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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:RFWD2-KIF14

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RFWD2-KIF14
FusionPDB ID: 73674
FusionGDB2.0 ID: 73674
HgeneTgene
Gene symbol

RFWD2

KIF14

Gene ID

64326

9928

Gene nameCOP1 E3 ubiquitin ligasekinesin family member 14
SynonymsCFAP78|FAP78|RFWD2|RNF200MCPH20|MKS12
Cytomap

1q25.1-q25.2

1q32.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase COP1E3 ubiquitin-protein ligase RFWD2RING finger protein 200RING-type E3 ubiquitin transferase RFWD2constitutive photomorphogenesis protein 1 homologconstitutive photomorphogenic protein 1putative ubiquitin ligase COP1rikinesin-like protein KIF14epididymis secretory sperm binding protein
Modification date2020031320200315
UniProtAcc.

Q15058

Ensembl transtripts involved in fusion geneENST idsENST00000308769, ENST00000367669, 
ENST00000367350, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 15 X 10=25503 X 3 X 3=27
# samples 204
** MAII scorelog2(20/2550*10)=-3.6724253419715
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RFWD2 [Title/Abstract] AND KIF14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RFWD2(176118142)-KIF14(200578056), # samples:3
Anticipated loss of major functional domain due to fusion event.RFWD2-KIF14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RFWD2-KIF14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RFWD2-KIF14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RFWD2-KIF14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRFWD2

GO:0010212

response to ionizing radiation

19805145

TgeneKIF14

GO:0008284

positive regulation of cell proliferation

24784001

TgeneKIF14

GO:0034446

substrate adhesion-dependent cell spreading

23209302

TgeneKIF14

GO:0045184

establishment of protein localization

23209302


check buttonFusion gene breakpoints across RFWD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KIF14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A203-01ARFWD2chr1

176118142

-KIF14chr1

200578056

-
ChimerDB4BRCATCGA-BH-A203RFWD2chr1

176118141

-KIF14chr1

200578056

-
ChimerDB4BRCATCGA-BH-A203RFWD2chr1

176132004

-KIF14chr1

200578056

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367669RFWD2chr1176118142-ENST00000367350KIF14chr1200578056-6726134651548371440
ENST00000308769RFWD2chr1176118142-ENST00000367350KIF14chr1200578056-6199819043101436
ENST00000367669RFWD2chr1176118141-ENST00000367350KIF14chr1200578056-6726134651548371440
ENST00000308769RFWD2chr1176118141-ENST00000367350KIF14chr1200578056-6199819043101436
ENST00000367669RFWD2chr1176132004-ENST00000367350KIF14chr1200578056-6657127751547681417
ENST00000308769RFWD2chr1176132004-ENST00000367350KIF14chr1200578056-6130750042411413

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367669ENST00000367350RFWD2chr1176118142-KIF14chr1200578056-0.0002400480.99976
ENST00000308769ENST00000367350RFWD2chr1176118142-KIF14chr1200578056-0.0001428010.9998572
ENST00000367669ENST00000367350RFWD2chr1176118141-KIF14chr1200578056-0.0002400480.99976
ENST00000308769ENST00000367350RFWD2chr1176118141-KIF14chr1200578056-0.0001428010.9998572
ENST00000367669ENST00000367350RFWD2chr1176132004-KIF14chr1200578056-0.0002315140.99976844
ENST00000308769ENST00000367350RFWD2chr1176132004-KIF14chr1200578056-0.000136740.99986327

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>73674_73674_1_RFWD2-KIF14_RFWD2_chr1_176118141_ENST00000308769_KIF14_chr1_200578056_ENST00000367350_length(amino acids)=1436AA_BP=273
MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGGLGGPVRPVLVAPAVSGSGGGAVSTGLSRHS
CAARPSAGVGGSSSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI
DHLYPNFLVNELILKQKQRFEEKRFKLDHSNGHRWQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKVARRN
KREVSYHIEMSFFEVYNEKIHDLLVCKDENGQRKQPLRVREHPVYGPYVEALSMNIVSSYADIQSWLELGNKQRATAATGMNDKSSRSHS
VFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCSTAHTNGDRLKEGVSINKSLLTLGKVISALSEQANQRSVFIPYRESVLTWLL
KESLGGNSKTAMIATISPAASNIEETLSTLRYANQARLIVNIAKVNEDMNAKLIRELKAEIAKLKAAQRNSRNIDPERYRLCRQEITSLR
MKLHQQERDMAEMQRVWKEKFEQAEKRKLQETKELQKAGIMFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGTTTVGKYKPNSSHDIQLSG
VLIADDHCTIKNFGGTVSIIPVGEAKTYVNGKHILEITVLRHGDRVILGGDHYFRFNHPVEVQKGKRPSGRDTPISEGPKDFEFAKNELL
MAQRSQLEAEIKEAQLKAKEEMMQGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHKIEELEKAKQHLEQEI
YVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRNNRDKTFTVQTTWSSMKLSMMIQEANAISSKLKTYYVFGR
HDISDKSSSDTSIRVRNLKLGISTFWSLEKFESKLAAMKELYESNGSNRGEDAFCDPEDEWEPDITDAPVSSLSRRRSRSLMKNRRISGC
LHDIQVHPIKNLHSSHSSGLMDKSSTIYSNSAESFLPGICKELIGSSLDFFGQSYDEERTIADSLINSFLKIYNGLFAISKAHEEQDEES
QDNLFSSDRAIQSLTIQTACAFEQLVVLMKHWLSDLLPCTNIARLEDELRQEVKKLGGYLQLFLQGCCLDISSMIKEAQKNAIQIVQQAV
KYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAVCDGVGLGMKILLDSGLEKAKELQHELFRQCTKNEVTKEMKTNAMGLIRSLENIFA
ESKIKSFRRQVQEENFEYQDFKRMVNRAPEFLKLKHCLEKAIEIIISALKGCHSDINLLQTCVESIRNLASDFYSDFSVPSTSVGSYESR

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>73674_73674_2_RFWD2-KIF14_RFWD2_chr1_176118141_ENST00000367669_KIF14_chr1_200578056_ENST00000367350_length(amino acids)=1440AA_BP=277
MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGGLGGPVRPVLVAPAVSGSGGGAVSTGLSRHS
CAARPSAGVGGSSSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI
DHLYPNFLVNELILKQKQRFEEKRFKLDHSVSSTNGHRWQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKV
ARRNKREVSYHIEMSFFEVYNEKIHDLLVCKDENGQRKQPLRVREHPVYGPYVEALSMNIVSSYADIQSWLELGNKQRATAATGMNDKSS
RSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCSTAHTNGDRLKEGVSINKSLLTLGKVISALSEQANQRSVFIPYRESVL
TWLLKESLGGNSKTAMIATISPAASNIEETLSTLRYANQARLIVNIAKVNEDMNAKLIRELKAEIAKLKAAQRNSRNIDPERYRLCRQEI
TSLRMKLHQQERDMAEMQRVWKEKFEQAEKRKLQETKELQKAGIMFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGTTTVGKYKPNSSHDI
QLSGVLIADDHCTIKNFGGTVSIIPVGEAKTYVNGKHILEITVLRHGDRVILGGDHYFRFNHPVEVQKGKRPSGRDTPISEGPKDFEFAK
NELLMAQRSQLEAEIKEAQLKAKEEMMQGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHKIEELEKAKQHL
EQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRNNRDKTFTVQTTWSSMKLSMMIQEANAISSKLKTYY
VFGRHDISDKSSSDTSIRVRNLKLGISTFWSLEKFESKLAAMKELYESNGSNRGEDAFCDPEDEWEPDITDAPVSSLSRRRSRSLMKNRR
ISGCLHDIQVHPIKNLHSSHSSGLMDKSSTIYSNSAESFLPGICKELIGSSLDFFGQSYDEERTIADSLINSFLKIYNGLFAISKAHEEQ
DEESQDNLFSSDRAIQSLTIQTACAFEQLVVLMKHWLSDLLPCTNIARLEDELRQEVKKLGGYLQLFLQGCCLDISSMIKEAQKNAIQIV
QQAVKYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAVCDGVGLGMKILLDSGLEKAKELQHELFRQCTKNEVTKEMKTNAMGLIRSLE
NIFAESKIKSFRRQVQEENFEYQDFKRMVNRAPEFLKLKHCLEKAIEIIISALKGCHSDINLLQTCVESIRNLASDFYSDFSVPSTSVGS
YESRVTHIVHQELESLAKSLLFCFESEESPDLLKPWETYNQNTKEEHQQSKSSGIDGSKNKGVPKRVYELHGSSPAVSSEECTPSRIQWV

--------------------------------------------------------------

>73674_73674_3_RFWD2-KIF14_RFWD2_chr1_176118142_ENST00000308769_KIF14_chr1_200578056_ENST00000367350_length(amino acids)=1436AA_BP=273
MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGGLGGPVRPVLVAPAVSGSGGGAVSTGLSRHS
CAARPSAGVGGSSSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI
DHLYPNFLVNELILKQKQRFEEKRFKLDHSNGHRWQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKVARRN
KREVSYHIEMSFFEVYNEKIHDLLVCKDENGQRKQPLRVREHPVYGPYVEALSMNIVSSYADIQSWLELGNKQRATAATGMNDKSSRSHS
VFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCSTAHTNGDRLKEGVSINKSLLTLGKVISALSEQANQRSVFIPYRESVLTWLL
KESLGGNSKTAMIATISPAASNIEETLSTLRYANQARLIVNIAKVNEDMNAKLIRELKAEIAKLKAAQRNSRNIDPERYRLCRQEITSLR
MKLHQQERDMAEMQRVWKEKFEQAEKRKLQETKELQKAGIMFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGTTTVGKYKPNSSHDIQLSG
VLIADDHCTIKNFGGTVSIIPVGEAKTYVNGKHILEITVLRHGDRVILGGDHYFRFNHPVEVQKGKRPSGRDTPISEGPKDFEFAKNELL
MAQRSQLEAEIKEAQLKAKEEMMQGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHKIEELEKAKQHLEQEI
YVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRNNRDKTFTVQTTWSSMKLSMMIQEANAISSKLKTYYVFGR
HDISDKSSSDTSIRVRNLKLGISTFWSLEKFESKLAAMKELYESNGSNRGEDAFCDPEDEWEPDITDAPVSSLSRRRSRSLMKNRRISGC
LHDIQVHPIKNLHSSHSSGLMDKSSTIYSNSAESFLPGICKELIGSSLDFFGQSYDEERTIADSLINSFLKIYNGLFAISKAHEEQDEES
QDNLFSSDRAIQSLTIQTACAFEQLVVLMKHWLSDLLPCTNIARLEDELRQEVKKLGGYLQLFLQGCCLDISSMIKEAQKNAIQIVQQAV
KYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAVCDGVGLGMKILLDSGLEKAKELQHELFRQCTKNEVTKEMKTNAMGLIRSLENIFA
ESKIKSFRRQVQEENFEYQDFKRMVNRAPEFLKLKHCLEKAIEIIISALKGCHSDINLLQTCVESIRNLASDFYSDFSVPSTSVGSYESR

--------------------------------------------------------------

>73674_73674_4_RFWD2-KIF14_RFWD2_chr1_176118142_ENST00000367669_KIF14_chr1_200578056_ENST00000367350_length(amino acids)=1440AA_BP=277
MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGGLGGPVRPVLVAPAVSGSGGGAVSTGLSRHS
CAARPSAGVGGSSSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI
DHLYPNFLVNELILKQKQRFEEKRFKLDHSVSSTNGHRWQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKV
ARRNKREVSYHIEMSFFEVYNEKIHDLLVCKDENGQRKQPLRVREHPVYGPYVEALSMNIVSSYADIQSWLELGNKQRATAATGMNDKSS
RSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCSTAHTNGDRLKEGVSINKSLLTLGKVISALSEQANQRSVFIPYRESVL
TWLLKESLGGNSKTAMIATISPAASNIEETLSTLRYANQARLIVNIAKVNEDMNAKLIRELKAEIAKLKAAQRNSRNIDPERYRLCRQEI
TSLRMKLHQQERDMAEMQRVWKEKFEQAEKRKLQETKELQKAGIMFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGTTTVGKYKPNSSHDI
QLSGVLIADDHCTIKNFGGTVSIIPVGEAKTYVNGKHILEITVLRHGDRVILGGDHYFRFNHPVEVQKGKRPSGRDTPISEGPKDFEFAK
NELLMAQRSQLEAEIKEAQLKAKEEMMQGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHKIEELEKAKQHL
EQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRNNRDKTFTVQTTWSSMKLSMMIQEANAISSKLKTYY
VFGRHDISDKSSSDTSIRVRNLKLGISTFWSLEKFESKLAAMKELYESNGSNRGEDAFCDPEDEWEPDITDAPVSSLSRRRSRSLMKNRR
ISGCLHDIQVHPIKNLHSSHSSGLMDKSSTIYSNSAESFLPGICKELIGSSLDFFGQSYDEERTIADSLINSFLKIYNGLFAISKAHEEQ
DEESQDNLFSSDRAIQSLTIQTACAFEQLVVLMKHWLSDLLPCTNIARLEDELRQEVKKLGGYLQLFLQGCCLDISSMIKEAQKNAIQIV
QQAVKYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAVCDGVGLGMKILLDSGLEKAKELQHELFRQCTKNEVTKEMKTNAMGLIRSLE
NIFAESKIKSFRRQVQEENFEYQDFKRMVNRAPEFLKLKHCLEKAIEIIISALKGCHSDINLLQTCVESIRNLASDFYSDFSVPSTSVGS
YESRVTHIVHQELESLAKSLLFCFESEESPDLLKPWETYNQNTKEEHQQSKSSGIDGSKNKGVPKRVYELHGSSPAVSSEECTPSRIQWV

--------------------------------------------------------------

>73674_73674_5_RFWD2-KIF14_RFWD2_chr1_176132004_ENST00000308769_KIF14_chr1_200578056_ENST00000367350_length(amino acids)=1413AA_BP=250
MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGGLGGPVRPVLVAPAVSGSGGGAVSTGLSRHS
CAARPSAGVGGSSSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI
DHLYPNFLVNELILKQKQRFEEKRFKLDHSNGHRWQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAVSYHIEMSFFEVYNEKIHDL
LVCKDENGQRKQPLRVREHPVYGPYVEALSMNIVSSYADIQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRI
TSRINLIDLAGSERCSTAHTNGDRLKEGVSINKSLLTLGKVISALSEQANQRSVFIPYRESVLTWLLKESLGGNSKTAMIATISPAASNI
EETLSTLRYANQARLIVNIAKVNEDMNAKLIRELKAEIAKLKAAQRNSRNIDPERYRLCRQEITSLRMKLHQQERDMAEMQRVWKEKFEQ
AEKRKLQETKELQKAGIMFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGTTTVGKYKPNSSHDIQLSGVLIADDHCTIKNFGGTVSIIPVG
EAKTYVNGKHILEITVLRHGDRVILGGDHYFRFNHPVEVQKGKRPSGRDTPISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHKIEELEKAKQHLEQEIYVNKKRLEMETLATKQALEDHSI
RHARILEALETEKQKIAKEVQILQQNRNNRDKTFTVQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDISDKSSSDTSIRVRNLKLGIS
TFWSLEKFESKLAAMKELYESNGSNRGEDAFCDPEDEWEPDITDAPVSSLSRRRSRSLMKNRRISGCLHDIQVHPIKNLHSSHSSGLMDK
SSTIYSNSAESFLPGICKELIGSSLDFFGQSYDEERTIADSLINSFLKIYNGLFAISKAHEEQDEESQDNLFSSDRAIQSLTIQTACAFE
QLVVLMKHWLSDLLPCTNIARLEDELRQEVKKLGGYLQLFLQGCCLDISSMIKEAQKNAIQIVQQAVKYVGQLAVLKGSKLHFLENGNNK
AASVQEEFMDAVCDGVGLGMKILLDSGLEKAKELQHELFRQCTKNEVTKEMKTNAMGLIRSLENIFAESKIKSFRRQVQEENFEYQDFKR
MVNRAPEFLKLKHCLEKAIEIIISALKGCHSDINLLQTCVESIRNLASDFYSDFSVPSTSVGSYESRVTHIVHQELESLAKSLLFCFESE

--------------------------------------------------------------

>73674_73674_6_RFWD2-KIF14_RFWD2_chr1_176132004_ENST00000367669_KIF14_chr1_200578056_ENST00000367350_length(amino acids)=1417AA_BP=254
MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGGLGGPVRPVLVAPAVSGSGGGAVSTGLSRHS
CAARPSAGVGGSSSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI
DHLYPNFLVNELILKQKQRFEEKRFKLDHSVSSTNGHRWQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAVSYHIEMSFFEVYNEK
IHDLLVCKDENGQRKQPLRVREHPVYGPYVEALSMNIVSSYADIQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEH
DHRITSRINLIDLAGSERCSTAHTNGDRLKEGVSINKSLLTLGKVISALSEQANQRSVFIPYRESVLTWLLKESLGGNSKTAMIATISPA
ASNIEETLSTLRYANQARLIVNIAKVNEDMNAKLIRELKAEIAKLKAAQRNSRNIDPERYRLCRQEITSLRMKLHQQERDMAEMQRVWKE
KFEQAEKRKLQETKELQKAGIMFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGTTTVGKYKPNSSHDIQLSGVLIADDHCTIKNFGGTVSI
IPVGEAKTYVNGKHILEITVLRHGDRVILGGDHYFRFNHPVEVQKGKRPSGRDTPISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAK
EEMMQGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHKIEELEKAKQHLEQEIYVNKKRLEMETLATKQALE
DHSIRHARILEALETEKQKIAKEVQILQQNRNNRDKTFTVQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDISDKSSSDTSIRVRNLK
LGISTFWSLEKFESKLAAMKELYESNGSNRGEDAFCDPEDEWEPDITDAPVSSLSRRRSRSLMKNRRISGCLHDIQVHPIKNLHSSHSSG
LMDKSSTIYSNSAESFLPGICKELIGSSLDFFGQSYDEERTIADSLINSFLKIYNGLFAISKAHEEQDEESQDNLFSSDRAIQSLTIQTA
CAFEQLVVLMKHWLSDLLPCTNIARLEDELRQEVKKLGGYLQLFLQGCCLDISSMIKEAQKNAIQIVQQAVKYVGQLAVLKGSKLHFLEN
GNNKAASVQEEFMDAVCDGVGLGMKILLDSGLEKAKELQHELFRQCTKNEVTKEMKTNAMGLIRSLENIFAESKIKSFRRQVQEENFEYQ
DFKRMVNRAPEFLKLKHCLEKAIEIIISALKGCHSDINLLQTCVESIRNLASDFYSDFSVPSTSVGSYESRVTHIVHQELESLAKSLLFC

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:176118142/chr1:200578056)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KIF14

Q15058

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:24784001, PubMed:16648480). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRFWD2chr1:176118141chr1:200578056ENST00000308769-6192_110273.0708.0Compositional biasNote=Ser-rich
HgeneRFWD2chr1:176118141chr1:200578056ENST00000367669-6202_110277.0732.0Compositional biasNote=Ser-rich
HgeneRFWD2chr1:176118142chr1:200578056ENST00000308769-6192_110273.0708.0Compositional biasNote=Ser-rich
HgeneRFWD2chr1:176118142chr1:200578056ENST00000367669-6202_110277.0732.0Compositional biasNote=Ser-rich
HgeneRFWD2chr1:176132004chr1:200578056ENST00000308769-5192_110250.0708.0Compositional biasNote=Ser-rich
HgeneRFWD2chr1:176132004chr1:200578056ENST00000367669-5202_110254.0732.0Compositional biasNote=Ser-rich
HgeneRFWD2chr1:176118141chr1:200578056ENST00000308769-619109_113273.0708.0MotifNote=Nuclear localization signal 1
HgeneRFWD2chr1:176118141chr1:200578056ENST00000308769-619195_206273.0708.0MotifNote=Nuclear localization signal 2
HgeneRFWD2chr1:176118141chr1:200578056ENST00000308769-619235_245273.0708.0MotifNuclear export signal
HgeneRFWD2chr1:176118141chr1:200578056ENST00000367669-620109_113277.0732.0MotifNote=Nuclear localization signal 1
HgeneRFWD2chr1:176118141chr1:200578056ENST00000367669-620195_206277.0732.0MotifNote=Nuclear localization signal 2
HgeneRFWD2chr1:176118141chr1:200578056ENST00000367669-620235_245277.0732.0MotifNuclear export signal
HgeneRFWD2chr1:176118142chr1:200578056ENST00000308769-619109_113273.0708.0MotifNote=Nuclear localization signal 1
HgeneRFWD2chr1:176118142chr1:200578056ENST00000308769-619195_206273.0708.0MotifNote=Nuclear localization signal 2
HgeneRFWD2chr1:176118142chr1:200578056ENST00000308769-619235_245273.0708.0MotifNuclear export signal
HgeneRFWD2chr1:176118142chr1:200578056ENST00000367669-620109_113277.0732.0MotifNote=Nuclear localization signal 1
HgeneRFWD2chr1:176118142chr1:200578056ENST00000367669-620195_206277.0732.0MotifNote=Nuclear localization signal 2
HgeneRFWD2chr1:176118142chr1:200578056ENST00000367669-620235_245277.0732.0MotifNuclear export signal
HgeneRFWD2chr1:176132004chr1:200578056ENST00000308769-519109_113250.0708.0MotifNote=Nuclear localization signal 1
HgeneRFWD2chr1:176132004chr1:200578056ENST00000308769-519195_206250.0708.0MotifNote=Nuclear localization signal 2
HgeneRFWD2chr1:176132004chr1:200578056ENST00000308769-519235_245250.0708.0MotifNuclear export signal
HgeneRFWD2chr1:176132004chr1:200578056ENST00000367669-520109_113254.0732.0MotifNote=Nuclear localization signal 1
HgeneRFWD2chr1:176132004chr1:200578056ENST00000367669-520195_206254.0732.0MotifNote=Nuclear localization signal 2
HgeneRFWD2chr1:176132004chr1:200578056ENST00000367669-520235_245254.0732.0MotifNuclear export signal
HgeneRFWD2chr1:176118141chr1:200578056ENST00000308769-619136_174273.0708.0Zinc fingerRING-type
HgeneRFWD2chr1:176118141chr1:200578056ENST00000367669-620136_174277.0732.0Zinc fingerRING-type
HgeneRFWD2chr1:176118142chr1:200578056ENST00000308769-619136_174273.0708.0Zinc fingerRING-type
HgeneRFWD2chr1:176118142chr1:200578056ENST00000367669-620136_174277.0732.0Zinc fingerRING-type
HgeneRFWD2chr1:176132004chr1:200578056ENST00000308769-519136_174250.0708.0Zinc fingerRING-type
HgeneRFWD2chr1:176132004chr1:200578056ENST00000367669-520136_174254.0732.0Zinc fingerRING-type
TgeneKIF14chr1:176118141chr1:200578056ENST000003673503301332_1348485.01649.0Coiled coilOntology_term=ECO:0000255
TgeneKIF14chr1:176118141chr1:200578056ENST000003673503301468_1500485.01649.0Coiled coilOntology_term=ECO:0000255
TgeneKIF14chr1:176118141chr1:200578056ENST00000367350330705_791485.01649.0Coiled coilOntology_term=ECO:0000255
TgeneKIF14chr1:176118141chr1:200578056ENST00000367350330922_1079485.01649.0Coiled coilOntology_term=ECO:0000255
TgeneKIF14chr1:176118142chr1:200578056ENST000003673503301332_1348485.01649.0Coiled coilOntology_term=ECO:0000255
TgeneKIF14chr1:176118142chr1:200578056ENST000003673503301468_1500485.01649.0Coiled coilOntology_term=ECO:0000255
TgeneKIF14chr1:176118142chr1:200578056ENST00000367350330705_791485.01649.0Coiled coilOntology_term=ECO:0000255
TgeneKIF14chr1:176118142chr1:200578056ENST00000367350330922_1079485.01649.0Coiled coilOntology_term=ECO:0000255
TgeneKIF14chr1:176132004chr1:200578056ENST000003673503301332_1348485.01649.0Coiled coilOntology_term=ECO:0000255
TgeneKIF14chr1:176132004chr1:200578056ENST000003673503301468_1500485.01649.0Coiled coilOntology_term=ECO:0000255
TgeneKIF14chr1:176132004chr1:200578056ENST00000367350330705_791485.01649.0Coiled coilOntology_term=ECO:0000255
TgeneKIF14chr1:176132004chr1:200578056ENST00000367350330922_1079485.01649.0Coiled coilOntology_term=ECO:0000255
TgeneKIF14chr1:176118141chr1:200578056ENST00000367350330825_891485.01649.0DomainNote=FHA
TgeneKIF14chr1:176118142chr1:200578056ENST00000367350330825_891485.01649.0DomainNote=FHA
TgeneKIF14chr1:176132004chr1:200578056ENST00000367350330825_891485.01649.0DomainNote=FHA
TgeneKIF14chr1:176118141chr1:200578056ENST00000367350330901_1648485.01649.0RegionNote=Required for CIT-binding
TgeneKIF14chr1:176118142chr1:200578056ENST00000367350330901_1648485.01649.0RegionNote=Required for CIT-binding
TgeneKIF14chr1:176132004chr1:200578056ENST00000367350330901_1648485.01649.0RegionNote=Required for CIT-binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRFWD2chr1:176118141chr1:200578056ENST00000308769-619233_301273.0708.0Coiled coilOntology_term=ECO:0000255
HgeneRFWD2chr1:176118141chr1:200578056ENST00000367669-620233_301277.0732.0Coiled coilOntology_term=ECO:0000255
HgeneRFWD2chr1:176118142chr1:200578056ENST00000308769-619233_301273.0708.0Coiled coilOntology_term=ECO:0000255
HgeneRFWD2chr1:176118142chr1:200578056ENST00000367669-620233_301277.0732.0Coiled coilOntology_term=ECO:0000255
HgeneRFWD2chr1:176132004chr1:200578056ENST00000308769-519233_301250.0708.0Coiled coilOntology_term=ECO:0000255
HgeneRFWD2chr1:176132004chr1:200578056ENST00000367669-520233_301254.0732.0Coiled coilOntology_term=ECO:0000255
HgeneRFWD2chr1:176118141chr1:200578056ENST00000308769-619419_458273.0708.0RepeatNote=WD 1
HgeneRFWD2chr1:176118141chr1:200578056ENST00000308769-619468_508273.0708.0RepeatNote=WD 2
HgeneRFWD2chr1:176118141chr1:200578056ENST00000308769-619511_551273.0708.0RepeatNote=WD 3
HgeneRFWD2chr1:176118141chr1:200578056ENST00000308769-619553_593273.0708.0RepeatNote=WD 4
HgeneRFWD2chr1:176118141chr1:200578056ENST00000308769-619597_635273.0708.0RepeatNote=WD 5
HgeneRFWD2chr1:176118141chr1:200578056ENST00000308769-619638_677273.0708.0RepeatNote=WD 6
HgeneRFWD2chr1:176118141chr1:200578056ENST00000308769-619691_729273.0708.0RepeatNote=WD 7
HgeneRFWD2chr1:176118141chr1:200578056ENST00000367669-620419_458277.0732.0RepeatNote=WD 1
HgeneRFWD2chr1:176118141chr1:200578056ENST00000367669-620468_508277.0732.0RepeatNote=WD 2
HgeneRFWD2chr1:176118141chr1:200578056ENST00000367669-620511_551277.0732.0RepeatNote=WD 3
HgeneRFWD2chr1:176118141chr1:200578056ENST00000367669-620553_593277.0732.0RepeatNote=WD 4
HgeneRFWD2chr1:176118141chr1:200578056ENST00000367669-620597_635277.0732.0RepeatNote=WD 5
HgeneRFWD2chr1:176118141chr1:200578056ENST00000367669-620638_677277.0732.0RepeatNote=WD 6
HgeneRFWD2chr1:176118141chr1:200578056ENST00000367669-620691_729277.0732.0RepeatNote=WD 7
HgeneRFWD2chr1:176118142chr1:200578056ENST00000308769-619419_458273.0708.0RepeatNote=WD 1
HgeneRFWD2chr1:176118142chr1:200578056ENST00000308769-619468_508273.0708.0RepeatNote=WD 2
HgeneRFWD2chr1:176118142chr1:200578056ENST00000308769-619511_551273.0708.0RepeatNote=WD 3
HgeneRFWD2chr1:176118142chr1:200578056ENST00000308769-619553_593273.0708.0RepeatNote=WD 4
HgeneRFWD2chr1:176118142chr1:200578056ENST00000308769-619597_635273.0708.0RepeatNote=WD 5
HgeneRFWD2chr1:176118142chr1:200578056ENST00000308769-619638_677273.0708.0RepeatNote=WD 6
HgeneRFWD2chr1:176118142chr1:200578056ENST00000308769-619691_729273.0708.0RepeatNote=WD 7
HgeneRFWD2chr1:176118142chr1:200578056ENST00000367669-620419_458277.0732.0RepeatNote=WD 1
HgeneRFWD2chr1:176118142chr1:200578056ENST00000367669-620468_508277.0732.0RepeatNote=WD 2
HgeneRFWD2chr1:176118142chr1:200578056ENST00000367669-620511_551277.0732.0RepeatNote=WD 3
HgeneRFWD2chr1:176118142chr1:200578056ENST00000367669-620553_593277.0732.0RepeatNote=WD 4
HgeneRFWD2chr1:176118142chr1:200578056ENST00000367669-620597_635277.0732.0RepeatNote=WD 5
HgeneRFWD2chr1:176118142chr1:200578056ENST00000367669-620638_677277.0732.0RepeatNote=WD 6
HgeneRFWD2chr1:176118142chr1:200578056ENST00000367669-620691_729277.0732.0RepeatNote=WD 7
HgeneRFWD2chr1:176132004chr1:200578056ENST00000308769-519419_458250.0708.0RepeatNote=WD 1
HgeneRFWD2chr1:176132004chr1:200578056ENST00000308769-519468_508250.0708.0RepeatNote=WD 2
HgeneRFWD2chr1:176132004chr1:200578056ENST00000308769-519511_551250.0708.0RepeatNote=WD 3
HgeneRFWD2chr1:176132004chr1:200578056ENST00000308769-519553_593250.0708.0RepeatNote=WD 4
HgeneRFWD2chr1:176132004chr1:200578056ENST00000308769-519597_635250.0708.0RepeatNote=WD 5
HgeneRFWD2chr1:176132004chr1:200578056ENST00000308769-519638_677250.0708.0RepeatNote=WD 6
HgeneRFWD2chr1:176132004chr1:200578056ENST00000308769-519691_729250.0708.0RepeatNote=WD 7
HgeneRFWD2chr1:176132004chr1:200578056ENST00000367669-520419_458254.0732.0RepeatNote=WD 1
HgeneRFWD2chr1:176132004chr1:200578056ENST00000367669-520468_508254.0732.0RepeatNote=WD 2
HgeneRFWD2chr1:176132004chr1:200578056ENST00000367669-520511_551254.0732.0RepeatNote=WD 3
HgeneRFWD2chr1:176132004chr1:200578056ENST00000367669-520553_593254.0732.0RepeatNote=WD 4
HgeneRFWD2chr1:176132004chr1:200578056ENST00000367669-520597_635254.0732.0RepeatNote=WD 5
HgeneRFWD2chr1:176132004chr1:200578056ENST00000367669-520638_677254.0732.0RepeatNote=WD 6
HgeneRFWD2chr1:176132004chr1:200578056ENST00000367669-520691_729254.0732.0RepeatNote=WD 7
TgeneKIF14chr1:176118141chr1:200578056ENST00000367350330358_701485.01649.0DomainKinesin motor
TgeneKIF14chr1:176118142chr1:200578056ENST00000367350330358_701485.01649.0DomainKinesin motor
TgeneKIF14chr1:176132004chr1:200578056ENST00000367350330358_701485.01649.0DomainKinesin motor
TgeneKIF14chr1:176118141chr1:200578056ENST00000367350330447_454485.01649.0Nucleotide bindingATP
TgeneKIF14chr1:176118142chr1:200578056ENST00000367350330447_454485.01649.0Nucleotide bindingATP
TgeneKIF14chr1:176132004chr1:200578056ENST00000367350330447_454485.01649.0Nucleotide bindingATP
TgeneKIF14chr1:176118141chr1:200578056ENST000003673503301_356485.01649.0RegionNote=Required for PRC1-binding
TgeneKIF14chr1:176118141chr1:200578056ENST00000367350330356_737485.01649.0RegionRequired for microtubule-binding with high affinity
TgeneKIF14chr1:176118142chr1:200578056ENST000003673503301_356485.01649.0RegionNote=Required for PRC1-binding
TgeneKIF14chr1:176118142chr1:200578056ENST00000367350330356_737485.01649.0RegionRequired for microtubule-binding with high affinity
TgeneKIF14chr1:176132004chr1:200578056ENST000003673503301_356485.01649.0RegionNote=Required for PRC1-binding
TgeneKIF14chr1:176132004chr1:200578056ENST00000367350330356_737485.01649.0RegionRequired for microtubule-binding with high affinity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RFWD2
KIF14


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRFWD2chr1:176118141chr1:200578056ENST00000308769-619643_645273.0708.0TRIB1
HgeneRFWD2chr1:176118141chr1:200578056ENST00000367669-620643_645277.0732.0TRIB1
HgeneRFWD2chr1:176118142chr1:200578056ENST00000308769-619643_645273.0708.0TRIB1
HgeneRFWD2chr1:176118142chr1:200578056ENST00000367669-620643_645277.0732.0TRIB1
HgeneRFWD2chr1:176132004chr1:200578056ENST00000308769-519643_645250.0708.0TRIB1
HgeneRFWD2chr1:176132004chr1:200578056ENST00000367669-520643_645254.0732.0TRIB1


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Related Drugs to RFWD2-KIF14


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RFWD2-KIF14


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource