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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ATF2-CHRNA1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ATF2-CHRNA1
FusionPDB ID: 7409
FusionGDB2.0 ID: 7409
HgeneTgene
Gene symbol

ATF2

CHRNA1

Gene ID

2668

1134

Gene nameglial cell derived neurotrophic factorcholinergic receptor nicotinic alpha 1 subunit
SynonymsATF|ATF1|ATF2|HFB1-GDNF|HSCR3ACHRA|ACHRD|CHRNA|CMS1A|CMS1B|CMS2A|FCCMS|SCCMS
Cytomap

5p13.2

2q31.1

Type of geneprotein-codingprotein-coding
Descriptionglial cell line-derived neurotrophic factorastrocyte-derived trophic factoracetylcholine receptor subunit alphaacetylcholine receptor, nicotinic, alpha 1 (muscle)cholinergic receptor, nicotinic alpha 1cholinergic receptor, nicotinic, alpha 1 (muscle)cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)muscle nicotin
Modification date2020031420200313
UniProtAcc

P15336

.
Ensembl transtripts involved in fusion geneENST idsENST00000487334, ENST00000538946, 
ENST00000392544, ENST00000409437, 
ENST00000426833, ENST00000264110, 
ENST00000345739, ENST00000392543, 
ENST00000409499, ENST00000409635, 
ENST00000409833, ENST00000413123, 
ENST00000261007, ENST00000348749, 
ENST00000409219, ENST00000409323, 
ENST00000409542, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 11 X 9=11884 X 3 X 3=36
# samples 134
** MAII scorelog2(13/1188*10)=-3.19195130777231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ATF2 [Title/Abstract] AND CHRNA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ATF2(175945388)-CHRNA1(175624361), # samples:1
Anticipated loss of major functional domain due to fusion event.ATF2-CHRNA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATF2-CHRNA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATF2-CHRNA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATF2-CHRNA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATF2-CHRNA1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ATF2-CHRNA1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ATF2-CHRNA1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ATF2-CHRNA1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATF2

GO:0001755

neural crest cell migration

15242795

HgeneATF2

GO:0008284

positive regulation of cell proliferation

22897442

HgeneATF2

GO:0031175

neuron projection development

15242795

HgeneATF2

GO:0032770

positive regulation of monooxygenase activity

12358785

HgeneATF2

GO:0043524

negative regulation of neuron apoptotic process

8493557

HgeneATF2

GO:0045944

positive regulation of transcription by RNA polymerase II

12358785

HgeneATF2

GO:0048255

mRNA stabilization

12358785

HgeneATF2

GO:0051584

regulation of dopamine uptake involved in synaptic transmission

8493557

HgeneATF2

GO:0072107

positive regulation of ureteric bud formation

8657307

HgeneATF2

GO:0090190

positive regulation of branching involved in ureteric bud morphogenesis

8657307|17229286

HgeneATF2

GO:2001240

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

10921886


check buttonFusion gene breakpoints across ATF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CHRNA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-85-8072-01AATF2chr2

175945388

-CHRNA1chr2

175624361

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000345739ATF2chr2175945388-ENST00000348749CHRNA1chr2175624361-335614933762823815
ENST00000345739ATF2chr2175945388-ENST00000261007CHRNA1chr2175624361-336314933762898840
ENST00000345739ATF2chr2175945388-ENST00000409219CHRNA1chr2175624361-289814933762583735
ENST00000345739ATF2chr2175945388-ENST00000409542CHRNA1chr2175624361-289214933762577733
ENST00000345739ATF2chr2175945388-ENST00000409323CHRNA1chr2175624361-297614933762259627
ENST00000264110ATF2chr2175945388-ENST00000348749CHRNA1chr2175624361-345315902992920873
ENST00000264110ATF2chr2175945388-ENST00000261007CHRNA1chr2175624361-346015902992995898
ENST00000264110ATF2chr2175945388-ENST00000409219CHRNA1chr2175624361-299515902992680793
ENST00000264110ATF2chr2175945388-ENST00000409542CHRNA1chr2175624361-298915902992674791
ENST00000264110ATF2chr2175945388-ENST00000409323CHRNA1chr2175624361-307315902992356685
ENST00000409635ATF2chr2175945388-ENST00000348749CHRNA1chr2175624361-341615534362883815
ENST00000409635ATF2chr2175945388-ENST00000261007CHRNA1chr2175624361-342315534362958840
ENST00000409635ATF2chr2175945388-ENST00000409219CHRNA1chr2175624361-295815534362643735
ENST00000409635ATF2chr2175945388-ENST00000409542CHRNA1chr2175624361-295215534362637733
ENST00000409635ATF2chr2175945388-ENST00000409323CHRNA1chr2175624361-303615534362319627
ENST00000392543ATF2chr2175945388-ENST00000348749CHRNA1chr2175624361-23334702621800512
ENST00000392543ATF2chr2175945388-ENST00000261007CHRNA1chr2175624361-23404702621875537
ENST00000392543ATF2chr2175945388-ENST00000409219CHRNA1chr2175624361-18754702621560432
ENST00000392543ATF2chr2175945388-ENST00000409542CHRNA1chr2175624361-18694702621554430
ENST00000392543ATF2chr2175945388-ENST00000409323CHRNA1chr2175624361-19534702621236324
ENST00000409499ATF2chr2175945388-ENST00000348749CHRNA1chr2175624361-23334702621800512
ENST00000409499ATF2chr2175945388-ENST00000261007CHRNA1chr2175624361-23404702621875537
ENST00000409499ATF2chr2175945388-ENST00000409219CHRNA1chr2175624361-18754702621560432
ENST00000409499ATF2chr2175945388-ENST00000409542CHRNA1chr2175624361-18694702621554430
ENST00000409499ATF2chr2175945388-ENST00000409323CHRNA1chr2175624361-19534702621236324

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000345739ENST00000348749ATF2chr2175945388-CHRNA1chr2175624361-0.001445090.9985549
ENST00000345739ENST00000261007ATF2chr2175945388-CHRNA1chr2175624361-0.0011804490.99881953
ENST00000345739ENST00000409219ATF2chr2175945388-CHRNA1chr2175624361-0.0026945390.9973054
ENST00000345739ENST00000409542ATF2chr2175945388-CHRNA1chr2175624361-0.0025497460.9974503
ENST00000345739ENST00000409323ATF2chr2175945388-CHRNA1chr2175624361-0.0031905660.9968094
ENST00000264110ENST00000348749ATF2chr2175945388-CHRNA1chr2175624361-0.0007808220.9992192
ENST00000264110ENST00000261007ATF2chr2175945388-CHRNA1chr2175624361-0.0006597440.99934024
ENST00000264110ENST00000409219ATF2chr2175945388-CHRNA1chr2175624361-0.0015373840.9984627
ENST00000264110ENST00000409542ATF2chr2175945388-CHRNA1chr2175624361-0.0016070160.998393
ENST00000264110ENST00000409323ATF2chr2175945388-CHRNA1chr2175624361-0.0029097980.9970902
ENST00000409635ENST00000348749ATF2chr2175945388-CHRNA1chr2175624361-0.0014331850.9985668
ENST00000409635ENST00000261007ATF2chr2175945388-CHRNA1chr2175624361-0.0011892930.99881077
ENST00000409635ENST00000409219ATF2chr2175945388-CHRNA1chr2175624361-0.0026550590.9973449
ENST00000409635ENST00000409542ATF2chr2175945388-CHRNA1chr2175624361-0.0025154760.99748445
ENST00000409635ENST00000409323ATF2chr2175945388-CHRNA1chr2175624361-0.0032100740.9967899
ENST00000392543ENST00000348749ATF2chr2175945388-CHRNA1chr2175624361-0.0012828970.99871707
ENST00000392543ENST00000261007ATF2chr2175945388-CHRNA1chr2175624361-0.0011400770.9988599
ENST00000392543ENST00000409219ATF2chr2175945388-CHRNA1chr2175624361-0.0018854320.9981146
ENST00000392543ENST00000409542ATF2chr2175945388-CHRNA1chr2175624361-0.0031739760.99682605
ENST00000392543ENST00000409323ATF2chr2175945388-CHRNA1chr2175624361-0.0013703210.9986297
ENST00000409499ENST00000348749ATF2chr2175945388-CHRNA1chr2175624361-0.0012828970.99871707
ENST00000409499ENST00000261007ATF2chr2175945388-CHRNA1chr2175624361-0.0011400770.9988599
ENST00000409499ENST00000409219ATF2chr2175945388-CHRNA1chr2175624361-0.0018854320.9981146
ENST00000409499ENST00000409542ATF2chr2175945388-CHRNA1chr2175624361-0.0031739760.99682605
ENST00000409499ENST00000409323ATF2chr2175945388-CHRNA1chr2175624361-0.0013703210.9986297

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>7409_7409_1_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000264110_CHRNA1_chr2_175624361_ENST00000261007_length(amino acids)=898AA_BP=0
MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELAS
PFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSD
SSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPV
QSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQSTSGRRRRAANEDPDEKRRKFLE
RNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTGLVLGSEHETRLVAKLFKD
YSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIH
IPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSN
FMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLV
IVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDIS

--------------------------------------------------------------

>7409_7409_2_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000264110_CHRNA1_chr2_175624361_ENST00000348749_length(amino acids)=873AA_BP=0
MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELAS
PFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSD
SSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPV
QSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQSTSGRRRRAANEDPDEKRRKFLE
RNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTGLVLGSEHETRLVAKLFKD
YSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVK
FTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCP
DTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVF
VIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKS

--------------------------------------------------------------

>7409_7409_3_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000264110_CHRNA1_chr2_175624361_ENST00000409219_length(amino acids)=793AA_BP=0
MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELAS
PFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSD
SSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPV
QSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQSTSGRRRRAANEDPDEKRRKFLE
RNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTGLVLGSEHETRLVAKLFKD
YSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVK
FTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCP
DTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVF

--------------------------------------------------------------

>7409_7409_4_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000264110_CHRNA1_chr2_175624361_ENST00000409323_length(amino acids)=685AA_BP=0
MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELAS
PFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSD
SSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPV
QSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQSTSGRRRRAANEDPDEKRRKFLE
RNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTGLVLGSEHETRLVAKLFKD
YSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVK
FTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCP

--------------------------------------------------------------

>7409_7409_5_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000264110_CHRNA1_chr2_175624361_ENST00000409542_length(amino acids)=791AA_BP=0
MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELAS
PFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSD
SSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPV
QSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQSTSGRRRRAANEDPDEKRRKFLE
RNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTGLVLGSEHETRLVAKLFKD
YSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKH
SVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGK
YMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPL

--------------------------------------------------------------

>7409_7409_6_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000345739_CHRNA1_chr2_175624361_ENST00000261007_length(amino acids)=840AA_BP=0
MYCAWMWPDQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDE
KEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSS
NVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATSTTETPAS
PAHTTPQTQSTSGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDC
PVTAMQKKSGYHTGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTL
GVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPF
DEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSF
LTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFI
DTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMD

--------------------------------------------------------------

>7409_7409_7_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000345739_CHRNA1_chr2_175624361_ENST00000348749_length(amino acids)=815AA_BP=0
MYCAWMWPDQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDE
KEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSS
NVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATSTTETPAS
PAHTTPQTQSTSGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDC
PVTAMQKKSGYHTGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDY
GGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPES
DQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLS
LTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIF
TEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIE

--------------------------------------------------------------

>7409_7409_8_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000345739_CHRNA1_chr2_175624361_ENST00000409219_length(amino acids)=735AA_BP=0
MYCAWMWPDQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDE
KEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSS
NVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATSTTETPAS
PAHTTPQTQSTSGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDC
PVTAMQKKSGYHTGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDY
GGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPES
DQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLS
LTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKAAAEWKYVAMVMDHILLGVFMLVCIIGT

--------------------------------------------------------------

>7409_7409_9_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000345739_CHRNA1_chr2_175624361_ENST00000409323_length(amino acids)=627AA_BP=0
MYCAWMWPDQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDE
KEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSS
NVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATSTTETPAS
PAHTTPQTQSTSGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDC
PVTAMQKKSGYHTGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDY
GGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPES

--------------------------------------------------------------

>7409_7409_10_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000345739_CHRNA1_chr2_175624361_ENST00000409542_length(amino acids)=733AA_BP=0
MYCAWMWPDQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDE
KEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSS
NVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATSTTETPAS
PAHTTPQTQSTSGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDC
PVTAMQKKSGYHTGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQNCSMKLGTWTYDGS
VVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMT
LSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSR
EKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLA

--------------------------------------------------------------

>7409_7409_11_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000392543_CHRNA1_chr2_175624361_ENST00000261007_length(amino acids)=537AA_BP=0
MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTGLVLGSEHETRLVAKLFKDY
SSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHI
PSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNF
MESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVI
VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISD

--------------------------------------------------------------

>7409_7409_12_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000392543_CHRNA1_chr2_175624361_ENST00000348749_length(amino acids)=512AA_BP=0
MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTGLVLGSEHETRLVAKLFKDY
SSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKF
TKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD
TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFV
IASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA

--------------------------------------------------------------

>7409_7409_13_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000392543_CHRNA1_chr2_175624361_ENST00000409219_length(amino acids)=432AA_BP=0
MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTGLVLGSEHETRLVAKLFKDY
SSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKF
TKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD
TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFV

--------------------------------------------------------------

>7409_7409_14_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000392543_CHRNA1_chr2_175624361_ENST00000409323_length(amino acids)=324AA_BP=0
MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTGLVLGSEHETRLVAKLFKDY
SSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKF
TKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD

--------------------------------------------------------------

>7409_7409_15_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000392543_CHRNA1_chr2_175624361_ENST00000409542_length(amino acids)=430AA_BP=0
MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTGLVLGSEHETRLVAKLFKDY
SSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHS
VTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKY
MLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLI

--------------------------------------------------------------

>7409_7409_16_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000409499_CHRNA1_chr2_175624361_ENST00000261007_length(amino acids)=537AA_BP=0
MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTGLVLGSEHETRLVAKLFKDY
SSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHI
PSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNF
MESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVI
VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISD

--------------------------------------------------------------

>7409_7409_17_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000409499_CHRNA1_chr2_175624361_ENST00000348749_length(amino acids)=512AA_BP=0
MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTGLVLGSEHETRLVAKLFKDY
SSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKF
TKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD
TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFV
IASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA

--------------------------------------------------------------

>7409_7409_18_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000409499_CHRNA1_chr2_175624361_ENST00000409219_length(amino acids)=432AA_BP=0
MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTGLVLGSEHETRLVAKLFKDY
SSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKF
TKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD
TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFV

--------------------------------------------------------------

>7409_7409_19_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000409499_CHRNA1_chr2_175624361_ENST00000409323_length(amino acids)=324AA_BP=0
MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTGLVLGSEHETRLVAKLFKDY
SSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKF
TKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD

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>7409_7409_20_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000409499_CHRNA1_chr2_175624361_ENST00000409542_length(amino acids)=430AA_BP=0
MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTGLVLGSEHETRLVAKLFKDY
SSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHS
VTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKY
MLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLI

--------------------------------------------------------------

>7409_7409_21_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000409635_CHRNA1_chr2_175624361_ENST00000261007_length(amino acids)=840AA_BP=0
MYCAWMWPDQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDE
KEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSS
NVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATSTTETPAS
PAHTTPQTQSTSGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDC
PVTAMQKKSGYHTGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTL
GVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPF
DEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSF
LTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFI
DTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMD

--------------------------------------------------------------

>7409_7409_22_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000409635_CHRNA1_chr2_175624361_ENST00000348749_length(amino acids)=815AA_BP=0
MYCAWMWPDQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDE
KEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSS
NVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATSTTETPAS
PAHTTPQTQSTSGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDC
PVTAMQKKSGYHTGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDY
GGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPES
DQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLS
LTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIF
TEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIE

--------------------------------------------------------------

>7409_7409_23_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000409635_CHRNA1_chr2_175624361_ENST00000409219_length(amino acids)=735AA_BP=0
MYCAWMWPDQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDE
KEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSS
NVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATSTTETPAS
PAHTTPQTQSTSGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDC
PVTAMQKKSGYHTGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDY
GGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPES
DQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLS
LTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKAAAEWKYVAMVMDHILLGVFMLVCIIGT

--------------------------------------------------------------

>7409_7409_24_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000409635_CHRNA1_chr2_175624361_ENST00000409323_length(amino acids)=627AA_BP=0
MYCAWMWPDQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDE
KEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSS
NVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATSTTETPAS
PAHTTPQTQSTSGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDC
PVTAMQKKSGYHTGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDY
GGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPES

--------------------------------------------------------------

>7409_7409_25_ATF2-CHRNA1_ATF2_chr2_175945388_ENST00000409635_CHRNA1_chr2_175624361_ENST00000409542_length(amino acids)=733AA_BP=0
MYCAWMWPDQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDE
KEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSS
NVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATSTTETPAS
PAHTTPQTQSTSGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDC
PVTAMQKKSGYHTGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQNCSMKLGTWTYDGS
VVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMT
LSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSR
EKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLA

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:175945388/chr2:175624361)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATF2

P15336

.
FUNCTION: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATF2chr2:175945388chr2:175624361ENST00000264110-1314352_415430.3333333333333506.0DomainbZIP
HgeneATF2chr2:175945388chr2:175624361ENST00000392544-1415352_415430.3333333333333506.0DomainbZIP
HgeneATF2chr2:175945388chr2:175624361ENST00000426833-1415352_415412.3333333333333488.0DomainbZIP
HgeneATF2chr2:175945388chr2:175624361ENST00000487334-1416352_415398.6666666666667373.3333333333333DomainbZIP
HgeneATF2chr2:175945388chr2:175624361ENST00000264110-13141_7430.3333333333333506.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175945388chr2:175624361ENST00000264110-1314405_414430.3333333333333506.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175945388chr2:175624361ENST00000345739-12131_7372.3333333333333448.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175945388chr2:175624361ENST00000392543-561_751.333333333333336127.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175945388chr2:175624361ENST00000392544-14151_7430.3333333333333506.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175945388chr2:175624361ENST00000392544-1415405_414430.3333333333333506.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175945388chr2:175624361ENST00000409499-561_769.33333333333333145.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175945388chr2:175624361ENST00000409635-13141_7372.3333333333333448.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175945388chr2:175624361ENST00000426833-14151_7412.3333333333333488.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175945388chr2:175624361ENST00000426833-1415405_414412.3333333333333488.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175945388chr2:175624361ENST00000487334-14161_7398.6666666666667373.3333333333333MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175945388chr2:175624361ENST00000487334-1416405_414398.6666666666667373.3333333333333MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175945388chr2:175624361ENST00000264110-1314296_299430.3333333333333506.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175945388chr2:175624361ENST00000264110-1314354_374430.3333333333333506.0RegionBasic motif
HgeneATF2chr2:175945388chr2:175624361ENST00000264110-1314380_408430.3333333333333506.0RegionLeucine-zipper
HgeneATF2chr2:175945388chr2:175624361ENST00000345739-1213296_299372.3333333333333448.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175945388chr2:175624361ENST00000345739-1213354_374372.3333333333333448.0RegionBasic motif
HgeneATF2chr2:175945388chr2:175624361ENST00000392544-1415296_299430.3333333333333506.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175945388chr2:175624361ENST00000392544-1415354_374430.3333333333333506.0RegionBasic motif
HgeneATF2chr2:175945388chr2:175624361ENST00000392544-1415380_408430.3333333333333506.0RegionLeucine-zipper
HgeneATF2chr2:175945388chr2:175624361ENST00000409635-1314296_299372.3333333333333448.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175945388chr2:175624361ENST00000409635-1314354_374372.3333333333333448.0RegionBasic motif
HgeneATF2chr2:175945388chr2:175624361ENST00000426833-1415296_299412.3333333333333488.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175945388chr2:175624361ENST00000426833-1415354_374412.3333333333333488.0RegionBasic motif
HgeneATF2chr2:175945388chr2:175624361ENST00000426833-1415380_408412.3333333333333488.0RegionLeucine-zipper
HgeneATF2chr2:175945388chr2:175624361ENST00000487334-1416296_299398.6666666666667373.3333333333333RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175945388chr2:175624361ENST00000487334-1416354_374398.6666666666667373.3333333333333RegionBasic motif
HgeneATF2chr2:175945388chr2:175624361ENST00000487334-1416380_408398.6666666666667373.3333333333333RegionLeucine-zipper
HgeneATF2chr2:175945388chr2:175624361ENST00000264110-131425_49430.3333333333333506.0Zinc fingerC2H2-type
HgeneATF2chr2:175945388chr2:175624361ENST00000345739-121325_49372.3333333333333448.0Zinc fingerC2H2-type
HgeneATF2chr2:175945388chr2:175624361ENST00000392543-5625_4951.333333333333336127.0Zinc fingerC2H2-type
HgeneATF2chr2:175945388chr2:175624361ENST00000392544-141525_49430.3333333333333506.0Zinc fingerC2H2-type
HgeneATF2chr2:175945388chr2:175624361ENST00000409499-5625_4969.33333333333333145.0Zinc fingerC2H2-type
HgeneATF2chr2:175945388chr2:175624361ENST00000409635-131425_49372.3333333333333448.0Zinc fingerC2H2-type
HgeneATF2chr2:175945388chr2:175624361ENST00000426833-141525_49412.3333333333333488.0Zinc fingerC2H2-type
HgeneATF2chr2:175945388chr2:175624361ENST00000487334-141625_49398.6666666666667373.3333333333333Zinc fingerC2H2-type
TgeneCHRNA1chr2:175945388chr2:175624361ENST0000026100701021_25514.333333333333334483.0Topological domainNote=Extracellular
TgeneCHRNA1chr2:175945388chr2:175624361ENST00000261007010342_45314.333333333333334483.0Topological domainNote=Cytoplasmic
TgeneCHRNA1chr2:175945388chr2:175624361ENST000003487490921_25514.333333333333334458.0Topological domainNote=Extracellular
TgeneCHRNA1chr2:175945388chr2:175624361ENST0000034874909342_45314.333333333333334458.0Topological domainNote=Cytoplasmic
TgeneCHRNA1chr2:175945388chr2:175624361ENST00000261007010256_28014.333333333333334483.0TransmembraneNote=Helical
TgeneCHRNA1chr2:175945388chr2:175624361ENST00000261007010288_30614.333333333333334483.0TransmembraneNote=Helical
TgeneCHRNA1chr2:175945388chr2:175624361ENST00000261007010322_34114.333333333333334483.0TransmembraneNote=Helical
TgeneCHRNA1chr2:175945388chr2:175624361ENST00000261007010454_47214.333333333333334483.0TransmembraneNote=Helical
TgeneCHRNA1chr2:175945388chr2:175624361ENST0000034874909256_28014.333333333333334458.0TransmembraneNote=Helical
TgeneCHRNA1chr2:175945388chr2:175624361ENST0000034874909288_30614.333333333333334458.0TransmembraneNote=Helical
TgeneCHRNA1chr2:175945388chr2:175624361ENST0000034874909322_34114.333333333333334458.0TransmembraneNote=Helical
TgeneCHRNA1chr2:175945388chr2:175624361ENST0000034874909454_47214.333333333333334458.0TransmembraneNote=Helical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATF2chr2:175945388chr2:175624361ENST00000345739-1213352_415372.3333333333333448.0DomainbZIP
HgeneATF2chr2:175945388chr2:175624361ENST00000392543-56352_41551.333333333333336127.0DomainbZIP
HgeneATF2chr2:175945388chr2:175624361ENST00000409499-56352_41569.33333333333333145.0DomainbZIP
HgeneATF2chr2:175945388chr2:175624361ENST00000409635-1314352_415372.3333333333333448.0DomainbZIP
HgeneATF2chr2:175945388chr2:175624361ENST00000409833-18352_4150210.0DomainbZIP
HgeneATF2chr2:175945388chr2:175624361ENST00000345739-1213405_414372.3333333333333448.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175945388chr2:175624361ENST00000392543-56405_41451.333333333333336127.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175945388chr2:175624361ENST00000409499-56405_41469.33333333333333145.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175945388chr2:175624361ENST00000409635-1314405_414372.3333333333333448.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175945388chr2:175624361ENST00000409833-181_70210.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175945388chr2:175624361ENST00000409833-18405_4140210.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175945388chr2:175624361ENST00000345739-1213380_408372.3333333333333448.0RegionLeucine-zipper
HgeneATF2chr2:175945388chr2:175624361ENST00000392543-56296_29951.333333333333336127.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175945388chr2:175624361ENST00000392543-56354_37451.333333333333336127.0RegionBasic motif
HgeneATF2chr2:175945388chr2:175624361ENST00000392543-56380_40851.333333333333336127.0RegionLeucine-zipper
HgeneATF2chr2:175945388chr2:175624361ENST00000409499-56296_29969.33333333333333145.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175945388chr2:175624361ENST00000409499-56354_37469.33333333333333145.0RegionBasic motif
HgeneATF2chr2:175945388chr2:175624361ENST00000409499-56380_40869.33333333333333145.0RegionLeucine-zipper
HgeneATF2chr2:175945388chr2:175624361ENST00000409635-1314380_408372.3333333333333448.0RegionLeucine-zipper
HgeneATF2chr2:175945388chr2:175624361ENST00000409833-18296_2990210.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175945388chr2:175624361ENST00000409833-18354_3740210.0RegionBasic motif
HgeneATF2chr2:175945388chr2:175624361ENST00000409833-18380_4080210.0RegionLeucine-zipper
HgeneATF2chr2:175945388chr2:175624361ENST00000409833-1825_490210.0Zinc fingerC2H2-type


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ATF2
CHRNA1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ATF2-CHRNA1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ATF2-CHRNA1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATF2C0006826Malignant Neoplasms1CTD_human
HgeneATF2C0027651Neoplasms1CTD_human
HgeneATF2C0086692Benign Neoplasm1CTD_human
HgeneATF2C0235874Disease Exacerbation1CTD_human