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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ATP2C1-FAIM

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ATP2C1-FAIM
FusionPDB ID: 7886
FusionGDB2.0 ID: 7886
HgeneTgene
Gene symbol

ATP2C1

FAIM

Gene ID

27032

55179

Gene nameATPase secretory pathway Ca2+ transporting 1Fas apoptotic inhibitory molecule
SynonymsATP2C1A|BCPM|HHD|PMR1|SPCA1|hSPCA1FAIM1
Cytomap

3q22.1

3q22.3

Type of geneprotein-codingprotein-coding
Descriptioncalcium-transporting ATPase type 2C member 1ATP-dependent Ca(2+) pump PMR1ATPase 2C1ATPase, Ca(2+)-sequesteringATPase, Ca++ transporting, type 2C, member 1HUSSY-28secretory pathway Ca2+/Mn2+ ATPase 1fas apoptotic inhibitory molecule 1
Modification date2020031320200313
UniProtAcc

P98194

Q9BWQ8

Ensembl transtripts involved in fusion geneENST idsENST00000359644, ENST00000393221, 
ENST00000422190, ENST00000428331, 
ENST00000504381, ENST00000504948, 
ENST00000505330, ENST00000507488, 
ENST00000508532, ENST00000510168, 
ENST00000513801, ENST00000533801, 
ENST00000328560, ENST00000509150, 
ENST00000393034, ENST00000393035, 
ENST00000464668, ENST00000338446, 
ENST00000360570, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 17 X 10=27204 X 3 X 4=48
# samples 194
** MAII scorelog2(19/2720*10)=-3.83953532780675
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ATP2C1 [Title/Abstract] AND FAIM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ATP2C1(130720158)-FAIM(138340249), # samples:1
Anticipated loss of major functional domain due to fusion event.ATP2C1-FAIM seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ATP2C1-FAIM seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ATP2C1-FAIM seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATP2C1

GO:0006816

calcium ion transport

12810057

HgeneATP2C1

GO:0006874

cellular calcium ion homeostasis

12810057


check buttonFusion gene breakpoints across ATP2C1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAIM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4HB-01AATP2C1chr3

130720158

+FAIMchr3

138340249

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000510168ATP2C1chr3130720158+ENST00000338446FAIMchr3138340249+583149725503183877
ENST00000510168ATP2C1chr3130720158+ENST00000360570FAIMchr3138340249+583149725503183877

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000510168ENST00000338446ATP2C1chr3130720158+FAIMchr3138340249+0.0003471450.99965286
ENST00000510168ENST00000360570ATP2C1chr3130720158+FAIMchr3138340249+0.0003471450.99965286

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>7886_7886_1_ATP2C1-FAIM_ATP2C1_chr3_130720158_ENST00000510168_FAIM_chr3_138340249_ENST00000338446_length(amino acids)=877AA_BP=
MKVARFQKIPNGENETMIPVLTSKKASELPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLAS
AVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVD
LSIDESSLTGETTPCSKVTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLS
FYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEM
TVTHIFTSDGLHAEVTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKA
EYPFSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLG
LVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIK
SLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLA
TLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTM

--------------------------------------------------------------

>7886_7886_2_ATP2C1-FAIM_ATP2C1_chr3_130720158_ENST00000510168_FAIM_chr3_138340249_ENST00000360570_length(amino acids)=877AA_BP=
MKVARFQKIPNGENETMIPVLTSKKASELPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLAS
AVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVD
LSIDESSLTGETTPCSKVTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLS
FYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEM
TVTHIFTSDGLHAEVTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKA
EYPFSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLG
LVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIK
SLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLA
TLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTM

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:130720158/chr3:138340249)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP2C1

P98194

FAIM

Q9BWQ8

FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.FUNCTION: Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. {ECO:0000269|PubMed:10535980, ECO:0000269|PubMed:17635665}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP2C1chr3:130720158chr3:138340249ENST00000393221+2728124_262942.0974.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000393221+27281_70942.0974.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000393221+2728283_294942.0974.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000393221+2728313_699942.0974.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000393221+2728720_729942.0974.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000393221+2728751_770942.0974.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000393221+2728794_808942.0974.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000393221+2728829_841942.0974.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000393221+2728861_875942.0974.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000393221+2728897_919942.0974.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000393221+272892_104942.0974.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000422190+2728124_262908.0940.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000422190+27281_70908.0940.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000422190+2728283_294908.0940.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000422190+2728313_699908.0940.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000422190+2728720_729908.0940.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000422190+2728751_770908.0940.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000422190+2728794_808908.0940.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000422190+2728829_841908.0940.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000422190+2728861_875908.0940.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000422190+272892_104908.0940.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000507488+2728124_262892.0924.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000507488+27281_70892.0924.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000507488+2728283_294892.0924.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000507488+2728313_699892.0924.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000507488+2728720_729892.0924.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000507488+2728751_770892.0924.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000507488+2728794_808892.0924.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000507488+2728829_841892.0924.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000507488+2728861_875892.0924.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000507488+272892_104892.0924.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000513801+2728124_262892.0924.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000513801+27281_70892.0924.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000513801+2728283_294892.0924.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000513801+2728313_699892.0924.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000513801+2728720_729892.0924.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000513801+2728751_770892.0924.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000513801+2728794_808892.0924.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000513801+2728829_841892.0924.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000513801+2728861_875892.0924.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000513801+272892_104892.0924.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000393221+2728105_123942.0974.0TransmembraneHelical%3B Name%3D2
HgeneATP2C1chr3:130720158chr3:138340249ENST00000393221+2728263_282942.0974.0TransmembraneHelical%3B Name%3D3
HgeneATP2C1chr3:130720158chr3:138340249ENST00000393221+2728295_312942.0974.0TransmembraneHelical%3B Name%3D4
HgeneATP2C1chr3:130720158chr3:138340249ENST00000393221+2728700_719942.0974.0TransmembraneHelical%3B Name%3D5
HgeneATP2C1chr3:130720158chr3:138340249ENST00000393221+272871_91942.0974.0TransmembraneHelical%3B Name%3D1
HgeneATP2C1chr3:130720158chr3:138340249ENST00000393221+2728730_750942.0974.0TransmembraneHelical%3B Name%3D6
HgeneATP2C1chr3:130720158chr3:138340249ENST00000393221+2728771_793942.0974.0TransmembraneHelical%3B Name%3D7
HgeneATP2C1chr3:130720158chr3:138340249ENST00000393221+2728809_828942.0974.0TransmembraneHelical%3B Name%3D8
HgeneATP2C1chr3:130720158chr3:138340249ENST00000393221+2728842_860942.0974.0TransmembraneHelical%3B Name%3D9
HgeneATP2C1chr3:130720158chr3:138340249ENST00000393221+2728876_896942.0974.0TransmembraneHelical%3B Name%3D10
HgeneATP2C1chr3:130720158chr3:138340249ENST00000422190+2728105_123908.0940.0TransmembraneHelical%3B Name%3D2
HgeneATP2C1chr3:130720158chr3:138340249ENST00000422190+2728263_282908.0940.0TransmembraneHelical%3B Name%3D3
HgeneATP2C1chr3:130720158chr3:138340249ENST00000422190+2728295_312908.0940.0TransmembraneHelical%3B Name%3D4
HgeneATP2C1chr3:130720158chr3:138340249ENST00000422190+2728700_719908.0940.0TransmembraneHelical%3B Name%3D5
HgeneATP2C1chr3:130720158chr3:138340249ENST00000422190+272871_91908.0940.0TransmembraneHelical%3B Name%3D1
HgeneATP2C1chr3:130720158chr3:138340249ENST00000422190+2728730_750908.0940.0TransmembraneHelical%3B Name%3D6
HgeneATP2C1chr3:130720158chr3:138340249ENST00000422190+2728771_793908.0940.0TransmembraneHelical%3B Name%3D7
HgeneATP2C1chr3:130720158chr3:138340249ENST00000422190+2728809_828908.0940.0TransmembraneHelical%3B Name%3D8
HgeneATP2C1chr3:130720158chr3:138340249ENST00000422190+2728842_860908.0940.0TransmembraneHelical%3B Name%3D9
HgeneATP2C1chr3:130720158chr3:138340249ENST00000422190+2728876_896908.0940.0TransmembraneHelical%3B Name%3D10
HgeneATP2C1chr3:130720158chr3:138340249ENST00000507488+2728105_123892.0924.0TransmembraneHelical%3B Name%3D2
HgeneATP2C1chr3:130720158chr3:138340249ENST00000507488+2728263_282892.0924.0TransmembraneHelical%3B Name%3D3
HgeneATP2C1chr3:130720158chr3:138340249ENST00000507488+2728295_312892.0924.0TransmembraneHelical%3B Name%3D4
HgeneATP2C1chr3:130720158chr3:138340249ENST00000507488+2728700_719892.0924.0TransmembraneHelical%3B Name%3D5
HgeneATP2C1chr3:130720158chr3:138340249ENST00000507488+272871_91892.0924.0TransmembraneHelical%3B Name%3D1
HgeneATP2C1chr3:130720158chr3:138340249ENST00000507488+2728730_750892.0924.0TransmembraneHelical%3B Name%3D6
HgeneATP2C1chr3:130720158chr3:138340249ENST00000507488+2728771_793892.0924.0TransmembraneHelical%3B Name%3D7
HgeneATP2C1chr3:130720158chr3:138340249ENST00000507488+2728809_828892.0924.0TransmembraneHelical%3B Name%3D8
HgeneATP2C1chr3:130720158chr3:138340249ENST00000507488+2728842_860892.0924.0TransmembraneHelical%3B Name%3D9
HgeneATP2C1chr3:130720158chr3:138340249ENST00000513801+2728105_123892.0924.0TransmembraneHelical%3B Name%3D2
HgeneATP2C1chr3:130720158chr3:138340249ENST00000513801+2728263_282892.0924.0TransmembraneHelical%3B Name%3D3
HgeneATP2C1chr3:130720158chr3:138340249ENST00000513801+2728295_312892.0924.0TransmembraneHelical%3B Name%3D4
HgeneATP2C1chr3:130720158chr3:138340249ENST00000513801+2728700_719892.0924.0TransmembraneHelical%3B Name%3D5
HgeneATP2C1chr3:130720158chr3:138340249ENST00000513801+272871_91892.0924.0TransmembraneHelical%3B Name%3D1
HgeneATP2C1chr3:130720158chr3:138340249ENST00000513801+2728730_750892.0924.0TransmembraneHelical%3B Name%3D6
HgeneATP2C1chr3:130720158chr3:138340249ENST00000513801+2728771_793892.0924.0TransmembraneHelical%3B Name%3D7
HgeneATP2C1chr3:130720158chr3:138340249ENST00000513801+2728809_828892.0924.0TransmembraneHelical%3B Name%3D8
HgeneATP2C1chr3:130720158chr3:138340249ENST00000513801+2728842_860892.0924.0TransmembraneHelical%3B Name%3D9

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP2C1chr3:130720158chr3:138340249ENST00000328560+127124_2620889.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000328560+1271_700889.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000328560+127283_2940889.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000328560+127313_6990889.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000328560+127720_7290889.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000328560+127751_7700889.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000328560+127794_8080889.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000328560+127829_8410889.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000328560+127861_8750889.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000328560+127897_9190889.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000328560+12792_1040889.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000359644+128124_2620950.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000359644+1281_700950.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000359644+128283_2940950.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000359644+128313_6990950.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000359644+128720_7290950.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000359644+128751_7700950.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000359644+128794_8080950.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000359644+128829_8410950.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000359644+128861_8750950.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000359644+128897_9190950.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000359644+12892_1040950.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000422190+2728897_919908.0940.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000428331+127124_2620920.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000428331+1271_700920.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000428331+127283_2940920.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000428331+127313_6990920.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000428331+127720_7290920.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000428331+127751_7700920.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000428331+127794_8080920.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000428331+127829_8410920.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000428331+127861_8750920.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000428331+127897_9190920.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000428331+12792_1040920.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000504948+127124_2620904.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000504948+1271_700904.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000504948+127283_2940904.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000504948+127313_6990904.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000504948+127720_7290904.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000504948+127751_7700904.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000504948+127794_8080904.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000504948+127829_8410904.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000504948+127861_8750904.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000504948+127897_9190904.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000504948+12792_1040904.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000505330+127124_2620904.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000505330+1271_700904.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000505330+127283_2940904.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000505330+127313_6990904.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000505330+127720_7290904.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000505330+127751_7700904.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000505330+127794_8080904.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000505330+127829_8410904.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000505330+127861_8750904.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000505330+127897_9190904.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000505330+12792_1040904.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000507488+2728897_919892.0924.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000508532+128124_2620920.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000508532+1281_700920.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000508532+128283_2940920.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000508532+128313_6990920.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000508532+128720_7290920.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000508532+128751_7700920.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000508532+128794_8080920.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000508532+128829_8410920.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000508532+128861_8750920.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000508532+128897_9190920.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000508532+12892_1040920.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000510168+128124_2620920.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000510168+1281_700920.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000510168+128283_2940920.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000510168+128313_6990920.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000510168+128720_7290920.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000510168+128751_7700920.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000510168+128794_8080920.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000510168+128829_8410920.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000510168+128861_8750920.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000510168+128897_9190920.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000510168+12892_1040920.0Topological domainLumenal
HgeneATP2C1chr3:130720158chr3:138340249ENST00000513801+2728897_919892.0924.0Topological domainCytoplasmic
HgeneATP2C1chr3:130720158chr3:138340249ENST00000328560+127105_1230889.0TransmembraneHelical%3B Name%3D2
HgeneATP2C1chr3:130720158chr3:138340249ENST00000328560+127263_2820889.0TransmembraneHelical%3B Name%3D3
HgeneATP2C1chr3:130720158chr3:138340249ENST00000328560+127295_3120889.0TransmembraneHelical%3B Name%3D4
HgeneATP2C1chr3:130720158chr3:138340249ENST00000328560+127700_7190889.0TransmembraneHelical%3B Name%3D5
HgeneATP2C1chr3:130720158chr3:138340249ENST00000328560+12771_910889.0TransmembraneHelical%3B Name%3D1
HgeneATP2C1chr3:130720158chr3:138340249ENST00000328560+127730_7500889.0TransmembraneHelical%3B Name%3D6
HgeneATP2C1chr3:130720158chr3:138340249ENST00000328560+127771_7930889.0TransmembraneHelical%3B Name%3D7
HgeneATP2C1chr3:130720158chr3:138340249ENST00000328560+127809_8280889.0TransmembraneHelical%3B Name%3D8
HgeneATP2C1chr3:130720158chr3:138340249ENST00000328560+127842_8600889.0TransmembraneHelical%3B Name%3D9
HgeneATP2C1chr3:130720158chr3:138340249ENST00000328560+127876_8960889.0TransmembraneHelical%3B Name%3D10
HgeneATP2C1chr3:130720158chr3:138340249ENST00000359644+128105_1230950.0TransmembraneHelical%3B Name%3D2
HgeneATP2C1chr3:130720158chr3:138340249ENST00000359644+128263_2820950.0TransmembraneHelical%3B Name%3D3
HgeneATP2C1chr3:130720158chr3:138340249ENST00000359644+128295_3120950.0TransmembraneHelical%3B Name%3D4
HgeneATP2C1chr3:130720158chr3:138340249ENST00000359644+128700_7190950.0TransmembraneHelical%3B Name%3D5
HgeneATP2C1chr3:130720158chr3:138340249ENST00000359644+12871_910950.0TransmembraneHelical%3B Name%3D1
HgeneATP2C1chr3:130720158chr3:138340249ENST00000359644+128730_7500950.0TransmembraneHelical%3B Name%3D6
HgeneATP2C1chr3:130720158chr3:138340249ENST00000359644+128771_7930950.0TransmembraneHelical%3B Name%3D7
HgeneATP2C1chr3:130720158chr3:138340249ENST00000359644+128809_8280950.0TransmembraneHelical%3B Name%3D8
HgeneATP2C1chr3:130720158chr3:138340249ENST00000359644+128842_8600950.0TransmembraneHelical%3B Name%3D9
HgeneATP2C1chr3:130720158chr3:138340249ENST00000359644+128876_8960950.0TransmembraneHelical%3B Name%3D10
HgeneATP2C1chr3:130720158chr3:138340249ENST00000428331+127105_1230920.0TransmembraneHelical%3B Name%3D2
HgeneATP2C1chr3:130720158chr3:138340249ENST00000428331+127263_2820920.0TransmembraneHelical%3B Name%3D3
HgeneATP2C1chr3:130720158chr3:138340249ENST00000428331+127295_3120920.0TransmembraneHelical%3B Name%3D4
HgeneATP2C1chr3:130720158chr3:138340249ENST00000428331+127700_7190920.0TransmembraneHelical%3B Name%3D5
HgeneATP2C1chr3:130720158chr3:138340249ENST00000428331+12771_910920.0TransmembraneHelical%3B Name%3D1
HgeneATP2C1chr3:130720158chr3:138340249ENST00000428331+127730_7500920.0TransmembraneHelical%3B Name%3D6
HgeneATP2C1chr3:130720158chr3:138340249ENST00000428331+127771_7930920.0TransmembraneHelical%3B Name%3D7
HgeneATP2C1chr3:130720158chr3:138340249ENST00000428331+127809_8280920.0TransmembraneHelical%3B Name%3D8
HgeneATP2C1chr3:130720158chr3:138340249ENST00000428331+127842_8600920.0TransmembraneHelical%3B Name%3D9
HgeneATP2C1chr3:130720158chr3:138340249ENST00000428331+127876_8960920.0TransmembraneHelical%3B Name%3D10
HgeneATP2C1chr3:130720158chr3:138340249ENST00000504948+127105_1230904.0TransmembraneHelical%3B Name%3D2
HgeneATP2C1chr3:130720158chr3:138340249ENST00000504948+127263_2820904.0TransmembraneHelical%3B Name%3D3
HgeneATP2C1chr3:130720158chr3:138340249ENST00000504948+127295_3120904.0TransmembraneHelical%3B Name%3D4
HgeneATP2C1chr3:130720158chr3:138340249ENST00000504948+127700_7190904.0TransmembraneHelical%3B Name%3D5
HgeneATP2C1chr3:130720158chr3:138340249ENST00000504948+12771_910904.0TransmembraneHelical%3B Name%3D1
HgeneATP2C1chr3:130720158chr3:138340249ENST00000504948+127730_7500904.0TransmembraneHelical%3B Name%3D6
HgeneATP2C1chr3:130720158chr3:138340249ENST00000504948+127771_7930904.0TransmembraneHelical%3B Name%3D7
HgeneATP2C1chr3:130720158chr3:138340249ENST00000504948+127809_8280904.0TransmembraneHelical%3B Name%3D8
HgeneATP2C1chr3:130720158chr3:138340249ENST00000504948+127842_8600904.0TransmembraneHelical%3B Name%3D9
HgeneATP2C1chr3:130720158chr3:138340249ENST00000504948+127876_8960904.0TransmembraneHelical%3B Name%3D10
HgeneATP2C1chr3:130720158chr3:138340249ENST00000505330+127105_1230904.0TransmembraneHelical%3B Name%3D2
HgeneATP2C1chr3:130720158chr3:138340249ENST00000505330+127263_2820904.0TransmembraneHelical%3B Name%3D3
HgeneATP2C1chr3:130720158chr3:138340249ENST00000505330+127295_3120904.0TransmembraneHelical%3B Name%3D4
HgeneATP2C1chr3:130720158chr3:138340249ENST00000505330+127700_7190904.0TransmembraneHelical%3B Name%3D5
HgeneATP2C1chr3:130720158chr3:138340249ENST00000505330+12771_910904.0TransmembraneHelical%3B Name%3D1
HgeneATP2C1chr3:130720158chr3:138340249ENST00000505330+127730_7500904.0TransmembraneHelical%3B Name%3D6
HgeneATP2C1chr3:130720158chr3:138340249ENST00000505330+127771_7930904.0TransmembraneHelical%3B Name%3D7
HgeneATP2C1chr3:130720158chr3:138340249ENST00000505330+127809_8280904.0TransmembraneHelical%3B Name%3D8
HgeneATP2C1chr3:130720158chr3:138340249ENST00000505330+127842_8600904.0TransmembraneHelical%3B Name%3D9
HgeneATP2C1chr3:130720158chr3:138340249ENST00000505330+127876_8960904.0TransmembraneHelical%3B Name%3D10
HgeneATP2C1chr3:130720158chr3:138340249ENST00000507488+2728876_896892.0924.0TransmembraneHelical%3B Name%3D10
HgeneATP2C1chr3:130720158chr3:138340249ENST00000508532+128105_1230920.0TransmembraneHelical%3B Name%3D2
HgeneATP2C1chr3:130720158chr3:138340249ENST00000508532+128263_2820920.0TransmembraneHelical%3B Name%3D3
HgeneATP2C1chr3:130720158chr3:138340249ENST00000508532+128295_3120920.0TransmembraneHelical%3B Name%3D4
HgeneATP2C1chr3:130720158chr3:138340249ENST00000508532+128700_7190920.0TransmembraneHelical%3B Name%3D5
HgeneATP2C1chr3:130720158chr3:138340249ENST00000508532+12871_910920.0TransmembraneHelical%3B Name%3D1
HgeneATP2C1chr3:130720158chr3:138340249ENST00000508532+128730_7500920.0TransmembraneHelical%3B Name%3D6
HgeneATP2C1chr3:130720158chr3:138340249ENST00000508532+128771_7930920.0TransmembraneHelical%3B Name%3D7
HgeneATP2C1chr3:130720158chr3:138340249ENST00000508532+128809_8280920.0TransmembraneHelical%3B Name%3D8
HgeneATP2C1chr3:130720158chr3:138340249ENST00000508532+128842_8600920.0TransmembraneHelical%3B Name%3D9
HgeneATP2C1chr3:130720158chr3:138340249ENST00000508532+128876_8960920.0TransmembraneHelical%3B Name%3D10
HgeneATP2C1chr3:130720158chr3:138340249ENST00000510168+128105_1230920.0TransmembraneHelical%3B Name%3D2
HgeneATP2C1chr3:130720158chr3:138340249ENST00000510168+128263_2820920.0TransmembraneHelical%3B Name%3D3
HgeneATP2C1chr3:130720158chr3:138340249ENST00000510168+128295_3120920.0TransmembraneHelical%3B Name%3D4
HgeneATP2C1chr3:130720158chr3:138340249ENST00000510168+128700_7190920.0TransmembraneHelical%3B Name%3D5
HgeneATP2C1chr3:130720158chr3:138340249ENST00000510168+12871_910920.0TransmembraneHelical%3B Name%3D1
HgeneATP2C1chr3:130720158chr3:138340249ENST00000510168+128730_7500920.0TransmembraneHelical%3B Name%3D6
HgeneATP2C1chr3:130720158chr3:138340249ENST00000510168+128771_7930920.0TransmembraneHelical%3B Name%3D7
HgeneATP2C1chr3:130720158chr3:138340249ENST00000510168+128809_8280920.0TransmembraneHelical%3B Name%3D8
HgeneATP2C1chr3:130720158chr3:138340249ENST00000510168+128842_8600920.0TransmembraneHelical%3B Name%3D9
HgeneATP2C1chr3:130720158chr3:138340249ENST00000510168+128876_8960920.0TransmembraneHelical%3B Name%3D10
HgeneATP2C1chr3:130720158chr3:138340249ENST00000513801+2728876_896892.0924.0TransmembraneHelical%3B Name%3D10


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ATP2C1
FAIM


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ATP2C1-FAIM


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ATP2C1-FAIM


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource