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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:RERE-GPR157

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RERE-GPR157
FusionPDB ID: 73499
FusionGDB2.0 ID: 73499
HgeneTgene
Gene symbol

RERE

GPR157

Gene ID

473

80045

Gene namearginine-glutamic acid dipeptide repeatsG protein-coupled receptor 157
SynonymsARG|ARP|ATN1L|DNB1|NEDBEH-
Cytomap

1p36.23

1p36.22

Type of geneprotein-codingprotein-coding
Descriptionarginine-glutamic acid dipeptide repeats proteinarginine-glutamic acid dipeptide (RE) repeatsatrophin 2atrophin-1 like proteinatrophin-1 related proteinG-protein coupled receptor 157probable G-protein coupled receptor 157
Modification date2020031320200313
UniProtAcc.

Q5UAW9

Ensembl transtripts involved in fusion geneENST idsENST00000460659, ENST00000476556, 
ENST00000337907, ENST00000377464, 
ENST00000400907, ENST00000400908, 
ENST00000377411, ENST00000414642, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score27 X 28 X 11=83162 X 2 X 3=12
# samples 434
** MAII scorelog2(43/8316*10)=-4.27348119326891
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RERE [Title/Abstract] AND GPR157 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RERE(8716032)-GPR157(9171548), # samples:2
RERE(8482787)-GPR157(9171548), # samples:2
Anticipated loss of major functional domain due to fusion event.RERE-GPR157 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RERE-GPR157 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RERE-GPR157 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RERE-GPR157 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RERE-GPR157 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RERE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GPR157 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A140-01AREREchr1

8716032

-GPR157chr1

9171548

-
ChimerDB4LUADTCGA-55-7574-01AREREchr1

8482787

-GPR157chr1

9171548

-
ChimerDB4LUADTCGA-55-7574REREchr1

8482786

-GPR157chr1

9171548

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000400908REREchr18716032-ENST00000377411GPR157chr19171548-56929531658939239
ENST00000400908REREchr18716032-ENST00000414642GPR157chr19171548-14719531463939174

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000400908ENST00000377411REREchr18716032-GPR157chr19171548-0.67238280.3276172
ENST00000400908ENST00000414642REREchr18716032-GPR157chr19171548-0.0220659170.97793406

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>73499_73499_1_RERE-GPR157_RERE_chr1_8716032_ENST00000400908_GPR157_chr1_9171548_ENST00000377411_length(amino acids)=239AA_BP=1
MPLQQGLTEVPTPRKAAPMHRTRKDKSSGAWKFPWGPLGFLRFSWLGRRGSLGSASRALGGRLRRAAAATEREEPSSDGAGAEDEHDAVG
TSLKRVPDTMQNHQHRRLHGRGATEGQHEPHGAPDPEADEDERDEHQLLVRHGGVAQQAVLLGEDGPVLRECRVRSVDVLPDQEVQQRQQ

--------------------------------------------------------------

>73499_73499_2_RERE-GPR157_RERE_chr1_8716032_ENST00000400908_GPR157_chr1_9171548_ENST00000414642_length(amino acids)=174AA_BP=1
MPLQQGLTEVPTPRKAAPMHRTRKDKSSGAWKFPWGPLGFLRFSWLGRRGSLGSASRALGGRLRRAAAATEREEPSSDGAGAEDEHDAVG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:8716032/chr1:9171548)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GPR157

Q5UAW9

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger. {ECO:0000250|UniProtKB:Q8C206}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGPR157chr1:8716032chr1:9171548ENST0000037741104294_298127.66666666666667336.0Compositional biasNote=Poly-Cys
TgeneGPR157chr1:8716032chr1:9171548ENST0000037741104141_166127.66666666666667336.0Topological domainExtracellular
TgeneGPR157chr1:8716032chr1:9171548ENST0000037741104188_226127.66666666666667336.0Topological domainCytoplasmic
TgeneGPR157chr1:8716032chr1:9171548ENST0000037741104248_258127.66666666666667336.0Topological domainExtracellular
TgeneGPR157chr1:8716032chr1:9171548ENST0000037741104280_335127.66666666666667336.0Topological domainCytoplasmic
TgeneGPR157chr1:8716032chr1:9171548ENST0000037741104167_187127.66666666666667336.0TransmembraneHelical%3B Name%3D5
TgeneGPR157chr1:8716032chr1:9171548ENST0000037741104227_247127.66666666666667336.0TransmembraneHelical%3B Name%3D6
TgeneGPR157chr1:8716032chr1:9171548ENST0000037741104259_279127.66666666666667336.0TransmembraneHelical%3B Name%3D7

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneREREchr1:8716032chr1:9171548ENST00000337907-3241156_1211108.333333333333331567.0Coiled coilOntology_term=ECO:0000255
HgeneREREchr1:8716032chr1:9171548ENST00000400908-2231156_1211108.333333333333331567.0Coiled coilOntology_term=ECO:0000255
HgeneREREchr1:8716032chr1:9171548ENST00000476556-1131156_121101013.0Coiled coilOntology_term=ECO:0000255
HgeneREREchr1:8716032chr1:9171548ENST00000337907-3241179_1204108.333333333333331567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8716032chr1:9171548ENST00000337907-3241300_1322108.333333333333331567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8716032chr1:9171548ENST00000337907-3241425_1445108.333333333333331567.0Compositional biasNote=His-rich
HgeneREREchr1:8716032chr1:9171548ENST00000337907-3241451_1510108.333333333333331567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8716032chr1:9171548ENST00000337907-324738_1118108.333333333333331567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8716032chr1:9171548ENST00000400908-2231179_1204108.333333333333331567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8716032chr1:9171548ENST00000400908-2231300_1322108.333333333333331567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8716032chr1:9171548ENST00000400908-2231425_1445108.333333333333331567.0Compositional biasNote=His-rich
HgeneREREchr1:8716032chr1:9171548ENST00000400908-2231451_1510108.333333333333331567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8716032chr1:9171548ENST00000400908-223738_1118108.333333333333331567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8716032chr1:9171548ENST00000476556-1131179_120401013.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8716032chr1:9171548ENST00000476556-1131300_132201013.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8716032chr1:9171548ENST00000476556-1131425_144501013.0Compositional biasNote=His-rich
HgeneREREchr1:8716032chr1:9171548ENST00000476556-1131451_151001013.0Compositional biasNote=Pro-rich
HgeneREREchr1:8716032chr1:9171548ENST00000476556-113738_111801013.0Compositional biasNote=Pro-rich
HgeneREREchr1:8716032chr1:9171548ENST00000337907-324103_283108.333333333333331567.0DomainBAH
HgeneREREchr1:8716032chr1:9171548ENST00000337907-324284_387108.333333333333331567.0DomainELM2
HgeneREREchr1:8716032chr1:9171548ENST00000337907-324391_443108.333333333333331567.0DomainSANT
HgeneREREchr1:8716032chr1:9171548ENST00000400908-223103_283108.333333333333331567.0DomainBAH
HgeneREREchr1:8716032chr1:9171548ENST00000400908-223284_387108.333333333333331567.0DomainELM2
HgeneREREchr1:8716032chr1:9171548ENST00000400908-223391_443108.333333333333331567.0DomainSANT
HgeneREREchr1:8716032chr1:9171548ENST00000476556-113103_28301013.0DomainBAH
HgeneREREchr1:8716032chr1:9171548ENST00000476556-113284_38701013.0DomainELM2
HgeneREREchr1:8716032chr1:9171548ENST00000476556-113391_44301013.0DomainSANT
HgeneREREchr1:8716032chr1:9171548ENST00000337907-324507_532108.333333333333331567.0Zinc fingerNote=GATA-type
HgeneREREchr1:8716032chr1:9171548ENST00000400908-223507_532108.333333333333331567.0Zinc fingerNote=GATA-type
HgeneREREchr1:8716032chr1:9171548ENST00000476556-113507_53201013.0Zinc fingerNote=GATA-type
TgeneGPR157chr1:8716032chr1:9171548ENST0000037741104109_119127.66666666666667336.0Topological domainCytoplasmic
TgeneGPR157chr1:8716032chr1:9171548ENST00000377411041_15127.66666666666667336.0Topological domainExtracellular
TgeneGPR157chr1:8716032chr1:9171548ENST000003774110437_48127.66666666666667336.0Topological domainCytoplasmic
TgeneGPR157chr1:8716032chr1:9171548ENST000003774110470_87127.66666666666667336.0Topological domainExtracellular
TgeneGPR157chr1:8716032chr1:9171548ENST0000037741104120_140127.66666666666667336.0TransmembraneHelical%3B Name%3D4
TgeneGPR157chr1:8716032chr1:9171548ENST000003774110416_36127.66666666666667336.0TransmembraneHelical%3B Name%3D1
TgeneGPR157chr1:8716032chr1:9171548ENST000003774110449_69127.66666666666667336.0TransmembraneHelical%3B Name%3D2
TgeneGPR157chr1:8716032chr1:9171548ENST000003774110488_108127.66666666666667336.0TransmembraneHelical%3B Name%3D3


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RERE
GPR157


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to RERE-GPR157


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RERE-GPR157


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource