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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SCARB1-SUB1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SCARB1-SUB1
FusionPDB ID: 79531
FusionGDB2.0 ID: 79531
HgeneTgene
Gene symbol

SCARB1

SUB1

Gene ID

949

10923

Gene namescavenger receptor class B member 1SUB1 regulator of transcription
SynonymsCD36L1|CLA-1|CLA1|HDLQTL6|SR-BI|SRB1P15|PC4|p14
Cytomap

12q24.31

5p13.3

Type of geneprotein-codingprotein-coding
Descriptionscavenger receptor class B member 1CD36 and LIMPII analogous 1CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1scavenger receptor class B type IIIactivated RNA polymerase II transcriptional coactivator p15SUB1 homolog, transcriptional regulatoractivated RNA polymerase II transcription cofactor 4positive cofactor 4
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000261693, ENST00000339570, 
ENST00000376788, ENST00000415380, 
ENST00000546215, ENST00000535005, 
ENST00000540495, ENST00000541205, 
ENST00000544327, 		ENST00000504789, 
ENST00000265073, ENST00000502897, 
ENST00000512913, ENST00000515355, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 8 X 8=7049 X 8 X 4=288
# samples 1410
** MAII scorelog2(14/704*10)=-2.33014860169233
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/288*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SCARB1 [Title/Abstract] AND SUB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SCARB1(125348141)-SUB1(32599067), # samples:3
Anticipated loss of major functional domain due to fusion event.SCARB1-SUB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SCARB1-SUB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SCARB1-SUB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SCARB1-SUB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSCARB1

GO:0010886

positive regulation of cholesterol storage

9211901

HgeneSCARB1

GO:0015920

lipopolysaccharide transport

12651854

HgeneSCARB1

GO:0032497

detection of lipopolysaccharide

12651854

HgeneSCARB1

GO:0034384

high-density lipoprotein particle clearance

9211901

HgeneSCARB1

GO:0043654

recognition of apoptotic cell

9211901

HgeneSCARB1

GO:0051000

positive regulation of nitric-oxide synthase activity

11792700

TgeneSUB1

GO:0006357

regulation of transcription by RNA polymerase II

8062391

TgeneSUB1

GO:0051053

negative regulation of DNA metabolic process

28369605


check buttonFusion gene breakpoints across SCARB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SUB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A7AU-01ASCARB1chr12

125348141

-SUB1chr5

32599067

+
ChimerDB4PRADTCGA-KK-A7AUSCARB1chr12

125348140

-SUB1chr5

32599066

+
ChimerDB4PRADTCGA-KK-A7AUSCARB1chr12

125348141

-SUB1chr5

32599067

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000339570SCARB1chr12125348141-ENST00000512913SUB1chr532599067+6283234861162
ENST00000339570SCARB1chr12125348141-ENST00000265073SUB1chr532599067+350732332511159
ENST00000339570SCARB1chr12125348141-ENST00000515355SUB1chr532599067+7103234861162
ENST00000339570SCARB1chr12125348141-ENST00000502897SUB1chr532599067+5783234861162
ENST00000415380SCARB1chr12125348141-ENST00000512913SUB1chr532599067+55725224440138
ENST00000415380SCARB1chr12125348141-ENST00000265073SUB1chr532599067+343625224440138
ENST00000415380SCARB1chr12125348141-ENST00000515355SUB1chr532599067+63925224440138
ENST00000415380SCARB1chr12125348141-ENST00000502897SUB1chr532599067+50725224440138
ENST00000261693SCARB1chr12125348141-ENST00000512913SUB1chr532599067+5582534160139
ENST00000261693SCARB1chr12125348141-ENST00000265073SUB1chr532599067+343725325441138
ENST00000261693SCARB1chr12125348141-ENST00000515355SUB1chr532599067+6402534160139
ENST00000261693SCARB1chr12125348141-ENST00000502897SUB1chr532599067+5082534160139
ENST00000376788SCARB1chr12125348141-ENST00000512913SUB1chr532599067+5582534160139
ENST00000376788SCARB1chr12125348141-ENST00000265073SUB1chr532599067+343725325441138
ENST00000376788SCARB1chr12125348141-ENST00000515355SUB1chr532599067+6402534160139
ENST00000376788SCARB1chr12125348141-ENST00000502897SUB1chr532599067+5082534160139
ENST00000546215SCARB1chr12125348141-ENST00000512913SUB1chr532599067+49418912377121
ENST00000546215SCARB1chr12125348141-ENST00000265073SUB1chr532599067+337318912377121
ENST00000546215SCARB1chr12125348141-ENST00000515355SUB1chr532599067+57618912377121
ENST00000546215SCARB1chr12125348141-ENST00000502897SUB1chr532599067+44418912377121
ENST00000339570SCARB1chr12125348140-ENST00000512913SUB1chr532599066+6283234861162
ENST00000339570SCARB1chr12125348140-ENST00000265073SUB1chr532599066+350732332511159
ENST00000339570SCARB1chr12125348140-ENST00000515355SUB1chr532599066+7103234861162
ENST00000339570SCARB1chr12125348140-ENST00000502897SUB1chr532599066+5783234861162
ENST00000415380SCARB1chr12125348140-ENST00000512913SUB1chr532599066+55725224440138
ENST00000415380SCARB1chr12125348140-ENST00000265073SUB1chr532599066+343625224440138
ENST00000415380SCARB1chr12125348140-ENST00000515355SUB1chr532599066+63925224440138
ENST00000415380SCARB1chr12125348140-ENST00000502897SUB1chr532599066+50725224440138
ENST00000261693SCARB1chr12125348140-ENST00000512913SUB1chr532599066+5582534160139
ENST00000261693SCARB1chr12125348140-ENST00000265073SUB1chr532599066+343725325441138
ENST00000261693SCARB1chr12125348140-ENST00000515355SUB1chr532599066+6402534160139
ENST00000261693SCARB1chr12125348140-ENST00000502897SUB1chr532599066+5082534160139
ENST00000376788SCARB1chr12125348140-ENST00000512913SUB1chr532599066+5582534160139
ENST00000376788SCARB1chr12125348140-ENST00000265073SUB1chr532599066+343725325441138
ENST00000376788SCARB1chr12125348140-ENST00000515355SUB1chr532599066+6402534160139
ENST00000376788SCARB1chr12125348140-ENST00000502897SUB1chr532599066+5082534160139
ENST00000546215SCARB1chr12125348140-ENST00000512913SUB1chr532599066+49418912377121
ENST00000546215SCARB1chr12125348140-ENST00000265073SUB1chr532599066+337318912377121
ENST00000546215SCARB1chr12125348140-ENST00000515355SUB1chr532599066+57618912377121
ENST00000546215SCARB1chr12125348140-ENST00000502897SUB1chr532599066+44418912377121

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000339570ENST00000512913SCARB1chr12125348141-SUB1chr532599067+0.0499168080.95008326
ENST00000339570ENST00000265073SCARB1chr12125348141-SUB1chr532599067+0.0966412050.9033588
ENST00000339570ENST00000515355SCARB1chr12125348141-SUB1chr532599067+0.0592500530.94074994
ENST00000339570ENST00000502897SCARB1chr12125348141-SUB1chr532599067+0.0330480450.96695197
ENST00000415380ENST00000512913SCARB1chr12125348141-SUB1chr532599067+0.0509636960.9490363
ENST00000415380ENST00000265073SCARB1chr12125348141-SUB1chr532599067+0.10336110.8966389
ENST00000415380ENST00000515355SCARB1chr12125348141-SUB1chr532599067+0.069349490.9306505
ENST00000415380ENST00000502897SCARB1chr12125348141-SUB1chr532599067+0.0688926650.9311074
ENST00000261693ENST00000512913SCARB1chr12125348141-SUB1chr532599067+0.049481630.95051837
ENST00000261693ENST00000265073SCARB1chr12125348141-SUB1chr532599067+0.103773190.8962268
ENST00000261693ENST00000515355SCARB1chr12125348141-SUB1chr532599067+0.068965970.931034
ENST00000261693ENST00000502897SCARB1chr12125348141-SUB1chr532599067+0.0683553440.9316447
ENST00000376788ENST00000512913SCARB1chr12125348141-SUB1chr532599067+0.049481630.95051837
ENST00000376788ENST00000265073SCARB1chr12125348141-SUB1chr532599067+0.103773190.8962268
ENST00000376788ENST00000515355SCARB1chr12125348141-SUB1chr532599067+0.068965970.931034
ENST00000376788ENST00000502897SCARB1chr12125348141-SUB1chr532599067+0.0683553440.9316447
ENST00000546215ENST00000512913SCARB1chr12125348141-SUB1chr532599067+0.067539820.93246025
ENST00000546215ENST00000265073SCARB1chr12125348141-SUB1chr532599067+0.105525850.8944741
ENST00000546215ENST00000515355SCARB1chr12125348141-SUB1chr532599067+0.0539979970.94600195
ENST00000546215ENST00000502897SCARB1chr12125348141-SUB1chr532599067+0.085505530.91449445
ENST00000339570ENST00000512913SCARB1chr12125348140-SUB1chr532599066+0.0499168080.95008326
ENST00000339570ENST00000265073SCARB1chr12125348140-SUB1chr532599066+0.0966412050.9033588
ENST00000339570ENST00000515355SCARB1chr12125348140-SUB1chr532599066+0.0592500530.94074994
ENST00000339570ENST00000502897SCARB1chr12125348140-SUB1chr532599066+0.0330480450.96695197
ENST00000415380ENST00000512913SCARB1chr12125348140-SUB1chr532599066+0.0509636960.9490363
ENST00000415380ENST00000265073SCARB1chr12125348140-SUB1chr532599066+0.10336110.8966389
ENST00000415380ENST00000515355SCARB1chr12125348140-SUB1chr532599066+0.069349490.9306505
ENST00000415380ENST00000502897SCARB1chr12125348140-SUB1chr532599066+0.0688926650.9311074
ENST00000261693ENST00000512913SCARB1chr12125348140-SUB1chr532599066+0.049481630.95051837
ENST00000261693ENST00000265073SCARB1chr12125348140-SUB1chr532599066+0.103773190.8962268
ENST00000261693ENST00000515355SCARB1chr12125348140-SUB1chr532599066+0.068965970.931034
ENST00000261693ENST00000502897SCARB1chr12125348140-SUB1chr532599066+0.0683553440.9316447
ENST00000376788ENST00000512913SCARB1chr12125348140-SUB1chr532599066+0.049481630.95051837
ENST00000376788ENST00000265073SCARB1chr12125348140-SUB1chr532599066+0.103773190.8962268
ENST00000376788ENST00000515355SCARB1chr12125348140-SUB1chr532599066+0.068965970.931034
ENST00000376788ENST00000502897SCARB1chr12125348140-SUB1chr532599066+0.0683553440.9316447
ENST00000546215ENST00000512913SCARB1chr12125348140-SUB1chr532599066+0.067539820.93246025
ENST00000546215ENST00000265073SCARB1chr12125348140-SUB1chr532599066+0.105525850.8944741
ENST00000546215ENST00000515355SCARB1chr12125348140-SUB1chr532599066+0.0539979970.94600195
ENST00000546215ENST00000502897SCARB1chr12125348140-SUB1chr532599066+0.085505530.91449445

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>79531_79531_1_SCARB1-SUB1_SCARB1_chr12_125348140_ENST00000261693_SUB1_chr5_32599066_ENST00000265073_length(amino acids)=138AA_BP=74
MRARSPRLCRLCRRPRLLPGAEPCEPRVGPRRADMGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKIGKMRYVSVRDFKG

--------------------------------------------------------------

>79531_79531_2_SCARB1-SUB1_SCARB1_chr12_125348140_ENST00000261693_SUB1_chr5_32599066_ENST00000502897_length(amino acids)=139AA_BP=0
MSEICSFSWLHCSGFKEIPFLPGFISPSGSIQYSLISISTLPLKSRTLTYLIFPILRTCCLMSDGTITIMTAPSTAHSSPATPSAPAAQR

--------------------------------------------------------------

>79531_79531_3_SCARB1-SUB1_SCARB1_chr12_125348140_ENST00000261693_SUB1_chr5_32599066_ENST00000512913_length(amino acids)=139AA_BP=0
MSEICSFSWLHCSGFKEIPFLPGFISPSGSIQYSLISISTLPLKSRTLTYLIFPILRTCCLMSDGTITIMTAPSTAHSSPATPSAPAAQR

--------------------------------------------------------------

>79531_79531_4_SCARB1-SUB1_SCARB1_chr12_125348140_ENST00000261693_SUB1_chr5_32599066_ENST00000515355_length(amino acids)=139AA_BP=0
MSEICSFSWLHCSGFKEIPFLPGFISPSGSIQYSLISISTLPLKSRTLTYLIFPILRTCCLMSDGTITIMTAPSTAHSSPATPSAPAAQR

--------------------------------------------------------------

>79531_79531_5_SCARB1-SUB1_SCARB1_chr12_125348140_ENST00000339570_SUB1_chr5_32599066_ENST00000265073_length(amino acids)=159AA_BP=95
MATCRAAPACAAVPDPPCLCGLRARSPRLCRLCRRPRLLPGAEPCEPRVGPRRADMGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSL

--------------------------------------------------------------

>79531_79531_6_SCARB1-SUB1_SCARB1_chr12_125348140_ENST00000339570_SUB1_chr5_32599066_ENST00000502897_length(amino acids)=162AA_BP=0
MSEICSFSWLHCSGFKEIPFLPGFISPSGSIQYSLISISTLPLKSRTLTYLIFPILRTCCLMSDGTITIMTAPSTAHSSPATPSAPAAQR

--------------------------------------------------------------

>79531_79531_7_SCARB1-SUB1_SCARB1_chr12_125348140_ENST00000339570_SUB1_chr5_32599066_ENST00000512913_length(amino acids)=162AA_BP=0
MSEICSFSWLHCSGFKEIPFLPGFISPSGSIQYSLISISTLPLKSRTLTYLIFPILRTCCLMSDGTITIMTAPSTAHSSPATPSAPAAQR

--------------------------------------------------------------

>79531_79531_8_SCARB1-SUB1_SCARB1_chr12_125348140_ENST00000339570_SUB1_chr5_32599066_ENST00000515355_length(amino acids)=162AA_BP=0
MSEICSFSWLHCSGFKEIPFLPGFISPSGSIQYSLISISTLPLKSRTLTYLIFPILRTCCLMSDGTITIMTAPSTAHSSPATPSAPAAQR

--------------------------------------------------------------

>79531_79531_9_SCARB1-SUB1_SCARB1_chr12_125348140_ENST00000376788_SUB1_chr5_32599066_ENST00000265073_length(amino acids)=138AA_BP=74
MRARSPRLCRLCRRPRLLPGAEPCEPRVGPRRADMGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKIGKMRYVSVRDFKG

--------------------------------------------------------------

>79531_79531_10_SCARB1-SUB1_SCARB1_chr12_125348140_ENST00000376788_SUB1_chr5_32599066_ENST00000502897_length(amino acids)=139AA_BP=0
MSEICSFSWLHCSGFKEIPFLPGFISPSGSIQYSLISISTLPLKSRTLTYLIFPILRTCCLMSDGTITIMTAPSTAHSSPATPSAPAAQR

--------------------------------------------------------------

>79531_79531_11_SCARB1-SUB1_SCARB1_chr12_125348140_ENST00000376788_SUB1_chr5_32599066_ENST00000512913_length(amino acids)=139AA_BP=0
MSEICSFSWLHCSGFKEIPFLPGFISPSGSIQYSLISISTLPLKSRTLTYLIFPILRTCCLMSDGTITIMTAPSTAHSSPATPSAPAAQR

--------------------------------------------------------------

>79531_79531_12_SCARB1-SUB1_SCARB1_chr12_125348140_ENST00000376788_SUB1_chr5_32599066_ENST00000515355_length(amino acids)=139AA_BP=0
MSEICSFSWLHCSGFKEIPFLPGFISPSGSIQYSLISISTLPLKSRTLTYLIFPILRTCCLMSDGTITIMTAPSTAHSSPATPSAPAAQR

--------------------------------------------------------------

>79531_79531_13_SCARB1-SUB1_SCARB1_chr12_125348140_ENST00000415380_SUB1_chr5_32599066_ENST00000265073_length(amino acids)=138AA_BP=74
MRARSPRLCRLCRRPRLLPGAEPCEPRVGPRRADMGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKIGKMRYVSVRDFKG

--------------------------------------------------------------

>79531_79531_14_SCARB1-SUB1_SCARB1_chr12_125348140_ENST00000415380_SUB1_chr5_32599066_ENST00000502897_length(amino acids)=138AA_BP=74
MRARSPRLCRLCRRPRLLPGAEPCEPRVGPRRADMGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKIGKMRYVSVRDFKG

--------------------------------------------------------------

>79531_79531_15_SCARB1-SUB1_SCARB1_chr12_125348140_ENST00000415380_SUB1_chr5_32599066_ENST00000512913_length(amino acids)=138AA_BP=74
MRARSPRLCRLCRRPRLLPGAEPCEPRVGPRRADMGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKIGKMRYVSVRDFKG

--------------------------------------------------------------

>79531_79531_16_SCARB1-SUB1_SCARB1_chr12_125348140_ENST00000415380_SUB1_chr5_32599066_ENST00000515355_length(amino acids)=138AA_BP=74
MRARSPRLCRLCRRPRLLPGAEPCEPRVGPRRADMGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKIGKMRYVSVRDFKG

--------------------------------------------------------------

>79531_79531_17_SCARB1-SUB1_SCARB1_chr12_125348140_ENST00000546215_SUB1_chr5_32599066_ENST00000265073_length(amino acids)=121AA_BP=57
MPGAEPCEPRVGPRRADMGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKIGKMRYVSVRDFKGKVLIDIREYWMDPEGEM

--------------------------------------------------------------

>79531_79531_18_SCARB1-SUB1_SCARB1_chr12_125348140_ENST00000546215_SUB1_chr5_32599066_ENST00000502897_length(amino acids)=121AA_BP=57
MPGAEPCEPRVGPRRADMGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKIGKMRYVSVRDFKGKVLIDIREYWMDPEGEM

--------------------------------------------------------------

>79531_79531_19_SCARB1-SUB1_SCARB1_chr12_125348140_ENST00000546215_SUB1_chr5_32599066_ENST00000512913_length(amino acids)=121AA_BP=57
MPGAEPCEPRVGPRRADMGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKIGKMRYVSVRDFKGKVLIDIREYWMDPEGEM

--------------------------------------------------------------

>79531_79531_20_SCARB1-SUB1_SCARB1_chr12_125348140_ENST00000546215_SUB1_chr5_32599066_ENST00000515355_length(amino acids)=121AA_BP=57
MPGAEPCEPRVGPRRADMGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKIGKMRYVSVRDFKGKVLIDIREYWMDPEGEM

--------------------------------------------------------------

>79531_79531_21_SCARB1-SUB1_SCARB1_chr12_125348141_ENST00000261693_SUB1_chr5_32599067_ENST00000265073_length(amino acids)=138AA_BP=74
MRARSPRLCRLCRRPRLLPGAEPCEPRVGPRRADMGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKIGKMRYVSVRDFKG

--------------------------------------------------------------

>79531_79531_22_SCARB1-SUB1_SCARB1_chr12_125348141_ENST00000261693_SUB1_chr5_32599067_ENST00000502897_length(amino acids)=139AA_BP=0
MSEICSFSWLHCSGFKEIPFLPGFISPSGSIQYSLISISTLPLKSRTLTYLIFPILRTCCLMSDGTITIMTAPSTAHSSPATPSAPAAQR

--------------------------------------------------------------

>79531_79531_23_SCARB1-SUB1_SCARB1_chr12_125348141_ENST00000261693_SUB1_chr5_32599067_ENST00000512913_length(amino acids)=139AA_BP=0
MSEICSFSWLHCSGFKEIPFLPGFISPSGSIQYSLISISTLPLKSRTLTYLIFPILRTCCLMSDGTITIMTAPSTAHSSPATPSAPAAQR

--------------------------------------------------------------

>79531_79531_24_SCARB1-SUB1_SCARB1_chr12_125348141_ENST00000261693_SUB1_chr5_32599067_ENST00000515355_length(amino acids)=139AA_BP=0
MSEICSFSWLHCSGFKEIPFLPGFISPSGSIQYSLISISTLPLKSRTLTYLIFPILRTCCLMSDGTITIMTAPSTAHSSPATPSAPAAQR

--------------------------------------------------------------

>79531_79531_25_SCARB1-SUB1_SCARB1_chr12_125348141_ENST00000339570_SUB1_chr5_32599067_ENST00000265073_length(amino acids)=159AA_BP=95
MATCRAAPACAAVPDPPCLCGLRARSPRLCRLCRRPRLLPGAEPCEPRVGPRRADMGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSL

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>79531_79531_26_SCARB1-SUB1_SCARB1_chr12_125348141_ENST00000339570_SUB1_chr5_32599067_ENST00000502897_length(amino acids)=162AA_BP=0
MSEICSFSWLHCSGFKEIPFLPGFISPSGSIQYSLISISTLPLKSRTLTYLIFPILRTCCLMSDGTITIMTAPSTAHSSPATPSAPAAQR

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>79531_79531_27_SCARB1-SUB1_SCARB1_chr12_125348141_ENST00000339570_SUB1_chr5_32599067_ENST00000512913_length(amino acids)=162AA_BP=0
MSEICSFSWLHCSGFKEIPFLPGFISPSGSIQYSLISISTLPLKSRTLTYLIFPILRTCCLMSDGTITIMTAPSTAHSSPATPSAPAAQR

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>79531_79531_28_SCARB1-SUB1_SCARB1_chr12_125348141_ENST00000339570_SUB1_chr5_32599067_ENST00000515355_length(amino acids)=162AA_BP=0
MSEICSFSWLHCSGFKEIPFLPGFISPSGSIQYSLISISTLPLKSRTLTYLIFPILRTCCLMSDGTITIMTAPSTAHSSPATPSAPAAQR

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>79531_79531_29_SCARB1-SUB1_SCARB1_chr12_125348141_ENST00000376788_SUB1_chr5_32599067_ENST00000265073_length(amino acids)=138AA_BP=74
MRARSPRLCRLCRRPRLLPGAEPCEPRVGPRRADMGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKIGKMRYVSVRDFKG

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>79531_79531_30_SCARB1-SUB1_SCARB1_chr12_125348141_ENST00000376788_SUB1_chr5_32599067_ENST00000502897_length(amino acids)=139AA_BP=0
MSEICSFSWLHCSGFKEIPFLPGFISPSGSIQYSLISISTLPLKSRTLTYLIFPILRTCCLMSDGTITIMTAPSTAHSSPATPSAPAAQR

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>79531_79531_31_SCARB1-SUB1_SCARB1_chr12_125348141_ENST00000376788_SUB1_chr5_32599067_ENST00000512913_length(amino acids)=139AA_BP=0
MSEICSFSWLHCSGFKEIPFLPGFISPSGSIQYSLISISTLPLKSRTLTYLIFPILRTCCLMSDGTITIMTAPSTAHSSPATPSAPAAQR

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>79531_79531_32_SCARB1-SUB1_SCARB1_chr12_125348141_ENST00000376788_SUB1_chr5_32599067_ENST00000515355_length(amino acids)=139AA_BP=0
MSEICSFSWLHCSGFKEIPFLPGFISPSGSIQYSLISISTLPLKSRTLTYLIFPILRTCCLMSDGTITIMTAPSTAHSSPATPSAPAAQR

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>79531_79531_33_SCARB1-SUB1_SCARB1_chr12_125348141_ENST00000415380_SUB1_chr5_32599067_ENST00000265073_length(amino acids)=138AA_BP=74
MRARSPRLCRLCRRPRLLPGAEPCEPRVGPRRADMGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKIGKMRYVSVRDFKG

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>79531_79531_34_SCARB1-SUB1_SCARB1_chr12_125348141_ENST00000415380_SUB1_chr5_32599067_ENST00000502897_length(amino acids)=138AA_BP=74
MRARSPRLCRLCRRPRLLPGAEPCEPRVGPRRADMGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKIGKMRYVSVRDFKG

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>79531_79531_35_SCARB1-SUB1_SCARB1_chr12_125348141_ENST00000415380_SUB1_chr5_32599067_ENST00000512913_length(amino acids)=138AA_BP=74
MRARSPRLCRLCRRPRLLPGAEPCEPRVGPRRADMGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKIGKMRYVSVRDFKG

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>79531_79531_36_SCARB1-SUB1_SCARB1_chr12_125348141_ENST00000415380_SUB1_chr5_32599067_ENST00000515355_length(amino acids)=138AA_BP=74
MRARSPRLCRLCRRPRLLPGAEPCEPRVGPRRADMGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKIGKMRYVSVRDFKG

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>79531_79531_37_SCARB1-SUB1_SCARB1_chr12_125348141_ENST00000546215_SUB1_chr5_32599067_ENST00000265073_length(amino acids)=121AA_BP=57
MPGAEPCEPRVGPRRADMGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKIGKMRYVSVRDFKGKVLIDIREYWMDPEGEM

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>79531_79531_38_SCARB1-SUB1_SCARB1_chr12_125348141_ENST00000546215_SUB1_chr5_32599067_ENST00000502897_length(amino acids)=121AA_BP=57
MPGAEPCEPRVGPRRADMGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKIGKMRYVSVRDFKGKVLIDIREYWMDPEGEM

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>79531_79531_39_SCARB1-SUB1_SCARB1_chr12_125348141_ENST00000546215_SUB1_chr5_32599067_ENST00000512913_length(amino acids)=121AA_BP=57
MPGAEPCEPRVGPRRADMGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKIGKMRYVSVRDFKGKVLIDIREYWMDPEGEM

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>79531_79531_40_SCARB1-SUB1_SCARB1_chr12_125348141_ENST00000546215_SUB1_chr5_32599067_ENST00000515355_length(amino acids)=121AA_BP=57
MPGAEPCEPRVGPRRADMGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKIGKMRYVSVRDFKGKVLIDIREYWMDPEGEM

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:125348141/chr5:32599067)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCARB1chr12:125348140chr5:32599066ENST00000261693-1131_1142.0734.0Topological domainCytoplasmic
HgeneSCARB1chr12:125348140chr5:32599066ENST00000376788-1111_1142.0616.3333333333334Topological domainCytoplasmic
HgeneSCARB1chr12:125348140chr5:32599066ENST00000415380-1121_1142.0553.0Topological domainCytoplasmic
HgeneSCARB1chr12:125348141chr5:32599067ENST00000261693-1131_1142.0734.0Topological domainCytoplasmic
HgeneSCARB1chr12:125348141chr5:32599067ENST00000376788-1111_1142.0616.3333333333334Topological domainCytoplasmic
HgeneSCARB1chr12:125348141chr5:32599067ENST00000415380-1121_1142.0553.0Topological domainCytoplasmic
HgeneSCARB1chr12:125348140chr5:32599066ENST00000261693-11312_3242.0734.0TransmembraneHelical
HgeneSCARB1chr12:125348140chr5:32599066ENST00000376788-11112_3242.0616.3333333333334TransmembraneHelical
HgeneSCARB1chr12:125348140chr5:32599066ENST00000415380-11212_3242.0553.0TransmembraneHelical
HgeneSCARB1chr12:125348141chr5:32599067ENST00000261693-11312_3242.0734.0TransmembraneHelical
HgeneSCARB1chr12:125348141chr5:32599067ENST00000376788-11112_3242.0616.3333333333334TransmembraneHelical
HgeneSCARB1chr12:125348141chr5:32599067ENST00000415380-11212_3242.0553.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCARB1chr12:125348140chr5:32599066ENST00000261693-11333_44342.0734.0Topological domainExtracellular
HgeneSCARB1chr12:125348140chr5:32599066ENST00000261693-113465_55242.0734.0Topological domainCytoplasmic
HgeneSCARB1chr12:125348140chr5:32599066ENST00000376788-11133_44342.0616.3333333333334Topological domainExtracellular
HgeneSCARB1chr12:125348140chr5:32599066ENST00000376788-111465_55242.0616.3333333333334Topological domainCytoplasmic
HgeneSCARB1chr12:125348140chr5:32599066ENST00000415380-11233_44342.0553.0Topological domainExtracellular
HgeneSCARB1chr12:125348140chr5:32599066ENST00000415380-112465_55242.0553.0Topological domainCytoplasmic
HgeneSCARB1chr12:125348141chr5:32599067ENST00000261693-11333_44342.0734.0Topological domainExtracellular
HgeneSCARB1chr12:125348141chr5:32599067ENST00000261693-113465_55242.0734.0Topological domainCytoplasmic
HgeneSCARB1chr12:125348141chr5:32599067ENST00000376788-11133_44342.0616.3333333333334Topological domainExtracellular
HgeneSCARB1chr12:125348141chr5:32599067ENST00000376788-111465_55242.0616.3333333333334Topological domainCytoplasmic
HgeneSCARB1chr12:125348141chr5:32599067ENST00000415380-11233_44342.0553.0Topological domainExtracellular
HgeneSCARB1chr12:125348141chr5:32599067ENST00000415380-112465_55242.0553.0Topological domainCytoplasmic
HgeneSCARB1chr12:125348140chr5:32599066ENST00000261693-113444_46442.0734.0TransmembraneHelical
HgeneSCARB1chr12:125348140chr5:32599066ENST00000376788-111444_46442.0616.3333333333334TransmembraneHelical
HgeneSCARB1chr12:125348140chr5:32599066ENST00000415380-112444_46442.0553.0TransmembraneHelical
HgeneSCARB1chr12:125348141chr5:32599067ENST00000261693-113444_46442.0734.0TransmembraneHelical
HgeneSCARB1chr12:125348141chr5:32599067ENST00000376788-111444_46442.0616.3333333333334TransmembraneHelical
HgeneSCARB1chr12:125348141chr5:32599067ENST00000415380-112444_46442.0553.0TransmembraneHelical
TgeneSUB1chr12:125348140chr5:32599066ENST000002650732523_5365.0128.0Compositional biasNote=Lys-rich
TgeneSUB1chr12:125348140chr5:32599066ENST00000265073254_1965.0128.0Compositional biasNote=Ser-rich
TgeneSUB1chr12:125348140chr5:32599066ENST000002650732550_5865.0128.0Compositional biasNote=Ser-rich
TgeneSUB1chr12:125348140chr5:32599066ENST000005028973623_5365.0128.0Compositional biasNote=Lys-rich
TgeneSUB1chr12:125348140chr5:32599066ENST00000502897364_1965.0128.0Compositional biasNote=Ser-rich
TgeneSUB1chr12:125348140chr5:32599066ENST000005028973650_5865.0128.0Compositional biasNote=Ser-rich
TgeneSUB1chr12:125348140chr5:32599066ENST000005129133623_5365.0128.0Compositional biasNote=Lys-rich
TgeneSUB1chr12:125348140chr5:32599066ENST00000512913364_1965.0128.0Compositional biasNote=Ser-rich
TgeneSUB1chr12:125348140chr5:32599066ENST000005129133650_5865.0128.0Compositional biasNote=Ser-rich
TgeneSUB1chr12:125348140chr5:32599066ENST000005153553623_5365.0128.0Compositional biasNote=Lys-rich
TgeneSUB1chr12:125348140chr5:32599066ENST00000515355364_1965.0128.0Compositional biasNote=Ser-rich
TgeneSUB1chr12:125348140chr5:32599066ENST000005153553650_5865.0128.0Compositional biasNote=Ser-rich
TgeneSUB1chr12:125348141chr5:32599067ENST000002650732523_5365.0128.0Compositional biasNote=Lys-rich
TgeneSUB1chr12:125348141chr5:32599067ENST00000265073254_1965.0128.0Compositional biasNote=Ser-rich
TgeneSUB1chr12:125348141chr5:32599067ENST000002650732550_5865.0128.0Compositional biasNote=Ser-rich
TgeneSUB1chr12:125348141chr5:32599067ENST000005028973623_5365.0128.0Compositional biasNote=Lys-rich
TgeneSUB1chr12:125348141chr5:32599067ENST00000502897364_1965.0128.0Compositional biasNote=Ser-rich
TgeneSUB1chr12:125348141chr5:32599067ENST000005028973650_5865.0128.0Compositional biasNote=Ser-rich
TgeneSUB1chr12:125348141chr5:32599067ENST000005129133623_5365.0128.0Compositional biasNote=Lys-rich
TgeneSUB1chr12:125348141chr5:32599067ENST00000512913364_1965.0128.0Compositional biasNote=Ser-rich
TgeneSUB1chr12:125348141chr5:32599067ENST000005129133650_5865.0128.0Compositional biasNote=Ser-rich
TgeneSUB1chr12:125348141chr5:32599067ENST000005153553623_5365.0128.0Compositional biasNote=Lys-rich
TgeneSUB1chr12:125348141chr5:32599067ENST00000515355364_1965.0128.0Compositional biasNote=Ser-rich
TgeneSUB1chr12:125348141chr5:32599067ENST000005153553650_5865.0128.0Compositional biasNote=Ser-rich
TgeneSUB1chr12:125348140chr5:32599066ENST00000265073252_5065.0128.0RegionNote=Regulatory
TgeneSUB1chr12:125348140chr5:32599066ENST00000502897362_5065.0128.0RegionNote=Regulatory
TgeneSUB1chr12:125348140chr5:32599066ENST00000512913362_5065.0128.0RegionNote=Regulatory
TgeneSUB1chr12:125348140chr5:32599066ENST00000515355362_5065.0128.0RegionNote=Regulatory
TgeneSUB1chr12:125348141chr5:32599067ENST00000265073252_5065.0128.0RegionNote=Regulatory
TgeneSUB1chr12:125348141chr5:32599067ENST00000502897362_5065.0128.0RegionNote=Regulatory
TgeneSUB1chr12:125348141chr5:32599067ENST00000512913362_5065.0128.0RegionNote=Regulatory
TgeneSUB1chr12:125348141chr5:32599067ENST00000515355362_5065.0128.0RegionNote=Regulatory


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>154_SCARB1_125348141_SUB1_32599067_ranked_0.pdbSCARB1125348140125348141ENST00000502897SUB1chr532599067+
MSEICSFSWLHCSGFKEIPFLPGFISPSGSIQYSLISISTLPLKSRTLTYLIFPILRTCCLMSDGTITIMTAPSTAHSSPATPSAPAAQR
162


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SCARB1_pLDDT.png
all structure
all structure
SUB1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SCARB1
SUB1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SCARB1-SUB1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SCARB1-SUB1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource