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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:RFWD2-DDR2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RFWD2-DDR2
FusionPDB ID: 73669
FusionGDB2.0 ID: 73669
HgeneTgene
Gene symbol

RFWD2

DDR2

Gene ID

64326

4921

Gene nameCOP1 E3 ubiquitin ligasediscoidin domain receptor tyrosine kinase 2
SynonymsCFAP78|FAP78|RFWD2|RNF200MIG20a|NTRKR3|TKT|TYRO10|WRCN
Cytomap

1q25.1-q25.2

1q23.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase COP1E3 ubiquitin-protein ligase RFWD2RING finger protein 200RING-type E3 ubiquitin transferase RFWD2constitutive photomorphogenesis protein 1 homologconstitutive photomorphogenic protein 1putative ubiquitin ligase COP1ridiscoidin domain-containing receptor 2CD167 antigen-like family member Bcell migration-inducing protein 20discoidin domain receptor 2discoidin domain receptor family, member 2discoidin domain-containing receptor tyrosine kinase 2hydroxyaryl-protein
Modification date2020031320200313
UniProtAcc.

Q16832

Ensembl transtripts involved in fusion geneENST idsENST00000308769, ENST00000367669, 
ENST00000367921, ENST00000367922, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 15 X 10=25509 X 8 X 6=432
# samples 2011
** MAII scorelog2(20/2550*10)=-3.6724253419715
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/432*10)=-1.97352778863881
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RFWD2 [Title/Abstract] AND DDR2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RFWD2(175996708)-DDR2(162722885), # samples:1
Anticipated loss of major functional domain due to fusion event.RFWD2-DDR2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RFWD2-DDR2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RFWD2-DDR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RFWD2-DDR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRFWD2

GO:0010212

response to ionizing radiation

19805145

TgeneDDR2

GO:0018108

peptidyl-tyrosine phosphorylation

20004161

TgeneDDR2

GO:0038063

collagen-activated tyrosine kinase receptor signaling pathway

16186108

TgeneDDR2

GO:0046777

protein autophosphorylation

16186108


check buttonFusion gene breakpoints across RFWD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DDR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-BF-AAP4-01ARFWD2chr1

175996708

-DDR2chr1

162722885

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367669RFWD2chr1175996708-ENST00000367922DDR2chr1162722885+11884224451547291404
ENST00000367669RFWD2chr1175996708-ENST00000367921DDR2chr1162722885+4905224451547291404
ENST00000308769RFWD2chr1175996708-ENST00000367922DDR2chr1162722885+112971657041421380
ENST00000308769RFWD2chr1175996708-ENST00000367921DDR2chr1162722885+43181657041421380

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367669ENST00000367922RFWD2chr1175996708-DDR2chr1162722885+0.0003286450.99967134
ENST00000367669ENST00000367921RFWD2chr1175996708-DDR2chr1162722885+0.0018155530.9981844
ENST00000308769ENST00000367922RFWD2chr1175996708-DDR2chr1162722885+0.0001841440.9998159
ENST00000308769ENST00000367921RFWD2chr1175996708-DDR2chr1162722885+0.0012402080.99875975

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>73669_73669_1_RFWD2-DDR2_RFWD2_chr1_175996708_ENST00000308769_DDR2_chr1_162722885_ENST00000367921_length(amino acids)=1380AA_BP=552
MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGGLGGPVRPVLVAPAVSGSGGGAVSTGLSRHS
CAARPSAGVGGSSSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI
DHLYPNFLVNELILKQKQRFEEKRFKLDHSNGHRWQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKVARRN
KREEMSGLYSPVSEDSTVPQFEAPSPSHSSIIDSTEYSQPPGFSGSSQTKKQPWYNSTLASRRKRLTAHFEDLEQCYFSTRMSRISDDSR
TASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVDIHYPENEMTCNSKIS
CISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFS
PSSRYHLAFGCAAICRYPLGMSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGR
HAGGHGIEFAPMYKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLDGLVSYN
APAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMK
VHCNNMFAKGVKIFKEVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSE
ALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQ
GSNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAV
EEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCI
TDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNL
YSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVY

--------------------------------------------------------------

>73669_73669_2_RFWD2-DDR2_RFWD2_chr1_175996708_ENST00000308769_DDR2_chr1_162722885_ENST00000367922_length(amino acids)=1380AA_BP=552
MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGGLGGPVRPVLVAPAVSGSGGGAVSTGLSRHS
CAARPSAGVGGSSSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI
DHLYPNFLVNELILKQKQRFEEKRFKLDHSNGHRWQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKVARRN
KREEMSGLYSPVSEDSTVPQFEAPSPSHSSIIDSTEYSQPPGFSGSSQTKKQPWYNSTLASRRKRLTAHFEDLEQCYFSTRMSRISDDSR
TASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVDIHYPENEMTCNSKIS
CISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFS
PSSRYHLAFGCAAICRYPLGMSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGR
HAGGHGIEFAPMYKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLDGLVSYN
APAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMK
VHCNNMFAKGVKIFKEVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSE
ALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQ
GSNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAV
EEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCI
TDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNL
YSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVY

--------------------------------------------------------------

>73669_73669_3_RFWD2-DDR2_RFWD2_chr1_175996708_ENST00000367669_DDR2_chr1_162722885_ENST00000367921_length(amino acids)=1404AA_BP=576
MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGGLGGPVRPVLVAPAVSGSGGGAVSTGLSRHS
CAARPSAGVGGSSSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI
DHLYPNFLVNELILKQKQRFEEKRFKLDHSVSSTNGHRWQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKV
ARRNKREQLEQIQKELSVLEEDIKRVEEMSGLYSPVSEDSTVPQFEAPSPSHSSIIDSTEYSQPPGFSGSSQTKKQPWYNSTLASRRKRL
TAHFEDLEQCYFSTRMSRISDDSRTASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEY
DTVIQDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKL
WSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCAAICRYPLGMSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPD
DLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTD
HSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRN
ESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYH
FADTWMMFSEITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEM
TVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQG
VTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARND
FLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDL
ATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENT

--------------------------------------------------------------

>73669_73669_4_RFWD2-DDR2_RFWD2_chr1_175996708_ENST00000367669_DDR2_chr1_162722885_ENST00000367922_length(amino acids)=1404AA_BP=576
MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGGLGGPVRPVLVAPAVSGSGGGAVSTGLSRHS
CAARPSAGVGGSSSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI
DHLYPNFLVNELILKQKQRFEEKRFKLDHSVSSTNGHRWQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKV
ARRNKREQLEQIQKELSVLEEDIKRVEEMSGLYSPVSEDSTVPQFEAPSPSHSSIIDSTEYSQPPGFSGSSQTKKQPWYNSTLASRRKRL
TAHFEDLEQCYFSTRMSRISDDSRTASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEY
DTVIQDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKL
WSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCAAICRYPLGMSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPD
DLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTD
HSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRN
ESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYH
FADTWMMFSEITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEM
TVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQG
VTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARND
FLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDL
ATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENT

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:175996708/chr1:162722885)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DDR2

Q16832

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Tyrosine kinase involved in the regulation of tissues remodeling (PubMed:30449416). It functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. {ECO:0000269|PubMed:16186104, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:17665456, ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20004161, ECO:0000269|PubMed:20564243, ECO:0000269|PubMed:20734453, ECO:0000269|PubMed:30449416, ECO:0000269|PubMed:9659899}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRFWD2chr1:175996708chr1:162722885ENST00000308769-1419233_301552.3333333333334708.0Coiled coilOntology_term=ECO:0000255
HgeneRFWD2chr1:175996708chr1:162722885ENST00000367669-1520233_301576.3333333333334732.0Coiled coilOntology_term=ECO:0000255
HgeneRFWD2chr1:175996708chr1:162722885ENST00000308769-14192_110552.3333333333334708.0Compositional biasNote=Ser-rich
HgeneRFWD2chr1:175996708chr1:162722885ENST00000367669-15202_110576.3333333333334732.0Compositional biasNote=Ser-rich
HgeneRFWD2chr1:175996708chr1:162722885ENST00000308769-1419109_113552.3333333333334708.0MotifNote=Nuclear localization signal 1
HgeneRFWD2chr1:175996708chr1:162722885ENST00000308769-1419195_206552.3333333333334708.0MotifNote=Nuclear localization signal 2
HgeneRFWD2chr1:175996708chr1:162722885ENST00000308769-1419235_245552.3333333333334708.0MotifNuclear export signal
HgeneRFWD2chr1:175996708chr1:162722885ENST00000367669-1520109_113576.3333333333334732.0MotifNote=Nuclear localization signal 1
HgeneRFWD2chr1:175996708chr1:162722885ENST00000367669-1520195_206576.3333333333334732.0MotifNote=Nuclear localization signal 2
HgeneRFWD2chr1:175996708chr1:162722885ENST00000367669-1520235_245576.3333333333334732.0MotifNuclear export signal
HgeneRFWD2chr1:175996708chr1:162722885ENST00000308769-1419419_458552.3333333333334708.0RepeatNote=WD 1
HgeneRFWD2chr1:175996708chr1:162722885ENST00000308769-1419468_508552.3333333333334708.0RepeatNote=WD 2
HgeneRFWD2chr1:175996708chr1:162722885ENST00000308769-1419511_551552.3333333333334708.0RepeatNote=WD 3
HgeneRFWD2chr1:175996708chr1:162722885ENST00000367669-1520419_458576.3333333333334732.0RepeatNote=WD 1
HgeneRFWD2chr1:175996708chr1:162722885ENST00000367669-1520468_508576.3333333333334732.0RepeatNote=WD 2
HgeneRFWD2chr1:175996708chr1:162722885ENST00000367669-1520511_551576.3333333333334732.0RepeatNote=WD 3
HgeneRFWD2chr1:175996708chr1:162722885ENST00000308769-1419136_174552.3333333333334708.0Zinc fingerRING-type
HgeneRFWD2chr1:175996708chr1:162722885ENST00000367669-1520136_174576.3333333333334732.0Zinc fingerRING-type
TgeneDDR2chr1:175996708chr1:162722885ENST00000367921218563_84927.333333333333332856.0DomainProtein kinase
TgeneDDR2chr1:175996708chr1:162722885ENST00000367922319563_84927.333333333333332856.0DomainProtein kinase
TgeneDDR2chr1:175996708chr1:162722885ENST00000367921218569_57727.333333333333332856.0Nucleotide bindingATP
TgeneDDR2chr1:175996708chr1:162722885ENST00000367922319569_57727.333333333333332856.0Nucleotide bindingATP
TgeneDDR2chr1:175996708chr1:162722885ENST00000367921218422_85527.333333333333332856.0Topological domainCytoplasmic
TgeneDDR2chr1:175996708chr1:162722885ENST00000367922319422_85527.333333333333332856.0Topological domainCytoplasmic
TgeneDDR2chr1:175996708chr1:162722885ENST00000367921218400_42127.333333333333332856.0TransmembraneHelical
TgeneDDR2chr1:175996708chr1:162722885ENST00000367922319400_42127.333333333333332856.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRFWD2chr1:175996708chr1:162722885ENST00000308769-1419553_593552.3333333333334708.0RepeatNote=WD 4
HgeneRFWD2chr1:175996708chr1:162722885ENST00000308769-1419597_635552.3333333333334708.0RepeatNote=WD 5
HgeneRFWD2chr1:175996708chr1:162722885ENST00000308769-1419638_677552.3333333333334708.0RepeatNote=WD 6
HgeneRFWD2chr1:175996708chr1:162722885ENST00000308769-1419691_729552.3333333333334708.0RepeatNote=WD 7
HgeneRFWD2chr1:175996708chr1:162722885ENST00000367669-1520553_593576.3333333333334732.0RepeatNote=WD 4
HgeneRFWD2chr1:175996708chr1:162722885ENST00000367669-1520597_635576.3333333333334732.0RepeatNote=WD 5
HgeneRFWD2chr1:175996708chr1:162722885ENST00000367669-1520638_677576.3333333333334732.0RepeatNote=WD 6
HgeneRFWD2chr1:175996708chr1:162722885ENST00000367669-1520691_729576.3333333333334732.0RepeatNote=WD 7
TgeneDDR2chr1:175996708chr1:162722885ENST0000036792121822_39927.333333333333332856.0Topological domainExtracellular
TgeneDDR2chr1:175996708chr1:162722885ENST0000036792231922_39927.333333333333332856.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RFWD2
DDR2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRFWD2chr1:175996708chr1:162722885ENST00000308769-1419643_645552.3333333333334708.0TRIB1
HgeneRFWD2chr1:175996708chr1:162722885ENST00000367669-1520643_645576.3333333333334732.0TRIB1


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Related Drugs to RFWD2-DDR2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RFWD2-DDR2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource