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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ATL2-DCTN1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ATL2-DCTN1
FusionPDB ID: 7643
FusionGDB2.0 ID: 7643
HgeneTgene
Gene symbol

ATL2

DCTN1

Gene ID

64225

1639

Gene nameatlastin GTPase 2dynactin subunit 1
SynonymsARL3IP2|ARL6IP2|aip-2|atlastin2DAP-150|DP-150|P135
Cytomap

2p22.2-p22.1

2p13.1

Type of geneprotein-codingprotein-coding
Descriptionatlastin-2ADP-ribosylation factor-like protein 6-interacting protein 2ARL-6-interacting protein 2dynactin subunit 1150 kDa dynein-associated polypeptidedynactin 1 (p150, glued homolog, Drosophila)
Modification date2020031320200319
UniProtAcc

Q8NHH9

Q14203

Ensembl transtripts involved in fusion geneENST idsENST00000332337, ENST00000378954, 
ENST00000419554, ENST00000452935, 
ENST00000402054, ENST00000406122, 
ENST00000486927, ENST00000539122, 
ENST00000546051, 		ENST00000409240, 
ENST00000409567, ENST00000409868, 
ENST00000407639, ENST00000409438, 
ENST00000495643, ENST00000361874, 
ENST00000394003, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 10 X 5=7008 X 9 X 3=216
# samples 169
** MAII scorelog2(16/700*10)=-2.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ATL2 [Title/Abstract] AND DCTN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ATL2(38570410)-DCTN1(74605372), # samples:1
Anticipated loss of major functional domain due to fusion event.ATL2-DCTN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATL2-DCTN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATL2-DCTN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATL2-DCTN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATL2

GO:0051260

protein homooligomerization

18270207

TgeneDCTN1

GO:0031116

positive regulation of microtubule polymerization

23874158

TgeneDCTN1

GO:0090063

positive regulation of microtubule nucleation

23874158


check buttonFusion gene breakpoints across ATL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DCTN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8295-01AATL2chr2

38570410

-DCTN1chr2

74605372

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000378954ATL2chr238570410-ENST00000394003DCTN1chr274605372-4493365241471381
ENST00000378954ATL2chr238570410-ENST00000361874DCTN1chr274605372-4514365241681388
ENST00000332337ATL2chr238570410-ENST00000394003DCTN1chr274605372-44823543341361367
ENST00000332337ATL2chr238570410-ENST00000361874DCTN1chr274605372-45033543341571374
ENST00000419554ATL2chr238570410-ENST00000394003DCTN1chr274605372-45043761341581381
ENST00000419554ATL2chr238570410-ENST00000361874DCTN1chr274605372-45253761341791388
ENST00000452935ATL2chr238570410-ENST00000394003DCTN1chr274605372-485272440345061367
ENST00000452935ATL2chr238570410-ENST00000361874DCTN1chr274605372-487372440345271374

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000378954ENST00000394003ATL2chr238570410-DCTN1chr274605372-0.012643650.9873563
ENST00000378954ENST00000361874ATL2chr238570410-DCTN1chr274605372-0.0126676680.9873323
ENST00000332337ENST00000394003ATL2chr238570410-DCTN1chr274605372-0.0113094940.9886905
ENST00000332337ENST00000361874ATL2chr238570410-DCTN1chr274605372-0.0113803260.9886197
ENST00000419554ENST00000394003ATL2chr238570410-DCTN1chr274605372-0.0125398360.98746014
ENST00000419554ENST00000361874ATL2chr238570410-DCTN1chr274605372-0.012586560.9874134
ENST00000452935ENST00000394003ATL2chr238570410-DCTN1chr274605372-0.0117702870.98822975
ENST00000452935ENST00000361874ATL2chr238570410-DCTN1chr274605372-0.0118353520.98816466

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>7643_7643_1_ATL2-DCTN1_ATL2_chr2_38570410_ENST00000332337_DCTN1_chr2_74605372_ENST00000361874_length(amino acids)=1374AA_BP=107
MKILMVLKKGIKFFQRLINSKSLRFGENYEDDDLVNSDEVMKKPCPVQIVLAHEDDHNFELDEEALEQILLQEHIRDLNIVVVSVAGAFR
KGKSFLLDFMLRYMYNKTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEG
HGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSAS
AGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSK
MQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGA
ASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT
DRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNREL
TNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRK
QAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDET
VNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRR
MPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCN
ILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAA
KDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIP
GQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLST
HTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAA

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>7643_7643_2_ATL2-DCTN1_ATL2_chr2_38570410_ENST00000332337_DCTN1_chr2_74605372_ENST00000394003_length(amino acids)=1367AA_BP=107
MKILMVLKKGIKFFQRLINSKSLRFGENYEDDDLVNSDEVMKKPCPVQIVLAHEDDHNFELDEEALEQILLQEHIRDLNIVVVSVAGAFR
KGKSFLLDFMLRYMYNKTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEG
HGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTSKLAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSS
EPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQAD
LQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLK
QLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLE
EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEAS
VERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFE
LSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT
KAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAP
GIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMN
KLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERI
EKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSV
PGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVDI
TRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHR

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>7643_7643_3_ATL2-DCTN1_ATL2_chr2_38570410_ENST00000378954_DCTN1_chr2_74605372_ENST00000361874_length(amino acids)=1388AA_BP=121
MAEGDEAARGQQPHQGLWRRRRTSDPSAAVNHVSSTTSLGENYEDDDLVNSDEVMKKPCPVQIVLAHEDDHNFELDEEALEQILLQEHIR
DLNIVVVSVAGAFRKGKSFLLDFMLRYMYNKTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKND
GTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGV
AGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK
HKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLE
ILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQV
DAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKY
RQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLL
LMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD
FLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETS
CSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGT
PSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEAN
VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLV
SGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYR
KTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQD

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>7643_7643_4_ATL2-DCTN1_ATL2_chr2_38570410_ENST00000378954_DCTN1_chr2_74605372_ENST00000394003_length(amino acids)=1381AA_BP=121
MAEGDEAARGQQPHQGLWRRRRTSDPSAAVNHVSSTTSLGENYEDDDLVNSDEVMKKPCPVQIVLAHEDDHNFELDEEALEQILLQEHIR
DLNIVVVSVAGAFRKGKSFLLDFMLRYMYNKTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKND
GTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTSKLAPTARKTTTRRPKPTRPASTGVAGASSSL
GPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ
VQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIE
EKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAE
EMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHL
QDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLIC
KAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLH
KDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQF
CKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYE
CLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLE
KKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEE
QQRGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLE
TLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGK

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>7643_7643_5_ATL2-DCTN1_ATL2_chr2_38570410_ENST00000419554_DCTN1_chr2_74605372_ENST00000361874_length(amino acids)=1388AA_BP=121
MAEGDEAARGQQPHQGLWRRRRTSDPSAAVNHVSSTTSLGENYEDDDLVNSDEVMKKPCPVQIVLAHEDDHNFELDEEALEQILLQEHIR
DLNIVVVSVAGAFRKGKSFLLDFMLRYMYNKTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKND
GTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGV
AGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK
HKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLE
ILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQV
DAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKY
RQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLL
LMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD
FLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETS
CSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGT
PSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEAN
VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLV
SGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYR
KTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQD

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>7643_7643_6_ATL2-DCTN1_ATL2_chr2_38570410_ENST00000419554_DCTN1_chr2_74605372_ENST00000394003_length(amino acids)=1381AA_BP=121
MAEGDEAARGQQPHQGLWRRRRTSDPSAAVNHVSSTTSLGENYEDDDLVNSDEVMKKPCPVQIVLAHEDDHNFELDEEALEQILLQEHIR
DLNIVVVSVAGAFRKGKSFLLDFMLRYMYNKTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKND
GTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTSKLAPTARKTTTRRPKPTRPASTGVAGASSSL
GPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ
VQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIE
EKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAE
EMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHL
QDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLIC
KAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLH
KDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQF
CKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYE
CLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLE
KKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEE
QQRGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLE
TLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGK

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>7643_7643_7_ATL2-DCTN1_ATL2_chr2_38570410_ENST00000452935_DCTN1_chr2_74605372_ENST00000361874_length(amino acids)=1374AA_BP=107
MKILMVLKKGIKFFQRLINSKSLRFGENYEDDDLVNSDEVMKKPCPVQIVLAHEDDHNFELDEEALEQILLQEHIRDLNIVVVSVAGAFR
KGKSFLLDFMLRYMYNKTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEG
HGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSAS
AGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSK
MQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGA
ASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT
DRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNREL
TNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRK
QAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDET
VNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRR
MPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCN
ILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAA
KDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIP
GQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLST
HTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAA

--------------------------------------------------------------

>7643_7643_8_ATL2-DCTN1_ATL2_chr2_38570410_ENST00000452935_DCTN1_chr2_74605372_ENST00000394003_length(amino acids)=1367AA_BP=107
MKILMVLKKGIKFFQRLINSKSLRFGENYEDDDLVNSDEVMKKPCPVQIVLAHEDDHNFELDEEALEQILLQEHIRDLNIVVVSVAGAFR
KGKSFLLDFMLRYMYNKTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEG
HGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTSKLAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSS
EPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQAD
LQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLK
QLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLE
EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEAS
VERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFE
LSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT
KAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAP
GIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMN
KLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERI
EKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSV
PGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVDI
TRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHR

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:38570410/chr2:74605372)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATL2

Q8NHH9

DCTN1

Q14203

FUNCTION: GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed:18270207, PubMed:19665976, PubMed:27619977). {ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:19665976, ECO:0000269|PubMed:27619977}.FUNCTION: Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATL2chr2:38570410chr2:74605372ENST00000378954-213101_108121.0584.0Nucleotide bindingGTP
HgeneATL2chr2:38570410chr2:74605372ENST00000419554-213101_108121.0580.0Nucleotide bindingGTP
TgeneDCTN1chr2:38570410chr2:74605372ENST000003618740321182_121111.01279.0Coiled coilOntology_term=ECO:0000255
TgeneDCTN1chr2:38570410chr2:74605372ENST00000361874032213_54711.01279.0Coiled coilOntology_term=ECO:0000255
TgeneDCTN1chr2:38570410chr2:74605372ENST00000361874032943_104911.01279.0Coiled coilOntology_term=ECO:0000255
TgeneDCTN1chr2:38570410chr2:74605372ENST000003940030311182_121111.01272.0Coiled coilOntology_term=ECO:0000255
TgeneDCTN1chr2:38570410chr2:74605372ENST00000394003031213_54711.01272.0Coiled coilOntology_term=ECO:0000255
TgeneDCTN1chr2:38570410chr2:74605372ENST00000394003031943_104911.01272.0Coiled coilOntology_term=ECO:0000255
TgeneDCTN1chr2:38570410chr2:74605372ENST000004076390271182_121101145.0Coiled coilOntology_term=ECO:0000255
TgeneDCTN1chr2:38570410chr2:74605372ENST00000407639027213_54701145.0Coiled coilOntology_term=ECO:0000255
TgeneDCTN1chr2:38570410chr2:74605372ENST00000407639027943_104901145.0Coiled coilOntology_term=ECO:0000255
TgeneDCTN1chr2:38570410chr2:74605372ENST000004092400281182_121101237.0Coiled coilOntology_term=ECO:0000255
TgeneDCTN1chr2:38570410chr2:74605372ENST00000409240028213_54701237.0Coiled coilOntology_term=ECO:0000255
TgeneDCTN1chr2:38570410chr2:74605372ENST00000409240028943_104901237.0Coiled coilOntology_term=ECO:0000255
TgeneDCTN1chr2:38570410chr2:74605372ENST000004094380261182_121101140.0Coiled coilOntology_term=ECO:0000255
TgeneDCTN1chr2:38570410chr2:74605372ENST00000409438026213_54701140.0Coiled coilOntology_term=ECO:0000255
TgeneDCTN1chr2:38570410chr2:74605372ENST00000409438026943_104901140.0Coiled coilOntology_term=ECO:0000255
TgeneDCTN1chr2:38570410chr2:74605372ENST000004095670281182_121111.01254.0Coiled coilOntology_term=ECO:0000255
TgeneDCTN1chr2:38570410chr2:74605372ENST00000409567028213_54711.01254.0Coiled coilOntology_term=ECO:0000255
TgeneDCTN1chr2:38570410chr2:74605372ENST00000409567028943_104911.01254.0Coiled coilOntology_term=ECO:0000255
TgeneDCTN1chr2:38570410chr2:74605372ENST00000361874032164_19111.01279.0Compositional biasNote=Ser-rich
TgeneDCTN1chr2:38570410chr2:74605372ENST00000394003031164_19111.01272.0Compositional biasNote=Ser-rich
TgeneDCTN1chr2:38570410chr2:74605372ENST00000407639027164_19101145.0Compositional biasNote=Ser-rich
TgeneDCTN1chr2:38570410chr2:74605372ENST00000409240028164_19101237.0Compositional biasNote=Ser-rich
TgeneDCTN1chr2:38570410chr2:74605372ENST00000409438026164_19101140.0Compositional biasNote=Ser-rich
TgeneDCTN1chr2:38570410chr2:74605372ENST00000409567028164_19111.01254.0Compositional biasNote=Ser-rich
TgeneDCTN1chr2:38570410chr2:74605372ENST0000036187403248_9011.01279.0DomainCAP-Gly
TgeneDCTN1chr2:38570410chr2:74605372ENST0000039400303148_9011.01272.0DomainCAP-Gly
TgeneDCTN1chr2:38570410chr2:74605372ENST0000040763902748_9001145.0DomainCAP-Gly
TgeneDCTN1chr2:38570410chr2:74605372ENST0000040924002848_9001237.0DomainCAP-Gly
TgeneDCTN1chr2:38570410chr2:74605372ENST0000040943802648_9001140.0DomainCAP-Gly
TgeneDCTN1chr2:38570410chr2:74605372ENST0000040956702848_9011.01254.0DomainCAP-Gly

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATL2chr2:38570410chr2:74605372ENST00000332337-214256_284103.0567.0Coiled coilOntology_term=ECO:0000255
HgeneATL2chr2:38570410chr2:74605372ENST00000378954-213256_284121.0584.0Coiled coilOntology_term=ECO:0000255
HgeneATL2chr2:38570410chr2:74605372ENST00000402054-112256_2840413.0Coiled coilOntology_term=ECO:0000255
HgeneATL2chr2:38570410chr2:74605372ENST00000419554-213256_284121.0580.0Coiled coilOntology_term=ECO:0000255
HgeneATL2chr2:38570410chr2:74605372ENST00000539122-112256_2840413.0Coiled coilOntology_term=ECO:0000255
HgeneATL2chr2:38570410chr2:74605372ENST00000332337-21491_336103.0567.0DomainGB1/RHD3-type G
HgeneATL2chr2:38570410chr2:74605372ENST00000378954-21391_336121.0584.0DomainGB1/RHD3-type G
HgeneATL2chr2:38570410chr2:74605372ENST00000402054-11291_3360413.0DomainGB1/RHD3-type G
HgeneATL2chr2:38570410chr2:74605372ENST00000419554-21391_336121.0580.0DomainGB1/RHD3-type G
HgeneATL2chr2:38570410chr2:74605372ENST00000539122-11291_3360413.0DomainGB1/RHD3-type G
HgeneATL2chr2:38570410chr2:74605372ENST00000332337-214101_108103.0567.0Nucleotide bindingGTP
HgeneATL2chr2:38570410chr2:74605372ENST00000332337-214145_147103.0567.0Nucleotide bindingGTP
HgeneATL2chr2:38570410chr2:74605372ENST00000332337-214244_245103.0567.0Nucleotide bindingGTP
HgeneATL2chr2:38570410chr2:74605372ENST00000332337-214303_306103.0567.0Nucleotide bindingGTP
HgeneATL2chr2:38570410chr2:74605372ENST00000378954-213145_147121.0584.0Nucleotide bindingGTP
HgeneATL2chr2:38570410chr2:74605372ENST00000378954-213244_245121.0584.0Nucleotide bindingGTP
HgeneATL2chr2:38570410chr2:74605372ENST00000378954-213303_306121.0584.0Nucleotide bindingGTP
HgeneATL2chr2:38570410chr2:74605372ENST00000402054-112101_1080413.0Nucleotide bindingGTP
HgeneATL2chr2:38570410chr2:74605372ENST00000402054-112145_1470413.0Nucleotide bindingGTP
HgeneATL2chr2:38570410chr2:74605372ENST00000402054-112244_2450413.0Nucleotide bindingGTP
HgeneATL2chr2:38570410chr2:74605372ENST00000402054-112303_3060413.0Nucleotide bindingGTP
HgeneATL2chr2:38570410chr2:74605372ENST00000419554-213145_147121.0580.0Nucleotide bindingGTP
HgeneATL2chr2:38570410chr2:74605372ENST00000419554-213244_245121.0580.0Nucleotide bindingGTP
HgeneATL2chr2:38570410chr2:74605372ENST00000419554-213303_306121.0580.0Nucleotide bindingGTP
HgeneATL2chr2:38570410chr2:74605372ENST00000539122-112101_1080413.0Nucleotide bindingGTP
HgeneATL2chr2:38570410chr2:74605372ENST00000539122-112145_1470413.0Nucleotide bindingGTP
HgeneATL2chr2:38570410chr2:74605372ENST00000539122-112244_2450413.0Nucleotide bindingGTP
HgeneATL2chr2:38570410chr2:74605372ENST00000539122-112303_3060413.0Nucleotide bindingGTP
HgeneATL2chr2:38570410chr2:74605372ENST00000332337-2141_476103.0567.0Topological domainCytoplasmic
HgeneATL2chr2:38570410chr2:74605372ENST00000332337-214498_499103.0567.0Topological domainLumenal
HgeneATL2chr2:38570410chr2:74605372ENST00000332337-214521_583103.0567.0Topological domainCytoplasmic
HgeneATL2chr2:38570410chr2:74605372ENST00000378954-2131_476121.0584.0Topological domainCytoplasmic
HgeneATL2chr2:38570410chr2:74605372ENST00000378954-213498_499121.0584.0Topological domainLumenal
HgeneATL2chr2:38570410chr2:74605372ENST00000378954-213521_583121.0584.0Topological domainCytoplasmic
HgeneATL2chr2:38570410chr2:74605372ENST00000402054-1121_4760413.0Topological domainCytoplasmic
HgeneATL2chr2:38570410chr2:74605372ENST00000402054-112498_4990413.0Topological domainLumenal
HgeneATL2chr2:38570410chr2:74605372ENST00000402054-112521_5830413.0Topological domainCytoplasmic
HgeneATL2chr2:38570410chr2:74605372ENST00000419554-2131_476121.0580.0Topological domainCytoplasmic
HgeneATL2chr2:38570410chr2:74605372ENST00000419554-213498_499121.0580.0Topological domainLumenal
HgeneATL2chr2:38570410chr2:74605372ENST00000419554-213521_583121.0580.0Topological domainCytoplasmic
HgeneATL2chr2:38570410chr2:74605372ENST00000539122-1121_4760413.0Topological domainCytoplasmic
HgeneATL2chr2:38570410chr2:74605372ENST00000539122-112498_4990413.0Topological domainLumenal
HgeneATL2chr2:38570410chr2:74605372ENST00000539122-112521_5830413.0Topological domainCytoplasmic
HgeneATL2chr2:38570410chr2:74605372ENST00000332337-214477_497103.0567.0TransmembraneHelical
HgeneATL2chr2:38570410chr2:74605372ENST00000332337-214500_520103.0567.0TransmembraneHelical
HgeneATL2chr2:38570410chr2:74605372ENST00000378954-213477_497121.0584.0TransmembraneHelical
HgeneATL2chr2:38570410chr2:74605372ENST00000378954-213500_520121.0584.0TransmembraneHelical
HgeneATL2chr2:38570410chr2:74605372ENST00000402054-112477_4970413.0TransmembraneHelical
HgeneATL2chr2:38570410chr2:74605372ENST00000402054-112500_5200413.0TransmembraneHelical
HgeneATL2chr2:38570410chr2:74605372ENST00000419554-213477_497121.0580.0TransmembraneHelical
HgeneATL2chr2:38570410chr2:74605372ENST00000419554-213500_520121.0580.0TransmembraneHelical
HgeneATL2chr2:38570410chr2:74605372ENST00000539122-112477_4970413.0TransmembraneHelical
HgeneATL2chr2:38570410chr2:74605372ENST00000539122-112500_5200413.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
DCTN1HAP1, GSTK1, BZW1, AKTIP, RFXANK, BBS4, VIM, DYNC1H1, DST, PLK1, KIF11, PAFAH1B1, RAB6A, GRB2, EPB41, SPTBN1, STAT1, FBXL5, MED14, Cep76, Actr1a, Dctn1, Dctn3, Capza1, Dctn2, DISC1, DTNBP1, DYNC1I1, NEK2, KIAA0408, CDC37, AKT1, PFDN1, PPP1CA, KIAA0368, CUL3, DYNLL1, DCTN1, DCTN2, SAP30BP, POLR2B, MCM3, RNF168, FLNC, MCCC1, RANBP9, STRN4, RBL2, SMURF1, Ccdc64, Ccdc64b, PEX14, ZNF512B, BBS1, FBXW4, MTERF1, LGR4, BICD2, DYNC1LI1, Bicd2, MAPT, MOV10, NXF1, CAPZA2, ACTR1B, CYFIP1, ACTR1A, CAPZB, CC2D1B, CCAR1, DCTN4, DNAJA2, DYNC1I2, PSMB6, PSMD11, SF3A3, SF3B3, EIF2A, PACSIN3, POP1, NTRK1, HSPB2, CEP170, NIN, ACTR10, AGK, AURKB, BTF3, BTF3L4, KNSTRN, TMEM256, CAMSAP2, CCNB1, CKAP2, CKAP2L, CLASP1, CLTC, CPVL, DCLK1, DCTN3, DCTN6, DNM2, EBNA1BP2, EML1, EML4, ERLIN2, FDXR, GPATCH1, GTSE1, HAUS8, HMMR, HYOU1, IGF2BP2, IPO7, IPO9, CEP170B, KIF2A, LASP1, LONP1, LUZP1, MAP1LC3B, MAP1S, MAP2, MAP7, MAP7D1, MAP7D2, MAP7D3, MAP9, MAPRE1, MAPRE2, MAPRE3, MTUS1, NAP1L1, NAP1L4, NMT1, NNT, NUBP2, PLEKHA5, PSMD14, PSMD7, RAB2A, RAB35, RAB8A, SDHC, SKA2, SKA3, SPAG5, SRSF2, EMC3, TRIM36, TSFM, UQCRC1, ZC3H15, ZNF622, ABRACL, ANXA1, ARHGEF2, HYPK, CAMSAP1, CC2D1A, CCDC124, CEP41, CEP44, CHTOP, CLASP2, CLIP1, DCDC2, DCLK2, DCTN5, DLGAP5, DVL1, FAM83D, GAS2L3, GPX1, HAUS4, HAUS6, HAUS7, CFAP97, KIF14, KIF2C, LSM14B, LTV1, MARK2, STK26, MTPN, NAA10, NAA15, NACA, NDC80, NDUFA5, NEBL, NEDD1, NPLOC4, PAPOLG, PDZD11, PRC1, SKA1, SLAIN2, SPC24, SRP9, SUPT16H, TBCEL, TDRD3, TSR1, TTF2, TTK, UPF1, YTHDC2, YTHDF1, YTHDF2, ZC2HC1A, DYNLT1, MYO19, SEC16A, TRIM29, Myo1c, Actr1b, Coro1c, Dctn5, Dynlrb1, Dctn4, Kctd5, Cenpe, Dync1li1, IRF3, SNW1, DCDC5, MYO6, DUSP12, DUSP13, KLHL2, MIPEP, RIC8A, DSTYK, C1orf106, PDGFD, RPS19BP1, C16orf45, ACTA2, CAPZA1, NINL, AHI1, CAMK2A, CYLD, TRIM25, UBE2A, HEY1, BRCA1, TES, WWC1, CFTR, ZNF598, EGLN3, PCBP1, UBE2M, EFTUD2, TNIP2, ESR2, NOD2, HEXIM1, MEPCE, LARP7, RNF181, MYC, HIST1H4A, HIST1H2BB, GRWD1, KIAA1429, ACTC1, GBF1, DYNC1LI2, DYNLRB1, CCDC88C, CCDC88A, HOOK3, HOOK1, APEX1, BIRC3, STAU1, KIAA1107, TRIM28, PLEKHA4, ENO3, TP53RK, CIT, KIF20A, FASN, SPHK2, Apc2, ORF6, CUL4A, HSPA12B, DDX58, UFL1, ABCF3, ANKRD28, ANKRD52, APC, ARHGAP21, CAMSAP3, CCSER2, CDC27, CENPE, CENPJ, CEP131, CEP162, CEP290, CEP350, CEP55, CEP72, DHX57, DNAJC21, EDF1, ESPL1, FAM161A, GEN1, GKAP1, JAKMIP1, MACF1, MAP1A, MAP4, MPHOSPH9, NAV1, NCKAP5L, NUF2, PPP6R1, PRR36, PSRC1, SH3PXD2B, SLAIN1, SOGA1, SPECC1, SPECC1L, SPICE1, SYNJ2, TMEM79, TRIM26, TTN, TUBB3, TXNL1, UBE2O, WDR62, ZC3H7A, CCDC138, DHX29, DIAPH3, ENSA, HAUS5, IBTK, IFT74, IPO8, KIAA1217, KIF1B, KIF7, OFD1, PAK4, PDLIM3, SH3D19, UPF3B, FZR1, FXR1, HOXA1, NAA40, SEPT14, ZKSCAN1, MAPK8IP3, FBXW7, CTIF, EEF1A1, BAG3, HDAC6, FBXO32, MISP,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ATL2
DCTN1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ATL2-DCTN1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ATL2-DCTN1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDCTN1C1868594Perry Syndrome11CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneDCTN1C1843315Neuronopathy, Distal Hereditary Motor, Type Viib8CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneDCTN1C1862939AMYOTROPHIC LATERAL SCLEROSIS 16CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneDCTN1C0002736Amyotrophic Lateral Sclerosis1ORPHANET
TgeneDCTN1C0242422Parkinsonian Disorders1CTD_human
TgeneDCTN1C0242423Ramsay Hunt Paralysis Syndrome1CTD_human
TgeneDCTN1C0525045Mood Disorders1CTD_human
TgeneDCTN1C0752097Autosomal Dominant Juvenile Parkinson Disease1CTD_human
TgeneDCTN1C0752098Autosomal Dominant Parkinsonism1CTD_human
TgeneDCTN1C0752100Autosomal Recessive Parkinsonism1CTD_human
TgeneDCTN1C0752101Parkinsonism, Experimental1CTD_human
TgeneDCTN1C0752104Familial Juvenile Parkinsonism1CTD_human
TgeneDCTN1C0752105Parkinsonism, Juvenile1CTD_human
TgeneDCTN1C1868675PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE1CTD_human
TgeneDCTN1C3203358Hypoventilation1CTD_human
TgeneDCTN1C4749653Distal hereditary motor neuropathy type 71ORPHANET