MFVFLRLTFKMVHAEAFSRPLSRNEVVGLIFRLTIFGAVTYFTIKWMVDAIDPTRKQKVEAQKQVVLVFALSIGALVIYFIDSSNPIESC
QNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSN
SIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPE
IIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDL
ARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQ
GLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQE
GTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRLEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDS
NVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLH
NFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPV
HGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEA
LIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEF

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>7329_7329_2_ATAD1-KCNMA1_ATAD1_chr10_89574195_ENST00000328142_KCNMA1_chr10_79011014_ENST00000286628_length(amino acids)=1120AA_BP=63
MFVFLRLTFKMVHAEAFSRPLSRNEVVGLIFRLTIFGAVTYFTIKWMVDAIDPTRKQKVEAQKQVVLVFALSIGALVIYFIDSSNPIESC
QNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSN
SIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPE
IIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDL
ARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQ
GLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQE
GTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRPKMSIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERAFPLSSVSV
NDCSTSFRAFEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMT
VLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVIL
SANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQ
DDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALL
DGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSS

--------------------------------------------------------------

>7329_7329_3_ATAD1-KCNMA1_ATAD1_chr10_89574195_ENST00000328142_KCNMA1_chr10_79011014_ENST00000354353_length(amino acids)=1124AA_BP=63
MFVFLRLTFKMVHAEAFSRPLSRNEVVGLIFRLTIFGAVTYFTIKWMVDAIDPTRKQKVEAQKQVVLVFALSIGALVIYFIDSSNPIESC
QNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSN
SIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPE
IIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDL
ARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQ
GLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQE
GTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRRWEEHCSLWRLESKGNVRRLNYCRGQQTFSVKVKVAARSRYSKDPFEFK
KETPNSRLVTEPVEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEA
AMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMC
VILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQF
LDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQL
ALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSS

--------------------------------------------------------------

>7329_7329_4_ATAD1-KCNMA1_ATAD1_chr10_89574195_ENST00000328142_KCNMA1_chr10_79011014_ENST00000372440_length(amino acids)=1061AA_BP=63
MFVFLRLTFKMVHAEAFSRPLSRNEVVGLIFRLTIFGAVTYFTIKWMVDAIDPTRKQKVEAQKQVVLVFALSIGALVIYFIDSSNPIESC
QNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSN
SIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPE
IIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDL
ARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQ
GLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQE
GTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRLEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDS
NVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLH
NFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPV
HGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEA
LIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEF

--------------------------------------------------------------

>7329_7329_5_ATAD1-KCNMA1_ATAD1_chr10_89574195_ENST00000328142_KCNMA1_chr10_79011014_ENST00000372443_length(amino acids)=1089AA_BP=63
MFVFLRLTFKMVHAEAFSRPLSRNEVVGLIFRLTIFGAVTYFTIKWMVDAIDPTRKQKVEAQKQVVLVFALSIGALVIYFIDSSNPIESC
QNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSN
SIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPE
IIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDL
ARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQ
GLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQE
GTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRLEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDS
NVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLH
NFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPV
HGMLRQPSITTGVNIPIITELAKPGKLPLVSVNQEKNSGTHILMITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLM
SATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGI
YRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRQNRPKSRESRDK

--------------------------------------------------------------

>7329_7329_6_ATAD1-KCNMA1_ATAD1_chr10_89574195_ENST00000328142_KCNMA1_chr10_79011014_ENST00000404771_length(amino acids)=1172AA_BP=63
MFVFLRLTFKMVHAEAFSRPLSRNEVVGLIFRLTIFGAVTYFTIKWMVDAIDPTRKQKVEAQKQVVLVFALSIGALVIYFIDSSNPIESC
QNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSN
SIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPE
IIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDL
ARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQ
GLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQE
GTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRPKMSIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERAFPLSSVSV
NDCSTSFRAFEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMT
VLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVIL
SANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQ
DDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALL
DGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSS
QSSSKKSSSVHSIPSTANRQNRPKSRESRDKQNATRMNRMGQEKKWFTDEPDNAYPRNIQIKPMSTHMANQINQYKSTSSLIPPIREVED

--------------------------------------------------------------

>7329_7329_7_ATAD1-KCNMA1_ATAD1_chr10_89574195_ENST00000328142_KCNMA1_chr10_79011014_ENST00000404857_length(amino acids)=1104AA_BP=63
MFVFLRLTFKMVHAEAFSRPLSRNEVVGLIFRLTIFGAVTYFTIKWMVDAIDPTRKQKVEAQKQVVLVFALSIGALVIYFIDSSNPIESC
QNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSN
SIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPE
IIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDL
ARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQ
GLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQE
GTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRLEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDS
NVKKYDSTGMFHWCAPKEIEKVILVTGWMPYLGPRVLMTCLDIGVVCMPTDIQSTSPASIKKFKETRSEAAMTVLSGHVVVCIFGDVSSA
LIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKEC
ILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFA
CGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLF
CKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTA

--------------------------------------------------------------

>7329_7329_8_ATAD1-KCNMA1_ATAD1_chr10_89574195_ENST00000328142_KCNMA1_chr10_79011014_ENST00000406533_length(amino acids)=1125AA_BP=63
MFVFLRLTFKMVHAEAFSRPLSRNEVVGLIFRLTIFGAVTYFTIKWMVDAIDPTRKQKVEAQKQVVLVFALSIGALVIYFIDSSNPIESC
QNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSN
SIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPE
IIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDL
ARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQ
GLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRGRLSILINPGNHL
KIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRPKMSIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERAFPLS
SVSVNDCSTSFRAFEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSE
AAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDM
CVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQ
FLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQ
LALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHS

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:89574195/chr10:79011014)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATAD1

Q8NBU5

KCNMA1

Q12791

FUNCTION: Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (PubMed:24843043). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (By similarity). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity). {ECO:0000250|UniProtKB:P28737, ECO:0000250|UniProtKB:Q9D5T0, ECO:0000269|PubMed:24843043}.FUNCTION: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+) (PubMed:29330545, PubMed:31152168). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). {ECO:0000269|PubMed:29330545, ECO:0000269|PubMed:31152168}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATAD1chr10:89574195chr10:79011014ENST00000308448-2101_1554.0362.0Topological domainMitochondrial intermembrane
HgeneATAD1chr10:89574195chr10:79011014ENST00000328142-191_1554.0362.0Topological domainMitochondrial intermembrane
HgeneATAD1chr10:89574195chr10:79011014ENST00000541004-291_1554.0288.0Topological domainMitochondrial intermembrane
HgeneATAD1chr10:89574195chr10:79011014ENST00000308448-21016_3254.0362.0TransmembraneHelical
HgeneATAD1chr10:89574195chr10:79011014ENST00000328142-1916_3254.0362.0TransmembraneHelical
HgeneATAD1chr10:89574195chr10:79011014ENST00000541004-2916_3254.0288.0TransmembraneHelical
TgeneKCNMA1chr10:89574195chr10:79011014ENST000004806830213_200169.0Compositional biasNote=Poly-Gly
TgeneKCNMA1chr10:89574195chr10:79011014ENST000004806830239_600169.0Compositional biasNote=Poly-Ser
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000480683024_100169.0Compositional biasNote=Poly-Gly
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286627127415_558180.01179.0DomainNote=RCK N-terminal
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286628128415_558180.01237.0DomainNote=RCK N-terminal
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000404857128415_558180.01220.0DomainNote=RCK N-terminal
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000048068302415_5580169.0DomainNote=RCK N-terminal
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286627127336_358180.01179.0IntramembranePore-forming%3B Name%3DP region
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286628128336_358180.01237.0IntramembranePore-forming%3B Name%3DP region
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000404857128336_358180.01220.0IntramembranePore-forming%3B Name%3DP region
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000048068302336_3580169.0IntramembranePore-forming%3B Name%3DP region
TgeneKCNMA1chr10:89574195chr10:79011014ENST000002866271271003_1025180.01179.0MotifNote=Calcium bowl
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286627127352_355180.01179.0MotifNote=Selectivity for potassium
TgeneKCNMA1chr10:89574195chr10:79011014ENST000002866281281003_1025180.01237.0MotifNote=Calcium bowl
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286628128352_355180.01237.0MotifNote=Selectivity for potassium
TgeneKCNMA1chr10:89574195chr10:79011014ENST000004048571281003_1025180.01220.0MotifNote=Calcium bowl
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000404857128352_355180.01220.0MotifNote=Selectivity for potassium
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000480683021003_10250169.0MotifNote=Calcium bowl
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000048068302352_3550169.0MotifNote=Selectivity for potassium
TgeneKCNMA1chr10:89574195chr10:79011014ENST000002866271271032_1052180.01179.0RegionNote=Segment S10
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286627127556_576180.01179.0RegionNote=Segment S7
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286627127613_633180.01179.0RegionNote=Segment S8
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286627127677_681180.01179.0RegionNote=Heme-binding motif
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286627127837_857180.01179.0RegionNote=Segment S9
TgeneKCNMA1chr10:89574195chr10:79011014ENST000002866281281032_1052180.01237.0RegionNote=Segment S10
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286628128556_576180.01237.0RegionNote=Segment S7
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286628128613_633180.01237.0RegionNote=Segment S8
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286628128677_681180.01237.0RegionNote=Heme-binding motif
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286628128837_857180.01237.0RegionNote=Segment S9
TgeneKCNMA1chr10:89574195chr10:79011014ENST000004048571281032_1052180.01220.0RegionNote=Segment S10
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000404857128556_576180.01220.0RegionNote=Segment S7
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000404857128613_633180.01220.0RegionNote=Segment S8
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000404857128677_681180.01220.0RegionNote=Heme-binding motif
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000404857128837_857180.01220.0RegionNote=Segment S9
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000480683021032_10520169.0RegionNote=Segment S10
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000048068302556_5760169.0RegionNote=Segment S7
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000048068302613_6330169.0RegionNote=Segment S8
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000048068302677_6810169.0RegionNote=Heme-binding motif
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000048068302837_8570169.0RegionNote=Segment S9
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286627127200_214180.01179.0Topological domainExtracellular
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286627127236_239180.01179.0Topological domainCytoplasmic
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286627127261_264180.01179.0Topological domainExtracellular
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286627127286_300180.01179.0Topological domainCytoplasmic
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286627127322_335180.01179.0Topological domainExtracellular
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286627127359_367180.01179.0Topological domainExtracellular
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286627127389_1236180.01179.0Topological domainCytoplasmic
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286628128200_214180.01237.0Topological domainExtracellular
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286628128236_239180.01237.0Topological domainCytoplasmic
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286628128261_264180.01237.0Topological domainExtracellular
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286628128286_300180.01237.0Topological domainCytoplasmic
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286628128322_335180.01237.0Topological domainExtracellular
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286628128359_367180.01237.0Topological domainExtracellular
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286628128389_1236180.01237.0Topological domainCytoplasmic
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000404857128200_214180.01220.0Topological domainExtracellular
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000404857128236_239180.01220.0Topological domainCytoplasmic
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000404857128261_264180.01220.0Topological domainExtracellular
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000404857128286_300180.01220.0Topological domainCytoplasmic
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000404857128322_335180.01220.0Topological domainExtracellular
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000404857128359_367180.01220.0Topological domainExtracellular
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000404857128389_1236180.01220.0Topological domainCytoplasmic
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000048068302108_1780169.0Topological domainCytoplasmic
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000480683021_860169.0Topological domainExtracellular
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000048068302200_2140169.0Topological domainExtracellular
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000048068302236_2390169.0Topological domainCytoplasmic
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000048068302261_2640169.0Topological domainExtracellular
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000048068302286_3000169.0Topological domainCytoplasmic
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000048068302322_3350169.0Topological domainExtracellular
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000048068302359_3670169.0Topological domainExtracellular
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000048068302389_12360169.0Topological domainCytoplasmic
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286627127179_199180.01179.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286627127215_235180.01179.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286627127240_260180.01179.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286627127265_285180.01179.0TransmembraneHelical%3B Name%3DSegment S4
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286627127301_321180.01179.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286627127368_388180.01179.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286628128179_199180.01237.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286628128215_235180.01237.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286628128240_260180.01237.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286628128265_285180.01237.0TransmembraneHelical%3B Name%3DSegment S4
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286628128301_321180.01237.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286628128368_388180.01237.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000404857128179_199180.01220.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000404857128215_235180.01220.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000404857128240_260180.01220.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000404857128265_285180.01220.0TransmembraneHelical%3B Name%3DSegment S4
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000404857128301_321180.01220.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000404857128368_388180.01220.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000048068302179_1990169.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000048068302215_2350169.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000048068302240_2600169.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000048068302265_2850169.0TransmembraneHelical%3B Name%3DSegment S4
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000048068302301_3210169.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000048068302368_3880169.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNMA1chr10:89574195chr10:79011014ENST000004806830287_1070169.0TransmembraneHelical%3B Name%3DSegment S0

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATAD1chr10:89574195chr10:79011014ENST00000308448-210133_14054.0362.0Nucleotide bindingATP
HgeneATAD1chr10:89574195chr10:79011014ENST00000328142-19133_14054.0362.0Nucleotide bindingATP
HgeneATAD1chr10:89574195chr10:79011014ENST00000541004-29133_14054.0288.0Nucleotide bindingATP
HgeneATAD1chr10:89574195chr10:79011014ENST00000308448-21033_36154.0362.0Topological domainCytoplasmic
HgeneATAD1chr10:89574195chr10:79011014ENST00000328142-1933_36154.0362.0Topological domainCytoplasmic
HgeneATAD1chr10:89574195chr10:79011014ENST00000541004-2933_36154.0288.0Topological domainCytoplasmic
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000028662712713_20180.01179.0Compositional biasNote=Poly-Gly
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000028662712739_60180.01179.0Compositional biasNote=Poly-Ser
TgeneKCNMA1chr10:89574195chr10:79011014ENST000002866271274_10180.01179.0Compositional biasNote=Poly-Gly
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000028662812813_20180.01237.0Compositional biasNote=Poly-Gly
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000028662812839_60180.01237.0Compositional biasNote=Poly-Ser
TgeneKCNMA1chr10:89574195chr10:79011014ENST000002866281284_10180.01237.0Compositional biasNote=Poly-Gly
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000040485712813_20180.01220.0Compositional biasNote=Poly-Gly
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000040485712839_60180.01220.0Compositional biasNote=Poly-Ser
TgeneKCNMA1chr10:89574195chr10:79011014ENST000004048571284_10180.01220.0Compositional biasNote=Poly-Gly
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286627127108_178180.01179.0Topological domainCytoplasmic
TgeneKCNMA1chr10:89574195chr10:79011014ENST000002866271271_86180.01179.0Topological domainExtracellular
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000286628128108_178180.01237.0Topological domainCytoplasmic
TgeneKCNMA1chr10:89574195chr10:79011014ENST000002866281281_86180.01237.0Topological domainExtracellular
TgeneKCNMA1chr10:89574195chr10:79011014ENST00000404857128108_178180.01220.0Topological domainCytoplasmic
TgeneKCNMA1chr10:89574195chr10:79011014ENST000004048571281_86180.01220.0Topological domainExtracellular
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000028662712787_107180.01179.0TransmembraneHelical%3B Name%3DSegment S0
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000028662812887_107180.01237.0TransmembraneHelical%3B Name%3DSegment S0
TgeneKCNMA1chr10:89574195chr10:79011014ENST0000040485712887_107180.01220.0TransmembraneHelical%3B Name%3DSegment S0


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ATAD1
KCNMA1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ATAD1-KCNMA1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ATAD1-KCNMA1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource