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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SCYL1-TRPM8

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SCYL1-TRPM8
FusionPDB ID: 79775
FusionGDB2.0 ID: 79775
HgeneTgene
Gene symbol

SCYL1

TRPM8

Gene ID

57410

79054

Gene nameSCY1 like pseudokinase 1transient receptor potential cation channel subfamily M member 8
SynonymsGKLP|HT019|NKTL|NTKL|P105|SCAR21|TAPK|TEIF|TRAPLTRPC6|LTrpC-6|TRPP8|trp-p8
Cytomap

11q13.1

2q37.1

Type of geneprotein-codingprotein-coding
DescriptionN-terminal kinase-like proteinSCY1-like protein 1SCY1-like, kinase-like 1coated vesicle-associated kinase of 90 kDalikely ortholog of mouse N-terminal kinase-like proteintelomerase regulation-associated proteintelomerase transcriptional elements-inttransient receptor potential cation channel subfamily M member 8TRPM8 cationic channeltransient receptor potential p8transient receptor potential subfamily M member 8
Modification date2020031320200313
UniProtAcc.

TCAF1

Ensembl transtripts involved in fusion geneENST idsENST00000270176, ENST00000279270, 
ENST00000420247, ENST00000524944, 
ENST00000525364, ENST00000533862, 
ENST00000534462, ENST00000527009, 
ENST00000355722, ENST00000409625, 
ENST00000466594, ENST00000324695, 
ENST00000433712, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 8 X 7=4487 X 7 X 4=196
# samples 147
** MAII scorelog2(14/448*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SCYL1 [Title/Abstract] AND TRPM8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SCYL1(65306175)-TRPM8(234826043), # samples:1
Anticipated loss of major functional domain due to fusion event.SCYL1-TRPM8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SCYL1-TRPM8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SCYL1-TRPM8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SCYL1-TRPM8 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SCYL1-TRPM8 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
SCYL1-TRPM8 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
SCYL1-TRPM8 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSCYL1

GO:0006890

retrograde vesicle-mediated transport, Golgi to ER

18556652


check buttonFusion gene breakpoints across SCYL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TRPM8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-7327-01ASCYL1chr11

65306175

-TRPM8chr2

234826043

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000525364SCYL1chr1165306175-ENST00000324695TRPM8chr2234826043+82052584262459381104
ENST00000533862SCYL1chr1165306175-ENST00000324695TRPM8chr2234826043+81912570261059241104
ENST00000279270SCYL1chr1165306175-ENST00000324695TRPM8chr2234826043+81692548258859021104

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000525364ENST00000324695SCYL1chr1165306175-TRPM8chr2234826043+0.0094354070.9905646
ENST00000533862ENST00000324695SCYL1chr1165306175-TRPM8chr2234826043+0.0092323280.99076766
ENST00000279270ENST00000324695SCYL1chr1165306175-TRPM8chr2234826043+0.0091593090.9908407

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>79775_79775_1_SCYL1-TRPM8_SCYL1_chr11_65306175_ENST00000279270_TRPM8_chr2_234826043_ENST00000324695_length(amino acids)=1104AA_BP=
MSFRAARLSMRNRRNDTLDSTRTLYSSASRSTDLSYSESDLVNFIQANFKKRECVFFTKDSKATENVCKCGYAQSQHMEGTQINQSEKWN
YKKHTKEFPTDAFGDIQFETLGKKGKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL
TGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGYFLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCHGH
PTVEAKLRNQLEKYISERTIQDSNYGGKIPIVCFAQGGGKETLKAINTSIKNKIPCVVVEGSGQIADVIASLVEVEDALTSSAVKEKLVR
FLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIFTND
RRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRGFRKEDR
NGRDEMDIELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFT
ECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKKPVDKH
KKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQWYVNGVNYFTDLWNVMDTLGLFYFI
AGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIF
RSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENN
DQVWKFQRYFLVQEYCSRLNIPFPFIVFAYFYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRH

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>79775_79775_2_SCYL1-TRPM8_SCYL1_chr11_65306175_ENST00000525364_TRPM8_chr2_234826043_ENST00000324695_length(amino acids)=1104AA_BP=
MSFRAARLSMRNRRNDTLDSTRTLYSSASRSTDLSYSESDLVNFIQANFKKRECVFFTKDSKATENVCKCGYAQSQHMEGTQINQSEKWN
YKKHTKEFPTDAFGDIQFETLGKKGKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL
TGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGYFLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCHGH
PTVEAKLRNQLEKYISERTIQDSNYGGKIPIVCFAQGGGKETLKAINTSIKNKIPCVVVEGSGQIADVIASLVEVEDALTSSAVKEKLVR
FLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIFTND
RRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRGFRKEDR
NGRDEMDIELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFT
ECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKKPVDKH
KKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQWYVNGVNYFTDLWNVMDTLGLFYFI
AGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIF
RSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENN
DQVWKFQRYFLVQEYCSRLNIPFPFIVFAYFYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRH

--------------------------------------------------------------

>79775_79775_3_SCYL1-TRPM8_SCYL1_chr11_65306175_ENST00000533862_TRPM8_chr2_234826043_ENST00000324695_length(amino acids)=1104AA_BP=
MSFRAARLSMRNRRNDTLDSTRTLYSSASRSTDLSYSESDLVNFIQANFKKRECVFFTKDSKATENVCKCGYAQSQHMEGTQINQSEKWN
YKKHTKEFPTDAFGDIQFETLGKKGKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL
TGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGYFLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCHGH
PTVEAKLRNQLEKYISERTIQDSNYGGKIPIVCFAQGGGKETLKAINTSIKNKIPCVVVEGSGQIADVIASLVEVEDALTSSAVKEKLVR
FLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIFTND
RRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRGFRKEDR
NGRDEMDIELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFT
ECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKKPVDKH
KKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQWYVNGVNYFTDLWNVMDTLGLFYFI
AGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIF
RSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENN
DQVWKFQRYFLVQEYCSRLNIPFPFIVFAYFYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRH

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:65306175/chr2:234826043)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TRPM8

TCAF1

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.921

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCYL1chr11:65306175chr2:234826043ENST00000270176-1818761_797855.0809.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65306175chr2:234826043ENST00000279270-1717761_797835.6666666666666782.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65306175chr2:234826043ENST00000420247-1818761_797838.0792.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65306175chr2:234826043ENST00000533862-1818761_797842.6666666666666788.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65306175chr2:234826043ENST00000270176-1818589_619855.0809.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65306175chr2:234826043ENST00000279270-1717589_619835.6666666666666782.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65306175chr2:234826043ENST00000420247-1818589_619838.0792.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65306175chr2:234826043ENST00000533862-1818589_619842.6666666666666788.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65306175chr2:234826043ENST00000270176-181814_314855.0809.0DomainProtein kinase
HgeneSCYL1chr11:65306175chr2:234826043ENST00000279270-171714_314835.6666666666666782.0DomainProtein kinase
HgeneSCYL1chr11:65306175chr2:234826043ENST00000420247-181814_314838.0792.0DomainProtein kinase
HgeneSCYL1chr11:65306175chr2:234826043ENST00000533862-181814_314842.6666666666666788.0DomainProtein kinase
HgeneSCYL1chr11:65306175chr2:234826043ENST00000270176-1818350_388855.0809.0RepeatNote=HEAT 1
HgeneSCYL1chr11:65306175chr2:234826043ENST00000270176-1818389_427855.0809.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65306175chr2:234826043ENST00000270176-1818507_545855.0809.0RepeatNote=HEAT 3
HgeneSCYL1chr11:65306175chr2:234826043ENST00000279270-1717350_388835.6666666666666782.0RepeatNote=HEAT 1
HgeneSCYL1chr11:65306175chr2:234826043ENST00000279270-1717389_427835.6666666666666782.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65306175chr2:234826043ENST00000279270-1717507_545835.6666666666666782.0RepeatNote=HEAT 3
HgeneSCYL1chr11:65306175chr2:234826043ENST00000420247-1818350_388838.0792.0RepeatNote=HEAT 1
HgeneSCYL1chr11:65306175chr2:234826043ENST00000420247-1818389_427838.0792.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65306175chr2:234826043ENST00000420247-1818507_545838.0792.0RepeatNote=HEAT 3
HgeneSCYL1chr11:65306175chr2:234826043ENST00000533862-1818350_388842.6666666666666788.0RepeatNote=HEAT 1
HgeneSCYL1chr11:65306175chr2:234826043ENST00000533862-1818389_427842.6666666666666788.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65306175chr2:234826043ENST00000533862-1818507_545842.6666666666666788.0RepeatNote=HEAT 3
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-1261071_110401834.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneTRPM8chr11:65306175chr2:234826043ENST00000355722051071_11040193.0Coiled coilOntology_term=ECO:0000255
TgeneTRPM8chr11:65306175chr2:234826043ENST00000409625051071_11040166.0Coiled coilOntology_term=ECO:0000255
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126187_19501834.6666666666667RegionNote=Epitope%3B activates specific cytotoxic T lymphocytes
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205187_1950193.0RegionNote=Epitope%3B activates specific cytotoxic T lymphocytes
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505187_1950166.0RegionNote=Epitope%3B activates specific cytotoxic T lymphocytes
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-1261_69101834.6666666666667Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126713_73401834.6666666666667Topological domainExtracellular
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126756_75901834.6666666666667Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126781_79401834.6666666666667Topological domainExtracellular
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126816_82901834.6666666666667Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126851_95801834.6666666666667Topological domainExtracellular
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126980_110401834.6666666666667Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST00000355722051_6910193.0Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205713_7340193.0Topological domainExtracellular
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205756_7590193.0Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205781_7940193.0Topological domainExtracellular
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205816_8290193.0Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205851_9580193.0Topological domainExtracellular
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205980_11040193.0Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST00000409625051_6910166.0Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505713_7340166.0Topological domainExtracellular
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505756_7590166.0Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505781_7940166.0Topological domainExtracellular
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505816_8290166.0Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505851_9580166.0Topological domainExtracellular
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505980_11040166.0Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126692_71201834.6666666666667TransmembraneHelical%3B Name%3D1
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126735_75501834.6666666666667TransmembraneHelical%3B Name%3D2
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126760_78001834.6666666666667TransmembraneHelical%3B Name%3D3
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126795_81501834.6666666666667TransmembraneHelical%3B Name%3D4
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126830_85001834.6666666666667TransmembraneHelical%3B Name%3D5
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126959_97901834.6666666666667TransmembraneHelical%3B Name%3D6
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205692_7120193.0TransmembraneHelical%3B Name%3D1
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205735_7550193.0TransmembraneHelical%3B Name%3D2
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205760_7800193.0TransmembraneHelical%3B Name%3D3
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205795_8150193.0TransmembraneHelical%3B Name%3D4
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205830_8500193.0TransmembraneHelical%3B Name%3D5
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205959_9790193.0TransmembraneHelical%3B Name%3D6
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505692_7120166.0TransmembraneHelical%3B Name%3D1
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505735_7550166.0TransmembraneHelical%3B Name%3D2
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505760_7800166.0TransmembraneHelical%3B Name%3D3
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505795_8150166.0TransmembraneHelical%3B Name%3D4
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505830_8500166.0TransmembraneHelical%3B Name%3D5
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505959_9790166.0TransmembraneHelical%3B Name%3D6

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SCYL1
TRPM8


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SCYL1-TRPM8


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SCYL1-TRPM8


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource