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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:RERE-TPM3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RERE-TPM3
FusionPDB ID: 73534
FusionGDB2.0 ID: 73534
HgeneTgene
Gene symbol

RERE

TPM3

Gene ID

473

7170

Gene namearginine-glutamic acid dipeptide repeatstropomyosin 3
SynonymsARG|ARP|ATN1L|DNB1|NEDBEHCAPM1|CFTD|HEL-189|HEL-S-82p|NEM1|OK/SW-cl.5|TM-5|TM3|TM30|TM30nm|TM5|TPM3nu|TPMsk3|TRK|hscp30
Cytomap

1p36.23

1q21.3

Type of geneprotein-codingprotein-coding
Descriptionarginine-glutamic acid dipeptide repeats proteinarginine-glutamic acid dipeptide (RE) repeatsatrophin 2atrophin-1 like proteinatrophin-1 related proteintropomyosin alpha-3 chainalpha-tropomyosin, slow skeletalcytoskeletal tropomyosin TM30epididymis luminal protein 189epididymis secretory sperm binding protein Li 82pheat-stable cytoskeletal protein 30 kDatropomyosin 3 nutropomyosin gammatropomyosi
Modification date2020031320200328
UniProtAcc.

P06753

Ensembl transtripts involved in fusion geneENST idsENST00000337907, ENST00000400907, 
ENST00000400908, ENST00000377464, 
ENST00000460659, ENST00000476556, 
ENST00000302206, ENST00000323144, 
ENST00000368530, ENST00000368531, 
ENST00000271850, ENST00000328159, 
ENST00000330188, ENST00000341372, 
ENST00000341485, ENST00000469717, 
ENST00000368533, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score27 X 28 X 11=83169 X 10 X 5=450
# samples 4312
** MAII scorelog2(43/8316*10)=-4.27348119326891
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/450*10)=-1.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RERE [Title/Abstract] AND TPM3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RERE(8674620)-TPM3(154148724), # samples:3
Anticipated loss of major functional domain due to fusion event.RERE-TPM3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RERE-TPM3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RERE-TPM3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RERE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TPM3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-RD-A8MW-01AREREchr1

8674620

-TPM3chr1

154148724

-
ChimerDB4STADTCGA-RD-A8MW-01AREREchr1

8684369

-TPM3chr1

154148724

-
ChimerDB4STADTCGA-RD-A8MWREREchr1

8674619

-TPM3chr1

154148724

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000337907REREchr18674620-ENST00000368533TPM3chr1154148724-410311575331771412
ENST00000400907REREchr18674620-ENST00000368533TPM3chr1154148724-3542596741210378
ENST00000337907REREchr18674619-ENST00000368533TPM3chr1154148724-410311575331771412
ENST00000400907REREchr18674619-ENST00000368533TPM3chr1154148724-3542596741210378
ENST00000337907REREchr18684369-ENST00000368533TPM3chr1154148724-397710315331645370
ENST00000400907REREchr18684369-ENST00000368533TPM3chr1154148724-3416470741084336

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000337907ENST00000368533REREchr18674620-TPM3chr1154148724-0.0005977570.9994023
ENST00000400907ENST00000368533REREchr18674620-TPM3chr1154148724-0.0005500250.99945
ENST00000337907ENST00000368533REREchr18674619-TPM3chr1154148724-0.0005977570.9994023
ENST00000400907ENST00000368533REREchr18674619-TPM3chr1154148724-0.0005500250.99945
ENST00000337907ENST00000368533REREchr18684369-TPM3chr1154148724-0.0004112420.9995888
ENST00000400907ENST00000368533REREchr18684369-TPM3chr1154148724-0.0003780670.99962187

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>73534_73534_1_RERE-TPM3_RERE_chr1_8674619_ENST00000337907_TPM3_chr1_154148724_ENST00000368533_length(amino acids)=412AA_BP=201
MELSEKFRRLKPRLTVYLSRRPSRERTEEGTWRIMTADKDKDKDKEKDRDRDRDREREKRDKARESENSRPRRSCTLEGGAKNYAESDHS
EDEDNDNNSATAEESTKKNKKKPPKKKSRYERTDTGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHNSQACCRSPTPA
LCDPPACSLPVASQPPQHLSEAGRGPVGAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKME
LQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKL

--------------------------------------------------------------

>73534_73534_2_RERE-TPM3_RERE_chr1_8674619_ENST00000400907_TPM3_chr1_154148724_ENST00000368533_length(amino acids)=378AA_BP=167
MTADKDKDKDKEKDRDRDRDREREKRDKARESENSRPRRSCTLEGGAKNYAESDHSEDEDNDNNSATAEESTKKNKKKPPKKKSRYERTD
TGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHNSQACCRSPTPALCDPPACSLPVASQPPQHLSEAGRGPVGAEAEVA
SLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDL
ERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE

--------------------------------------------------------------

>73534_73534_3_RERE-TPM3_RERE_chr1_8674620_ENST00000337907_TPM3_chr1_154148724_ENST00000368533_length(amino acids)=412AA_BP=201
MELSEKFRRLKPRLTVYLSRRPSRERTEEGTWRIMTADKDKDKDKEKDRDRDRDREREKRDKARESENSRPRRSCTLEGGAKNYAESDHS
EDEDNDNNSATAEESTKKNKKKPPKKKSRYERTDTGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHNSQACCRSPTPA
LCDPPACSLPVASQPPQHLSEAGRGPVGAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKME
LQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKL

--------------------------------------------------------------

>73534_73534_4_RERE-TPM3_RERE_chr1_8674620_ENST00000400907_TPM3_chr1_154148724_ENST00000368533_length(amino acids)=378AA_BP=167
MTADKDKDKDKEKDRDRDRDREREKRDKARESENSRPRRSCTLEGGAKNYAESDHSEDEDNDNNSATAEESTKKNKKKPPKKKSRYERTD
TGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHNSQACCRSPTPALCDPPACSLPVASQPPQHLSEAGRGPVGAEAEVA
SLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDL
ERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE

--------------------------------------------------------------

>73534_73534_5_RERE-TPM3_RERE_chr1_8684369_ENST00000337907_TPM3_chr1_154148724_ENST00000368533_length(amino acids)=370AA_BP=166
MELSEKFRRLKPRLTVYLSRRPSRERTEEGTWRIMTADKDKDKDKEKDRDRDRDREREKRDKARESENSRPRRSCTLEGGAKNYAESDHS
EDEDNDNNSATAEESTKKNKKKPPKKKSRYERTDTGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLAEAEVASLNRRIQL
VEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAE
LAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRML

--------------------------------------------------------------

>73534_73534_6_RERE-TPM3_RERE_chr1_8684369_ENST00000400907_TPM3_chr1_154148724_ENST00000368533_length(amino acids)=336AA_BP=132
MTADKDKDKDKEKDRDRDRDREREKRDKARESENSRPRRSCTLEGGAKNYAESDHSEDEDNDNNSATAEESTKKNKKKPPKKKSRYERTD
TGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMK
VIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:8674620/chr1:154148724)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TPM3

P06753

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. {ECO:0000250|UniProtKB:P09493}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneREREchr1:8674619chr1:154148724ENST00000337907-5241156_1211174.01567.0Coiled coilOntology_term=ECO:0000255
HgeneREREchr1:8674619chr1:154148724ENST00000400908-4231156_1211174.01567.0Coiled coilOntology_term=ECO:0000255
HgeneREREchr1:8674619chr1:154148724ENST00000476556-1131156_121101013.0Coiled coilOntology_term=ECO:0000255
HgeneREREchr1:8674620chr1:154148724ENST00000337907-5241156_1211174.01567.0Coiled coilOntology_term=ECO:0000255
HgeneREREchr1:8674620chr1:154148724ENST00000400908-4231156_1211174.01567.0Coiled coilOntology_term=ECO:0000255
HgeneREREchr1:8674620chr1:154148724ENST00000476556-1131156_121101013.0Coiled coilOntology_term=ECO:0000255
HgeneREREchr1:8684369chr1:154148724ENST00000337907-4241156_1211132.01567.0Coiled coilOntology_term=ECO:0000255
HgeneREREchr1:8684369chr1:154148724ENST00000400908-3231156_1211132.01567.0Coiled coilOntology_term=ECO:0000255
HgeneREREchr1:8684369chr1:154148724ENST00000476556-1131156_121101013.0Coiled coilOntology_term=ECO:0000255
HgeneREREchr1:8674619chr1:154148724ENST00000337907-5241179_1204174.01567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8674619chr1:154148724ENST00000337907-5241300_1322174.01567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8674619chr1:154148724ENST00000337907-5241425_1445174.01567.0Compositional biasNote=His-rich
HgeneREREchr1:8674619chr1:154148724ENST00000337907-5241451_1510174.01567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8674619chr1:154148724ENST00000337907-524738_1118174.01567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8674619chr1:154148724ENST00000400908-4231179_1204174.01567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8674619chr1:154148724ENST00000400908-4231300_1322174.01567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8674619chr1:154148724ENST00000400908-4231425_1445174.01567.0Compositional biasNote=His-rich
HgeneREREchr1:8674619chr1:154148724ENST00000400908-4231451_1510174.01567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8674619chr1:154148724ENST00000400908-423738_1118174.01567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8674619chr1:154148724ENST00000476556-1131179_120401013.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8674619chr1:154148724ENST00000476556-1131300_132201013.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8674619chr1:154148724ENST00000476556-1131425_144501013.0Compositional biasNote=His-rich
HgeneREREchr1:8674619chr1:154148724ENST00000476556-1131451_151001013.0Compositional biasNote=Pro-rich
HgeneREREchr1:8674619chr1:154148724ENST00000476556-113738_111801013.0Compositional biasNote=Pro-rich
HgeneREREchr1:8674620chr1:154148724ENST00000337907-5241179_1204174.01567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8674620chr1:154148724ENST00000337907-5241300_1322174.01567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8674620chr1:154148724ENST00000337907-5241425_1445174.01567.0Compositional biasNote=His-rich
HgeneREREchr1:8674620chr1:154148724ENST00000337907-5241451_1510174.01567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8674620chr1:154148724ENST00000337907-524738_1118174.01567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8674620chr1:154148724ENST00000400908-4231179_1204174.01567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8674620chr1:154148724ENST00000400908-4231300_1322174.01567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8674620chr1:154148724ENST00000400908-4231425_1445174.01567.0Compositional biasNote=His-rich
HgeneREREchr1:8674620chr1:154148724ENST00000400908-4231451_1510174.01567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8674620chr1:154148724ENST00000400908-423738_1118174.01567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8674620chr1:154148724ENST00000476556-1131179_120401013.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8674620chr1:154148724ENST00000476556-1131300_132201013.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8674620chr1:154148724ENST00000476556-1131425_144501013.0Compositional biasNote=His-rich
HgeneREREchr1:8674620chr1:154148724ENST00000476556-1131451_151001013.0Compositional biasNote=Pro-rich
HgeneREREchr1:8674620chr1:154148724ENST00000476556-113738_111801013.0Compositional biasNote=Pro-rich
HgeneREREchr1:8684369chr1:154148724ENST00000337907-4241179_1204132.01567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8684369chr1:154148724ENST00000337907-4241300_1322132.01567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8684369chr1:154148724ENST00000337907-4241425_1445132.01567.0Compositional biasNote=His-rich
HgeneREREchr1:8684369chr1:154148724ENST00000337907-4241451_1510132.01567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8684369chr1:154148724ENST00000337907-424738_1118132.01567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8684369chr1:154148724ENST00000400908-3231179_1204132.01567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8684369chr1:154148724ENST00000400908-3231300_1322132.01567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8684369chr1:154148724ENST00000400908-3231425_1445132.01567.0Compositional biasNote=His-rich
HgeneREREchr1:8684369chr1:154148724ENST00000400908-3231451_1510132.01567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8684369chr1:154148724ENST00000400908-323738_1118132.01567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8684369chr1:154148724ENST00000476556-1131179_120401013.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8684369chr1:154148724ENST00000476556-1131300_132201013.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8684369chr1:154148724ENST00000476556-1131425_144501013.0Compositional biasNote=His-rich
HgeneREREchr1:8684369chr1:154148724ENST00000476556-1131451_151001013.0Compositional biasNote=Pro-rich
HgeneREREchr1:8684369chr1:154148724ENST00000476556-113738_111801013.0Compositional biasNote=Pro-rich
HgeneREREchr1:8674619chr1:154148724ENST00000337907-524103_283174.01567.0DomainBAH
HgeneREREchr1:8674619chr1:154148724ENST00000337907-524284_387174.01567.0DomainELM2
HgeneREREchr1:8674619chr1:154148724ENST00000337907-524391_443174.01567.0DomainSANT
HgeneREREchr1:8674619chr1:154148724ENST00000400908-423103_283174.01567.0DomainBAH
HgeneREREchr1:8674619chr1:154148724ENST00000400908-423284_387174.01567.0DomainELM2
HgeneREREchr1:8674619chr1:154148724ENST00000400908-423391_443174.01567.0DomainSANT
HgeneREREchr1:8674619chr1:154148724ENST00000476556-113103_28301013.0DomainBAH
HgeneREREchr1:8674619chr1:154148724ENST00000476556-113284_38701013.0DomainELM2
HgeneREREchr1:8674619chr1:154148724ENST00000476556-113391_44301013.0DomainSANT
HgeneREREchr1:8674620chr1:154148724ENST00000337907-524103_283174.01567.0DomainBAH
HgeneREREchr1:8674620chr1:154148724ENST00000337907-524284_387174.01567.0DomainELM2
HgeneREREchr1:8674620chr1:154148724ENST00000337907-524391_443174.01567.0DomainSANT
HgeneREREchr1:8674620chr1:154148724ENST00000400908-423103_283174.01567.0DomainBAH
HgeneREREchr1:8674620chr1:154148724ENST00000400908-423284_387174.01567.0DomainELM2
HgeneREREchr1:8674620chr1:154148724ENST00000400908-423391_443174.01567.0DomainSANT
HgeneREREchr1:8674620chr1:154148724ENST00000476556-113103_28301013.0DomainBAH
HgeneREREchr1:8674620chr1:154148724ENST00000476556-113284_38701013.0DomainELM2
HgeneREREchr1:8674620chr1:154148724ENST00000476556-113391_44301013.0DomainSANT
HgeneREREchr1:8684369chr1:154148724ENST00000337907-424103_283132.01567.0DomainBAH
HgeneREREchr1:8684369chr1:154148724ENST00000337907-424284_387132.01567.0DomainELM2
HgeneREREchr1:8684369chr1:154148724ENST00000337907-424391_443132.01567.0DomainSANT
HgeneREREchr1:8684369chr1:154148724ENST00000400908-323103_283132.01567.0DomainBAH
HgeneREREchr1:8684369chr1:154148724ENST00000400908-323284_387132.01567.0DomainELM2
HgeneREREchr1:8684369chr1:154148724ENST00000400908-323391_443132.01567.0DomainSANT
HgeneREREchr1:8684369chr1:154148724ENST00000476556-113103_28301013.0DomainBAH
HgeneREREchr1:8684369chr1:154148724ENST00000476556-113284_38701013.0DomainELM2
HgeneREREchr1:8684369chr1:154148724ENST00000476556-113391_44301013.0DomainSANT
HgeneREREchr1:8674619chr1:154148724ENST00000337907-524507_532174.01567.0Zinc fingerNote=GATA-type
HgeneREREchr1:8674619chr1:154148724ENST00000400908-423507_532174.01567.0Zinc fingerNote=GATA-type
HgeneREREchr1:8674619chr1:154148724ENST00000476556-113507_53201013.0Zinc fingerNote=GATA-type
HgeneREREchr1:8674620chr1:154148724ENST00000337907-524507_532174.01567.0Zinc fingerNote=GATA-type
HgeneREREchr1:8674620chr1:154148724ENST00000400908-423507_532174.01567.0Zinc fingerNote=GATA-type
HgeneREREchr1:8674620chr1:154148724ENST00000476556-113507_53201013.0Zinc fingerNote=GATA-type
HgeneREREchr1:8684369chr1:154148724ENST00000337907-424507_532132.01567.0Zinc fingerNote=GATA-type
HgeneREREchr1:8684369chr1:154148724ENST00000400908-323507_532132.01567.0Zinc fingerNote=GATA-type
HgeneREREchr1:8684369chr1:154148724ENST00000476556-113507_53201013.0Zinc fingerNote=GATA-type
TgeneTPM3chr1:8674619chr1:154148724ENST00000323144081_28544.0248.0Coiled coilOntology_term=ECO:0000250
TgeneTPM3chr1:8674619chr1:154148724ENST00000330188081_28544.0249.0Coiled coilOntology_term=ECO:0000250
TgeneTPM3chr1:8674619chr1:154148724ENST000003685301101_28581.0286.0Coiled coilOntology_term=ECO:0000250
TgeneTPM3chr1:8674619chr1:154148724ENST00000368531081_28544.0248.0Coiled coilOntology_term=ECO:0000250
TgeneTPM3chr1:8674619chr1:154148724ENST00000368533081_28544.0249.0Coiled coilOntology_term=ECO:0000250
TgeneTPM3chr1:8674620chr1:154148724ENST00000323144081_28544.0248.0Coiled coilOntology_term=ECO:0000250
TgeneTPM3chr1:8674620chr1:154148724ENST00000330188081_28544.0249.0Coiled coilOntology_term=ECO:0000250
TgeneTPM3chr1:8674620chr1:154148724ENST000003685301101_28581.0286.0Coiled coilOntology_term=ECO:0000250
TgeneTPM3chr1:8674620chr1:154148724ENST00000368531081_28544.0248.0Coiled coilOntology_term=ECO:0000250
TgeneTPM3chr1:8674620chr1:154148724ENST00000368533081_28544.0249.0Coiled coilOntology_term=ECO:0000250
TgeneTPM3chr1:8684369chr1:154148724ENST00000323144081_28544.0248.0Coiled coilOntology_term=ECO:0000250
TgeneTPM3chr1:8684369chr1:154148724ENST00000330188081_28544.0249.0Coiled coilOntology_term=ECO:0000250
TgeneTPM3chr1:8684369chr1:154148724ENST000003685301101_28581.0286.0Coiled coilOntology_term=ECO:0000250
TgeneTPM3chr1:8684369chr1:154148724ENST00000368531081_28544.0248.0Coiled coilOntology_term=ECO:0000250
TgeneTPM3chr1:8684369chr1:154148724ENST00000368533081_28544.0249.0Coiled coilOntology_term=ECO:0000250


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
TPM3KXD1, TFPT, MCC, EIF4A2, TPM3, TP73, NEK2, RAD21, ELAVL1, SP1, CUL3, CDK2, LRRK2, TPM4, SEC23IP, KYNU, TPM2, TPM1, PRDX1, THOC1, CDC123, SF3A2, SEPT9, HSPB1, BRCA1, MDC1, PAXIP1, HSP90AA1, HSP90AB1, FN1, PAN2, HDAC8, FBXO5, TRAP1, PARK2, FASN, FKBP4, FKBP5, MAGED2, CAP1, MCM3, MGEA5, TP53, HSF2, IFIT3, KCNE1, KIFC3, MAGEA11, PBX3, TRIM27, VPS52, TNNT1, TRIP6, MAD1L1, TLK1, OIP5, BLOC1S6, CCHCR1, THAP1, CCDC146, CCDC102B, CCDC114, SYCE1, IKBIP, C1orf216, LCA5L, FAM9C, HDDC3, WASH3P, LURAP1, SHMT2, MOV10, NXF1, CUL7, OBSL1, RNF2, EGFR, DAPK1, ACTN2, AHCYL1, ATP1A1, CKB, CKMT1B, CKMT1A, COX5A, CYC1, OSTF1, ACTN1, ACTN4, ATP5F1, COX4I1, MTCH1, MYH7B, NDUFB10, PSMA2, PSMA6, STMN1, TBCD, UQCRC2, NTRK1, DVL2, HOOK2, ADD1, CAPZA2, MYH9, PPP1CB, PPP1CC, IQGAP1, PDLIM7, ANLN, MYO5C, MYO19, MYO18A, Actb, Itga5, Myh9, Tpm1, Mis12, Calml3, Myh10, Tpm4, MCM2, RNF20, IMP3, CALCOCO1, JUN, METTL2B, CCDC101, SPAG9, PARK7, PDHA1, VDAC1, TMPO, CTNNB1, LARS, APOE, HDAC4, RXRA, EFTUD2, AAR2, PIH1D1, RPTOR, TNF, FGF11, NOD2, RNF181, AGR2, GPC1, KDM6B, MYC, CDK9, Prkaa1, Prkab1, METTL14, WTAP, ESR2, TET2, DISC1, NR2C2, CSK, AGRN, HOOK3, BMH1, BMH2, VMP1, SNRNP70, BIRC3, ATXN1, TAB2, PSMC5, HSF4, TSKS, NUP54, SNAPIN, TNNI1, PRKCDBP, FGA, PHLDB3, WASH1, THAP7, PLEKHA4, RAD18, PRKD1, SRC, HIST2H2BE, GFM1, MN1, ESR1, MAST2, UNK, DUX4, CIT, AURKB, CHRM3, ECT2, KIF14, KIF20A, SMARCA2, ARHGAP11A, SYDE2, ARHGAP39, Ophn1, MFN2, OPA1, UCHL1, Apc2, FBP1, DTNA, INSIG1, INSIG2, RIN3, TRIM24, PDIA4, SUMO2, MARCKS, CALM1, NEDD4, TKT, CALR, SOD1, FKBP3, TRIM33, RBM8A, PEBP1, PGAM1, CEP78, PTMS, DDX58, CD274, AR, ISG15, UFL1, TMOD1, TRIM37, HTRA4, NAA40, CCDC102A, CCDC6, EXOC4, RBMXL1, TSSC4, KIF5B, EAPP, TPM3P9, PTRF, ZFC3H1, CROCC, NDE1, CCDC96, JUND, ECD, PHF21A, NUF2, NDEL1, HSF1, HOMER2, PRPF8, RCOR1, KDM1A, HOMER1, RCOR3, NES, JUNB, BTF3, TRIM26, FBXW7, DPP4, E, nsp7, ORF7b, ORF8, S, FURIN, nsp4, nsp6, ORF10, CCNF, ANTXR1, FOS, GATA4, KLF10, KLF3, KLF9, ZIC3, NKX2-5, STAT5B,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RERE
TPM3all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to RERE-TPM3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RERE-TPM3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTPM3C1836448Nemaline myopathy 19CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneTPM3C0546264Congenital Fiber Type Disproportion4CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneTPM3C0007097Carcinoma2CTD_human
TgeneTPM3C0024667Animal Mammary Neoplasms2CTD_human
TgeneTPM3C0024668Mammary Neoplasms, Experimental2CTD_human
TgeneTPM3C0205696Anaplastic carcinoma2CTD_human
TgeneTPM3C0205697Carcinoma, Spindle-Cell2CTD_human
TgeneTPM3C0205698Undifferentiated carcinoma2CTD_human
TgeneTPM3C0205699Carcinomatosis2CTD_human
TgeneTPM3C0206157Myopathies, Nemaline2GENOMICS_ENGLAND
TgeneTPM3C1257925Mammary Carcinoma, Animal2CTD_human
TgeneTPM3C0001418Adenocarcinoma1CTD_human
TgeneTPM3C0007102Malignant tumor of colon1CTD_human
TgeneTPM3C0009375Colonic Neoplasms1CTD_human
TgeneTPM3C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneTPM3C0024623Malignant neoplasm of stomach1CTD_human
TgeneTPM3C0038356Stomach Neoplasms1CTD_human
TgeneTPM3C0040136Thyroid Neoplasm1CTD_human
TgeneTPM3C0151468Thyroid Gland Follicular Adenoma1CTD_human
TgeneTPM3C0205641Adenocarcinoma, Basal Cell1CTD_human
TgeneTPM3C0205642Adenocarcinoma, Oxyphilic1CTD_human
TgeneTPM3C0205643Carcinoma, Cribriform1CTD_human
TgeneTPM3C0205644Carcinoma, Granular Cell1CTD_human
TgeneTPM3C0205645Adenocarcinoma, Tubular1CTD_human
TgeneTPM3C0270960Congenital myopathy (disorder)1GENOMICS_ENGLAND
TgeneTPM3C0334121Inflammatory Myofibroblastic Tumor1ORPHANET
TgeneTPM3C0546125Nemaline Myopathy, Childhood Onset1ORPHANET
TgeneTPM3C0549473Thyroid carcinoma1CTD_human
TgeneTPM3C1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneTPM3C3710589Cap Myopathy1ORPHANET