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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:RNF43-AKAP9

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RNF43-AKAP9
FusionPDB ID: 75098
FusionGDB2.0 ID: 75098
HgeneTgene
Gene symbol

RNF43

AKAP9

Gene ID

54894

10142

Gene namering finger protein 43A-kinase anchoring protein 9
SynonymsRNF124|SSPCS|URCCAKAP-9|AKAP350|AKAP450|CG-NAP|HYPERION|LQT11|MU-RMS-40.16A|PPP1R45|PRKA9|YOTIAO
Cytomap

17q22

7q21.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF43RING-type E3 ubiquitin transferase RNF43A-kinase anchor protein 9A kinase (PRKA) anchor protein (yotiao) 9A kinase (PRKA) anchor protein 9A-kinase anchor protein 350 kDaA-kinase anchor protein 450 kDaAKAP 120-like proteinAKAP9-BRAF fusion proteincentrosome- and Golgi-localized PKN-associ
Modification date2020031320200328
UniProtAcc.

Q99996

Ensembl transtripts involved in fusion geneENST idsENST00000407977, ENST00000500597, 
ENST00000577716, ENST00000583753, 
ENST00000584437, ENST00000577625, 
ENST00000580014, ENST00000581868, 
ENST00000394564, ENST00000491695, 
ENST00000356239, ENST00000358100, 
ENST00000359028, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 10 X 7=84011 X 17 X 7=1309
# samples 1315
** MAII scorelog2(13/840*10)=-2.69187770463767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1309*10)=-3.12543069144936
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RNF43 [Title/Abstract] AND AKAP9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RNF43(56492686)-AKAP9(91674321), # samples:1
Anticipated loss of major functional domain due to fusion event.RNF43-AKAP9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RNF43-AKAP9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RNF43-AKAP9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RNF43-AKAP9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RNF43-AKAP9 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
RNF43-AKAP9 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRNF43

GO:0006511

ubiquitin-dependent protein catabolic process

22895187

HgeneRNF43

GO:0016567

protein ubiquitination

22575959

HgeneRNF43

GO:0038018

Wnt receptor catabolic process

22895187

TgeneAKAP9

GO:0098962

regulation of postsynaptic neurotransmitter receptor activity

10390370

TgeneAKAP9

GO:1903358

regulation of Golgi organization

27666745


check buttonFusion gene breakpoints across RNF43 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AKAP9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4H5RNF43chr17

56492686

-AKAP9chr7

91674321

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000500597RNF43chr1756492686-ENST00000356239AKAP9chr791674321+781674077173012176
ENST00000500597RNF43chr1756492686-ENST00000358100AKAP9chr791674321+763074077171152114
ENST00000500597RNF43chr1756492686-ENST00000359028AKAP9chr791674321+779274077172772168
ENST00000407977RNF43chr1756492686-ENST00000356239AKAP9chr791674321+8049973100475342176
ENST00000407977RNF43chr1756492686-ENST00000358100AKAP9chr791674321+7863973100473482114
ENST00000407977RNF43chr1756492686-ENST00000359028AKAP9chr791674321+8025973100475102168

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000500597ENST00000356239RNF43chr1756492686-AKAP9chr791674321+0.0052578930.99474204
ENST00000500597ENST00000358100RNF43chr1756492686-AKAP9chr791674321+0.0052513790.99474865
ENST00000500597ENST00000359028RNF43chr1756492686-AKAP9chr791674321+0.004723870.9952761
ENST00000407977ENST00000356239RNF43chr1756492686-AKAP9chr791674321+0.0059496760.9940503
ENST00000407977ENST00000358100RNF43chr1756492686-AKAP9chr791674321+0.0059369510.9940631
ENST00000407977ENST00000359028RNF43chr1756492686-AKAP9chr791674321+0.0053606490.99463934

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>75098_75098_1_RNF43-AKAP9_RNF43_chr17_56492686_ENST00000407977_AKAP9_chr7_91674321_ENST00000356239_length(amino acids)=2176AA_BP=
MKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTEL
SQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRARE
QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKL
MKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE
QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA
KPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAM
STQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQ
ELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSV
NVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIV
NLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEI
AEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLV
KETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSE
CSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREIC
SSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTI
SSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMEC
LQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT
KLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNL
LLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQ
LEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQ
EFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQ
KASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIR
WYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESF
RKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININRDGF
GLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLG

--------------------------------------------------------------

>75098_75098_2_RNF43-AKAP9_RNF43_chr17_56492686_ENST00000407977_AKAP9_chr7_91674321_ENST00000358100_length(amino acids)=2114AA_BP=
MKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTEL
SQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRARE
QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKL
MKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE
QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA
KPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAM
STQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQ
ELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSV
NVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIV
NLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEI
AEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLV
KETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSE
CSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGLLRAVHNEGMQVLSLTES
PYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALG
TTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSM
KDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGR
SEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELH
AQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVE
DLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNG
GGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNA
ELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRND
SLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSI
AISRMKFLVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNPGSLA

--------------------------------------------------------------

>75098_75098_3_RNF43-AKAP9_RNF43_chr17_56492686_ENST00000407977_AKAP9_chr7_91674321_ENST00000359028_length(amino acids)=2168AA_BP=
MKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTEL
SQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRARE
QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKL
MKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE
QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA
KPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAM
STQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQ
ELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSV
NVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIV
NLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEI
AEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLV
KETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSE
CSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEVFGFYNMCFSTLCDSGSDW
GQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLIT
KMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRS
LLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTL
KAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQL
LNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRI
VELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELE
REEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQF
ETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAG
RDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQK
KYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININRDGFGLNQGAEK
TDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTT

--------------------------------------------------------------

>75098_75098_4_RNF43-AKAP9_RNF43_chr17_56492686_ENST00000500597_AKAP9_chr7_91674321_ENST00000356239_length(amino acids)=2176AA_BP=
MKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTEL
SQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRARE
QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKL
MKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE
QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA
KPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAM
STQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQ
ELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSV
NVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIV
NLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEI
AEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLV
KETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSE
CSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREIC
SSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTI
SSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMEC
LQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT
KLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNL
LLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQ
LEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQ
EFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQ
KASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIR
WYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESF
RKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININRDGF
GLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLG

--------------------------------------------------------------

>75098_75098_5_RNF43-AKAP9_RNF43_chr17_56492686_ENST00000500597_AKAP9_chr7_91674321_ENST00000358100_length(amino acids)=2114AA_BP=
MKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTEL
SQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRARE
QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKL
MKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE
QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA
KPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAM
STQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQ
ELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSV
NVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIV
NLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEI
AEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLV
KETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSE
CSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGLLRAVHNEGMQVLSLTES
PYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALG
TTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSM
KDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGR
SEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELH
AQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVE
DLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNG
GGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNA
ELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRND
SLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSI
AISRMKFLVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNPGSLA

--------------------------------------------------------------

>75098_75098_6_RNF43-AKAP9_RNF43_chr17_56492686_ENST00000500597_AKAP9_chr7_91674321_ENST00000359028_length(amino acids)=2168AA_BP=
MKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTEL
SQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRARE
QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKL
MKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE
QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA
KPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAM
STQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQ
ELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSV
NVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIV
NLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEI
AEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLV
KETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSE
CSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEVFGFYNMCFSTLCDSGSDW
GQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLIT
KMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRS
LLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTL
KAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQL
LNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRI
VELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELE
REEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQF
ETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAG
RDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQK
KYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININRDGFGLNQGAEK
TDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTT

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:56492686/chr7:91674321)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AKAP9

Q99996

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus (PubMed:10202149, PubMed:15047863). Required for microtubule nucleation at the cis-side of the Golgi apparatus (PubMed:15047863, PubMed:19242490). Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:25657325). In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery (PubMed:29162697). {ECO:0000269|PubMed:10202149, ECO:0000269|PubMed:15047863, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}.; FUNCTION: [Isoform 4]: Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. {ECO:0000269|PubMed:9482789}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035623919501845_24431720.66666666666673908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035623919502532_25491720.66666666666673908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035623919502591_27641720.66666666666673908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035623919503061_30881720.66666666666673908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035623919503120_34661720.66666666666673908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035623919503583_36851720.66666666666673908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035810020491845_24431732.66666666666673858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035810020492532_25491732.66666666666673858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035810020492591_27641732.66666666666673858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035810020493061_30881732.66666666666673858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035810020493120_34661732.66666666666673858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035810020493583_36851732.66666666666673858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035902820501845_24431732.66666666666673912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035902820502532_25491732.66666666666673912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035902820502591_27641732.66666666666673912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035902820503061_30881732.66666666666673912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035902820503120_34661732.66666666666673912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035902820503583_36851732.66666666666673912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035623919501834_27601720.66666666666673908.0Compositional biasNote=Glu-rich
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035623919503722_37261720.66666666666673908.0Compositional biasNote=Poly-Leu
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035810020491834_27601732.66666666666673858.0Compositional biasNote=Glu-rich
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035810020493722_37261732.66666666666673858.0Compositional biasNote=Poly-Leu
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035902820501834_27601732.66666666666673912.0Compositional biasNote=Glu-rich
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035902820503722_37261732.66666666666673912.0Compositional biasNote=Poly-Leu
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035623919502542_25551720.66666666666673908.0RegionNote=PKA-RII subunit binding domain
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035810020492542_25551732.66666666666673858.0RegionNote=PKA-RII subunit binding domain
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035902820502542_25551732.66666666666673912.0RegionNote=PKA-RII subunit binding domain

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF43chr17:56492686chr7:91674321ENST00000407977-210443_50384.0784.0Compositional biasNote=Ser-rich
HgeneRNF43chr17:56492686chr7:91674321ENST00000407977-210547_55784.0784.0Compositional biasNote=His-rich
HgeneRNF43chr17:56492686chr7:91674321ENST00000407977-210569_76084.0784.0Compositional biasNote=Pro-rich
HgeneRNF43chr17:56492686chr7:91674321ENST00000500597-29443_50384.0743.0Compositional biasNote=Ser-rich
HgeneRNF43chr17:56492686chr7:91674321ENST00000500597-29547_55784.0743.0Compositional biasNote=His-rich
HgeneRNF43chr17:56492686chr7:91674321ENST00000500597-29569_76084.0743.0Compositional biasNote=Pro-rich
HgeneRNF43chr17:56492686chr7:91674321ENST00000577625-19443_5030657.0Compositional biasNote=Ser-rich
HgeneRNF43chr17:56492686chr7:91674321ENST00000577625-19547_5570657.0Compositional biasNote=His-rich
HgeneRNF43chr17:56492686chr7:91674321ENST00000577625-19569_7600657.0Compositional biasNote=Pro-rich
HgeneRNF43chr17:56492686chr7:91674321ENST00000577716-210443_50384.0784.0Compositional biasNote=Ser-rich
HgeneRNF43chr17:56492686chr7:91674321ENST00000577716-210547_55784.0784.0Compositional biasNote=His-rich
HgeneRNF43chr17:56492686chr7:91674321ENST00000577716-210569_76084.0784.0Compositional biasNote=Pro-rich
HgeneRNF43chr17:56492686chr7:91674321ENST00000583753-18443_50384.0743.0Compositional biasNote=Ser-rich
HgeneRNF43chr17:56492686chr7:91674321ENST00000583753-18547_55784.0743.0Compositional biasNote=His-rich
HgeneRNF43chr17:56492686chr7:91674321ENST00000583753-18569_76084.0743.0Compositional biasNote=Pro-rich
HgeneRNF43chr17:56492686chr7:91674321ENST00000584437-19443_50384.0784.0Compositional biasNote=Ser-rich
HgeneRNF43chr17:56492686chr7:91674321ENST00000584437-19547_55784.0784.0Compositional biasNote=His-rich
HgeneRNF43chr17:56492686chr7:91674321ENST00000584437-19569_76084.0784.0Compositional biasNote=Pro-rich
HgeneRNF43chr17:56492686chr7:91674321ENST00000407977-210219_78384.0784.0Topological domainCytoplasmic
HgeneRNF43chr17:56492686chr7:91674321ENST00000407977-21024_19784.0784.0Topological domainExtracellular
HgeneRNF43chr17:56492686chr7:91674321ENST00000500597-29219_78384.0743.0Topological domainCytoplasmic
HgeneRNF43chr17:56492686chr7:91674321ENST00000500597-2924_19784.0743.0Topological domainExtracellular
HgeneRNF43chr17:56492686chr7:91674321ENST00000577625-19219_7830657.0Topological domainCytoplasmic
HgeneRNF43chr17:56492686chr7:91674321ENST00000577625-1924_1970657.0Topological domainExtracellular
HgeneRNF43chr17:56492686chr7:91674321ENST00000577716-210219_78384.0784.0Topological domainCytoplasmic
HgeneRNF43chr17:56492686chr7:91674321ENST00000577716-21024_19784.0784.0Topological domainExtracellular
HgeneRNF43chr17:56492686chr7:91674321ENST00000583753-18219_78384.0743.0Topological domainCytoplasmic
HgeneRNF43chr17:56492686chr7:91674321ENST00000583753-1824_19784.0743.0Topological domainExtracellular
HgeneRNF43chr17:56492686chr7:91674321ENST00000584437-19219_78384.0784.0Topological domainCytoplasmic
HgeneRNF43chr17:56492686chr7:91674321ENST00000584437-1924_19784.0784.0Topological domainExtracellular
HgeneRNF43chr17:56492686chr7:91674321ENST00000407977-210198_21884.0784.0TransmembraneHelical
HgeneRNF43chr17:56492686chr7:91674321ENST00000500597-29198_21884.0743.0TransmembraneHelical
HgeneRNF43chr17:56492686chr7:91674321ENST00000577625-19198_2180657.0TransmembraneHelical
HgeneRNF43chr17:56492686chr7:91674321ENST00000577716-210198_21884.0784.0TransmembraneHelical
HgeneRNF43chr17:56492686chr7:91674321ENST00000583753-18198_21884.0743.0TransmembraneHelical
HgeneRNF43chr17:56492686chr7:91674321ENST00000584437-19198_21884.0784.0TransmembraneHelical
HgeneRNF43chr17:56492686chr7:91674321ENST00000407977-210272_31384.0784.0Zinc fingerRING-type%3B atypical
HgeneRNF43chr17:56492686chr7:91674321ENST00000500597-29272_31384.0743.0Zinc fingerRING-type%3B atypical
HgeneRNF43chr17:56492686chr7:91674321ENST00000577625-19272_3130657.0Zinc fingerRING-type%3B atypical
HgeneRNF43chr17:56492686chr7:91674321ENST00000577716-210272_31384.0784.0Zinc fingerRING-type%3B atypical
HgeneRNF43chr17:56492686chr7:91674321ENST00000583753-18272_31384.0743.0Zinc fingerRING-type%3B atypical
HgeneRNF43chr17:56492686chr7:91674321ENST00000584437-19272_31384.0784.0Zinc fingerRING-type%3B atypical
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035623919501088_11731720.66666666666673908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035623919501241_12681720.66666666666673908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035623919501324_13801720.66666666666673908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035623919501422_14471720.66666666666673908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST000003562391950152_9021720.66666666666673908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035623919501573_16471720.66666666666673908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST000003562391950932_10101720.66666666666673908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035810020491088_11731732.66666666666673858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035810020491241_12681732.66666666666673858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035810020491324_13801732.66666666666673858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035810020491422_14471732.66666666666673858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST000003581002049152_9021732.66666666666673858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035810020491573_16471732.66666666666673858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST000003581002049932_10101732.66666666666673858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035902820501088_11731732.66666666666673912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035902820501241_12681732.66666666666673912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035902820501324_13801732.66666666666673912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035902820501422_14471732.66666666666673912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST000003590282050152_9021732.66666666666673912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST0000035902820501573_16471732.66666666666673912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST000003590282050932_10101732.66666666666673912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr17:56492686chr7:91674321ENST000003562391950191_2801720.66666666666673908.0Compositional biasNote=Gln-rich
TgeneAKAP9chr17:56492686chr7:91674321ENST000003562391950309_9981720.66666666666673908.0Compositional biasNote=Glu-rich
TgeneAKAP9chr17:56492686chr7:91674321ENST000003581002049191_2801732.66666666666673858.0Compositional biasNote=Gln-rich
TgeneAKAP9chr17:56492686chr7:91674321ENST000003581002049309_9981732.66666666666673858.0Compositional biasNote=Glu-rich
TgeneAKAP9chr17:56492686chr7:91674321ENST000003590282050191_2801732.66666666666673912.0Compositional biasNote=Gln-rich
TgeneAKAP9chr17:56492686chr7:91674321ENST000003590282050309_9981732.66666666666673912.0Compositional biasNote=Glu-rich


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
AKAP9TACC3, FNBP1, TRIP10, PRKAR2A, KCNQ1, CLIC1, CALM2, CALM1, TUBGCP3, PKN1, Csnk1d, Csnk1e, CSNK1E, CSNK1D, PMS1, CDC5L, DISC1, TNIK, CEBPA, CCNE1, TSG101, gag-pol, CDK5RAP2, KDM1A, TDP2, PCNT, GSK3A, RASSF2, SUV39H2, PRKACA, PRKACB, MAGEA6, HNRNPM, SSX2, BLZF1, USO1, MAGED1, IKZF3, WAC, THAP1, PRDM14, USHBP1, C1orf94, SAMD3, SUZ12, RNF2, BMI1, ROPN1L, MAPRE1, CEP170, CCDC68, PRKAR2B, HERC2, GPC4, DYNLL1, HUWE1, FGFR1OP, THOC2, CEP170P1, Mapre1, Prkacb, Prkar2a, Prkar2b, Uso1, Fgfr1op, Cdk5rap2, PCGF1, NANOG, ATOH1, TPTE2, PDE4DIP, PRKACG, C1orf87, DNAJC10, BIRC6, TPM2, HEY1, PPIE, RBM14, PCM1, RPA2, KIF19, GTSE1, PARD6G, KLC4, CASK, PRC1, FMR1, CTBP1, RBM10, NDEL1, SF3B2, MED1, SLAIN1, FXR2, YWHAE, AKAP9, PKP2, MYO5A, DVL2, AGR2, KIAA1429, nsp13, VPS9D1, THOC1, RSRC2, SNRPB, GLIS2, BEX2, CCDC146, ABI2, FAM46B, SNF8, CCDC116, SCNM1, TLX3, SSX5, SSX3, LMO1, FAM90A1, TCEANC, CTNNA3, HDDC3, PTPN6, HNRNPC, HMGA1, RFC5, HSPD1, DHX9, HNRNPCL2, VDAC2, NONO, SMC3, nsp16, ORF6, TULP3, CIT, KIF14, MTX2, nsp13ab, HDAC1, ACBD5, AP2B1, CAMSAP2, CEP135, DCTN2, GOLGA2, IMPDH2, KRT19, KRT8, LATS1, MAPRE3, NDC80, PFN1, PXN, SEPT10, STIL, LOC338797, CTCFL, EFCAB1, SOGA1, OR10H1, STK11, PIGF, SYCE1, WHAMMP3, COQ3, RAMP1, ABCF3, RNF145, DDX55, DYNLL2, SLU7, BRK1, ZBTB44, FTSJ3, CCDC71, VDR, BNIP1, LINC00346, CEP57, ZNF252P-AS1, CARD9, NDUFAF1, ROPN1, NOLC1,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RNF43
AKAP9all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to RNF43-AKAP9


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RNF43-AKAP9


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneAKAP9C2678483Long Qt Syndrome 114CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneAKAP9C0035828Romano-Ward Syndrome1ORPHANET
TgeneAKAP9C0037274Dermatologic disorders1CTD_human
TgeneAKAP9C0274861Arsenic Poisoning, Inorganic1CTD_human
TgeneAKAP9C0274862Nervous System, Organic Arsenic Poisoning1CTD_human
TgeneAKAP9C0311375Arsenic Poisoning1CTD_human
TgeneAKAP9C0751851Arsenic Encephalopathy1CTD_human
TgeneAKAP9C0751852Arsenic Induced Polyneuropathy1CTD_human
TgeneAKAP9C1142166Brugada Syndrome (disorder)1ORPHANET