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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:RNF111-SLTM

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RNF111-SLTM
FusionPDB ID: 74699
FusionGDB2.0 ID: 74699
HgeneTgene
Gene symbol

RNF111

SLTM

Gene ID

54778

79811

Gene namering finger protein 111SAFB like transcription modulator
SynonymsARK|hRNF111Met
Cytomap

15q22.1-q22.2

15q22.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase ArkadiaArkadiaRING-type E3 ubiquitin transferase ArkadiaSAFB-like transcription modulatormodulator of estrogen-induced transcription
Modification date2020032720200313
UniProtAcc.

Q9NWH9

Ensembl transtripts involved in fusion geneENST idsENST00000348370, ENST00000434298, 
ENST00000557998, ENST00000559209, 
ENST00000561186, ENST00000560080, 
ENST00000536328, ENST00000557950, 
ENST00000380516, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 8 X 9=79212 X 15 X 5=900
# samples 1416
** MAII scorelog2(14/792*10)=-2.50007360313464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/900*10)=-2.49185309632967
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RNF111 [Title/Abstract] AND SLTM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RNF111(59359282)-SLTM(59193486), # samples:2
Anticipated loss of major functional domain due to fusion event.RNF111-SLTM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RNF111-SLTM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RNF111-SLTM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RNF111-SLTM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RNF111 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLTM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-ZF-A9RN-01ARNF111chr15

59359282

-SLTMchr15

59193486

-
ChimerDB4BLCATCGA-ZF-A9RNRNF111chr15

59359282

+SLTMchr15

59193486

-
ChimerDB4CESCTCGA-C5-A3HE-01ARNF111chr15

59323901

-SLTMchr15

59209198

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000348370RNF111chr1559359282+ENST00000380516SLTMchr1559193486-5617211943346621409
ENST00000434298RNF111chr1559359282+ENST00000380516SLTMchr1559193486-5606210842246511409
ENST00000559209RNF111chr1559359282+ENST00000380516SLTMchr1559193486-5320182213643651409
ENST00000557998RNF111chr1559359282+ENST00000380516SLTMchr1559193486-5471197328745161409
ENST00000561186RNF111chr1559359282+ENST00000380516SLTMchr1559193486-51841686042291409
ENST00000348370RNF111chr1559323901-ENST00000380516SLTMchr1559209198-5122131343341671244
ENST00000434298RNF111chr1559323901-ENST00000380516SLTMchr1559209198-5111130242241561244
ENST00000559209RNF111chr1559323901-ENST00000380516SLTMchr1559209198-4825101613638701244
ENST00000557998RNF111chr1559323901-ENST00000380516SLTMchr1559209198-4976116728740211244
ENST00000561186RNF111chr1559323901-ENST00000380516SLTMchr1559209198-4689880037341244

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000348370ENST00000380516RNF111chr1559359282+SLTMchr1559193486-0.0007688390.9992312
ENST00000434298ENST00000380516RNF111chr1559359282+SLTMchr1559193486-0.0007655240.99923444
ENST00000559209ENST00000380516RNF111chr1559359282+SLTMchr1559193486-0.0005269540.99947304
ENST00000557998ENST00000380516RNF111chr1559359282+SLTMchr1559193486-0.0006071670.99939287
ENST00000561186ENST00000380516RNF111chr1559359282+SLTMchr1559193486-0.0005303750.9994697
ENST00000348370ENST00000380516RNF111chr1559323901-SLTMchr1559209198-0.0003882870.9996118
ENST00000434298ENST00000380516RNF111chr1559323901-SLTMchr1559209198-0.0003859560.99961406
ENST00000559209ENST00000380516RNF111chr1559323901-SLTMchr1559209198-0.0002611020.9997389
ENST00000557998ENST00000380516RNF111chr1559323901-SLTMchr1559209198-0.0003015720.9996984
ENST00000561186ENST00000380516RNF111chr1559323901-SLTMchr1559209198-0.000265510.99973446

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>74699_74699_1_RNF111-SLTM_RNF111_chr15_59323901_ENST00000348370_SLTM_chr15_59209198_ENST00000380516_length(amino acids)=1244AA_BP=293
MSQWTPEYNELYTLKVDMKSEIPSDAPKTQESLKGILLHPEPIGAAKSFPAGVEMINSKVGNEFSHLCDDSQKQEKEMNGNQQEQEKSLV
VRKKRKSQQAGPSYVQNCVKENQGILGLRQHLGTPSDEDNDSSFSDCLSSPSSSLHFGDSDTVTSDEDKEVSVRHSQTILNAKSRSHSAR
SHKWPRTETESVSGLLMKRPCLHGSSLRRLPCRKRFVKNNSSQRTQKQKERILMQRKKREVLARRKYALLPSSSSSSENDLSSESSSSSS
TEGEEDLFVSASENHQNNPAVPSGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKR
AHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKDIAGSGDGTQEVSKPLPSEGSLAEADHTAHEEMEAHTTVKEAED
DNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKKAES
GDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNAR
SPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKS
EKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYR
RKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIR
IEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFP
ESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVIIHDRPDITHPRHP
REAGPNPSRPTSWKSEGSMSTDKRETRVERPERSGREVSGHSVRGAPPGNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRD

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>74699_74699_2_RNF111-SLTM_RNF111_chr15_59323901_ENST00000434298_SLTM_chr15_59209198_ENST00000380516_length(amino acids)=1244AA_BP=293
MSQWTPEYNELYTLKVDMKSEIPSDAPKTQESLKGILLHPEPIGAAKSFPAGVEMINSKVGNEFSHLCDDSQKQEKEMNGNQQEQEKSLV
VRKKRKSQQAGPSYVQNCVKENQGILGLRQHLGTPSDEDNDSSFSDCLSSPSSSLHFGDSDTVTSDEDKEVSVRHSQTILNAKSRSHSAR
SHKWPRTETESVSGLLMKRPCLHGSSLRRLPCRKRFVKNNSSQRTQKQKERILMQRKKREVLARRKYALLPSSSSSSENDLSSESSSSSS
TEGEEDLFVSASENHQNNPAVPSGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKR
AHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKDIAGSGDGTQEVSKPLPSEGSLAEADHTAHEEMEAHTTVKEAED
DNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKKAES
GDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNAR
SPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKS
EKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYR
RKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIR
IEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFP
ESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVIIHDRPDITHPRHP
REAGPNPSRPTSWKSEGSMSTDKRETRVERPERSGREVSGHSVRGAPPGNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRD

--------------------------------------------------------------

>74699_74699_3_RNF111-SLTM_RNF111_chr15_59323901_ENST00000557998_SLTM_chr15_59209198_ENST00000380516_length(amino acids)=1244AA_BP=293
MSQWTPEYNELYTLKVDMKSEIPSDAPKTQESLKGILLHPEPIGAAKSFPAGVEMINSKVGNEFSHLCDDSQKQEKEMNGNQQEQEKSLV
VRKKRKSQQAGPSYVQNCVKENQGILGLRQHLGTPSDEDNDSSFSDCLSSPSSSLHFGDSDTVTSDEDKEVSVRHSQTILNAKSRSHSAR
SHKWPRTETESVSGLLMKRPCLHGSSLRRLPCRKRFVKNNSSQRTQKQKERILMQRKKREVLARRKYALLPSSSSSSENDLSSESSSSSS
TEGEEDLFVSASENHQNNPAVPSGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKR
AHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKDIAGSGDGTQEVSKPLPSEGSLAEADHTAHEEMEAHTTVKEAED
DNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKKAES
GDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNAR
SPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKS
EKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYR
RKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIR
IEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFP
ESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVIIHDRPDITHPRHP
REAGPNPSRPTSWKSEGSMSTDKRETRVERPERSGREVSGHSVRGAPPGNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRD

--------------------------------------------------------------

>74699_74699_4_RNF111-SLTM_RNF111_chr15_59323901_ENST00000559209_SLTM_chr15_59209198_ENST00000380516_length(amino acids)=1244AA_BP=293
MSQWTPEYNELYTLKVDMKSEIPSDAPKTQESLKGILLHPEPIGAAKSFPAGVEMINSKVGNEFSHLCDDSQKQEKEMNGNQQEQEKSLV
VRKKRKSQQAGPSYVQNCVKENQGILGLRQHLGTPSDEDNDSSFSDCLSSPSSSLHFGDSDTVTSDEDKEVSVRHSQTILNAKSRSHSAR
SHKWPRTETESVSGLLMKRPCLHGSSLRRLPCRKRFVKNNSSQRTQKQKERILMQRKKREVLARRKYALLPSSSSSSENDLSSESSSSSS
TEGEEDLFVSASENHQNNPAVPSGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKR
AHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKDIAGSGDGTQEVSKPLPSEGSLAEADHTAHEEMEAHTTVKEAED
DNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKKAES
GDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNAR
SPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKS
EKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYR
RKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIR
IEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFP
ESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVIIHDRPDITHPRHP
REAGPNPSRPTSWKSEGSMSTDKRETRVERPERSGREVSGHSVRGAPPGNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRD

--------------------------------------------------------------

>74699_74699_5_RNF111-SLTM_RNF111_chr15_59323901_ENST00000561186_SLTM_chr15_59209198_ENST00000380516_length(amino acids)=1244AA_BP=293
MSQWTPEYNELYTLKVDMKSEIPSDAPKTQESLKGILLHPEPIGAAKSFPAGVEMINSKVGNEFSHLCDDSQKQEKEMNGNQQEQEKSLV
VRKKRKSQQAGPSYVQNCVKENQGILGLRQHLGTPSDEDNDSSFSDCLSSPSSSLHFGDSDTVTSDEDKEVSVRHSQTILNAKSRSHSAR
SHKWPRTETESVSGLLMKRPCLHGSSLRRLPCRKRFVKNNSSQRTQKQKERILMQRKKREVLARRKYALLPSSSSSSENDLSSESSSSSS
TEGEEDLFVSASENHQNNPAVPSGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKR
AHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKDIAGSGDGTQEVSKPLPSEGSLAEADHTAHEEMEAHTTVKEAED
DNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKKAES
GDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNAR
SPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKS
EKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYR
RKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIR
IEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFP
ESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVIIHDRPDITHPRHP
REAGPNPSRPTSWKSEGSMSTDKRETRVERPERSGREVSGHSVRGAPPGNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRD

--------------------------------------------------------------

>74699_74699_6_RNF111-SLTM_RNF111_chr15_59359282_ENST00000348370_SLTM_chr15_59193486_ENST00000380516_length(amino acids)=1409AA_BP=561
MSQWTPEYNELYTLKVDMKSEIPSDAPKTQESLKGILLHPEPIGAAKSFPAGVEMINSKVGNEFSHLCDDSQKQEKEMNGNQQEQEKSLV
VRKKRKSQQAGPSYVQNCVKENQGILGLRQHLGTPSDEDNDSSFSDCLSSPSSSLHFGDSDTVTSDEDKEVSVRHSQTILNAKSRSHSAR
SHKWPRTETESVSGLLMKRPCLHGSSLRRLPCRKRFVKNNSSQRTQKQKERILMQRKKREVLARRKYALLPSSSSSSENDLSSESSSSSS
TEGEEDLFVSASENHQNNPAVPSGSIDEDVVVIEASSTPQVTANEEINVTSTDSEVEIVTVGESYRSRSTLGHSRSHWSQGSSSHASRPQ
EPRNRSRISTVIQPLRQNAAEVVDLTVDEDEPTVVPTTSARMESQATSASINNSNPSTSEQASDTASAVTSSQPSTVSETSATLTSNSTT
GTSIGDDSRRTTSSAVTETGPPAMPRLPSCCPQHSPCGGSSQNHHALGHPHTSCFQQHGHHFQHHHHHHHTPHPAVPVSPSFSDPACPVE
RPPQVQAPCGANSSSGTSYHEQDGEEEENEKDIAGSGDGTQEVSKPLPSEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITL
DFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSST
GASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSS
TEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKD
EKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRL
REHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIARE
REELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDR
FVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKS
EGSMSTDKRETRVERPERSGREVSGHSVRGAPPGNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRDTSGPRKEWHGPPSQG

--------------------------------------------------------------

>74699_74699_7_RNF111-SLTM_RNF111_chr15_59359282_ENST00000434298_SLTM_chr15_59193486_ENST00000380516_length(amino acids)=1409AA_BP=561
MSQWTPEYNELYTLKVDMKSEIPSDAPKTQESLKGILLHPEPIGAAKSFPAGVEMINSKVGNEFSHLCDDSQKQEKEMNGNQQEQEKSLV
VRKKRKSQQAGPSYVQNCVKENQGILGLRQHLGTPSDEDNDSSFSDCLSSPSSSLHFGDSDTVTSDEDKEVSVRHSQTILNAKSRSHSAR
SHKWPRTETESVSGLLMKRPCLHGSSLRRLPCRKRFVKNNSSQRTQKQKERILMQRKKREVLARRKYALLPSSSSSSENDLSSESSSSSS
TEGEEDLFVSASENHQNNPAVPSGSIDEDVVVIEASSTPQVTANEEINVTSTDSEVEIVTVGESYRSRSTLGHSRSHWSQGSSSHASRPQ
EPRNRSRISTVIQPLRQNAAEVVDLTVDEDEPTVVPTTSARMESQATSASINNSNPSTSEQASDTASAVTSSQPSTVSETSATLTSNSTT
GTSIGDDSRRTTSSAVTETGPPAMPRLPSCCPQHSPCGGSSQNHHALGHPHTSCFQQHGHHFQHHHHHHHTPHPAVPVSPSFSDPACPVE
RPPQVQAPCGANSSSGTSYHEQDGEEEENEKDIAGSGDGTQEVSKPLPSEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITL
DFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSST
GASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSS
TEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKD
EKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRL
REHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIARE
REELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDR
FVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKS
EGSMSTDKRETRVERPERSGREVSGHSVRGAPPGNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRDTSGPRKEWHGPPSQG

--------------------------------------------------------------

>74699_74699_8_RNF111-SLTM_RNF111_chr15_59359282_ENST00000557998_SLTM_chr15_59193486_ENST00000380516_length(amino acids)=1409AA_BP=561
MSQWTPEYNELYTLKVDMKSEIPSDAPKTQESLKGILLHPEPIGAAKSFPAGVEMINSKVGNEFSHLCDDSQKQEKEMNGNQQEQEKSLV
VRKKRKSQQAGPSYVQNCVKENQGILGLRQHLGTPSDEDNDSSFSDCLSSPSSSLHFGDSDTVTSDEDKEVSVRHSQTILNAKSRSHSAR
SHKWPRTETESVSGLLMKRPCLHGSSLRRLPCRKRFVKNNSSQRTQKQKERILMQRKKREVLARRKYALLPSSSSSSENDLSSESSSSSS
TEGEEDLFVSASENHQNNPAVPSGSIDEDVVVIEASSTPQVTANEEINVTSTDSEVEIVTVGESYRSRSTLGHSRSHWSQGSSSHASRPQ
EPRNRSRISTVIQPLRQNAAEVVDLTVDEDEPTVVPTTSARMESQATSASINNSNPSTSEQASDTASAVTSSQPSTVSETSATLTSNSTT
GTSIGDDSRRTTSSAVTETGPPAMPRLPSCCPQHSPCGGSSQNHHALGHPHTSCFQQHGHHFQHHHHHHHTPHPAVPVSPSFSDPACPVE
RPPQVQAPCGANSSSGTSYHEQDGEEEENEKDIAGSGDGTQEVSKPLPSEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITL
DFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSST
GASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSS
TEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKD
EKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRL
REHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIARE
REELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDR
FVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKS
EGSMSTDKRETRVERPERSGREVSGHSVRGAPPGNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRDTSGPRKEWHGPPSQG

--------------------------------------------------------------

>74699_74699_9_RNF111-SLTM_RNF111_chr15_59359282_ENST00000559209_SLTM_chr15_59193486_ENST00000380516_length(amino acids)=1409AA_BP=561
MSQWTPEYNELYTLKVDMKSEIPSDAPKTQESLKGILLHPEPIGAAKSFPAGVEMINSKVGNEFSHLCDDSQKQEKEMNGNQQEQEKSLV
VRKKRKSQQAGPSYVQNCVKENQGILGLRQHLGTPSDEDNDSSFSDCLSSPSSSLHFGDSDTVTSDEDKEVSVRHSQTILNAKSRSHSAR
SHKWPRTETESVSGLLMKRPCLHGSSLRRLPCRKRFVKNNSSQRTQKQKERILMQRKKREVLARRKYALLPSSSSSSENDLSSESSSSSS
TEGEEDLFVSASENHQNNPAVPSGSIDEDVVVIEASSTPQVTANEEINVTSTDSEVEIVTVGESYRSRSTLGHSRSHWSQGSSSHASRPQ
EPRNRSRISTVIQPLRQNAAEVVDLTVDEDEPTVVPTTSARMESQATSASINNSNPSTSEQASDTASAVTSSQPSTVSETSATLTSNSTT
GTSIGDDSRRTTSSAVTETGPPAMPRLPSCCPQHSPCGGSSQNHHALGHPHTSCFQQHGHHFQHHHHHHHTPHPAVPVSPSFSDPACPVE
RPPQVQAPCGANSSSGTSYHEQDGEEEENEKDIAGSGDGTQEVSKPLPSEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITL
DFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSST
GASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSS
TEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKD
EKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRL
REHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIARE
REELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDR
FVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKS
EGSMSTDKRETRVERPERSGREVSGHSVRGAPPGNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRDTSGPRKEWHGPPSQG

--------------------------------------------------------------

>74699_74699_10_RNF111-SLTM_RNF111_chr15_59359282_ENST00000561186_SLTM_chr15_59193486_ENST00000380516_length(amino acids)=1409AA_BP=561
MSQWTPEYNELYTLKVDMKSEIPSDAPKTQESLKGILLHPEPIGAAKSFPAGVEMINSKVGNEFSHLCDDSQKQEKEMNGNQQEQEKSLV
VRKKRKSQQAGPSYVQNCVKENQGILGLRQHLGTPSDEDNDSSFSDCLSSPSSSLHFGDSDTVTSDEDKEVSVRHSQTILNAKSRSHSAR
SHKWPRTETESVSGLLMKRPCLHGSSLRRLPCRKRFVKNNSSQRTQKQKERILMQRKKREVLARRKYALLPSSSSSSENDLSSESSSSSS
TEGEEDLFVSASENHQNNPAVPSGSIDEDVVVIEASSTPQVTANEEINVTSTDSEVEIVTVGESYRSRSTLGHSRSHWSQGSSSHASRPQ
EPRNRSRISTVIQPLRQNAAEVVDLTVDEDEPTVVPTTSARMESQATSASINNSNPSTSEQASDTASAVTSSQPSTVSETSATLTSNSTT
GTSIGDDSRRTTSSAVTETGPPAMPRLPSCCPQHSPCGGSSQNHHALGHPHTSCFQQHGHHFQHHHHHHHTPHPAVPVSPSFSDPACPVE
RPPQVQAPCGANSSSGTSYHEQDGEEEENEKDIAGSGDGTQEVSKPLPSEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITL
DFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSST
GASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSS
TEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKD
EKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRL
REHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIARE
REELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDR
FVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKS
EGSMSTDKRETRVERPERSGREVSGHSVRGAPPGNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRDTSGPRKEWHGPPSQG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:59359282/chr15:59193486)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.SLTM

Q9NWH9

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF111chr15:59359282chr15:59193486ENST00000348370+614252_464562.0987.0Compositional biasNote=Ser-rich
HgeneRNF111chr15:59359282chr15:59193486ENST00000348370+614494_523562.0987.0Compositional biasNote=His-rich
HgeneRNF111chr15:59359282chr15:59193486ENST00000434298+614252_464562.01004.0Compositional biasNote=Ser-rich
HgeneRNF111chr15:59359282chr15:59193486ENST00000434298+614494_523562.01004.0Compositional biasNote=His-rich
HgeneRNF111chr15:59359282chr15:59193486ENST00000557998+614252_464562.0995.0Compositional biasNote=Ser-rich
HgeneRNF111chr15:59359282chr15:59193486ENST00000557998+614494_523562.0995.0Compositional biasNote=His-rich
HgeneRNF111chr15:59359282chr15:59193486ENST00000559209+614252_464562.0996.0Compositional biasNote=Ser-rich
HgeneRNF111chr15:59359282chr15:59193486ENST00000559209+614494_523562.0996.0Compositional biasNote=His-rich
HgeneRNF111chr15:59359282chr15:59193486ENST00000561186+513252_464562.01004.0Compositional biasNote=Ser-rich
HgeneRNF111chr15:59359282chr15:59193486ENST00000561186+513494_523562.01004.0Compositional biasNote=His-rich
TgeneSLTMchr15:59323901chr15:59209198ENST00000380516121609_72883.333333333333331035.0Coiled coilOntology_term=ECO:0000255
TgeneSLTMchr15:59359282chr15:59193486ENST00000380516421609_728187.01035.0Coiled coilOntology_term=ECO:0000255
TgeneSLTMchr15:59323901chr15:59209198ENST00000380516121108_23983.333333333333331035.0Compositional biasNote=Glu-rich
TgeneSLTMchr15:59323901chr15:59209198ENST00000380516121569_90683.333333333333331035.0Compositional biasNote=Arg/Glu-rich
TgeneSLTMchr15:59359282chr15:59193486ENST00000380516421569_906187.01035.0Compositional biasNote=Arg/Glu-rich
TgeneSLTMchr15:59323901chr15:59209198ENST00000380516121384_46283.333333333333331035.0DomainRRM
TgeneSLTMchr15:59359282chr15:59193486ENST00000380516421384_462187.01035.0DomainRRM

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF111chr15:59323901chr15:59209198ENST00000348370-214252_464293.3333333333333987.0Compositional biasNote=Ser-rich
HgeneRNF111chr15:59323901chr15:59209198ENST00000348370-214494_523293.3333333333333987.0Compositional biasNote=His-rich
HgeneRNF111chr15:59323901chr15:59209198ENST00000348370-214629_781293.3333333333333987.0Compositional biasNote=Pro-rich
HgeneRNF111chr15:59323901chr15:59209198ENST00000434298-214252_464293.33333333333331004.0Compositional biasNote=Ser-rich
HgeneRNF111chr15:59323901chr15:59209198ENST00000434298-214494_523293.33333333333331004.0Compositional biasNote=His-rich
HgeneRNF111chr15:59323901chr15:59209198ENST00000434298-214629_781293.33333333333331004.0Compositional biasNote=Pro-rich
HgeneRNF111chr15:59323901chr15:59209198ENST00000557998-214252_464293.3333333333333995.0Compositional biasNote=Ser-rich
HgeneRNF111chr15:59323901chr15:59209198ENST00000557998-214494_523293.3333333333333995.0Compositional biasNote=His-rich
HgeneRNF111chr15:59323901chr15:59209198ENST00000557998-214629_781293.3333333333333995.0Compositional biasNote=Pro-rich
HgeneRNF111chr15:59323901chr15:59209198ENST00000559209-214252_464293.3333333333333996.0Compositional biasNote=Ser-rich
HgeneRNF111chr15:59323901chr15:59209198ENST00000559209-214494_523293.3333333333333996.0Compositional biasNote=His-rich
HgeneRNF111chr15:59323901chr15:59209198ENST00000559209-214629_781293.3333333333333996.0Compositional biasNote=Pro-rich
HgeneRNF111chr15:59323901chr15:59209198ENST00000561186-113252_464293.33333333333331004.0Compositional biasNote=Ser-rich
HgeneRNF111chr15:59323901chr15:59209198ENST00000561186-113494_523293.33333333333331004.0Compositional biasNote=His-rich
HgeneRNF111chr15:59323901chr15:59209198ENST00000561186-113629_781293.33333333333331004.0Compositional biasNote=Pro-rich
HgeneRNF111chr15:59359282chr15:59193486ENST00000348370+614629_781562.0987.0Compositional biasNote=Pro-rich
HgeneRNF111chr15:59359282chr15:59193486ENST00000434298+614629_781562.01004.0Compositional biasNote=Pro-rich
HgeneRNF111chr15:59359282chr15:59193486ENST00000557998+614629_781562.0995.0Compositional biasNote=Pro-rich
HgeneRNF111chr15:59359282chr15:59193486ENST00000559209+614629_781562.0996.0Compositional biasNote=Pro-rich
HgeneRNF111chr15:59359282chr15:59193486ENST00000561186+513629_781562.01004.0Compositional biasNote=Pro-rich
HgeneRNF111chr15:59323901chr15:59209198ENST00000348370-214907_909293.3333333333333987.0RegionUbiquitin binding
HgeneRNF111chr15:59323901chr15:59209198ENST00000348370-214957_961293.3333333333333987.0RegionUbiquitin binding
HgeneRNF111chr15:59323901chr15:59209198ENST00000434298-214907_909293.33333333333331004.0RegionUbiquitin binding
HgeneRNF111chr15:59323901chr15:59209198ENST00000434298-214957_961293.33333333333331004.0RegionUbiquitin binding
HgeneRNF111chr15:59323901chr15:59209198ENST00000557998-214907_909293.3333333333333995.0RegionUbiquitin binding
HgeneRNF111chr15:59323901chr15:59209198ENST00000557998-214957_961293.3333333333333995.0RegionUbiquitin binding
HgeneRNF111chr15:59323901chr15:59209198ENST00000559209-214907_909293.3333333333333996.0RegionUbiquitin binding
HgeneRNF111chr15:59323901chr15:59209198ENST00000559209-214957_961293.3333333333333996.0RegionUbiquitin binding
HgeneRNF111chr15:59323901chr15:59209198ENST00000561186-113907_909293.33333333333331004.0RegionUbiquitin binding
HgeneRNF111chr15:59323901chr15:59209198ENST00000561186-113957_961293.33333333333331004.0RegionUbiquitin binding
HgeneRNF111chr15:59359282chr15:59193486ENST00000348370+614907_909562.0987.0RegionUbiquitin binding
HgeneRNF111chr15:59359282chr15:59193486ENST00000348370+614957_961562.0987.0RegionUbiquitin binding
HgeneRNF111chr15:59359282chr15:59193486ENST00000434298+614907_909562.01004.0RegionUbiquitin binding
HgeneRNF111chr15:59359282chr15:59193486ENST00000434298+614957_961562.01004.0RegionUbiquitin binding
HgeneRNF111chr15:59359282chr15:59193486ENST00000557998+614907_909562.0995.0RegionUbiquitin binding
HgeneRNF111chr15:59359282chr15:59193486ENST00000557998+614957_961562.0995.0RegionUbiquitin binding
HgeneRNF111chr15:59359282chr15:59193486ENST00000559209+614907_909562.0996.0RegionUbiquitin binding
HgeneRNF111chr15:59359282chr15:59193486ENST00000559209+614957_961562.0996.0RegionUbiquitin binding
HgeneRNF111chr15:59359282chr15:59193486ENST00000561186+513907_909562.01004.0RegionUbiquitin binding
HgeneRNF111chr15:59359282chr15:59193486ENST00000561186+513957_961562.01004.0RegionUbiquitin binding
HgeneRNF111chr15:59323901chr15:59209198ENST00000348370-214942_983293.3333333333333987.0Zinc fingerRING-type%3B atypical
HgeneRNF111chr15:59323901chr15:59209198ENST00000434298-214942_983293.33333333333331004.0Zinc fingerRING-type%3B atypical
HgeneRNF111chr15:59323901chr15:59209198ENST00000557998-214942_983293.3333333333333995.0Zinc fingerRING-type%3B atypical
HgeneRNF111chr15:59323901chr15:59209198ENST00000559209-214942_983293.3333333333333996.0Zinc fingerRING-type%3B atypical
HgeneRNF111chr15:59323901chr15:59209198ENST00000561186-113942_983293.33333333333331004.0Zinc fingerRING-type%3B atypical
HgeneRNF111chr15:59359282chr15:59193486ENST00000348370+614942_983562.0987.0Zinc fingerRING-type%3B atypical
HgeneRNF111chr15:59359282chr15:59193486ENST00000434298+614942_983562.01004.0Zinc fingerRING-type%3B atypical
HgeneRNF111chr15:59359282chr15:59193486ENST00000557998+614942_983562.0995.0Zinc fingerRING-type%3B atypical
HgeneRNF111chr15:59359282chr15:59193486ENST00000559209+614942_983562.0996.0Zinc fingerRING-type%3B atypical
HgeneRNF111chr15:59359282chr15:59193486ENST00000561186+513942_983562.01004.0Zinc fingerRING-type%3B atypical
TgeneSLTMchr15:59359282chr15:59193486ENST00000380516421108_239187.01035.0Compositional biasNote=Glu-rich
TgeneSLTMchr15:59323901chr15:59209198ENST0000038051612122_5683.333333333333331035.0DomainSAP
TgeneSLTMchr15:59359282chr15:59193486ENST0000038051642122_56187.01035.0DomainSAP


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>2044_RNF111_59359282_SLTM_59193486_ranked_0.pdbRNF1115932390159359282ENST00000380516SLTMchr1559193486-
MSQWTPEYNELYTLKVDMKSEIPSDAPKTQESLKGILLHPEPIGAAKSFPAGVEMINSKVGNEFSHLCDDSQKQEKEMNGNQQEQEKSLV
VRKKRKSQQAGPSYVQNCVKENQGILGLRQHLGTPSDEDNDSSFSDCLSSPSSSLHFGDSDTVTSDEDKEVSVRHSQTILNAKSRSHSAR
SHKWPRTETESVSGLLMKRPCLHGSSLRRLPCRKRFVKNNSSQRTQKQKERILMQRKKREVLARRKYALLPSSSSSSENDLSSESSSSSS
TEGEEDLFVSASENHQNNPAVPSGSIDEDVVVIEASSTPQVTANEEINVTSTDSEVEIVTVGESYRSRSTLGHSRSHWSQGSSSHASRPQ
EPRNRSRISTVIQPLRQNAAEVVDLTVDEDEPTVVPTTSARMESQATSASINNSNPSTSEQASDTASAVTSSQPSTVSETSATLTSNSTT
GTSIGDDSRRTTSSAVTETGPPAMPRLPSCCPQHSPCGGSSQNHHALGHPHTSCFQQHGHHFQHHHHHHHTPHPAVPVSPSFSDPACPVE
RPPQVQAPCGANSSSGTSYHEQDGEEEENEKDIAGSGDGTQEVSKPLPSEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITL
DFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSST
GASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSS
TEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKD
EKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRL
REHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIARE
REELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDR
FVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKS
EGSMSTDKRETRVERPERSGREVSGHSVRGAPPGNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRDTSGPRKEWHGPPSQG
1409


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
RNF111_pLDDT.png
all structure
all structure
SLTM_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RNF111
SLTM


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRNF111chr15:59323901chr15:59209198ENST00000348370-214241_404293.3333333333333987.0AXIN1
HgeneRNF111chr15:59323901chr15:59209198ENST00000434298-214241_404293.33333333333331004.0AXIN1
HgeneRNF111chr15:59323901chr15:59209198ENST00000557998-214241_404293.3333333333333995.0AXIN1
HgeneRNF111chr15:59323901chr15:59209198ENST00000559209-214241_404293.3333333333333996.0AXIN1
HgeneRNF111chr15:59323901chr15:59209198ENST00000561186-113241_404293.33333333333331004.0AXIN1


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Related Drugs to RNF111-SLTM


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RNF111-SLTM


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource