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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SCYL1-FRMD8

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SCYL1-FRMD8
FusionPDB ID: 79769
FusionGDB2.0 ID: 79769
HgeneTgene
Gene symbol

SCYL1

FRMD8

Gene ID

57410

83786

Gene nameSCY1 like pseudokinase 1FERM domain containing 8
SynonymsGKLP|HT019|NKTL|NTKL|P105|SCAR21|TAPK|TEIF|TRAPFKSG44|iTAP
Cytomap

11q13.1

11q13.1

Type of geneprotein-codingprotein-coding
DescriptionN-terminal kinase-like proteinSCY1-like protein 1SCY1-like, kinase-like 1coated vesicle-associated kinase of 90 kDalikely ortholog of mouse N-terminal kinase-like proteintelomerase regulation-associated proteintelomerase transcriptional elements-intFERM domain-containing protein 8band4.1 inhibitor LRP interactorbiliiRhom Tail-Associated Protein
Modification date2020031320200313
UniProtAcc.

Q9BZ67

Ensembl transtripts involved in fusion geneENST idsENST00000270176, ENST00000279270, 
ENST00000420247, ENST00000524944, 
ENST00000525364, ENST00000527009, 
ENST00000533862, ENST00000534462, 
ENST00000355991, ENST00000416776, 
ENST00000531296, ENST00000317568, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 8 X 7=44810 X 11 X 10=1100
# samples 1418
** MAII scorelog2(14/448*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1100*10)=-2.61143471208235
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SCYL1 [Title/Abstract] AND FRMD8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SCYL1(65294588)-FRMD8(65172335), # samples:3
SCYL1(65300276)-FRMD8(65172335), # samples:3
Anticipated loss of major functional domain due to fusion event.SCYL1-FRMD8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SCYL1-FRMD8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SCYL1-FRMD8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SCYL1-FRMD8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SCYL1-FRMD8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SCYL1-FRMD8 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SCYL1-FRMD8 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
SCYL1-FRMD8 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSCYL1

GO:0006890

retrograde vesicle-mediated transport, Golgi to ER

18556652

TgeneFRMD8

GO:1904469

positive regulation of tumor necrosis factor secretion

29897333


check buttonFusion gene breakpoints across SCYL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FRMD8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0B7-01ASCYL1chr11

65294588

-FRMD8chr11

65172335

+
ChimerDB4BRCATCGA-BH-A0B7-01ASCYL1chr11

65294588

+FRMD8chr11

65172335

+
ChimerDB4BRCATCGA-BH-A0B7SCYL1chr11

65294588

+FRMD8chr11

65172334

+
ChimerDB4LUADTCGA-44-4112-01ASCYL1chr11

65300276

+FRMD8chr11

65172335

+
ChimerDB4LUADTCGA-55-8510-01ASCYL1chr11

65300276

+FRMD8chr11

65178713

+
ChimerDB4OVTCGA-24-1431-01ASCYL1chr11

65300276

+FRMD8chr11

65172335

+
ChimerDB4OVTCGA-24-1431SCYL1chr11

65300276

+FRMD8chr11

65172334

+
ChimerDB4UCECTCGA-BK-A139-02ASCYL1chr11

65300276

+FRMD8chr11

65156832

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000525364SCYL1chr1165294588+ENST00000317568FRMD8chr1165172335+3415926771249390
ENST00000270176SCYL1chr1165294588+ENST00000317568FRMD8chr1165172335+3415926771249390
ENST00000420247SCYL1chr1165294588+ENST00000317568FRMD8chr1165172335+3407918691241390
ENST00000533862SCYL1chr1165294588+ENST00000317568FRMD8chr1165172335+3380891421214390
ENST00000279270SCYL1chr1165294588+ENST00000317568FRMD8chr1165172335+3379890411213390
ENST00000524944SCYL1chr1165294588+ENST00000317568FRMD8chr1165172335+3371882331205390
ENST00000527009SCYL1chr1165294588+ENST00000317568FRMD8chr1165172335+33888992781222314
ENST00000525364SCYL1chr1165300276+ENST00000317568FRMD8chr1165172335+37961307771630517
ENST00000270176SCYL1chr1165300276+ENST00000317568FRMD8chr1165172335+37961307771630517
ENST00000420247SCYL1chr1165300276+ENST00000317568FRMD8chr1165172335+37881299691622517
ENST00000533862SCYL1chr1165300276+ENST00000317568FRMD8chr1165172335+37611272421595517
ENST00000279270SCYL1chr1165300276+ENST00000317568FRMD8chr1165172335+37601271411594517
ENST00000524944SCYL1chr1165300276+ENST00000317568FRMD8chr1165172335+37521263331586517
ENST00000527009SCYL1chr1165300276+ENST00000317568FRMD8chr1165172335+376912802781603441
ENST00000525364SCYL1chr1165294588+ENST00000317568FRMD8chr1165172334+3415926771249390
ENST00000270176SCYL1chr1165294588+ENST00000317568FRMD8chr1165172334+3415926771249390
ENST00000420247SCYL1chr1165294588+ENST00000317568FRMD8chr1165172334+3407918691241390
ENST00000533862SCYL1chr1165294588+ENST00000317568FRMD8chr1165172334+3380891421214390
ENST00000279270SCYL1chr1165294588+ENST00000317568FRMD8chr1165172334+3379890411213390
ENST00000524944SCYL1chr1165294588+ENST00000317568FRMD8chr1165172334+3371882331205390
ENST00000527009SCYL1chr1165294588+ENST00000317568FRMD8chr1165172334+33888992781222314
ENST00000525364SCYL1chr1165300276+ENST00000317568FRMD8chr1165172334+37961307771630517
ENST00000270176SCYL1chr1165300276+ENST00000317568FRMD8chr1165172334+37961307771630517
ENST00000420247SCYL1chr1165300276+ENST00000317568FRMD8chr1165172334+37881299691622517
ENST00000533862SCYL1chr1165300276+ENST00000317568FRMD8chr1165172334+37611272421595517
ENST00000279270SCYL1chr1165300276+ENST00000317568FRMD8chr1165172334+37601271411594517
ENST00000524944SCYL1chr1165300276+ENST00000317568FRMD8chr1165172334+37521263331586517
ENST00000527009SCYL1chr1165300276+ENST00000317568FRMD8chr1165172334+376912802781603441

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000525364ENST00000317568SCYL1chr1165294588+FRMD8chr1165172335+0.0060115680.9939884
ENST00000270176ENST00000317568SCYL1chr1165294588+FRMD8chr1165172335+0.0060115680.9939884
ENST00000420247ENST00000317568SCYL1chr1165294588+FRMD8chr1165172335+0.0059945480.9940055
ENST00000533862ENST00000317568SCYL1chr1165294588+FRMD8chr1165172335+0.0059431540.9940568
ENST00000279270ENST00000317568SCYL1chr1165294588+FRMD8chr1165172335+0.0059636430.9940363
ENST00000524944ENST00000317568SCYL1chr1165294588+FRMD8chr1165172335+0.0058703650.99412966
ENST00000527009ENST00000317568SCYL1chr1165294588+FRMD8chr1165172335+0.0547569650.945243
ENST00000525364ENST00000317568SCYL1chr1165300276+FRMD8chr1165172335+0.004280930.99571913
ENST00000270176ENST00000317568SCYL1chr1165300276+FRMD8chr1165172335+0.004280930.99571913
ENST00000420247ENST00000317568SCYL1chr1165300276+FRMD8chr1165172335+0.0042160730.99578387
ENST00000533862ENST00000317568SCYL1chr1165300276+FRMD8chr1165172335+0.0041188490.9958812
ENST00000279270ENST00000317568SCYL1chr1165300276+FRMD8chr1165172335+0.0041478190.99585223
ENST00000524944ENST00000317568SCYL1chr1165300276+FRMD8chr1165172335+0.0041188790.9958811
ENST00000527009ENST00000317568SCYL1chr1165300276+FRMD8chr1165172335+0.0076392410.9923608
ENST00000525364ENST00000317568SCYL1chr1165294588+FRMD8chr1165172334+0.0060115680.9939884
ENST00000270176ENST00000317568SCYL1chr1165294588+FRMD8chr1165172334+0.0060115680.9939884
ENST00000420247ENST00000317568SCYL1chr1165294588+FRMD8chr1165172334+0.0059945480.9940055
ENST00000533862ENST00000317568SCYL1chr1165294588+FRMD8chr1165172334+0.0059431540.9940568
ENST00000279270ENST00000317568SCYL1chr1165294588+FRMD8chr1165172334+0.0059636430.9940363
ENST00000524944ENST00000317568SCYL1chr1165294588+FRMD8chr1165172334+0.0058703650.99412966
ENST00000527009ENST00000317568SCYL1chr1165294588+FRMD8chr1165172334+0.0547569650.945243
ENST00000525364ENST00000317568SCYL1chr1165300276+FRMD8chr1165172334+0.004280930.99571913
ENST00000270176ENST00000317568SCYL1chr1165300276+FRMD8chr1165172334+0.004280930.99571913
ENST00000420247ENST00000317568SCYL1chr1165300276+FRMD8chr1165172334+0.0042160730.99578387
ENST00000533862ENST00000317568SCYL1chr1165300276+FRMD8chr1165172334+0.0041188490.9958812
ENST00000279270ENST00000317568SCYL1chr1165300276+FRMD8chr1165172334+0.0041478190.99585223
ENST00000524944ENST00000317568SCYL1chr1165300276+FRMD8chr1165172334+0.0041188790.9958811
ENST00000527009ENST00000317568SCYL1chr1165300276+FRMD8chr1165172334+0.0076392410.9923608

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>79769_79769_1_SCYL1-FRMD8_SCYL1_chr11_65294588_ENST00000270176_FRMD8_chr11_65172334_ENST00000317568_length(amino acids)=390AA_BP=282
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAPVQRPKLRRQGSVVSSRIQHLSTIDYVEDGKGIRRVKP

--------------------------------------------------------------

>79769_79769_2_SCYL1-FRMD8_SCYL1_chr11_65294588_ENST00000270176_FRMD8_chr11_65172335_ENST00000317568_length(amino acids)=390AA_BP=282
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAPVQRPKLRRQGSVVSSRIQHLSTIDYVEDGKGIRRVKP

--------------------------------------------------------------

>79769_79769_3_SCYL1-FRMD8_SCYL1_chr11_65294588_ENST00000279270_FRMD8_chr11_65172334_ENST00000317568_length(amino acids)=390AA_BP=282
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAPVQRPKLRRQGSVVSSRIQHLSTIDYVEDGKGIRRVKP

--------------------------------------------------------------

>79769_79769_4_SCYL1-FRMD8_SCYL1_chr11_65294588_ENST00000279270_FRMD8_chr11_65172335_ENST00000317568_length(amino acids)=390AA_BP=282
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAPVQRPKLRRQGSVVSSRIQHLSTIDYVEDGKGIRRVKP

--------------------------------------------------------------

>79769_79769_5_SCYL1-FRMD8_SCYL1_chr11_65294588_ENST00000420247_FRMD8_chr11_65172334_ENST00000317568_length(amino acids)=390AA_BP=282
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAPVQRPKLRRQGSVVSSRIQHLSTIDYVEDGKGIRRVKP

--------------------------------------------------------------

>79769_79769_6_SCYL1-FRMD8_SCYL1_chr11_65294588_ENST00000420247_FRMD8_chr11_65172335_ENST00000317568_length(amino acids)=390AA_BP=282
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAPVQRPKLRRQGSVVSSRIQHLSTIDYVEDGKGIRRVKP

--------------------------------------------------------------

>79769_79769_7_SCYL1-FRMD8_SCYL1_chr11_65294588_ENST00000524944_FRMD8_chr11_65172334_ENST00000317568_length(amino acids)=390AA_BP=282
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAPVQRPKLRRQGSVVSSRIQHLSTIDYVEDGKGIRRVKP

--------------------------------------------------------------

>79769_79769_8_SCYL1-FRMD8_SCYL1_chr11_65294588_ENST00000524944_FRMD8_chr11_65172335_ENST00000317568_length(amino acids)=390AA_BP=282
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAPVQRPKLRRQGSVVSSRIQHLSTIDYVEDGKGIRRVKP

--------------------------------------------------------------

>79769_79769_9_SCYL1-FRMD8_SCYL1_chr11_65294588_ENST00000525364_FRMD8_chr11_65172334_ENST00000317568_length(amino acids)=390AA_BP=282
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAPVQRPKLRRQGSVVSSRIQHLSTIDYVEDGKGIRRVKP

--------------------------------------------------------------

>79769_79769_10_SCYL1-FRMD8_SCYL1_chr11_65294588_ENST00000525364_FRMD8_chr11_65172335_ENST00000317568_length(amino acids)=390AA_BP=282
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAPVQRPKLRRQGSVVSSRIQHLSTIDYVEDGKGIRRVKP

--------------------------------------------------------------

>79769_79769_11_SCYL1-FRMD8_SCYL1_chr11_65294588_ENST00000527009_FRMD8_chr11_65172334_ENST00000317568_length(amino acids)=314AA_BP=206
MAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSA
QGNGGGPPRKGIPELEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPAR
FLQNCRAPGGFMSNRFVETNLFLEEIQAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAPVQRPKLRRQGSVVSSRIQHLSTI

--------------------------------------------------------------

>79769_79769_12_SCYL1-FRMD8_SCYL1_chr11_65294588_ENST00000527009_FRMD8_chr11_65172335_ENST00000317568_length(amino acids)=314AA_BP=206
MAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSA
QGNGGGPPRKGIPELEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPAR
FLQNCRAPGGFMSNRFVETNLFLEEIQAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAPVQRPKLRRQGSVVSSRIQHLSTI

--------------------------------------------------------------

>79769_79769_13_SCYL1-FRMD8_SCYL1_chr11_65294588_ENST00000533862_FRMD8_chr11_65172334_ENST00000317568_length(amino acids)=390AA_BP=282
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAPVQRPKLRRQGSVVSSRIQHLSTIDYVEDGKGIRRVKP

--------------------------------------------------------------

>79769_79769_14_SCYL1-FRMD8_SCYL1_chr11_65294588_ENST00000533862_FRMD8_chr11_65172335_ENST00000317568_length(amino acids)=390AA_BP=282
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAPVQRPKLRRQGSVVSSRIQHLSTIDYVEDGKGIRRVKP

--------------------------------------------------------------

>79769_79769_15_SCYL1-FRMD8_SCYL1_chr11_65300276_ENST00000270176_FRMD8_chr11_65172334_ENST00000317568_length(amino acids)=517AA_BP=410
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAP

--------------------------------------------------------------

>79769_79769_16_SCYL1-FRMD8_SCYL1_chr11_65300276_ENST00000270176_FRMD8_chr11_65172335_ENST00000317568_length(amino acids)=517AA_BP=410
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAP

--------------------------------------------------------------

>79769_79769_17_SCYL1-FRMD8_SCYL1_chr11_65300276_ENST00000279270_FRMD8_chr11_65172334_ENST00000317568_length(amino acids)=517AA_BP=410
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAP

--------------------------------------------------------------

>79769_79769_18_SCYL1-FRMD8_SCYL1_chr11_65300276_ENST00000279270_FRMD8_chr11_65172335_ENST00000317568_length(amino acids)=517AA_BP=410
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAP

--------------------------------------------------------------

>79769_79769_19_SCYL1-FRMD8_SCYL1_chr11_65300276_ENST00000420247_FRMD8_chr11_65172334_ENST00000317568_length(amino acids)=517AA_BP=410
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAP

--------------------------------------------------------------

>79769_79769_20_SCYL1-FRMD8_SCYL1_chr11_65300276_ENST00000420247_FRMD8_chr11_65172335_ENST00000317568_length(amino acids)=517AA_BP=410
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAP

--------------------------------------------------------------

>79769_79769_21_SCYL1-FRMD8_SCYL1_chr11_65300276_ENST00000524944_FRMD8_chr11_65172334_ENST00000317568_length(amino acids)=517AA_BP=410
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAP

--------------------------------------------------------------

>79769_79769_22_SCYL1-FRMD8_SCYL1_chr11_65300276_ENST00000524944_FRMD8_chr11_65172335_ENST00000317568_length(amino acids)=517AA_BP=410
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAP

--------------------------------------------------------------

>79769_79769_23_SCYL1-FRMD8_SCYL1_chr11_65300276_ENST00000525364_FRMD8_chr11_65172334_ENST00000317568_length(amino acids)=517AA_BP=410
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAP

--------------------------------------------------------------

>79769_79769_24_SCYL1-FRMD8_SCYL1_chr11_65300276_ENST00000525364_FRMD8_chr11_65172335_ENST00000317568_length(amino acids)=517AA_BP=410
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAP

--------------------------------------------------------------

>79769_79769_25_SCYL1-FRMD8_SCYL1_chr11_65300276_ENST00000527009_FRMD8_chr11_65172334_ENST00000317568_length(amino acids)=441AA_BP=334
MAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSA
QGNGGGPPRKGIPELEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPAR
FLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEY
QQKIIPVVVKMFSSTDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKAELMSSLIEYCIELSQAAEPAGPQDS

--------------------------------------------------------------

>79769_79769_26_SCYL1-FRMD8_SCYL1_chr11_65300276_ENST00000527009_FRMD8_chr11_65172335_ENST00000317568_length(amino acids)=441AA_BP=334
MAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSA
QGNGGGPPRKGIPELEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPAR
FLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEY
QQKIIPVVVKMFSSTDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKAELMSSLIEYCIELSQAAEPAGPQDS

--------------------------------------------------------------

>79769_79769_27_SCYL1-FRMD8_SCYL1_chr11_65300276_ENST00000533862_FRMD8_chr11_65172334_ENST00000317568_length(amino acids)=517AA_BP=410
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAP

--------------------------------------------------------------

>79769_79769_28_SCYL1-FRMD8_SCYL1_chr11_65300276_ENST00000533862_FRMD8_chr11_65172335_ENST00000317568_length(amino acids)=517AA_BP=410
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:65294588/chr11:65172335)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FRMD8

Q9BZ67

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019). {ECO:0000269|PubMed:19572019, ECO:0000269|PubMed:29897333, ECO:0000269|PubMed:29897336}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCYL1chr11:65300276chr11:65172334ENST00000270176+91814_314410.0809.0DomainProtein kinase
HgeneSCYL1chr11:65300276chr11:65172334ENST00000279270+91714_314410.0782.0DomainProtein kinase
HgeneSCYL1chr11:65300276chr11:65172334ENST00000420247+91814_314410.0792.0DomainProtein kinase
HgeneSCYL1chr11:65300276chr11:65172334ENST00000533862+91814_314410.0788.0DomainProtein kinase
HgeneSCYL1chr11:65300276chr11:65172335ENST00000270176+91814_314410.0809.0DomainProtein kinase
HgeneSCYL1chr11:65300276chr11:65172335ENST00000279270+91714_314410.0782.0DomainProtein kinase
HgeneSCYL1chr11:65300276chr11:65172335ENST00000420247+91814_314410.0792.0DomainProtein kinase
HgeneSCYL1chr11:65300276chr11:65172335ENST00000533862+91814_314410.0788.0DomainProtein kinase
HgeneSCYL1chr11:65300276chr11:65172334ENST00000270176+918350_388410.0809.0RepeatNote=HEAT 1
HgeneSCYL1chr11:65300276chr11:65172334ENST00000279270+917350_388410.0782.0RepeatNote=HEAT 1
HgeneSCYL1chr11:65300276chr11:65172334ENST00000420247+918350_388410.0792.0RepeatNote=HEAT 1
HgeneSCYL1chr11:65300276chr11:65172334ENST00000533862+918350_388410.0788.0RepeatNote=HEAT 1
HgeneSCYL1chr11:65300276chr11:65172335ENST00000270176+918350_388410.0809.0RepeatNote=HEAT 1
HgeneSCYL1chr11:65300276chr11:65172335ENST00000279270+917350_388410.0782.0RepeatNote=HEAT 1
HgeneSCYL1chr11:65300276chr11:65172335ENST00000420247+918350_388410.0792.0RepeatNote=HEAT 1
HgeneSCYL1chr11:65300276chr11:65172335ENST00000533862+918350_388410.0788.0RepeatNote=HEAT 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCYL1chr11:65294588chr11:65172334ENST00000270176+618761_797283.0809.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65294588chr11:65172334ENST00000279270+617761_797283.0782.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65294588chr11:65172334ENST00000420247+618761_797283.0792.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65294588chr11:65172334ENST00000533862+618761_797283.0788.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65294588chr11:65172335ENST00000270176+618761_797283.0809.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65294588chr11:65172335ENST00000279270+617761_797283.0782.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65294588chr11:65172335ENST00000420247+618761_797283.0792.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65294588chr11:65172335ENST00000533862+618761_797283.0788.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65300276chr11:65172334ENST00000270176+918761_797410.0809.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65300276chr11:65172334ENST00000279270+917761_797410.0782.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65300276chr11:65172334ENST00000420247+918761_797410.0792.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65300276chr11:65172334ENST00000533862+918761_797410.0788.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65300276chr11:65172335ENST00000270176+918761_797410.0809.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65300276chr11:65172335ENST00000279270+917761_797410.0782.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65300276chr11:65172335ENST00000420247+918761_797410.0792.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65300276chr11:65172335ENST00000533862+918761_797410.0788.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65294588chr11:65172334ENST00000270176+618589_619283.0809.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65294588chr11:65172334ENST00000279270+617589_619283.0782.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65294588chr11:65172334ENST00000420247+618589_619283.0792.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65294588chr11:65172334ENST00000533862+618589_619283.0788.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65294588chr11:65172335ENST00000270176+618589_619283.0809.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65294588chr11:65172335ENST00000279270+617589_619283.0782.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65294588chr11:65172335ENST00000420247+618589_619283.0792.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65294588chr11:65172335ENST00000533862+618589_619283.0788.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65300276chr11:65172334ENST00000270176+918589_619410.0809.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65300276chr11:65172334ENST00000279270+917589_619410.0782.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65300276chr11:65172334ENST00000420247+918589_619410.0792.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65300276chr11:65172334ENST00000533862+918589_619410.0788.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65300276chr11:65172335ENST00000270176+918589_619410.0809.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65300276chr11:65172335ENST00000279270+917589_619410.0782.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65300276chr11:65172335ENST00000420247+918589_619410.0792.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65300276chr11:65172335ENST00000533862+918589_619410.0788.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65294588chr11:65172334ENST00000270176+61814_314283.0809.0DomainProtein kinase
HgeneSCYL1chr11:65294588chr11:65172334ENST00000279270+61714_314283.0782.0DomainProtein kinase
HgeneSCYL1chr11:65294588chr11:65172334ENST00000420247+61814_314283.0792.0DomainProtein kinase
HgeneSCYL1chr11:65294588chr11:65172334ENST00000533862+61814_314283.0788.0DomainProtein kinase
HgeneSCYL1chr11:65294588chr11:65172335ENST00000270176+61814_314283.0809.0DomainProtein kinase
HgeneSCYL1chr11:65294588chr11:65172335ENST00000279270+61714_314283.0782.0DomainProtein kinase
HgeneSCYL1chr11:65294588chr11:65172335ENST00000420247+61814_314283.0792.0DomainProtein kinase
HgeneSCYL1chr11:65294588chr11:65172335ENST00000533862+61814_314283.0788.0DomainProtein kinase
HgeneSCYL1chr11:65294588chr11:65172334ENST00000270176+618350_388283.0809.0RepeatNote=HEAT 1
HgeneSCYL1chr11:65294588chr11:65172334ENST00000270176+618389_427283.0809.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65294588chr11:65172334ENST00000270176+618507_545283.0809.0RepeatNote=HEAT 3
HgeneSCYL1chr11:65294588chr11:65172334ENST00000279270+617350_388283.0782.0RepeatNote=HEAT 1
HgeneSCYL1chr11:65294588chr11:65172334ENST00000279270+617389_427283.0782.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65294588chr11:65172334ENST00000279270+617507_545283.0782.0RepeatNote=HEAT 3
HgeneSCYL1chr11:65294588chr11:65172334ENST00000420247+618350_388283.0792.0RepeatNote=HEAT 1
HgeneSCYL1chr11:65294588chr11:65172334ENST00000420247+618389_427283.0792.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65294588chr11:65172334ENST00000420247+618507_545283.0792.0RepeatNote=HEAT 3
HgeneSCYL1chr11:65294588chr11:65172334ENST00000533862+618350_388283.0788.0RepeatNote=HEAT 1
HgeneSCYL1chr11:65294588chr11:65172334ENST00000533862+618389_427283.0788.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65294588chr11:65172334ENST00000533862+618507_545283.0788.0RepeatNote=HEAT 3
HgeneSCYL1chr11:65294588chr11:65172335ENST00000270176+618350_388283.0809.0RepeatNote=HEAT 1
HgeneSCYL1chr11:65294588chr11:65172335ENST00000270176+618389_427283.0809.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65294588chr11:65172335ENST00000270176+618507_545283.0809.0RepeatNote=HEAT 3
HgeneSCYL1chr11:65294588chr11:65172335ENST00000279270+617350_388283.0782.0RepeatNote=HEAT 1
HgeneSCYL1chr11:65294588chr11:65172335ENST00000279270+617389_427283.0782.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65294588chr11:65172335ENST00000279270+617507_545283.0782.0RepeatNote=HEAT 3
HgeneSCYL1chr11:65294588chr11:65172335ENST00000420247+618350_388283.0792.0RepeatNote=HEAT 1
HgeneSCYL1chr11:65294588chr11:65172335ENST00000420247+618389_427283.0792.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65294588chr11:65172335ENST00000420247+618507_545283.0792.0RepeatNote=HEAT 3
HgeneSCYL1chr11:65294588chr11:65172335ENST00000533862+618350_388283.0788.0RepeatNote=HEAT 1
HgeneSCYL1chr11:65294588chr11:65172335ENST00000533862+618389_427283.0788.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65294588chr11:65172335ENST00000533862+618507_545283.0788.0RepeatNote=HEAT 3
HgeneSCYL1chr11:65300276chr11:65172334ENST00000270176+918389_427410.0809.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65300276chr11:65172334ENST00000270176+918507_545410.0809.0RepeatNote=HEAT 3
HgeneSCYL1chr11:65300276chr11:65172334ENST00000279270+917389_427410.0782.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65300276chr11:65172334ENST00000279270+917507_545410.0782.0RepeatNote=HEAT 3
HgeneSCYL1chr11:65300276chr11:65172334ENST00000420247+918389_427410.0792.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65300276chr11:65172334ENST00000420247+918507_545410.0792.0RepeatNote=HEAT 3
HgeneSCYL1chr11:65300276chr11:65172334ENST00000533862+918389_427410.0788.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65300276chr11:65172334ENST00000533862+918507_545410.0788.0RepeatNote=HEAT 3
HgeneSCYL1chr11:65300276chr11:65172335ENST00000270176+918389_427410.0809.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65300276chr11:65172335ENST00000270176+918507_545410.0809.0RepeatNote=HEAT 3
HgeneSCYL1chr11:65300276chr11:65172335ENST00000279270+917389_427410.0782.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65300276chr11:65172335ENST00000279270+917507_545410.0782.0RepeatNote=HEAT 3
HgeneSCYL1chr11:65300276chr11:65172335ENST00000420247+918389_427410.0792.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65300276chr11:65172335ENST00000420247+918507_545410.0792.0RepeatNote=HEAT 3
HgeneSCYL1chr11:65300276chr11:65172335ENST00000533862+918389_427410.0788.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65300276chr11:65172335ENST00000533862+918507_545410.0788.0RepeatNote=HEAT 3
TgeneFRMD8chr11:65294588chr11:65172334ENST0000031756881130_376357.0465.0DomainFERM
TgeneFRMD8chr11:65294588chr11:65172334ENST0000035599171030_376301.0409.0DomainFERM
TgeneFRMD8chr11:65294588chr11:65172335ENST0000031756881130_376357.0465.0DomainFERM
TgeneFRMD8chr11:65294588chr11:65172335ENST0000035599171030_376301.0409.0DomainFERM
TgeneFRMD8chr11:65300276chr11:65172334ENST0000031756881130_376357.0465.0DomainFERM
TgeneFRMD8chr11:65300276chr11:65172334ENST0000035599171030_376301.0409.0DomainFERM
TgeneFRMD8chr11:65300276chr11:65172335ENST0000031756881130_376357.0465.0DomainFERM
TgeneFRMD8chr11:65300276chr11:65172335ENST0000035599171030_376301.0409.0DomainFERM


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1100_SCYL1_65300276_FRMD8_65172335_1100_SCYL1_65300276_FRMD8_65172335_ranked_0.pdbSCYL16530027665300276ENST00000317568FRMD8chr1165172335+
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAP
517


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SCYL1_pLDDT.png
all structure
all structure
FRMD8_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SCYL1
FRMD8


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSCYL1chr11:65294588chr11:65172334ENST00000270176+618793_808283.0809.0COPB1
HgeneSCYL1chr11:65294588chr11:65172334ENST00000279270+617793_808283.0782.0COPB1
HgeneSCYL1chr11:65294588chr11:65172334ENST00000420247+618793_808283.0792.0COPB1
HgeneSCYL1chr11:65294588chr11:65172334ENST00000533862+618793_808283.0788.0COPB1
HgeneSCYL1chr11:65294588chr11:65172335ENST00000270176+618793_808283.0809.0COPB1
HgeneSCYL1chr11:65294588chr11:65172335ENST00000279270+617793_808283.0782.0COPB1
HgeneSCYL1chr11:65294588chr11:65172335ENST00000420247+618793_808283.0792.0COPB1
HgeneSCYL1chr11:65294588chr11:65172335ENST00000533862+618793_808283.0788.0COPB1
HgeneSCYL1chr11:65300276chr11:65172334ENST00000270176+918793_808410.0809.0COPB1
HgeneSCYL1chr11:65300276chr11:65172334ENST00000279270+917793_808410.0782.0COPB1
HgeneSCYL1chr11:65300276chr11:65172334ENST00000420247+918793_808410.0792.0COPB1
HgeneSCYL1chr11:65300276chr11:65172334ENST00000533862+918793_808410.0788.0COPB1
HgeneSCYL1chr11:65300276chr11:65172335ENST00000270176+918793_808410.0809.0COPB1
HgeneSCYL1chr11:65300276chr11:65172335ENST00000279270+917793_808410.0782.0COPB1
HgeneSCYL1chr11:65300276chr11:65172335ENST00000420247+918793_808410.0792.0COPB1
HgeneSCYL1chr11:65300276chr11:65172335ENST00000533862+918793_808410.0788.0COPB1


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Related Drugs to SCYL1-FRMD8


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SCYL1-FRMD8


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource