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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ATP11A-NUCB2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ATP11A-NUCB2
FusionPDB ID: 7717
FusionGDB2.0 ID: 7717
HgeneTgene
Gene symbol

ATP11A

NUCB2

Gene ID

23250

4925

Gene nameATPase phospholipid transporting 11Anucleobindin 2
SynonymsATPIH|ATPISHEL-S-109|NEFA
Cytomap

13q34

11p15.1

Type of geneprotein-codingprotein-coding
Descriptionprobable phospholipid-transporting ATPase IHATPase, class VI, type 11AP4-ATPase flippase complex alpha subunit ATP11Aphospholipid-translocating ATPasepotential phospholipid-transporting ATPase IHnucleobindin-2DNA-binding protein NEFAepididymis secretory protein Li 109gastric cancer antigen Zg4nesfatin 1novel DNA binding/EF-hand/leucine zipper proteinnucleobinding 2prepronesfatin
Modification date2020031320200329
UniProtAcc

Q6ZP68

.
Ensembl transtripts involved in fusion geneENST idsENST00000283558, ENST00000375630, 
ENST00000375645, ENST00000487903, 
ENST00000419448, 		ENST00000532240, 
ENST00000323688, ENST00000458064, 
ENST00000529010, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score20 X 11 X 16=352011 X 12 X 4=528
# samples 3113
** MAII scorelog2(31/3520*10)=-3.50523530825042
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/528*10)=-2.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ATP11A [Title/Abstract] AND NUCB2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ATP11A(113344769)-NUCB2(17351673), # samples:1
Anticipated loss of major functional domain due to fusion event.ATP11A-NUCB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP11A-NUCB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ATP11A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NUCB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-29-2428ATP11Achr13

113344769

+NUCB2chr11

17351673

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000283558ATP11Achr13113344769+ENST00000323688NUCB2chr1117351673+78712755387110
ENST00000283558ATP11Achr13113344769+ENST00000529010NUCB2chr1117351673+118012755387110
ENST00000283558ATP11Achr13113344769+ENST00000458064NUCB2chr1117351673+41912755387110
ENST00000375630ATP11Achr13113344769+ENST00000323688NUCB2chr1117351673+78712755387110
ENST00000375630ATP11Achr13113344769+ENST00000529010NUCB2chr1117351673+118012755387110
ENST00000375630ATP11Achr13113344769+ENST00000458064NUCB2chr1117351673+41912755387110
ENST00000487903ATP11Achr13113344769+ENST00000323688NUCB2chr1117351673+78712755387110
ENST00000487903ATP11Achr13113344769+ENST00000529010NUCB2chr1117351673+118012755387110
ENST00000487903ATP11Achr13113344769+ENST00000458064NUCB2chr1117351673+41912755387110
ENST00000375645ATP11Achr13113344769+ENST00000323688NUCB2chr1117351673+78712755387110
ENST00000375645ATP11Achr13113344769+ENST00000529010NUCB2chr1117351673+118012755387110
ENST00000375645ATP11Achr13113344769+ENST00000458064NUCB2chr1117351673+41912755387110

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000283558ENST00000323688ATP11Achr13113344769+NUCB2chr1117351673+0.0270831450.9729169
ENST00000283558ENST00000529010ATP11Achr13113344769+NUCB2chr1117351673+0.0106334060.9893666
ENST00000283558ENST00000458064ATP11Achr13113344769+NUCB2chr1117351673+0.0240935960.9759064
ENST00000375630ENST00000323688ATP11Achr13113344769+NUCB2chr1117351673+0.0270831450.9729169
ENST00000375630ENST00000529010ATP11Achr13113344769+NUCB2chr1117351673+0.0106334060.9893666
ENST00000375630ENST00000458064ATP11Achr13113344769+NUCB2chr1117351673+0.0240935960.9759064
ENST00000487903ENST00000323688ATP11Achr13113344769+NUCB2chr1117351673+0.0270831450.9729169
ENST00000487903ENST00000529010ATP11Achr13113344769+NUCB2chr1117351673+0.0106334060.9893666
ENST00000487903ENST00000458064ATP11Achr13113344769+NUCB2chr1117351673+0.0240935960.9759064
ENST00000375645ENST00000323688ATP11Achr13113344769+NUCB2chr1117351673+0.0270831450.9729169
ENST00000375645ENST00000529010ATP11Achr13113344769+NUCB2chr1117351673+0.0106334060.9893666
ENST00000375645ENST00000458064ATP11Achr13113344769+NUCB2chr1117351673+0.0240935960.9759064

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>7717_7717_1_ATP11A-NUCB2_ATP11A_chr13_113344769_ENST00000283558_NUCB2_chr11_17351673_ENST00000323688_length(amino acids)=110AA_BP=24
MNGGAGAAGGAMDCSLVRTLVHRYTLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKK

--------------------------------------------------------------

>7717_7717_2_ATP11A-NUCB2_ATP11A_chr13_113344769_ENST00000283558_NUCB2_chr11_17351673_ENST00000458064_length(amino acids)=110AA_BP=24
MNGGAGAAGGAMDCSLVRTLVHRYTLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKK

--------------------------------------------------------------

>7717_7717_3_ATP11A-NUCB2_ATP11A_chr13_113344769_ENST00000283558_NUCB2_chr11_17351673_ENST00000529010_length(amino acids)=110AA_BP=24
MNGGAGAAGGAMDCSLVRTLVHRYTLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKK

--------------------------------------------------------------

>7717_7717_4_ATP11A-NUCB2_ATP11A_chr13_113344769_ENST00000375630_NUCB2_chr11_17351673_ENST00000323688_length(amino acids)=110AA_BP=24
MNGGAGAAGGAMDCSLVRTLVHRYTLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKK

--------------------------------------------------------------

>7717_7717_5_ATP11A-NUCB2_ATP11A_chr13_113344769_ENST00000375630_NUCB2_chr11_17351673_ENST00000458064_length(amino acids)=110AA_BP=24
MNGGAGAAGGAMDCSLVRTLVHRYTLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKK

--------------------------------------------------------------

>7717_7717_6_ATP11A-NUCB2_ATP11A_chr13_113344769_ENST00000375630_NUCB2_chr11_17351673_ENST00000529010_length(amino acids)=110AA_BP=24
MNGGAGAAGGAMDCSLVRTLVHRYTLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKK

--------------------------------------------------------------

>7717_7717_7_ATP11A-NUCB2_ATP11A_chr13_113344769_ENST00000375645_NUCB2_chr11_17351673_ENST00000323688_length(amino acids)=110AA_BP=24
MNGGAGAAGGAMDCSLVRTLVHRYTLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKK

--------------------------------------------------------------

>7717_7717_8_ATP11A-NUCB2_ATP11A_chr13_113344769_ENST00000375645_NUCB2_chr11_17351673_ENST00000458064_length(amino acids)=110AA_BP=24
MNGGAGAAGGAMDCSLVRTLVHRYTLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKK

--------------------------------------------------------------

>7717_7717_9_ATP11A-NUCB2_ATP11A_chr13_113344769_ENST00000375645_NUCB2_chr11_17351673_ENST00000529010_length(amino acids)=110AA_BP=24
MNGGAGAAGGAMDCSLVRTLVHRYTLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKK

--------------------------------------------------------------

>7717_7717_10_ATP11A-NUCB2_ATP11A_chr13_113344769_ENST00000487903_NUCB2_chr11_17351673_ENST00000323688_length(amino acids)=110AA_BP=24
MNGGAGAAGGAMDCSLVRTLVHRYTLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKK

--------------------------------------------------------------

>7717_7717_11_ATP11A-NUCB2_ATP11A_chr13_113344769_ENST00000487903_NUCB2_chr11_17351673_ENST00000458064_length(amino acids)=110AA_BP=24
MNGGAGAAGGAMDCSLVRTLVHRYTLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKK

--------------------------------------------------------------

>7717_7717_12_ATP11A-NUCB2_ATP11A_chr13_113344769_ENST00000487903_NUCB2_chr11_17351673_ENST00000529010_length(amino acids)=110AA_BP=24
MNGGAGAAGGAMDCSLVRTLVHRYTLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:113344769/chr11:17351673)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP11A

Q6ZP68

.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP11Achr13:113344769chr11:17351673ENST00000283558+1291024_102913.01135.0Topological domainCytoplasmic
HgeneATP11Achr13:113344769chr11:17351673ENST00000283558+1291051_106813.01135.0Topological domainExtracellular
HgeneATP11Achr13:113344769chr11:17351673ENST00000283558+1291094_113413.01135.0Topological domainCytoplasmic
HgeneATP11Achr13:113344769chr11:17351673ENST00000283558+129111_29613.01135.0Topological domainCytoplasmic
HgeneATP11Achr13:113344769chr11:17351673ENST00000283558+1291_6113.01135.0Topological domainCytoplasmic
HgeneATP11Achr13:113344769chr11:17351673ENST00000283558+129319_34913.01135.0Topological domainExtracellular
HgeneATP11Achr13:113344769chr11:17351673ENST00000283558+129373_88113.01135.0Topological domainCytoplasmic
HgeneATP11Achr13:113344769chr11:17351673ENST00000283558+12983_8813.01135.0Topological domainExtracellular
HgeneATP11Achr13:113344769chr11:17351673ENST00000283558+129903_91413.01135.0Topological domainExtracellular
HgeneATP11Achr13:113344769chr11:17351673ENST00000283558+129935_96413.01135.0Topological domainCytoplasmic
HgeneATP11Achr13:113344769chr11:17351673ENST00000283558+129987_100013.01135.0Topological domainExtracellular
HgeneATP11Achr13:113344769chr11:17351673ENST00000375645+1301024_102913.02857.0Topological domainCytoplasmic
HgeneATP11Achr13:113344769chr11:17351673ENST00000375645+1301051_106813.02857.0Topological domainExtracellular
HgeneATP11Achr13:113344769chr11:17351673ENST00000375645+1301094_113413.02857.0Topological domainCytoplasmic
HgeneATP11Achr13:113344769chr11:17351673ENST00000375645+130111_29613.02857.0Topological domainCytoplasmic
HgeneATP11Achr13:113344769chr11:17351673ENST00000375645+1301_6113.02857.0Topological domainCytoplasmic
HgeneATP11Achr13:113344769chr11:17351673ENST00000375645+130319_34913.02857.0Topological domainExtracellular
HgeneATP11Achr13:113344769chr11:17351673ENST00000375645+130373_88113.02857.0Topological domainCytoplasmic
HgeneATP11Achr13:113344769chr11:17351673ENST00000375645+13083_8813.02857.0Topological domainExtracellular
HgeneATP11Achr13:113344769chr11:17351673ENST00000375645+130903_91413.02857.0Topological domainExtracellular
HgeneATP11Achr13:113344769chr11:17351673ENST00000375645+130935_96413.02857.0Topological domainCytoplasmic
HgeneATP11Achr13:113344769chr11:17351673ENST00000375645+130987_100013.02857.0Topological domainExtracellular
HgeneATP11Achr13:113344769chr11:17351673ENST00000487903+1301024_102913.02878.0Topological domainCytoplasmic
HgeneATP11Achr13:113344769chr11:17351673ENST00000487903+1301051_106813.02878.0Topological domainExtracellular
HgeneATP11Achr13:113344769chr11:17351673ENST00000487903+1301094_113413.02878.0Topological domainCytoplasmic
HgeneATP11Achr13:113344769chr11:17351673ENST00000487903+130111_29613.02878.0Topological domainCytoplasmic
HgeneATP11Achr13:113344769chr11:17351673ENST00000487903+1301_6113.02878.0Topological domainCytoplasmic
HgeneATP11Achr13:113344769chr11:17351673ENST00000487903+130319_34913.02878.0Topological domainExtracellular
HgeneATP11Achr13:113344769chr11:17351673ENST00000487903+130373_88113.02878.0Topological domainCytoplasmic
HgeneATP11Achr13:113344769chr11:17351673ENST00000487903+13083_8813.02878.0Topological domainExtracellular
HgeneATP11Achr13:113344769chr11:17351673ENST00000487903+130903_91413.02878.0Topological domainExtracellular
HgeneATP11Achr13:113344769chr11:17351673ENST00000487903+130935_96413.02878.0Topological domainCytoplasmic
HgeneATP11Achr13:113344769chr11:17351673ENST00000487903+130987_100013.02878.0Topological domainExtracellular
HgeneATP11Achr13:113344769chr11:17351673ENST00000283558+1291001_102313.01135.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000283558+1291030_105013.01135.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000283558+1291069_109313.01135.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000283558+129297_31813.01135.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000283558+129350_37213.01135.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000283558+12962_8213.01135.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000283558+129882_90213.01135.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000283558+12989_11013.01135.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000283558+129915_93413.01135.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000283558+129965_98613.01135.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000375645+1301001_102313.02857.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000375645+1301030_105013.02857.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000375645+1301069_109313.02857.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000375645+130297_31813.02857.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000375645+130350_37213.02857.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000375645+13062_8213.02857.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000375645+130882_90213.02857.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000375645+13089_11013.02857.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000375645+130915_93413.02857.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000375645+130965_98613.02857.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000487903+1301001_102313.02878.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000487903+1301030_105013.02878.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000487903+1301069_109313.02878.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000487903+130297_31813.02878.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000487903+130350_37213.02878.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000487903+13062_8213.02878.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000487903+130882_90213.02878.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000487903+13089_11013.02878.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000487903+130915_93413.02878.0TransmembraneHelical
HgeneATP11Achr13:113344769chr11:17351673ENST00000487903+130965_98613.02878.0TransmembraneHelical
TgeneNUCB2chr13:113344769chr11:17351673ENST000003236881013254_265334.0421.0Calcium bindingNote=1
TgeneNUCB2chr13:113344769chr11:17351673ENST000003236881013306_317334.0421.0Calcium bindingNote=2
TgeneNUCB2chr13:113344769chr11:17351673ENST000005290101014254_265334.0421.0Calcium bindingNote=1
TgeneNUCB2chr13:113344769chr11:17351673ENST000005290101014306_317334.0421.0Calcium bindingNote=2
TgeneNUCB2chr13:113344769chr11:17351673ENST000003236881013282_293334.0421.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneNUCB2chr13:113344769chr11:17351673ENST000005290101014282_293334.0421.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneNUCB2chr13:113344769chr11:17351673ENST000003236881013171_223334.0421.0DNA bindingOntology_term=ECO:0000250
TgeneNUCB2chr13:113344769chr11:17351673ENST000005290101014171_223334.0421.0DNA bindingOntology_term=ECO:0000250
TgeneNUCB2chr13:113344769chr11:17351673ENST000003236881013241_276334.0421.0DomainEF-hand 1
TgeneNUCB2chr13:113344769chr11:17351673ENST000003236881013293_328334.0421.0DomainEF-hand 2
TgeneNUCB2chr13:113344769chr11:17351673ENST000005290101014241_276334.0421.0DomainEF-hand 1
TgeneNUCB2chr13:113344769chr11:17351673ENST000005290101014293_328334.0421.0DomainEF-hand 2
TgeneNUCB2chr13:113344769chr11:17351673ENST000003236881013304_334334.0421.0MotifGBA
TgeneNUCB2chr13:113344769chr11:17351673ENST000005290101014304_334334.0421.0MotifGBA
TgeneNUCB2chr13:113344769chr11:17351673ENST000003236881013213_420334.0421.0RegionBinds to necdin
TgeneNUCB2chr13:113344769chr11:17351673ENST000005290101014213_420334.0421.0RegionBinds to necdin


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ATP11A
NUCB2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ATP11A-NUCB2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ATP11A-NUCB2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource