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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SCUBE2-DENND5A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SCUBE2-DENND5A
FusionPDB ID: 79753
FusionGDB2.0 ID: 79753
HgeneTgene
Gene symbol

SCUBE2

DENND5A

Gene ID

57758

23258

Gene namesignal peptide, CUB domain and EGF like domain containing 2DENN domain containing 5A
SynonymsCEGB1|CEGF1|CEGP1|scube/YouEIEE49|RAB6IP1
Cytomap

11p15.4

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionsignal peptide, CUB and EGF-like domain-containing protein 2DENN domain-containing protein 5ADENN/MADD domain containing 5ARAB6 interacting protein 1rab6-interacting protein 1
Modification date2020031320200313
UniProtAcc.

Q6IQ26

Ensembl transtripts involved in fusion geneENST idsENST00000309263, ENST00000450649, 
ENST00000457346, ENST00000520467, 
ENST00000534295, 		ENST00000527700, 
ENST00000526523, ENST00000328194, 
ENST00000530044, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 6 X 4=14415 X 15 X 6=1350
# samples 616
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1350*10)=-3.07681559705083
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SCUBE2 [Title/Abstract] AND DENND5A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DENND5A(9286508)-SCUBE2(9144441), # samples:2
DENND5A(9171628)-SCUBE2(9043502), # samples:2
SCUBE2(9087438)-DENND5A(9192324), # samples:1
Anticipated loss of major functional domain due to fusion event.SCUBE2-DENND5A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SCUBE2-DENND5A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SCUBE2-DENND5A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SCUBE2-DENND5A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DENND5A-SCUBE2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DENND5A-SCUBE2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SCUBE2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DENND5A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A27R-01ASCUBE2chr11

9087438

-DENND5Achr11

9192324

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000457346SCUBE2chr119087438-ENST00000328194DENND5Achr119192324-3729925512882943
ENST00000457346SCUBE2chr119087438-ENST00000530044DENND5Achr119192324-3061925512744897
ENST00000309263SCUBE2chr119087438-ENST00000328194DENND5Achr119192324-3727923492880943
ENST00000309263SCUBE2chr119087438-ENST00000530044DENND5Achr119192324-3059923492742897
ENST00000450649SCUBE2chr119087438-ENST00000328194DENND5Achr119192324-3672868182825935
ENST00000450649SCUBE2chr119087438-ENST00000530044DENND5Achr119192324-3004868182687889
ENST00000520467SCUBE2chr119087438-ENST00000328194DENND5Achr119192324-3725921472878943
ENST00000520467SCUBE2chr119087438-ENST00000530044DENND5Achr119192324-3057921472740897

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000457346ENST00000328194SCUBE2chr119087438-DENND5Achr119192324-0.0024215330.99757844
ENST00000457346ENST00000530044SCUBE2chr119087438-DENND5Achr119192324-0.0069302850.9930697
ENST00000309263ENST00000328194SCUBE2chr119087438-DENND5Achr119192324-0.0024281130.9975719
ENST00000309263ENST00000530044SCUBE2chr119087438-DENND5Achr119192324-0.0069432860.99305665
ENST00000450649ENST00000328194SCUBE2chr119087438-DENND5Achr119192324-0.0023385560.9976615
ENST00000450649ENST00000530044SCUBE2chr119087438-DENND5Achr119192324-0.0070542530.99294573
ENST00000520467ENST00000328194SCUBE2chr119087438-DENND5Achr119192324-0.0024540140.997546
ENST00000520467ENST00000530044SCUBE2chr119087438-DENND5Achr119192324-0.006985040.99301493

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>79753_79753_1_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000309263_DENND5A_chr11_9192324_ENST00000328194_length(amino acids)=943AA_BP=291
MPATAEPSMGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR
QCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE
EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEV
TESNTTSVVDGDKRVKRRLLMEKAIELRLAKIDHTAIHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQ
HTEHLRLDNDQREKYIQEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIA
SLCDLLERIWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSLSTSGILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKA
RAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTAN
PWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGE
LLTSQPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHG
FKSPRLFKNVFIWDFLEKAQTYYETLEKNEVVPEENWHTRARNFCRFVTAINNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPIT

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>79753_79753_2_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000309263_DENND5A_chr11_9192324_ENST00000530044_length(amino acids)=897AA_BP=291
MPATAEPSMGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR
QCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE
EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEV
TESNTTSVVDGDKRVKRRLLMEKAIELRLAKIDHTAIHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQ
HTEHLRLDNDQREKYIQEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIA
SLCDLLERIWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSLSTSGILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKA
RAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTAN
PWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGE
LLTSQPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHG

--------------------------------------------------------------

>79753_79753_3_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000450649_DENND5A_chr11_9192324_ENST00000328194_length(amino acids)=935AA_BP=283
MGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDEC
GNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNK
DHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSV
VDGDKRVKRRLLMEKAIELRLAKIDHTAIHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLD
NDQREKYIQEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIASLCDLLER
IWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSLSTSGILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSM
EKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGE
LGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGELLTSQPEV
DERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHGFKSPRLFK
NVFIWDFLEKAQTYYETLEKNEVVPEENWHTRARNFCRFVTAINNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVA

--------------------------------------------------------------

>79753_79753_4_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000450649_DENND5A_chr11_9192324_ENST00000530044_length(amino acids)=889AA_BP=283
MGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDEC
GNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNK
DHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSV
VDGDKRVKRRLLMEKAIELRLAKIDHTAIHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLD
NDQREKYIQEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIASLCDLLER
IWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSLSTSGILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSM
EKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGE
LGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGELLTSQPEV
DERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHGFKSPRLFK

--------------------------------------------------------------

>79753_79753_5_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000457346_DENND5A_chr11_9192324_ENST00000328194_length(amino acids)=943AA_BP=291
MPATAEPSMGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR
QCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE
EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEV
TESNTTSVVDGDKRVKRRLLMEKAIELRLAKIDHTAIHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQ
HTEHLRLDNDQREKYIQEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIA
SLCDLLERIWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSLSTSGILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKA
RAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTAN
PWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGE
LLTSQPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHG
FKSPRLFKNVFIWDFLEKAQTYYETLEKNEVVPEENWHTRARNFCRFVTAINNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPIT

--------------------------------------------------------------

>79753_79753_6_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000457346_DENND5A_chr11_9192324_ENST00000530044_length(amino acids)=897AA_BP=291
MPATAEPSMGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR
QCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE
EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEV
TESNTTSVVDGDKRVKRRLLMEKAIELRLAKIDHTAIHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQ
HTEHLRLDNDQREKYIQEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIA
SLCDLLERIWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSLSTSGILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKA
RAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTAN
PWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGE
LLTSQPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHG

--------------------------------------------------------------

>79753_79753_7_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000520467_DENND5A_chr11_9192324_ENST00000328194_length(amino acids)=943AA_BP=291
MPATAEPSMGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR
QCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE
EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEV
TESNTTSVVDGDKRVKRRLLMEKAIELRLAKIDHTAIHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQ
HTEHLRLDNDQREKYIQEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIA
SLCDLLERIWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSLSTSGILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKA
RAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTAN
PWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGE
LLTSQPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHG
FKSPRLFKNVFIWDFLEKAQTYYETLEKNEVVPEENWHTRARNFCRFVTAINNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPIT

--------------------------------------------------------------

>79753_79753_8_SCUBE2-DENND5A_SCUBE2_chr11_9087438_ENST00000520467_DENND5A_chr11_9192324_ENST00000530044_length(amino acids)=897AA_BP=291
MPATAEPSMGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR
QCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE
EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEV
TESNTTSVVDGDKRVKRRLLMEKAIELRLAKIDHTAIHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQ
HTEHLRLDNDQREKYIQEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIA
SLCDLLERIWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSLSTSGILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKA
RAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTAN
PWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGE
LLTSQPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHG

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:9286508/chr11:9144441)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DENND5A

Q6IQ26

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:G3V7Q0, ECO:0000269|PubMed:20937701}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000309263-722128_168283.33333333333331000.0DomainEGF-like 3%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000309263-722177_213283.33333333333331000.0DomainEGF-like 4
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000309263-722217_252283.33333333333331000.0DomainEGF-like 5
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000309263-72245_85283.33333333333331000.0DomainEGF-like 1%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000309263-72286_127283.33333333333331000.0DomainEGF-like 2%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000450649-718128_168283.3333333333333808.0DomainEGF-like 3%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000450649-718177_213283.3333333333333808.0DomainEGF-like 4
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000450649-718217_252283.3333333333333808.0DomainEGF-like 5
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000450649-71845_85283.3333333333333808.0DomainEGF-like 1%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000450649-71886_127283.3333333333333808.0DomainEGF-like 2%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000520467-722128_168283.3333333333333972.0DomainEGF-like 3%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000520467-722177_213283.3333333333333972.0DomainEGF-like 4
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000520467-722217_252283.3333333333333972.0DomainEGF-like 5
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000520467-72245_85283.3333333333333972.0DomainEGF-like 1%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000520467-72286_127283.3333333333333972.0DomainEGF-like 2%3B calcium-binding
TgeneDENND5Achr11:9087438chr11:9192324ENST000003281947231134_1282635.33333333333341288.0DomainRUN 2
TgeneDENND5Achr11:9087438chr11:9192324ENST00000328194723787_950635.33333333333341288.0DomainRUN 1
TgeneDENND5Achr11:9087438chr11:9192324ENST00000328194723954_1062635.33333333333341288.0DomainPLAT
TgeneDENND5Achr11:9087438chr11:9192324ENST000005300447231134_1282635.33333333333341242.0DomainRUN 2
TgeneDENND5Achr11:9087438chr11:9192324ENST00000530044723787_950635.33333333333341242.0DomainRUN 1
TgeneDENND5Achr11:9087438chr11:9192324ENST00000530044723954_1062635.33333333333341242.0DomainPLAT

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000309263-722286_321283.33333333333331000.0DomainEGF-like 6
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000309263-722323_363283.33333333333331000.0DomainEGF-like 7%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000309263-722364_402283.33333333333331000.0DomainEGF-like 8%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000309263-722403_443283.33333333333331000.0DomainEGF-like 9%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000309263-722809_921283.33333333333331000.0DomainCUB
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000450649-718286_321283.3333333333333808.0DomainEGF-like 6
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000450649-718323_363283.3333333333333808.0DomainEGF-like 7%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000450649-718364_402283.3333333333333808.0DomainEGF-like 8%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000450649-718403_443283.3333333333333808.0DomainEGF-like 9%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000450649-718809_921283.3333333333333808.0DomainCUB
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000520467-722286_321283.3333333333333972.0DomainEGF-like 6
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000520467-722323_363283.3333333333333972.0DomainEGF-like 7%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000520467-722364_402283.3333333333333972.0DomainEGF-like 8%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000520467-722403_443283.3333333333333972.0DomainEGF-like 9%3B calcium-binding
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000520467-722809_921283.3333333333333972.0DomainCUB
TgeneDENND5Achr11:9087438chr11:9192324ENST000003281947233_9635.33333333333341288.0Compositional biasNote=Poly-Gly
TgeneDENND5Achr11:9087438chr11:9192324ENST00000328194723593_598635.33333333333341288.0Compositional biasNote=Poly-Asp
TgeneDENND5Achr11:9087438chr11:9192324ENST000005300447233_9635.33333333333341242.0Compositional biasNote=Poly-Gly
TgeneDENND5Achr11:9087438chr11:9192324ENST00000530044723593_598635.33333333333341242.0Compositional biasNote=Poly-Asp
TgeneDENND5Achr11:9087438chr11:9192324ENST00000328194723278_414635.33333333333341288.0DomaincDENN
TgeneDENND5Achr11:9087438chr11:9192324ENST00000328194723416_598635.33333333333341288.0DomaindDENN
TgeneDENND5Achr11:9087438chr11:9192324ENST0000032819472357_259635.33333333333341288.0DomainuDENN
TgeneDENND5Achr11:9087438chr11:9192324ENST00000530044723278_414635.33333333333341242.0DomaincDENN
TgeneDENND5Achr11:9087438chr11:9192324ENST00000530044723416_598635.33333333333341242.0DomaindDENN
TgeneDENND5Achr11:9087438chr11:9192324ENST0000053004472357_259635.33333333333341242.0DomainuDENN


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SCUBE2
DENND5A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000309263-722847_856283.33333333333331000.0the cholesterol-anchor of SHH
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000450649-718847_856283.3333333333333808.0the cholesterol-anchor of SHH
HgeneSCUBE2chr11:9087438chr11:9192324ENST00000520467-722847_856283.3333333333333972.0the cholesterol-anchor of SHH


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Related Drugs to SCUBE2-DENND5A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SCUBE2-DENND5A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource