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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ROBO2-ERLIN2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ROBO2-ERLIN2
FusionPDB ID: 75276
FusionGDB2.0 ID: 75276
HgeneTgene
Gene symbol

ROBO2

ERLIN2

Gene ID

6092

11160

Gene nameroundabout guidance receptor 2ER lipid raft associated 2
SynonymsSAX3C8orf2|Erlin-2|NET32|SPFH2|SPG18
Cytomap

3p12.3

8p11.23

Type of geneprotein-codingprotein-coding
Descriptionroundabout homolog 2roundabout, axon guidance receptor, homolog 2erlin-2SPFH domain family, member 2endoplasmic reticulum lipid raft-associated protein 2epididymis secretory sperm binding proteinspastic paraplegia 18 (autosomal dominant)stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2
Modification date2020031320200327
UniProtAcc.

O94905

Ensembl transtripts involved in fusion geneENST idsENST00000332191, ENST00000461745, 
ENST00000487694, ENST00000469233, 
ENST00000276461, ENST00000335171, 
ENST00000397228, ENST00000518586, 
ENST00000519638, ENST00000523107, 
ENST00000523887, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score20 X 20 X 4=16004 X 6 X 3=72
# samples 216
** MAII scorelog2(21/1600*10)=-2.9296106721086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ROBO2 [Title/Abstract] AND ERLIN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ROBO2(77147491)-ERLIN2(37602089), # samples:2
ROBO2(77147491)-ERLIN2(37607077), # samples:2
Anticipated loss of major functional domain due to fusion event.ROBO2-ERLIN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ROBO2-ERLIN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ROBO2-ERLIN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ROBO2-ERLIN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ROBO2-ERLIN2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ROBO2-ERLIN2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneROBO2

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

12504588

HgeneROBO2

GO:0050772

positive regulation of axonogenesis

12504588

HgeneROBO2

GO:0050925

negative regulation of negative chemotaxis

11748139

TgeneERLIN2

GO:0030433

ubiquitin-dependent ERAD pathway

19240031


check buttonFusion gene breakpoints across ROBO2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ERLIN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-56-6546-01AROBO2chr3

77147491

+ERLIN2chr8

37602089

+
ChimerDB4LUSCTCGA-56-6546-01AROBO2chr3

77147491

-ERLIN2chr8

37607077

+
ChimerDB4LUSCTCGA-56-6546ROBO2chr3

77147491

+ERLIN2chr8

37602088

+
ChimerDB4LUSCTCGA-56-6546ROBO2chr3

77147491

+ERLIN2chr8

37602089

+
ChimerDB4LUSCTCGA-56-6546ROBO2chr3

77147491

+ERLIN2chr8

37607077

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000487694ROBO2chr377147491+ENST00000397228ERLIN2chr837602089+1795715279875198
ENST00000487694ROBO2chr377147491+ENST00000276461ERLIN2chr837602089+64237152791436385
ENST00000487694ROBO2chr377147491+ENST00000335171ERLIN2chr837602089+1821715279875198
ENST00000487694ROBO2chr377147491+ENST00000519638ERLIN2chr837602089+17787152791436385
ENST00000461745ROBO2chr377147491+ENST00000397228ERLIN2chr837602089+236812889001448182
ENST00000461745ROBO2chr377147491+ENST00000276461ERLIN2chr837602089+699612889002009369
ENST00000461745ROBO2chr377147491+ENST00000335171ERLIN2chr837602089+239412889001448182
ENST00000461745ROBO2chr377147491+ENST00000519638ERLIN2chr837602089+235112889002009369
ENST00000332191ROBO2chr377147491+ENST00000397228ERLIN2chr837602089+152444456604182
ENST00000332191ROBO2chr377147491+ENST00000276461ERLIN2chr837602089+6152444561165369
ENST00000332191ROBO2chr377147491+ENST00000335171ERLIN2chr837602089+155044456604182
ENST00000332191ROBO2chr377147491+ENST00000519638ERLIN2chr837602089+1507444561165369
ENST00000487694ROBO2chr377147491+ENST00000397228ERLIN2chr837602088+1795715279875198
ENST00000487694ROBO2chr377147491+ENST00000276461ERLIN2chr837602088+64237152791436385
ENST00000487694ROBO2chr377147491+ENST00000335171ERLIN2chr837602088+1821715279875198
ENST00000487694ROBO2chr377147491+ENST00000519638ERLIN2chr837602088+17787152791436385
ENST00000461745ROBO2chr377147491+ENST00000397228ERLIN2chr837602088+236812889001448182
ENST00000461745ROBO2chr377147491+ENST00000276461ERLIN2chr837602088+699612889002009369
ENST00000461745ROBO2chr377147491+ENST00000335171ERLIN2chr837602088+239412889001448182
ENST00000461745ROBO2chr377147491+ENST00000519638ERLIN2chr837602088+235112889002009369
ENST00000332191ROBO2chr377147491+ENST00000397228ERLIN2chr837602088+152444456604182
ENST00000332191ROBO2chr377147491+ENST00000276461ERLIN2chr837602088+6152444561165369
ENST00000332191ROBO2chr377147491+ENST00000335171ERLIN2chr837602088+155044456604182
ENST00000332191ROBO2chr377147491+ENST00000519638ERLIN2chr837602088+1507444561165369

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000487694ENST00000397228ROBO2chr377147491+ERLIN2chr837602089+0.0018756130.9981244
ENST00000487694ENST00000276461ROBO2chr377147491+ERLIN2chr837602089+0.0006042850.9993957
ENST00000487694ENST00000335171ROBO2chr377147491+ERLIN2chr837602089+0.0017153820.99828464
ENST00000487694ENST00000519638ROBO2chr377147491+ERLIN2chr837602089+0.002946220.99705374
ENST00000461745ENST00000397228ROBO2chr377147491+ERLIN2chr837602089+0.0019281670.9980718
ENST00000461745ENST00000276461ROBO2chr377147491+ERLIN2chr837602089+0.000315820.9996842
ENST00000461745ENST00000335171ROBO2chr377147491+ERLIN2chr837602089+0.0018277590.9981723
ENST00000461745ENST00000519638ROBO2chr377147491+ERLIN2chr837602089+0.0009313390.9990687
ENST00000332191ENST00000397228ROBO2chr377147491+ERLIN2chr837602089+0.000592570.9994074
ENST00000332191ENST00000276461ROBO2chr377147491+ERLIN2chr837602089+0.0002799130.99972004
ENST00000332191ENST00000335171ROBO2chr377147491+ERLIN2chr837602089+0.0005835210.9994165
ENST00000332191ENST00000519638ROBO2chr377147491+ERLIN2chr837602089+0.0007026650.99929726
ENST00000487694ENST00000397228ROBO2chr377147491+ERLIN2chr837602088+0.0018756130.9981244
ENST00000487694ENST00000276461ROBO2chr377147491+ERLIN2chr837602088+0.0006042850.9993957
ENST00000487694ENST00000335171ROBO2chr377147491+ERLIN2chr837602088+0.0017153820.99828464
ENST00000487694ENST00000519638ROBO2chr377147491+ERLIN2chr837602088+0.002946220.99705374
ENST00000461745ENST00000397228ROBO2chr377147491+ERLIN2chr837602088+0.0019281670.9980718
ENST00000461745ENST00000276461ROBO2chr377147491+ERLIN2chr837602088+0.000315820.9996842
ENST00000461745ENST00000335171ROBO2chr377147491+ERLIN2chr837602088+0.0018277590.9981723
ENST00000461745ENST00000519638ROBO2chr377147491+ERLIN2chr837602088+0.0009313390.9990687
ENST00000332191ENST00000397228ROBO2chr377147491+ERLIN2chr837602088+0.000592570.9994074
ENST00000332191ENST00000276461ROBO2chr377147491+ERLIN2chr837602088+0.0002799130.99972004
ENST00000332191ENST00000335171ROBO2chr377147491+ERLIN2chr837602088+0.0005835210.9994165
ENST00000332191ENST00000519638ROBO2chr377147491+ERLIN2chr837602088+0.0007026650.99929726

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>75276_75276_1_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000332191_ERLIN2_chr8_37602088_ENST00000276461_length(amino acids)=369AA_BP=130
MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL
FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKL
ALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEK
KISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGSVSKQFEGLADKLSFGLEDE

--------------------------------------------------------------

>75276_75276_2_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000332191_ERLIN2_chr8_37602088_ENST00000335171_length(amino acids)=182AA_BP=130
MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL
FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFGLENDFSQE

--------------------------------------------------------------

>75276_75276_3_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000332191_ERLIN2_chr8_37602088_ENST00000397228_length(amino acids)=182AA_BP=130
MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL
FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFGLENDFSQE

--------------------------------------------------------------

>75276_75276_4_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000332191_ERLIN2_chr8_37602088_ENST00000519638_length(amino acids)=369AA_BP=130
MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL
FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKL
ALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEK
KISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGSVSKQFEGLADKLSFGLEDE

--------------------------------------------------------------

>75276_75276_5_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000332191_ERLIN2_chr8_37602089_ENST00000276461_length(amino acids)=369AA_BP=130
MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL
FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKL
ALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEK
KISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGSVSKQFEGLADKLSFGLEDE

--------------------------------------------------------------

>75276_75276_6_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000332191_ERLIN2_chr8_37602089_ENST00000335171_length(amino acids)=182AA_BP=130
MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL
FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFGLENDFSQE

--------------------------------------------------------------

>75276_75276_7_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000332191_ERLIN2_chr8_37602089_ENST00000397228_length(amino acids)=182AA_BP=130
MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL
FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFGLENDFSQE

--------------------------------------------------------------

>75276_75276_8_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000332191_ERLIN2_chr8_37602089_ENST00000519638_length(amino acids)=369AA_BP=130
MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL
FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKL
ALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEK
KISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGSVSKQFEGLADKLSFGLEDE

--------------------------------------------------------------

>75276_75276_9_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000461745_ERLIN2_chr8_37602088_ENST00000276461_length(amino acids)=369AA_BP=130
MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL
FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKL
ALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEK
KISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGSVSKQFEGLADKLSFGLEDE

--------------------------------------------------------------

>75276_75276_10_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000461745_ERLIN2_chr8_37602088_ENST00000335171_length(amino acids)=182AA_BP=130
MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL
FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFGLENDFSQE

--------------------------------------------------------------

>75276_75276_11_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000461745_ERLIN2_chr8_37602088_ENST00000397228_length(amino acids)=182AA_BP=130
MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL
FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFGLENDFSQE

--------------------------------------------------------------

>75276_75276_12_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000461745_ERLIN2_chr8_37602088_ENST00000519638_length(amino acids)=369AA_BP=130
MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL
FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKL
ALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEK
KISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGSVSKQFEGLADKLSFGLEDE

--------------------------------------------------------------

>75276_75276_13_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000461745_ERLIN2_chr8_37602089_ENST00000276461_length(amino acids)=369AA_BP=130
MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL
FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKL
ALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEK
KISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGSVSKQFEGLADKLSFGLEDE

--------------------------------------------------------------

>75276_75276_14_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000461745_ERLIN2_chr8_37602089_ENST00000335171_length(amino acids)=182AA_BP=130
MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL
FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFGLENDFSQE

--------------------------------------------------------------

>75276_75276_15_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000461745_ERLIN2_chr8_37602089_ENST00000397228_length(amino acids)=182AA_BP=130
MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL
FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFGLENDFSQE

--------------------------------------------------------------

>75276_75276_16_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000461745_ERLIN2_chr8_37602089_ENST00000519638_length(amino acids)=369AA_BP=130
MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL
FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKL
ALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEK
KISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGSVSKQFEGLADKLSFGLEDE

--------------------------------------------------------------

>75276_75276_17_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000487694_ERLIN2_chr8_37602088_ENST00000276461_length(amino acids)=385AA_BP=146
MARRHERVTRRMWTWAPGLLMMTVVFWGHQGNGQGQGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETD
KDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQ
EVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQV
AEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGSVSK

--------------------------------------------------------------

>75276_75276_18_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000487694_ERLIN2_chr8_37602088_ENST00000335171_length(amino acids)=198AA_BP=146
MARRHERVTRRMWTWAPGLLMMTVVFWGHQGNGQGQGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETD
KDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQ

--------------------------------------------------------------

>75276_75276_19_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000487694_ERLIN2_chr8_37602088_ENST00000397228_length(amino acids)=198AA_BP=146
MARRHERVTRRMWTWAPGLLMMTVVFWGHQGNGQGQGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETD
KDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQ

--------------------------------------------------------------

>75276_75276_20_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000487694_ERLIN2_chr8_37602088_ENST00000519638_length(amino acids)=385AA_BP=146
MARRHERVTRRMWTWAPGLLMMTVVFWGHQGNGQGQGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETD
KDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQ
EVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQV
AEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGSVSK

--------------------------------------------------------------

>75276_75276_21_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000487694_ERLIN2_chr8_37602089_ENST00000276461_length(amino acids)=385AA_BP=146
MARRHERVTRRMWTWAPGLLMMTVVFWGHQGNGQGQGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETD
KDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQ
EVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQV
AEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGSVSK

--------------------------------------------------------------

>75276_75276_22_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000487694_ERLIN2_chr8_37602089_ENST00000335171_length(amino acids)=198AA_BP=146
MARRHERVTRRMWTWAPGLLMMTVVFWGHQGNGQGQGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETD
KDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQ

--------------------------------------------------------------

>75276_75276_23_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000487694_ERLIN2_chr8_37602089_ENST00000397228_length(amino acids)=198AA_BP=146
MARRHERVTRRMWTWAPGLLMMTVVFWGHQGNGQGQGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETD
KDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQ

--------------------------------------------------------------

>75276_75276_24_ROBO2-ERLIN2_ROBO2_chr3_77147491_ENST00000487694_ERLIN2_chr8_37602089_ENST00000519638_length(amino acids)=385AA_BP=146
MARRHERVTRRMWTWAPGLLMMTVVFWGHQGNGQGQGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETD
KDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQ
EVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQV
AEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGSVSK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:77147491/chr8:37602089)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ERLIN2

O94905

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed:24217618). {ECO:0000269|PubMed:17502376, ECO:0000269|PubMed:19240031, ECO:0000269|PubMed:21343306, ECO:0000269|PubMed:24217618}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneROBO2chr3:77147491chr8:37602088ENST00000461745+22631_127129.333333333333341379.0DomainNote=Ig-like C2-type 1
HgeneROBO2chr3:77147491chr8:37602088ENST00000487694+32731_127145.333333333333341395.0DomainNote=Ig-like C2-type 1
HgeneROBO2chr3:77147491chr8:37602089ENST00000461745+22631_127129.333333333333341379.0DomainNote=Ig-like C2-type 1
HgeneROBO2chr3:77147491chr8:37602089ENST00000487694+32731_127145.333333333333341395.0DomainNote=Ig-like C2-type 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneROBO2chr3:77147491chr8:37602088ENST00000461745+226133_220129.333333333333341379.0DomainNote=Ig-like C2-type 2
HgeneROBO2chr3:77147491chr8:37602088ENST00000461745+226225_309129.333333333333341379.0DomainNote=Ig-like C2-type 3
HgeneROBO2chr3:77147491chr8:37602088ENST00000461745+226314_409129.333333333333341379.0DomainNote=Ig-like C2-type 4
HgeneROBO2chr3:77147491chr8:37602088ENST00000461745+226418_504129.333333333333341379.0DomainNote=Ig-like C2-type 5
HgeneROBO2chr3:77147491chr8:37602088ENST00000461745+226524_618129.333333333333341379.0DomainFibronectin type-III 1
HgeneROBO2chr3:77147491chr8:37602088ENST00000461745+226637_735129.333333333333341379.0DomainFibronectin type-III 2
HgeneROBO2chr3:77147491chr8:37602088ENST00000461745+226739_836129.333333333333341379.0DomainFibronectin type-III 3
HgeneROBO2chr3:77147491chr8:37602088ENST00000487694+327133_220145.333333333333341395.0DomainNote=Ig-like C2-type 2
HgeneROBO2chr3:77147491chr8:37602088ENST00000487694+327225_309145.333333333333341395.0DomainNote=Ig-like C2-type 3
HgeneROBO2chr3:77147491chr8:37602088ENST00000487694+327314_409145.333333333333341395.0DomainNote=Ig-like C2-type 4
HgeneROBO2chr3:77147491chr8:37602088ENST00000487694+327418_504145.333333333333341395.0DomainNote=Ig-like C2-type 5
HgeneROBO2chr3:77147491chr8:37602088ENST00000487694+327524_618145.333333333333341395.0DomainFibronectin type-III 1
HgeneROBO2chr3:77147491chr8:37602088ENST00000487694+327637_735145.333333333333341395.0DomainFibronectin type-III 2
HgeneROBO2chr3:77147491chr8:37602088ENST00000487694+327739_836145.333333333333341395.0DomainFibronectin type-III 3
HgeneROBO2chr3:77147491chr8:37602089ENST00000461745+226133_220129.333333333333341379.0DomainNote=Ig-like C2-type 2
HgeneROBO2chr3:77147491chr8:37602089ENST00000461745+226225_309129.333333333333341379.0DomainNote=Ig-like C2-type 3
HgeneROBO2chr3:77147491chr8:37602089ENST00000461745+226314_409129.333333333333341379.0DomainNote=Ig-like C2-type 4
HgeneROBO2chr3:77147491chr8:37602089ENST00000461745+226418_504129.333333333333341379.0DomainNote=Ig-like C2-type 5
HgeneROBO2chr3:77147491chr8:37602089ENST00000461745+226524_618129.333333333333341379.0DomainFibronectin type-III 1
HgeneROBO2chr3:77147491chr8:37602089ENST00000461745+226637_735129.333333333333341379.0DomainFibronectin type-III 2
HgeneROBO2chr3:77147491chr8:37602089ENST00000461745+226739_836129.333333333333341379.0DomainFibronectin type-III 3
HgeneROBO2chr3:77147491chr8:37602089ENST00000487694+327133_220145.333333333333341395.0DomainNote=Ig-like C2-type 2
HgeneROBO2chr3:77147491chr8:37602089ENST00000487694+327225_309145.333333333333341395.0DomainNote=Ig-like C2-type 3
HgeneROBO2chr3:77147491chr8:37602089ENST00000487694+327314_409145.333333333333341395.0DomainNote=Ig-like C2-type 4
HgeneROBO2chr3:77147491chr8:37602089ENST00000487694+327418_504145.333333333333341395.0DomainNote=Ig-like C2-type 5
HgeneROBO2chr3:77147491chr8:37602089ENST00000487694+327524_618145.333333333333341395.0DomainFibronectin type-III 1
HgeneROBO2chr3:77147491chr8:37602089ENST00000487694+327637_735145.333333333333341395.0DomainFibronectin type-III 2
HgeneROBO2chr3:77147491chr8:37602089ENST00000487694+327739_836145.333333333333341395.0DomainFibronectin type-III 3
HgeneROBO2chr3:77147491chr8:37602088ENST00000461745+22622_859129.333333333333341379.0Topological domainExtracellular
HgeneROBO2chr3:77147491chr8:37602088ENST00000461745+226881_1378129.333333333333341379.0Topological domainCytoplasmic
HgeneROBO2chr3:77147491chr8:37602088ENST00000487694+32722_859145.333333333333341395.0Topological domainExtracellular
HgeneROBO2chr3:77147491chr8:37602088ENST00000487694+327881_1378145.333333333333341395.0Topological domainCytoplasmic
HgeneROBO2chr3:77147491chr8:37602089ENST00000461745+22622_859129.333333333333341379.0Topological domainExtracellular
HgeneROBO2chr3:77147491chr8:37602089ENST00000461745+226881_1378129.333333333333341379.0Topological domainCytoplasmic
HgeneROBO2chr3:77147491chr8:37602089ENST00000487694+32722_859145.333333333333341395.0Topological domainExtracellular
HgeneROBO2chr3:77147491chr8:37602089ENST00000487694+327881_1378145.333333333333341395.0Topological domainCytoplasmic
HgeneROBO2chr3:77147491chr8:37602088ENST00000461745+226860_880129.333333333333341379.0TransmembraneHelical
HgeneROBO2chr3:77147491chr8:37602088ENST00000487694+327860_880145.333333333333341395.0TransmembraneHelical
HgeneROBO2chr3:77147491chr8:37602089ENST00000461745+226860_880129.333333333333341379.0TransmembraneHelical
HgeneROBO2chr3:77147491chr8:37602089ENST00000487694+327860_880145.333333333333341395.0TransmembraneHelical
TgeneERLIN2chr3:77147491chr8:37602088ENST000002764614121_399.33333333333333340.0Topological domainCytoplasmic
TgeneERLIN2chr3:77147491chr8:37602088ENST0000027646141225_33999.33333333333333340.0Topological domainLumenal
TgeneERLIN2chr3:77147491chr8:37602088ENST00000335171471_399.33333333333333153.0Topological domainCytoplasmic
TgeneERLIN2chr3:77147491chr8:37602088ENST000003351714725_33999.33333333333333153.0Topological domainLumenal
TgeneERLIN2chr3:77147491chr8:37602088ENST00000397228471_399.33333333333333153.0Topological domainCytoplasmic
TgeneERLIN2chr3:77147491chr8:37602088ENST000003972284725_33999.33333333333333153.0Topological domainLumenal
TgeneERLIN2chr3:77147491chr8:37602088ENST00000518586461_399.33333333333333207.0Topological domainCytoplasmic
TgeneERLIN2chr3:77147491chr8:37602088ENST000005185864625_33999.33333333333333207.0Topological domainLumenal
TgeneERLIN2chr3:77147491chr8:37602088ENST000005196383111_399.33333333333333340.0Topological domainCytoplasmic
TgeneERLIN2chr3:77147491chr8:37602088ENST0000051963831125_33999.33333333333333340.0Topological domainLumenal
TgeneERLIN2chr3:77147491chr8:37602088ENST00000523107461_399.33333333333333207.0Topological domainCytoplasmic
TgeneERLIN2chr3:77147491chr8:37602088ENST000005231074625_33999.33333333333333207.0Topological domainLumenal
TgeneERLIN2chr3:77147491chr8:37602088ENST00000523887461_399.33333333333333207.0Topological domainCytoplasmic
TgeneERLIN2chr3:77147491chr8:37602088ENST000005238874625_33999.33333333333333207.0Topological domainLumenal
TgeneERLIN2chr3:77147491chr8:37602089ENST000002764614121_399.33333333333333340.0Topological domainCytoplasmic
TgeneERLIN2chr3:77147491chr8:37602089ENST0000027646141225_33999.33333333333333340.0Topological domainLumenal
TgeneERLIN2chr3:77147491chr8:37602089ENST00000335171471_399.33333333333333153.0Topological domainCytoplasmic
TgeneERLIN2chr3:77147491chr8:37602089ENST000003351714725_33999.33333333333333153.0Topological domainLumenal
TgeneERLIN2chr3:77147491chr8:37602089ENST00000397228471_399.33333333333333153.0Topological domainCytoplasmic
TgeneERLIN2chr3:77147491chr8:37602089ENST000003972284725_33999.33333333333333153.0Topological domainLumenal
TgeneERLIN2chr3:77147491chr8:37602089ENST00000518586461_399.33333333333333207.0Topological domainCytoplasmic
TgeneERLIN2chr3:77147491chr8:37602089ENST000005185864625_33999.33333333333333207.0Topological domainLumenal
TgeneERLIN2chr3:77147491chr8:37602089ENST000005196383111_399.33333333333333340.0Topological domainCytoplasmic
TgeneERLIN2chr3:77147491chr8:37602089ENST0000051963831125_33999.33333333333333340.0Topological domainLumenal
TgeneERLIN2chr3:77147491chr8:37602089ENST00000523107461_399.33333333333333207.0Topological domainCytoplasmic
TgeneERLIN2chr3:77147491chr8:37602089ENST000005231074625_33999.33333333333333207.0Topological domainLumenal
TgeneERLIN2chr3:77147491chr8:37602089ENST00000523887461_399.33333333333333207.0Topological domainCytoplasmic
TgeneERLIN2chr3:77147491chr8:37602089ENST000005238874625_33999.33333333333333207.0Topological domainLumenal
TgeneERLIN2chr3:77147491chr8:37602088ENST000002764614124_2499.33333333333333340.0TransmembraneHelical
TgeneERLIN2chr3:77147491chr8:37602088ENST00000335171474_2499.33333333333333153.0TransmembraneHelical
TgeneERLIN2chr3:77147491chr8:37602088ENST00000397228474_2499.33333333333333153.0TransmembraneHelical
TgeneERLIN2chr3:77147491chr8:37602088ENST00000518586464_2499.33333333333333207.0TransmembraneHelical
TgeneERLIN2chr3:77147491chr8:37602088ENST000005196383114_2499.33333333333333340.0TransmembraneHelical
TgeneERLIN2chr3:77147491chr8:37602088ENST00000523107464_2499.33333333333333207.0TransmembraneHelical
TgeneERLIN2chr3:77147491chr8:37602088ENST00000523887464_2499.33333333333333207.0TransmembraneHelical
TgeneERLIN2chr3:77147491chr8:37602089ENST000002764614124_2499.33333333333333340.0TransmembraneHelical
TgeneERLIN2chr3:77147491chr8:37602089ENST00000335171474_2499.33333333333333153.0TransmembraneHelical
TgeneERLIN2chr3:77147491chr8:37602089ENST00000397228474_2499.33333333333333153.0TransmembraneHelical
TgeneERLIN2chr3:77147491chr8:37602089ENST00000518586464_2499.33333333333333207.0TransmembraneHelical
TgeneERLIN2chr3:77147491chr8:37602089ENST000005196383114_2499.33333333333333340.0TransmembraneHelical
TgeneERLIN2chr3:77147491chr8:37602089ENST00000523107464_2499.33333333333333207.0TransmembraneHelical
TgeneERLIN2chr3:77147491chr8:37602089ENST00000523887464_2499.33333333333333207.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ROBO2
ERLIN2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ROBO2-ERLIN2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ROBO2-ERLIN2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource