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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:RTN4-KIAA0196

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: RTN4-KIAA0196
	FusionPDB ID: 78575
	FusionGDB2.0 ID: 78575
		Hgene	Tgene
	Gene symbol	RTN4	KIAA0196
	Gene ID	57142	9897
	Gene name	reticulon 4	WASH complex subunit 5
	Synonyms	ASY\|NI220/250\|NOGO\|NSP\|NSP-CL\|Nbla00271\|Nbla10545\|RTN-X\|RTN4-A\|RTN4-B1\|RTN4-B2\|RTN4-C	KIAA0196\|RTSC\|RTSC1\|SPG8
	Cytomap	2p16.1	8q24.13
	Type of gene	protein-coding	protein-coding
	Description	reticulon-4Human NogoAMy043 proteinfoocenneurite growth inhibitor 220neurite outgrowth inhibitorneuroendocrine-specific protein C homologreticulon 5	WASH complex subunit 5WASH complex subunit strumpellinstrumpellin
	Modification date	20200327	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000317610, ENST00000337526, ENST00000354474, ENST00000357376, ENST00000357732, ENST00000394609, ENST00000394611, ENST00000402434, ENST00000404909, ENST00000405240, ENST00000486085,	ENST00000521109, ENST00000318410, ENST00000517845,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	18 X 22 X 7=2772	4 X 4 X 3=48
	# samples	27	5
	** MAII score	log2(27/2772*10)=-3.35989594508638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: RTN4 [Title/Abstract] AND KIAA0196 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	RTN4(55209650)-KIAA0196(126052140), # samples:1
Anticipated loss of major functional domain due to fusion event.	RTN4-KIAA0196 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RTN4-KIAA0196 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RTN4-KIAA0196 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RTN4-KIAA0196 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RTN4-KIAA0196 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. RTN4-KIAA0196 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. RTN4-KIAA0196 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RTN4	GO:0030517	negative regulation of axon extension	10667797
Hgene	RTN4	GO:0071787	endoplasmic reticulum tubular network formation	24262037\|25612671
Hgene	RTN4	GO:1905552	positive regulation of protein localization to endoplasmic reticulum	27353365

Fusion gene breakpoints across RTN4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KIAA0196 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-25-1313	RTN4	chr2	55209650	-	KIAA0196	chr8	126052140	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000394609	RTN4	chr2	55209650	-	ENST00000318410	KIAA0196	chr8	126052140	-	1697	710	329	1339	336
ENST00000394609	RTN4	chr2	55209650	-	ENST00000517845	KIAA0196	chr8	126052140	-	1690	710	329	1339	336
ENST00000317610	RTN4	chr2	55209650	-	ENST00000318410	KIAA0196	chr8	126052140	-	2134	1147	217	1776	519
ENST00000317610	RTN4	chr2	55209650	-	ENST00000517845	KIAA0196	chr8	126052140	-	2127	1147	217	1776	519
ENST00000357732	RTN4	chr2	55209650	-	ENST00000318410	KIAA0196	chr8	126052140	-	2191	1204	217	1833	538
ENST00000357732	RTN4	chr2	55209650	-	ENST00000517845	KIAA0196	chr8	126052140	-	2184	1204	217	1833	538
ENST00000337526	RTN4	chr2	55209650	-	ENST00000318410	KIAA0196	chr8	126052140	-	4591	3604	217	4233	1338
ENST00000337526	RTN4	chr2	55209650	-	ENST00000517845	KIAA0196	chr8	126052140	-	4584	3604	217	4233	1338
ENST00000354474	RTN4	chr2	55209650	-	ENST00000318410	KIAA0196	chr8	126052140	-	3651	2664	0	3293	1097
ENST00000354474	RTN4	chr2	55209650	-	ENST00000517845	KIAA0196	chr8	126052140	-	3644	2664	0	3293	1097
ENST00000402434	RTN4	chr2	55209650	-	ENST00000318410	KIAA0196	chr8	126052140	-	1882	895	49	1524	491
ENST00000402434	RTN4	chr2	55209650	-	ENST00000517845	KIAA0196	chr8	126052140	-	1875	895	49	1524	491

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000394609	ENST00000318410	RTN4	chr2	55209650	-	KIAA0196	chr8	126052140	-	0.000806808	0.99919325
ENST00000394609	ENST00000517845	RTN4	chr2	55209650	-	KIAA0196	chr8	126052140	-	0.000806479	0.9991935
ENST00000317610	ENST00000318410	RTN4	chr2	55209650	-	KIAA0196	chr8	126052140	-	0.001684717	0.99831533
ENST00000317610	ENST00000517845	RTN4	chr2	55209650	-	KIAA0196	chr8	126052140	-	0.00169068	0.9983094
ENST00000357732	ENST00000318410	RTN4	chr2	55209650	-	KIAA0196	chr8	126052140	-	0.001597913	0.99840206
ENST00000357732	ENST00000517845	RTN4	chr2	55209650	-	KIAA0196	chr8	126052140	-	0.001583957	0.99841607
ENST00000337526	ENST00000318410	RTN4	chr2	55209650	-	KIAA0196	chr8	126052140	-	0.000751657	0.9992483
ENST00000337526	ENST00000517845	RTN4	chr2	55209650	-	KIAA0196	chr8	126052140	-	0.000771728	0.99922824
ENST00000354474	ENST00000318410	RTN4	chr2	55209650	-	KIAA0196	chr8	126052140	-	0.000526251	0.99947375
ENST00000354474	ENST00000517845	RTN4	chr2	55209650	-	KIAA0196	chr8	126052140	-	0.000539892	0.99946016
ENST00000402434	ENST00000318410	RTN4	chr2	55209650	-	KIAA0196	chr8	126052140	-	0.001718134	0.99828184
ENST00000402434	ENST00000517845	RTN4	chr2	55209650	-	KIAA0196	chr8	126052140	-	0.001749196	0.9982508

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>78575_78575_1_RTN4-KIAA0196_RTN4_chr2_55209650_ENST00000317610_KIAA0196_chr8_126052140_ENST00000318410_length(amino acids)=519AA_BP=310
MQHHLHPPAMEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDF
GNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPS
TPAAPKRRGSSGSVVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESE
VAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKVGQMQILRQQIANELNYSCRFDSKHLAAALENLNKALLADIEAHYQDPSL
PYPKEDNTLLYEITAYLEAAGIHNPLNKIYITTKRLPYFPIVNFLFLIAQLPKLQYNKNLGMVCRKPTDPVDWPPLVLGLLTLLKQFHSR

--------------------------------------------------------------

>78575_78575_2_RTN4-KIAA0196_RTN4_chr2_55209650_ENST00000317610_KIAA0196_chr8_126052140_ENST00000517845_length(amino acids)=519AA_BP=310
MQHHLHPPAMEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDF
GNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPS
TPAAPKRRGSSGSVVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESE
VAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKVGQMQILRQQIANELNYSCRFDSKHLAAALENLNKALLADIEAHYQDPSL
PYPKEDNTLLYEITAYLEAAGIHNPLNKIYITTKRLPYFPIVNFLFLIAQLPKLQYNKNLGMVCRKPTDPVDWPPLVLGLLTLLKQFHSR

--------------------------------------------------------------

>78575_78575_3_RTN4-KIAA0196_RTN4_chr2_55209650_ENST00000337526_KIAA0196_chr8_126052140_ENST00000318410_length(amino acids)=1338AA_BP=1129
MQHHLHPPAMEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDF
GNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPS
TPAAPKRRGSSGSVDETLFALPAASEPVIRSSAENMDLKEQPGNTISAGQEDFPSVLLETAASLPSLSPLSAASFKEHEYLGNLSTVLPT
EGTLQENVSEASKEVSEKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAESAVIVANPREEIIVKNKDEEEKLVSNNILHNQQELPTALT
KLVKEDEVVSSEKAKDSFNEKRVAVEAPMREEYADFKPFERVWEVKDSKEDSDMLAAGGKIESNLESKVDKKCFADSLEQTNHEKDSESS
NDDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVT
TDNLTKVTEEVVANMPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLN
SAVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPENINAALQETEAPYISIACDLIKETKLSAEP
APDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKPYLE
SFKLSLDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSDSSPIEIIDEFPTLISSKTDSFSKLAREYTD
LEVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQPKVEEKISFSDDFSKNGSATSKVLLLPPDVSALATQAEIESIVKPKVLVKEAEKKL
PSDTEKEDRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGH
PFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKVGQMQILRQQIANELNYSCRFDSKHLAAALENLNKALLADI
EAHYQDPSLPYPKEDNTLLYEITAYLEAAGIHNPLNKIYITTKRLPYFPIVNFLFLIAQLPKLQYNKNLGMVCRKPTDPVDWPPLVLGLL

--------------------------------------------------------------

>78575_78575_4_RTN4-KIAA0196_RTN4_chr2_55209650_ENST00000337526_KIAA0196_chr8_126052140_ENST00000517845_length(amino acids)=1338AA_BP=1129
MQHHLHPPAMEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDF
GNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPS
TPAAPKRRGSSGSVDETLFALPAASEPVIRSSAENMDLKEQPGNTISAGQEDFPSVLLETAASLPSLSPLSAASFKEHEYLGNLSTVLPT
EGTLQENVSEASKEVSEKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAESAVIVANPREEIIVKNKDEEEKLVSNNILHNQQELPTALT
KLVKEDEVVSSEKAKDSFNEKRVAVEAPMREEYADFKPFERVWEVKDSKEDSDMLAAGGKIESNLESKVDKKCFADSLEQTNHEKDSESS
NDDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVT
TDNLTKVTEEVVANMPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLN
SAVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPENINAALQETEAPYISIACDLIKETKLSAEP
APDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKPYLE
SFKLSLDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSDSSPIEIIDEFPTLISSKTDSFSKLAREYTD
LEVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQPKVEEKISFSDDFSKNGSATSKVLLLPPDVSALATQAEIESIVKPKVLVKEAEKKL
PSDTEKEDRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGH
PFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKVGQMQILRQQIANELNYSCRFDSKHLAAALENLNKALLADI
EAHYQDPSLPYPKEDNTLLYEITAYLEAAGIHNPLNKIYITTKRLPYFPIVNFLFLIAQLPKLQYNKNLGMVCRKPTDPVDWPPLVLGLL

--------------------------------------------------------------

>78575_78575_5_RTN4-KIAA0196_RTN4_chr2_55209650_ENST00000354474_KIAA0196_chr8_126052140_ENST00000318410_length(amino acids)=1097AA_BP=888
MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKQFSELEYSEMGSSFSVSPKAESAVIVANPREE
IIVKNKDEEEKLVSNNILHNQQELPTALTKLVKEDEVVSSEKAKDSFNEKRVAVEAPMREEYADFKPFERVWEVKDSKEDSDMLAAGGKI
ESNLESKVDKKCFADSLEQTNHEKDSESSNDDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDEKKIEEKKA
QIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVVANMPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYP
AAQLCPSFEESEATPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPEN
INAALQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKESLT
ETSFESMIEYENKEKLSALPPEGGKPYLESFKLSLDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSDS
SPIEIIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQPKVEEKISFSDDFSKNGSATSKVLLLP
PDVSALATQAEIESIVKPKVLVKEAEKKLPSDTEKEDRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAY
IALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKVGQMQILRQQIA
NELNYSCRFDSKHLAAALENLNKALLADIEAHYQDPSLPYPKEDNTLLYEITAYLEAAGIHNPLNKIYITTKRLPYFPIVNFLFLIAQLP
KLQYNKNLGMVCRKPTDPVDWPPLVLGLLTLLKQFHSRYTEQFLALIGQFICSTVEQCTSQKIPEIPADVVGALLFLEDYVRYTKLPRRV

--------------------------------------------------------------

>78575_78575_6_RTN4-KIAA0196_RTN4_chr2_55209650_ENST00000354474_KIAA0196_chr8_126052140_ENST00000517845_length(amino acids)=1097AA_BP=888
MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKQFSELEYSEMGSSFSVSPKAESAVIVANPREE
IIVKNKDEEEKLVSNNILHNQQELPTALTKLVKEDEVVSSEKAKDSFNEKRVAVEAPMREEYADFKPFERVWEVKDSKEDSDMLAAGGKI
ESNLESKVDKKCFADSLEQTNHEKDSESSNDDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDEKKIEEKKA
QIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVVANMPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYP
AAQLCPSFEESEATPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPEN
INAALQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKESLT
ETSFESMIEYENKEKLSALPPEGGKPYLESFKLSLDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSDS
SPIEIIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQPKVEEKISFSDDFSKNGSATSKVLLLP
PDVSALATQAEIESIVKPKVLVKEAEKKLPSDTEKEDRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAY
IALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKVGQMQILRQQIA
NELNYSCRFDSKHLAAALENLNKALLADIEAHYQDPSLPYPKEDNTLLYEITAYLEAAGIHNPLNKIYITTKRLPYFPIVNFLFLIAQLP
KLQYNKNLGMVCRKPTDPVDWPPLVLGLLTLLKQFHSRYTEQFLALIGQFICSTVEQCTSQKIPEIPADVVGALLFLEDYVRYTKLPRRV

--------------------------------------------------------------

>78575_78575_7_RTN4-KIAA0196_RTN4_chr2_55209650_ENST00000357732_KIAA0196_chr8_126052140_ENST00000318410_length(amino acids)=538AA_BP=329
MQHHLHPPAMEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDF
GNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPS
TPAAPKRRGSSGSVDETLFALPAASEPVIRSSAVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVI
QAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKVGQMQILRQQIANELNYSCRFDSKHLAAALE
NLNKALLADIEAHYQDPSLPYPKEDNTLLYEITAYLEAAGIHNPLNKIYITTKRLPYFPIVNFLFLIAQLPKLQYNKNLGMVCRKPTDPV

--------------------------------------------------------------

>78575_78575_8_RTN4-KIAA0196_RTN4_chr2_55209650_ENST00000357732_KIAA0196_chr8_126052140_ENST00000517845_length(amino acids)=538AA_BP=329
MQHHLHPPAMEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDF
GNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPS
TPAAPKRRGSSGSVDETLFALPAASEPVIRSSAVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVI
QAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKVGQMQILRQQIANELNYSCRFDSKHLAAALE
NLNKALLADIEAHYQDPSLPYPKEDNTLLYEITAYLEAAGIHNPLNKIYITTKRLPYFPIVNFLFLIAQLPKLQYNKNLGMVCRKPTDPV

--------------------------------------------------------------

>78575_78575_9_RTN4-KIAA0196_RTN4_chr2_55209650_ENST00000394609_KIAA0196_chr8_126052140_ENST00000318410_length(amino acids)=336AA_BP=127
MDGQKKNWKDKVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAI
SEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKVGQMQILRQQIANELNYSCRFDSKHLAAALENLNKALLADIEAHYQDPSLPYP
KEDNTLLYEITAYLEAAGIHNPLNKIYITTKRLPYFPIVNFLFLIAQLPKLQYNKNLGMVCRKPTDPVDWPPLVLGLLTLLKQFHSRYTE

--------------------------------------------------------------

>78575_78575_10_RTN4-KIAA0196_RTN4_chr2_55209650_ENST00000394609_KIAA0196_chr8_126052140_ENST00000517845_length(amino acids)=336AA_BP=127
MDGQKKNWKDKVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAI
SEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKVGQMQILRQQIANELNYSCRFDSKHLAAALENLNKALLADIEAHYQDPSLPYP
KEDNTLLYEITAYLEAAGIHNPLNKIYITTKRLPYFPIVNFLFLIAQLPKLQYNKNLGMVCRKPTDPVDWPPLVLGLLTLLKQFHSRYTE

--------------------------------------------------------------

>78575_78575_11_RTN4-KIAA0196_RTN4_chr2_55209650_ENST00000402434_KIAA0196_chr8_126052140_ENST00000318410_length(amino acids)=491AA_BP=282
MQHHLHPPAMEPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWD
PSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRGSSGSVVVDLLYWRDIKKTG
VVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRR
LFLVDDLVDSLKVGQMQILRQQIANELNYSCRFDSKHLAAALENLNKALLADIEAHYQDPSLPYPKEDNTLLYEITAYLEAAGIHNPLNK
IYITTKRLPYFPIVNFLFLIAQLPKLQYNKNLGMVCRKPTDPVDWPPLVLGLLTLLKQFHSRYTEQFLALIGQFICSTVEQCTSQKIPEI

--------------------------------------------------------------

>78575_78575_12_RTN4-KIAA0196_RTN4_chr2_55209650_ENST00000402434_KIAA0196_chr8_126052140_ENST00000517845_length(amino acids)=491AA_BP=282
MQHHLHPPAMEPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWD
PSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRGSSGSVVVDLLYWRDIKKTG
VVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRR
LFLVDDLVDSLKVGQMQILRQQIANELNYSCRFDSKHLAAALENLNKALLADIEAHYQDPSLPYPKEDNTLLYEITAYLEAAGIHNPLNK
IYITTKRLPYFPIVNFLFLIAQLPKLQYNKNLGMVCRKPTDPVDWPPLVLGLLTLLKQFHSRYTEQFLALIGQFICSTVEQCTSQKIPEI

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:55209650/chr8:126052140)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000317610

143_148

301.0

374.0

Compositional bias

Note=Poly-Pro

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000317610

30_47

301.0

374.0

Compositional bias

Note=Poly-Glu

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000337526

143_148

1120.0

1193.0

Compositional bias

Note=Poly-Pro

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000337526

30_47

1120.0

1193.0

Compositional bias

Note=Poly-Glu

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000357376

143_148

914.0

987.0

Compositional bias

Note=Poly-Pro

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000357376

30_47

914.0

987.0

Compositional bias

Note=Poly-Glu

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000357732

143_148

320.0

393.0

Compositional bias

Note=Poly-Pro

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000357732

30_47

320.0

393.0

Compositional bias

Note=Poly-Glu

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000394609

30_47

127.0

200.0

Compositional bias

Note=Poly-Glu

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000394611

143_148

914.0

987.0

Compositional bias

Note=Poly-Pro

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000394611

30_47

914.0

987.0

Compositional bias

Note=Poly-Glu

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000404909

143_148

914.0

987.0

Compositional bias

Note=Poly-Pro

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000404909

30_47

914.0

987.0

Compositional bias

Note=Poly-Glu

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000405240

143_148

914.0

987.0

Compositional bias

Note=Poly-Pro

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000405240

30_47

914.0

987.0

Compositional bias

Note=Poly-Glu

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000337526

1_1018

1120.0

1193.0

Topological domain

Cytoplasmic

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000337526

1019_1039

1120.0

1193.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000394609

143_148

127.0

200.0

Compositional bias

Note=Poly-Pro

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000317610

1005_1192

301.0

374.0

Domain

Reticulon

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000337526

1005_1192

1120.0

1193.0

Domain

Reticulon

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000357376

1005_1192

914.0

987.0

Domain

Reticulon

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000357732

1005_1192

320.0

393.0

Domain

Reticulon

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000394609

1005_1192

127.0

200.0

Domain

Reticulon

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000394611

1005_1192

914.0

987.0

Domain

Reticulon

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000404909

1005_1192

914.0

987.0

Domain

Reticulon

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000405240

1005_1192

914.0

987.0

Domain

Reticulon

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000317610

1040_1133

301.0

374.0

Topological domain

Lumenal

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000317610

1155_1192

301.0

374.0

Topological domain

Cytoplasmic

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000317610

1_1018

301.0

374.0

Topological domain

Cytoplasmic

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000337526

1040_1133

1120.0

1193.0

Topological domain

Lumenal

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000337526

1155_1192

1120.0

1193.0

Topological domain

Cytoplasmic

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000357376

1040_1133

914.0

987.0

Topological domain

Lumenal

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000357376

1155_1192

914.0

987.0

Topological domain

Cytoplasmic

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000357376

1_1018

914.0

987.0

Topological domain

Cytoplasmic

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000357732

1040_1133

320.0

393.0

Topological domain

Lumenal

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000357732

1155_1192

320.0

393.0

Topological domain

Cytoplasmic

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000357732

1_1018

320.0

393.0

Topological domain

Cytoplasmic

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000394609

1040_1133

127.0

200.0

Topological domain

Lumenal

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000394609

1155_1192

127.0

200.0

Topological domain

Cytoplasmic

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000394609

1_1018

127.0

200.0

Topological domain

Cytoplasmic

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000394611

1040_1133

914.0

987.0

Topological domain

Lumenal

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000394611

1155_1192

914.0

987.0

Topological domain

Cytoplasmic

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000394611

1_1018

914.0

987.0

Topological domain

Cytoplasmic

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000404909

1040_1133

914.0

987.0

Topological domain

Lumenal

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000404909

1155_1192

914.0

987.0

Topological domain

Cytoplasmic

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000404909

1_1018

914.0

987.0

Topological domain

Cytoplasmic

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000405240

1040_1133

914.0

987.0

Topological domain

Lumenal

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000405240

1155_1192

914.0

987.0

Topological domain

Cytoplasmic

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000405240

1_1018

914.0

987.0

Topological domain

Cytoplasmic

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000317610

1019_1039

301.0

374.0

Transmembrane

Helical

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000317610

1134_1154

301.0

374.0

Transmembrane

Helical

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000337526

1134_1154

1120.0

1193.0

Transmembrane

Helical

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000357376

1019_1039

914.0

987.0

Transmembrane

Helical

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000357376

1134_1154

914.0

987.0

Transmembrane

Helical

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000357732

1019_1039

320.0

393.0

Transmembrane

Helical

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000357732

1134_1154

320.0

393.0

Transmembrane

Helical

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000394609

1019_1039

127.0

200.0

Transmembrane

Helical

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000394609

1134_1154

127.0

200.0

Transmembrane

Helical

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000394611

1019_1039

914.0

987.0

Transmembrane

Helical

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000394611

1134_1154

914.0

987.0

Transmembrane

Helical

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000404909

1019_1039

914.0

987.0

Transmembrane

Helical

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000404909

1134_1154

914.0

987.0

Transmembrane

Helical

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000405240

1019_1039

914.0

987.0

Transmembrane

Helical

Hgene

RTN4

chr2:55209650

chr8:126052140

ENST00000405240

1134_1154

914.0

987.0

Transmembrane

Helical

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
RTN4
KIAA0196

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to RTN4-KIAA0196

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to RTN4-KIAA0196

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source