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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ATP2A2-COL2A1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ATP2A2-COL2A1
FusionPDB ID: 7832
FusionGDB2.0 ID: 7832
HgeneTgene
Gene symbol

ATP2A2

COL2A1

Gene ID

488

1280

Gene nameATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2collagen type II alpha 1 chain
SynonymsATP2B|DAR|DD|SERCA2ANFH|AOM|COL11A3|SEDC|STL1
Cytomap

12q24.11

12q13.11

Type of geneprotein-codingprotein-coding
Descriptionsarcoplasmic/endoplasmic reticulum calcium ATPase 2ATPase Ca++ transporting cardiac muscle slow twitch 2ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2SR Ca(2+)-ATPase 2calcium pump 2calcium-transporting ATPase sarcoplasmic reticulum type, slowcollagen alpha-1(II) chainalpha-1 type II collagenarthroophthalmopathy, progressive (Stickler syndrome)cartilage collagenchondrocalcincollagen II, alpha-1 polypeptidecollagen, type II, alpha 1
Modification date2020031320200328
UniProtAcc

P16615

P02458

Ensembl transtripts involved in fusion geneENST idsENST00000308664, ENST00000395494, 
ENST00000539276, ENST00000550248, 
ENST00000552636, 		ENST00000337299, 
ENST00000493991, ENST00000380518, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 22 X 11=41148 X 9 X 4=288
# samples 2710
** MAII scorelog2(27/4114*10)=-3.9295104814741
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/288*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ATP2A2 [Title/Abstract] AND COL2A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ATP2A2(110771948)-COL2A1(48378382), # samples:2
Anticipated loss of major functional domain due to fusion event.ATP2A2-COL2A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP2A2-COL2A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP2A2-COL2A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP2A2-COL2A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATP2A2

GO:0032469

endoplasmic reticulum calcium ion homeostasis

16402920

HgeneATP2A2

GO:0032470

positive regulation of endoplasmic reticulum calcium ion concentration

16402920

HgeneATP2A2

GO:0070588

calcium ion transmembrane transport

16402920

HgeneATP2A2

GO:1903515

calcium ion transport from cytosol to endoplasmic reticulum

16402920


check buttonFusion gene breakpoints across ATP2A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across COL2A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-3B-A9HL-01AATP2A2chr12

110771948

-COL2A1chr12

48378382

-
ChimerDB4SARCTCGA-3B-A9HL-01AATP2A2chr12

110771948

+COL2A1chr12

48378382

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000308664ATP2A2chr12110771948+ENST00000380518COL2A1chr1248378382-5166209332947231464
ENST00000395494ATP2A2chr12110771948+ENST00000380518COL2A1chr1248378382-4974190121845311437
ENST00000539276ATP2A2chr12110771948+ENST00000380518COL2A1chr1248378382-4601152810941581349

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000308664ENST00000380518ATP2A2chr12110771948+COL2A1chr1248378382-0.001779490.9982205
ENST00000395494ENST00000380518ATP2A2chr12110771948+COL2A1chr1248378382-0.0017415970.9982584
ENST00000539276ENST00000380518ATP2A2chr12110771948+COL2A1chr1248378382-0.0010293520.9989706

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>7832_7832_1_ATP2A2-COL2A1_ATP2A2_chr12_110771948_ENST00000308664_COL2A1_chr12_48378382_ENST00000380518_length(amino acids)=1464AA_BP=924
MIASRERGGGSGAAACPPGGRLRAREALPSGEGREGGSGAPNPPCGARGRARGGCLGEGARGDSAPGEAEAAARGGGESPSAPGLPGWHE
PAAGVRGGGEEAAGTGGEAGRAPEAMENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRIL
LLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAV
GDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQE
RTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRS
LPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSAL
DYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGER
GEQGAPGPSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPGAQGLQGPRGLPGTPGTDGPKGASGPAGPPGAQ
GPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETGPPGPA
GFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGPS
GKDGPKGARGDSGPPGRAGEPGLQGPAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGAS
GDRGPPGPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPA
GARGIQGPQGPRGDKGEAGEPGERGLKGHRGFTGLQGLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGIPGPIGPPGPRGRS
GETGPAGPPGNPGPPGPPGPPGPGIDMSAFAGLGPREKGPDPLQYMRADQAAGGLRQHDAEVDATLKSLNNQIESIRSPEGSRKNPARTC
RDLKLCHPEWKSGDYWIDPNQGCTLDAMKVFCNMETGETCVYPNPANVPKKNWWSSKSKEKKHIWFGETINGGFHFSYGDDNLAPNTANV
QMTFLRLLSTEGSQNITYHCKNSIAYLDEAAGNLKKALLIQGSNDVEIRAEGNSRFTYTALKDGCTKHTGKWGKTVIEYRSQKTSRLPII

--------------------------------------------------------------

>7832_7832_2_ATP2A2-COL2A1_ATP2A2_chr12_110771948_ENST00000395494_COL2A1_chr12_48378382_ENST00000380518_length(amino acids)=1437AA_BP=897
MIASRERGGGSGAAACPPGGRLRAREALPSGEGREGGSGAPNPPCGARGRARGGCLGEGARGDSAPGEAEAAARGGGESPSAPGLPGWHE
PAAGVRGGGEEAAGTGGEAGRAPEAMENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRIL
LLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAG
ESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVW
IINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMS
VCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKM
NVFDTELKGLSKIERANACNSGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGERGEQGAPGPSGFQGLPGPPGPPGEGGKP
GDQGVPGEAGAPGLVGPRGERGFPGERGSPGAQGLQGPRGLPGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGDV
GEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETGPPGPAGFAGPPGADGQPGAKGEQGEAGQKGDA
GAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGRAGEPGLQGPA
GPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPGPVGPPGLTGPAGEPGREGSP
GADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPGERGLK
GHRGFTGLQGLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGIPGPIGPPGPRGRSGETGPAGPPGNPGPPGPPGPPGPGIDM
SAFAGLGPREKGPDPLQYMRADQAAGGLRQHDAEVDATLKSLNNQIESIRSPEGSRKNPARTCRDLKLCHPEWKSGDYWIDPNQGCTLDA
MKVFCNMETGETCVYPNPANVPKKNWWSSKSKEKKHIWFGETINGGFHFSYGDDNLAPNTANVQMTFLRLLSTEGSQNITYHCKNSIAYL

--------------------------------------------------------------

>7832_7832_3_ATP2A2-COL2A1_ATP2A2_chr12_110771948_ENST00000539276_COL2A1_chr12_48378382_ENST00000380518_length(amino acids)=1349AA_BP=809
MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVE
PFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSIL
TGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIA
VWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQ
MSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVE
KMNVFDTELKGLSKIERANACNSGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGERGEQGAPGPSGFQGLPGPPGPPGEGG
KPGDQGVPGEAGAPGLVGPRGERGFPGERGSPGAQGLQGPRGLPGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRG
DVGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETGPPGPAGFAGPPGADGQPGAKGEQGEAGQKG
DAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGRAGEPGLQG
PAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPGPVGPPGLTGPAGEPGREG
SPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPGERG
LKGHRGFTGLQGLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGIPGPIGPPGPRGRSGETGPAGPPGNPGPPGPPGPPGPGI
DMSAFAGLGPREKGPDPLQYMRADQAAGGLRQHDAEVDATLKSLNNQIESIRSPEGSRKNPARTCRDLKLCHPEWKSGDYWIDPNQGCTL
DAMKVFCNMETGETCVYPNPANVPKKNWWSSKSKEKKHIWFGETINGGFHFSYGDDNLAPNTANVQMTFLRLLSTEGSQNITYHCKNSIA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:110771948/chr12:48378382)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP2A2

P16615

COL2A1

P02458

FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). {ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}.FUNCTION: Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+1121111_253473.0998.0Topological domainCytoplasmic
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+11211_48473.0998.0Topological domainCytoplasmic
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+1121274_295473.0998.0Topological domainLumenal
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+112170_89473.0998.0Topological domainLumenal
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+1019111_253446.01016.0Topological domainCytoplasmic
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+10191_48446.01016.0Topological domainCytoplasmic
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+1019274_295446.01016.0Topological domainLumenal
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+101970_89446.01016.0Topological domainLumenal
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+1120111_253473.01043.0Topological domainCytoplasmic
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+11201_48473.01043.0Topological domainCytoplasmic
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+1120274_295473.01043.0Topological domainLumenal
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+112070_89473.01043.0Topological domainLumenal
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+1121254_273473.0998.0TransmembraneHelical%3B Name%3D3
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+1121296_313473.0998.0TransmembraneHelical%3B Name%3D4
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+112149_69473.0998.0TransmembraneHelical%3B Name%3D1
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+112190_110473.0998.0TransmembraneHelical%3B Name%3D2
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+1019254_273446.01016.0TransmembraneHelical%3B Name%3D3
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+1019296_313446.01016.0TransmembraneHelical%3B Name%3D4
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+101949_69446.01016.0TransmembraneHelical%3B Name%3D1
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+101990_110446.01016.0TransmembraneHelical%3B Name%3D2
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+1120254_273473.01043.0TransmembraneHelical%3B Name%3D3
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+1120296_313473.01043.0TransmembraneHelical%3B Name%3D4
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+112049_69473.01043.0TransmembraneHelical%3B Name%3D1
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+112090_110473.01043.0TransmembraneHelical%3B Name%3D2
TgeneCOL2A1chr12:110771948chr12:48378382ENST0000033729925531253_1487542.01419.0DomainFibrillar collagen NC1
TgeneCOL2A1chr12:110771948chr12:48378382ENST0000038051826541253_1487611.01488.0DomainFibrillar collagen NC1
TgeneCOL2A1chr12:110771948chr12:48378382ENST0000033729925531215_1241542.01419.0RegionNote=Nonhelical region (C-terminal)
TgeneCOL2A1chr12:110771948chr12:48378382ENST0000038051826541215_1241611.01488.0RegionNote=Nonhelical region (C-terminal)

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+1121314_756473.0998.0Topological domainCytoplasmic
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+1121777_786473.0998.0Topological domainLumenal
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+1121808_827473.0998.0Topological domainCytoplasmic
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+1121851_896473.0998.0Topological domainLumenal
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+1121917_929473.0998.0Topological domainCytoplasmic
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+1121949_963473.0998.0Topological domainLumenal
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+1121985_1042473.0998.0Topological domainCytoplasmic
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+1019314_756446.01016.0Topological domainCytoplasmic
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+1019777_786446.01016.0Topological domainLumenal
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+1019808_827446.01016.0Topological domainCytoplasmic
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+1019851_896446.01016.0Topological domainLumenal
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+1019917_929446.01016.0Topological domainCytoplasmic
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+1019949_963446.01016.0Topological domainLumenal
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+1019985_1042446.01016.0Topological domainCytoplasmic
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+1120314_756473.01043.0Topological domainCytoplasmic
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+1120777_786473.01043.0Topological domainLumenal
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+1120808_827473.01043.0Topological domainCytoplasmic
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+1120851_896473.01043.0Topological domainLumenal
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+1120917_929473.01043.0Topological domainCytoplasmic
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+1120949_963473.01043.0Topological domainLumenal
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+1120985_1042473.01043.0Topological domainCytoplasmic
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+1121757_776473.0998.0TransmembraneHelical%3B Name%3D5
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+1121828_850473.0998.0TransmembraneHelical%3B Name%3D7
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+1121897_916473.0998.0TransmembraneHelical%3B Name%3D8
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+1121930_948473.0998.0TransmembraneHelical%3B Name%3D9
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+1121964_984473.0998.0TransmembraneHelical%3B Name%3D10
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+1019757_776446.01016.0TransmembraneHelical%3B Name%3D5
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+1019828_850446.01016.0TransmembraneHelical%3B Name%3D7
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+1019897_916446.01016.0TransmembraneHelical%3B Name%3D8
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+1019930_948446.01016.0TransmembraneHelical%3B Name%3D9
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+1019964_984446.01016.0TransmembraneHelical%3B Name%3D10
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+1120757_776473.01043.0TransmembraneHelical%3B Name%3D5
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+1120828_850473.01043.0TransmembraneHelical%3B Name%3D7
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+1120897_916473.01043.0TransmembraneHelical%3B Name%3D8
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+1120930_948473.01043.0TransmembraneHelical%3B Name%3D9
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+1120964_984473.01043.0TransmembraneHelical%3B Name%3D10
TgeneCOL2A1chr12:110771948chr12:48378382ENST00000337299255332_90542.01419.0DomainVWFC
TgeneCOL2A1chr12:110771948chr12:48378382ENST00000380518265432_90611.01488.0DomainVWFC
TgeneCOL2A1chr12:110771948chr12:48378382ENST000003372992553201_1214542.01419.0RegionNote=Triple-helical region
TgeneCOL2A1chr12:110771948chr12:48378382ENST000003805182654201_1214611.01488.0RegionNote=Triple-helical region


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ATP2A2
COL2A1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+1121575_594473.0998.0HAX1
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+1019575_594446.01016.0HAX1
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+1120575_594473.01043.0HAX1
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+1121787_807473.0998.0PLN
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+1121931_942473.0998.0PLN
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+1019787_807446.01016.0PLN
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+1019931_942446.01016.0PLN
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+1120787_807473.01043.0PLN
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+1120931_942473.01043.0PLN
HgeneATP2A2chr12:110771948chr12:48378382ENST00000308664+1121788_1042473.0998.0TMEM64 and PDIA3
HgeneATP2A2chr12:110771948chr12:48378382ENST00000395494+1019788_1042446.01016.0TMEM64 and PDIA3
HgeneATP2A2chr12:110771948chr12:48378382ENST00000539276+1120788_1042473.01043.0TMEM64 and PDIA3


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Related Drugs to ATP2A2-COL2A1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ATP2A2-COL2A1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource