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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:SAE1-BAX

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SAE1-BAX
	FusionPDB ID: 79005
	FusionGDB2.0 ID: 79005
		Hgene	Tgene
	Gene symbol	SAE1	BAX
	Gene ID	10055	581
	Gene name	SUMO1 activating enzyme subunit 1	BCL2 associated X, apoptosis regulator
	Synonyms	AOS1\|HSPC140\|SUA1\|UBLE1A	BCL2L4
	Cytomap	19q13.32	19q13.33
	Type of gene	protein-coding	protein-coding
	Description	SUMO-activating enzyme subunit 1SUMO-1 activating enzyme E1 N subunitSUMO-1 activating enzyme subunit 1activator of SUMO1sentrin/SUMO-activating protein AOS1ubiquitin-like 1-activating enzyme E1Aubiquitin-like protein SUMO-1 activating enzyme	apoptosis regulator BAXBCL2 associated X proteinBCL2-associated X protein omegaBaxdelta2G9Baxdelta2G9omegaBaxdelta2omegabcl-2-like protein 4bcl2-L-4
	Modification date	20200313	20200322
	UniProtAcc	.	TMBIM6
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000270225, ENST00000392776, ENST00000413379, ENST00000598840, ENST00000540850,	ENST00000293288, ENST00000354470, ENST00000391871, ENST00000415969, ENST00000345358, ENST00000539787,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	17 X 10 X 12=2040	4 X 3 X 3=36
	# samples	19	6
	** MAII score	log2(19/2040*10)=-3.42449782852791 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: SAE1 [Title/Abstract] AND BAX [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SAE1(47646862)-BAX(49464067), # samples:3
Anticipated loss of major functional domain due to fusion event.	SAE1-BAX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SAE1-BAX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SAE1-BAX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SAE1-BAX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SAE1-BAX seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. SAE1-BAX seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. SAE1-BAX seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SAE1	GO:0016925	protein sumoylation	15660128\|20164921
Hgene	SAE1	GO:0033235	positive regulation of protein sumoylation	10187858
Tgene	BAX	GO:0001783	B cell apoptotic process	15214043\|16424160
Tgene	BAX	GO:0001836	release of cytochrome c from mitochondria	9843949\|16199525\|17052454
Tgene	BAX	GO:0006915	apoptotic process	9660918
Tgene	BAX	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	11912183
Tgene	BAX	GO:0008053	mitochondrial fusion	14769861
Tgene	BAX	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	15214043
Tgene	BAX	GO:0008637	apoptotic mitochondrial changes	9843949
Tgene	BAX	GO:0009636	response to toxic substance	16307838
Tgene	BAX	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient	9843949
Tgene	BAX	GO:0010917	negative regulation of mitochondrial membrane potential	16751333
Tgene	BAX	GO:0031334	positive regulation of protein complex assembly	9111042\|19805544
Tgene	BAX	GO:0032091	negative regulation of protein binding	9388232
Tgene	BAX	GO:0032976	release of matrix enzymes from mitochondria	9843949
Tgene	BAX	GO:0043065	positive regulation of apoptotic process	16751333\|17464193
Tgene	BAX	GO:0043525	positive regulation of neuron apoptotic process	15637643
Tgene	BAX	GO:0043653	mitochondrial fragmentation involved in apoptotic process	12499352
Tgene	BAX	GO:0051881	regulation of mitochondrial membrane potential	9843949
Tgene	BAX	GO:0090200	positive regulation of release of cytochrome c from mitochondria	14963330
Tgene	BAX	GO:0097190	apoptotic signaling pathway	16424160
Tgene	BAX	GO:0097191	extrinsic apoptotic signaling pathway	15214043
Tgene	BAX	GO:0097193	intrinsic apoptotic signaling pathway	9219694\|16462759
Tgene	BAX	GO:1990117	B cell receptor apoptotic signaling pathway	15214043

Fusion gene breakpoints across SAE1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BAX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-EJ-5532-01A	SAE1	chr19	47646862	-	BAX	chr19	49464067	+
ChimerDB4	PRAD	TCGA-EJ-5532-01A	SAE1	chr19	47646862	+	BAX	chr19	49464067	+
ChimerDB4	PRAD	TCGA-EJ-5532	SAE1	chr19	47646862	+	BAX	chr19	49464066	+
ChimerDB4	PRAD	TCGA-EJ-5532	SAE1	chr19	47646862	+	BAX	chr19	49464067	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000413379	SAE1	chr19	47646862	+	ENST00000345358	BAX	chr19	49464067	+	684	312	18	521	167
ENST00000598840	SAE1	chr19	47646862	+	ENST00000345358	BAX	chr19	49464067	+	675	303	9	512	167
ENST00000270225	SAE1	chr19	47646862	+	ENST00000345358	BAX	chr19	49464067	+	650	278	29	487	152
ENST00000392776	SAE1	chr19	47646862	+	ENST00000345358	BAX	chr19	49464067	+	618	246	36	455	139
ENST00000413379	SAE1	chr19	47646862	+	ENST00000345358	BAX	chr19	49464066	+	684	312	18	521	167
ENST00000598840	SAE1	chr19	47646862	+	ENST00000345358	BAX	chr19	49464066	+	675	303	9	512	167
ENST00000270225	SAE1	chr19	47646862	+	ENST00000345358	BAX	chr19	49464066	+	650	278	29	487	152
ENST00000392776	SAE1	chr19	47646862	+	ENST00000345358	BAX	chr19	49464066	+	618	246	36	455	139

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000413379	ENST00000345358	SAE1	chr19	47646862	+	BAX	chr19	49464067	+	0.01703373	0.9829663
ENST00000598840	ENST00000345358	SAE1	chr19	47646862	+	BAX	chr19	49464067	+	0.017170696	0.9828293
ENST00000270225	ENST00000345358	SAE1	chr19	47646862	+	BAX	chr19	49464067	+	0.019568415	0.9804316
ENST00000392776	ENST00000345358	SAE1	chr19	47646862	+	BAX	chr19	49464067	+	0.019776346	0.98022366
ENST00000413379	ENST00000345358	SAE1	chr19	47646862	+	BAX	chr19	49464066	+	0.01703373	0.9829663
ENST00000598840	ENST00000345358	SAE1	chr19	47646862	+	BAX	chr19	49464066	+	0.017170696	0.9828293
ENST00000270225	ENST00000345358	SAE1	chr19	47646862	+	BAX	chr19	49464066	+	0.019568415	0.9804316
ENST00000392776	ENST00000345358	SAE1	chr19	47646862	+	BAX	chr19	49464066	+	0.019776346	0.98022366

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>79005_79005_1_SAE1-BAX_SAE1_chr19_47646862_ENST00000270225_BAX_chr19_49464066_ENST00000345358_length(amino acids)=152AA_BP=82
MSGTGAEAGRAGAMVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQALCTKVP

--------------------------------------------------------------

>79005_79005_2_SAE1-BAX_SAE1_chr19_47646862_ENST00000270225_BAX_chr19_49464067_ENST00000345358_length(amino acids)=152AA_BP=82
MSGTGAEAGRAGAMVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQALCTKVP

--------------------------------------------------------------

>79005_79005_3_SAE1-BAX_SAE1_chr19_47646862_ENST00000392776_BAX_chr19_49464066_ENST00000345358_length(amino acids)=139AA_BP=69
MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQALCTKVPELIRTIMGWTLDF

--------------------------------------------------------------

>79005_79005_4_SAE1-BAX_SAE1_chr19_47646862_ENST00000392776_BAX_chr19_49464067_ENST00000345358_length(amino acids)=139AA_BP=69
MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQALCTKVPELIRTIMGWTLDF

--------------------------------------------------------------

>79005_79005_5_SAE1-BAX_SAE1_chr19_47646862_ENST00000413379_BAX_chr19_49464066_ENST00000345358_length(amino acids)=167AA_BP=97
MPAAVGGARVRRAVGLSGTGAEAGRAGAMVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKG

--------------------------------------------------------------

>79005_79005_6_SAE1-BAX_SAE1_chr19_47646862_ENST00000413379_BAX_chr19_49464067_ENST00000345358_length(amino acids)=167AA_BP=97
MPAAVGGARVRRAVGLSGTGAEAGRAGAMVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKG

--------------------------------------------------------------

>79005_79005_7_SAE1-BAX_SAE1_chr19_47646862_ENST00000598840_BAX_chr19_49464066_ENST00000345358_length(amino acids)=167AA_BP=97
MPAAVGGARVRRAVGLSGTGAEAGRAGAMVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKG

--------------------------------------------------------------

>79005_79005_8_SAE1-BAX_SAE1_chr19_47646862_ENST00000598840_BAX_chr19_49464067_ENST00000345358_length(amino acids)=167AA_BP=97
MPAAVGGARVRRAVGLSGTGAEAGRAGAMVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKG

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:47646862/chr19:49464067)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	BAX TMBIM6
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	237

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000293288

150_165

123.0

219.0

Motif

Note=BH2

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000345358

150_165

123.0

193.0

Motif

Note=BH2

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000354470

150_165

74.0

144.0

Motif

Note=BH2

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000354470

98_118

74.0

144.0

Motif

Note=BH1

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000391871

150_165

105.66666666666667

88.33333333333333

Motif

Note=BH2

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000415969

150_165

123.0

180.0

Motif

Note=BH2

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000293288

150_165

123.0

219.0

Motif

Note=BH2

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000345358

150_165

123.0

193.0

Motif

Note=BH2

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000354470

150_165

74.0

144.0

Motif

Note=BH2

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000354470

98_118

74.0

144.0

Motif

Note=BH1

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000391871

150_165

105.66666666666667

88.33333333333333

Motif

Note=BH2

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000415969

150_165

123.0

180.0

Motif

Note=BH2

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000293288

172_192

123.0

219.0

Transmembrane

Helical

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000345358

172_192

123.0

193.0

Transmembrane

Helical

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000354470

172_192

74.0

144.0

Transmembrane

Helical

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000391871

172_192

105.66666666666667

88.33333333333333

Transmembrane

Helical

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000415969

172_192

123.0

180.0

Transmembrane

Helical

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000539787

172_192

155.66666666666666

205.66666666666666

Transmembrane

Helical

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000293288

172_192

123.0

219.0

Transmembrane

Helical

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000345358

172_192

123.0

193.0

Transmembrane

Helical

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000354470

172_192

74.0

144.0

Transmembrane

Helical

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000391871

172_192

105.66666666666667

88.33333333333333

Transmembrane

Helical

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000415969

172_192

123.0

180.0

Transmembrane

Helical

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000539787

172_192

155.66666666666666

205.66666666666666

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000293288

59_73

123.0

219.0

Motif

Note=BH3

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000293288

98_118

123.0

219.0

Motif

Note=BH1

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000345358

59_73

123.0

193.0

Motif

Note=BH3

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000345358

98_118

123.0

193.0

Motif

Note=BH1

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000354470

59_73

74.0

144.0

Motif

Note=BH3

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000391871

59_73

105.66666666666667

88.33333333333333

Motif

Note=BH3

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000391871

98_118

105.66666666666667

88.33333333333333

Motif

Note=BH1

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000415969

59_73

123.0

180.0

Motif

Note=BH3

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000415969

98_118

123.0

180.0

Motif

Note=BH1

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000539787

150_165

155.66666666666666

205.66666666666666

Motif

Note=BH2

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000539787

59_73

155.66666666666666

205.66666666666666

Motif

Note=BH3

Tgene

BAX

chr19:47646862

chr19:49464066

ENST00000539787

98_118

155.66666666666666

205.66666666666666

Motif

Note=BH1

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000293288

59_73

123.0

219.0

Motif

Note=BH3

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000293288

98_118

123.0

219.0

Motif

Note=BH1

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000345358

59_73

123.0

193.0

Motif

Note=BH3

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000345358

98_118

123.0

193.0

Motif

Note=BH1

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000354470

59_73

74.0

144.0

Motif

Note=BH3

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000391871

59_73

105.66666666666667

88.33333333333333

Motif

Note=BH3

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000391871

98_118

105.66666666666667

88.33333333333333

Motif

Note=BH1

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000415969

59_73

123.0

180.0

Motif

Note=BH3

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000415969

98_118

123.0

180.0

Motif

Note=BH1

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000539787

150_165

155.66666666666666

205.66666666666666

Motif

Note=BH2

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000539787

59_73

155.66666666666666

205.66666666666666

Motif

Note=BH3

Tgene

BAX

chr19:47646862

chr19:49464067

ENST00000539787

98_118

155.66666666666666

205.66666666666666

Motif

Note=BH1

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>175_SAE1_47646862_BAX_49464067_ranked_0.pdb	SAE1	47646862	47646862	ENST00000345358	BAX	chr19	49464067	+	MPAAVGGARVRRAVGLSGTGAEAGRAGAMVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKG	167

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

SAE1_pLDDT.png

BAX_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
SAE1
BAX

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to SAE1-BAX

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to SAE1-BAX

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source