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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:REV3L-LAMA4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: REV3L-LAMA4
FusionPDB ID: 73589
FusionGDB2.0 ID: 73589
HgeneTgene
Gene symbol

REV3L

LAMA4

Gene ID

5980

3910

Gene nameREV3 like, DNA directed polymerase zeta catalytic subunitlaminin subunit alpha 4
SynonymsPOLZ|REV3CMD1JJ|LAMA3|LAMA4*-1
Cytomap

6q21

6q21

Type of geneprotein-codingprotein-coding
DescriptionDNA polymerase zeta catalytic subunitREV3-like, polymerase (DNA directed), zeta, catalytic subunitRev-3, yeast, homolog-like (polymerase, DNA, zeta)laminin subunit alpha-4laminin alpha 4 chainlaminin, alpha 4
Modification date2020031320200313
UniProtAcc.

Q16363

Ensembl transtripts involved in fusion geneENST idsENST00000358835, ENST00000368802, 
ENST00000368805, ENST00000435970, 
ENST00000462119, 		ENST00000368638, 
ENST00000431543, ENST00000453937, 
ENST00000524032, ENST00000230538, 
ENST00000389463, ENST00000424408, 
ENST00000522006, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 20 X 10=34009 X 7 X 7=441
# samples 269
** MAII scorelog2(26/3400*10)=-3.70895121799661
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/441*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: REV3L [Title/Abstract] AND LAMA4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)REV3L(111803953)-LAMA4(112466135), # samples:2
Anticipated loss of major functional domain due to fusion event.REV3L-LAMA4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
REV3L-LAMA4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
REV3L-LAMA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
REV3L-LAMA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across REV3L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LAMA4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A8ID-01AREV3Lchr6

111803953

-LAMA4chr6

112466135

-
ChimerDB4PRADTCGA-KK-A8IDREV3Lchr6

111803953

-LAMA4chr6

112466135

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000368805REV3Lchr6111803953-ENST00000230538LAMA4chr6112466135-40182228333401085
ENST00000368805REV3Lchr6111803953-ENST00000522006LAMA4chr6112466135-39182228333401085
ENST00000368805REV3Lchr6111803953-ENST00000389463LAMA4chr6112466135-39042228333401085
ENST00000368805REV3Lchr6111803953-ENST00000424408LAMA4chr6112466135-34852228333401085
ENST00000358835REV3Lchr6111803953-ENST00000230538LAMA4chr6112466135-439059445537121085
ENST00000358835REV3Lchr6111803953-ENST00000522006LAMA4chr6112466135-429059445537121085
ENST00000358835REV3Lchr6111803953-ENST00000389463LAMA4chr6112466135-427659445537121085
ENST00000358835REV3Lchr6111803953-ENST00000424408LAMA4chr6112466135-385759445537121085

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368805ENST00000230538REV3Lchr6111803953-LAMA4chr6112466135-0.0001622410.99983776
ENST00000368805ENST00000522006REV3Lchr6111803953-LAMA4chr6112466135-0.0001813560.9998186
ENST00000368805ENST00000389463REV3Lchr6111803953-LAMA4chr6112466135-0.0001838710.9998161
ENST00000368805ENST00000424408REV3Lchr6111803953-LAMA4chr6112466135-0.0002524170.9997476
ENST00000358835ENST00000230538REV3Lchr6111803953-LAMA4chr6112466135-0.0003129650.9996871
ENST00000358835ENST00000522006REV3Lchr6111803953-LAMA4chr6112466135-0.0003532510.9996468
ENST00000358835ENST00000389463REV3Lchr6111803953-LAMA4chr6112466135-0.0003570480.99964297
ENST00000358835ENST00000424408REV3Lchr6111803953-LAMA4chr6112466135-0.0004968390.99950314

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>73589_73589_1_REV3L-LAMA4_REV3L_chr6_111803953_ENST00000358835_LAMA4_chr6_112466135_ENST00000230538_length(amino acids)=1085AA_BP=45
MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAVRNLTEVVPQLLDQLRTVEQKRPASNVSASIQRIRELIAQTRSV
ASKIQVSMMFDGQSAVEVHSRTSMDDLKAFTSLSLYMKPPVKRPELTETADQFILYLGSKNAKKEYMGLAIKNDNLVYVYNLGTKDVEIP
LDSKPVSSWPAYFSIVKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFKLPTSLNLPGFVGCLEL
ATLNNDVISLYNFKHIYNMDPSTSVPCARDKLAFTQSRAASYFFDGSGYAVVRDITRRGKFGQVTRFDIEVRTPADNGLILLMVNGSMFF
RLEMRNGYLHVFYDFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVVDRRHVKSMDNEKMKIPFTDIYIGGAPPEILQSRAL
RAHLPLDINFRGCMKGFQFQKKDFNLLEQTETLGVGYGCPEDSLISRRAYFNGQSFIASIQKISFFDGFEGGFNFRTLQPNGLLFYYASG
SDVFSISLDNGTVIMDVKGIKVQSVDKQYNDGLSHFVISSVSPTRYELIVDKSRVGSKNPTKGKIEQTQASEKKFYFGGSPISAQYANFT
GCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLHKKGKNLSKPKASQNKKGGKSKDAPSWDPVALKLPERNTPRNSHCH
LSNSPRAIEHAYQYGGTANSRQEFEHLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQEKY
NDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGKAVKNVQINSIYSFSGCLSNLQLNGASITSASQTFSVT
PCFEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSVNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCD
GRWHRITVIRDSNVVQLDVDSEVNHVVGPLNPKPIDHREPVFVGGVPESLLTPRLAPSKPFTGCIRHFVIDGHPVSFSKAALVSGAVSIN

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>73589_73589_2_REV3L-LAMA4_REV3L_chr6_111803953_ENST00000358835_LAMA4_chr6_112466135_ENST00000389463_length(amino acids)=1085AA_BP=45
MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAVRNLTEVVPQLLDQLRTVEQKRPASNVSASIQRIRELIAQTRSV
ASKIQVSMMFDGQSAVEVHSRTSMDDLKAFTSLSLYMKPPVKRPELTETADQFILYLGSKNAKKEYMGLAIKNDNLVYVYNLGTKDVEIP
LDSKPVSSWPAYFSIVKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFKLPTSLNLPGFVGCLEL
ATLNNDVISLYNFKHIYNMDPSTSVPCARDKLAFTQSRAASYFFDGSGYAVVRDITRRGKFGQVTRFDIEVRTPADNGLILLMVNGSMFF
RLEMRNGYLHVFYDFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVVDRRHVKSMDNEKMKIPFTDIYIGGAPPEILQSRAL
RAHLPLDINFRGCMKGFQFQKKDFNLLEQTETLGVGYGCPEDSLISRRAYFNGQSFIASIQKISFFDGFEGGFNFRTLQPNGLLFYYASG
SDVFSISLDNGTVIMDVKGIKVQSVDKQYNDGLSHFVISSVSPTRYELIVDKSRVGSKNPTKGKIEQTQASEKKFYFGGSPISAQYANFT
GCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLHKKGKNLSKPKASQNKKGGKSKDAPSWDPVALKLPERNTPRNSHCH
LSNSPRAIEHAYQYGGTANSRQEFEHLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQEKY
NDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGKAVKNVQINSIYSFSGCLSNLQLNGASITSASQTFSVT
PCFEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSVNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCD
GRWHRITVIRDSNVVQLDVDSEVNHVVGPLNPKPIDHREPVFVGGVPESLLTPRLAPSKPFTGCIRHFVIDGHPVSFSKAALVSGAVSIN

--------------------------------------------------------------

>73589_73589_3_REV3L-LAMA4_REV3L_chr6_111803953_ENST00000358835_LAMA4_chr6_112466135_ENST00000424408_length(amino acids)=1085AA_BP=45
MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAVRNLTEVVPQLLDQLRTVEQKRPASNVSASIQRIRELIAQTRSV
ASKIQVSMMFDGQSAVEVHSRTSMDDLKAFTSLSLYMKPPVKRPELTETADQFILYLGSKNAKKEYMGLAIKNDNLVYVYNLGTKDVEIP
LDSKPVSSWPAYFSIVKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFKLPTSLNLPGFVGCLEL
ATLNNDVISLYNFKHIYNMDPSTSVPCARDKLAFTQSRAASYFFDGSGYAVVRDITRRGKFGQVTRFDIEVRTPADNGLILLMVNGSMFF
RLEMRNGYLHVFYDFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVVDRRHVKSMDNEKMKIPFTDIYIGGAPPEILQSRAL
RAHLPLDINFRGCMKGFQFQKKDFNLLEQTETLGVGYGCPEDSLISRRAYFNGQSFIASIQKISFFDGFEGGFNFRTLQPNGLLFYYASG
SDVFSISLDNGTVIMDVKGIKVQSVDKQYNDGLSHFVISSVSPTRYELIVDKSRVGSKNPTKGKIEQTQASEKKFYFGGSPISAQYANFT
GCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLHKKGKNLSKPKASQNKKGGKSKDAPSWDPVALKLPERNTPRNSHCH
LSNSPRAIEHAYQYGGTANSRQEFEHLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQEKY
NDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGKAVKNVQINSIYSFSGCLSNLQLNGASITSASQTFSVT
PCFEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSVNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCD
GRWHRITVIRDSNVVQLDVDSEVNHVVGPLNPKPIDHREPVFVGGVPESLLTPRLAPSKPFTGCIRHFVIDGHPVSFSKAALVSGAVSIN

--------------------------------------------------------------

>73589_73589_4_REV3L-LAMA4_REV3L_chr6_111803953_ENST00000358835_LAMA4_chr6_112466135_ENST00000522006_length(amino acids)=1085AA_BP=45
MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAVRNLTEVVPQLLDQLRTVEQKRPASNVSASIQRIRELIAQTRSV
ASKIQVSMMFDGQSAVEVHSRTSMDDLKAFTSLSLYMKPPVKRPELTETADQFILYLGSKNAKKEYMGLAIKNDNLVYVYNLGTKDVEIP
LDSKPVSSWPAYFSIVKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFKLPTSLNLPGFVGCLEL
ATLNNDVISLYNFKHIYNMDPSTSVPCARDKLAFTQSRAASYFFDGSGYAVVRDITRRGKFGQVTRFDIEVRTPADNGLILLMVNGSMFF
RLEMRNGYLHVFYDFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVVDRRHVKSMDNEKMKIPFTDIYIGGAPPEILQSRAL
RAHLPLDINFRGCMKGFQFQKKDFNLLEQTETLGVGYGCPEDSLISRRAYFNGQSFIASIQKISFFDGFEGGFNFRTLQPNGLLFYYASG
SDVFSISLDNGTVIMDVKGIKVQSVDKQYNDGLSHFVISSVSPTRYELIVDKSRVGSKNPTKGKIEQTQASEKKFYFGGSPISAQYANFT
GCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLHKKGKNLSKPKASQNKKGGKSKDAPSWDPVALKLPERNTPRNSHCH
LSNSPRAIEHAYQYGGTANSRQEFEHLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQEKY
NDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGKAVKNVQINSIYSFSGCLSNLQLNGASITSASQTFSVT
PCFEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSVNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCD
GRWHRITVIRDSNVVQLDVDSEVNHVVGPLNPKPIDHREPVFVGGVPESLLTPRLAPSKPFTGCIRHFVIDGHPVSFSKAALVSGAVSIN

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>73589_73589_5_REV3L-LAMA4_REV3L_chr6_111803953_ENST00000368805_LAMA4_chr6_112466135_ENST00000230538_length(amino acids)=1085AA_BP=45
MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAVRNLTEVVPQLLDQLRTVEQKRPASNVSASIQRIRELIAQTRSV
ASKIQVSMMFDGQSAVEVHSRTSMDDLKAFTSLSLYMKPPVKRPELTETADQFILYLGSKNAKKEYMGLAIKNDNLVYVYNLGTKDVEIP
LDSKPVSSWPAYFSIVKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFKLPTSLNLPGFVGCLEL
ATLNNDVISLYNFKHIYNMDPSTSVPCARDKLAFTQSRAASYFFDGSGYAVVRDITRRGKFGQVTRFDIEVRTPADNGLILLMVNGSMFF
RLEMRNGYLHVFYDFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVVDRRHVKSMDNEKMKIPFTDIYIGGAPPEILQSRAL
RAHLPLDINFRGCMKGFQFQKKDFNLLEQTETLGVGYGCPEDSLISRRAYFNGQSFIASIQKISFFDGFEGGFNFRTLQPNGLLFYYASG
SDVFSISLDNGTVIMDVKGIKVQSVDKQYNDGLSHFVISSVSPTRYELIVDKSRVGSKNPTKGKIEQTQASEKKFYFGGSPISAQYANFT
GCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLHKKGKNLSKPKASQNKKGGKSKDAPSWDPVALKLPERNTPRNSHCH
LSNSPRAIEHAYQYGGTANSRQEFEHLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQEKY
NDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGKAVKNVQINSIYSFSGCLSNLQLNGASITSASQTFSVT
PCFEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSVNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCD
GRWHRITVIRDSNVVQLDVDSEVNHVVGPLNPKPIDHREPVFVGGVPESLLTPRLAPSKPFTGCIRHFVIDGHPVSFSKAALVSGAVSIN

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>73589_73589_6_REV3L-LAMA4_REV3L_chr6_111803953_ENST00000368805_LAMA4_chr6_112466135_ENST00000389463_length(amino acids)=1085AA_BP=45
MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAVRNLTEVVPQLLDQLRTVEQKRPASNVSASIQRIRELIAQTRSV
ASKIQVSMMFDGQSAVEVHSRTSMDDLKAFTSLSLYMKPPVKRPELTETADQFILYLGSKNAKKEYMGLAIKNDNLVYVYNLGTKDVEIP
LDSKPVSSWPAYFSIVKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFKLPTSLNLPGFVGCLEL
ATLNNDVISLYNFKHIYNMDPSTSVPCARDKLAFTQSRAASYFFDGSGYAVVRDITRRGKFGQVTRFDIEVRTPADNGLILLMVNGSMFF
RLEMRNGYLHVFYDFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVVDRRHVKSMDNEKMKIPFTDIYIGGAPPEILQSRAL
RAHLPLDINFRGCMKGFQFQKKDFNLLEQTETLGVGYGCPEDSLISRRAYFNGQSFIASIQKISFFDGFEGGFNFRTLQPNGLLFYYASG
SDVFSISLDNGTVIMDVKGIKVQSVDKQYNDGLSHFVISSVSPTRYELIVDKSRVGSKNPTKGKIEQTQASEKKFYFGGSPISAQYANFT
GCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLHKKGKNLSKPKASQNKKGGKSKDAPSWDPVALKLPERNTPRNSHCH
LSNSPRAIEHAYQYGGTANSRQEFEHLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQEKY
NDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGKAVKNVQINSIYSFSGCLSNLQLNGASITSASQTFSVT
PCFEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSVNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCD
GRWHRITVIRDSNVVQLDVDSEVNHVVGPLNPKPIDHREPVFVGGVPESLLTPRLAPSKPFTGCIRHFVIDGHPVSFSKAALVSGAVSIN

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>73589_73589_7_REV3L-LAMA4_REV3L_chr6_111803953_ENST00000368805_LAMA4_chr6_112466135_ENST00000424408_length(amino acids)=1085AA_BP=45
MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAVRNLTEVVPQLLDQLRTVEQKRPASNVSASIQRIRELIAQTRSV
ASKIQVSMMFDGQSAVEVHSRTSMDDLKAFTSLSLYMKPPVKRPELTETADQFILYLGSKNAKKEYMGLAIKNDNLVYVYNLGTKDVEIP
LDSKPVSSWPAYFSIVKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFKLPTSLNLPGFVGCLEL
ATLNNDVISLYNFKHIYNMDPSTSVPCARDKLAFTQSRAASYFFDGSGYAVVRDITRRGKFGQVTRFDIEVRTPADNGLILLMVNGSMFF
RLEMRNGYLHVFYDFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVVDRRHVKSMDNEKMKIPFTDIYIGGAPPEILQSRAL
RAHLPLDINFRGCMKGFQFQKKDFNLLEQTETLGVGYGCPEDSLISRRAYFNGQSFIASIQKISFFDGFEGGFNFRTLQPNGLLFYYASG
SDVFSISLDNGTVIMDVKGIKVQSVDKQYNDGLSHFVISSVSPTRYELIVDKSRVGSKNPTKGKIEQTQASEKKFYFGGSPISAQYANFT
GCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLHKKGKNLSKPKASQNKKGGKSKDAPSWDPVALKLPERNTPRNSHCH
LSNSPRAIEHAYQYGGTANSRQEFEHLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQEKY
NDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGKAVKNVQINSIYSFSGCLSNLQLNGASITSASQTFSVT
PCFEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSVNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCD
GRWHRITVIRDSNVVQLDVDSEVNHVVGPLNPKPIDHREPVFVGGVPESLLTPRLAPSKPFTGCIRHFVIDGHPVSFSKAALVSGAVSIN

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>73589_73589_8_REV3L-LAMA4_REV3L_chr6_111803953_ENST00000368805_LAMA4_chr6_112466135_ENST00000522006_length(amino acids)=1085AA_BP=45
MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAVRNLTEVVPQLLDQLRTVEQKRPASNVSASIQRIRELIAQTRSV
ASKIQVSMMFDGQSAVEVHSRTSMDDLKAFTSLSLYMKPPVKRPELTETADQFILYLGSKNAKKEYMGLAIKNDNLVYVYNLGTKDVEIP
LDSKPVSSWPAYFSIVKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFKLPTSLNLPGFVGCLEL
ATLNNDVISLYNFKHIYNMDPSTSVPCARDKLAFTQSRAASYFFDGSGYAVVRDITRRGKFGQVTRFDIEVRTPADNGLILLMVNGSMFF
RLEMRNGYLHVFYDFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVVDRRHVKSMDNEKMKIPFTDIYIGGAPPEILQSRAL
RAHLPLDINFRGCMKGFQFQKKDFNLLEQTETLGVGYGCPEDSLISRRAYFNGQSFIASIQKISFFDGFEGGFNFRTLQPNGLLFYYASG
SDVFSISLDNGTVIMDVKGIKVQSVDKQYNDGLSHFVISSVSPTRYELIVDKSRVGSKNPTKGKIEQTQASEKKFYFGGSPISAQYANFT
GCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLHKKGKNLSKPKASQNKKGGKSKDAPSWDPVALKLPERNTPRNSHCH
LSNSPRAIEHAYQYGGTANSRQEFEHLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQEKY
NDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGKAVKNVQINSIYSFSGCLSNLQLNGASITSASQTFSVT
PCFEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSVNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCD
GRWHRITVIRDSNVVQLDVDSEVNHVVGPLNPKPIDHREPVFVGGVPESLLTPRLAPSKPFTGCIRHFVIDGHPVSFSKAALVSGAVSIN

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:111803953/chr6:112466135)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LAMA4

Q16363

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLAMA4chr6:111803953chr6:112466135ENST0000036863802320_4030121.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST0000036863802473_5280121.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST0000036863802581_6140121.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST0000036863802662_7240121.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST0000036863802777_8060121.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST000003894631739777_806777.33333333333341817.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST000004244081638777_806777.33333333333341817.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST0000045393702320_4030121.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST0000045393702473_5280121.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST0000045393702581_6140121.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST0000045393702662_7240121.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST0000045393702777_8060121.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST000005220061739777_806777.33333333333341817.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST0000023053817391047_1227784.33333333333341824.0DomainLaminin G-like 2
TgeneLAMA4chr6:111803953chr6:112466135ENST0000023053817391234_1402784.33333333333341824.0DomainLaminin G-like 3
TgeneLAMA4chr6:111803953chr6:112466135ENST0000023053817391469_1640784.33333333333341824.0DomainLaminin G-like 4
TgeneLAMA4chr6:111803953chr6:112466135ENST0000023053817391647_1820784.33333333333341824.0DomainLaminin G-like 5
TgeneLAMA4chr6:111803953chr6:112466135ENST000002305381739833_1035784.33333333333341824.0DomainLaminin G-like 1
TgeneLAMA4chr6:111803953chr6:112466135ENST00000368638021047_12270121.0DomainLaminin G-like 2
TgeneLAMA4chr6:111803953chr6:112466135ENST00000368638021234_14020121.0DomainLaminin G-like 3
TgeneLAMA4chr6:111803953chr6:112466135ENST0000036863802132_1860121.0DomainLaminin EGF-like 2
TgeneLAMA4chr6:111803953chr6:112466135ENST00000368638021469_16400121.0DomainLaminin G-like 4
TgeneLAMA4chr6:111803953chr6:112466135ENST00000368638021647_18200121.0DomainLaminin G-like 5
TgeneLAMA4chr6:111803953chr6:112466135ENST0000036863802187_2400121.0DomainLaminin EGF-like 3
TgeneLAMA4chr6:111803953chr6:112466135ENST0000036863802241_2550121.0DomainLaminin EGF-like 4%3B truncated
TgeneLAMA4chr6:111803953chr6:112466135ENST000003686380282_1310121.0DomainLaminin EGF-like 1
TgeneLAMA4chr6:111803953chr6:112466135ENST0000036863802833_10350121.0DomainLaminin G-like 1
TgeneLAMA4chr6:111803953chr6:112466135ENST0000038946317391047_1227777.33333333333341817.0DomainLaminin G-like 2
TgeneLAMA4chr6:111803953chr6:112466135ENST0000038946317391234_1402777.33333333333341817.0DomainLaminin G-like 3
TgeneLAMA4chr6:111803953chr6:112466135ENST0000038946317391469_1640777.33333333333341817.0DomainLaminin G-like 4
TgeneLAMA4chr6:111803953chr6:112466135ENST0000038946317391647_1820777.33333333333341817.0DomainLaminin G-like 5
TgeneLAMA4chr6:111803953chr6:112466135ENST000003894631739833_1035777.33333333333341817.0DomainLaminin G-like 1
TgeneLAMA4chr6:111803953chr6:112466135ENST0000042440816381047_1227777.33333333333341817.0DomainLaminin G-like 2
TgeneLAMA4chr6:111803953chr6:112466135ENST0000042440816381234_1402777.33333333333341817.0DomainLaminin G-like 3
TgeneLAMA4chr6:111803953chr6:112466135ENST0000042440816381469_1640777.33333333333341817.0DomainLaminin G-like 4
TgeneLAMA4chr6:111803953chr6:112466135ENST0000042440816381647_1820777.33333333333341817.0DomainLaminin G-like 5
TgeneLAMA4chr6:111803953chr6:112466135ENST000004244081638833_1035777.33333333333341817.0DomainLaminin G-like 1
TgeneLAMA4chr6:111803953chr6:112466135ENST00000453937021047_12270121.0DomainLaminin G-like 2
TgeneLAMA4chr6:111803953chr6:112466135ENST00000453937021234_14020121.0DomainLaminin G-like 3
TgeneLAMA4chr6:111803953chr6:112466135ENST0000045393702132_1860121.0DomainLaminin EGF-like 2
TgeneLAMA4chr6:111803953chr6:112466135ENST00000453937021469_16400121.0DomainLaminin G-like 4
TgeneLAMA4chr6:111803953chr6:112466135ENST00000453937021647_18200121.0DomainLaminin G-like 5
TgeneLAMA4chr6:111803953chr6:112466135ENST0000045393702187_2400121.0DomainLaminin EGF-like 3
TgeneLAMA4chr6:111803953chr6:112466135ENST0000045393702241_2550121.0DomainLaminin EGF-like 4%3B truncated
TgeneLAMA4chr6:111803953chr6:112466135ENST000004539370282_1310121.0DomainLaminin EGF-like 1
TgeneLAMA4chr6:111803953chr6:112466135ENST0000045393702833_10350121.0DomainLaminin G-like 1
TgeneLAMA4chr6:111803953chr6:112466135ENST0000052200617391047_1227777.33333333333341817.0DomainLaminin G-like 2
TgeneLAMA4chr6:111803953chr6:112466135ENST0000052200617391234_1402777.33333333333341817.0DomainLaminin G-like 3
TgeneLAMA4chr6:111803953chr6:112466135ENST0000052200617391469_1640777.33333333333341817.0DomainLaminin G-like 4
TgeneLAMA4chr6:111803953chr6:112466135ENST0000052200617391647_1820777.33333333333341817.0DomainLaminin G-like 5
TgeneLAMA4chr6:111803953chr6:112466135ENST000005220061739833_1035777.33333333333341817.0DomainLaminin G-like 1
TgeneLAMA4chr6:111803953chr6:112466135ENST0000036863802724_7260121.0MotifCell attachment site
TgeneLAMA4chr6:111803953chr6:112466135ENST0000045393702724_7260121.0MotifCell attachment site
TgeneLAMA4chr6:111803953chr6:112466135ENST0000036863802256_8320121.0RegionNote=Domain II and I
TgeneLAMA4chr6:111803953chr6:112466135ENST0000045393702256_8320121.0RegionNote=Domain II and I

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneREV3Lchr6:111803953chr6:112466135ENST00000358835-2333086_310446.3333333333333363131.0MotifNote=CysB motif
HgeneREV3Lchr6:111803953chr6:112466135ENST00000368802-1323086_310446.3333333333333363131.0MotifNote=CysB motif
HgeneREV3Lchr6:111803953chr6:112466135ENST00000368805-2333086_310446.3333333333333363131.0MotifNote=CysB motif
HgeneREV3Lchr6:111803953chr6:112466135ENST00000435970-2343086_310403053.0MotifNote=CysB motif
HgeneREV3Lchr6:111803953chr6:112466135ENST00000358835-2333042_305746.3333333333333363131.0Zinc fingerNote=CysA-type
HgeneREV3Lchr6:111803953chr6:112466135ENST00000368802-1323042_305746.3333333333333363131.0Zinc fingerNote=CysA-type
HgeneREV3Lchr6:111803953chr6:112466135ENST00000368805-2333042_305746.3333333333333363131.0Zinc fingerNote=CysA-type
HgeneREV3Lchr6:111803953chr6:112466135ENST00000435970-2343042_305703053.0Zinc fingerNote=CysA-type
TgeneLAMA4chr6:111803953chr6:112466135ENST000002305381739320_403784.33333333333341824.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST000002305381739473_528784.33333333333341824.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST000002305381739581_614784.33333333333341824.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST000002305381739662_724784.33333333333341824.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST000002305381739777_806784.33333333333341824.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST000003894631739320_403777.33333333333341817.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST000003894631739473_528777.33333333333341817.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST000003894631739581_614777.33333333333341817.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST000003894631739662_724777.33333333333341817.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST000004244081638320_403777.33333333333341817.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST000004244081638473_528777.33333333333341817.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST000004244081638581_614777.33333333333341817.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST000004244081638662_724777.33333333333341817.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST000005220061739320_403777.33333333333341817.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST000005220061739473_528777.33333333333341817.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST000005220061739581_614777.33333333333341817.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST000005220061739662_724777.33333333333341817.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA4chr6:111803953chr6:112466135ENST000002305381739132_186784.33333333333341824.0DomainLaminin EGF-like 2
TgeneLAMA4chr6:111803953chr6:112466135ENST000002305381739187_240784.33333333333341824.0DomainLaminin EGF-like 3
TgeneLAMA4chr6:111803953chr6:112466135ENST000002305381739241_255784.33333333333341824.0DomainLaminin EGF-like 4%3B truncated
TgeneLAMA4chr6:111803953chr6:112466135ENST00000230538173982_131784.33333333333341824.0DomainLaminin EGF-like 1
TgeneLAMA4chr6:111803953chr6:112466135ENST000003894631739132_186777.33333333333341817.0DomainLaminin EGF-like 2
TgeneLAMA4chr6:111803953chr6:112466135ENST000003894631739187_240777.33333333333341817.0DomainLaminin EGF-like 3
TgeneLAMA4chr6:111803953chr6:112466135ENST000003894631739241_255777.33333333333341817.0DomainLaminin EGF-like 4%3B truncated
TgeneLAMA4chr6:111803953chr6:112466135ENST00000389463173982_131777.33333333333341817.0DomainLaminin EGF-like 1
TgeneLAMA4chr6:111803953chr6:112466135ENST000004244081638132_186777.33333333333341817.0DomainLaminin EGF-like 2
TgeneLAMA4chr6:111803953chr6:112466135ENST000004244081638187_240777.33333333333341817.0DomainLaminin EGF-like 3
TgeneLAMA4chr6:111803953chr6:112466135ENST000004244081638241_255777.33333333333341817.0DomainLaminin EGF-like 4%3B truncated
TgeneLAMA4chr6:111803953chr6:112466135ENST00000424408163882_131777.33333333333341817.0DomainLaminin EGF-like 1
TgeneLAMA4chr6:111803953chr6:112466135ENST000005220061739132_186777.33333333333341817.0DomainLaminin EGF-like 2
TgeneLAMA4chr6:111803953chr6:112466135ENST000005220061739187_240777.33333333333341817.0DomainLaminin EGF-like 3
TgeneLAMA4chr6:111803953chr6:112466135ENST000005220061739241_255777.33333333333341817.0DomainLaminin EGF-like 4%3B truncated
TgeneLAMA4chr6:111803953chr6:112466135ENST00000522006173982_131777.33333333333341817.0DomainLaminin EGF-like 1
TgeneLAMA4chr6:111803953chr6:112466135ENST000002305381739724_726784.33333333333341824.0MotifCell attachment site
TgeneLAMA4chr6:111803953chr6:112466135ENST000003894631739724_726777.33333333333341817.0MotifCell attachment site
TgeneLAMA4chr6:111803953chr6:112466135ENST000004244081638724_726777.33333333333341817.0MotifCell attachment site
TgeneLAMA4chr6:111803953chr6:112466135ENST000005220061739724_726777.33333333333341817.0MotifCell attachment site
TgeneLAMA4chr6:111803953chr6:112466135ENST000002305381739256_832784.33333333333341824.0RegionNote=Domain II and I
TgeneLAMA4chr6:111803953chr6:112466135ENST000003894631739256_832777.33333333333341817.0RegionNote=Domain II and I
TgeneLAMA4chr6:111803953chr6:112466135ENST000004244081638256_832777.33333333333341817.0RegionNote=Domain II and I
TgeneLAMA4chr6:111803953chr6:112466135ENST000005220061739256_832777.33333333333341817.0RegionNote=Domain II and I


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1856_REV3L_111803953_LAMA4_112466135_ranked_0.pdbREV3L111803953111803953ENST00000424408LAMA4chr6112466135-
MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAVRNLTEVVPQLLDQLRTVEQKRPASNVSASIQRIRELIAQTRSV
ASKIQVSMMFDGQSAVEVHSRTSMDDLKAFTSLSLYMKPPVKRPELTETADQFILYLGSKNAKKEYMGLAIKNDNLVYVYNLGTKDVEIP
LDSKPVSSWPAYFSIVKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFKLPTSLNLPGFVGCLEL
ATLNNDVISLYNFKHIYNMDPSTSVPCARDKLAFTQSRAASYFFDGSGYAVVRDITRRGKFGQVTRFDIEVRTPADNGLILLMVNGSMFF
RLEMRNGYLHVFYDFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVVDRRHVKSMDNEKMKIPFTDIYIGGAPPEILQSRAL
RAHLPLDINFRGCMKGFQFQKKDFNLLEQTETLGVGYGCPEDSLISRRAYFNGQSFIASIQKISFFDGFEGGFNFRTLQPNGLLFYYASG
SDVFSISLDNGTVIMDVKGIKVQSVDKQYNDGLSHFVISSVSPTRYELIVDKSRVGSKNPTKGKIEQTQASEKKFYFGGSPISAQYANFT
GCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLHKKGKNLSKPKASQNKKGGKSKDAPSWDPVALKLPERNTPRNSHCH
LSNSPRAIEHAYQYGGTANSRQEFEHLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQEKY
NDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGKAVKNVQINSIYSFSGCLSNLQLNGASITSASQTFSVT
PCFEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSVNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCD
GRWHRITVIRDSNVVQLDVDSEVNHVVGPLNPKPIDHREPVFVGGVPESLLTPRLAPSKPFTGCIRHFVIDGHPVSFSKAALVSGAVSIN
1085


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
REV3L_pLDDT.png
all structure
all structure
LAMA4_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
REV3L
LAMA4all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to REV3L-LAMA4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to REV3L-LAMA4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLAMA4C0000786Spontaneous abortion1CTD_human
TgeneLAMA4C0000822Abortion, Tubal1CTD_human
TgeneLAMA4C0340427Familial dilated cardiomyopathy1ORPHANET
TgeneLAMA4C3808935CARDIOMYOPATHY, DILATED, 1JJ1CTD_human;UNIPROT
TgeneLAMA4C3830362Early Pregnancy Loss1CTD_human
TgeneLAMA4C4552766Miscarriage1CTD_human