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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ATP1A1-SORT1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ATP1A1-SORT1
FusionPDB ID: 7791
FusionGDB2.0 ID: 7791
HgeneTgene
Gene symbol

ATP1A1

SORT1

Gene ID

480

6272

Gene nameATPase Na+/K+ transporting subunit alpha 4sortilin 1
SynonymsATP1A1|ATP1AL2Gp95|LDLCQ6|NT3|NTR3
Cytomap

1q23.2

1p13.3|1p21.3-p13.1

Type of geneprotein-codingprotein-coding
Descriptionsodium/potassium-transporting ATPase subunit alpha-4ATPase, Na+/K+ transporting, alpha 4 polypeptideATPase, Na+/K+ transporting, alpha polypeptide-like 2Na(+)/K(+) ATPase alpha-4 subunitNa+/K+ ATPase 4Na+/K+ ATPase, alpha-D polypeptideNa,K-ATPase susortilin100 kDa NT receptorglycoprotein 95neurotensin receptor 3
Modification date2020031320200313
UniProtAcc

Q5TC04

.
Ensembl transtripts involved in fusion geneENST idsENST00000295598, ENST00000369496, 
ENST00000537345, ENST00000491156, 
ENST00000482236, ENST00000538502, 
ENST00000256637, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 18 X 7=20169 X 10 X 5=450
# samples 2312
** MAII scorelog2(23/2016*10)=-3.13178987255554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/450*10)=-1.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ATP1A1 [Title/Abstract] AND SORT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ATP1A1(116930113)-SORT1(109912211), # samples:2
Anticipated loss of major functional domain due to fusion event.ATP1A1-SORT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP1A1-SORT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP1A1-SORT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP1A1-SORT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATP1A1

GO:0030317

flagellated sperm motility

12112599

HgeneATP1A1

GO:0030641

regulation of cellular pH

12112599

TgeneSORT1

GO:0006895

Golgi to endosome transport

11331584

TgeneSORT1

GO:0006897

endocytosis

11331584|21092856

TgeneSORT1

GO:0007218

neuropeptide signaling pathway

9756851

TgeneSORT1

GO:0008333

endosome to lysosome transport

11331584

TgeneSORT1

GO:0008625

extrinsic apoptotic signaling pathway via death domain receptors

14985763

TgeneSORT1

GO:0016050

vesicle organization

15992544

TgeneSORT1

GO:0032509

endosome transport via multivesicular body sorting pathway

11331584

TgeneSORT1

GO:0048227

plasma membrane to endosome transport

11331584

TgeneSORT1

GO:0051005

negative regulation of lipoprotein lipase activity

10085125


check buttonFusion gene breakpoints across ATP1A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SORT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-85-7697-01AATP1A1chr1

116930113

+SORT1chr1

109912211

-
ChimerDB4LUSCTCGA-85-7697ATP1A1chr1

116930113

+SORT1chr1

109912211

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000295598ATP1A1chr1116930113+ENST00000256637SORT1chr1109912211-73026392372828863
ENST00000537345ATP1A1chr1116930113+ENST00000256637SORT1chr1109912211-74137503182939873
ENST00000369496ATP1A1chr1116930113+ENST00000256637SORT1chr1109912211-72225591632748861

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000295598ENST00000256637ATP1A1chr1116930113+SORT1chr1109912211-0.0003474840.9996525
ENST00000537345ENST00000256637ATP1A1chr1116930113+SORT1chr1109912211-0.0002728190.9997272
ENST00000369496ENST00000256637ATP1A1chr1116930113+SORT1chr1109912211-0.0004800590.99951994

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>7791_7791_1_ATP1A1-SORT1_ATP1A1_chr1_116930113_ENST00000295598_SORT1_chr1_109912211_ENST00000256637_length(amino acids)=863AA_BP=134
MSTATMGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPT
TPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNHVFDDLRGSVSLSWVGDSTGVILVLTTFHVPLVIMTFGQSKLYRSE
DYGKNFKDITDLINNTFIRTEFGMAIGPENSGKVVLTAEVSGGSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENG
LWVSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALELWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIH
VSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSV
LSEDNSIQTMITFDQGGRWTHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYIS
DDGGYSWTKMLEGPHYYTILDSGGIIVAIEHSSRPINVIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGFTESFLTSQWV
SYTIDFKDILERNCEEKDYTIWLAHSTDPEDYEDGCILGYKEQFLRLRKSSVCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPENDSKC
VEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDKCQGGVNPVREVKDLKKKCTSNFLSPEKQNSKSNSVPIILAIVGLMLVTVVAGVLIV

--------------------------------------------------------------

>7791_7791_2_ATP1A1-SORT1_ATP1A1_chr1_116930113_ENST00000369496_SORT1_chr1_109912211_ENST00000256637_length(amino acids)=861AA_BP=132
MPKDTLLVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTP
EWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNHVFDDLRGSVSLSWVGDSTGVILVLTTFHVPLVIMTFGQSKLYRSEDY
GKNFKDITDLINNTFIRTEFGMAIGPENSGKVVLTAEVSGGSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLW
VSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALELWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVS
TDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSVLS
EDNSIQTMITFDQGGRWTHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDD
GGYSWTKMLEGPHYYTILDSGGIIVAIEHSSRPINVIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGFTESFLTSQWVSY
TIDFKDILERNCEEKDYTIWLAHSTDPEDYEDGCILGYKEQFLRLRKSSVCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPENDSKCVE
QPELKGHDLEFCLYGREEHLTTNGYRKIPGDKCQGGVNPVREVKDLKKKCTSNFLSPEKQNSKSNSVPIILAIVGLMLVTVVAGVLIVKK

--------------------------------------------------------------

>7791_7791_3_ATP1A1-SORT1_ATP1A1_chr1_116930113_ENST00000537345_SORT1_chr1_109912211_ENST00000256637_length(amino acids)=873AA_BP=144
MGGLVPERVCLHCPKMAFKVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARD
GPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNHVFDDLRGSVSLSWVGDSTGVILVLTTFHVPLVIMT
FGQSKLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSGKVVLTAEVSGGSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSD
YLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALELWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVM
ADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVT
SLRGVYITSVLSEDNSIQTMITFDQGGRWTHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAI
SVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHSSRPINVIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGF
TESFLTSQWVSYTIDFKDILERNCEEKDYTIWLAHSTDPEDYEDGCILGYKEQFLRLRKSSVCQNGRDYVVTKQPSICLCSLEDFLCDFG
YYRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDKCQGGVNPVREVKDLKKKCTSNFLSPEKQNSKSNSVPIILAIVGLML

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:116930113/chr1:109912211)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP1A1

Q5TC04

.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+42382_84129.01024.0RegionPhosphoinositide-3 kinase binding
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+42382_8498.0993.0RegionPhosphoinositide-3 kinase binding
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+42382_84129.01024.0RegionPhosphoinositide-3 kinase binding
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423109_131129.01024.0Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+4236_87129.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+4236_8798.0993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423109_131129.01024.0Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+4236_87129.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+42388_108129.01024.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+42388_108129.01024.0TransmembraneHelical
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637020787_792102.0832.0MotifEndocytosis signal
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502020787_7920695.0MotifEndocytosis signal
TgeneSORT1chr1:116930113chr1:109912211ENST0000053850202050_610695.0RegionNote=Intrachain binding of the propeptide and the extracellular domain
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637020145_156102.0832.0RepeatNote=BNR 1
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637020198_209102.0832.0RepeatNote=BNR 2
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637020240_251102.0832.0RepeatNote=BNR 3
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637020287_298102.0832.0RepeatNote=BNR 4
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637020328_339102.0832.0RepeatNote=BNR 5
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637020377_388102.0832.0RepeatNote=BNR 6
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637020428_439102.0832.0RepeatNote=BNR 7
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637020506_517102.0832.0RepeatNote=BNR 8
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637020548_559102.0832.0RepeatNote=BNR 9
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502020145_1560695.0RepeatNote=BNR 1
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502020198_2090695.0RepeatNote=BNR 2
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502020240_2510695.0RepeatNote=BNR 3
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502020287_2980695.0RepeatNote=BNR 4
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502020328_3390695.0RepeatNote=BNR 5
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502020377_3880695.0RepeatNote=BNR 6
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502020428_4390695.0RepeatNote=BNR 7
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502020506_5170695.0RepeatNote=BNR 8
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502020548_5590695.0RepeatNote=BNR 9
TgeneSORT1chr1:116930113chr1:109912211ENST0000053850202078_7550695.0Topological domainExtracellular
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637020756_778102.0832.0TransmembraneHelical
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502020756_7780695.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+4231007_1023129.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423153_288129.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423309_320129.01024.0Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423339_772129.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423793_802129.01024.0Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423824_843129.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423867_918129.01024.0Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423939_951129.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423971_985129.01024.0Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+4231007_102398.0993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423109_13198.0993.0Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423153_28898.0993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423309_32098.0993.0Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423339_77298.0993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423793_80298.0993.0Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423824_84398.0993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423867_91898.0993.0Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423939_95198.0993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423971_98598.0993.0Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+4231007_1023129.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423153_288129.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423309_320129.01024.0Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423339_772129.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423793_802129.01024.0Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423824_843129.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423867_918129.01024.0Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423939_951129.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423971_985129.01024.0Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423132_152129.01024.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423289_308129.01024.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423321_338129.01024.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423773_792129.01024.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423803_823129.01024.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423844_866129.01024.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423919_938129.01024.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423952_970129.01024.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423986_1006129.01024.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423132_15298.0993.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423289_30898.0993.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423321_33898.0993.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423773_79298.0993.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423803_82398.0993.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423844_86698.0993.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+42388_10898.0993.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423919_93898.0993.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423952_97098.0993.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423986_100698.0993.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423132_152129.01024.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423289_308129.01024.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423321_338129.01024.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423773_792129.01024.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423803_823129.01024.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423844_866129.01024.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423919_938129.01024.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423952_970129.01024.0TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423986_1006129.01024.0TransmembraneHelical
TgeneSORT1chr1:116930113chr1:109912211ENST0000025663702050_61102.0832.0RegionNote=Intrachain binding of the propeptide and the extracellular domain
TgeneSORT1chr1:116930113chr1:109912211ENST0000025663702078_755102.0832.0Topological domainExtracellular


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1661_ATP1A1_116930113_SORT1_109912211_ranked_0.pdbATP1A1116930113116930113ENST00000256637SORT1chr1109912211-
MGGLVPERVCLHCPKMAFKVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARD
GPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNHVFDDLRGSVSLSWVGDSTGVILVLTTFHVPLVIMT
FGQSKLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSGKVVLTAEVSGGSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSD
YLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALELWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVM
ADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVT
SLRGVYITSVLSEDNSIQTMITFDQGGRWTHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAI
SVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHSSRPINVIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGF
TESFLTSQWVSYTIDFKDILERNCEEKDYTIWLAHSTDPEDYEDGCILGYKEQFLRLRKSSVCQNGRDYVVTKQPSICLCSLEDFLCDFG
YYRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDKCQGGVNPVREVKDLKKKCTSNFLSPEKQNSKSNSVPIILAIVGLML
873


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ATP1A1_pLDDT.png
all structure
all structure
SORT1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ATP1A1
SORT1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ATP1A1-SORT1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ATP1A1-SORT1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource