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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:SCUBE2-LDHC

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SCUBE2-LDHC
	FusionPDB ID: 79754
	FusionGDB2.0 ID: 79754
		Hgene	Tgene
	Gene symbol	SCUBE2	LDHC
	Gene ID	57758	3948
	Gene name	signal peptide, CUB domain and EGF like domain containing 2	lactate dehydrogenase C
	Synonyms	CEGB1\|CEGF1\|CEGP1\|scube/You	CT32\|LDH3\|LDHX
	Cytomap	11p15.4	11p15.1
	Type of gene	protein-coding	protein-coding
	Description	signal peptide, CUB and EGF-like domain-containing protein 2	L-lactate dehydrogenase C chainLDH testis subunitLDH-CLDH-Xcancer/testis antigen 32lactate dehydrogenase C4lactate dehydrogenase c variant 1lactate dehydrogenase c variant 3lactate dehydrogenase c variant 4lactate dehydrogenase c variant 5testis
	Modification date	20200313	20200313
	UniProtAcc	.	P07864
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000309263, ENST00000450649, ENST00000457346, ENST00000520467, ENST00000534295,	ENST00000535809, ENST00000536880, ENST00000537486, ENST00000546146, ENST00000280704, ENST00000541669, ENST00000544105,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 6 X 4=144	3 X 3 X 2=18
	# samples	6	3
	** MAII score	log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: SCUBE2 [Title/Abstract] AND LDHC [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SCUBE2(9090917)-LDHC(18451284), # samples:3
Anticipated loss of major functional domain due to fusion event.	SCUBE2-LDHC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SCUBE2-LDHC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SCUBE2-LDHC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SCUBE2-LDHC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across SCUBE2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LDHC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-FD-A5BV-01A	SCUBE2	chr11	9090917	-	LDHC	chr11	18451284	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000457346	SCUBE2	chr11	9090917	-	ENST00000541669	LDHC	chr11	18451284	+	2404	718	51	1472	473
ENST00000457346	SCUBE2	chr11	9090917	-	ENST00000280704	LDHC	chr11	18451284	+	1589	718	51	1472	473
ENST00000457346	SCUBE2	chr11	9090917	-	ENST00000544105	LDHC	chr11	18451284	+	1349	718	51	1199	382
ENST00000309263	SCUBE2	chr11	9090917	-	ENST00000541669	LDHC	chr11	18451284	+	2402	716	49	1470	473
ENST00000309263	SCUBE2	chr11	9090917	-	ENST00000280704	LDHC	chr11	18451284	+	1587	716	49	1470	473
ENST00000309263	SCUBE2	chr11	9090917	-	ENST00000544105	LDHC	chr11	18451284	+	1347	716	49	1197	382
ENST00000450649	SCUBE2	chr11	9090917	-	ENST00000541669	LDHC	chr11	18451284	+	2347	661	18	1415	465
ENST00000450649	SCUBE2	chr11	9090917	-	ENST00000280704	LDHC	chr11	18451284	+	1532	661	18	1415	465
ENST00000450649	SCUBE2	chr11	9090917	-	ENST00000544105	LDHC	chr11	18451284	+	1292	661	18	1142	374
ENST00000520467	SCUBE2	chr11	9090917	-	ENST00000541669	LDHC	chr11	18451284	+	2400	714	47	1468	473
ENST00000520467	SCUBE2	chr11	9090917	-	ENST00000280704	LDHC	chr11	18451284	+	1585	714	47	1468	473
ENST00000520467	SCUBE2	chr11	9090917	-	ENST00000544105	LDHC	chr11	18451284	+	1345	714	47	1195	382

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000457346	ENST00000541669	SCUBE2	chr11	9090917	-	LDHC	chr11	18451284	+	0.00068082	0.9993192
ENST00000457346	ENST00000280704	SCUBE2	chr11	9090917	-	LDHC	chr11	18451284	+	0.001742461	0.9982576
ENST00000457346	ENST00000544105	SCUBE2	chr11	9090917	-	LDHC	chr11	18451284	+	0.00445161	0.99554837
ENST00000309263	ENST00000541669	SCUBE2	chr11	9090917	-	LDHC	chr11	18451284	+	0.000686757	0.99931324
ENST00000309263	ENST00000280704	SCUBE2	chr11	9090917	-	LDHC	chr11	18451284	+	0.001787877	0.9982121
ENST00000309263	ENST00000544105	SCUBE2	chr11	9090917	-	LDHC	chr11	18451284	+	0.004560825	0.99543923
ENST00000450649	ENST00000541669	SCUBE2	chr11	9090917	-	LDHC	chr11	18451284	+	0.000571186	0.9994288
ENST00000450649	ENST00000280704	SCUBE2	chr11	9090917	-	LDHC	chr11	18451284	+	0.001580436	0.9984195
ENST00000450649	ENST00000544105	SCUBE2	chr11	9090917	-	LDHC	chr11	18451284	+	0.00465828	0.9953418
ENST00000520467	ENST00000541669	SCUBE2	chr11	9090917	-	LDHC	chr11	18451284	+	0.00070048	0.9992995
ENST00000520467	ENST00000280704	SCUBE2	chr11	9090917	-	LDHC	chr11	18451284	+	0.001877905	0.99812204
ENST00000520467	ENST00000544105	SCUBE2	chr11	9090917	-	LDHC	chr11	18451284	+	0.004609428	0.99539053

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>79754_79754_1_SCUBE2-LDHC_SCUBE2_chr11_9090917_ENST00000309263_LDHC_chr11_18451284_ENST00000280704_length(amino acids)=473AA_BP=223
MPATAEPSMGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR
QCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE
EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCIYYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSIIPAIVHYSP
DCKILVVSNPVDILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGVHPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKLG
TDSDKEHWKNIHKQVIQSAYEIIKLKGYTSWAIGLSVMDLVGSILKNLRRVHPVSTMVKGLYGIKEELFLSIPCVLGRNGVSDVVKINLN

--------------------------------------------------------------

>79754_79754_2_SCUBE2-LDHC_SCUBE2_chr11_9090917_ENST00000309263_LDHC_chr11_18451284_ENST00000541669_length(amino acids)=473AA_BP=223
MPATAEPSMGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR
QCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE
EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCIYYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSIIPAIVHYSP
DCKILVVSNPVDILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGVHPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKLG
TDSDKEHWKNIHKQVIQSAYEIIKLKGYTSWAIGLSVMDLVGSILKNLRRVHPVSTMVKGLYGIKEELFLSIPCVLGRNGVSDVVKINLN

--------------------------------------------------------------

>79754_79754_3_SCUBE2-LDHC_SCUBE2_chr11_9090917_ENST00000309263_LDHC_chr11_18451284_ENST00000544105_length(amino acids)=382AA_BP=223
MPATAEPSMGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR
QCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE
EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCIYYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSIIPAIVHYSP
DCKILVVSNPVDILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGVHPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKLG

--------------------------------------------------------------

>79754_79754_4_SCUBE2-LDHC_SCUBE2_chr11_9090917_ENST00000450649_LDHC_chr11_18451284_ENST00000280704_length(amino acids)=465AA_BP=215
MGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDEC
GNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNK
DHGCSHICKEAPRGSVACECRPGFELAKNQRDCIYYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSIIPAIVHYSPDCKILVVS
NPVDILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGVHPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKLGTDSDKEHW
KNIHKQVIQSAYEIIKLKGYTSWAIGLSVMDLVGSILKNLRRVHPVSTMVKGLYGIKEELFLSIPCVLGRNGVSDVVKINLNSEEEALFK

--------------------------------------------------------------

>79754_79754_5_SCUBE2-LDHC_SCUBE2_chr11_9090917_ENST00000450649_LDHC_chr11_18451284_ENST00000541669_length(amino acids)=465AA_BP=215
MGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDEC
GNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNK
DHGCSHICKEAPRGSVACECRPGFELAKNQRDCIYYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSIIPAIVHYSPDCKILVVS
NPVDILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGVHPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKLGTDSDKEHW
KNIHKQVIQSAYEIIKLKGYTSWAIGLSVMDLVGSILKNLRRVHPVSTMVKGLYGIKEELFLSIPCVLGRNGVSDVVKINLNSEEEALFK

--------------------------------------------------------------

>79754_79754_6_SCUBE2-LDHC_SCUBE2_chr11_9090917_ENST00000450649_LDHC_chr11_18451284_ENST00000544105_length(amino acids)=374AA_BP=215
MGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDEC
GNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNK
DHGCSHICKEAPRGSVACECRPGFELAKNQRDCIYYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSIIPAIVHYSPDCKILVVS
NPVDILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGVHPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKLGTDSDKEHW

--------------------------------------------------------------

>79754_79754_7_SCUBE2-LDHC_SCUBE2_chr11_9090917_ENST00000457346_LDHC_chr11_18451284_ENST00000280704_length(amino acids)=473AA_BP=223
MPATAEPSMGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR
QCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE
EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCIYYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSIIPAIVHYSP
DCKILVVSNPVDILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGVHPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKLG
TDSDKEHWKNIHKQVIQSAYEIIKLKGYTSWAIGLSVMDLVGSILKNLRRVHPVSTMVKGLYGIKEELFLSIPCVLGRNGVSDVVKINLN

--------------------------------------------------------------

>79754_79754_8_SCUBE2-LDHC_SCUBE2_chr11_9090917_ENST00000457346_LDHC_chr11_18451284_ENST00000541669_length(amino acids)=473AA_BP=223
MPATAEPSMGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR
QCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE
EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCIYYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSIIPAIVHYSP
DCKILVVSNPVDILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGVHPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKLG
TDSDKEHWKNIHKQVIQSAYEIIKLKGYTSWAIGLSVMDLVGSILKNLRRVHPVSTMVKGLYGIKEELFLSIPCVLGRNGVSDVVKINLN

--------------------------------------------------------------

>79754_79754_9_SCUBE2-LDHC_SCUBE2_chr11_9090917_ENST00000457346_LDHC_chr11_18451284_ENST00000544105_length(amino acids)=382AA_BP=223
MPATAEPSMGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR
QCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE
EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCIYYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSIIPAIVHYSP
DCKILVVSNPVDILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGVHPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKLG

--------------------------------------------------------------

>79754_79754_10_SCUBE2-LDHC_SCUBE2_chr11_9090917_ENST00000520467_LDHC_chr11_18451284_ENST00000280704_length(amino acids)=473AA_BP=223
MPATAEPSMGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR
QCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE
EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCIYYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSIIPAIVHYSP
DCKILVVSNPVDILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGVHPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKLG
TDSDKEHWKNIHKQVIQSAYEIIKLKGYTSWAIGLSVMDLVGSILKNLRRVHPVSTMVKGLYGIKEELFLSIPCVLGRNGVSDVVKINLN

--------------------------------------------------------------

>79754_79754_11_SCUBE2-LDHC_SCUBE2_chr11_9090917_ENST00000520467_LDHC_chr11_18451284_ENST00000541669_length(amino acids)=473AA_BP=223
MPATAEPSMGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR
QCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE
EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCIYYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSIIPAIVHYSP
DCKILVVSNPVDILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGVHPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKLG
TDSDKEHWKNIHKQVIQSAYEIIKLKGYTSWAIGLSVMDLVGSILKNLRRVHPVSTMVKGLYGIKEELFLSIPCVLGRNGVSDVVKINLN

--------------------------------------------------------------

>79754_79754_12_SCUBE2-LDHC_SCUBE2_chr11_9090917_ENST00000520467_LDHC_chr11_18451284_ENST00000544105_length(amino acids)=382AA_BP=223
MPATAEPSMGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGR
QCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSE
EGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCIYYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSIIPAIVHYSP
DCKILVVSNPVDILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGVHPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKLG

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:9090917/chr11:18451284)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	LDHC P07864
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Possible role in sperm motility.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000309263

128_168

214.33333333333334

1000.0

Domain

EGF-like 3%3B calcium-binding

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000309263

177_213

214.33333333333334

1000.0

Domain

EGF-like 4

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000309263

45_85

214.33333333333334

1000.0

Domain

EGF-like 1%3B calcium-binding

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000309263

86_127

214.33333333333334

1000.0

Domain

EGF-like 2%3B calcium-binding

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000450649

128_168

214.33333333333334

808.0

Domain

EGF-like 3%3B calcium-binding

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000450649

177_213

214.33333333333334

808.0

Domain

EGF-like 4

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000450649

45_85

214.33333333333334

808.0

Domain

EGF-like 1%3B calcium-binding

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000450649

86_127

214.33333333333334

808.0

Domain

EGF-like 2%3B calcium-binding

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000520467

128_168

214.33333333333334

972.0

Domain

EGF-like 3%3B calcium-binding

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000520467

177_213

214.33333333333334

972.0

Domain

EGF-like 4

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000520467

45_85

214.33333333333334

972.0

Domain

EGF-like 1%3B calcium-binding

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000520467

86_127

214.33333333333334

972.0

Domain

EGF-like 2%3B calcium-binding

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000309263

217_252

214.33333333333334

1000.0

Domain

EGF-like 5

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000309263

286_321

214.33333333333334

1000.0

Domain

EGF-like 6

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000309263

323_363

214.33333333333334

1000.0

Domain

EGF-like 7%3B calcium-binding

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000309263

364_402

214.33333333333334

1000.0

Domain

EGF-like 8%3B calcium-binding

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000309263

403_443

214.33333333333334

1000.0

Domain

EGF-like 9%3B calcium-binding

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000309263

809_921

214.33333333333334

1000.0

Domain

CUB

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000450649

217_252

214.33333333333334

808.0

Domain

EGF-like 5

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000450649

286_321

214.33333333333334

808.0

Domain

EGF-like 6

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000450649

323_363

214.33333333333334

808.0

Domain

EGF-like 7%3B calcium-binding

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000450649

364_402

214.33333333333334

808.0

Domain

EGF-like 8%3B calcium-binding

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000450649

403_443

214.33333333333334

808.0

Domain

EGF-like 9%3B calcium-binding

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000450649

809_921

214.33333333333334

808.0

Domain

CUB

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000520467

217_252

214.33333333333334

972.0

Domain

EGF-like 5

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000520467

286_321

214.33333333333334

972.0

Domain

EGF-like 6

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000520467

323_363

214.33333333333334

972.0

Domain

EGF-like 7%3B calcium-binding

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000520467

364_402

214.33333333333334

972.0

Domain

EGF-like 8%3B calcium-binding

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000520467

403_443

214.33333333333334

972.0

Domain

EGF-like 9%3B calcium-binding

Hgene

SCUBE2

chr11:9090917

chr11:18451284

ENST00000520467

809_921

214.33333333333334

972.0

Domain

CUB

Tgene

LDHC

chr11:9090917

chr11:18451284

ENST00000280704

29_57

81.33333333333333

333.0

Nucleotide binding

NAD

Tgene

LDHC

chr11:9090917

chr11:18451284

ENST00000541669

29_57

81.33333333333333

333.0

Nucleotide binding

NAD

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
SCUBE2
LDHC

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	SCUBE2	chr11:9090917	chr11:18451284	ENST00000309263	-	5	22	847_856	214.33333333333334	1000.0	the cholesterol-anchor of SHH
Hgene	SCUBE2	chr11:9090917	chr11:18451284	ENST00000450649	-	5	18	847_856	214.33333333333334	808.0	the cholesterol-anchor of SHH
Hgene	SCUBE2	chr11:9090917	chr11:18451284	ENST00000520467	-	5	22	847_856	214.33333333333334	972.0	the cholesterol-anchor of SHH

Top

Related Drugs to SCUBE2-LDHC

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to SCUBE2-LDHC

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source