UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:ATP1B1-DCAF6

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ATP1B1-DCAF6
FusionPDB ID: 7801
FusionGDB2.0 ID: 7801
HgeneTgene
Gene symbol

ATP1B1

DCAF6

Gene ID

481

55827

Gene nameATPase Na+/K+ transporting subunit beta 1DDB1 and CUL4 associated factor 6
SynonymsATP1B1200006M05Rik|ARCAP|IQWD1|MSTP055|NRIP|PC326
Cytomap

1q24.2

1q24.2

Type of geneprotein-codingprotein-coding
Descriptionsodium/potassium-transporting ATPase subunit beta-1ATPase, Na+/K+ transporting, beta 1 polypeptideBeta 1-subunit of Na(+),K(+)-ATPaseNa, K-ATPase beta-1 polypeptideadenosinetriphosphatasesodium pump subunit beta-1sodium-potassium ATPase subunit betaDDB1- and CUL4-associated factor 6IQ motif and WD repeat-containing protein 1IQ motif and WD repeats 1androgen receptor complex-associated proteinnuclear receptor interaction protein
Modification date2020031320200313
UniProtAcc

P05026

Q58WW2

Ensembl transtripts involved in fusion geneENST idsENST00000367813, ENST00000367815, 
ENST00000367816, ENST00000499679, 
ENST00000470919, ENST00000312263, 
ENST00000367840, ENST00000367843, 
ENST00000432587, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 12 X 7=92410 X 9 X 8=720
# samples 1610
** MAII scorelog2(16/924*10)=-2.5298209465287
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/720*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ATP1B1 [Title/Abstract] AND DCAF6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ATP1B1(169080736)-DCAF6(167921038), # samples:1
Anticipated loss of major functional domain due to fusion event.ATP1B1-DCAF6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP1B1-DCAF6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP1B1-DCAF6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP1B1-DCAF6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATP1B1

GO:0006883

cellular sodium ion homeostasis

10636900|19542013

HgeneATP1B1

GO:0030007

cellular potassium ion homeostasis

10636900|19542013

HgeneATP1B1

GO:0032781

positive regulation of ATPase activity

10636900

HgeneATP1B1

GO:0036376

sodium ion export across plasma membrane

10636900|19542013

HgeneATP1B1

GO:0046034

ATP metabolic process

23954377

HgeneATP1B1

GO:0050821

protein stabilization

10636900

HgeneATP1B1

GO:0072659

protein localization to plasma membrane

18522992

HgeneATP1B1

GO:0086009

membrane repolarization

19542013

HgeneATP1B1

GO:1901018

positive regulation of potassium ion transmembrane transporter activity

10636900

HgeneATP1B1

GO:1903278

positive regulation of sodium ion export across plasma membrane

10636900

HgeneATP1B1

GO:1903288

positive regulation of potassium ion import

10636900

HgeneATP1B1

GO:1990573

potassium ion import across plasma membrane

10636900|19542013


check buttonFusion gene breakpoints across ATP1B1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DCAF6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-QQ-A8VH-01AATP1B1chr1

169080736

+DCAF6chr1

167921038

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367816ATP1B1chr1169080736+ENST00000367843DCAF6chr1167921038+37097555293300923
ENST00000367816ATP1B1chr1169080736+ENST00000432587DCAF6chr1167921038+36177555293420963
ENST00000367816ATP1B1chr1169080736+ENST00000312263DCAF6chr1167921038+36407555293240903
ENST00000367816ATP1B1chr1169080736+ENST00000367840DCAF6chr1167921038+39137555293513994
ENST00000367815ATP1B1chr1169080736+ENST00000367843DCAF6chr1167921038+36877335073278923
ENST00000367815ATP1B1chr1169080736+ENST00000432587DCAF6chr1167921038+35957335073398963
ENST00000367815ATP1B1chr1169080736+ENST00000312263DCAF6chr1167921038+36187335073218903
ENST00000367815ATP1B1chr1169080736+ENST00000367840DCAF6chr1167921038+38917335073491994
ENST00000499679ATP1B1chr1169080736+ENST00000367843DCAF6chr1167921038+32462922012837878
ENST00000499679ATP1B1chr1169080736+ENST00000432587DCAF6chr1167921038+31542922012957918
ENST00000499679ATP1B1chr1169080736+ENST00000312263DCAF6chr1167921038+31772922012777858
ENST00000499679ATP1B1chr1169080736+ENST00000367840DCAF6chr1167921038+34502922013050949
ENST00000367813ATP1B1chr1169080736+ENST00000367843DCAF6chr1167921038+3189235242780918
ENST00000367813ATP1B1chr1169080736+ENST00000432587DCAF6chr1167921038+3097235242900958
ENST00000367813ATP1B1chr1169080736+ENST00000312263DCAF6chr1167921038+3120235242720898
ENST00000367813ATP1B1chr1169080736+ENST00000367840DCAF6chr1167921038+3393235242993989

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367816ENST00000367843ATP1B1chr1169080736+DCAF6chr1167921038+0.0010427880.99895716
ENST00000367816ENST00000432587ATP1B1chr1169080736+DCAF6chr1167921038+0.0022726630.99772733
ENST00000367816ENST00000312263ATP1B1chr1169080736+DCAF6chr1167921038+0.0009818360.9990182
ENST00000367816ENST00000367840ATP1B1chr1169080736+DCAF6chr1167921038+0.0011010670.99889886
ENST00000367815ENST00000367843ATP1B1chr1169080736+DCAF6chr1167921038+0.0008470390.999153
ENST00000367815ENST00000432587ATP1B1chr1169080736+DCAF6chr1167921038+0.0018022470.99819773
ENST00000367815ENST00000312263ATP1B1chr1169080736+DCAF6chr1167921038+0.000797350.99920267
ENST00000367815ENST00000367840ATP1B1chr1169080736+DCAF6chr1167921038+0.0008850330.99911493
ENST00000499679ENST00000367843ATP1B1chr1169080736+DCAF6chr1167921038+0.0005481180.99945194
ENST00000499679ENST00000432587ATP1B1chr1169080736+DCAF6chr1167921038+0.0008709820.999129
ENST00000499679ENST00000312263ATP1B1chr1169080736+DCAF6chr1167921038+0.0005829950.99941707
ENST00000499679ENST00000367840ATP1B1chr1169080736+DCAF6chr1167921038+0.0004722570.9995278
ENST00000367813ENST00000367843ATP1B1chr1169080736+DCAF6chr1167921038+0.0003819230.99961805
ENST00000367813ENST00000432587ATP1B1chr1169080736+DCAF6chr1167921038+0.0003462180.9996538
ENST00000367813ENST00000312263ATP1B1chr1169080736+DCAF6chr1167921038+0.0004829190.9995171
ENST00000367813ENST00000367840ATP1B1chr1169080736+DCAF6chr1167921038+0.0003262320.9996737

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>7801_7801_1_ATP1B1-DCAF6_ATP1B1_chr1_169080736_ENST00000367813_DCAF6_chr1_167921038_ENST00000312263_length(amino acids)=898AA_BP=70
MLTMGKRKCSPASQSLFLFQFQKMELKFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGRREFIQRLKLEATLNVHDG
CVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYG
TTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNY
AGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPR
ARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPS
TSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSDNNNEKLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWSSI
ASSSRGIGSHCKSEGQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAENPVENHINITQSDKFTAKPLDSNSGERNDLNLDRS
CGVPEESASSEKAKEPETSDQTSTESATNENNTNPEPQFQTEATGPSAHEETSTRDSALQDTDDSDDDPVLIPGARYRAGPGDRRSAVAR
IQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPF

--------------------------------------------------------------

>7801_7801_2_ATP1B1-DCAF6_ATP1B1_chr1_169080736_ENST00000367813_DCAF6_chr1_167921038_ENST00000367840_length(amino acids)=989AA_BP=70
MLTMGKRKCSPASQSLFLFQFQKMELKFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGRREFIQRLKLEATLNVHDG
CVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYG
TTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNY
AGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPR
ARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPS
TSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSEFLRGPEIALLRKRLQQLRLKKAEQQRQQELAAHTQQQPSTSD
QSSHEGSSQDPHASDSPSSVVNKQLGSMSLDEQQDNNNEKLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWSSIASSSRGIGSHCKS
EGQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAENPVENHINITQSDKFTAKPLDSNSGERNDLNLDRSCGVPEESASSEKA
KEPETSDQTSTESATNENNTNPEPQFQTEATGPSAHEETSTRDSALQDTDDSDDDPVLIPGARYRAGPGDRFNIRGTTIGDRIMRRSAVA
RIQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHP

--------------------------------------------------------------

>7801_7801_3_ATP1B1-DCAF6_ATP1B1_chr1_169080736_ENST00000367813_DCAF6_chr1_167921038_ENST00000367843_length(amino acids)=918AA_BP=70
MLTMGKRKCSPASQSLFLFQFQKMELKFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGRREFIQRLKLEATLNVHDG
CVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYG
TTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNY
AGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPR
ARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPS
TSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSDSPSSVVNKQLGSMSLDEQQDNNNEKLSPKPGTGEPVLSLHYS
TEGTTTSTIKLNFTDEWSSIASSSRGIGSHCKSEGQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAENPVENHINITQSDKF
TAKPLDSNSGERNDLNLDRSCGVPEESASSEKAKEPETSDQTSTESATNENNTNPEPQFQTEATGPSAHEETSTRDSALQDTDDSDDDPV
LIPGARYRAGPGDRRSAVARIQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWDRHTAE
HLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSPLEESRIFNRKLADEVITRNELMLEETRNTITVPASFMLRMLASLNHIRADRL

--------------------------------------------------------------

>7801_7801_4_ATP1B1-DCAF6_ATP1B1_chr1_169080736_ENST00000367813_DCAF6_chr1_167921038_ENST00000432587_length(amino acids)=958AA_BP=70
MLTMGKRKCSPASQSLFLFQFQKMELKFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGRREFIQRLKLEATLNVHDG
CVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRI
KTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSE
DGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWF
EEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSE
QRQSVEASGHHTHHQSEFLRGPEIALLRKRLQQLRLKKAEQQRQQELAAHTQQQPSTSDQSSHEGSSQDPHASDSPSSVVNKQLGSMSLD
EQQDNNNEKLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWSSIASSSRGIGSHCKSEGQEESFVPQSSVQPPEGDSETKAPEESSED
VTKYQEGVSAENPVENHINITQSDKFTAKPLDSNSGERNDLNLDRSCGVPEESASSEKAKEPETSDQTSTESATNENNTNPEPQFQTEAT
GPSAHEETSTRDSALQDTDDSDDDPVLIPGARYRAGPGDRFNIRGTTIGDRIMRRSAVARIQEFFRRRKERKEMEELDTLNIRRPLVKMV
YKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSPLEESRIFNRKLA

--------------------------------------------------------------

>7801_7801_5_ATP1B1-DCAF6_ATP1B1_chr1_169080736_ENST00000367815_DCAF6_chr1_167921038_ENST00000312263_length(amino acids)=903AA_BP=75
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGRREFIQRLKLEATL
NVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQF
TCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTR
ATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWS
DTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQ
FLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSDNNNEKLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTD
EWSSIASSSRGIGSHCKSEGQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAENPVENHINITQSDKFTAKPLDSNSGERNDL
NLDRSCGVPEESASSEKAKEPETSDQTSTESATNENNTNPEPQFQTEATGPSAHEETSTRDSALQDTDDSDDDPVLIPGARYRAGPGDRR
SAVARIQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCL
QPHPFDPILASSGIDYDIKIWSPLEESRIFNRKLADEVITRNELMLEETRNTITVPASFMLRMLASLNHIRADRLEGDRSEGSGQENENE

--------------------------------------------------------------

>7801_7801_6_ATP1B1-DCAF6_ATP1B1_chr1_169080736_ENST00000367815_DCAF6_chr1_167921038_ENST00000367840_length(amino acids)=994AA_BP=75
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGRREFIQRLKLEATL
NVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQF
TCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTR
ATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWS
DTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQ
FLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSEFLRGPEIALLRKRLQQLRLKKAEQQRQQELAAHTQQQ
PSTSDQSSHEGSSQDPHASDSPSSVVNKQLGSMSLDEQQDNNNEKLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWSSIASSSRGIG
SHCKSEGQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAENPVENHINITQSDKFTAKPLDSNSGERNDLNLDRSCGVPEESA
SSEKAKEPETSDQTSTESATNENNTNPEPQFQTEATGPSAHEETSTRDSALQDTDDSDDDPVLIPGARYRAGPGDRFNIRGTTIGDRIMR
RSAVARIQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNC
LQPHPFDPILASSGIDYDIKIWSPLEESRIFNRKLADEVITRNELMLEETRNTITVPASFMLRMLASLNHIRADRLEGDRSEGSGQENEN

--------------------------------------------------------------

>7801_7801_7_ATP1B1-DCAF6_ATP1B1_chr1_169080736_ENST00000367815_DCAF6_chr1_167921038_ENST00000367843_length(amino acids)=923AA_BP=75
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGRREFIQRLKLEATL
NVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQF
TCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTR
ATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWS
DTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQ
FLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSDSPSSVVNKQLGSMSLDEQQDNNNEKLSPKPGTGEPVL
SLHYSTEGTTTSTIKLNFTDEWSSIASSSRGIGSHCKSEGQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAENPVENHINIT
QSDKFTAKPLDSNSGERNDLNLDRSCGVPEESASSEKAKEPETSDQTSTESATNENNTNPEPQFQTEATGPSAHEETSTRDSALQDTDDS
DDDPVLIPGARYRAGPGDRRSAVARIQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWD
RHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSPLEESRIFNRKLADEVITRNELMLEETRNTITVPASFMLRMLASLNHI

--------------------------------------------------------------

>7801_7801_8_ATP1B1-DCAF6_ATP1B1_chr1_169080736_ENST00000367815_DCAF6_chr1_167921038_ENST00000432587_length(amino acids)=963AA_BP=75
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGRREFIQRLKLEATL
NVHDGCVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRW
FDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTS
LCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDM
LSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLS
SPDSEQRQSVEASGHHTHHQSEFLRGPEIALLRKRLQQLRLKKAEQQRQQELAAHTQQQPSTSDQSSHEGSSQDPHASDSPSSVVNKQLG
SMSLDEQQDNNNEKLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWSSIASSSRGIGSHCKSEGQEESFVPQSSVQPPEGDSETKAPE
ESSEDVTKYQEGVSAENPVENHINITQSDKFTAKPLDSNSGERNDLNLDRSCGVPEESASSEKAKEPETSDQTSTESATNENNTNPEPQF
QTEATGPSAHEETSTRDSALQDTDDSDDDPVLIPGARYRAGPGDRFNIRGTTIGDRIMRRSAVARIQEFFRRRKERKEMEELDTLNIRRP
LVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSPLEESRIF

--------------------------------------------------------------

>7801_7801_9_ATP1B1-DCAF6_ATP1B1_chr1_169080736_ENST00000367816_DCAF6_chr1_167921038_ENST00000312263_length(amino acids)=903AA_BP=75
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGRREFIQRLKLEATL
NVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQF
TCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTR
ATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWS
DTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQ
FLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSDNNNEKLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTD
EWSSIASSSRGIGSHCKSEGQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAENPVENHINITQSDKFTAKPLDSNSGERNDL
NLDRSCGVPEESASSEKAKEPETSDQTSTESATNENNTNPEPQFQTEATGPSAHEETSTRDSALQDTDDSDDDPVLIPGARYRAGPGDRR
SAVARIQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCL
QPHPFDPILASSGIDYDIKIWSPLEESRIFNRKLADEVITRNELMLEETRNTITVPASFMLRMLASLNHIRADRLEGDRSEGSGQENENE

--------------------------------------------------------------

>7801_7801_10_ATP1B1-DCAF6_ATP1B1_chr1_169080736_ENST00000367816_DCAF6_chr1_167921038_ENST00000367840_length(amino acids)=994AA_BP=75
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGRREFIQRLKLEATL
NVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQF
TCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTR
ATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWS
DTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQ
FLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSEFLRGPEIALLRKRLQQLRLKKAEQQRQQELAAHTQQQ
PSTSDQSSHEGSSQDPHASDSPSSVVNKQLGSMSLDEQQDNNNEKLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWSSIASSSRGIG
SHCKSEGQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAENPVENHINITQSDKFTAKPLDSNSGERNDLNLDRSCGVPEESA
SSEKAKEPETSDQTSTESATNENNTNPEPQFQTEATGPSAHEETSTRDSALQDTDDSDDDPVLIPGARYRAGPGDRFNIRGTTIGDRIMR
RSAVARIQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNC
LQPHPFDPILASSGIDYDIKIWSPLEESRIFNRKLADEVITRNELMLEETRNTITVPASFMLRMLASLNHIRADRLEGDRSEGSGQENEN

--------------------------------------------------------------

>7801_7801_11_ATP1B1-DCAF6_ATP1B1_chr1_169080736_ENST00000367816_DCAF6_chr1_167921038_ENST00000367843_length(amino acids)=923AA_BP=75
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGRREFIQRLKLEATL
NVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQF
TCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTR
ATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWS
DTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQ
FLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSDSPSSVVNKQLGSMSLDEQQDNNNEKLSPKPGTGEPVL
SLHYSTEGTTTSTIKLNFTDEWSSIASSSRGIGSHCKSEGQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAENPVENHINIT
QSDKFTAKPLDSNSGERNDLNLDRSCGVPEESASSEKAKEPETSDQTSTESATNENNTNPEPQFQTEATGPSAHEETSTRDSALQDTDDS
DDDPVLIPGARYRAGPGDRRSAVARIQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWD
RHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSPLEESRIFNRKLADEVITRNELMLEETRNTITVPASFMLRMLASLNHI

--------------------------------------------------------------

>7801_7801_12_ATP1B1-DCAF6_ATP1B1_chr1_169080736_ENST00000367816_DCAF6_chr1_167921038_ENST00000432587_length(amino acids)=963AA_BP=75
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGRREFIQRLKLEATL
NVHDGCVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRW
FDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTS
LCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDM
LSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLS
SPDSEQRQSVEASGHHTHHQSEFLRGPEIALLRKRLQQLRLKKAEQQRQQELAAHTQQQPSTSDQSSHEGSSQDPHASDSPSSVVNKQLG
SMSLDEQQDNNNEKLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWSSIASSSRGIGSHCKSEGQEESFVPQSSVQPPEGDSETKAPE
ESSEDVTKYQEGVSAENPVENHINITQSDKFTAKPLDSNSGERNDLNLDRSCGVPEESASSEKAKEPETSDQTSTESATNENNTNPEPQF
QTEATGPSAHEETSTRDSALQDTDDSDDDPVLIPGARYRAGPGDRFNIRGTTIGDRIMRRSAVARIQEFFRRRKERKEMEELDTLNIRRP
LVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSPLEESRIF

--------------------------------------------------------------

>7801_7801_13_ATP1B1-DCAF6_ATP1B1_chr1_169080736_ENST00000499679_DCAF6_chr1_167921038_ENST00000312263_length(amino acids)=858AA_BP=30
MAGIFIGTIQVMLLTISEFKPTYQDRVAPPGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIRSG
HRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDC
KDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSY
SSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQS
NRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASG
HHTHHQSDNNNEKLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWSSIASSSRGIGSHCKSEGQEESFVPQSSVQPPEGDSETKAPEE
SSEDVTKYQEGVSAENPVENHINITQSDKFTAKPLDSNSGERNDLNLDRSCGVPEESASSEKAKEPETSDQTSTESATNENNTNPEPQFQ
TEATGPSAHEETSTRDSALQDTDDSDDDPVLIPGARYRAGPGDRRSAVARIQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTM
IKEANFWGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSPLEESRIFNRKLADEVITRNELM

--------------------------------------------------------------

>7801_7801_14_ATP1B1-DCAF6_ATP1B1_chr1_169080736_ENST00000499679_DCAF6_chr1_167921038_ENST00000367840_length(amino acids)=949AA_BP=30
MAGIFIGTIQVMLLTISEFKPTYQDRVAPPGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIRSG
HRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDC
KDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSY
SSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQS
NRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASG
HHTHHQSEFLRGPEIALLRKRLQQLRLKKAEQQRQQELAAHTQQQPSTSDQSSHEGSSQDPHASDSPSSVVNKQLGSMSLDEQQDNNNEK
LSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWSSIASSSRGIGSHCKSEGQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVS
AENPVENHINITQSDKFTAKPLDSNSGERNDLNLDRSCGVPEESASSEKAKEPETSDQTSTESATNENNTNPEPQFQTEATGPSAHEETS
TRDSALQDTDDSDDDPVLIPGARYRAGPGDRFNIRGTTIGDRIMRRSAVARIQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRT
MIKEANFWGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSPLEESRIFNRKLADEVITRNEL

--------------------------------------------------------------

>7801_7801_15_ATP1B1-DCAF6_ATP1B1_chr1_169080736_ENST00000499679_DCAF6_chr1_167921038_ENST00000367843_length(amino acids)=878AA_BP=30
MAGIFIGTIQVMLLTISEFKPTYQDRVAPPGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIRSG
HRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDC
KDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSY
SSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQS
NRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASG
HHTHHQSDSPSSVVNKQLGSMSLDEQQDNNNEKLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWSSIASSSRGIGSHCKSEGQEESF
VPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAENPVENHINITQSDKFTAKPLDSNSGERNDLNLDRSCGVPEESASSEKAKEPETSD
QTSTESATNENNTNPEPQFQTEATGPSAHEETSTRDSALQDTDDSDDDPVLIPGARYRAGPGDRRSAVARIQEFFRRRKERKEMEELDTL
NIRRPLVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSPLE

--------------------------------------------------------------

>7801_7801_16_ATP1B1-DCAF6_ATP1B1_chr1_169080736_ENST00000499679_DCAF6_chr1_167921038_ENST00000432587_length(amino acids)=918AA_BP=30
MAGIFIGTIQVMLLTISEFKPTYQDRVAPPGRREFIQRLKLEATLNVHDGCVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYT
NVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGCSD
SSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREELR
QPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLE
VSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSEFLRGPEIALLRKRLQQLRLKKAE
QQRQQELAAHTQQQPSTSDQSSHEGSSQDPHASDSPSSVVNKQLGSMSLDEQQDNNNEKLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFT
DEWSSIASSSRGIGSHCKSEGQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAENPVENHINITQSDKFTAKPLDSNSGERND
LNLDRSCGVPEESASSEKAKEPETSDQTSTESATNENNTNPEPQFQTEATGPSAHEETSTRDSALQDTDDSDDDPVLIPGARYRAGPGDR
FNIRGTTIGDRIMRRSAVARIQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWDRHTAE
HLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSPLEESRIFNRKLADEVITRNELMLEETRNTITVPASFMLRMLASLNHIRADRL

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:169080736/chr1:167921038)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP1B1

P05026

DCAF6

Q58WW2

FUNCTION: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. {ECO:0000269|PubMed:19694409}.; FUNCTION: Involved in cell adhesion and establishing epithelial cell polarity. {ECO:0000269|PubMed:19694409}.FUNCTION: Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:15784617, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP1B1chr1:169080736chr1:167921038ENST00000367815+261_3475.33333333333333304.0Topological domainCytoplasmic
HgeneATP1B1chr1:169080736chr1:167921038ENST00000367816+371_3475.33333333333333304.0Topological domainCytoplasmic
HgeneATP1B1chr1:169080736chr1:167921038ENST00000367815+2635_6275.33333333333333304.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneATP1B1chr1:169080736chr1:167921038ENST00000367816+3735_6275.33333333333333304.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneDCAF6chr1:169080736chr1:167921038ENST00000312263019676_70532.333333333333336861.0DomainIQ
TgeneDCAF6chr1:169080736chr1:167921038ENST00000367840022676_70532.333333333333336952.0DomainIQ
TgeneDCAF6chr1:169080736chr1:167921038ENST00000367843020676_70532.333333333333336881.0DomainIQ
TgeneDCAF6chr1:169080736chr1:167921038ENST00000432587021676_70532.333333333333336921.0DomainIQ
TgeneDCAF6chr1:169080736chr1:167921038ENST00000312263019139_17932.333333333333336861.0RepeatNote=WD 3
TgeneDCAF6chr1:169080736chr1:167921038ENST00000312263019189_22932.333333333333336861.0RepeatNote=WD 4
TgeneDCAF6chr1:169080736chr1:167921038ENST00000312263019251_29032.333333333333336861.0RepeatNote=WD 5
TgeneDCAF6chr1:169080736chr1:167921038ENST0000031226301949_8832.333333333333336861.0RepeatNote=WD 1
TgeneDCAF6chr1:169080736chr1:167921038ENST00000312263019718_75632.333333333333336861.0RepeatNote=WD 6
TgeneDCAF6chr1:169080736chr1:167921038ENST00000312263019759_79832.333333333333336861.0RepeatNote=WD 7
TgeneDCAF6chr1:169080736chr1:167921038ENST0000031226301992_13332.333333333333336861.0RepeatNote=WD 2
TgeneDCAF6chr1:169080736chr1:167921038ENST00000367840022139_17932.333333333333336952.0RepeatNote=WD 3
TgeneDCAF6chr1:169080736chr1:167921038ENST00000367840022189_22932.333333333333336952.0RepeatNote=WD 4
TgeneDCAF6chr1:169080736chr1:167921038ENST00000367840022251_29032.333333333333336952.0RepeatNote=WD 5
TgeneDCAF6chr1:169080736chr1:167921038ENST0000036784002249_8832.333333333333336952.0RepeatNote=WD 1
TgeneDCAF6chr1:169080736chr1:167921038ENST00000367840022718_75632.333333333333336952.0RepeatNote=WD 6
TgeneDCAF6chr1:169080736chr1:167921038ENST00000367840022759_79832.333333333333336952.0RepeatNote=WD 7
TgeneDCAF6chr1:169080736chr1:167921038ENST0000036784002292_13332.333333333333336952.0RepeatNote=WD 2
TgeneDCAF6chr1:169080736chr1:167921038ENST00000367843020139_17932.333333333333336881.0RepeatNote=WD 3
TgeneDCAF6chr1:169080736chr1:167921038ENST00000367843020189_22932.333333333333336881.0RepeatNote=WD 4
TgeneDCAF6chr1:169080736chr1:167921038ENST00000367843020251_29032.333333333333336881.0RepeatNote=WD 5
TgeneDCAF6chr1:169080736chr1:167921038ENST0000036784302049_8832.333333333333336881.0RepeatNote=WD 1
TgeneDCAF6chr1:169080736chr1:167921038ENST00000367843020718_75632.333333333333336881.0RepeatNote=WD 6
TgeneDCAF6chr1:169080736chr1:167921038ENST00000367843020759_79832.333333333333336881.0RepeatNote=WD 7
TgeneDCAF6chr1:169080736chr1:167921038ENST0000036784302092_13332.333333333333336881.0RepeatNote=WD 2
TgeneDCAF6chr1:169080736chr1:167921038ENST00000432587021139_17932.333333333333336921.0RepeatNote=WD 3
TgeneDCAF6chr1:169080736chr1:167921038ENST00000432587021189_22932.333333333333336921.0RepeatNote=WD 4
TgeneDCAF6chr1:169080736chr1:167921038ENST00000432587021251_29032.333333333333336921.0RepeatNote=WD 5
TgeneDCAF6chr1:169080736chr1:167921038ENST0000043258702149_8832.333333333333336921.0RepeatNote=WD 1
TgeneDCAF6chr1:169080736chr1:167921038ENST00000432587021718_75632.333333333333336921.0RepeatNote=WD 6
TgeneDCAF6chr1:169080736chr1:167921038ENST00000432587021759_79832.333333333333336921.0RepeatNote=WD 7
TgeneDCAF6chr1:169080736chr1:167921038ENST0000043258702192_13332.333333333333336921.0RepeatNote=WD 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP1B1chr1:169080736chr1:167921038ENST00000367815+26191_30375.33333333333333304.0RegionNote=immunoglobulin-like
HgeneATP1B1chr1:169080736chr1:167921038ENST00000367816+37191_30375.33333333333333304.0RegionNote=immunoglobulin-like
HgeneATP1B1chr1:169080736chr1:167921038ENST00000367815+2663_30375.33333333333333304.0Topological domainExtracellular
HgeneATP1B1chr1:169080736chr1:167921038ENST00000367816+3763_30375.33333333333333304.0Topological domainExtracellular


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ATP1B1
DCAF6


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to ATP1B1-DCAF6


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to ATP1B1-DCAF6


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource