UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level3
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein Structure

leaf

pLDDT scores

leaf

Ramachandran Plot of Fusion Protein Structure

leaf

Potential Active Site Information

leaf

Potentially Interacting Small Molecules through Virtual Screening

leaf

Biochemical Features of Small Molecules with ADME

leaf

Drug Toxicity Information

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:RET-GOLGA5

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RET-GOLGA5
FusionPDB ID: 73558
FusionGDB2.0 ID: 73558
HgeneTgene
Gene symbol

RET

GOLGA5

Gene ID

5979

440270

Gene nameret proto-oncogenegolgin A8 family member B
SynonymsCDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1GOLGA5
Cytomap

10q11.21

15q14

Type of geneprotein-codingprotein-coding
Descriptionproto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullarygolgin subfamily A member 8Bgolgi autoantigen, golgin subfamily a, 8Bgolgin-67
Modification date2020032220200313
UniProtAcc

RTL1

Q8TBA6

Ensembl transtripts involved in fusion geneENST idsENST00000340058, ENST00000355710, 
ENST00000163416, ENST00000355976, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 6 X 4=21610 X 9 X 5=450
# samples 910
** MAII scorelog2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/450*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RET [Title/Abstract] AND GOLGA5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GOLGA5(93282767)-RET(43612030), # samples:2
Anticipated loss of major functional domain due to fusion event.GOLGA5-RET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GOLGA5-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRET

GO:0030155

regulation of cell adhesion

21357690

HgeneRET

GO:0030335

positive regulation of cell migration

20702524

HgeneRET

GO:0033619

membrane protein proteolysis

21357690

HgeneRET

GO:0033630

positive regulation of cell adhesion mediated by integrin

20702524

HgeneRET

GO:0035860

glial cell-derived neurotrophic factor receptor signaling pathway

28953886

HgeneRET

GO:0043410

positive regulation of MAPK cascade

28846099


check buttonFusion gene breakpoints across RET (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GOLGA5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..RETchr10

43610184

+GOLGA5chr14

93286052

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355710RETchr1043610184+ENST00000163416GOLGA5chr1493286052+359023682323072946
ENST00000355710RETchr1043610184+ENST00000355976GOLGA5chr1493286052+352223682322952906
ENST00000340058RETchr1043610184+ENST00000163416GOLGA5chr1493286052+353823161803020946
ENST00000340058RETchr1043610184+ENST00000355976GOLGA5chr1493286052+347023161802900906

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>73558_73558_1_RET-GOLGA5_RET_chr10_43610184_ENST00000340058_GOLGA5_chr14_93286052_ENST00000163416_length(amino acids)=946AA_BP=707
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILDMEAQQVN
EAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLT
ETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGIDNGEGTRLRNVPVLFNDTETNLAGMYGKVRKAASSIDQFSI

--------------------------------------------------------------

>73558_73558_2_RET-GOLGA5_RET_chr10_43610184_ENST00000340058_GOLGA5_chr14_93286052_ENST00000355976_length(amino acids)=906AA_BP=707
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILDMEAQQVN
EAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLT
ETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGIDNGEGTRLRNVPVLFNDTETNLAGMYGKVRKAASSIDQFRL

--------------------------------------------------------------

>73558_73558_3_RET-GOLGA5_RET_chr10_43610184_ENST00000355710_GOLGA5_chr14_93286052_ENST00000163416_length(amino acids)=946AA_BP=707
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILDMEAQQVN
EAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLT
ETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGIDNGEGTRLRNVPVLFNDTETNLAGMYGKVRKAASSIDQFSI

--------------------------------------------------------------

>73558_73558_4_RET-GOLGA5_RET_chr10_43610184_ENST00000355710_GOLGA5_chr14_93286052_ENST00000355976_length(amino acids)=906AA_BP=707
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILDMEAQQVN
EAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLT
ETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGIDNGEGTRLRNVPVLFNDTETNLAGMYGKVRKAASSIDQFRL

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:93282767/chr14:43612030)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RET

RTL1

GOLGA5

Q8TBA6

1358FUNCTION: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (706) >>>706.pdbFusion protein BP residue: 707
CIF file (706) >>>706.cif		RETchr1043610184+GOLGA5chr1493286052+
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPL
LYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRS
LDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFF
NTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNI
SVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAR
EEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFD
ADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRAT
VHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPV
SLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQL
LVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKG
ITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPR
GIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSV
LLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSM
ENQVSVDAFKILDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETEL
ERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQS
ELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSN
GSSINMSGIDNGEGTRLRNVPVLFNDTETNLAGMYGKVRKAASSIDQFRL
906
3D view using mol* of 706 (AA BP:707)
PDB file (727) >>>727.pdbFusion protein BP residue: 707
CIF file (727) >>>727.cif		RETchr1043610184+GOLGA5chr1493286052+
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPL
LYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRS
LDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFF
NTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNI
SVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAR
EEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFD
ADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRAT
VHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPV
SLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQL
LVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKG
ITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPR
GIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSV
LLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSM
ENQVSVDAFKILDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETEL
ERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQS
ELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSN
GSSINMSGIDNGEGTRLRNVPVLFNDTETNLAGMYGKVRKAASSIDQFSI
946
3D view using mol* of 727 (AA BP:707)


Top

pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
RET_pLDDT.png
all structure
all structure
GOLGA5_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
RET_GOLGA5_706_pLDDT.png (AA BP:707)
all structure
RET_GOLGA5_706_pLDDT_and_active_sites.png (AA BP:707)
all structure
RET_GOLGA5_706_violinplot.png (AA BP:707)
all structure
RET_GOLGA5_727_pLDDT.png (AA BP:707)
all structure
RET_GOLGA5_727_pLDDT_and_active_sites.png (AA BP:707)
all structure
RET_GOLGA5_727_violinplot.png (AA BP:707)
all structure


Top

Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
RET_GOLGA5_706.png
all structure
RET_GOLGA5_727.png
all structure

Top

Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
7060.9924341.0221339.0720.6090.6680.840.5210.9770.5330.615Chain A: 27,28,29,30,33,34,35,37,58,62,63,73,74,75
,76,77,116,117,118,119,120,122,124,127,129,130,132
,135,136,137,138,139,140,141,142,143,144,146,170,1
71,172,173,174,175,177,261,263,305,306,308,309,312
,313,380,817,821,824,825,828,829,831,832,833,835,8
36,837,880,881,882,883,884,885,886,887,888,889,890
,891,892,893,894,895,896,897,898,899
7271.062530.942389.3050.3960.7881.0750.4191.4430.290.713Chain A: 32,33,36,37,38,39,40,41,44,50,51,52,54,14
8,150,154,160,163,164,166,167,168,169,170,171,172,
174,185,186,187,188,189,190,191,192,193,204,241,25
6,258

Top

Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
727ZINC000000896546DB01099Flucytosine-7.61571-7.61621
727ZINC000000015515DB00315Zolmitriptan-7.11858-7.12248
727ZINC000000004321DB00909Zonisamide-6.98234-6.98374
727ZINC000000156395DB11102N-acetyltyrosine-6.80331-6.80331
727ZINC000000897256DB00983Formoterol-6.76819-6.78039
727ZINC000034676245DB00260Cycloserine-6.50913-6.75613
727ZINC000000001735DB00350Minoxidil-6.62335-6.62335
727ZINC000000000882DB00173Adenine-6.58845-6.60915
727ZINC000001531008DB13180Gluconic Acid-6.57144-6.57144
727ZINC000000001688DB00244Mesalazine-6.49834-6.50164
727ZINC000100007011DB00302Tranexamic acid-6.48918-6.48918
727ZINC000052971887DB06243Eflornithine-5.79156-6.37046
727ZINC000000056652DB01064Isoprenaline-6.36599-6.36599
727ZINC000000004166DB00489Sotalol-6.3347-6.3559
727ZINC000000895154DB00360Sapropterin-4.29686-6.32376
727ZINC000000057278DB00841Dobutamine-6.31383-6.31383
727ZINC000000403011DB00598Labetalol-6.23576-6.26336
727ZINC000000003911DB00841Dobutamine-6.25318-6.25318
727ZINC000000000922DB00233Aminosalicylic acid-6.24692-6.24782
727ZINC000001690604DB09352Hydroxyamphetamine-6.23746-6.23746

Top

check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000000896546DB01099FlucytosineSmall moleculeNC1=C(F)C=NC(=O)N1Approved|Investigational
ZINC000000015515DB00315ZolmitriptanSmall moleculeCN(C)CCC1=CNC2=CC=C(C[C@H]3COC(=O)N3)C=C12Approved|Investigational
ZINC000000004321DB00909ZonisamideSmall moleculeNS(=O)(=O)CC1=NOC2=CC=CC=C12Approved|Investigational
ZINC000000156395DB11102N-acetyltyrosineSmall moleculeCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=OApproved
ZINC000034676245DB00260CycloserineSmall moleculeN[C@@H]1CONC1=OApproved
ZINC000000001735DB00350MinoxidilSmall moleculeNC1=CC(=NC(N)=[N+]1[O-])N1CCCCC1Approved|Investigational
ZINC000000000882DB00173AdenineSmall moleculeNC1=C2NC=NC2=NC=N1Approved|Nutraceutical
ZINC000001531008DB13180Gluconic AcidSmall moleculeOC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=OApproved|Investigational
ZINC000000001688DB00244MesalazineSmall moleculeNC1=CC(C(O)=O)=C(O)C=C1Approved
ZINC000000895154DB00360SapropterinSmall molecule[H][C@@]1(CNC2=C(N1)C(=O)NC(N)=N2)[C@@H](O)[C@H](C)OApproved|Investigational
ZINC000000403011DB00598LabetalolSmall moleculeCC(CCC1=CC=CC=C1)NCC(O)C1=CC(C(N)=O)=C(O)C=C1Approved
ZINC000000003911DB00841DobutamineSmall moleculeCC(CCC1=CC=C(O)C=C1)NCCC1=CC(O)=C(O)C=C1Approved
ZINC000000000922DB00233Aminosalicylic acidSmall moleculeNC1=CC(O)=C(C=C1)C(O)=OApproved

Top

Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000000896546129.0945.933283.8030174.82165.19643.787412.204349.417259.95700
ZINC000000015515287.3618.8554.37281.737133.727138.9070978.15825.58.494375.10700
ZINC000000004321212.2236.978398.51740.32185.554172.6440642.453269.667365.95900
ZINC000000156395223.2288.235457.265130.328191.716135.220758.2822.254.58.821256.57400
ZINC000000897256344.415.264632.493247.284157.494227.71501135.04847.28.825370.83700
ZINC000000897256344.416.478644.939257.318179.642207.97901149.05747.28.565266.25100
ZINC000034676245102.0934.945262.74482.71180.03400374.74635.29.761245.72700
ZINC000034676245102.0934.751261.73782.916178.82200371.29335.29.725245.88500
ZINC000000001735209.255.141437.436217.593169.97449.8690711.86443.57.733376.87300
ZINC000000000882135.1282.734303.1530170.481132.6720451.892348.538368.3800
ZINC000000000882135.1289.438304.2780171.466132.8120454.287348.639368.21400
ZINC000001531008196.1575.428382.2596.327285.92300612.09959.510.764215.55511
ZINC000000001688153.1374.232332.7310205.917126.8140509.6792.52.758.076254.8900
ZINC000100007011157.2121.799375.783216.456159.32700603.499339.574242.47101
ZINC000052971887182.174.815375.577120.033183.002072.541593.19549.616119.75201
ZINC000052971887182.174.577376.305117.956183.727074.623594.335549.723119.67801
ZINC000000056652211.263.507478.577212.52152.49113.5670781.05944.78.941263.0100
ZINC000000004166272.3625.095568.775304.129140.425123.7780.442948.34737.79.15365.28500
ZINC000000004166272.3626.328565.576303.726137.239124.5690.042941.28337.79.164365.81400
ZINC000000895154241.2496.373456.659158.621275.2722.7690751.10678.97.413228.07410
ZINC000000895154241.24911.58456.496158.427275.45422.6150751.97778.97.547228.07210
ZINC000000057278301.3853.184635.705195.256167.859272.59101080.62243.758.881373.6600
ZINC000000403011328.415.963663.486168.781199.564295.14101140.57745.459.137270.60500
ZINC000000403011328.415.239606.942175.803170.799260.3401103.55145.459.225375.4400
ZINC000000003911301.3852.633634.995197.902166.354270.7401079.41443.758.882373.92100
ZINC000000000922153.1376.332333.640206.343127.2970510.5472.52.758.479254.82800
ZINC000001690604151.2082.431381.982132.371102.154147.4570607.60931.759.08375.00300


Top

Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000000896546Nc1nc(=O)[nH]cc1F0.1160196950.475808288
ZINC000000015515CN(C)CCc1c[nH]c2ccc(C[C@H]3COC(=O)N3)cc120.1279753690.361563414
ZINC000000004321NS(=O)(=O)Cc1noc2ccccc120.2545692540.46155884
ZINC000000156395CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O0.318551410.320963032
ZINC000000897256COc1ccc(C[C@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc10.1338630780.246482573
ZINC000034676245N[C@@H]1CON=C1O0.0253140150.650044735
ZINC000000001735Nc1cc(N2CCCCC2)nc(N)[n+]1[O-]0.1297409460.395964399
ZINC000000000882Nc1ncnc2[nH]cnc120.1746372290.465480638
ZINC000001531008O=C(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO0.0747717210.544145977
ZINC000000001688Nc1ccc(O)c(C(=O)O)c10.4488432760.439462293
ZINC000100007011NC[C@@H]1CC[C@@H](C(=O)O)CC10.343577740.472488357
ZINC000052971887NCCC[C@](N)(C(=O)O)C(F)F0.0864132840.375086254
ZINC000000056652CC(C)NC[C@H](O)c1ccc(O)c(O)c10.2021505940.209218132
ZINC000000004166CC(C)NC[C@@H](O)c1ccc(NS(C)(=O)=O)cc10.2338358740.174875168
ZINC000000895154C[C@@H](O)[C@H](O)[C@@H]1CNc2[nH]c(N)nc(=O)c2N10.0371845340.22690944
ZINC000000057278C[C@@H](CCc1ccc(O)cc1)NCCc1ccc(O)c(O)c10.2222740840.261336882
ZINC000000403011C[C@@H](CCc1ccccc1)NC[C@@H](O)c1ccc(O)c(C(N)=O)c10.1638887930.349082082
ZINC000000003911C[C@H](CCc1ccc(O)cc1)NCCc1ccc(O)c(O)c10.2222740840.261336882
ZINC000000000922Nc1ccc(C(=O)O)c(O)c10.4164916230.463983011
ZINC000001690604C[C@H](N)Cc1ccc(O)cc10.3184961330.39446034


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
GOLGA5RAB1A, OCRL, ITSN1, SPINT2, CD27, ASGR2, CEACAM21, TEX29, SLC39A4, P2RY12, POMK, B4GALT3, CCDC151, LPAR1, TMEM17, TMEM216, CDC42, XRCC5, ZNF281, TMEM132A, Kcnk1, Mis12, Trip11, Sidt2, PTAR1, CDH1, MTMR4, C3AR1, SLC6A15, IPPK, CCDC107, YIPF3, HTR2C, EXOC1, CD79B, SPPL2B, ZFYVE27, CHST14, GPR161, AOC2, ATP2B2, SLC6A5, STS, SYNC, TACR1, ADAM21, PKN3, NCKAP5L, TFPT, CCHCR1, YEATS4, TUFT1, RABGAP1L, CLOCK, PSMD9, VPS53, DZIP3, GRIPAP1, RCOR1, HMG20A, CCDC132, CCDC93, OIP5, PHF21A, GIT2, PTRF, PHLDB3, HAUS6, RPRD1A, ARNTL, MAX, RABGEF1, NUF2, THAP11, VPS51, TSSC1, RABEP1, KDM1A, STRN, NCDN, BRCA1, RNF4, ESR2, NRAS, BET1, RAB9A, GOLGA2, TGOLN2, GBF1, HOOK3, PEBP1, FAM105A, PLEKHA4, ORF3a, ORF7b, E, nsp4, nsp6, ORF6, ORF7a, NEK4, C17orf80, SEC62, Rnf183, GGA2, DNAJC5, ARF6, B3GAT1, CAV1, EBAG9, ELOVL5, EMD, ERGIC1, ERGIC2, GJA1, GJD3, GOLGA1, GORASP1, HSD17B11, HSD3B7, LAMP2, LAMP3, LAMTOR1, LCK, MARCKS, METTL7A, NUP155, OCLN, PXMP2, RAB11A, RAB2A, RAB35, RAB3B, RAB4A, RAB5A, RAB5C, REEP5, STX4, STX6, STX7, TMPO, ZFPL1, NAA40, VPS33B, ENTPD2, GABBR1, C5AR1, PTH1R, CCR6, SLC5A4, AVPR2, OR13J1, CACNG6, TMEM9, GPR17, TAS2R19, VSTM1, KCNJ6, NIPAL1, KRTCAP3, KDSR, HPN, RNF149, TNFSF18, CYB5B, TTYH1, EXTL3, TSPAN10, P2RY2, KCNK4, ADORA2B, HTR1B, GPR173, LPAR2, SCAMP2, PTAFR, SLC2A8, F2RL1, ZDHHC12, FZD7, GPR35, TSPAN15, CD97, ACKR2, CD151, ATP5C1, SYNGR1, ATP5J, S1PR4,
RETSTAT3, DOK6, DOK5, SRC, SHC1, PTPRF, DOK2, DOK4, DOK1, GRB2, CRK, PLCG1, PDLIM7, GRB7, FRS2, NRTN, GFRA1, GRB10, IKBKG, MCRS1, CBL, CBLC, RET, HSP90AA1, NOTCH2NL, NOTCH3, AIP, EGFR, NTRK1, ZBTB48, HNRNPD, SORT1, SYNCRIP, SGTB, BAG6, HIST1H3A, KYNU, TXNL4A, ZCCHC8, ICE2, MAPK3, PTK2, MAPK1, PTPRR, DUSP26, Shc1, PIK3R1, FBXO7, NEDD4, SHANK2, LRRK1, PTK6, CTNNB1, SHC4, ERBB2, ADAM10, SPINT2, PCDH7, LRIG2, APP, GDNF, IGF1R, CLU, EPCAM, CDH2, TGFBR1, PTK7, FAT1, DHCR24, SMN1, PCDH19, NCSTN, CERS2, CHP1, FANCD2, ITM2C, SEL1L, PCDHGB5, CKB, NRP1, PLXNB2, NCK2, CTNND1, TULP3, PTPN1, NF2, CRKL, CAMLG, NUMB, BASP1, ROR2, NOTCH2, PTPN13, ANK3, RAB3GAP1, PEA15, LLGL1, GPRIN3, RAPH1, MARK2, CYFIP1, ARC, GPRIN1, ANKLE2, VRK2, MIB1, PHACTR4, UNC5B, TMEM57, SYAP1, FAF2, ERBB2IP, FAM129B, KIAA1715, PEAK1, VANGL2, BAIAP2, EPN1, NUMBL, PRKAR2A, GAB1, PTPRA, DDX39A, TIMP1, EPHB4, MANEA, SRY, RABAC1, LEMD3, TMEM214, PDZD8, GPR50, SMIM5, RNF149, SDF2L1, BMPR1A, PLEKHH3, ACVR2A,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RETall structure
GOLGA5all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to RET-GOLGA5


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to RET-GOLGA5


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRETC1833921Familial medullary thyroid carcinoma23CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneRETC3888239HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 116GENOMICS_ENGLAND;UNIPROT
HgeneRETC0025268Multiple Endocrine Neoplasia Type 2a15CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneRETC1708353Hereditary Paraganglioma-Pheochromocytoma Syndrome12CLINGEN
HgeneRETC0025269Multiple Endocrine Neoplasia Type 2b10CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneRETC0238463Papillary thyroid carcinoma3CTD_human;ORPHANET
HgeneRETC1275808Congenital central hypoventilation3CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneRETC1859049CCHS WITH HIRSCHSPRUNG DISEASE3CTD_human;ORPHANET
HgeneRETC0009402Colorectal Carcinoma2CTD_human;UNIPROT
HgeneRETC0009404Colorectal Neoplasms2CTD_human
HgeneRETC0019569Hirschsprung Disease2CTD_human
HgeneRETC0027662Multiple Endocrine Neoplasia2CTD_human;GENOMICS_ENGLAND
HgeneRETC0085758Aganglionosis, Colonic2CTD_human
HgeneRETC0266294Unilateral agenesis of kidney2ORPHANET
HgeneRETC1257840Aganglionosis, Rectosigmoid Colon2CTD_human
HgeneRETC3661523Congenital Intestinal Aganglionosis2CTD_human
HgeneRETC0006413Burkitt Lymphoma1CTD_human
HgeneRETC0031511Pheochromocytoma1CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneRETC0038220Status Epilepticus1CTD_human
HgeneRETC0040136Thyroid Neoplasm1CGI;CTD_human
HgeneRETC0151468Thyroid Gland Follicular Adenoma1CTD_human
HgeneRETC0206693Medullary carcinoma1CTD_human
HgeneRETC0238462Medullary carcinoma of thyroid1CGI;CTD_human
HgeneRETC0270823Petit mal status1CTD_human
HgeneRETC0311335Grand Mal Status Epilepticus1CTD_human
HgeneRETC0343640African Burkitt's lymphoma1CTD_human
HgeneRETC0393734Complex Partial Status Epilepticus1CTD_human
HgeneRETC0549473Thyroid carcinoma1CGI;CTD_human;UNIPROT
HgeneRETC0740340Amyloidosis, Familial1CTD_human
HgeneRETC0751522Status Epilepticus, Subclinical1CTD_human
HgeneRETC0751523Non-Convulsive Status Epilepticus1CTD_human
HgeneRETC0751524Simple Partial Status Epilepticus1CTD_human
HgeneRETC1257877Pheochromocytoma, Extra-Adrenal1CTD_human
HgeneRETC1609433Congenital absence of kidneys syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneRETC3501843Nonmedullary Thyroid Carcinoma1CTD_human
HgeneRETC3501844Familial Nonmedullary Thyroid Cancer1CTD_human
HgeneRETC4721444Burkitt Leukemia1CTD_human
TgeneGOLGA5C0238463Papillary thyroid carcinoma2ORPHANET