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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ATP11A-DHRS12

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ATP11A-DHRS12
FusionPDB ID: 7711
FusionGDB2.0 ID: 7711
HgeneTgene
Gene symbol

ATP11A

DHRS12

Gene ID

23250

79758

Gene nameATPase phospholipid transporting 11Adehydrogenase/reductase 12
SynonymsATPIH|ATPISSDR40C1
Cytomap

13q34

13q14.3

Type of geneprotein-codingprotein-coding
Descriptionprobable phospholipid-transporting ATPase IHATPase, class VI, type 11AP4-ATPase flippase complex alpha subunit ATP11Aphospholipid-translocating ATPasepotential phospholipid-transporting ATPase IHdehydrogenase/reductase SDR family member 12dehydrogenase/reductase (SDR family) member 12short-chain dehydrogenase/reductase family 40C member 1
Modification date2020031320200313
UniProtAcc

Q6ZP68

A0PJE2

Ensembl transtripts involved in fusion geneENST idsENST00000283558, ENST00000375630, 
ENST00000375645, ENST00000487903, 
ENST00000419448, 		ENST00000490949, 
ENST00000218981, ENST00000280056, 
ENST00000444610, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score20 X 11 X 16=35204 X 3 X 3=36
# samples 315
** MAII scorelog2(31/3520*10)=-3.50523530825042
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ATP11A [Title/Abstract] AND DHRS12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ATP11A(113516889)-DHRS12(52365393), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ATP11A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DHRS12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-YL-A8SQ-01BATP11Achr13

113516889

-DHRS12chr13

52365393

-
ChimerDB4PRADTCGA-YL-A8SQ-01BATP11Achr13

113516889

+DHRS12chr13

52365393

-
ChimerDB4PRADTCGA-YL-A8SQATP11Achr13

113516889

+DHRS12chr13

52365393

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000283558ATP11Achr13113516889+ENST00000444610DHRS12chr1352365393-395430795537591234
ENST00000283558ATP11Achr13113516889+ENST00000218981DHRS12chr1352365393-481130795536811208
ENST00000283558ATP11Achr13113516889+ENST00000280056DHRS12chr1352365393-422430795537681237
ENST00000375630ATP11Achr13113516889+ENST00000444610DHRS12chr1352365393-395430795537591234
ENST00000375630ATP11Achr13113516889+ENST00000218981DHRS12chr1352365393-481130795536811208
ENST00000375630ATP11Achr13113516889+ENST00000280056DHRS12chr1352365393-422430795537681237
ENST00000487903ATP11Achr13113516889+ENST00000444610DHRS12chr1352365393-395430795537591234
ENST00000487903ATP11Achr13113516889+ENST00000218981DHRS12chr1352365393-481130795536811208
ENST00000487903ATP11Achr13113516889+ENST00000280056DHRS12chr1352365393-422430795537681237
ENST00000375645ATP11Achr13113516889+ENST00000444610DHRS12chr1352365393-395430795537591234
ENST00000375645ATP11Achr13113516889+ENST00000218981DHRS12chr1352365393-481130795536811208
ENST00000375645ATP11Achr13113516889+ENST00000280056DHRS12chr1352365393-422430795537681237

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000283558ENST00000444610ATP11Achr13113516889+DHRS12chr1352365393-0.000889880.99911004
ENST00000283558ENST00000218981ATP11Achr13113516889+DHRS12chr1352365393-0.0012083740.99879164
ENST00000283558ENST00000280056ATP11Achr13113516889+DHRS12chr1352365393-0.0012838010.99871624
ENST00000375630ENST00000444610ATP11Achr13113516889+DHRS12chr1352365393-0.000889880.99911004
ENST00000375630ENST00000218981ATP11Achr13113516889+DHRS12chr1352365393-0.0012083740.99879164
ENST00000375630ENST00000280056ATP11Achr13113516889+DHRS12chr1352365393-0.0012838010.99871624
ENST00000487903ENST00000444610ATP11Achr13113516889+DHRS12chr1352365393-0.000889880.99911004
ENST00000487903ENST00000218981ATP11Achr13113516889+DHRS12chr1352365393-0.0012083740.99879164
ENST00000487903ENST00000280056ATP11Achr13113516889+DHRS12chr1352365393-0.0012838010.99871624
ENST00000375645ENST00000444610ATP11Achr13113516889+DHRS12chr1352365393-0.000889880.99911004
ENST00000375645ENST00000218981ATP11Achr13113516889+DHRS12chr1352365393-0.0012083740.99879164
ENST00000375645ENST00000280056ATP11Achr13113516889+DHRS12chr1352365393-0.0012838010.99871624

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>7711_7711_1_ATP11A-DHRS12_ATP11A_chr13_113516889_ENST00000283558_DHRS12_chr13_52365393_ENST00000218981_length(amino acids)=1208AA_BP=1008
MNGGAGAAGGAMDCSLVRTLVHRYCAGEENWVDSRTIYVGHREPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLI
IFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSS
NRGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDIGGLHATIECEQPQPDLYKFVGRINVYSDLNDPVVRPLGSENLLLRGATLKNT
EKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNAFLIVYLCILISKALINTVLKYMWQSEPFRDEPWYNQKTESERQRNLFLKAFTDF
LAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMEFKECCIEGHVYVPH
VICNGQVLPESSGIDMIDSSPSVNGREREELFFRALCLCHTVQVKDDDSVDGPRKSPDGGKSCVYISSSPDEVALVEGVQRLGFTYLRLK
DNYMEILNRENHIERFELLEILSFDSVRRRMSVIVKSATGEIYLFCKGADSSIFPRVIEGKVDQIRARVERNAVEGLRTLCVAYKRLIQE
EYEGICKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETAAATCYACKLFRRNTQ
LLELTTKRIEEQSLHDVLFELSKTVLRHSGSLTRDNLSGLSADMQDYGLIIDGAALSLIMKPREDGSSGNYRELFLEICRSCSAVLCCRM
APLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYK
NVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDVAKNALLRWRVFIYWTLLGLFDALVF
FFGAYFVFENTTVTSNGQNIFLHIVDLSDPKQIWKFVENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLE
KEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHPGWADTPGVRQAMPGFHARFGDRLR

--------------------------------------------------------------

>7711_7711_2_ATP11A-DHRS12_ATP11A_chr13_113516889_ENST00000283558_DHRS12_chr13_52365393_ENST00000280056_length(amino acids)=1237AA_BP=1008
MNGGAGAAGGAMDCSLVRTLVHRYCAGEENWVDSRTIYVGHREPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLI
IFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSS
NRGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDIGGLHATIECEQPQPDLYKFVGRINVYSDLNDPVVRPLGSENLLLRGATLKNT
EKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNAFLIVYLCILISKALINTVLKYMWQSEPFRDEPWYNQKTESERQRNLFLKAFTDF
LAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMEFKECCIEGHVYVPH
VICNGQVLPESSGIDMIDSSPSVNGREREELFFRALCLCHTVQVKDDDSVDGPRKSPDGGKSCVYISSSPDEVALVEGVQRLGFTYLRLK
DNYMEILNRENHIERFELLEILSFDSVRRRMSVIVKSATGEIYLFCKGADSSIFPRVIEGKVDQIRARVERNAVEGLRTLCVAYKRLIQE
EYEGICKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETAAATCYACKLFRRNTQ
LLELTTKRIEEQSLHDVLFELSKTVLRHSGSLTRDNLSGLSADMQDYGLIIDGAALSLIMKPREDGSSGNYRELFLEICRSCSAVLCCRM
APLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYK
NVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDVAKNALLRWRVFIYWTLLGLFDALVF
FFGAYFVFENTTVTSNGQNIFLHIVDLSDPKQIWKFVENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLE
KEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHPGWADTPDRNEQELRKVVGEAQTAS

--------------------------------------------------------------

>7711_7711_3_ATP11A-DHRS12_ATP11A_chr13_113516889_ENST00000283558_DHRS12_chr13_52365393_ENST00000444610_length(amino acids)=1234AA_BP=1008
MNGGAGAAGGAMDCSLVRTLVHRYCAGEENWVDSRTIYVGHREPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLI
IFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSS
NRGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDIGGLHATIECEQPQPDLYKFVGRINVYSDLNDPVVRPLGSENLLLRGATLKNT
EKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNAFLIVYLCILISKALINTVLKYMWQSEPFRDEPWYNQKTESERQRNLFLKAFTDF
LAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMEFKECCIEGHVYVPH
VICNGQVLPESSGIDMIDSSPSVNGREREELFFRALCLCHTVQVKDDDSVDGPRKSPDGGKSCVYISSSPDEVALVEGVQRLGFTYLRLK
DNYMEILNRENHIERFELLEILSFDSVRRRMSVIVKSATGEIYLFCKGADSSIFPRVIEGKVDQIRARVERNAVEGLRTLCVAYKRLIQE
EYEGICKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETAAATCYACKLFRRNTQ
LLELTTKRIEEQSLHDVLFELSKTVLRHSGSLTRDNLSGLSADMQDYGLIIDGAALSLIMKPREDGSSGNYRELFLEICRSCSAVLCCRM
APLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYK
NVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDVAKNALLRWRVFIYWTLLGLFDALVF
FFGAYFVFENTTVTSNGQNIFLHIVDLSDPKQIWKFVENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLE
KEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHPGWADTPGVRQAMPGFHARFGDRLR

--------------------------------------------------------------

>7711_7711_4_ATP11A-DHRS12_ATP11A_chr13_113516889_ENST00000375630_DHRS12_chr13_52365393_ENST00000218981_length(amino acids)=1208AA_BP=1008
MNGGAGAAGGAMDCSLVRTLVHRYCAGEENWVDSRTIYVGHREPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLI
IFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSS
NRGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDIGGLHATIECEQPQPDLYKFVGRINVYSDLNDPVVRPLGSENLLLRGATLKNT
EKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNAFLIVYLCILISKALINTVLKYMWQSEPFRDEPWYNQKTESERQRNLFLKAFTDF
LAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMEFKECCIEGHVYVPH
VICNGQVLPESSGIDMIDSSPSVNGREREELFFRALCLCHTVQVKDDDSVDGPRKSPDGGKSCVYISSSPDEVALVEGVQRLGFTYLRLK
DNYMEILNRENHIERFELLEILSFDSVRRRMSVIVKSATGEIYLFCKGADSSIFPRVIEGKVDQIRARVERNAVEGLRTLCVAYKRLIQE
EYEGICKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETAAATCYACKLFRRNTQ
LLELTTKRIEEQSLHDVLFELSKTVLRHSGSLTRDNLSGLSADMQDYGLIIDGAALSLIMKPREDGSSGNYRELFLEICRSCSAVLCCRM
APLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYK
NVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDVAKNALLRWRVFIYWTLLGLFDALVF
FFGAYFVFENTTVTSNGQNIFLHIVDLSDPKQIWKFVENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLE
KEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHPGWADTPGVRQAMPGFHARFGDRLR

--------------------------------------------------------------

>7711_7711_5_ATP11A-DHRS12_ATP11A_chr13_113516889_ENST00000375630_DHRS12_chr13_52365393_ENST00000280056_length(amino acids)=1237AA_BP=1008
MNGGAGAAGGAMDCSLVRTLVHRYCAGEENWVDSRTIYVGHREPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLI
IFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSS
NRGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDIGGLHATIECEQPQPDLYKFVGRINVYSDLNDPVVRPLGSENLLLRGATLKNT
EKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNAFLIVYLCILISKALINTVLKYMWQSEPFRDEPWYNQKTESERQRNLFLKAFTDF
LAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMEFKECCIEGHVYVPH
VICNGQVLPESSGIDMIDSSPSVNGREREELFFRALCLCHTVQVKDDDSVDGPRKSPDGGKSCVYISSSPDEVALVEGVQRLGFTYLRLK
DNYMEILNRENHIERFELLEILSFDSVRRRMSVIVKSATGEIYLFCKGADSSIFPRVIEGKVDQIRARVERNAVEGLRTLCVAYKRLIQE
EYEGICKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETAAATCYACKLFRRNTQ
LLELTTKRIEEQSLHDVLFELSKTVLRHSGSLTRDNLSGLSADMQDYGLIIDGAALSLIMKPREDGSSGNYRELFLEICRSCSAVLCCRM
APLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYK
NVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDVAKNALLRWRVFIYWTLLGLFDALVF
FFGAYFVFENTTVTSNGQNIFLHIVDLSDPKQIWKFVENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLE
KEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHPGWADTPDRNEQELRKVVGEAQTAS

--------------------------------------------------------------

>7711_7711_6_ATP11A-DHRS12_ATP11A_chr13_113516889_ENST00000375630_DHRS12_chr13_52365393_ENST00000444610_length(amino acids)=1234AA_BP=1008
MNGGAGAAGGAMDCSLVRTLVHRYCAGEENWVDSRTIYVGHREPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLI
IFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSS
NRGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDIGGLHATIECEQPQPDLYKFVGRINVYSDLNDPVVRPLGSENLLLRGATLKNT
EKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNAFLIVYLCILISKALINTVLKYMWQSEPFRDEPWYNQKTESERQRNLFLKAFTDF
LAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMEFKECCIEGHVYVPH
VICNGQVLPESSGIDMIDSSPSVNGREREELFFRALCLCHTVQVKDDDSVDGPRKSPDGGKSCVYISSSPDEVALVEGVQRLGFTYLRLK
DNYMEILNRENHIERFELLEILSFDSVRRRMSVIVKSATGEIYLFCKGADSSIFPRVIEGKVDQIRARVERNAVEGLRTLCVAYKRLIQE
EYEGICKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETAAATCYACKLFRRNTQ
LLELTTKRIEEQSLHDVLFELSKTVLRHSGSLTRDNLSGLSADMQDYGLIIDGAALSLIMKPREDGSSGNYRELFLEICRSCSAVLCCRM
APLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYK
NVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDVAKNALLRWRVFIYWTLLGLFDALVF
FFGAYFVFENTTVTSNGQNIFLHIVDLSDPKQIWKFVENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLE
KEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHPGWADTPGVRQAMPGFHARFGDRLR

--------------------------------------------------------------

>7711_7711_7_ATP11A-DHRS12_ATP11A_chr13_113516889_ENST00000375645_DHRS12_chr13_52365393_ENST00000218981_length(amino acids)=1208AA_BP=1008
MNGGAGAAGGAMDCSLVRTLVHRYCAGEENWVDSRTIYVGHREPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLI
IFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSS
NRGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDIGGLHATIECEQPQPDLYKFVGRINVYSDLNDPVVRPLGSENLLLRGATLKNT
EKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNAFLIVYLCILISKALINTVLKYMWQSEPFRDEPWYNQKTESERQRNLFLKAFTDF
LAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMEFKECCIEGHVYVPH
VICNGQVLPESSGIDMIDSSPSVNGREREELFFRALCLCHTVQVKDDDSVDGPRKSPDGGKSCVYISSSPDEVALVEGVQRLGFTYLRLK
DNYMEILNRENHIERFELLEILSFDSVRRRMSVIVKSATGEIYLFCKGADSSIFPRVIEGKVDQIRARVERNAVEGLRTLCVAYKRLIQE
EYEGICKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETAAATCYACKLFRRNTQ
LLELTTKRIEEQSLHDVLFELSKTVLRHSGSLTRDNLSGLSADMQDYGLIIDGAALSLIMKPREDGSSGNYRELFLEICRSCSAVLCCRM
APLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYK
NVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDVAKNALLRWRVFIYWTLLGLFDALVF
FFGAYFVFENTTVTSNGQNIFLHIVDLSDPKQIWKFVENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLE
KEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHPGWADTPGVRQAMPGFHARFGDRLR

--------------------------------------------------------------

>7711_7711_8_ATP11A-DHRS12_ATP11A_chr13_113516889_ENST00000375645_DHRS12_chr13_52365393_ENST00000280056_length(amino acids)=1237AA_BP=1008
MNGGAGAAGGAMDCSLVRTLVHRYCAGEENWVDSRTIYVGHREPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLI
IFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSS
NRGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDIGGLHATIECEQPQPDLYKFVGRINVYSDLNDPVVRPLGSENLLLRGATLKNT
EKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNAFLIVYLCILISKALINTVLKYMWQSEPFRDEPWYNQKTESERQRNLFLKAFTDF
LAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMEFKECCIEGHVYVPH
VICNGQVLPESSGIDMIDSSPSVNGREREELFFRALCLCHTVQVKDDDSVDGPRKSPDGGKSCVYISSSPDEVALVEGVQRLGFTYLRLK
DNYMEILNRENHIERFELLEILSFDSVRRRMSVIVKSATGEIYLFCKGADSSIFPRVIEGKVDQIRARVERNAVEGLRTLCVAYKRLIQE
EYEGICKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETAAATCYACKLFRRNTQ
LLELTTKRIEEQSLHDVLFELSKTVLRHSGSLTRDNLSGLSADMQDYGLIIDGAALSLIMKPREDGSSGNYRELFLEICRSCSAVLCCRM
APLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYK
NVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDVAKNALLRWRVFIYWTLLGLFDALVF
FFGAYFVFENTTVTSNGQNIFLHIVDLSDPKQIWKFVENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLE
KEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHPGWADTPDRNEQELRKVVGEAQTAS

--------------------------------------------------------------

>7711_7711_9_ATP11A-DHRS12_ATP11A_chr13_113516889_ENST00000375645_DHRS12_chr13_52365393_ENST00000444610_length(amino acids)=1234AA_BP=1008
MNGGAGAAGGAMDCSLVRTLVHRYCAGEENWVDSRTIYVGHREPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLI
IFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSS
NRGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDIGGLHATIECEQPQPDLYKFVGRINVYSDLNDPVVRPLGSENLLLRGATLKNT
EKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNAFLIVYLCILISKALINTVLKYMWQSEPFRDEPWYNQKTESERQRNLFLKAFTDF
LAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMEFKECCIEGHVYVPH
VICNGQVLPESSGIDMIDSSPSVNGREREELFFRALCLCHTVQVKDDDSVDGPRKSPDGGKSCVYISSSPDEVALVEGVQRLGFTYLRLK
DNYMEILNRENHIERFELLEILSFDSVRRRMSVIVKSATGEIYLFCKGADSSIFPRVIEGKVDQIRARVERNAVEGLRTLCVAYKRLIQE
EYEGICKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETAAATCYACKLFRRNTQ
LLELTTKRIEEQSLHDVLFELSKTVLRHSGSLTRDNLSGLSADMQDYGLIIDGAALSLIMKPREDGSSGNYRELFLEICRSCSAVLCCRM
APLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYK
NVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDVAKNALLRWRVFIYWTLLGLFDALVF
FFGAYFVFENTTVTSNGQNIFLHIVDLSDPKQIWKFVENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLE
KEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHPGWADTPGVRQAMPGFHARFGDRLR

--------------------------------------------------------------

>7711_7711_10_ATP11A-DHRS12_ATP11A_chr13_113516889_ENST00000487903_DHRS12_chr13_52365393_ENST00000218981_length(amino acids)=1208AA_BP=1008
MNGGAGAAGGAMDCSLVRTLVHRYCAGEENWVDSRTIYVGHREPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLI
IFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSS
NRGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDIGGLHATIECEQPQPDLYKFVGRINVYSDLNDPVVRPLGSENLLLRGATLKNT
EKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNAFLIVYLCILISKALINTVLKYMWQSEPFRDEPWYNQKTESERQRNLFLKAFTDF
LAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMEFKECCIEGHVYVPH
VICNGQVLPESSGIDMIDSSPSVNGREREELFFRALCLCHTVQVKDDDSVDGPRKSPDGGKSCVYISSSPDEVALVEGVQRLGFTYLRLK
DNYMEILNRENHIERFELLEILSFDSVRRRMSVIVKSATGEIYLFCKGADSSIFPRVIEGKVDQIRARVERNAVEGLRTLCVAYKRLIQE
EYEGICKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETAAATCYACKLFRRNTQ
LLELTTKRIEEQSLHDVLFELSKTVLRHSGSLTRDNLSGLSADMQDYGLIIDGAALSLIMKPREDGSSGNYRELFLEICRSCSAVLCCRM
APLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYK
NVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDVAKNALLRWRVFIYWTLLGLFDALVF
FFGAYFVFENTTVTSNGQNIFLHIVDLSDPKQIWKFVENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLE
KEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHPGWADTPGVRQAMPGFHARFGDRLR

--------------------------------------------------------------

>7711_7711_11_ATP11A-DHRS12_ATP11A_chr13_113516889_ENST00000487903_DHRS12_chr13_52365393_ENST00000280056_length(amino acids)=1237AA_BP=1008
MNGGAGAAGGAMDCSLVRTLVHRYCAGEENWVDSRTIYVGHREPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLI
IFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSS
NRGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDIGGLHATIECEQPQPDLYKFVGRINVYSDLNDPVVRPLGSENLLLRGATLKNT
EKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNAFLIVYLCILISKALINTVLKYMWQSEPFRDEPWYNQKTESERQRNLFLKAFTDF
LAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMEFKECCIEGHVYVPH
VICNGQVLPESSGIDMIDSSPSVNGREREELFFRALCLCHTVQVKDDDSVDGPRKSPDGGKSCVYISSSPDEVALVEGVQRLGFTYLRLK
DNYMEILNRENHIERFELLEILSFDSVRRRMSVIVKSATGEIYLFCKGADSSIFPRVIEGKVDQIRARVERNAVEGLRTLCVAYKRLIQE
EYEGICKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETAAATCYACKLFRRNTQ
LLELTTKRIEEQSLHDVLFELSKTVLRHSGSLTRDNLSGLSADMQDYGLIIDGAALSLIMKPREDGSSGNYRELFLEICRSCSAVLCCRM
APLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYK
NVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDVAKNALLRWRVFIYWTLLGLFDALVF
FFGAYFVFENTTVTSNGQNIFLHIVDLSDPKQIWKFVENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLE
KEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHPGWADTPDRNEQELRKVVGEAQTAS

--------------------------------------------------------------

>7711_7711_12_ATP11A-DHRS12_ATP11A_chr13_113516889_ENST00000487903_DHRS12_chr13_52365393_ENST00000444610_length(amino acids)=1234AA_BP=1008
MNGGAGAAGGAMDCSLVRTLVHRYCAGEENWVDSRTIYVGHREPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLI
IFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSS
NRGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDIGGLHATIECEQPQPDLYKFVGRINVYSDLNDPVVRPLGSENLLLRGATLKNT
EKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNAFLIVYLCILISKALINTVLKYMWQSEPFRDEPWYNQKTESERQRNLFLKAFTDF
LAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMEFKECCIEGHVYVPH
VICNGQVLPESSGIDMIDSSPSVNGREREELFFRALCLCHTVQVKDDDSVDGPRKSPDGGKSCVYISSSPDEVALVEGVQRLGFTYLRLK
DNYMEILNRENHIERFELLEILSFDSVRRRMSVIVKSATGEIYLFCKGADSSIFPRVIEGKVDQIRARVERNAVEGLRTLCVAYKRLIQE
EYEGICKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETAAATCYACKLFRRNTQ
LLELTTKRIEEQSLHDVLFELSKTVLRHSGSLTRDNLSGLSADMQDYGLIIDGAALSLIMKPREDGSSGNYRELFLEICRSCSAVLCCRM
APLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYK
NVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDVAKNALLRWRVFIYWTLLGLFDALVF
FFGAYFVFENTTVTSNGQNIFLHIVDLSDPKQIWKFVENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLE
KEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHPGWADTPGVRQAMPGFHARFGDRLR

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:113516889/chr13:52365393)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP11A

Q6ZP68

DHRS12

A0PJE2

FUNCTION: Putative oxidoreductase. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP11Achr13:113516889chr13:52365393ENST00000283558+2529111_296997.01135.0Topological domainCytoplasmic
HgeneATP11Achr13:113516889chr13:52365393ENST00000283558+25291_61997.01135.0Topological domainCytoplasmic
HgeneATP11Achr13:113516889chr13:52365393ENST00000283558+2529319_349997.01135.0Topological domainExtracellular
HgeneATP11Achr13:113516889chr13:52365393ENST00000283558+2529373_881997.01135.0Topological domainCytoplasmic
HgeneATP11Achr13:113516889chr13:52365393ENST00000283558+252983_88997.01135.0Topological domainExtracellular
HgeneATP11Achr13:113516889chr13:52365393ENST00000283558+2529903_914997.01135.0Topological domainExtracellular
HgeneATP11Achr13:113516889chr13:52365393ENST00000283558+2529935_964997.01135.0Topological domainCytoplasmic
HgeneATP11Achr13:113516889chr13:52365393ENST00000283558+2529987_1000997.01135.0Topological domainExtracellular
HgeneATP11Achr13:113516889chr13:52365393ENST00000375645+2530111_296997.02857.0Topological domainCytoplasmic
HgeneATP11Achr13:113516889chr13:52365393ENST00000375645+25301_61997.02857.0Topological domainCytoplasmic
HgeneATP11Achr13:113516889chr13:52365393ENST00000375645+2530319_349997.02857.0Topological domainExtracellular
HgeneATP11Achr13:113516889chr13:52365393ENST00000375645+2530373_881997.02857.0Topological domainCytoplasmic
HgeneATP11Achr13:113516889chr13:52365393ENST00000375645+253083_88997.02857.0Topological domainExtracellular
HgeneATP11Achr13:113516889chr13:52365393ENST00000375645+2530903_914997.02857.0Topological domainExtracellular
HgeneATP11Achr13:113516889chr13:52365393ENST00000375645+2530935_964997.02857.0Topological domainCytoplasmic
HgeneATP11Achr13:113516889chr13:52365393ENST00000375645+2530987_1000997.02857.0Topological domainExtracellular
HgeneATP11Achr13:113516889chr13:52365393ENST00000487903+2530111_296997.02878.0Topological domainCytoplasmic
HgeneATP11Achr13:113516889chr13:52365393ENST00000487903+25301_61997.02878.0Topological domainCytoplasmic
HgeneATP11Achr13:113516889chr13:52365393ENST00000487903+2530319_349997.02878.0Topological domainExtracellular
HgeneATP11Achr13:113516889chr13:52365393ENST00000487903+2530373_881997.02878.0Topological domainCytoplasmic
HgeneATP11Achr13:113516889chr13:52365393ENST00000487903+253083_88997.02878.0Topological domainExtracellular
HgeneATP11Achr13:113516889chr13:52365393ENST00000487903+2530903_914997.02878.0Topological domainExtracellular
HgeneATP11Achr13:113516889chr13:52365393ENST00000487903+2530935_964997.02878.0Topological domainCytoplasmic
HgeneATP11Achr13:113516889chr13:52365393ENST00000487903+2530987_1000997.02878.0Topological domainExtracellular
HgeneATP11Achr13:113516889chr13:52365393ENST00000283558+2529297_318997.01135.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000283558+2529350_372997.01135.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000283558+252962_82997.01135.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000283558+2529882_902997.01135.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000283558+252989_110997.01135.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000283558+2529915_934997.01135.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000283558+2529965_986997.01135.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000375645+2530297_318997.02857.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000375645+2530350_372997.02857.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000375645+253062_82997.02857.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000375645+2530882_902997.02857.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000375645+253089_110997.02857.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000375645+2530915_934997.02857.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000375645+2530965_986997.02857.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000487903+2530297_318997.02878.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000487903+2530350_372997.02878.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000487903+253062_82997.02878.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000487903+2530882_902997.02878.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000487903+253089_110997.02878.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000487903+2530915_934997.02878.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000487903+2530965_986997.02878.0TransmembraneHelical
TgeneDHRS12chr13:113516889chr13:52365393ENST000002189811847_5342.0243.0Nucleotide bindingNAD or NADP
TgeneDHRS12chr13:113516889chr13:52365393ENST000002800561847_5342.0272.0Nucleotide bindingNAD or NADP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP11Achr13:113516889chr13:52365393ENST00000283558+25291024_1029997.01135.0Topological domainCytoplasmic
HgeneATP11Achr13:113516889chr13:52365393ENST00000283558+25291051_1068997.01135.0Topological domainExtracellular
HgeneATP11Achr13:113516889chr13:52365393ENST00000283558+25291094_1134997.01135.0Topological domainCytoplasmic
HgeneATP11Achr13:113516889chr13:52365393ENST00000375645+25301024_1029997.02857.0Topological domainCytoplasmic
HgeneATP11Achr13:113516889chr13:52365393ENST00000375645+25301051_1068997.02857.0Topological domainExtracellular
HgeneATP11Achr13:113516889chr13:52365393ENST00000375645+25301094_1134997.02857.0Topological domainCytoplasmic
HgeneATP11Achr13:113516889chr13:52365393ENST00000487903+25301024_1029997.02878.0Topological domainCytoplasmic
HgeneATP11Achr13:113516889chr13:52365393ENST00000487903+25301051_1068997.02878.0Topological domainExtracellular
HgeneATP11Achr13:113516889chr13:52365393ENST00000487903+25301094_1134997.02878.0Topological domainCytoplasmic
HgeneATP11Achr13:113516889chr13:52365393ENST00000283558+25291001_1023997.01135.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000283558+25291030_1050997.01135.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000283558+25291069_1093997.01135.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000375645+25301001_1023997.02857.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000375645+25301030_1050997.02857.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000375645+25301069_1093997.02857.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000487903+25301001_1023997.02878.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000487903+25301030_1050997.02878.0TransmembraneHelical
HgeneATP11Achr13:113516889chr13:52365393ENST00000487903+25301069_1093997.02878.0TransmembraneHelical
TgeneDHRS12chr13:113516889chr13:52365393ENST0000044461021047_5391.0318.0Nucleotide bindingNAD or NADP


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1953_ATP11A_113516889_DHRS12_52365393_ranked_0.pdbATP11A113516889113516889ENST00000280056DHRS12chr1352365393-
MNGGAGAAGGAMDCSLVRTLVHRYCAGEENWVDSRTIYVGHREPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLI
IFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSS
NRGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDIGGLHATIECEQPQPDLYKFVGRINVYSDLNDPVVRPLGSENLLLRGATLKNT
EKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNAFLIVYLCILISKALINTVLKYMWQSEPFRDEPWYNQKTESERQRNLFLKAFTDF
LAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMEFKECCIEGHVYVPH
VICNGQVLPESSGIDMIDSSPSVNGREREELFFRALCLCHTVQVKDDDSVDGPRKSPDGGKSCVYISSSPDEVALVEGVQRLGFTYLRLK
DNYMEILNRENHIERFELLEILSFDSVRRRMSVIVKSATGEIYLFCKGADSSIFPRVIEGKVDQIRARVERNAVEGLRTLCVAYKRLIQE
EYEGICKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETAAATCYACKLFRRNTQ
LLELTTKRIEEQSLHDVLFELSKTVLRHSGSLTRDNLSGLSADMQDYGLIIDGAALSLIMKPREDGSSGNYRELFLEICRSCSAVLCCRM
APLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYK
NVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDVAKNALLRWRVFIYWTLLGLFDALVF
FFGAYFVFENTTVTSNGQNIFLHIVDLSDPKQIWKFVENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLE
KEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHPGWADTPDRNEQELRKVVGEAQTAS
1237


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ATP11A_pLDDT.png
all structure
all structure
DHRS12_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ATP11A
DHRS12


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ATP11A-DHRS12


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ATP11A-DHRS12


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource