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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:RSF1-ADAM2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RSF1-ADAM2
FusionPDB ID: 78391
FusionGDB2.0 ID: 78391
HgeneTgene
Gene symbol

RSF1

ADAM2

Gene ID

51773

2515

Gene nameremodeling and spacing factor 1ADAM metallopeptidase domain 2
SynonymsHBXAP|RSF-1|XAP8|p325CRYN1|CRYN2|CT15|FTNB|PH-30b|PH30|PH30-beta
Cytomap

11q14.1

8p11.22

Type of geneprotein-codingprotein-coding
Descriptionremodeling and spacing factor 1HBV pX-associated protein 8hepatitis B virus x-associated proteinp325 subunit of RSF chromatin-remodeling complexdisintegrin and metalloproteinase domain-containing protein 2cancer/testis antigen 15fertilin subunit beta
Modification date2020031320200313
UniProtAcc.

Q9UKF5

Ensembl transtripts involved in fusion geneENST idsENST00000308488, ENST00000360355, 
ENST00000480887, ENST00000530604, 
ENST00000523181, ENST00000265708, 
ENST00000347580, ENST00000379853, 
ENST00000521880, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score24 X 20 X 11=52807 X 8 X 4=224
# samples 3210
** MAII scorelog2(32/5280*10)=-4.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/224*10)=-1.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RSF1 [Title/Abstract] AND ADAM2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RSF1(77458081)-ADAM2(39607263), # samples:3
Anticipated loss of major functional domain due to fusion event.RSF1-ADAM2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RSF1-ADAM2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RSF1-ADAM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RSF1-ADAM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRSF1

GO:0006334

nucleosome assembly

12972596

HgeneRSF1

GO:0006338

chromatin remodeling

9836642

HgeneRSF1

GO:0006352

DNA-templated transcription, initiation

9836642

HgeneRSF1

GO:0016584

nucleosome positioning

9836642

HgeneRSF1

GO:0043392

negative regulation of DNA binding

12972596

HgeneRSF1

GO:0045892

negative regulation of transcription, DNA-templated

11944984

HgeneRSF1

GO:0045893

positive regulation of transcription, DNA-templated

11788598

HgeneRSF1

GO:0050434

positive regulation of viral transcription

11788598


check buttonFusion gene breakpoints across RSF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ADAM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-XX-A899-01ARSF1chr11

77458081

-ADAM2chr8

39607263

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000308488RSF1chr1177458081-ENST00000347580ADAM2chr839607263-14466753031085260
ENST00000308488RSF1chr1177458081-ENST00000379853ADAM2chr839607263-14466753031085260
ENST00000308488RSF1chr1177458081-ENST00000265708ADAM2chr839607263-14466753031085260
ENST00000308488RSF1chr1177458081-ENST00000521880ADAM2chr839607263-11506753031085260

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000308488ENST00000347580RSF1chr1177458081-ADAM2chr839607263-0.001664740.9983353
ENST00000308488ENST00000379853RSF1chr1177458081-ADAM2chr839607263-0.001664740.9983353
ENST00000308488ENST00000265708RSF1chr1177458081-ADAM2chr839607263-0.001664740.9983353
ENST00000308488ENST00000521880RSF1chr1177458081-ADAM2chr839607263-0.0037738910.9962261

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>78391_78391_1_RSF1-ADAM2_RSF1_chr11_77458081_ENST00000308488_ADAM2_chr8_39607263_ENST00000265708_length(amino acids)=260AA_BP=124
MATAAAAAAVMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPPPDVGNGEVPKELVELHLKLMRKIGKSVTADRWEKY
LIKICQEFNSTWAWEMEKKGYLEMSVECKLALLKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGS

--------------------------------------------------------------

>78391_78391_2_RSF1-ADAM2_RSF1_chr11_77458081_ENST00000308488_ADAM2_chr8_39607263_ENST00000347580_length(amino acids)=260AA_BP=124
MATAAAAAAVMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPPPDVGNGEVPKELVELHLKLMRKIGKSVTADRWEKY
LIKICQEFNSTWAWEMEKKGYLEMSVECKLALLKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGS

--------------------------------------------------------------

>78391_78391_3_RSF1-ADAM2_RSF1_chr11_77458081_ENST00000308488_ADAM2_chr8_39607263_ENST00000379853_length(amino acids)=260AA_BP=124
MATAAAAAAVMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPPPDVGNGEVPKELVELHLKLMRKIGKSVTADRWEKY
LIKICQEFNSTWAWEMEKKGYLEMSVECKLALLKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGS

--------------------------------------------------------------

>78391_78391_4_RSF1-ADAM2_RSF1_chr11_77458081_ENST00000308488_ADAM2_chr8_39607263_ENST00000521880_length(amino acids)=260AA_BP=124
MATAAAAAAVMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPPPDVGNGEVPKELVELHLKLMRKIGKSVTADRWEKY
LIKICQEFNSTWAWEMEKKGYLEMSVECKLALLKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGS

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:77458081/chr8:39607263)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ADAM2

Q9UKF5

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRSF1chr11:77458081chr8:39607263ENST00000308488-31617_84124.01442.0DomainNote=DDT
TgeneADAM2chr11:77458081chr8:39607263ENST000002657081521612_645599.0788.6666666666666DomainNote=EGF-like
TgeneADAM2chr11:77458081chr8:39607263ENST000003475801420612_645580.0796.3333333333334DomainNote=EGF-like
TgeneADAM2chr11:77458081chr8:39607263ENST000002657081521708_735599.0788.6666666666666Topological domainCytoplasmic
TgeneADAM2chr11:77458081chr8:39607263ENST000003475801420708_735580.0796.3333333333334Topological domainCytoplasmic
TgeneADAM2chr11:77458081chr8:39607263ENST000002657081521687_707599.0788.6666666666666TransmembraneHelical
TgeneADAM2chr11:77458081chr8:39607263ENST000003475801420687_707580.0796.3333333333334TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRSF1chr11:77458081chr8:39607263ENST00000308488-316942_1012124.01442.0Coiled coilOntology_term=ECO:0000255
HgeneRSF1chr11:77458081chr8:39607263ENST00000360355-115942_101201411.0Coiled coilOntology_term=ECO:0000255
HgeneRSF1chr11:77458081chr8:39607263ENST00000480887-111942_101201190.0Coiled coilOntology_term=ECO:0000255
HgeneRSF1chr11:77458081chr8:39607263ENST00000308488-3161080_1083124.01442.0Compositional biasNote=Poly-Ala
HgeneRSF1chr11:77458081chr8:39607263ENST00000308488-3161146_1243124.01442.0Compositional biasNote=Arg-rich
HgeneRSF1chr11:77458081chr8:39607263ENST00000308488-3161286_1292124.01442.0Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77458081chr8:39607263ENST00000308488-3161419_1424124.01442.0Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77458081chr8:39607263ENST00000308488-316226_372124.01442.0Compositional biasNote=Glu-rich
HgeneRSF1chr11:77458081chr8:39607263ENST00000308488-316875_884124.01442.0Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77458081chr8:39607263ENST00000360355-1151080_108301411.0Compositional biasNote=Poly-Ala
HgeneRSF1chr11:77458081chr8:39607263ENST00000360355-1151146_124301411.0Compositional biasNote=Arg-rich
HgeneRSF1chr11:77458081chr8:39607263ENST00000360355-1151286_129201411.0Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77458081chr8:39607263ENST00000360355-1151419_142401411.0Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77458081chr8:39607263ENST00000360355-115226_37201411.0Compositional biasNote=Glu-rich
HgeneRSF1chr11:77458081chr8:39607263ENST00000360355-115875_88401411.0Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77458081chr8:39607263ENST00000480887-1111080_108301190.0Compositional biasNote=Poly-Ala
HgeneRSF1chr11:77458081chr8:39607263ENST00000480887-1111146_124301190.0Compositional biasNote=Arg-rich
HgeneRSF1chr11:77458081chr8:39607263ENST00000480887-1111286_129201190.0Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77458081chr8:39607263ENST00000480887-1111419_142401190.0Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77458081chr8:39607263ENST00000480887-111226_37201190.0Compositional biasNote=Glu-rich
HgeneRSF1chr11:77458081chr8:39607263ENST00000480887-111875_88401190.0Compositional biasNote=Poly-Glu
HgeneRSF1chr11:77458081chr8:39607263ENST00000360355-11517_8401411.0DomainNote=DDT
HgeneRSF1chr11:77458081chr8:39607263ENST00000480887-11117_8401190.0DomainNote=DDT
HgeneRSF1chr11:77458081chr8:39607263ENST00000308488-316891_941124.01442.0Zinc fingerPHD-type
HgeneRSF1chr11:77458081chr8:39607263ENST00000360355-115891_94101411.0Zinc fingerPHD-type
HgeneRSF1chr11:77458081chr8:39607263ENST00000480887-111891_94101190.0Zinc fingerPHD-type
TgeneADAM2chr11:77458081chr8:39607263ENST000002657081521477_606599.0788.6666666666666Compositional biasNote=Cys-rich
TgeneADAM2chr11:77458081chr8:39607263ENST000003475801420477_606580.0796.3333333333334Compositional biasNote=Cys-rich
TgeneADAM2chr11:77458081chr8:39607263ENST000002657081521178_375599.0788.6666666666666DomainPeptidase M12B
TgeneADAM2chr11:77458081chr8:39607263ENST000002657081521384_473599.0788.6666666666666DomainDisintegrin
TgeneADAM2chr11:77458081chr8:39607263ENST000003475801420178_375580.0796.3333333333334DomainPeptidase M12B
TgeneADAM2chr11:77458081chr8:39607263ENST000003475801420384_473580.0796.3333333333334DomainDisintegrin
TgeneADAM2chr11:77458081chr8:39607263ENST000002657081521175_686599.0788.6666666666666Topological domainExtracellular
TgeneADAM2chr11:77458081chr8:39607263ENST000003475801420175_686580.0796.3333333333334Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RSF1
ADAM2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to RSF1-ADAM2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RSF1-ADAM2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource