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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ATP2B1-LIN7A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ATP2B1-LIN7A
FusionPDB ID: 7856
FusionGDB2.0 ID: 7856
HgeneTgene
Gene symbol

ATP2B1

LIN7A

Gene ID

490

8825

Gene nameATPase plasma membrane Ca2+ transporting 1lin-7 homolog A, crumbs cell polarity complex component
SynonymsPMCA1|PMCA1kbLIN-7A|LIN7|MALS-1|MALS1|TIP-33|VELI1
Cytomap

12q21.33

12q21.31

Type of geneprotein-codingprotein-coding
Descriptionplasma membrane calcium-transporting ATPase 1ATPase, Ca++ transporting, plasma membrane 1plasma membrane calcium pumpprotein lin-7 homolog Amammalian lin-seven protein 1tax interaction protein 33vertebrate LIN7 homolog 1
Modification date2020032220200313
UniProtAcc

P20020

O14910

Ensembl transtripts involved in fusion geneENST idsENST00000261173, ENST00000348959, 
ENST00000359142, ENST00000393164, 
ENST00000428670, 		ENST00000552864, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 12 X 6=108012 X 5 X 4=240
# samples 137
** MAII scorelog2(13/1080*10)=-3.05444778402238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/240*10)=-1.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ATP2B1 [Title/Abstract] AND LIN7A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ATP2B1(90003714)-LIN7A(81283148), # samples:1
Anticipated loss of major functional domain due to fusion event.ATP2B1-LIN7A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP2B1-LIN7A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP2B1-LIN7A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP2B1-LIN7A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATP2B1

GO:0051480

regulation of cytosolic calcium ion concentration

18029012

HgeneATP2B1

GO:1990034

calcium ion export across plasma membrane

18029012


check buttonFusion gene breakpoints across ATP2B1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LIN7A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-3B-A9HO-01AATP2B1chr12

90003714

-LIN7Achr12

81283148

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000348959ATP2B1chr1290003714-ENST00000552864LIN7Achr1281283148-845026231812769862
ENST00000261173ATP2B1chr1290003714-ENST00000552864LIN7Achr1281283148-845026231812769862
ENST00000359142ATP2B1chr1290003714-ENST00000552864LIN7Achr1281283148-849426672252813862
ENST00000428670ATP2B1chr1290003714-ENST00000552864LIN7Achr1281283148-872628994573045862
ENST00000393164ATP2B1chr1290003714-ENST00000552864LIN7Achr1281283148-75911764931910605

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000348959ENST00000552864ATP2B1chr1290003714-LIN7Achr1281283148-0.0003837450.99961627
ENST00000261173ENST00000552864ATP2B1chr1290003714-LIN7Achr1281283148-0.0003837450.99961627
ENST00000359142ENST00000552864ATP2B1chr1290003714-LIN7Achr1281283148-0.0003799040.9996201
ENST00000428670ENST00000552864ATP2B1chr1290003714-LIN7Achr1281283148-0.000399610.99960035
ENST00000393164ENST00000552864ATP2B1chr1290003714-LIN7Achr1281283148-0.000119320.9998807

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>7856_7856_1_ATP2B1-LIN7A_ATP2B1_chr12_90003714_ENST00000261173_LIN7A_chr12_81283148_ENST00000552864_length(amino acids)=862AA_BP=814
MGDMANNSVAYSGVKNSLKEANHDGDFGITLAELRALMELRSTDALRKIQESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKNFI
PPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVGEEEGEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQ
FRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPLLLSGTHVMEGS
GRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKNKKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGDEKDKKKANLPKKEKS
VLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKM
MKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYKKVPEPEAIPPNILSYLVTGISVNCAYTSKILPPEKEGGLPRH
VGNKTECALLGLLLDLKRDYQDVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPRDRD
DIVKTVIEPMASEGLRTICLAFRDFPAGEPEPEWDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIAT
KCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSDQRQVVAVTGDGTNDGPALKKADV

--------------------------------------------------------------

>7856_7856_2_ATP2B1-LIN7A_ATP2B1_chr12_90003714_ENST00000348959_LIN7A_chr12_81283148_ENST00000552864_length(amino acids)=862AA_BP=814
MGDMANNSVAYSGVKNSLKEANHDGDFGITLAELRALMELRSTDALRKIQESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKNFI
PPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVGEEEGEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQ
FRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPLLLSGTHVMEGS
GRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKNKKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGDEKDKKKANLPKKEKS
VLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKM
MKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYKKVPEPEAIPPNILSYLVTGISVNCAYTSKILPPEKEGGLPRH
VGNKTECALLGLLLDLKRDYQDVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPRDRD
DIVKTVIEPMASEGLRTICLAFRDFPAGEPEPEWDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIAT
KCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSDQRQVVAVTGDGTNDGPALKKADV

--------------------------------------------------------------

>7856_7856_3_ATP2B1-LIN7A_ATP2B1_chr12_90003714_ENST00000359142_LIN7A_chr12_81283148_ENST00000552864_length(amino acids)=862AA_BP=814
MGDMANNSVAYSGVKNSLKEANHDGDFGITLAELRALMELRSTDALRKIQESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKNFI
PPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVGEEEGEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQ
FRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPLLLSGTHVMEGS
GRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKNKKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGDEKDKKKANLPKKEKS
VLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKM
MKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYKKVPEPEAIPPNILSYLVTGISVNCAYTSKILPPEKEGGLPRH
VGNKTECALLGLLLDLKRDYQDVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPRDRD
DIVKTVIEPMASEGLRTICLAFRDFPAGEPEPEWDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIAT
KCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSDQRQVVAVTGDGTNDGPALKKADV

--------------------------------------------------------------

>7856_7856_4_ATP2B1-LIN7A_ATP2B1_chr12_90003714_ENST00000393164_LIN7A_chr12_81283148_ENST00000552864_length(amino acids)=605AA_BP=557
MFLVIGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKNKKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGDEK
DKKKANLPKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPL
AVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYKKVPEPEAIPPNILSYLVTGISVNCAYTSK
ILPPEKEGGLPRHVGNKTECALLGLLLDLKRDYQDVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILSA
NGEAKVFRPRDRDDIVKTVIEPMASEGLRTICLAFRDFPAGEPEPEWDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMV
TGDNINTARAIATKCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSDQRQVVAVTGD

--------------------------------------------------------------

>7856_7856_5_ATP2B1-LIN7A_ATP2B1_chr12_90003714_ENST00000428670_LIN7A_chr12_81283148_ENST00000552864_length(amino acids)=862AA_BP=814
MGDMANNSVAYSGVKNSLKEANHDGDFGITLAELRALMELRSTDALRKIQESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKNFI
PPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVGEEEGEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQ
FRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPLLLSGTHVMEGS
GRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKNKKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGDEKDKKKANLPKKEKS
VLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKM
MKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYKKVPEPEAIPPNILSYLVTGISVNCAYTSKILPPEKEGGLPRH
VGNKTECALLGLLLDLKRDYQDVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPRDRD
DIVKTVIEPMASEGLRTICLAFRDFPAGEPEPEWDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIAT
KCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSDQRQVVAVTGDGTNDGPALKKADV

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:90003714/chr12:81283148)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP2B1

P20020

LIN7A

O14910

FUNCTION: Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (PubMed:29104511). {ECO:0000250|UniProtKB:G5E829, ECO:0000269|PubMed:29104511}.FUNCTION: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:Q8JZS0, ECO:0000269|PubMed:12967566}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-1420296_299814.01221.0Compositional biasNote=Poly-Glu
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-1419296_299814.01185.0Compositional biasNote=Poly-Glu
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-1421296_299814.01177.0Compositional biasNote=Poly-Glu
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-1521296_299814.01221.0Compositional biasNote=Poly-Glu
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-1420127_154814.01221.0Topological domainExtracellular
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-1420176_366814.01221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-14202_105814.01221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-1420387_418814.01221.0Topological domainExtracellular
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-1419127_154814.01185.0Topological domainExtracellular
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-1419176_366814.01185.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-14192_105814.01185.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-1419387_418814.01185.0Topological domainExtracellular
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-1421127_154814.01177.0Topological domainExtracellular
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-1421176_366814.01177.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-14212_105814.01177.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-1421387_418814.01177.0Topological domainExtracellular
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-1521127_154814.01221.0Topological domainExtracellular
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-1521176_366814.01221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-15212_105814.01221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-1521387_418814.01221.0Topological domainExtracellular
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-1420106_126814.01221.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-1420155_175814.01221.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-1420367_386814.01221.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-1420419_439814.01221.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-1419106_126814.01185.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-1419155_175814.01185.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-1419367_386814.01185.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-1419419_439814.01185.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-1421106_126814.01177.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-1421155_175814.01177.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-1421367_386814.01177.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-1421419_439814.01177.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-1521106_126814.01221.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-1521155_175814.01221.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-1521367_386814.01221.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-1521419_439814.01221.0TransmembraneHelical
TgeneLIN7Achr12:90003714chr12:81283148ENST0000055286406210_21327.3333333333333321908.0Compositional biasNote=Poly-Gln
TgeneLIN7Achr12:90003714chr12:81283148ENST0000055286406217_22927.3333333333333321908.0Compositional biasNote=Poly-Gln
TgeneLIN7Achr12:90003714chr12:81283148ENST0000055286406108_19027.3333333333333321908.0DomainPDZ
TgeneLIN7Achr12:90003714chr12:81283148ENST000005528640625_8027.3333333333333321908.0DomainL27

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-14201100_1117814.01221.0RegionCalmodulin-binding subdomain A
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-14201118_1220814.01221.0RegionRequired for basolateral membrane targeting
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-14191100_1117814.01185.0RegionCalmodulin-binding subdomain A
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-14191118_1220814.01185.0RegionRequired for basolateral membrane targeting
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-14211100_1117814.01177.0RegionCalmodulin-binding subdomain A
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-14211118_1220814.01177.0RegionRequired for basolateral membrane targeting
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-15211100_1117814.01221.0RegionCalmodulin-binding subdomain A
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-15211118_1220814.01221.0RegionRequired for basolateral membrane targeting
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-14201028_1039814.01221.0Topological domainExtracellular
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-14201061_1220814.01221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-1420440_855814.01221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-1420877_882814.01221.0Topological domainExtracellular
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-1420904_927814.01221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-1420949_971814.01221.0Topological domainExtracellular
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-1420992_1005814.01221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-14191028_1039814.01185.0Topological domainExtracellular
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-14191061_1220814.01185.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-1419440_855814.01185.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-1419877_882814.01185.0Topological domainExtracellular
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-1419904_927814.01185.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-1419949_971814.01185.0Topological domainExtracellular
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-1419992_1005814.01185.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-14211028_1039814.01177.0Topological domainExtracellular
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-14211061_1220814.01177.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-1421440_855814.01177.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-1421877_882814.01177.0Topological domainExtracellular
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-1421904_927814.01177.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-1421949_971814.01177.0Topological domainExtracellular
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-1421992_1005814.01177.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-15211028_1039814.01221.0Topological domainExtracellular
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-15211061_1220814.01221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-1521440_855814.01221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-1521877_882814.01221.0Topological domainExtracellular
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-1521904_927814.01221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-1521949_971814.01221.0Topological domainExtracellular
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-1521992_1005814.01221.0Topological domainCytoplasmic
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-14201006_1027814.01221.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-14201040_1060814.01221.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-1420856_876814.01221.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-1420883_903814.01221.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-1420928_948814.01221.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000261173-1420972_991814.01221.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-14191006_1027814.01185.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-14191040_1060814.01185.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-1419856_876814.01185.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-1419883_903814.01185.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-1419928_948814.01185.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000348959-1419972_991814.01185.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-14211006_1027814.01177.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-14211040_1060814.01177.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-1421856_876814.01177.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-1421883_903814.01177.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-1421928_948814.01177.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000359142-1421972_991814.01177.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-15211006_1027814.01221.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-15211040_1060814.01221.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-1521856_876814.01221.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-1521883_903814.01221.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-1521928_948814.01221.0TransmembraneHelical
HgeneATP2B1chr12:90003714chr12:81283148ENST00000428670-1521972_991814.01221.0TransmembraneHelical
TgeneLIN7Achr12:90003714chr12:81283148ENST000005528640614_2827.3333333333333321908.0MotifNote=Kinase interacting site


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ATP2B1
LIN7A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ATP2B1-LIN7A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ATP2B1-LIN7A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource