UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use

Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:ROBO1-PSMD6

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ROBO1-PSMD6
FusionPDB ID: 75261
FusionGDB2.0 ID: 75261
HgeneTgene
Gene symbol

ROBO1

PSMD6

Gene ID

6091

9861

Gene nameroundabout guidance receptor 1proteasome 26S subunit, non-ATPase 6
SynonymsDUTT1|SAX3Rpn7|S10|SGA-113M|p42A|p44S10
Cytomap

3p12.3

3p14.1

Type of geneprotein-codingprotein-coding
Descriptionroundabout homolog 1deleted in U twenty twentyroundabout, axon guidance receptor, homolog 126S proteasome non-ATPase regulatory subunit 6breast cancer-associated protein SGA-113Mphosphonoformate immuno-associated protein 4proteasome (prosome, macropain) 26S subunit, non-ATPase, 6proteasome regulatory particle subunit p44S10
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000464233, ENST00000436010, 
ENST00000467549, ENST00000495273, 
ENST00000466906, 
ENST00000295901, 
ENST00000394431, ENST00000482510, 
ENST00000492933, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 16 X 7=20165 X 4 X 4=80
# samples 185
** MAII scorelog2(18/2016*10)=-3.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ROBO1 [Title/Abstract] AND PSMD6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ROBO1(78987751)-PSMD6(64008199), # samples:1
Anticipated loss of major functional domain due to fusion event.ROBO1-PSMD6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ROBO1-PSMD6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ROBO1-PSMD6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ROBO1-PSMD6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ROBO1-PSMD6 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
ROBO1-PSMD6 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ROBO1-PSMD6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneROBO1

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

12504588

HgeneROBO1

GO:0021836

chemorepulsion involved in postnatal olfactory bulb interneuron migration

15207848

HgeneROBO1

GO:0050772

positive regulation of axonogenesis

12504588

HgeneROBO1

GO:0050925

negative regulation of negative chemotaxis

11748139


check buttonFusion gene breakpoints across ROBO1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PSMD6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-B0-5703-11AROBO1chr3

78987751

-PSMD6chr3

64008199

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000436010ROBO1chr378987751-ENST00000295901PSMD6chr364008199-252413809982404468
ENST00000436010ROBO1chr378987751-ENST00000492933PSMD6chr364008199-251813809982404468
ENST00000436010ROBO1chr378987751-ENST00000394431PSMD6chr364008199-251813809982404468
ENST00000436010ROBO1chr378987751-ENST00000482510PSMD6chr364008199-248913809982404468
ENST00000495273ROBO1chr378987751-ENST00000295901PSMD6chr364008199-20809365541960468
ENST00000495273ROBO1chr378987751-ENST00000492933PSMD6chr364008199-20749365541960468
ENST00000495273ROBO1chr378987751-ENST00000394431PSMD6chr364008199-20749365541960468
ENST00000495273ROBO1chr378987751-ENST00000482510PSMD6chr364008199-20459365541960468
ENST00000467549ROBO1chr378987751-ENST00000295901PSMD6chr364008199-1609465831489468
ENST00000467549ROBO1chr378987751-ENST00000492933PSMD6chr364008199-1603465831489468
ENST00000467549ROBO1chr378987751-ENST00000394431PSMD6chr364008199-1603465831489468
ENST00000467549ROBO1chr378987751-ENST00000482510PSMD6chr364008199-1574465831489468

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000436010ENST00000295901ROBO1chr378987751-PSMD6chr364008199-0.0017259010.9982741
ENST00000436010ENST00000492933ROBO1chr378987751-PSMD6chr364008199-0.0017576190.9982424
ENST00000436010ENST00000394431ROBO1chr378987751-PSMD6chr364008199-0.0017576190.9982424
ENST00000436010ENST00000482510ROBO1chr378987751-PSMD6chr364008199-0.0019709170.99802905
ENST00000495273ENST00000295901ROBO1chr378987751-PSMD6chr364008199-0.0010854570.9989146
ENST00000495273ENST00000492933ROBO1chr378987751-PSMD6chr364008199-0.0011083840.99889165
ENST00000495273ENST00000394431ROBO1chr378987751-PSMD6chr364008199-0.0011083840.99889165
ENST00000495273ENST00000482510ROBO1chr378987751-PSMD6chr364008199-0.001263070.9987369
ENST00000467549ENST00000295901ROBO1chr378987751-PSMD6chr364008199-0.0007213720.9992786
ENST00000467549ENST00000492933ROBO1chr378987751-PSMD6chr364008199-0.0007335660.99926645
ENST00000467549ENST00000394431ROBO1chr378987751-PSMD6chr364008199-0.0007335660.99926645
ENST00000467549ENST00000482510ROBO1chr378987751-PSMD6chr364008199-0.0008378350.9991622

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>75261_75261_1_ROBO1-PSMD6_ROBO1_chr3_78987751_ENST00000436010_PSMD6_chr3_64008199_ENST00000295901_length(amino acids)=468AA_BP=128
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF
LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVANMAPYYEALCKSLDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIR
DAMMAKAEYLCRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAI
RDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAVVEQE
MKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQETIK

--------------------------------------------------------------

>75261_75261_2_ROBO1-PSMD6_ROBO1_chr3_78987751_ENST00000436010_PSMD6_chr3_64008199_ENST00000394431_length(amino acids)=468AA_BP=128
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF
LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVANMAPYYEALCKSLDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIR
DAMMAKAEYLCRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAI
RDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAVVEQE
MKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQETIK

--------------------------------------------------------------

>75261_75261_3_ROBO1-PSMD6_ROBO1_chr3_78987751_ENST00000436010_PSMD6_chr3_64008199_ENST00000482510_length(amino acids)=468AA_BP=128
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF
LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVANMAPYYEALCKSLDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIR
DAMMAKAEYLCRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAI
RDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAVVEQE
MKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQETIK

--------------------------------------------------------------

>75261_75261_4_ROBO1-PSMD6_ROBO1_chr3_78987751_ENST00000436010_PSMD6_chr3_64008199_ENST00000492933_length(amino acids)=468AA_BP=128
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF
LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVANMAPYYEALCKSLDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIR
DAMMAKAEYLCRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAI
RDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAVVEQE
MKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQETIK

--------------------------------------------------------------

>75261_75261_5_ROBO1-PSMD6_ROBO1_chr3_78987751_ENST00000467549_PSMD6_chr3_64008199_ENST00000295901_length(amino acids)=468AA_BP=128
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF
LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVANMAPYYEALCKSLDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIR
DAMMAKAEYLCRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAI
RDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAVVEQE
MKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQETIK

--------------------------------------------------------------

>75261_75261_6_ROBO1-PSMD6_ROBO1_chr3_78987751_ENST00000467549_PSMD6_chr3_64008199_ENST00000394431_length(amino acids)=468AA_BP=128
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF
LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVANMAPYYEALCKSLDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIR
DAMMAKAEYLCRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAI
RDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAVVEQE
MKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQETIK

--------------------------------------------------------------

>75261_75261_7_ROBO1-PSMD6_ROBO1_chr3_78987751_ENST00000467549_PSMD6_chr3_64008199_ENST00000482510_length(amino acids)=468AA_BP=128
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF
LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVANMAPYYEALCKSLDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIR
DAMMAKAEYLCRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAI
RDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAVVEQE
MKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQETIK

--------------------------------------------------------------

>75261_75261_8_ROBO1-PSMD6_ROBO1_chr3_78987751_ENST00000467549_PSMD6_chr3_64008199_ENST00000492933_length(amino acids)=468AA_BP=128
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF
LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVANMAPYYEALCKSLDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIR
DAMMAKAEYLCRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAI
RDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAVVEQE
MKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQETIK

--------------------------------------------------------------

>75261_75261_9_ROBO1-PSMD6_ROBO1_chr3_78987751_ENST00000495273_PSMD6_chr3_64008199_ENST00000295901_length(amino acids)=468AA_BP=128
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF
LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVANMAPYYEALCKSLDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIR
DAMMAKAEYLCRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAI
RDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAVVEQE
MKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQETIK

--------------------------------------------------------------

>75261_75261_10_ROBO1-PSMD6_ROBO1_chr3_78987751_ENST00000495273_PSMD6_chr3_64008199_ENST00000394431_length(amino acids)=468AA_BP=128
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF
LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVANMAPYYEALCKSLDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIR
DAMMAKAEYLCRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAI
RDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAVVEQE
MKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQETIK

--------------------------------------------------------------

>75261_75261_11_ROBO1-PSMD6_ROBO1_chr3_78987751_ENST00000495273_PSMD6_chr3_64008199_ENST00000482510_length(amino acids)=468AA_BP=128
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF
LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVANMAPYYEALCKSLDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIR
DAMMAKAEYLCRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAI
RDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAVVEQE
MKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQETIK

--------------------------------------------------------------

>75261_75261_12_ROBO1-PSMD6_ROBO1_chr3_78987751_ENST00000495273_PSMD6_chr3_64008199_ENST00000492933_length(amino acids)=468AA_BP=128
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF
LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVANMAPYYEALCKSLDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIR
DAMMAKAEYLCRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAI
RDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAVVEQE
MKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQETIK

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:78987751/chr3:64008199)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneROBO1chr3:78987751chr3:64008199ENST00000464233-43168_164166.333333333333341652.0DomainNote=Ig-like C2-type 1
TgenePSMD6chr3:78987751chr3:64008199ENST0000029590108193_36148.333333333333336390.0DomainPCI
TgenePSMD6chr3:78987751chr3:64008199ENST0000039443108193_36110.333333333333334352.0DomainPCI

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneROBO1chr3:78987751chr3:64008199ENST00000436010-229170_257127.333333333333331613.0DomainNote=Ig-like C2-type 2
HgeneROBO1chr3:78987751chr3:64008199ENST00000436010-229262_346127.333333333333331613.0DomainNote=Ig-like C2-type 3
HgeneROBO1chr3:78987751chr3:64008199ENST00000436010-229351_446127.333333333333331613.0DomainNote=Ig-like C2-type 4
HgeneROBO1chr3:78987751chr3:64008199ENST00000436010-229455_541127.333333333333331613.0DomainNote=Ig-like C2-type 5
HgeneROBO1chr3:78987751chr3:64008199ENST00000436010-229563_657127.333333333333331613.0DomainFibronectin type-III 1
HgeneROBO1chr3:78987751chr3:64008199ENST00000436010-229676_773127.333333333333331613.0DomainFibronectin type-III 2
HgeneROBO1chr3:78987751chr3:64008199ENST00000436010-22968_164127.333333333333331613.0DomainNote=Ig-like C2-type 1
HgeneROBO1chr3:78987751chr3:64008199ENST00000436010-229778_874127.333333333333331613.0DomainFibronectin type-III 3
HgeneROBO1chr3:78987751chr3:64008199ENST00000464233-431170_257166.333333333333341652.0DomainNote=Ig-like C2-type 2
HgeneROBO1chr3:78987751chr3:64008199ENST00000464233-431262_346166.333333333333341652.0DomainNote=Ig-like C2-type 3
HgeneROBO1chr3:78987751chr3:64008199ENST00000464233-431351_446166.333333333333341652.0DomainNote=Ig-like C2-type 4
HgeneROBO1chr3:78987751chr3:64008199ENST00000464233-431455_541166.333333333333341652.0DomainNote=Ig-like C2-type 5
HgeneROBO1chr3:78987751chr3:64008199ENST00000464233-431563_657166.333333333333341652.0DomainFibronectin type-III 1
HgeneROBO1chr3:78987751chr3:64008199ENST00000464233-431676_773166.333333333333341652.0DomainFibronectin type-III 2
HgeneROBO1chr3:78987751chr3:64008199ENST00000464233-431778_874166.333333333333341652.0DomainFibronectin type-III 3
HgeneROBO1chr3:78987751chr3:64008199ENST00000467549-229170_257127.333333333333331552.0DomainNote=Ig-like C2-type 2
HgeneROBO1chr3:78987751chr3:64008199ENST00000467549-229262_346127.333333333333331552.0DomainNote=Ig-like C2-type 3
HgeneROBO1chr3:78987751chr3:64008199ENST00000467549-229351_446127.333333333333331552.0DomainNote=Ig-like C2-type 4
HgeneROBO1chr3:78987751chr3:64008199ENST00000467549-229455_541127.333333333333331552.0DomainNote=Ig-like C2-type 5
HgeneROBO1chr3:78987751chr3:64008199ENST00000467549-229563_657127.333333333333331552.0DomainFibronectin type-III 1
HgeneROBO1chr3:78987751chr3:64008199ENST00000467549-229676_773127.333333333333331552.0DomainFibronectin type-III 2
HgeneROBO1chr3:78987751chr3:64008199ENST00000467549-22968_164127.333333333333331552.0DomainNote=Ig-like C2-type 1
HgeneROBO1chr3:78987751chr3:64008199ENST00000467549-229778_874127.333333333333331552.0DomainFibronectin type-III 3
HgeneROBO1chr3:78987751chr3:64008199ENST00000495273-229170_257127.333333333333331607.0DomainNote=Ig-like C2-type 2
HgeneROBO1chr3:78987751chr3:64008199ENST00000495273-229262_346127.333333333333331607.0DomainNote=Ig-like C2-type 3
HgeneROBO1chr3:78987751chr3:64008199ENST00000495273-229351_446127.333333333333331607.0DomainNote=Ig-like C2-type 4
HgeneROBO1chr3:78987751chr3:64008199ENST00000495273-229455_541127.333333333333331607.0DomainNote=Ig-like C2-type 5
HgeneROBO1chr3:78987751chr3:64008199ENST00000495273-229563_657127.333333333333331607.0DomainFibronectin type-III 1
HgeneROBO1chr3:78987751chr3:64008199ENST00000495273-229676_773127.333333333333331607.0DomainFibronectin type-III 2
HgeneROBO1chr3:78987751chr3:64008199ENST00000495273-22968_164127.333333333333331607.0DomainNote=Ig-like C2-type 1
HgeneROBO1chr3:78987751chr3:64008199ENST00000495273-229778_874127.333333333333331607.0DomainFibronectin type-III 3
HgeneROBO1chr3:78987751chr3:64008199ENST00000436010-22926_897127.333333333333331613.0Topological domainExtracellular
HgeneROBO1chr3:78987751chr3:64008199ENST00000436010-229919_1651127.333333333333331613.0Topological domainCytoplasmic
HgeneROBO1chr3:78987751chr3:64008199ENST00000464233-43126_897166.333333333333341652.0Topological domainExtracellular
HgeneROBO1chr3:78987751chr3:64008199ENST00000464233-431919_1651166.333333333333341652.0Topological domainCytoplasmic
HgeneROBO1chr3:78987751chr3:64008199ENST00000467549-22926_897127.333333333333331552.0Topological domainExtracellular
HgeneROBO1chr3:78987751chr3:64008199ENST00000467549-229919_1651127.333333333333331552.0Topological domainCytoplasmic
HgeneROBO1chr3:78987751chr3:64008199ENST00000495273-22926_897127.333333333333331607.0Topological domainExtracellular
HgeneROBO1chr3:78987751chr3:64008199ENST00000495273-229919_1651127.333333333333331607.0Topological domainCytoplasmic
HgeneROBO1chr3:78987751chr3:64008199ENST00000436010-229898_918127.333333333333331613.0TransmembraneHelical
HgeneROBO1chr3:78987751chr3:64008199ENST00000464233-431898_918166.333333333333341652.0TransmembraneHelical
HgeneROBO1chr3:78987751chr3:64008199ENST00000467549-229898_918127.333333333333331552.0TransmembraneHelical
HgeneROBO1chr3:78987751chr3:64008199ENST00000495273-229898_918127.333333333333331607.0TransmembraneHelical


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ROBO1
PSMD6


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to ROBO1-PSMD6


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to ROBO1-PSMD6


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource