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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:RELB-ZNF227

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: RELB-ZNF227
	FusionPDB ID: 73432
	FusionGDB2.0 ID: 73432
		Hgene	Tgene
	Gene symbol	RELB	ZNF227
	Gene ID	5971	7770
	Gene name	RELB proto-oncogene, NF-kB subunit	zinc finger protein 227
	Synonyms	I-REL\|IMD53\|IREL\|REL-B	-
	Cytomap	19q13.32	19q13.31
	Type of gene	protein-coding	protein-coding
	Description	transcription factor RelBv-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gen	zinc finger protein 227
	Modification date	20200315	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000221452, ENST00000505236, ENST00000540120,	ENST00000589237, ENST00000313040, ENST00000586228, ENST00000589707, ENST00000391961, ENST00000589005,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 4 X 5=140	2 X 3 X 2=12
	# samples	8	3
	** MAII score	log2(8/140*10)=-0.807354922057604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: RELB [Title/Abstract] AND ZNF227 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	RELB(45532250)-ZNF227(44738855), # samples:2 RELB(45532250)-ZNF227(44738854), # samples:2
Anticipated loss of major functional domain due to fusion event.	RELB-ZNF227 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RELB-ZNF227 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RELB-ZNF227 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RELB-ZNF227 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RELB-ZNF227 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. RELB-ZNF227 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across RELB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ZNF227 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A8NI-01A	RELB	chr19	45532250	+	ZNF227	chr19	44738855	+
ChimerDB4	ESCA	TCGA-L5-A8NI	RELB	chr19	45532250	+	ZNF227	chr19	44738854	+
ChimerDB4	ESCA	TCGA-L5-A8NI	RELB	chr19	45532250	+	ZNF227	chr19	44738855	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000221452	RELB	chr19	45532250	+	ENST00000589005	ZNF227	chr19	44738855	+	3707	1141	150	3269	1039
ENST00000221452	RELB	chr19	45532250	+	ENST00000391961	ZNF227	chr19	44738855	+	3707	1141	150	3269	1039
ENST00000540120	RELB	chr19	45532250	+	ENST00000589005	ZNF227	chr19	44738855	+	3683	1117	126	3245	1039
ENST00000540120	RELB	chr19	45532250	+	ENST00000391961	ZNF227	chr19	44738855	+	3683	1117	126	3245	1039
ENST00000505236	RELB	chr19	45532250	+	ENST00000589005	ZNF227	chr19	44738855	+	3667	1101	119	3229	1036
ENST00000505236	RELB	chr19	45532250	+	ENST00000391961	ZNF227	chr19	44738855	+	3667	1101	119	3229	1036
ENST00000221452	RELB	chr19	45532250	+	ENST00000589005	ZNF227	chr19	44738854	+	3707	1141	150	3269	1039
ENST00000221452	RELB	chr19	45532250	+	ENST00000391961	ZNF227	chr19	44738854	+	3707	1141	150	3269	1039
ENST00000540120	RELB	chr19	45532250	+	ENST00000589005	ZNF227	chr19	44738854	+	3683	1117	126	3245	1039
ENST00000540120	RELB	chr19	45532250	+	ENST00000391961	ZNF227	chr19	44738854	+	3683	1117	126	3245	1039
ENST00000505236	RELB	chr19	45532250	+	ENST00000589005	ZNF227	chr19	44738854	+	3667	1101	119	3229	1036
ENST00000505236	RELB	chr19	45532250	+	ENST00000391961	ZNF227	chr19	44738854	+	3667	1101	119	3229	1036

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000221452	ENST00000589005	RELB	chr19	45532250	+	ZNF227	chr19	44738855	+	0.000510792	0.9994892
ENST00000221452	ENST00000391961	RELB	chr19	45532250	+	ZNF227	chr19	44738855	+	0.000510792	0.9994892
ENST00000540120	ENST00000589005	RELB	chr19	45532250	+	ZNF227	chr19	44738855	+	0.000502008	0.999498
ENST00000540120	ENST00000391961	RELB	chr19	45532250	+	ZNF227	chr19	44738855	+	0.000502008	0.999498
ENST00000505236	ENST00000589005	RELB	chr19	45532250	+	ZNF227	chr19	44738855	+	0.000376505	0.9996234
ENST00000505236	ENST00000391961	RELB	chr19	45532250	+	ZNF227	chr19	44738855	+	0.000376505	0.9996234
ENST00000221452	ENST00000589005	RELB	chr19	45532250	+	ZNF227	chr19	44738854	+	0.000510792	0.9994892
ENST00000221452	ENST00000391961	RELB	chr19	45532250	+	ZNF227	chr19	44738854	+	0.000510792	0.9994892
ENST00000540120	ENST00000589005	RELB	chr19	45532250	+	ZNF227	chr19	44738854	+	0.000502008	0.999498
ENST00000540120	ENST00000391961	RELB	chr19	45532250	+	ZNF227	chr19	44738854	+	0.000502008	0.999498
ENST00000505236	ENST00000589005	RELB	chr19	45532250	+	ZNF227	chr19	44738854	+	0.000376505	0.9996234
ENST00000505236	ENST00000391961	RELB	chr19	45532250	+	ZNF227	chr19	44738854	+	0.000376505	0.9996234

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>73432_73432_1_RELB-ZNF227_RELB_chr19_45532250_ENST00000221452_ZNF227_chr19_44738854_ENST00000391961_length(amino acids)=1039AA_BP=485
MLRSGPASGPSVPTGRAMPSRRVARPPAAPELGALGSPDLSSLSLAVSRSTDELEIIDEYIKENGFGLDGGQPGPGEGLPRLVSRGAASL
STVTLGPVAPPATPPPWGCPLGRLVSPAPGPGPQPHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEV
TACLVWKDWPHRVHPHSLVGKDCTDGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICF
QASYRDQQGQMRRMDPVLSEPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQKGSKHQNKMETLQKFALKYLSNQELSCWQIW
KQVASELTRCLQGKSSQLLQGDSIQVSENENNIMNPKGDSSIYIENQEFPFWRTQHSCGNTYLSESQIQSRGKQIDVKNNLQIHEDFMKK
SPFHEHIKTDTEPKPCKGNEYGKIISDGSNQKLPLGEKPHPCGECGRGFSYSPRLPLHPNVHTGEKCFSQSSHLRTHQRIHPGEKLNRCH
ESGDCFNKSSFHSYQSNHTGEKSYRCDSCGKGFSSSTGLIIHYRTHTGEKPYKCEECGKCFSQSSNFQCHQRVHTEEKPYKCEECGKGFG
WSVNLRVHQRVHRGEKPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDVCGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLH
IHFRVHTGEKPYKCKECGKGFSQASNLQVHQNVHTGEKRFKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKLHQVIH
TGEKPYKCEECGKGFSWRSNLHAHQRVHSGEKPYKCEQCDKSFSQAIDFRVHQRVHTGEKPYKCGVCGKGFSQSSGLQSHQRVHTGEKPY
KCDVCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKGFGRSLNLRHHQRVHTGEKPHICEECGKAFSLPSNLRVHLGVHTREKLFKCEECG

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>73432_73432_2_RELB-ZNF227_RELB_chr19_45532250_ENST00000221452_ZNF227_chr19_44738854_ENST00000589005_length(amino acids)=1039AA_BP=485
MLRSGPASGPSVPTGRAMPSRRVARPPAAPELGALGSPDLSSLSLAVSRSTDELEIIDEYIKENGFGLDGGQPGPGEGLPRLVSRGAASL
STVTLGPVAPPATPPPWGCPLGRLVSPAPGPGPQPHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEV
TACLVWKDWPHRVHPHSLVGKDCTDGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICF
QASYRDQQGQMRRMDPVLSEPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQKGSKHQNKMETLQKFALKYLSNQELSCWQIW
KQVASELTRCLQGKSSQLLQGDSIQVSENENNIMNPKGDSSIYIENQEFPFWRTQHSCGNTYLSESQIQSRGKQIDVKNNLQIHEDFMKK
SPFHEHIKTDTEPKPCKGNEYGKIISDGSNQKLPLGEKPHPCGECGRGFSYSPRLPLHPNVHTGEKCFSQSSHLRTHQRIHPGEKLNRCH
ESGDCFNKSSFHSYQSNHTGEKSYRCDSCGKGFSSSTGLIIHYRTHTGEKPYKCEECGKCFSQSSNFQCHQRVHTEEKPYKCEECGKGFG
WSVNLRVHQRVHRGEKPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDVCGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLH
IHFRVHTGEKPYKCKECGKGFSQASNLQVHQNVHTGEKRFKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKLHQVIH
TGEKPYKCEECGKGFSWRSNLHAHQRVHSGEKPYKCEQCDKSFSQAIDFRVHQRVHTGEKPYKCGVCGKGFSQSSGLQSHQRVHTGEKPY
KCDVCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKGFGRSLNLRHHQRVHTGEKPHICEECGKAFSLPSNLRVHLGVHTREKLFKCEECG

--------------------------------------------------------------

>73432_73432_3_RELB-ZNF227_RELB_chr19_45532250_ENST00000221452_ZNF227_chr19_44738855_ENST00000391961_length(amino acids)=1039AA_BP=485
MLRSGPASGPSVPTGRAMPSRRVARPPAAPELGALGSPDLSSLSLAVSRSTDELEIIDEYIKENGFGLDGGQPGPGEGLPRLVSRGAASL
STVTLGPVAPPATPPPWGCPLGRLVSPAPGPGPQPHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEV
TACLVWKDWPHRVHPHSLVGKDCTDGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICF
QASYRDQQGQMRRMDPVLSEPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQKGSKHQNKMETLQKFALKYLSNQELSCWQIW
KQVASELTRCLQGKSSQLLQGDSIQVSENENNIMNPKGDSSIYIENQEFPFWRTQHSCGNTYLSESQIQSRGKQIDVKNNLQIHEDFMKK
SPFHEHIKTDTEPKPCKGNEYGKIISDGSNQKLPLGEKPHPCGECGRGFSYSPRLPLHPNVHTGEKCFSQSSHLRTHQRIHPGEKLNRCH
ESGDCFNKSSFHSYQSNHTGEKSYRCDSCGKGFSSSTGLIIHYRTHTGEKPYKCEECGKCFSQSSNFQCHQRVHTEEKPYKCEECGKGFG
WSVNLRVHQRVHRGEKPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDVCGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLH
IHFRVHTGEKPYKCKECGKGFSQASNLQVHQNVHTGEKRFKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKLHQVIH
TGEKPYKCEECGKGFSWRSNLHAHQRVHSGEKPYKCEQCDKSFSQAIDFRVHQRVHTGEKPYKCGVCGKGFSQSSGLQSHQRVHTGEKPY
KCDVCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKGFGRSLNLRHHQRVHTGEKPHICEECGKAFSLPSNLRVHLGVHTREKLFKCEECG

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>73432_73432_4_RELB-ZNF227_RELB_chr19_45532250_ENST00000221452_ZNF227_chr19_44738855_ENST00000589005_length(amino acids)=1039AA_BP=485
MLRSGPASGPSVPTGRAMPSRRVARPPAAPELGALGSPDLSSLSLAVSRSTDELEIIDEYIKENGFGLDGGQPGPGEGLPRLVSRGAASL
STVTLGPVAPPATPPPWGCPLGRLVSPAPGPGPQPHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEV
TACLVWKDWPHRVHPHSLVGKDCTDGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICF
QASYRDQQGQMRRMDPVLSEPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQKGSKHQNKMETLQKFALKYLSNQELSCWQIW
KQVASELTRCLQGKSSQLLQGDSIQVSENENNIMNPKGDSSIYIENQEFPFWRTQHSCGNTYLSESQIQSRGKQIDVKNNLQIHEDFMKK
SPFHEHIKTDTEPKPCKGNEYGKIISDGSNQKLPLGEKPHPCGECGRGFSYSPRLPLHPNVHTGEKCFSQSSHLRTHQRIHPGEKLNRCH
ESGDCFNKSSFHSYQSNHTGEKSYRCDSCGKGFSSSTGLIIHYRTHTGEKPYKCEECGKCFSQSSNFQCHQRVHTEEKPYKCEECGKGFG
WSVNLRVHQRVHRGEKPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDVCGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLH
IHFRVHTGEKPYKCKECGKGFSQASNLQVHQNVHTGEKRFKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKLHQVIH
TGEKPYKCEECGKGFSWRSNLHAHQRVHSGEKPYKCEQCDKSFSQAIDFRVHQRVHTGEKPYKCGVCGKGFSQSSGLQSHQRVHTGEKPY
KCDVCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKGFGRSLNLRHHQRVHTGEKPHICEECGKAFSLPSNLRVHLGVHTREKLFKCEECG

--------------------------------------------------------------

>73432_73432_5_RELB-ZNF227_RELB_chr19_45532250_ENST00000505236_ZNF227_chr19_44738854_ENST00000391961_length(amino acids)=1036AA_BP=482
MLRSGPASGPSVPTGRAMPSRRVARPPAAPELGALGSPDLSSLSLAVSRSTEIIDEYIKENGFGLDGGQPGPGEGLPRLVSRGAASLSTV
TLGPVAPPATPPPWGCPLGRLVSPAPGPGPQPHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTAC
LVWKDWPHRVHPHSLVGKDCTDGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQAS
YRDQQGQMRRMDPVLSEPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQKGSKHQNKMETLQKFALKYLSNQELSCWQIWKQV
ASELTRCLQGKSSQLLQGDSIQVSENENNIMNPKGDSSIYIENQEFPFWRTQHSCGNTYLSESQIQSRGKQIDVKNNLQIHEDFMKKSPF
HEHIKTDTEPKPCKGNEYGKIISDGSNQKLPLGEKPHPCGECGRGFSYSPRLPLHPNVHTGEKCFSQSSHLRTHQRIHPGEKLNRCHESG
DCFNKSSFHSYQSNHTGEKSYRCDSCGKGFSSSTGLIIHYRTHTGEKPYKCEECGKCFSQSSNFQCHQRVHTEEKPYKCEECGKGFGWSV
NLRVHQRVHRGEKPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDVCGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHF
RVHTGEKPYKCKECGKGFSQASNLQVHQNVHTGEKRFKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKLHQVIHTGE
KPYKCEECGKGFSWRSNLHAHQRVHSGEKPYKCEQCDKSFSQAIDFRVHQRVHTGEKPYKCGVCGKGFSQSSGLQSHQRVHTGEKPYKCD
VCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKGFGRSLNLRHHQRVHTGEKPHICEECGKAFSLPSNLRVHLGVHTREKLFKCEECGKGF

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>73432_73432_6_RELB-ZNF227_RELB_chr19_45532250_ENST00000505236_ZNF227_chr19_44738854_ENST00000589005_length(amino acids)=1036AA_BP=482
MLRSGPASGPSVPTGRAMPSRRVARPPAAPELGALGSPDLSSLSLAVSRSTEIIDEYIKENGFGLDGGQPGPGEGLPRLVSRGAASLSTV
TLGPVAPPATPPPWGCPLGRLVSPAPGPGPQPHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTAC
LVWKDWPHRVHPHSLVGKDCTDGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQAS
YRDQQGQMRRMDPVLSEPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQKGSKHQNKMETLQKFALKYLSNQELSCWQIWKQV
ASELTRCLQGKSSQLLQGDSIQVSENENNIMNPKGDSSIYIENQEFPFWRTQHSCGNTYLSESQIQSRGKQIDVKNNLQIHEDFMKKSPF
HEHIKTDTEPKPCKGNEYGKIISDGSNQKLPLGEKPHPCGECGRGFSYSPRLPLHPNVHTGEKCFSQSSHLRTHQRIHPGEKLNRCHESG
DCFNKSSFHSYQSNHTGEKSYRCDSCGKGFSSSTGLIIHYRTHTGEKPYKCEECGKCFSQSSNFQCHQRVHTEEKPYKCEECGKGFGWSV
NLRVHQRVHRGEKPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDVCGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHF
RVHTGEKPYKCKECGKGFSQASNLQVHQNVHTGEKRFKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKLHQVIHTGE
KPYKCEECGKGFSWRSNLHAHQRVHSGEKPYKCEQCDKSFSQAIDFRVHQRVHTGEKPYKCGVCGKGFSQSSGLQSHQRVHTGEKPYKCD
VCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKGFGRSLNLRHHQRVHTGEKPHICEECGKAFSLPSNLRVHLGVHTREKLFKCEECGKGF

--------------------------------------------------------------

>73432_73432_7_RELB-ZNF227_RELB_chr19_45532250_ENST00000505236_ZNF227_chr19_44738855_ENST00000391961_length(amino acids)=1036AA_BP=482
MLRSGPASGPSVPTGRAMPSRRVARPPAAPELGALGSPDLSSLSLAVSRSTEIIDEYIKENGFGLDGGQPGPGEGLPRLVSRGAASLSTV
TLGPVAPPATPPPWGCPLGRLVSPAPGPGPQPHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTAC
LVWKDWPHRVHPHSLVGKDCTDGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQAS
YRDQQGQMRRMDPVLSEPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQKGSKHQNKMETLQKFALKYLSNQELSCWQIWKQV
ASELTRCLQGKSSQLLQGDSIQVSENENNIMNPKGDSSIYIENQEFPFWRTQHSCGNTYLSESQIQSRGKQIDVKNNLQIHEDFMKKSPF
HEHIKTDTEPKPCKGNEYGKIISDGSNQKLPLGEKPHPCGECGRGFSYSPRLPLHPNVHTGEKCFSQSSHLRTHQRIHPGEKLNRCHESG
DCFNKSSFHSYQSNHTGEKSYRCDSCGKGFSSSTGLIIHYRTHTGEKPYKCEECGKCFSQSSNFQCHQRVHTEEKPYKCEECGKGFGWSV
NLRVHQRVHRGEKPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDVCGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHF
RVHTGEKPYKCKECGKGFSQASNLQVHQNVHTGEKRFKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKLHQVIHTGE
KPYKCEECGKGFSWRSNLHAHQRVHSGEKPYKCEQCDKSFSQAIDFRVHQRVHTGEKPYKCGVCGKGFSQSSGLQSHQRVHTGEKPYKCD
VCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKGFGRSLNLRHHQRVHTGEKPHICEECGKAFSLPSNLRVHLGVHTREKLFKCEECGKGF

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>73432_73432_8_RELB-ZNF227_RELB_chr19_45532250_ENST00000505236_ZNF227_chr19_44738855_ENST00000589005_length(amino acids)=1036AA_BP=482
MLRSGPASGPSVPTGRAMPSRRVARPPAAPELGALGSPDLSSLSLAVSRSTEIIDEYIKENGFGLDGGQPGPGEGLPRLVSRGAASLSTV
TLGPVAPPATPPPWGCPLGRLVSPAPGPGPQPHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTAC
LVWKDWPHRVHPHSLVGKDCTDGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQAS
YRDQQGQMRRMDPVLSEPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQKGSKHQNKMETLQKFALKYLSNQELSCWQIWKQV
ASELTRCLQGKSSQLLQGDSIQVSENENNIMNPKGDSSIYIENQEFPFWRTQHSCGNTYLSESQIQSRGKQIDVKNNLQIHEDFMKKSPF
HEHIKTDTEPKPCKGNEYGKIISDGSNQKLPLGEKPHPCGECGRGFSYSPRLPLHPNVHTGEKCFSQSSHLRTHQRIHPGEKLNRCHESG
DCFNKSSFHSYQSNHTGEKSYRCDSCGKGFSSSTGLIIHYRTHTGEKPYKCEECGKCFSQSSNFQCHQRVHTEEKPYKCEECGKGFGWSV
NLRVHQRVHRGEKPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDVCGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHF
RVHTGEKPYKCKECGKGFSQASNLQVHQNVHTGEKRFKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKLHQVIHTGE
KPYKCEECGKGFSWRSNLHAHQRVHSGEKPYKCEQCDKSFSQAIDFRVHQRVHTGEKPYKCGVCGKGFSQSSGLQSHQRVHTGEKPYKCD
VCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKGFGRSLNLRHHQRVHTGEKPHICEECGKAFSLPSNLRVHLGVHTREKLFKCEECGKGF

--------------------------------------------------------------

>73432_73432_9_RELB-ZNF227_RELB_chr19_45532250_ENST00000540120_ZNF227_chr19_44738854_ENST00000391961_length(amino acids)=1039AA_BP=485
MLRSGPASGPSVPTGRAMPSRRVARPPAAPELGALGSPDLSSLSLAVSRSTDELEIIDEYIKENGFGLDGGQPGPGEGLPRLVSRGAASL
STVTLGPVAPPATPPPWGCPLGRLVSPAPGPGPQPHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEV
TACLVWKDWPHRVHPHSLVGKDCTDGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICF
QASYRDQQGQMRRMDPVLSEPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQKGSKHQNKMETLQKFALKYLSNQELSCWQIW
KQVASELTRCLQGKSSQLLQGDSIQVSENENNIMNPKGDSSIYIENQEFPFWRTQHSCGNTYLSESQIQSRGKQIDVKNNLQIHEDFMKK
SPFHEHIKTDTEPKPCKGNEYGKIISDGSNQKLPLGEKPHPCGECGRGFSYSPRLPLHPNVHTGEKCFSQSSHLRTHQRIHPGEKLNRCH
ESGDCFNKSSFHSYQSNHTGEKSYRCDSCGKGFSSSTGLIIHYRTHTGEKPYKCEECGKCFSQSSNFQCHQRVHTEEKPYKCEECGKGFG
WSVNLRVHQRVHRGEKPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDVCGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLH
IHFRVHTGEKPYKCKECGKGFSQASNLQVHQNVHTGEKRFKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKLHQVIH
TGEKPYKCEECGKGFSWRSNLHAHQRVHSGEKPYKCEQCDKSFSQAIDFRVHQRVHTGEKPYKCGVCGKGFSQSSGLQSHQRVHTGEKPY
KCDVCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKGFGRSLNLRHHQRVHTGEKPHICEECGKAFSLPSNLRVHLGVHTREKLFKCEECG

--------------------------------------------------------------

>73432_73432_10_RELB-ZNF227_RELB_chr19_45532250_ENST00000540120_ZNF227_chr19_44738854_ENST00000589005_length(amino acids)=1039AA_BP=485
MLRSGPASGPSVPTGRAMPSRRVARPPAAPELGALGSPDLSSLSLAVSRSTDELEIIDEYIKENGFGLDGGQPGPGEGLPRLVSRGAASL
STVTLGPVAPPATPPPWGCPLGRLVSPAPGPGPQPHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEV
TACLVWKDWPHRVHPHSLVGKDCTDGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICF
QASYRDQQGQMRRMDPVLSEPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQKGSKHQNKMETLQKFALKYLSNQELSCWQIW
KQVASELTRCLQGKSSQLLQGDSIQVSENENNIMNPKGDSSIYIENQEFPFWRTQHSCGNTYLSESQIQSRGKQIDVKNNLQIHEDFMKK
SPFHEHIKTDTEPKPCKGNEYGKIISDGSNQKLPLGEKPHPCGECGRGFSYSPRLPLHPNVHTGEKCFSQSSHLRTHQRIHPGEKLNRCH
ESGDCFNKSSFHSYQSNHTGEKSYRCDSCGKGFSSSTGLIIHYRTHTGEKPYKCEECGKCFSQSSNFQCHQRVHTEEKPYKCEECGKGFG
WSVNLRVHQRVHRGEKPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDVCGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLH
IHFRVHTGEKPYKCKECGKGFSQASNLQVHQNVHTGEKRFKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKLHQVIH
TGEKPYKCEECGKGFSWRSNLHAHQRVHSGEKPYKCEQCDKSFSQAIDFRVHQRVHTGEKPYKCGVCGKGFSQSSGLQSHQRVHTGEKPY
KCDVCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKGFGRSLNLRHHQRVHTGEKPHICEECGKAFSLPSNLRVHLGVHTREKLFKCEECG

--------------------------------------------------------------

>73432_73432_11_RELB-ZNF227_RELB_chr19_45532250_ENST00000540120_ZNF227_chr19_44738855_ENST00000391961_length(amino acids)=1039AA_BP=485
MLRSGPASGPSVPTGRAMPSRRVARPPAAPELGALGSPDLSSLSLAVSRSTDELEIIDEYIKENGFGLDGGQPGPGEGLPRLVSRGAASL
STVTLGPVAPPATPPPWGCPLGRLVSPAPGPGPQPHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEV
TACLVWKDWPHRVHPHSLVGKDCTDGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICF
QASYRDQQGQMRRMDPVLSEPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQKGSKHQNKMETLQKFALKYLSNQELSCWQIW
KQVASELTRCLQGKSSQLLQGDSIQVSENENNIMNPKGDSSIYIENQEFPFWRTQHSCGNTYLSESQIQSRGKQIDVKNNLQIHEDFMKK
SPFHEHIKTDTEPKPCKGNEYGKIISDGSNQKLPLGEKPHPCGECGRGFSYSPRLPLHPNVHTGEKCFSQSSHLRTHQRIHPGEKLNRCH
ESGDCFNKSSFHSYQSNHTGEKSYRCDSCGKGFSSSTGLIIHYRTHTGEKPYKCEECGKCFSQSSNFQCHQRVHTEEKPYKCEECGKGFG
WSVNLRVHQRVHRGEKPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDVCGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLH
IHFRVHTGEKPYKCKECGKGFSQASNLQVHQNVHTGEKRFKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKLHQVIH
TGEKPYKCEECGKGFSWRSNLHAHQRVHSGEKPYKCEQCDKSFSQAIDFRVHQRVHTGEKPYKCGVCGKGFSQSSGLQSHQRVHTGEKPY
KCDVCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKGFGRSLNLRHHQRVHTGEKPHICEECGKAFSLPSNLRVHLGVHTREKLFKCEECG

--------------------------------------------------------------

>73432_73432_12_RELB-ZNF227_RELB_chr19_45532250_ENST00000540120_ZNF227_chr19_44738855_ENST00000589005_length(amino acids)=1039AA_BP=485
MLRSGPASGPSVPTGRAMPSRRVARPPAAPELGALGSPDLSSLSLAVSRSTDELEIIDEYIKENGFGLDGGQPGPGEGLPRLVSRGAASL
STVTLGPVAPPATPPPWGCPLGRLVSPAPGPGPQPHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEV
TACLVWKDWPHRVHPHSLVGKDCTDGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICF
QASYRDQQGQMRRMDPVLSEPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQKGSKHQNKMETLQKFALKYLSNQELSCWQIW
KQVASELTRCLQGKSSQLLQGDSIQVSENENNIMNPKGDSSIYIENQEFPFWRTQHSCGNTYLSESQIQSRGKQIDVKNNLQIHEDFMKK
SPFHEHIKTDTEPKPCKGNEYGKIISDGSNQKLPLGEKPHPCGECGRGFSYSPRLPLHPNVHTGEKCFSQSSHLRTHQRIHPGEKLNRCH
ESGDCFNKSSFHSYQSNHTGEKSYRCDSCGKGFSSSTGLIIHYRTHTGEKPYKCEECGKCFSQSSNFQCHQRVHTEEKPYKCEECGKGFG
WSVNLRVHQRVHRGEKPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDVCGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLH
IHFRVHTGEKPYKCKECGKGFSQASNLQVHQNVHTGEKRFKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKLHQVIH
TGEKPYKCEECGKGFSWRSNLHAHQRVHSGEKPYKCEQCDKSFSQAIDFRVHQRVHTGEKPYKCGVCGKGFSQSSGLQSHQRVHTGEKPY
KCDVCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKGFGRSLNLRHHQRVHTGEKPHICEECGKAFSLPSNLRVHLGVHTREKLFKCEECG

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:45532250/chr19:44738855)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RELB

chr19:45532250

chr19:44738854

ENST00000221452

40_68

330.3333333333333

580.0

Region

Note=Leucine-zipper

Hgene

RELB

chr19:45532250

chr19:44738854

ENST00000540120

40_68

330.3333333333333

580.0

Region

Note=Leucine-zipper

Hgene

RELB

chr19:45532250

chr19:44738855

ENST00000221452

40_68

330.3333333333333

580.0

Region

Note=Leucine-zipper

Hgene

RELB

chr19:45532250

chr19:44738855

ENST00000540120

40_68

330.3333333333333

580.0

Region

Note=Leucine-zipper

Tgene

ZNF227

chr19:45532250

chr19:44738854

ENST00000313040

250_272

90.33333333333333

800.0

Zinc finger

C2H2-type 1

Tgene

ZNF227

chr19:45532250

chr19:44738854

ENST00000313040

269_291

90.33333333333333

800.0

Zinc finger

C2H2-type 2

Tgene

ZNF227

chr19:45532250

chr19:44738854

ENST00000313040

324_346

90.33333333333333

800.0

Zinc finger

C2H2-type 3

Tgene

ZNF227

chr19:45532250

chr19:44738854

ENST00000313040

352_374

90.33333333333333

800.0

Zinc finger

C2H2-type 4

Tgene

ZNF227

chr19:45532250

chr19:44738854

ENST00000313040

380_402

90.33333333333333

800.0

Zinc finger

C2H2-type 5

Tgene

ZNF227

chr19:45532250

chr19:44738854

ENST00000313040

408_430

90.33333333333333

800.0

Zinc finger

C2H2-type 6

Tgene

ZNF227

chr19:45532250

chr19:44738854

ENST00000313040

436_458

90.33333333333333

800.0

Zinc finger

C2H2-type 7

Tgene

ZNF227

chr19:45532250

chr19:44738854

ENST00000313040

464_486

90.33333333333333

800.0

Zinc finger

C2H2-type 8

Tgene

ZNF227

chr19:45532250

chr19:44738854

ENST00000313040

492_514

90.33333333333333

800.0

Zinc finger

C2H2-type 9

Tgene

ZNF227

chr19:45532250

chr19:44738854

ENST00000313040

520_542

90.33333333333333

800.0

Zinc finger

C2H2-type 10

Tgene

ZNF227

chr19:45532250

chr19:44738854

ENST00000313040

548_570

90.33333333333333

800.0

Zinc finger

C2H2-type 11

Tgene

ZNF227

chr19:45532250

chr19:44738854

ENST00000313040

576_598

90.33333333333333

800.0

Zinc finger

C2H2-type 12

Tgene

ZNF227

chr19:45532250

chr19:44738854

ENST00000313040

604_626

90.33333333333333

800.0

Zinc finger

C2H2-type 13

Tgene

ZNF227

chr19:45532250

chr19:44738854

ENST00000313040

632_654

90.33333333333333

800.0

Zinc finger

C2H2-type 14

Tgene

ZNF227

chr19:45532250

chr19:44738854

ENST00000313040

660_682

90.33333333333333

800.0

Zinc finger

C2H2-type 15

Tgene

ZNF227

chr19:45532250

chr19:44738854

ENST00000313040

688_710

90.33333333333333

800.0

Zinc finger

C2H2-type 16

Tgene

ZNF227

chr19:45532250

chr19:44738854

ENST00000313040

716_738

90.33333333333333

800.0

Zinc finger

C2H2-type 17

Tgene

ZNF227

chr19:45532250

chr19:44738854

ENST00000313040

744_766

90.33333333333333

800.0

Zinc finger

C2H2-type 18

Tgene

ZNF227

chr19:45532250

chr19:44738854

ENST00000313040

772_794

90.33333333333333

800.0

Zinc finger

C2H2-type 19

Tgene

ZNF227

chr19:45532250

chr19:44738855

ENST00000313040

250_272

90.33333333333333

800.0

Zinc finger

C2H2-type 1

Tgene

ZNF227

chr19:45532250

chr19:44738855

ENST00000313040

269_291

90.33333333333333

800.0

Zinc finger

C2H2-type 2

Tgene

ZNF227

chr19:45532250

chr19:44738855

ENST00000313040

324_346

90.33333333333333

800.0

Zinc finger

C2H2-type 3

Tgene

ZNF227

chr19:45532250

chr19:44738855

ENST00000313040

352_374

90.33333333333333

800.0

Zinc finger

C2H2-type 4

Tgene

ZNF227

chr19:45532250

chr19:44738855

ENST00000313040

380_402

90.33333333333333

800.0

Zinc finger

C2H2-type 5

Tgene

ZNF227

chr19:45532250

chr19:44738855

ENST00000313040

408_430

90.33333333333333

800.0

Zinc finger

C2H2-type 6

Tgene

ZNF227

chr19:45532250

chr19:44738855

ENST00000313040

436_458

90.33333333333333

800.0

Zinc finger

C2H2-type 7

Tgene

ZNF227

chr19:45532250

chr19:44738855

ENST00000313040

464_486

90.33333333333333

800.0

Zinc finger

C2H2-type 8

Tgene

ZNF227

chr19:45532250

chr19:44738855

ENST00000313040

492_514

90.33333333333333

800.0

Zinc finger

C2H2-type 9

Tgene

ZNF227

chr19:45532250

chr19:44738855

ENST00000313040

520_542

90.33333333333333

800.0

Zinc finger

C2H2-type 10

Tgene

ZNF227

chr19:45532250

chr19:44738855

ENST00000313040

548_570

90.33333333333333

800.0

Zinc finger

C2H2-type 11

Tgene

ZNF227

chr19:45532250

chr19:44738855

ENST00000313040

576_598

90.33333333333333

800.0

Zinc finger

C2H2-type 12

Tgene

ZNF227

chr19:45532250

chr19:44738855

ENST00000313040

604_626

90.33333333333333

800.0

Zinc finger

C2H2-type 13

Tgene

ZNF227

chr19:45532250

chr19:44738855

ENST00000313040

632_654

90.33333333333333

800.0

Zinc finger

C2H2-type 14

Tgene

ZNF227

chr19:45532250

chr19:44738855

ENST00000313040

660_682

90.33333333333333

800.0

Zinc finger

C2H2-type 15

Tgene

ZNF227

chr19:45532250

chr19:44738855

ENST00000313040

688_710

90.33333333333333

800.0

Zinc finger

C2H2-type 16

Tgene

ZNF227

chr19:45532250

chr19:44738855

ENST00000313040

716_738

90.33333333333333

800.0

Zinc finger

C2H2-type 17

Tgene

ZNF227

chr19:45532250

chr19:44738855

ENST00000313040

744_766

90.33333333333333

800.0

Zinc finger

C2H2-type 18

Tgene

ZNF227

chr19:45532250

chr19:44738855

ENST00000313040

772_794

90.33333333333333

800.0

Zinc finger

C2H2-type 19

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RELB

chr19:45532250

chr19:44738854

ENST00000221452

125_440

330.3333333333333

580.0

Domain

RHD

Hgene

RELB

chr19:45532250

chr19:44738854

ENST00000540120

125_440

330.3333333333333

580.0

Domain

RHD

Hgene

RELB

chr19:45532250

chr19:44738855

ENST00000221452

125_440

330.3333333333333

580.0

Domain

RHD

Hgene

RELB

chr19:45532250

chr19:44738855

ENST00000540120

125_440

330.3333333333333

580.0

Domain

RHD

Hgene

RELB

chr19:45532250

chr19:44738854

ENST00000221452

433_438

330.3333333333333

580.0

Motif

Nuclear localization signal

Hgene

RELB

chr19:45532250

chr19:44738854

ENST00000540120

433_438

330.3333333333333

580.0

Motif

Nuclear localization signal

Hgene

RELB

chr19:45532250

chr19:44738855

ENST00000221452

433_438

330.3333333333333

580.0

Motif

Nuclear localization signal

Hgene

RELB

chr19:45532250

chr19:44738855

ENST00000540120

433_438

330.3333333333333

580.0

Motif

Nuclear localization signal

Tgene

ZNF227

chr19:45532250

chr19:44738854

ENST00000313040

23_94

90.33333333333333

800.0

Domain

KRAB

Tgene

ZNF227

chr19:45532250

chr19:44738855

ENST00000313040

23_94

90.33333333333333

800.0

Domain

KRAB

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1820_RELB_45532250_ZNF227_44738855_ranked_0.pdb	RELB	45532250	45532250	ENST00000391961	ZNF227	chr19	44738855	+	MLRSGPASGPSVPTGRAMPSRRVARPPAAPELGALGSPDLSSLSLAVSRSTDELEIIDEYIKENGFGLDGGQPGPGEGLPRLVSRGAASL STVTLGPVAPPATPPPWGCPLGRLVSPAPGPGPQPHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEV TACLVWKDWPHRVHPHSLVGKDCTDGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICF QASYRDQQGQMRRMDPVLSEPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQKGSKHQNKMETLQKFALKYLSNQELSCWQIW KQVASELTRCLQGKSSQLLQGDSIQVSENENNIMNPKGDSSIYIENQEFPFWRTQHSCGNTYLSESQIQSRGKQIDVKNNLQIHEDFMKK SPFHEHIKTDTEPKPCKGNEYGKIISDGSNQKLPLGEKPHPCGECGRGFSYSPRLPLHPNVHTGEKCFSQSSHLRTHQRIHPGEKLNRCH ESGDCFNKSSFHSYQSNHTGEKSYRCDSCGKGFSSSTGLIIHYRTHTGEKPYKCEECGKCFSQSSNFQCHQRVHTEEKPYKCEECGKGFG WSVNLRVHQRVHRGEKPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDVCGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLH IHFRVHTGEKPYKCKECGKGFSQASNLQVHQNVHTGEKRFKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKLHQVIH TGEKPYKCEECGKGFSWRSNLHAHQRVHSGEKPYKCEQCDKSFSQAIDFRVHQRVHTGEKPYKCGVCGKGFSQSSGLQSHQRVHTGEKPY KCDVCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKGFGRSLNLRHHQRVHTGEKPHICEECGKAFSLPSNLRVHLGVHTREKLFKCEECG	1039

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

RELB_pLDDT.png

ZNF227_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
RELB
ZNF227

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to RELB-ZNF227

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to RELB-ZNF227

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source