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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ATP2A2-ATP2A3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ATP2A2-ATP2A3
FusionPDB ID: 7827
FusionGDB2.0 ID: 7827
HgeneTgene
Gene symbol

ATP2A2

ATP2A3

Gene ID

488

489

Gene nameATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
SynonymsATP2B|DAR|DD|SERCA2SERCA3
Cytomap

12q24.11

17p13.2

Type of geneprotein-codingprotein-coding
Descriptionsarcoplasmic/endoplasmic reticulum calcium ATPase 2ATPase Ca++ transporting cardiac muscle slow twitch 2ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2SR Ca(2+)-ATPase 2calcium pump 2calcium-transporting ATPase sarcoplasmic reticulum type, slowsarcoplasmic/endoplasmic reticulum calcium ATPase 3ATPase, Ca(2+)-transporting, ubiquitousATPase, Ca++ transporting, ubiquitousSR Ca(2+)-ATPase 3adenosine triphosphatase, calciumcalcium pump 3calcium-translocating P-type ATPasesarco/endoplasmic ret
Modification date2020031320200313
UniProtAcc

P16615

Q93084

Ensembl transtripts involved in fusion geneENST idsENST00000308664, ENST00000395494, 
ENST00000539276, ENST00000550248, 
ENST00000552636, 		ENST00000352011, 
ENST00000359983, ENST00000397039, 
ENST00000397043, ENST00000309890, 
ENST00000397035, ENST00000397041, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 22 X 11=41145 X 3 X 5=75
# samples 275
** MAII scorelog2(27/4114*10)=-3.9295104814741
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ATP2A2 [Title/Abstract] AND ATP2A3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ATP2A2(110777208)-ATP2A3(3844948), # samples:1
Anticipated loss of major functional domain due to fusion event.ATP2A2-ATP2A3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP2A2-ATP2A3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP2A2-ATP2A3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP2A2-ATP2A3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATP2A2

GO:0032469

endoplasmic reticulum calcium ion homeostasis

16402920

HgeneATP2A2

GO:0032470

positive regulation of endoplasmic reticulum calcium ion concentration

16402920

HgeneATP2A2

GO:0070588

calcium ion transmembrane transport

16402920

HgeneATP2A2

GO:1903515

calcium ion transport from cytosol to endoplasmic reticulum

16402920

TgeneATP2A3

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

16725111

TgeneATP2A3

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

16725111

TgeneATP2A3

GO:0070588

calcium ion transmembrane transport

9843705|11956212

TgeneATP2A3

GO:1903515

calcium ion transport from cytosol to endoplasmic reticulum

15028735


check buttonFusion gene breakpoints across ATP2A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ATP2A3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer2397NATP2A2chr12

110777208

+ATP2A3chr17

3844948

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000308664ATP2A2chr12110777208+ENST00000397035ATP2A3chr173844948-4725221632937601143
ENST00000308664ATP2A2chr12110777208+ENST00000397041ATP2A3chr173844948-5218221632936701113
ENST00000308664ATP2A2chr12110777208+ENST00000309890ATP2A3chr173844948-5319221632937601143
ENST00000395494ATP2A2chr12110777208+ENST00000397035ATP2A3chr173844948-4533202421835681116
ENST00000395494ATP2A2chr12110777208+ENST00000397041ATP2A3chr173844948-5026202421834781086
ENST00000395494ATP2A2chr12110777208+ENST00000309890ATP2A3chr173844948-5127202421835681116
ENST00000539276ATP2A2chr12110777208+ENST00000397035ATP2A3chr173844948-4160165110931951028
ENST00000539276ATP2A2chr12110777208+ENST00000397041ATP2A3chr173844948-465316511093105998
ENST00000539276ATP2A2chr12110777208+ENST00000309890ATP2A3chr173844948-4754165110931951028

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000308664ENST00000397035ATP2A2chr12110777208+ATP2A3chr173844948-0.0022857570.9977143
ENST00000308664ENST00000397041ATP2A2chr12110777208+ATP2A3chr173844948-0.0030595590.9969405
ENST00000308664ENST00000309890ATP2A2chr12110777208+ATP2A3chr173844948-0.0019566040.9980434
ENST00000395494ENST00000397035ATP2A2chr12110777208+ATP2A3chr173844948-0.0023894020.99761057
ENST00000395494ENST00000397041ATP2A2chr12110777208+ATP2A3chr173844948-0.0021352530.9978648
ENST00000395494ENST00000309890ATP2A2chr12110777208+ATP2A3chr173844948-0.0019752330.9980248
ENST00000539276ENST00000397035ATP2A2chr12110777208+ATP2A3chr173844948-0.0014262690.9985738
ENST00000539276ENST00000397041ATP2A2chr12110777208+ATP2A3chr173844948-0.0018454920.99815446
ENST00000539276ENST00000309890ATP2A2chr12110777208+ATP2A3chr173844948-0.0011711950.9988288

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>7827_7827_1_ATP2A2-ATP2A3_ATP2A2_chr12_110777208_ENST00000308664_ATP2A3_chr17_3844948_ENST00000309890_length(amino acids)=1143AA_BP=160
MIASRERGGGSGAAACPPGGRLRAREALPSGEGREGGSGAPNPPCGARGRARGGCLGEGARGDSAPGEAEAAARGGGESPSAPGLPGWHE
PAAGVRGGGEEAAGTGGEAGRAPEAMENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRIL
LLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAV
GDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQE
RTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRS
LPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSAL
DYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKG
APESVIERCSSVRVGSRTAPLTPTSREQILAKIRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPE
VAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNE
ITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEA
LIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKC
SEDNPLFAGIDCEVFESRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQ

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>7827_7827_2_ATP2A2-ATP2A3_ATP2A2_chr12_110777208_ENST00000308664_ATP2A3_chr17_3844948_ENST00000397035_length(amino acids)=1143AA_BP=160
MIASRERGGGSGAAACPPGGRLRAREALPSGEGREGGSGAPNPPCGARGRARGGCLGEGARGDSAPGEAEAAARGGGESPSAPGLPGWHE
PAAGVRGGGEEAAGTGGEAGRAPEAMENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRIL
LLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAV
GDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQE
RTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRS
LPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSAL
DYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKG
APESVIERCSSVRVGSRTAPLTPTSREQILAKIRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPE
VAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNE
ITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEA
LIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKC
SEDNPLFAGIDCEVFESRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQ

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>7827_7827_3_ATP2A2-ATP2A3_ATP2A2_chr12_110777208_ENST00000308664_ATP2A3_chr17_3844948_ENST00000397041_length(amino acids)=1113AA_BP=160
MIASRERGGGSGAAACPPGGRLRAREALPSGEGREGGSGAPNPPCGARGRARGGCLGEGARGDSAPGEAEAAARGGGESPSAPGLPGWHE
PAAGVRGGGEEAAGTGGEAGRAPEAMENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRIL
LLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAV
GDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQE
RTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRS
LPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSAL
DYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKG
APESVIERCSSVRVGSRTAPLTPTSREQILAKIRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPE
VAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNE
ITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEA
LIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKC
SEDNPLFAGIDCEVFESRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQ

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>7827_7827_4_ATP2A2-ATP2A3_ATP2A2_chr12_110777208_ENST00000395494_ATP2A3_chr17_3844948_ENST00000309890_length(amino acids)=1116AA_BP=160
MIASRERGGGSGAAACPPGGRLRAREALPSGEGREGGSGAPNPPCGARGRARGGCLGEGARGDSAPGEAEAAARGGGESPSAPGLPGWHE
PAAGVRGGGEEAAGTGGEAGRAPEAMENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRIL
LLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAG
ESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVW
IINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMS
VCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKM
NVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSRE
QILAKIRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAV
AICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSG
TAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPD
LDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMALSV
LVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSRNHMH

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>7827_7827_5_ATP2A2-ATP2A3_ATP2A2_chr12_110777208_ENST00000395494_ATP2A3_chr17_3844948_ENST00000397035_length(amino acids)=1116AA_BP=160
MIASRERGGGSGAAACPPGGRLRAREALPSGEGREGGSGAPNPPCGARGRARGGCLGEGARGDSAPGEAEAAARGGGESPSAPGLPGWHE
PAAGVRGGGEEAAGTGGEAGRAPEAMENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRIL
LLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAG
ESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVW
IINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMS
VCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKM
NVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSRE
QILAKIRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAV
AICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSG
TAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPD
LDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMALSV
LVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSRNHMH

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>7827_7827_6_ATP2A2-ATP2A3_ATP2A2_chr12_110777208_ENST00000395494_ATP2A3_chr17_3844948_ENST00000397041_length(amino acids)=1086AA_BP=160
MIASRERGGGSGAAACPPGGRLRAREALPSGEGREGGSGAPNPPCGARGRARGGCLGEGARGDSAPGEAEAAARGGGESPSAPGLPGWHE
PAAGVRGGGEEAAGTGGEAGRAPEAMENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRIL
LLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAG
ESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVW
IINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMS
VCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKM
NVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSRE
QILAKIRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAV
AICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSG
TAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPD
LDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMALSV
LVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSRNHMH

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>7827_7827_7_ATP2A2-ATP2A3_ATP2A2_chr12_110777208_ENST00000539276_ATP2A3_chr17_3844948_ENST00000309890_length(amino acids)=1028AA_BP=45
MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVE
PFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSIL
TGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIA
VWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQ
MSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVE
KMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPESVIERCSSVRVGSRTAPLTPTS
REQILAKIRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGT
AVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG
SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNP
PDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMAL
SVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSRNH

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>7827_7827_8_ATP2A2-ATP2A3_ATP2A2_chr12_110777208_ENST00000539276_ATP2A3_chr17_3844948_ENST00000397035_length(amino acids)=1028AA_BP=45
MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVE
PFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSIL
TGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIA
VWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQ
MSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVE
KMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPESVIERCSSVRVGSRTAPLTPTS
REQILAKIRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGT
AVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG
SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNP
PDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMAL
SVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSRNH

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>7827_7827_9_ATP2A2-ATP2A3_ATP2A2_chr12_110777208_ENST00000539276_ATP2A3_chr17_3844948_ENST00000397041_length(amino acids)=998AA_BP=45
MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVE
PFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSIL
TGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIA
VWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQ
MSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVE
KMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPESVIERCSSVRVGSRTAPLTPTS
REQILAKIRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGT
AVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG
SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNP
PDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMAL
SVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSRNH

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:110777208/chr17:3844948)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP2A2

P16615

ATP2A3

Q93084

FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). {ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}.FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. {ECO:0000269|PubMed:11956212, ECO:0000269|PubMed:15028735}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+1221111_253514.0998.0Topological domainCytoplasmic
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+12211_48514.0998.0Topological domainCytoplasmic
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+1221274_295514.0998.0Topological domainLumenal
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+122170_89514.0998.0Topological domainLumenal
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+1119111_253487.01016.0Topological domainCytoplasmic
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+11191_48487.01016.0Topological domainCytoplasmic
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+1119274_295487.01016.0Topological domainLumenal
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+111970_89487.01016.0Topological domainLumenal
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+1220111_253514.01043.0Topological domainCytoplasmic
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+12201_48514.01043.0Topological domainCytoplasmic
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+1220274_295514.01043.0Topological domainLumenal
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+122070_89514.01043.0Topological domainLumenal
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+1221254_273514.0998.0TransmembraneHelical%3B Name%3D3
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+1221296_313514.0998.0TransmembraneHelical%3B Name%3D4
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+122149_69514.0998.0TransmembraneHelical%3B Name%3D1
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+122190_110514.0998.0TransmembraneHelical%3B Name%3D2
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+1119254_273487.01016.0TransmembraneHelical%3B Name%3D3
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+1119296_313487.01016.0TransmembraneHelical%3B Name%3D4
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+111949_69487.01016.0TransmembraneHelical%3B Name%3D1
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+111990_110487.01016.0TransmembraneHelical%3B Name%3D2
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+1220254_273514.01043.0TransmembraneHelical%3B Name%3D3
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+1220296_313514.01043.0TransmembraneHelical%3B Name%3D4
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+122049_69514.01043.0TransmembraneHelical%3B Name%3D1
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+122090_110514.01043.0TransmembraneHelical%3B Name%3D2
TgeneATP2A3chr12:110777208chr17:3844948ENST000003098901122778_787515.01030.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003098901122809_828515.01030.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003098901122852_897515.01030.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003098901122918_930515.01030.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003098901122950_964515.01030.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003098901122986_999515.01030.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003520111122778_787515.01044.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003520111122809_828515.01044.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003520111122852_897515.01044.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003520111122918_930515.01044.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003520111122950_964515.01044.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003520111122986_999515.01044.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003599831123778_787515.01053.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003599831123809_828515.01053.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003599831123852_897515.01053.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003599831123918_930515.01053.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003599831123950_964515.01053.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003599831123986_999515.01053.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970351123778_787515.01266.3333333333333Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970351123809_828515.01266.3333333333333Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970351123852_897515.01266.3333333333333Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970351123918_930515.01266.3333333333333Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970351123950_964515.01266.3333333333333Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970351123986_999515.01266.3333333333333Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970411121778_787515.01000.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970411121809_828515.01000.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970411121852_897515.01000.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970411121918_930515.01000.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970411121950_964515.01000.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970411121986_999515.01000.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970431121778_787515.0999.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970431121809_828515.0999.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970431121852_897515.0999.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970431121918_930515.0999.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970431121950_964515.0999.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970431121986_999515.0999.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003098901122758_777515.01030.0TransmembraneHelical%3B Name%3D5
TgeneATP2A3chr12:110777208chr17:3844948ENST000003098901122829_851515.01030.0TransmembraneHelical%3B Name%3D7
TgeneATP2A3chr12:110777208chr17:3844948ENST000003098901122898_917515.01030.0TransmembraneHelical%3B Name%3D8
TgeneATP2A3chr12:110777208chr17:3844948ENST000003098901122931_949515.01030.0TransmembraneHelical%3B Name%3D9
TgeneATP2A3chr12:110777208chr17:3844948ENST000003098901122965_985515.01030.0TransmembraneHelical%3B Name%3D10
TgeneATP2A3chr12:110777208chr17:3844948ENST000003520111122758_777515.01044.0TransmembraneHelical%3B Name%3D5
TgeneATP2A3chr12:110777208chr17:3844948ENST000003520111122829_851515.01044.0TransmembraneHelical%3B Name%3D7
TgeneATP2A3chr12:110777208chr17:3844948ENST000003520111122898_917515.01044.0TransmembraneHelical%3B Name%3D8
TgeneATP2A3chr12:110777208chr17:3844948ENST000003520111122931_949515.01044.0TransmembraneHelical%3B Name%3D9
TgeneATP2A3chr12:110777208chr17:3844948ENST000003520111122965_985515.01044.0TransmembraneHelical%3B Name%3D10
TgeneATP2A3chr12:110777208chr17:3844948ENST000003599831123758_777515.01053.0TransmembraneHelical%3B Name%3D5
TgeneATP2A3chr12:110777208chr17:3844948ENST000003599831123829_851515.01053.0TransmembraneHelical%3B Name%3D7
TgeneATP2A3chr12:110777208chr17:3844948ENST000003599831123898_917515.01053.0TransmembraneHelical%3B Name%3D8
TgeneATP2A3chr12:110777208chr17:3844948ENST000003599831123931_949515.01053.0TransmembraneHelical%3B Name%3D9
TgeneATP2A3chr12:110777208chr17:3844948ENST000003599831123965_985515.01053.0TransmembraneHelical%3B Name%3D10
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970351123758_777515.01266.3333333333333TransmembraneHelical%3B Name%3D5
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970351123829_851515.01266.3333333333333TransmembraneHelical%3B Name%3D7
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970351123898_917515.01266.3333333333333TransmembraneHelical%3B Name%3D8
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970351123931_949515.01266.3333333333333TransmembraneHelical%3B Name%3D9
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970351123965_985515.01266.3333333333333TransmembraneHelical%3B Name%3D10
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970411121758_777515.01000.0TransmembraneHelical%3B Name%3D5
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970411121829_851515.01000.0TransmembraneHelical%3B Name%3D7
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970411121898_917515.01000.0TransmembraneHelical%3B Name%3D8
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970411121931_949515.01000.0TransmembraneHelical%3B Name%3D9
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970411121965_985515.01000.0TransmembraneHelical%3B Name%3D10
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970431121758_777515.0999.0TransmembraneHelical%3B Name%3D5
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970431121829_851515.0999.0TransmembraneHelical%3B Name%3D7
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970431121898_917515.0999.0TransmembraneHelical%3B Name%3D8
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970431121931_949515.0999.0TransmembraneHelical%3B Name%3D9
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970431121965_985515.0999.0TransmembraneHelical%3B Name%3D10

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+1221314_756514.0998.0Topological domainCytoplasmic
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+1221777_786514.0998.0Topological domainLumenal
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+1221808_827514.0998.0Topological domainCytoplasmic
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+1221851_896514.0998.0Topological domainLumenal
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+1221917_929514.0998.0Topological domainCytoplasmic
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+1221949_963514.0998.0Topological domainLumenal
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+1221985_1042514.0998.0Topological domainCytoplasmic
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+1119314_756487.01016.0Topological domainCytoplasmic
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+1119777_786487.01016.0Topological domainLumenal
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+1119808_827487.01016.0Topological domainCytoplasmic
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+1119851_896487.01016.0Topological domainLumenal
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+1119917_929487.01016.0Topological domainCytoplasmic
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+1119949_963487.01016.0Topological domainLumenal
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+1119985_1042487.01016.0Topological domainCytoplasmic
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+1220314_756514.01043.0Topological domainCytoplasmic
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+1220777_786514.01043.0Topological domainLumenal
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+1220808_827514.01043.0Topological domainCytoplasmic
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+1220851_896514.01043.0Topological domainLumenal
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+1220917_929514.01043.0Topological domainCytoplasmic
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+1220949_963514.01043.0Topological domainLumenal
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+1220985_1042514.01043.0Topological domainCytoplasmic
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+1221757_776514.0998.0TransmembraneHelical%3B Name%3D5
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+1221828_850514.0998.0TransmembraneHelical%3B Name%3D7
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+1221897_916514.0998.0TransmembraneHelical%3B Name%3D8
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+1221930_948514.0998.0TransmembraneHelical%3B Name%3D9
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+1221964_984514.0998.0TransmembraneHelical%3B Name%3D10
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+1119757_776487.01016.0TransmembraneHelical%3B Name%3D5
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+1119828_850487.01016.0TransmembraneHelical%3B Name%3D7
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+1119897_916487.01016.0TransmembraneHelical%3B Name%3D8
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+1119930_948487.01016.0TransmembraneHelical%3B Name%3D9
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+1119964_984487.01016.0TransmembraneHelical%3B Name%3D10
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+1220757_776514.01043.0TransmembraneHelical%3B Name%3D5
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+1220828_850514.01043.0TransmembraneHelical%3B Name%3D7
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+1220897_916514.01043.0TransmembraneHelical%3B Name%3D8
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+1220930_948514.01043.0TransmembraneHelical%3B Name%3D9
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+1220964_984514.01043.0TransmembraneHelical%3B Name%3D10
TgeneATP2A3chr12:110777208chr17:3844948ENST000003098901122111_253515.01030.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST0000030989011221_48515.01030.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003098901122274_295515.01030.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003098901122314_757515.01030.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST00000309890112270_89515.01030.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003520111122111_253515.01044.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST0000035201111221_48515.01044.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003520111122274_295515.01044.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003520111122314_757515.01044.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST00000352011112270_89515.01044.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003599831123111_253515.01053.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST0000035998311231_48515.01053.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003599831123274_295515.01053.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003599831123314_757515.01053.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST00000359983112370_89515.01053.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970351123111_253515.01266.3333333333333Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST0000039703511231_48515.01266.3333333333333Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970351123274_295515.01266.3333333333333Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970351123314_757515.01266.3333333333333Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST00000397035112370_89515.01266.3333333333333Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970411121111_253515.01000.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST0000039704111211_48515.01000.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970411121274_295515.01000.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970411121314_757515.01000.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST00000397041112170_89515.01000.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970431121111_253515.0999.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST0000039704311211_48515.0999.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970431121274_295515.0999.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970431121314_757515.0999.0Topological domainCytoplasmic
TgeneATP2A3chr12:110777208chr17:3844948ENST00000397043112170_89515.0999.0Topological domainLumenal
TgeneATP2A3chr12:110777208chr17:3844948ENST000003098901122254_273515.01030.0TransmembraneHelical%3B Name%3D3
TgeneATP2A3chr12:110777208chr17:3844948ENST000003098901122296_313515.01030.0TransmembraneHelical%3B Name%3D4
TgeneATP2A3chr12:110777208chr17:3844948ENST00000309890112249_69515.01030.0TransmembraneHelical%3B Name%3D1
TgeneATP2A3chr12:110777208chr17:3844948ENST00000309890112290_110515.01030.0TransmembraneHelical%3B Name%3D2
TgeneATP2A3chr12:110777208chr17:3844948ENST000003520111122254_273515.01044.0TransmembraneHelical%3B Name%3D3
TgeneATP2A3chr12:110777208chr17:3844948ENST000003520111122296_313515.01044.0TransmembraneHelical%3B Name%3D4
TgeneATP2A3chr12:110777208chr17:3844948ENST00000352011112249_69515.01044.0TransmembraneHelical%3B Name%3D1
TgeneATP2A3chr12:110777208chr17:3844948ENST00000352011112290_110515.01044.0TransmembraneHelical%3B Name%3D2
TgeneATP2A3chr12:110777208chr17:3844948ENST000003599831123254_273515.01053.0TransmembraneHelical%3B Name%3D3
TgeneATP2A3chr12:110777208chr17:3844948ENST000003599831123296_313515.01053.0TransmembraneHelical%3B Name%3D4
TgeneATP2A3chr12:110777208chr17:3844948ENST00000359983112349_69515.01053.0TransmembraneHelical%3B Name%3D1
TgeneATP2A3chr12:110777208chr17:3844948ENST00000359983112390_110515.01053.0TransmembraneHelical%3B Name%3D2
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970351123254_273515.01266.3333333333333TransmembraneHelical%3B Name%3D3
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970351123296_313515.01266.3333333333333TransmembraneHelical%3B Name%3D4
TgeneATP2A3chr12:110777208chr17:3844948ENST00000397035112349_69515.01266.3333333333333TransmembraneHelical%3B Name%3D1
TgeneATP2A3chr12:110777208chr17:3844948ENST00000397035112390_110515.01266.3333333333333TransmembraneHelical%3B Name%3D2
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970411121254_273515.01000.0TransmembraneHelical%3B Name%3D3
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970411121296_313515.01000.0TransmembraneHelical%3B Name%3D4
TgeneATP2A3chr12:110777208chr17:3844948ENST00000397041112149_69515.01000.0TransmembraneHelical%3B Name%3D1
TgeneATP2A3chr12:110777208chr17:3844948ENST00000397041112190_110515.01000.0TransmembraneHelical%3B Name%3D2
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970431121254_273515.0999.0TransmembraneHelical%3B Name%3D3
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970431121296_313515.0999.0TransmembraneHelical%3B Name%3D4
TgeneATP2A3chr12:110777208chr17:3844948ENST00000397043112149_69515.0999.0TransmembraneHelical%3B Name%3D1
TgeneATP2A3chr12:110777208chr17:3844948ENST00000397043112190_110515.0999.0TransmembraneHelical%3B Name%3D2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ATP2A2
ATP2A3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+1221575_594514.0998.0HAX1
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+1119575_594487.01016.0HAX1
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+1220575_594514.01043.0HAX1
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+1221787_807514.0998.0PLN
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+1221931_942514.0998.0PLN
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+1119787_807487.01016.0PLN
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+1119931_942487.01016.0PLN
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+1220787_807514.01043.0PLN
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+1220931_942514.01043.0PLN
HgeneATP2A2chr12:110777208chr17:3844948ENST00000308664+1221788_1042514.0998.0TMEM64 and PDIA3
HgeneATP2A2chr12:110777208chr17:3844948ENST00000395494+1119788_1042487.01016.0TMEM64 and PDIA3
HgeneATP2A2chr12:110777208chr17:3844948ENST00000539276+1220788_1042514.01043.0TMEM64 and PDIA3
TgeneATP2A3chr12:110777208chr17:3844948ENST000003098901122370_400515.01030.0phospholamban 1
TgeneATP2A3chr12:110777208chr17:3844948ENST000003520111122370_400515.01044.0phospholamban 1
TgeneATP2A3chr12:110777208chr17:3844948ENST000003599831123370_400515.01053.0phospholamban 1
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970351123370_400515.01266.3333333333333phospholamban 1
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970411121370_400515.01000.0phospholamban 1
TgeneATP2A3chr12:110777208chr17:3844948ENST000003970431121370_400515.0999.0phospholamban 1


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Related Drugs to ATP2A2-ATP2A3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ATP2A2-ATP2A3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource