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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:REPS2-TXLNG

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: REPS2-TXLNG
FusionPDB ID: 73484
FusionGDB2.0 ID: 73484
HgeneTgene
Gene symbol

REPS2

TXLNG

Gene ID

9185

55787

Gene nameRALBP1 associated Eps domain containing 2taxilin gamma
SynonymsPOB1CXorf15|ELRG|FIAT|LSR5|TXLNGX
Cytomap

Xp22.2

Xp22.2

Type of geneprotein-codingprotein-coding
DescriptionralBP1-associated Eps domain-containing protein 2RALBP1-interacting protein 2partner of Ral-binding protein 1partner of RalBP1gamma-taxilinenvironmental LPS-respondingenvironmental lipopolysaccharide-responding gene proteinfactor inhibiting ATF4-mediated transcriptionfactor inhibiting activating transcription factor 4 (ATF4)-mediated transcriptionlipopolysaccharide specific
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000469714, ENST00000303843, 
ENST00000357277, ENST00000380064, 
ENST00000380122, ENST00000398155, 
ENST00000485153, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 9 X 10=11703 X 7 X 7=147
# samples 199
** MAII scorelog2(19/1170*10)=-2.62243720613982
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/147*10)=-0.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: REPS2 [Title/Abstract] AND TXLNG [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)REPS2(17024467)-TXLNG(16836697), # samples:3
REPS2(17121902)-TXLNG(16836697), # samples:3
REPS2(17152030)-TXLNG(16852406), # samples:3
Anticipated loss of major functional domain due to fusion event.REPS2-TXLNG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
REPS2-TXLNG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
REPS2-TXLNG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
REPS2-TXLNG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
REPS2-TXLNG seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
REPS2-TXLNG seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across REPS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TXLNG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5LO-01AREPS2chrX

17024467

-TXLNGchrX

16836697

+
ChimerDB4ACCTCGA-OR-A5LO-01AREPS2chrX

17024467

+TXLNGchrX

16836697

+
ChimerDB4COADTCGA-AZ-4614-01AREPS2chrX

17047746

-TXLNGchrX

16859551

+
ChimerDB4COADTCGA-AZ-4614-01AREPS2chrX

17047746

+TXLNGchrX

16859551

+
ChimerDB4LIHCTCGA-BC-A10T-01AREPS2chrX

17121902

-TXLNGchrX

16836697

+
ChimerDB4LIHCTCGA-BC-A10T-01AREPS2chrX

17121902

+TXLNGchrX

16836697

+
ChimerDB4PRADTCGA-VP-A87H-01AREPS2chrX

16965257

-TXLNGchrX

16836697

+
ChimerDB4PRADTCGA-VP-A87HREPS2chrX

16965257

+TXLNGchrX

16836697

+
ChimerDB4PRADTCGA-XJ-A9DX-01AREPS2chrX

17152030

-TXLNGchrX

16852406

+
ChimerDB4PRADTCGA-XJ-A9DX-01AREPS2chrX

17152030

+TXLNGchrX

16852406

+
ChimerDB4PRADTCGA-XJ-A9DXREPS2chrX

17152030

+TXLNGchrX

16852406

+
ChimerDB4STADTCGA-VQ-A922-01AREPS2chrX

17121902

+TXLNGchrX

16847699

+
ChimerDB4STADTCGA-VQ-A922REPS2chrX

17121902

+TXLNGchrX

16847698

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000357277REPS2chrX17121902+ENST00000380122TXLNGchrX16836697+5987174917132331020
ENST00000303843REPS2chrX17121902+ENST00000380122TXLNGchrX16836697+58131575030591019
ENST00000380064REPS2chrX17121902+ENST00000380122TXLNGchrX16836697+54151177672661864
ENST00000357277REPS2chrX17152030+ENST00000380122TXLNGchrX16852406+518918331712435754
ENST00000357277REPS2chrX17152030+ENST00000398155TXLNGchrX16852406+518718331712435754
ENST00000303843REPS2chrX17152030+ENST00000380122TXLNGchrX16852406+5015165902261753
ENST00000303843REPS2chrX17152030+ENST00000398155TXLNGchrX16852406+5013165902261753
ENST00000380064REPS2chrX17152030+ENST00000380122TXLNGchrX16852406+46171261671863598
ENST00000380064REPS2chrX17152030+ENST00000398155TXLNGchrX16852406+46151261671863598
ENST00000357277REPS2chrX17121902+ENST00000380122TXLNGchrX16847699+542017491712666831
ENST00000357277REPS2chrX17121902+ENST00000398155TXLNGchrX16847699+541817491712666831
ENST00000303843REPS2chrX17121902+ENST00000380122TXLNGchrX16847699+5246157502492830
ENST00000303843REPS2chrX17121902+ENST00000398155TXLNGchrX16847699+5244157502492830
ENST00000380064REPS2chrX17121902+ENST00000380122TXLNGchrX16847699+48481177672094675
ENST00000380064REPS2chrX17121902+ENST00000398155TXLNGchrX16847699+48461177672094675
ENST00000357277REPS2chrX17121902+ENST00000380122TXLNGchrX16847698+542017491712666831
ENST00000357277REPS2chrX17121902+ENST00000398155TXLNGchrX16847698+541817491712666831
ENST00000303843REPS2chrX17121902+ENST00000380122TXLNGchrX16847698+5246157502492830
ENST00000303843REPS2chrX17121902+ENST00000398155TXLNGchrX16847698+5244157502492830
ENST00000380064REPS2chrX17121902+ENST00000380122TXLNGchrX16847698+48481177672094675
ENST00000380064REPS2chrX17121902+ENST00000398155TXLNGchrX16847698+48461177672094675
ENST00000357277REPS2chrX17047746+ENST00000398155TXLNGchrX16859551+40329421711280369
ENST00000303843REPS2chrX17047746+ENST00000398155TXLNGchrX16859551+385876801106368
ENST00000380064REPS2chrX17047746+ENST00000398155TXLNGchrX16859551+364355367891274
ENST00000357277REPS2chrX16965257+ENST00000380122TXLNGchrX16836697+46824441711928585
ENST00000303843REPS2chrX16965257+ENST00000380122TXLNGchrX16836697+451127301757585

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357277ENST00000380122REPS2chrX17121902+TXLNGchrX16836697+0.0006722750.9993278
ENST00000303843ENST00000380122REPS2chrX17121902+TXLNGchrX16836697+0.0004732610.99952674
ENST00000380064ENST00000380122REPS2chrX17121902+TXLNGchrX16836697+0.0010299320.99897003
ENST00000357277ENST00000380122REPS2chrX17152030+TXLNGchrX16852406+0.0003045450.99969554
ENST00000357277ENST00000398155REPS2chrX17152030+TXLNGchrX16852406+0.0003094930.99969053
ENST00000303843ENST00000380122REPS2chrX17152030+TXLNGchrX16852406+0.000208430.99979156
ENST00000303843ENST00000398155REPS2chrX17152030+TXLNGchrX16852406+0.0002113190.9997887
ENST00000380064ENST00000380122REPS2chrX17152030+TXLNGchrX16852406+0.0005755760.99942446
ENST00000380064ENST00000398155REPS2chrX17152030+TXLNGchrX16852406+0.0005806540.99941933
ENST00000357277ENST00000380122REPS2chrX17121902+TXLNGchrX16847699+0.0003223910.99967766
ENST00000357277ENST00000398155REPS2chrX17121902+TXLNGchrX16847699+0.000327670.9996723
ENST00000303843ENST00000380122REPS2chrX17121902+TXLNGchrX16847699+0.0002433920.99975663
ENST00000303843ENST00000398155REPS2chrX17121902+TXLNGchrX16847699+0.0002472680.9997527
ENST00000380064ENST00000380122REPS2chrX17121902+TXLNGchrX16847699+0.0008325380.99916744
ENST00000380064ENST00000398155REPS2chrX17121902+TXLNGchrX16847699+0.0008430960.99915695
ENST00000357277ENST00000380122REPS2chrX17121902+TXLNGchrX16847698+0.0003223910.99967766
ENST00000357277ENST00000398155REPS2chrX17121902+TXLNGchrX16847698+0.000327670.9996723
ENST00000303843ENST00000380122REPS2chrX17121902+TXLNGchrX16847698+0.0002433920.99975663
ENST00000303843ENST00000398155REPS2chrX17121902+TXLNGchrX16847698+0.0002472680.9997527
ENST00000380064ENST00000380122REPS2chrX17121902+TXLNGchrX16847698+0.0008325380.99916744
ENST00000380064ENST00000398155REPS2chrX17121902+TXLNGchrX16847698+0.0008430960.99915695
ENST00000357277ENST00000398155REPS2chrX17047746+TXLNGchrX16859551+0.0002986420.9997013
ENST00000303843ENST00000398155REPS2chrX17047746+TXLNGchrX16859551+0.0002280260.999772
ENST00000380064ENST00000398155REPS2chrX17047746+TXLNGchrX16859551+0.0010313780.9989686
ENST00000357277ENST00000380122REPS2chrX16965257+TXLNGchrX16836697+0.000395390.99960464
ENST00000303843ENST00000380122REPS2chrX16965257+TXLNGchrX16836697+0.0003686370.9996314

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>73484_73484_1_REPS2-TXLNG_REPS2_chrX_16965257_ENST00000303843_TXLNG_chrX_16836697_ENST00000380122_length(amino acids)=585AA_BP=91
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QFEIGTMEEAGICGLGVKADMLCNSQSNDILQHQGSNCGGTSNKHSLEEDEGSDFITENRNLVSPAYCTQESREEIPGGEARTDPPDGQQ
DSECNRNKEKTLGKEVLLLMQALNTLSTPEEKLAALCKKYADLLEESRSVQKQMKILQKKQAQIVKEKVHLQSEHSKAILARSKLESLCR
ELQRHNKTLKEENMQQAREEEERRKEATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQL
VDAKLQQTTQLIKEADEKHQREREFLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLE
KETIIWRTKWENNNKALLQMAEEKTVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTAL

--------------------------------------------------------------

>73484_73484_2_REPS2-TXLNG_REPS2_chrX_16965257_ENST00000357277_TXLNG_chrX_16836697_ENST00000380122_length(amino acids)=585AA_BP=91
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QFEIGTMEEAGICGLGVKADMLCNSQSNDILQHQGSNCGGTSNKHSLEEDEGSDFITENRNLVSPAYCTQESREEIPGGEARTDPPDGQQ
DSECNRNKEKTLGKEVLLLMQALNTLSTPEEKLAALCKKYADLLEESRSVQKQMKILQKKQAQIVKEKVHLQSEHSKAILARSKLESLCR
ELQRHNKTLKEENMQQAREEEERRKEATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQL
VDAKLQQTTQLIKEADEKHQREREFLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLE
KETIIWRTKWENNNKALLQMAEEKTVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTAL

--------------------------------------------------------------

>73484_73484_3_REPS2-TXLNG_REPS2_chrX_17047746_ENST00000303843_TXLNG_chrX_16859551_ENST00000398155_length(amino acids)=368AA_BP=256
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRKTVRDKEYKALQIK
LERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTALDSHKELNTSSKRALGAHLEAEPKSQRSAVQKPPSTGS

--------------------------------------------------------------

>73484_73484_4_REPS2-TXLNG_REPS2_chrX_17047746_ENST00000357277_TXLNG_chrX_16859551_ENST00000398155_length(amino acids)=369AA_BP=257
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRKTVRDKEYKALQI
KLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTALDSHKELNTSSKRALGAHLEAEPKSQRSAVQKPPSTG

--------------------------------------------------------------

>73484_73484_5_REPS2-TXLNG_REPS2_chrX_17047746_ENST00000380064_TXLNG_chrX_16859551_ENST00000398155_length(amino acids)=274AA_BP=162
MCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDEDKQET
QSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRKTVRDKEYKALQIKLERL
EKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTALDSHKELNTSSKRALGAHLEAEPKSQRSAVQKPPSTGSAPAI

--------------------------------------------------------------

>73484_73484_6_REPS2-TXLNG_REPS2_chrX_17121902_ENST00000303843_TXLNG_chrX_16836697_ENST00000380122_length(amino acids)=1019AA_BP=525
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSSY
PDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLP
PTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDSN
SLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQFEIGTMEEAGICGLG
VKADMLCNSQSNDILQHQGSNCGGTSNKHSLEEDEGSDFITENRNLVSPAYCTQESREEIPGGEARTDPPDGQQDSECNRNKEKTLGKEV
LLLMQALNTLSTPEEKLAALCKKYADLLEESRSVQKQMKILQKKQAQIVKEKVHLQSEHSKAILARSKLESLCRELQRHNKTLKEENMQQ
AREEEERRKEATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQLVDAKLQQTTQLIKEAD
EKHQREREFLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIIWRTKWENNNKA
LLQMAEEKTVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTALDSHKELNTSSKRALGA

--------------------------------------------------------------

>73484_73484_7_REPS2-TXLNG_REPS2_chrX_17121902_ENST00000303843_TXLNG_chrX_16847698_ENST00000380122_length(amino acids)=830AA_BP=525
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSSY
PDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLP
PTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDSN
SLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQEENMQQAREEEERRK
EATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQLVDAKLQQTTQLIKEADEKHQREREF
LLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIIWRTKWENNNKALLQMAEEKT
VRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTALDSHKELNTSSKRALGAHLEAEPKSQ

--------------------------------------------------------------

>73484_73484_8_REPS2-TXLNG_REPS2_chrX_17121902_ENST00000303843_TXLNG_chrX_16847698_ENST00000398155_length(amino acids)=830AA_BP=525
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSSY
PDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLP
PTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDSN
SLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQEENMQQAREEEERRK
EATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQLVDAKLQQTTQLIKEADEKHQREREF
LLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIIWRTKWENNNKALLQMAEEKT
VRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTALDSHKELNTSSKRALGAHLEAEPKSQ

--------------------------------------------------------------

>73484_73484_9_REPS2-TXLNG_REPS2_chrX_17121902_ENST00000303843_TXLNG_chrX_16847699_ENST00000380122_length(amino acids)=830AA_BP=525
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSSY
PDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLP
PTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDSN
SLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQEENMQQAREEEERRK
EATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQLVDAKLQQTTQLIKEADEKHQREREF
LLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIIWRTKWENNNKALLQMAEEKT
VRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTALDSHKELNTSSKRALGAHLEAEPKSQ

--------------------------------------------------------------

>73484_73484_10_REPS2-TXLNG_REPS2_chrX_17121902_ENST00000303843_TXLNG_chrX_16847699_ENST00000398155_length(amino acids)=830AA_BP=525
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSSY
PDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLP
PTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDSN
SLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQEENMQQAREEEERRK
EATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQLVDAKLQQTTQLIKEADEKHQREREF
LLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIIWRTKWENNNKALLQMAEEKT
VRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTALDSHKELNTSSKRALGAHLEAEPKSQ

--------------------------------------------------------------

>73484_73484_11_REPS2-TXLNG_REPS2_chrX_17121902_ENST00000357277_TXLNG_chrX_16836697_ENST00000380122_length(amino acids)=1020AA_BP=526
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSS
YPDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGL
PPTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDS
NSLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQFEIGTMEEAGICGL
GVKADMLCNSQSNDILQHQGSNCGGTSNKHSLEEDEGSDFITENRNLVSPAYCTQESREEIPGGEARTDPPDGQQDSECNRNKEKTLGKE
VLLLMQALNTLSTPEEKLAALCKKYADLLEESRSVQKQMKILQKKQAQIVKEKVHLQSEHSKAILARSKLESLCRELQRHNKTLKEENMQ
QAREEEERRKEATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQLVDAKLQQTTQLIKEA
DEKHQREREFLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIIWRTKWENNNK
ALLQMAEEKTVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTALDSHKELNTSSKRALG

--------------------------------------------------------------

>73484_73484_12_REPS2-TXLNG_REPS2_chrX_17121902_ENST00000357277_TXLNG_chrX_16847698_ENST00000380122_length(amino acids)=831AA_BP=526
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSS
YPDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGL
PPTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDS
NSLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQEENMQQAREEEERR
KEATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQLVDAKLQQTTQLIKEADEKHQRERE
FLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIIWRTKWENNNKALLQMAEEK
TVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTALDSHKELNTSSKRALGAHLEAEPKS

--------------------------------------------------------------

>73484_73484_13_REPS2-TXLNG_REPS2_chrX_17121902_ENST00000357277_TXLNG_chrX_16847698_ENST00000398155_length(amino acids)=831AA_BP=526
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSS
YPDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGL
PPTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDS
NSLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQEENMQQAREEEERR
KEATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQLVDAKLQQTTQLIKEADEKHQRERE
FLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIIWRTKWENNNKALLQMAEEK
TVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTALDSHKELNTSSKRALGAHLEAEPKS

--------------------------------------------------------------

>73484_73484_14_REPS2-TXLNG_REPS2_chrX_17121902_ENST00000357277_TXLNG_chrX_16847699_ENST00000380122_length(amino acids)=831AA_BP=526
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSS
YPDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGL
PPTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDS
NSLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQEENMQQAREEEERR
KEATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQLVDAKLQQTTQLIKEADEKHQRERE
FLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIIWRTKWENNNKALLQMAEEK
TVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTALDSHKELNTSSKRALGAHLEAEPKS

--------------------------------------------------------------

>73484_73484_15_REPS2-TXLNG_REPS2_chrX_17121902_ENST00000357277_TXLNG_chrX_16847699_ENST00000398155_length(amino acids)=831AA_BP=526
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSS
YPDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGL
PPTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDS
NSLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQEENMQQAREEEERR
KEATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQLVDAKLQQTTQLIKEADEKHQRERE
FLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIIWRTKWENNNKALLQMAEEK
TVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTALDSHKELNTSSKRALGAHLEAEPKS

--------------------------------------------------------------

>73484_73484_16_REPS2-TXLNG_REPS2_chrX_17121902_ENST00000380064_TXLNG_chrX_16836697_ENST00000380122_length(amino acids)=864AA_BP=370
MCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDEDKQET
QSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSSYPDEP
WRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLPPTLQ
PEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATKSGLLPPPP
ALPPRPCPSQFEIGTMEEAGICGLGVKADMLCNSQSNDILQHQGSNCGGTSNKHSLEEDEGSDFITENRNLVSPAYCTQESREEIPGGEA
RTDPPDGQQDSECNRNKEKTLGKEVLLLMQALNTLSTPEEKLAALCKKYADLLEESRSVQKQMKILQKKQAQIVKEKVHLQSEHSKAILA
RSKLESLCRELQRHNKTLKEENMQQAREEEERRKEATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVF
KHKELQQQLVDAKLQQTTQLIKEADEKHQREREFLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEK
MTKKIKKLEKETIIWRTKWENNNKALLQMAEEKTVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLAT

--------------------------------------------------------------

>73484_73484_17_REPS2-TXLNG_REPS2_chrX_17121902_ENST00000380064_TXLNG_chrX_16847698_ENST00000380122_length(amino acids)=675AA_BP=370
MCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDEDKQET
QSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSSYPDEP
WRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLPPTLQ
PEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATKSGLLPPPP
ALPPRPCPSQEENMQQAREEEERRKEATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQL
VDAKLQQTTQLIKEADEKHQREREFLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLE
KETIIWRTKWENNNKALLQMAEEKTVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTAL

--------------------------------------------------------------

>73484_73484_18_REPS2-TXLNG_REPS2_chrX_17121902_ENST00000380064_TXLNG_chrX_16847698_ENST00000398155_length(amino acids)=675AA_BP=370
MCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDEDKQET
QSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSSYPDEP
WRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLPPTLQ
PEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATKSGLLPPPP
ALPPRPCPSQEENMQQAREEEERRKEATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQL
VDAKLQQTTQLIKEADEKHQREREFLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLE
KETIIWRTKWENNNKALLQMAEEKTVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTAL

--------------------------------------------------------------

>73484_73484_19_REPS2-TXLNG_REPS2_chrX_17121902_ENST00000380064_TXLNG_chrX_16847699_ENST00000380122_length(amino acids)=675AA_BP=370
MCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDEDKQET
QSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSSYPDEP
WRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLPPTLQ
PEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATKSGLLPPPP
ALPPRPCPSQEENMQQAREEEERRKEATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQL
VDAKLQQTTQLIKEADEKHQREREFLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLE
KETIIWRTKWENNNKALLQMAEEKTVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTAL

--------------------------------------------------------------

>73484_73484_20_REPS2-TXLNG_REPS2_chrX_17121902_ENST00000380064_TXLNG_chrX_16847699_ENST00000398155_length(amino acids)=675AA_BP=370
MCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDEDKQET
QSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSSYPDEP
WRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLPPTLQ
PEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATKSGLLPPPP
ALPPRPCPSQEENMQQAREEEERRKEATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQL
VDAKLQQTTQLIKEADEKHQREREFLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLE
KETIIWRTKWENNNKALLQMAEEKTVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTAL

--------------------------------------------------------------

>73484_73484_21_REPS2-TXLNG_REPS2_chrX_17152030_ENST00000303843_TXLNG_chrX_16852406_ENST00000380122_length(amino acids)=753AA_BP=553
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSSY
PDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLP
PTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDSN
SLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQSEQVSEAELLPQLSR
APSQAAESSPAKKLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIIWRTKWEN
NNKALLQMAEEKTVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTALDSHKELNTSSKR

--------------------------------------------------------------

>73484_73484_22_REPS2-TXLNG_REPS2_chrX_17152030_ENST00000303843_TXLNG_chrX_16852406_ENST00000398155_length(amino acids)=753AA_BP=553
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSSY
PDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLP
PTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDSN
SLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQSEQVSEAELLPQLSR
APSQAAESSPAKKLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIIWRTKWEN
NNKALLQMAEEKTVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTALDSHKELNTSSKR

--------------------------------------------------------------

>73484_73484_23_REPS2-TXLNG_REPS2_chrX_17152030_ENST00000357277_TXLNG_chrX_16852406_ENST00000380122_length(amino acids)=754AA_BP=554
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSS
YPDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGL
PPTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDS
NSLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQSEQVSEAELLPQLS
RAPSQAAESSPAKKLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIIWRTKWE
NNNKALLQMAEEKTVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTALDSHKELNTSSK

--------------------------------------------------------------

>73484_73484_24_REPS2-TXLNG_REPS2_chrX_17152030_ENST00000357277_TXLNG_chrX_16852406_ENST00000398155_length(amino acids)=754AA_BP=554
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSS
YPDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGL
PPTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDS
NSLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQSEQVSEAELLPQLS
RAPSQAAESSPAKKLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIIWRTKWE
NNNKALLQMAEEKTVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTALDSHKELNTSSK

--------------------------------------------------------------

>73484_73484_25_REPS2-TXLNG_REPS2_chrX_17152030_ENST00000380064_TXLNG_chrX_16852406_ENST00000380122_length(amino acids)=598AA_BP=398
MCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDEDKQET
QSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSSYPDEP
WRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLPPTLQ
PEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATKSGLLPPPP
ALPPRPCPSQSEQVSEAELLPQLSRAPSQAAESSPAKKLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQ
EMEKMTKKIKKLEKETIIWRTKWENNNKALLQMAEEKTVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANR

--------------------------------------------------------------

>73484_73484_26_REPS2-TXLNG_REPS2_chrX_17152030_ENST00000380064_TXLNG_chrX_16852406_ENST00000398155_length(amino acids)=598AA_BP=398
MCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDEDKQET
QSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSSYPDEP
WRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLPPTLQ
PEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATKSGLLPPPP
ALPPRPCPSQSEQVSEAELLPQLSRAPSQAAESSPAKKLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQ
EMEKMTKKIKKLEKETIIWRTKWENNNKALLQMAEEKTVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANR

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:17024467/chrX:16836697)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneREPS2chrX:17121902chrX:16836697ENST00000303843+1418328_339525.0660.0Calcium bindingOntology_term=ECO:0000255
HgeneREPS2chrX:17121902chrX:16836697ENST00000357277+1418328_339526.0661.0Calcium bindingOntology_term=ECO:0000255
HgeneREPS2chrX:17121902chrX:16847698ENST00000303843+1418328_339525.0660.0Calcium bindingOntology_term=ECO:0000255
HgeneREPS2chrX:17121902chrX:16847698ENST00000357277+1418328_339526.0661.0Calcium bindingOntology_term=ECO:0000255
HgeneREPS2chrX:17121902chrX:16847699ENST00000303843+1418328_339525.0660.0Calcium bindingOntology_term=ECO:0000255
HgeneREPS2chrX:17121902chrX:16847699ENST00000357277+1418328_339526.0661.0Calcium bindingOntology_term=ECO:0000255
HgeneREPS2chrX:17152030chrX:16852406ENST00000303843+1518328_339553.0660.0Calcium bindingOntology_term=ECO:0000255
HgeneREPS2chrX:17152030chrX:16852406ENST00000357277+1518328_339554.0661.0Calcium bindingOntology_term=ECO:0000255
HgeneREPS2chrX:16965257chrX:16836697ENST00000303843+1183_7691.0660.0Compositional biasNote=Ala-rich
HgeneREPS2chrX:16965257chrX:16836697ENST00000357277+1183_7691.0661.0Compositional biasNote=Ala-rich
HgeneREPS2chrX:17047746chrX:16859551ENST00000303843+5183_76256.0660.0Compositional biasNote=Ala-rich
HgeneREPS2chrX:17047746chrX:16859551ENST00000357277+5183_76257.0661.0Compositional biasNote=Ala-rich
HgeneREPS2chrX:17121902chrX:16836697ENST00000303843+14183_76525.0660.0Compositional biasNote=Ala-rich
HgeneREPS2chrX:17121902chrX:16836697ENST00000303843+1418477_524525.0660.0Compositional biasNote=Pro-rich
HgeneREPS2chrX:17121902chrX:16836697ENST00000357277+14183_76526.0661.0Compositional biasNote=Ala-rich
HgeneREPS2chrX:17121902chrX:16836697ENST00000357277+1418477_524526.0661.0Compositional biasNote=Pro-rich
HgeneREPS2chrX:17121902chrX:16847698ENST00000303843+14183_76525.0660.0Compositional biasNote=Ala-rich
HgeneREPS2chrX:17121902chrX:16847698ENST00000303843+1418477_524525.0660.0Compositional biasNote=Pro-rich
HgeneREPS2chrX:17121902chrX:16847698ENST00000357277+14183_76526.0661.0Compositional biasNote=Ala-rich
HgeneREPS2chrX:17121902chrX:16847698ENST00000357277+1418477_524526.0661.0Compositional biasNote=Pro-rich
HgeneREPS2chrX:17121902chrX:16847699ENST00000303843+14183_76525.0660.0Compositional biasNote=Ala-rich
HgeneREPS2chrX:17121902chrX:16847699ENST00000303843+1418477_524525.0660.0Compositional biasNote=Pro-rich
HgeneREPS2chrX:17121902chrX:16847699ENST00000357277+14183_76526.0661.0Compositional biasNote=Ala-rich
HgeneREPS2chrX:17121902chrX:16847699ENST00000357277+1418477_524526.0661.0Compositional biasNote=Pro-rich
HgeneREPS2chrX:17152030chrX:16852406ENST00000303843+15183_76553.0660.0Compositional biasNote=Ala-rich
HgeneREPS2chrX:17152030chrX:16852406ENST00000303843+1518477_524553.0660.0Compositional biasNote=Pro-rich
HgeneREPS2chrX:17152030chrX:16852406ENST00000357277+15183_76554.0661.0Compositional biasNote=Ala-rich
HgeneREPS2chrX:17152030chrX:16852406ENST00000357277+1518477_524554.0661.0Compositional biasNote=Pro-rich
HgeneREPS2chrX:17047746chrX:16859551ENST00000303843+51834_147256.0660.0DomainEH 1
HgeneREPS2chrX:17047746chrX:16859551ENST00000357277+51834_147257.0661.0DomainEH 1
HgeneREPS2chrX:17121902chrX:16836697ENST00000303843+1418282_373525.0660.0DomainEH 2
HgeneREPS2chrX:17121902chrX:16836697ENST00000303843+1418315_350525.0660.0DomainEF-hand
HgeneREPS2chrX:17121902chrX:16836697ENST00000303843+141834_147525.0660.0DomainEH 1
HgeneREPS2chrX:17121902chrX:16836697ENST00000357277+1418282_373526.0661.0DomainEH 2
HgeneREPS2chrX:17121902chrX:16836697ENST00000357277+1418315_350526.0661.0DomainEF-hand
HgeneREPS2chrX:17121902chrX:16836697ENST00000357277+141834_147526.0661.0DomainEH 1
HgeneREPS2chrX:17121902chrX:16847698ENST00000303843+1418282_373525.0660.0DomainEH 2
HgeneREPS2chrX:17121902chrX:16847698ENST00000303843+1418315_350525.0660.0DomainEF-hand
HgeneREPS2chrX:17121902chrX:16847698ENST00000303843+141834_147525.0660.0DomainEH 1
HgeneREPS2chrX:17121902chrX:16847698ENST00000357277+1418282_373526.0661.0DomainEH 2
HgeneREPS2chrX:17121902chrX:16847698ENST00000357277+1418315_350526.0661.0DomainEF-hand
HgeneREPS2chrX:17121902chrX:16847698ENST00000357277+141834_147526.0661.0DomainEH 1
HgeneREPS2chrX:17121902chrX:16847699ENST00000303843+1418282_373525.0660.0DomainEH 2
HgeneREPS2chrX:17121902chrX:16847699ENST00000303843+1418315_350525.0660.0DomainEF-hand
HgeneREPS2chrX:17121902chrX:16847699ENST00000303843+141834_147525.0660.0DomainEH 1
HgeneREPS2chrX:17121902chrX:16847699ENST00000357277+1418282_373526.0661.0DomainEH 2
HgeneREPS2chrX:17121902chrX:16847699ENST00000357277+1418315_350526.0661.0DomainEF-hand
HgeneREPS2chrX:17121902chrX:16847699ENST00000357277+141834_147526.0661.0DomainEH 1
HgeneREPS2chrX:17152030chrX:16852406ENST00000303843+1518282_373553.0660.0DomainEH 2
HgeneREPS2chrX:17152030chrX:16852406ENST00000303843+1518315_350553.0660.0DomainEF-hand
HgeneREPS2chrX:17152030chrX:16852406ENST00000303843+151834_147553.0660.0DomainEH 1
HgeneREPS2chrX:17152030chrX:16852406ENST00000357277+1518282_373554.0661.0DomainEH 2
HgeneREPS2chrX:17152030chrX:16852406ENST00000357277+1518315_350554.0661.0DomainEF-hand
HgeneREPS2chrX:17152030chrX:16852406ENST00000357277+151834_147554.0661.0DomainEH 1
TgeneTXLNGchrX:16965257chrX:16836697ENST00000380122010153_46434.0529.0Coiled coilOntology_term=ECO:0000255
TgeneTXLNGchrX:16965257chrX:16836697ENST0000039815508153_4640397.0Coiled coilOntology_term=ECO:0000255
TgeneTXLNGchrX:17121902chrX:16836697ENST00000380122010153_46434.0529.0Coiled coilOntology_term=ECO:0000255
TgeneTXLNGchrX:17121902chrX:16836697ENST0000039815508153_4640397.0Coiled coilOntology_term=ECO:0000255
TgeneTXLNGchrX:17121902chrX:16847698ENST0000039815518153_46491.0397.0Coiled coilOntology_term=ECO:0000255
TgeneTXLNGchrX:17121902chrX:16847699ENST0000039815518153_46491.0397.0Coiled coilOntology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneREPS2chrX:16965257chrX:16836697ENST00000303843+118328_33991.0660.0Calcium bindingOntology_term=ECO:0000255
HgeneREPS2chrX:16965257chrX:16836697ENST00000357277+118328_33991.0661.0Calcium bindingOntology_term=ECO:0000255
HgeneREPS2chrX:17047746chrX:16859551ENST00000303843+518328_339256.0660.0Calcium bindingOntology_term=ECO:0000255
HgeneREPS2chrX:17047746chrX:16859551ENST00000357277+518328_339257.0661.0Calcium bindingOntology_term=ECO:0000255
HgeneREPS2chrX:16965257chrX:16836697ENST00000303843+118601_65791.0660.0Coiled coilOntology_term=ECO:0000255
HgeneREPS2chrX:16965257chrX:16836697ENST00000357277+118601_65791.0661.0Coiled coilOntology_term=ECO:0000255
HgeneREPS2chrX:17047746chrX:16859551ENST00000303843+518601_657256.0660.0Coiled coilOntology_term=ECO:0000255
HgeneREPS2chrX:17047746chrX:16859551ENST00000357277+518601_657257.0661.0Coiled coilOntology_term=ECO:0000255
HgeneREPS2chrX:17121902chrX:16836697ENST00000303843+1418601_657525.0660.0Coiled coilOntology_term=ECO:0000255
HgeneREPS2chrX:17121902chrX:16836697ENST00000357277+1418601_657526.0661.0Coiled coilOntology_term=ECO:0000255
HgeneREPS2chrX:17121902chrX:16847698ENST00000303843+1418601_657525.0660.0Coiled coilOntology_term=ECO:0000255
HgeneREPS2chrX:17121902chrX:16847698ENST00000357277+1418601_657526.0661.0Coiled coilOntology_term=ECO:0000255
HgeneREPS2chrX:17121902chrX:16847699ENST00000303843+1418601_657525.0660.0Coiled coilOntology_term=ECO:0000255
HgeneREPS2chrX:17121902chrX:16847699ENST00000357277+1418601_657526.0661.0Coiled coilOntology_term=ECO:0000255
HgeneREPS2chrX:17152030chrX:16852406ENST00000303843+1518601_657553.0660.0Coiled coilOntology_term=ECO:0000255
HgeneREPS2chrX:17152030chrX:16852406ENST00000357277+1518601_657554.0661.0Coiled coilOntology_term=ECO:0000255
HgeneREPS2chrX:16965257chrX:16836697ENST00000303843+118477_52491.0660.0Compositional biasNote=Pro-rich
HgeneREPS2chrX:16965257chrX:16836697ENST00000357277+118477_52491.0661.0Compositional biasNote=Pro-rich
HgeneREPS2chrX:17047746chrX:16859551ENST00000303843+518477_524256.0660.0Compositional biasNote=Pro-rich
HgeneREPS2chrX:17047746chrX:16859551ENST00000357277+518477_524257.0661.0Compositional biasNote=Pro-rich
HgeneREPS2chrX:16965257chrX:16836697ENST00000303843+118282_37391.0660.0DomainEH 2
HgeneREPS2chrX:16965257chrX:16836697ENST00000303843+118315_35091.0660.0DomainEF-hand
HgeneREPS2chrX:16965257chrX:16836697ENST00000303843+11834_14791.0660.0DomainEH 1
HgeneREPS2chrX:16965257chrX:16836697ENST00000357277+118282_37391.0661.0DomainEH 2
HgeneREPS2chrX:16965257chrX:16836697ENST00000357277+118315_35091.0661.0DomainEF-hand
HgeneREPS2chrX:16965257chrX:16836697ENST00000357277+11834_14791.0661.0DomainEH 1
HgeneREPS2chrX:17047746chrX:16859551ENST00000303843+518282_373256.0660.0DomainEH 2
HgeneREPS2chrX:17047746chrX:16859551ENST00000303843+518315_350256.0660.0DomainEF-hand
HgeneREPS2chrX:17047746chrX:16859551ENST00000357277+518282_373257.0661.0DomainEH 2
HgeneREPS2chrX:17047746chrX:16859551ENST00000357277+518315_350257.0661.0DomainEF-hand
TgeneTXLNGchrX:17047746chrX:16859551ENST00000380122810153_464416.0529.0Coiled coilOntology_term=ECO:0000255
TgeneTXLNGchrX:17047746chrX:16859551ENST0000039815568153_464284.0397.0Coiled coilOntology_term=ECO:0000255
TgeneTXLNGchrX:17121902chrX:16847698ENST00000380122310153_464223.0529.0Coiled coilOntology_term=ECO:0000255
TgeneTXLNGchrX:17121902chrX:16847699ENST00000380122310153_464223.0529.0Coiled coilOntology_term=ECO:0000255
TgeneTXLNGchrX:17152030chrX:16852406ENST00000380122510153_464328.0529.0Coiled coilOntology_term=ECO:0000255
TgeneTXLNGchrX:17152030chrX:16852406ENST0000039815538153_464196.0397.0Coiled coilOntology_term=ECO:0000255


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1518_REPS2_17152030_TXLNG_16852406_ranked_0.pdbREPS21696525717152030ENST00000380122TXLNGchrX16852406+
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLH
QITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSS
YPDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGL
PPTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDS
NSLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQSEQVSEAELLPQLS
RAPSQAAESSPAKKLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIIWRTKWE
NNNKALLQMAEEKTVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTALDSHKELNTSSK
754


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
REPS2_pLDDT.png
all structure
all structure
TXLNG_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
REPS2
TXLNG


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneREPS2chrX:16965257chrX:16836697ENST00000303843+118561_66091.0660.0ASAP1
HgeneREPS2chrX:16965257chrX:16836697ENST00000357277+118561_66091.0661.0ASAP1
HgeneREPS2chrX:17047746chrX:16859551ENST00000303843+518561_660256.0660.0ASAP1
HgeneREPS2chrX:17047746chrX:16859551ENST00000357277+518561_660257.0661.0ASAP1
HgeneREPS2chrX:17121902chrX:16836697ENST00000303843+1418561_660525.0660.0ASAP1
HgeneREPS2chrX:17121902chrX:16836697ENST00000357277+1418561_660526.0661.0ASAP1
HgeneREPS2chrX:17121902chrX:16847698ENST00000303843+1418561_660525.0660.0ASAP1
HgeneREPS2chrX:17121902chrX:16847698ENST00000357277+1418561_660526.0661.0ASAP1
HgeneREPS2chrX:17121902chrX:16847699ENST00000303843+1418561_660525.0660.0ASAP1
HgeneREPS2chrX:17121902chrX:16847699ENST00000357277+1418561_660526.0661.0ASAP1
HgeneREPS2chrX:17152030chrX:16852406ENST00000303843+1518561_660553.0660.0ASAP1
HgeneREPS2chrX:17152030chrX:16852406ENST00000357277+1518561_660554.0661.0ASAP1
HgeneREPS2chrX:16965257chrX:16836697ENST00000303843+118514_66091.0660.0RALBP1
HgeneREPS2chrX:16965257chrX:16836697ENST00000357277+118514_66091.0661.0RALBP1
HgeneREPS2chrX:17047746chrX:16859551ENST00000303843+518514_660256.0660.0RALBP1
HgeneREPS2chrX:17047746chrX:16859551ENST00000357277+518514_660257.0661.0RALBP1
HgeneREPS2chrX:17121902chrX:16836697ENST00000303843+1418514_660525.0660.0RALBP1
HgeneREPS2chrX:17121902chrX:16836697ENST00000357277+1418514_660526.0661.0RALBP1
HgeneREPS2chrX:17121902chrX:16847698ENST00000303843+1418514_660525.0660.0RALBP1
HgeneREPS2chrX:17121902chrX:16847698ENST00000357277+1418514_660526.0661.0RALBP1
HgeneREPS2chrX:17121902chrX:16847699ENST00000303843+1418514_660525.0660.0RALBP1
HgeneREPS2chrX:17121902chrX:16847699ENST00000357277+1418514_660526.0661.0RALBP1
HgeneREPS2chrX:17152030chrX:16852406ENST00000303843+1518514_660553.0660.0RALBP1
HgeneREPS2chrX:17152030chrX:16852406ENST00000357277+1518514_660554.0661.0RALBP1


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Related Drugs to REPS2-TXLNG


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to REPS2-TXLNG


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource