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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SCN8A-ATF1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SCN8A-ATF1
FusionPDB ID: 79692
FusionGDB2.0 ID: 79692
HgeneTgene
Gene symbol

SCN8A

ATF1

Gene ID

6334

2668

Gene namesodium voltage-gated channel alpha subunit 8glial cell derived neurotrophic factor
SynonymsBFIS5|CERIII|CIAT|EIEE13|MED|MYOCL2|NaCh6|Nav1.6|PN4ATF|ATF1|ATF2|HFB1-GDNF|HSCR3
Cytomap

12q13.13

5p13.2

Type of geneprotein-codingprotein-coding
Descriptionsodium channel protein type 8 subunit alphahNa6/Scn8a voltage-gated sodium channelsodium channel, voltage gated, type VIII, alpha subunitvoltage-gated sodium channel subunit alpha Nav1.6voltage-gated sodium channel type VIII alpha proteinglial cell line-derived neurotrophic factorastrocyte-derived trophic factor
Modification date2020031320200314
UniProtAcc.

P18846

Ensembl transtripts involved in fusion geneENST idsENST00000354534, ENST00000545061, 
ENST00000546961, ENST00000550891, 
ENST00000539132, ENST00000262053, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 8 X 5=28010 X 16 X 7=1120
# samples 816
** MAII scorelog2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1120*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SCN8A [Title/Abstract] AND ATF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SCN8A(52184286)-ATF1(51189692), # samples:3
Anticipated loss of major functional domain due to fusion event.SCN8A-ATF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SCN8A-ATF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SCN8A-ATF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SCN8A-ATF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneATF1

GO:0001755

neural crest cell migration

15242795

TgeneATF1

GO:0008284

positive regulation of cell proliferation

22897442

TgeneATF1

GO:0031175

neuron projection development

15242795

TgeneATF1

GO:0032770

positive regulation of monooxygenase activity

12358785

TgeneATF1

GO:0043524

negative regulation of neuron apoptotic process

8493557

TgeneATF1

GO:0045944

positive regulation of transcription by RNA polymerase II

12358785

TgeneATF1

GO:0048255

mRNA stabilization

12358785

TgeneATF1

GO:0051584

regulation of dopamine uptake involved in synaptic transmission

8493557

TgeneATF1

GO:0072107

positive regulation of ureteric bud formation

8657307

TgeneATF1

GO:0090190

positive regulation of branching involved in ureteric bud morphogenesis

8657307|17229286

TgeneATF1

GO:2001240

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

10921886


check buttonFusion gene breakpoints across SCN8A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ATF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DH-A66G-01ASCN8Achr12

52184286

-ATF1chr12

51189692

+
ChimerDB4LGGTCGA-DH-A66G-01ASCN8Achr12

52184286

+ATF1chr12

51189692

+
ChimerDB4LGGTCGA-DH-A66GSCN8Achr12

52184286

+ATF1chr12

51189691

+
ChimerDB4LGGTCGA-DH-A66GSCN8Achr12

52184286

+ATF1chr12

51189692

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000354534SCN8Achr1252184286+ENST00000262053ATF1chr1251189692+6768470216054241754
ENST00000545061SCN8Achr1252184286+ENST00000262053ATF1chr1251189692+652144553651771713
ENST00000354534SCN8Achr1252184286+ENST00000262053ATF1chr1251189691+6768470216054241754
ENST00000545061SCN8Achr1252184286+ENST00000262053ATF1chr1251189691+652144553651771713

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000354534ENST00000262053SCN8Achr1252184286+ATF1chr1251189692+0.0004251530.99957484
ENST00000545061ENST00000262053SCN8Achr1252184286+ATF1chr1251189692+0.0005499390.99945
ENST00000354534ENST00000262053SCN8Achr1252184286+ATF1chr1251189691+0.0004251530.99957484
ENST00000545061ENST00000262053SCN8Achr1252184286+ATF1chr1251189691+0.0005499390.99945

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>79692_79692_1_SCN8A-ATF1_SCN8A_chr12_52184286_ENST00000354534_ATF1_chr12_51189691_ENST00000262053_length(amino acids)=1754AA_BP=1514
MLQDEKMAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDF
DPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESL
VKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV
FALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFD
TFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQE
EAQAAAMATSAGTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDN
RIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGS
RSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHIGGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEE
SQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKL
IAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM
QLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADN
LAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSV
EKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEG
CVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAY
GFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIM
GVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKY
EDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLVSSLSESEESQDSSDS
IGSSQKAHGILARRPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQLASPGTDGVQGLQTLTMT
NSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAA

--------------------------------------------------------------

>79692_79692_2_SCN8A-ATF1_SCN8A_chr12_52184286_ENST00000354534_ATF1_chr12_51189692_ENST00000262053_length(amino acids)=1754AA_BP=1514
MLQDEKMAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDF
DPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESL
VKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV
FALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFD
TFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQE
EAQAAAMATSAGTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDN
RIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGS
RSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHIGGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEE
SQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKL
IAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM
QLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADN
LAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSV
EKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEG
CVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAY
GFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIM
GVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKY
EDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLVSSLSESEESQDSSDS
IGSSQKAHGILARRPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQLASPGTDGVQGLQTLTMT
NSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAA

--------------------------------------------------------------

>79692_79692_3_SCN8A-ATF1_SCN8A_chr12_52184286_ENST00000545061_ATF1_chr12_51189691_ENST00000262053_length(amino acids)=1713AA_BP=1473
MLQDEKMAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDF
DPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESL
VKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV
FALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFD
TFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQE
EAQAAAMATSAGTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDN
RIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGS
RSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHIGGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEE
SQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKL
IAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM
QLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADN
LAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSV
EKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEG
CVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAY
GFVKFFTNAWCWLDFLIVAVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNT
EIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFG
GQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLVSSLSESEESQDSSDSIGSSQKAHGILARRPSYRKILKDLSSEDTRGRKGDGENSGV
SAAVTSMSVPTPIYQTSSGQYIAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQT
YQIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLYSN

--------------------------------------------------------------

>79692_79692_4_SCN8A-ATF1_SCN8A_chr12_52184286_ENST00000545061_ATF1_chr12_51189692_ENST00000262053_length(amino acids)=1713AA_BP=1473
MLQDEKMAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDF
DPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESL
VKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV
FALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFD
TFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQE
EAQAAAMATSAGTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDN
RIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGS
RSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHIGGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEE
SQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKL
IAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM
QLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADN
LAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSV
EKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEG
CVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAY
GFVKFFTNAWCWLDFLIVAVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNT
EIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFG
GQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLVSSLSESEESQDSSDSIGSSQKAHGILARRPSYRKILKDLSSEDTRGRKGDGENSGV
SAAVTSMSVPTPIYQTSSGQYIAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQT
YQIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLYSN

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:52184286/chr12:51189692)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ATF1

P18846

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. {ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:20980392}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271400_14211508.01981.0IntramembranePore-forming
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527356_3801508.01981.0IntramembranePore-forming
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527922_9421508.01981.0IntramembranePore-forming
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251400_14211467.01940.0IntramembranePore-forming
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325356_3801467.01940.0IntramembranePore-forming
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325922_9421467.01940.0IntramembranePore-forming
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271400_14211508.01981.0IntramembranePore-forming
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527356_3801508.01981.0IntramembranePore-forming
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527922_9421508.01981.0IntramembranePore-forming
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251400_14211467.01940.0IntramembranePore-forming
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325356_3801467.01940.0IntramembranePore-forming
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325922_9421467.01940.0IntramembranePore-forming
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527893_9001508.01981.0Nucleotide bindingATP
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325893_9001467.01940.0Nucleotide bindingATP
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527893_9001508.01981.0Nucleotide bindingATP
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325893_9001467.01940.0Nucleotide bindingATP
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527114_4421508.01981.0RepeatI
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271180_14951508.01981.0RepeatIII
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527735_10071508.01981.0RepeatII
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325114_4421467.01940.0RepeatI
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325735_10071467.01940.0RepeatII
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527114_4421508.01981.0RepeatI
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271180_14951508.01981.0RepeatIII
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527735_10071508.01981.0RepeatII
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325114_4421467.01940.0RepeatI
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325735_10071467.01940.0RepeatII
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271218_12301508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271250_12631508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271283_12901508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271310_13261508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271347_13991508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271422_14381508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527152_1581508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527180_1931508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271_1321508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527212_2171508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527235_2531508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527274_3551508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527381_3871508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527409_7531508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527773_7831508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527804_8171508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527838_8391508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527858_8731508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527893_9211508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527943_9551508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527977_11991508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251218_12301467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251250_12631467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251283_12901467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251310_13261467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251347_13991467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251422_14381467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325152_1581467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325180_1931467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251_1321467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325212_2171467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325235_2531467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325274_3551467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325381_3871467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325409_7531467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325773_7831467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325804_8171467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325838_8391467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325858_8731467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325893_9211467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325943_9551467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325977_11991467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271218_12301508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271250_12631508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271283_12901508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271310_13261508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271347_13991508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271422_14381508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527152_1581508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527180_1931508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271_1321508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527212_2171508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527235_2531508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527274_3551508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527381_3871508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527409_7531508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527773_7831508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527804_8171508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527838_8391508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527858_8731508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527893_9211508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527943_9551508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527977_11991508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251218_12301467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251250_12631467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251283_12901467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251310_13261467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251347_13991467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251422_14381467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325152_1581467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325180_1931467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251_1321467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325212_2171467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325235_2531467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325274_3551467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325381_3871467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325409_7531467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325773_7831467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325804_8171467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325838_8391467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325858_8731467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325893_9211467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325943_9551467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325977_11991467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271200_12171508.01981.0TransmembraneHelical%3B Name%3DS1 of repeat III
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271231_12491508.01981.0TransmembraneHelical%3B Name%3DS2 of repeat III
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271264_12821508.01981.0TransmembraneHelical%3B Name%3DS3 of repeat III
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271291_13091508.01981.0TransmembraneHelical%3B Name%3DS4 of repeat III
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271327_13461508.01981.0TransmembraneHelical%3B Name%3DS5 of repeat III
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527133_1511508.01981.0TransmembraneHelical%3B Name%3DS1 of repeat I
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271439_14601508.01981.0TransmembraneHelical%3B Name%3DS6 of repeat III
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527159_1791508.01981.0TransmembraneHelical%3B Name%3DS2 of repeat I
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527194_2111508.01981.0TransmembraneHelical%3B Name%3DS3 of repeat I
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527218_2341508.01981.0TransmembraneHelical%3B Name%3DS4 of repeat I
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527254_2731508.01981.0TransmembraneHelical%3B Name%3DS5 of repeat I
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527388_4081508.01981.0TransmembraneHelical%3B Name%3DS6 of repeat I
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527754_7721508.01981.0TransmembraneHelical%3B Name%3DS1 of repeat II
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527784_8031508.01981.0TransmembraneHelical%3B Name%3DS2 of repeat II
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527818_8371508.01981.0TransmembraneHelical%3B Name%3DS3 of repeat II
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527840_8571508.01981.0TransmembraneHelical%3B Name%3DS4 of repeat II
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527874_8921508.01981.0TransmembraneHelical%3B Name%3DS5 of repeat II
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+2527956_9761508.01981.0TransmembraneHelical%3B Name%3DS6 of repeat II
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251200_12171467.01940.0TransmembraneHelical%3B Name%3DS1 of repeat III
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251231_12491467.01940.0TransmembraneHelical%3B Name%3DS2 of repeat III
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251264_12821467.01940.0TransmembraneHelical%3B Name%3DS3 of repeat III
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251291_13091467.01940.0TransmembraneHelical%3B Name%3DS4 of repeat III
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251327_13461467.01940.0TransmembraneHelical%3B Name%3DS5 of repeat III
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325133_1511467.01940.0TransmembraneHelical%3B Name%3DS1 of repeat I
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251439_14601467.01940.0TransmembraneHelical%3B Name%3DS6 of repeat III
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325159_1791467.01940.0TransmembraneHelical%3B Name%3DS2 of repeat I
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325194_2111467.01940.0TransmembraneHelical%3B Name%3DS3 of repeat I
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325218_2341467.01940.0TransmembraneHelical%3B Name%3DS4 of repeat I
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325254_2731467.01940.0TransmembraneHelical%3B Name%3DS5 of repeat I
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325388_4081467.01940.0TransmembraneHelical%3B Name%3DS6 of repeat I
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325754_7721467.01940.0TransmembraneHelical%3B Name%3DS1 of repeat II
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325784_8031467.01940.0TransmembraneHelical%3B Name%3DS2 of repeat II
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325818_8371467.01940.0TransmembraneHelical%3B Name%3DS3 of repeat II
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325840_8571467.01940.0TransmembraneHelical%3B Name%3DS4 of repeat II
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325874_8921467.01940.0TransmembraneHelical%3B Name%3DS5 of repeat II
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+2325956_9761467.01940.0TransmembraneHelical%3B Name%3DS6 of repeat II
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271200_12171508.01981.0TransmembraneHelical%3B Name%3DS1 of repeat III
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271231_12491508.01981.0TransmembraneHelical%3B Name%3DS2 of repeat III
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271264_12821508.01981.0TransmembraneHelical%3B Name%3DS3 of repeat III
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271291_13091508.01981.0TransmembraneHelical%3B Name%3DS4 of repeat III
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271327_13461508.01981.0TransmembraneHelical%3B Name%3DS5 of repeat III
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527133_1511508.01981.0TransmembraneHelical%3B Name%3DS1 of repeat I
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271439_14601508.01981.0TransmembraneHelical%3B Name%3DS6 of repeat III
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527159_1791508.01981.0TransmembraneHelical%3B Name%3DS2 of repeat I
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527194_2111508.01981.0TransmembraneHelical%3B Name%3DS3 of repeat I
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527218_2341508.01981.0TransmembraneHelical%3B Name%3DS4 of repeat I
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527254_2731508.01981.0TransmembraneHelical%3B Name%3DS5 of repeat I
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527388_4081508.01981.0TransmembraneHelical%3B Name%3DS6 of repeat I
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527754_7721508.01981.0TransmembraneHelical%3B Name%3DS1 of repeat II
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527784_8031508.01981.0TransmembraneHelical%3B Name%3DS2 of repeat II
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527818_8371508.01981.0TransmembraneHelical%3B Name%3DS3 of repeat II
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527840_8571508.01981.0TransmembraneHelical%3B Name%3DS4 of repeat II
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527874_8921508.01981.0TransmembraneHelical%3B Name%3DS5 of repeat II
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+2527956_9761508.01981.0TransmembraneHelical%3B Name%3DS6 of repeat II
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251200_12171467.01940.0TransmembraneHelical%3B Name%3DS1 of repeat III
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251231_12491467.01940.0TransmembraneHelical%3B Name%3DS2 of repeat III
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251264_12821467.01940.0TransmembraneHelical%3B Name%3DS3 of repeat III
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251291_13091467.01940.0TransmembraneHelical%3B Name%3DS4 of repeat III
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251327_13461467.01940.0TransmembraneHelical%3B Name%3DS5 of repeat III
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325133_1511467.01940.0TransmembraneHelical%3B Name%3DS1 of repeat I
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251439_14601467.01940.0TransmembraneHelical%3B Name%3DS6 of repeat III
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325159_1791467.01940.0TransmembraneHelical%3B Name%3DS2 of repeat I
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325194_2111467.01940.0TransmembraneHelical%3B Name%3DS3 of repeat I
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325218_2341467.01940.0TransmembraneHelical%3B Name%3DS4 of repeat I
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325254_2731467.01940.0TransmembraneHelical%3B Name%3DS5 of repeat I
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325388_4081467.01940.0TransmembraneHelical%3B Name%3DS6 of repeat I
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325754_7721467.01940.0TransmembraneHelical%3B Name%3DS1 of repeat II
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325784_8031467.01940.0TransmembraneHelical%3B Name%3DS2 of repeat II
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325818_8371467.01940.0TransmembraneHelical%3B Name%3DS3 of repeat II
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325840_8571467.01940.0TransmembraneHelical%3B Name%3DS4 of repeat II
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325874_8921467.01940.0TransmembraneHelical%3B Name%3DS5 of repeat II
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+2325956_9761467.01940.0TransmembraneHelical%3B Name%3DS6 of repeat II
TgeneATF1chr12:52184286chr12:51189691ENST0000026205317213_27131.0272.0DomainbZIP
TgeneATF1chr12:52184286chr12:51189691ENST000002620531731_9031.0272.0DomainKID
TgeneATF1chr12:52184286chr12:51189692ENST0000026205317213_27131.0272.0DomainbZIP
TgeneATF1chr12:52184286chr12:51189692ENST000002620531731_9031.0272.0DomainKID
TgeneATF1chr12:52184286chr12:51189691ENST0000026205317215_23931.0272.0RegionBasic motif
TgeneATF1chr12:52184286chr12:51189691ENST0000026205317241_26231.0272.0RegionLeucine-zipper
TgeneATF1chr12:52184286chr12:51189692ENST0000026205317215_23931.0272.0RegionBasic motif
TgeneATF1chr12:52184286chr12:51189692ENST0000026205317241_26231.0272.0RegionLeucine-zipper

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271895_19241508.01981.0DomainIQ
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251895_19241467.01940.0DomainIQ
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271895_19241508.01981.0DomainIQ
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251895_19241467.01940.0DomainIQ
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271691_17131508.01981.0IntramembranePore-forming
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251691_17131467.01940.0IntramembranePore-forming
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271691_17131508.01981.0IntramembranePore-forming
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251691_17131467.01940.0IntramembranePore-forming
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271504_18011508.01981.0RepeatIV
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251180_14951467.01940.0RepeatIII
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251504_18011467.01940.0RepeatIV
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271504_18011508.01981.0RepeatIV
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251180_14951467.01940.0RepeatIII
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251504_18011467.01940.0RepeatIV
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271461_15231508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271542_15521508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271572_15831508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271602_16141508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271632_16501508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271669_16901508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271714_17421508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271766_19801508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251461_15231467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251542_15521467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251572_15831467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251602_16141467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251632_16501467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251669_16901467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251714_17421467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251766_19801467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271461_15231508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271542_15521508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271572_15831508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271602_16141508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271632_16501508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271669_16901508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271714_17421508.01981.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271766_19801508.01981.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251461_15231467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251542_15521467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251572_15831467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251602_16141467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251632_16501467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251669_16901467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251714_17421467.01940.0Topological domainExtracellular
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251766_19801467.01940.0Topological domainCytoplasmic
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271524_15411508.01981.0TransmembraneHelical%3B Name%3DS1 of repeat IV
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271553_15711508.01981.0TransmembraneHelical%3B Name%3DS2 of repeat IV
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271584_16011508.01981.0TransmembraneHelical%3B Name%3DS3 of repeat IV
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271615_16311508.01981.0TransmembraneHelical%3B Name%3DS4 of repeat IV
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271651_16681508.01981.0TransmembraneHelical%3B Name%3DS5 of repeat IV
HgeneSCN8Achr12:52184286chr12:51189691ENST00000354534+25271743_17651508.01981.0TransmembraneHelical%3B Name%3DS6 of repeat IV
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251524_15411467.01940.0TransmembraneHelical%3B Name%3DS1 of repeat IV
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251553_15711467.01940.0TransmembraneHelical%3B Name%3DS2 of repeat IV
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251584_16011467.01940.0TransmembraneHelical%3B Name%3DS3 of repeat IV
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251615_16311467.01940.0TransmembraneHelical%3B Name%3DS4 of repeat IV
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251651_16681467.01940.0TransmembraneHelical%3B Name%3DS5 of repeat IV
HgeneSCN8Achr12:52184286chr12:51189691ENST00000545061+23251743_17651467.01940.0TransmembraneHelical%3B Name%3DS6 of repeat IV
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271524_15411508.01981.0TransmembraneHelical%3B Name%3DS1 of repeat IV
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271553_15711508.01981.0TransmembraneHelical%3B Name%3DS2 of repeat IV
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271584_16011508.01981.0TransmembraneHelical%3B Name%3DS3 of repeat IV
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271615_16311508.01981.0TransmembraneHelical%3B Name%3DS4 of repeat IV
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271651_16681508.01981.0TransmembraneHelical%3B Name%3DS5 of repeat IV
HgeneSCN8Achr12:52184286chr12:51189692ENST00000354534+25271743_17651508.01981.0TransmembraneHelical%3B Name%3DS6 of repeat IV
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251524_15411467.01940.0TransmembraneHelical%3B Name%3DS1 of repeat IV
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251553_15711467.01940.0TransmembraneHelical%3B Name%3DS2 of repeat IV
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251584_16011467.01940.0TransmembraneHelical%3B Name%3DS3 of repeat IV
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251615_16311467.01940.0TransmembraneHelical%3B Name%3DS4 of repeat IV
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251651_16681467.01940.0TransmembraneHelical%3B Name%3DS5 of repeat IV
HgeneSCN8Achr12:52184286chr12:51189692ENST00000545061+23251743_17651467.01940.0TransmembraneHelical%3B Name%3DS6 of repeat IV


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SCN8A_pLDDT.png
all structure
all structure
ATF1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SCN8A
ATF1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SCN8A-ATF1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SCN8A-ATF1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneATF1C0032460Polycystic Ovary Syndrome1CTD_human
TgeneATF1C0206651Clear Cell Sarcoma of Soft Tissue1ORPHANET
TgeneATF1C1136382Sclerocystic Ovaries1CTD_human